|
Name |
Accession |
Description |
Interval |
E-value |
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-452 |
0e+00 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 882.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 1 MISVTLSQLAEILRGELKGADLTLDAVTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRPLDTDLPQLIV 80
Cdd:PRK10773 1 MISVTLSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 81 KDTRLAFGELAAWVRAQVPARVVALTGSSGKTSVKEMTASILSQCGNTLYTAGNLNNDIGVPMTLLRLNNDYDYAVIELG 160
Cdd:PRK10773 81 KDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 161 ANHQGEIAWTVGLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGDRKVWRFS 240
Cdd:PRK10773 161 ANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 241 PNAANS-DFSADNVHVTSHGTEFSLQTPTGSIDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVPGRLFP 319
Cdd:PRK10773 241 PNAANSvDFTATNIHVTSHGTEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 320 VQLAENQLLLDDSYNANVGSMTAAVQVLSEMPGYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSTGKLSQAISH 399
Cdd:PRK10773 321 IQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAISE 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 835227988 400 ASGVGEHFADKTALTAHLKALIAEHQIMTILVKGSRSAAMEEVVRALQENGTC 452
Cdd:PRK10773 401 ASGVGEHFADKTALIARLKALLAEHQVITILVKGSRSAAMEEVVRALQENGTC 453
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-451 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 572.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 2 ISVTLSQLAEILRGELKGA-DLTLDAVTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRPLDTDLPQLIV 80
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGDpDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 81 KDTRLAFGELAAWVRAQVPARVVALTGSSGKTSVKEMTASILSQCGNTLYTAGNLNNDIGVPMTLLRLNNDYDYAVIELG 160
Cdd:COG0770 81 DDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 161 ANHQGEIAWTVGLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGDRkVWRFS 240
Cdd:COG0770 161 MNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKAR-VLTFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 241 PNaANSDFSADNVHVTSHGTEFSLQTPTGSIDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVPGRLFPV 320
Cdd:COG0770 240 LS-EDADVRAEDIELDEDGTRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 321 QLAENQLLLDDSYNANVGSMTAAVQVLSEMP--GYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSTGKLSQAIS 398
Cdd:COG0770 319 EGAGGVTLIDDSYNANPDSMKAALDVLAQLPggGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAIA 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 835227988 399 HASGV--GEHFADKTALTAHLKALIAEHQimTILVKGSRSAAMEEVVRALQENGT 451
Cdd:COG0770 399 EAAGGerAEHFEDKEELLAALKALLRPGD--VVLVKGSRGMGLERVVEALKEGAA 451
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
29-446 |
2.25e-159 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 456.73 E-value: 2.25e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 29 TDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRPLDTD--LPQLIVKDTRLAFGELAAWVRAQVPARVVALT 106
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDngLPQILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 107 GSSGKTSVKEMTASILSQCGNTLYTAGNLNNDIGVPMTLLRLNNDYDYAVIELGANHQGEIAWTVGLTRPEAALVNNLAA 186
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 187 AHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGDRKVWRFSPNaaNSDFSADNVHVTSHG-TEFSLQ 265
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFE--GGDFVAKDISYSALGsTSFTLV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 266 TPTGSIDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVPGRLFpVQLAENQLLLDDSYNANVGSMTAAVQ 345
Cdd:TIGR01143 239 APGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTYNANPDSMRAALD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 346 VLSEMPGYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSTGKLSQAISHASGV-GEHFADKTALTAHLKALIAEH 424
Cdd:TIGR01143 318 ALARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGKqGKHFADKDELLAFLKTLVRKG 397
|
410 420
....*....|....*....|..
