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Conserved domains on  [gi|835683625|ref|WP_047614087|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Rhizobium]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
10-98 4.34e-14

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 62.60  E-value: 4.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835683625  10 EDIRPEAILYALADPERAAIFAQLAGAacGRTCSALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVEMLNQTRCAE 88
Cdd:COG0640    6 ELEELAELFKALADPTRLRILRLLAEG--ELCVGELAEaLG---LSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|
gi 835683625  89 LDERFPGLIK 98
Cdd:COG0640   81 LAELLEWLLE 90
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
10-98 4.34e-14

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 62.60  E-value: 4.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835683625  10 EDIRPEAILYALADPERAAIFAQLAGAacGRTCSALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVEMLNQTRCAE 88
Cdd:COG0640    6 ELEELAELFKALADPTRLRILRLLAEG--ELCVGELAEaLG---LSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|
gi 835683625  89 LDERFPGLIK 98
Cdd:COG0640   81 LAELLEWLLE 90
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 15-77 2.79e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 57.16  E-value: 2.79e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 835683625   15 EAILYALADPERAAIFAQLAGAAcGRTCSALAEFGErvIPKSSLSNHFKVLRESGLIVSERQG 77
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE-PLTASELARRLD--ISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 16-80 3.76e-08

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 46.68  E-value: 3.76e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 835683625  16 AILYALADPERAAIFAQLAgaaCGRTC-SALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVEM 80
Cdd:NF033788   3 ELFKALADPTRLRILELLA---EGELCvCELAEaLG---LSQSAVSQHLKVLRDAGLVTSRREGRWV 63
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-79 8.38e-08

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 8.38e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 835683625  18 LYALADPERAAIFAQLAGAacGRTCSALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVE 79
Cdd:cd00090    1 LKALSDPTRLRILRLLLEG--PLTVSELAErLG---LSQSTVSRHLKKLEEAGLVESRREGRR 58
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
17-97 1.55e-07

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 44.89  E-value: 1.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835683625    17 ILYALADPERaaifaqlagaacgrTCSALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVEMLNQTRCAELDERFPG 95
Cdd:smart00418   2 ILKLLAEGEL--------------CVCELAEiLG---LSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEE 64


                   ..
gi 835683625    96 LI 97
Cdd:smart00418  65 LL 66
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
10-98 4.34e-14

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 62.60  E-value: 4.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835683625  10 EDIRPEAILYALADPERAAIFAQLAGAacGRTCSALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVEMLNQTRCAE 88
Cdd:COG0640    6 ELEELAELFKALADPTRLRILRLLAEG--ELCVGELAEaLG---LSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEA 80

                         90
                 ....*....|
gi 835683625  89 LDERFPGLIK 98
Cdd:COG0640   81 LAELLEWLLE 90
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
7-96 1.67e-12

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 58.43  E-value: 1.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835683625   7 PALEDIRPEAILYALADPERAAIFAQLAGAAcgRTCSALAE-FGervIPKSSLSNHFKVLRESGLIVSERQ----GVEML 81
Cdd:COG4189    2 VVLDDEESLEVLKALASETRLRILRLLAEEP--LNVNELAEaLG---LPKSTVSYHIRKLEEAGLIRTEYKpgkrGRQKI 76

                         90
                 ....*....|....*
gi 835683625  82 NQTRCAELDERFPGL 96
Cdd:COG4189   77 CYLRVDKILIVLPGL 91
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 15-77 2.79e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 57.16  E-value: 2.79e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 835683625   15 EAILYALADPERAAIFAQLAGAAcGRTCSALAEFGErvIPKSSLSNHFKVLRESGLIVSERQG 77
Cdd:pfam12840   1 DDVAEALADPTRLRILRALVGDE-PLTASELARRLD--ISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 16-80 3.76e-08

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 46.68  E-value: 3.76e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 835683625  16 AILYALADPERAAIFAQLAgaaCGRTC-SALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVEM 80
Cdd:NF033788   3 ELFKALADPTRLRILELLA---EGELCvCELAEaLG---LSQSAVSQHLKVLRDAGLVTSRREGRWV 63
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-79 8.38e-08

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 8.38e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 835683625  18 LYALADPERAAIFAQLAGAacGRTCSALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVE 79
Cdd:cd00090    1 LKALSDPTRLRILRLLLEG--PLTVSELAErLG---LSQSTVSRHLKKLEEAGLVESRREGRR 58
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
17-97 1.55e-07

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 44.89  E-value: 1.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 835683625    17 ILYALADPERaaifaqlagaacgrTCSALAE-FGervIPKSSLSNHFKVLRESGLIVSERQGVEMLNQTRCAELDERFPG 95
Cdd:smart00418   2 ILKLLAEGEL--------------CVCELAEiLG---LSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEE 64


                   ..
gi 835683625    96 LI 97
Cdd:smart00418  65 LL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 17-71 3.96e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 32.80  E-value: 3.96e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 835683625   17 ILYALADPERAaiFAQLAgaacgrtcsalAEFGervIPKSSLSNHFKVLRESGLI 71
Cdd:pfam01022   7 ILKLLAEGELC--VCELA-----------EELG---LSQSTVSHHLKKLREAGLV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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