gi 835227988 425 QimTILVKGSRSAAMEEVVRAL 446
Cdd:TIGR01143 398 D--VVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
19-447 |
7.80e-133 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 406.40 E-value: 7.80e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 19 GADLTLDAVTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRPL-DTDLPQLIVKDTRLAFGELAAWVRAQ 97
Cdd:PRK11929 521 NSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVaDVDLPQIVVDDTRAALGRLATAWRAR 600
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 98 VPARVVALTGSSGKTSVKEMTASILSQ---CGNTLYTAGNLNNDIGVPMTLLRLNNDYDYAVIELGANHQGEIAWTVGLT 174
Cdd:PRK11929 601 FSLPVVAITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIA 680
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 175 RPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGDRKVWRF----SPNAANSDFSA 250
Cdd:PRK11929 681 APTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFglqpGADVYAEKIAK 760
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 251 DNVHVTSHGTEFSLQTPTGSIDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVPGRLFPVQLAENQLLLD 330
Cdd:PRK11929 761 DISVGEAGGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIID 840
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 331 DSYNANVGSMTAAVQVLSEMP-GYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLSTGKLSQAISHASGVG--EHF 407
Cdd:PRK11929 841 DTYNANPDSMRAAIDVLAELPnGPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAARDAAAAFGAGarGVC 920
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 835227988 408 ADKTALTAHLKALIAEHQImtILVKGSRSAAMEEVVRALQ 447
Cdd:PRK11929 921 ASVDEIIAALRGALPEGDS--VLIKGSRFMRLERVVDALS 958
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
5-449 |
1.86e-71 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 233.51 E-value: 1.86e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 5 TLSQLAEILRGELKGA---DLTldAVTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRP----LDTDLPQ 77
Cdd:PRK14093 8 TSDAMAEAMGATRSGAlprDVT--GISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAqrdkFAADAPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 78 LIVKDTRLAFGELAAWVRAQVPARVVALTGSSGKTSVKEMTASILSQCGNTLYTAGNLNNDIGVPMTLLRLNNDYDYAVI 157
Cdd:PRK14093 86 LVVDDVLAALRDLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 158 ELGANHQGEIAWTVGLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGDRKVW 237
Cdd:PRK14093 166 EIGMNHAGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAGIA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 238 RFSPNAANSDFSADNVHVTSHGTEFSLQTPTGSIDVL--LPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVPG 315
Cdd:PRK14093 246 RIVSFGADEKADARLLDVALHADCSAVHADILGHDVTykLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 316 RLFPVQLAENQ---LLLDDSYNANVGSMTAAVQVLSEMP----GYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVL 388
Cdd:PRK14093 326 RGVRHTLEVGGgeaTLIDESYNANPASMAAALGVLGRAPvgpqGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVF 405
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 835227988 389 STGKLSQAISHA--SGV-GEHFADKTALTAHLKALIAEHQimTILVKGSRSAAMEEVVRALQEN 449
Cdd:PRK14093 406 CCGPLMRNLWDAlsSGKrGGYAEDAAALESQVVAAIRAGD--VIMVKGSLGSRMKTIVTALEKR 467
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
27-358 |
3.86e-51 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 179.12 E-value: 3.86e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 27 VTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRP---LDTDLPQLIVKDTRLAFGELAAWV--RAQVPAR 101
Cdd:COG0769 2 ITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPgalLAAGVPVIVVPDPRAALALLAAAFygHPSQKLK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 102 VVALTGSSGKTSVKEMTASILSQCGntlYTAGN---LNNDIGV-----------PMTLLRL-----NNDYDYAVIE---- 158
Cdd:COG0769 82 LIGVTGTNGKTTTTYLLAQILRALG---KKTGLigtVGNGIGGelipsslttpeALDLQRLlaemvDAGVTHVVMEvssh 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 159 -LganHQG---EIAWTVG----LTRPeaalvnnlaaaHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSI 230
Cdd:COG0769 159 aL---DQGrvdGVRFDVAvftnLTRD-----------HLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 231 IGDRkVWRFSPNAaNSDFSADNVHVTSHGTEFSLQTPTGSIDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDL 310
Cdd:COG0769 225 APAR-VITYGLKA-DADLRATDIELSADGTRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKL 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 835227988 311 QAVPGRLFPVQLAENQLLLDDsYNANVGSMTAAVQVLSEMPGYRVLVV 358
Cdd:COG0769 303 KGVPGRMERVDGGQGPTVIVD-YAHTPDALENVLEALRPHTKGRLIVV 349
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
2-448 |
1.54e-47 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 174.76 E-value: 1.54e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 2 ISVTLSQLAEILRGELKG-ADLTLDAVTTDTRKVT--PGCLFVALKGERFDAHDFADKAQESGAGALLVSRPLD--TDLP 76
Cdd:PRK11930 1 MSYTLESISGILGAEGLGdKDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVSEEKHpeESYP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 77 Q---LIVKDTRLAFGELAAWVRAQVPARVVALTGSSGKTSVKEMTASILSQCGNTLYTAGNLNNDIGVPMTLLRLNNDYD 153
Cdd:PRK11930 81 DanfLKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 154 YAVIELGANHQGEIAWTVGLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFTglsANGIAIMNADNNDWLN-WQSIIG 232
Cdd:PRK11930 161 LGIFEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFK---DCDVIIYNGDNELISScITKSNL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 233 DRKVWRFSPNAANSDFSADNVHVTSHGTEFSLQTPTGSIDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQA 312
Cdd:PRK11930 238 TLKLISWSRKDPEAPLYIPFVEKKEDHTVISYTYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 313 VPGRLFPVQLAENQLLLDDSYNANVGSMTAAVQVLS--EMPGYRVLVVGDMAELGAESEACHVQVGEAAKAAGIDRVLST 390
Cdd:PRK11930 318 VAMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNrrSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIGI 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 391 GK--LSQAISHASGVGEHFADKTALTAHLKALIAEHQimTILVKGSRSAAMEEVVRALQE 448
Cdd:PRK11930 398 GEeiSSEASKFEGTEKEFFKTTEAFLKSFAFLKFRNE--LILVKGARKFEFEQITELLEQ 455
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
106-283 |
7.14e-44 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 152.46 E-value: 7.14e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 106 TGSSGKTSVKEMTASILSQCGNTLYTAG--------NLNNDIGVPMTLLRL-NNDYDYAVIELGANHQGEiAWTVGLTRP 176
Cdd:pfam08245 2 TGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMvEAGAEYAVLEVSSHGLGE-GRLSGLLKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 177 EAALVNNLAAAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGDR--KVWRFSPNaANSDFSADNVH 254
Cdd:pfam08245 81 DIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAgvRVITYGIE-GEADLRAANIE 159
|
170 180 190
....*....|....*....|....*....|
gi 835227988 255 VTSHGTEFSL-QTPTGSIDVLLPLPGRHNI 283
Cdd:pfam08245 160 LSSDGTSFDLfTVPGGELEIEIPLLGRHNV 189
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
20-317 |
4.89e-34 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 132.56 E-value: 4.89e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 20 ADLTLDAVTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRPLD--TDLPQLIVKDTRLAFGELAAWV--R 95
Cdd:PRK00139 11 APVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEagTGVPVIIVPDLRKALALLAAAFygH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 96 AQVPARVVALTGSSGKTSVKEMTASILSQCGNTlyTA--GNLNNDIG-----------VPMTLLRL-----NNDYDYAVI 157
Cdd:PRK00139 91 PSDKLKLIGVTGTNGKTTTAYLLAQILRLLGEK--TAliGTLGNGIGgelipsglttpDALDLQRLlaelvDAGVTYAAM 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 158 E-----LganHQGEIA---WTVG----LTRpeaalvnnlaaAHLEGFGSLAGVAKAKGEIFTGLSanGIAIMNADnndwl 225
Cdd:PRK00139 169 EvsshaL---DQGRVDglkFDVAvftnLSR-----------DHLDYHGTMEDYLAAKARLFSELG--LAAVINAD----- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 226 nwqSIIGDR---KVWRFSPNAANSDFSADNVHVTSHGTEFSLQTptgsiDVLLPLPGRHNIANALAAAALSMAVGATPEA 302
Cdd:PRK00139 228 ---DEVGRRllaLPDAYAVSMAGADLRATDVEYTDSGQTFTLVT-----EVESPLIGRFNVSNLLAALAALLALGVPLED 299
|
330
....*....|....*
gi 835227988 303 IKAGLKDLQAVPGRL 317
Cdd:PRK00139 300 ALAALAKLQGVPGRM 314
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
21-358 |
5.20e-34 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 132.83 E-value: 5.20e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 21 DLTLDAVTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRPLDTDL---PQLIVKDTRLAFGELAAWVrAQ 97
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFYVapvPVIIVPDLRHALSSLAAAF-YG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 98 VPAR---VVALTGSSGKTSVKEMTASILSQCG------NTLYTAGNLNNDIGVPMTL-----------LRLNNDY--DYA 155
Cdd:TIGR01085 80 HPSKklkVIGVTGTNGKTTTTSLIAQLLRLLGkktgliGTIGYRLGGNDLIKNPAALttpealtlqstLAEMVEAgaQYA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 156 VIELgANH---QGEIA---WTVG----LTRpeaalvnnlaaAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNAD---NN 222
Cdd:TIGR01085 160 VMEV-SSHalaQGRVRgvrFDAAvftnLSR-----------DHLDFHGTMENYFAAKASLFTELGLKRFAVINLDdeyGA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 223 DWLN------WQSIIGDRKVWRfspnaaNSDFSADNVHVTSHGTEFSLQTPTGSIDVLLPLPGRHNIanalAAAALSMAV 296
Cdd:TIGR01085 228 QFVKrlpkdiTVSAITQPADGR------AQDIKITDSGYSFEGQQFTFETPAGEGHLHTPLIGRFNV----YNLLAALAT 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 835227988 297 -----GATPEAIKAGLKDLQAVPGRLFPVQLAENQLLLDDsYNANVGSMTAAVQVLSEMPGYRVLVV 358
Cdd:TIGR01085 298 llhlgGIDLEDIVAALEKFRGVPGRMELVDGGQKFLVIVD-YAHTPDALEKALRTLRKHKDGRLIVV 363
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
16-331 |
1.54e-27 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 115.96 E-value: 1.54e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 16 ELKGADLTLDAVTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRP-----LDTDLPQLIVKDTRLAFGEL 90
Cdd:PRK11929 21 WLRGCVAATADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEgedqvAAADALVLPVADLRKALGEL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 91 AA--WVRAQVPARVVALTGSSGKTSVKEMTASILSQCGNTLYTAGNLNNDIGV-----------PMTLLRLNNDY----- 152
Cdd:PRK11929 101 AArwYGRPSEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDGrlipgslttpdAIILHRILARMraaga 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 153 DYAVIElgANHQGEIAWTVGLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSII- 231
Cdd:PRK11929 181 DAVAME--ASSHGLEQGRLDGLRIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLLAALp 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 232 -GDRKVWrfSPNAANSDFSADNVHVTSHGTEFSLQTPTGSIDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDL 310
Cdd:PRK11929 259 rGLKVGY--SPQNAGADVQARDLRATAHGQVFTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAV 336
|
330 340
....*....|....*....|....
gi 835227988 311 QAVPGRL---FPVQLAENQLLLDD 331
Cdd:PRK11929 337 SPVPGRMervGPTAGAQGPLVVVD 360
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
89-320 |
7.32e-18 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 85.52 E-value: 7.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 89 ELAAWVraqVPARVVALTGSSGKTSVKEMTASILSQCGNTLYTAGNlnndIGVPM-TLLRLNNDYDYAVIELGAnHQgeI 167
Cdd:COG0771 97 ELAYRL---SPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGN----IGTPLlDLLLEPEPPDVYVLELSS-FQ--L 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 168 AWTVGLT---------RPEaalvnnlaaaHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGDRKVWr 238
Cdd:COG0771 167 ETTPSLRpdvavilniTPD----------HLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVP- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 239 FSPN-AANSDFSADNVHVTSHGTEfslqTPTGSIDvLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVPGRL 317
Cdd:COG0771 236 FSLKePLEGGAGLEDGKLVDRASG----EELLPVD-DLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRL 310
|
...
gi 835227988 318 FPV 320
Cdd:COG0771 311 EFV 313
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
89-359 |
3.82e-17 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 83.16 E-value: 3.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 89 ELAAWVraqVPARVVALTGSSGKTSVKEMTASILSQCGNTLYTAGNlnndIGVPMTLLRLNNDYDYAVIELgANHQgeIA 168
Cdd:TIGR01087 94 ELFLRL---VPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLEL-SSFQ--LE 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 169 WTVGLtRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGDRKVWRFSPNAANSDF 248
Cdd:TIGR01087 164 TTESL-RPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVEKDAERGL 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 249 SADNVHVTSHGTefslqtptgsiDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVPGRLFPVQLAENQLL 328
Cdd:TIGR01087 243 CIRDGGLYLKPN-----------DLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHF 311
|
250 260 270
....*....|....*....|....*....|.
gi 835227988 329 LDDSYNANVGsmtAAVQVLSEMPGYRVLVVG 359
Cdd:TIGR01087 312 YNDSKATNVH---ATLAALSAFDNPVILIVG 339
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
4-134 |
2.92e-12 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 68.14 E-value: 2.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 4 VTLSQLAEILR-----GELKGAD--------LTLDAVTTDTRKVTPGCLFVAlKGERFdAHDFADKAQESGAGALLVSRP 70
Cdd:PRK14022 1 ITIETLLDILKkdhnfREIIDQDhyhynysgVQFDDISYDSRTADEGTLFFA-KGAYF-KHKFLQNAITQGLKLYVSEKD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 835227988 71 LDTDLPQLIVKDTRLAFGELAAWV--RAQVPARVVALTGSSGKTSVKEMTASILSQCG-NTLYTAGN 134
Cdd:PRK14022 79 YEVGIPQVIVPDIKKAMSLIAMEFydNPQHKLKLLAFTGTKGKTTAAYFAYHILKQLHkPAMLSTMN 145
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
313-392 |
4.32e-12 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 61.98 E-value: 4.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 313 VPGRLFPVQLAENQLLLDDsYNANVGSMTAAVQVLSEM-PGYRVLVVGDMAELGAEseaCHVQVGEAAKAAGiDRVLSTG 391
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLfPGRLILVFGGMGDRDAE---FHALLGRLAAALA-DVVILTG 75
|
.
gi 835227988 392 K 392
Cdd:pfam02875 76 D 76
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
27-92 |
3.41e-11 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 59.17 E-value: 3.41e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 835227988 27 VTTDTRKVTPGCLFVALKGERFDAHDFADKAQESGAGALLVSRPLDT-----------DLPQLIVKDTRLAFGELAA 92
Cdd:pfam01225 5 VGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNispdnpeleaaKVPGIPVIDRREALAELAA 81
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
89-405 |
3.43e-11 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 64.99 E-value: 3.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 89 ELAAWVraqVPARVVALTGSSGKTSVKEMTASILSQCGNTLYTAGNlnndIGVPM--TLLRLNNDyDYAVIELgANHQGE 166
Cdd:PRK14106 100 ELAYRF---SKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPLidAVEEYGED-DIIVAEV-SSFQLE 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 167 iawTVGLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNdwlNWQSIIG--DRKVWRFSPNA- 243
Cdd:PRK14106 171 ---TIKEFKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDP---RTRSLAKkaKARVIFFSRKSl 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 244 -ANSDFSADNVHVTShgtefSLQTPTGSIDV-LLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVPGRLFPVQ 321
Cdd:PRK14106 245 lEEGVFVKNGKIVIS-----LGGKEEEVIDIdEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVA 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 322 LAENQLLLDDSYNANVgsmTAAVQVLSEMPGYRVLVVG---------DMAELGAESEACHVQVGE-------AAKAAGID 385
Cdd:PRK14106 320 EINGVKFINDSKGTNP---DAAIKALEAYETPIVLIAGgydkgsdfdEFAKAFKEKVKKLILLGEtaqeiaeAARKYGFD 396
|
330 340
....*....|....*....|
gi 835227988 386 RVLSTGKLSQAISHASGVGE 405
Cdd:PRK14106 397 NILFAETLEEAVKKAYEIAK 416
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
101-309 |
6.52e-09 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 57.77 E-value: 6.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 101 RVVALTGSSGKTSVKEMTASILSQCG-NTLYTAGNLNNDIGVPMtllRLNNDyDYAVIE----LGA--NHQGEIAwtVgL 173
Cdd:COG0773 105 RSIAVAGTHGKTTTTSMLAHILEEAGlDPTFLIGGILNNFGTNA---RLGDG-DYFVAEadesDGSflHYSPDIA--V-V 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 174 T--RPEaalvnnlaaaHLEGFGSLAGVAKAKGEIFTGLSANGIAIMNADNNdwlNWQSIIG--DRKVWRFSPNAaNSDFS 249
Cdd:COG0773 178 TniEAD----------HLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDP---GLRELLPrcGRPVITYGFSE-DADYR 243
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 835227988 250 ADNVHVTSHGTEFSLQTPTGSI-DVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKD 309
Cdd:COG0773 244 AENIRIDGGGSTFDVLRRGEELgEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALAS 304
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
101-333 |
2.13e-06 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 50.00 E-value: 2.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 101 RVVALTGSSGKTSVKEMTASILSQCG-NTLYTAGNLNNDIGvpmTLLRLNNDyDYAVIELG------ANHQGEIAwTVGL 173
Cdd:TIGR01082 100 HSIAVAGTHGKTTTTAMIAVILKEAGlDPTVVVGGLVKEAG---TNARLGSG-EYLVAEADesdasfLHLQPNVA-IVTN 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 174 TRPEaalvnnlaaaHLEGFG-SLAGVAKAKGEIFTGLSANGIAIMNADNNDWLNWQSIIGdRKVWRFSPNAANSDFSADN 252
Cdd:TIGR01082 175 IEPD----------HLDTYGsSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKAT-EQVITYGGSGEDADYRAEN 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 253 VHVTSHGTEFSLQTP-TGSIDVLLPLPGRHNIANALAAAALSMAVGATPEAIKAGLKDLQAVpGRLFPVQLAENQLLLDD 331
Cdd:TIGR01082 244 IQQSGAEGKFSVRGKgKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGV-KRRFEILGEFGGVLLID 322
|
..
gi 835227988 332 SY 333
Cdd:TIGR01082 323 DY 324
|
|
| LpxD |
COG1044 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope ... |
3-93 |
2.39e-06 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase is part of the Pathway/BioSystem: Lipid A biosynthesis
Pssm-ID: 440666 [Multi-domain] Cd Length: 335 Bit Score: 49.25 E-value: 2.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 3 SVTLSQLAEILRGELKG-ADLTLDAVTTdTRKVTPGCL-FVAlkGERfdahdFADKAQESGAGALLVSRPLDTDLPQ--- 77
Cdd:COG1044 1 SFTLAELAELLGGELVGdGDLEITGVAP-LEEAGPGDLsFLA--NPK-----YAKQLATTKASAVIVPPDFAAALPGlal 72
|
90
....*....|....*.
gi 835227988 78 LIVKDTRLAFGELAAW 93
Cdd:COG1044 73 IVVDNPYLAFAKLLQL 88
|
|
| lpxD |
PRK00892 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional |
3-93 |
3.26e-03 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional
Pssm-ID: 234858 [Multi-domain] Cd Length: 343 Bit Score: 39.35 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835227988 3 SVTLSQLAEILRGELKG-ADLTLDAVTT-DtrKVTPGCL-FVAlkGERfdahdFADKAQESGAGALLVSRPLDTDLPQ-- 77
Cdd:PRK00892 2 SLTLAELAELLGAELVGdGDIEITGVASlE--EAGPGQIsFLA--NPK-----YRKQLATTKAGAVIVSPDDAEFVPAgn 72
|
90
....*....|....*...
gi 835227988 78 --LIVKDTRLAFGELAAW 93
Cdd:PRK00892 73 alLVVKNPYLAFARLAQL 90
|
|
| LpxD |
pfam04613 |
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; UDP-3-O-[3-hydroxymyristoyl] ... |
53-93 |
6.59e-03 |
|
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase (EC 2.3.1.-) catalyzes an early step in lipid A biosynthesis: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl- [acyl carrier protein] -> UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl carrier protein]. Members of this family also contain a hexapeptide repeat (pfam00132). This family constitutes the non-repeating region of LPXD proteins.
Pssm-ID: 461366 [Multi-domain] Cd Length: 69 Bit Score: 35.17 E-value: 6.59e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 835227988 53 FADKAQESGAGALLVSRPLDTDLPQ----LIVKDTRLAFGELAAW 93
Cdd:pfam04613 25 YAKYLATTKASAVIVPPDFAPQAPAtatlLVVDNPYLAFAKLLQL 69
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