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Conserved domains on  [gi|836628668|ref|WP_047778564|]
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MULTISPECIES: ATP-binding protein [Flavobacterium]

Protein Classification

ATP-binding protein( domain architecture ID 11421745)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain

EC:  3.6.1.-
Gene Ontology:  GO:0016887|GO:0005524
PubMed:  11473577

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 53-426 9.53e-81

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


:

Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 254.45  E-value: 9.53e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  53 DILLLALALVPNIHPDFLSSIIAEYLPNGGELPEFGGIKTKNHRGILPTGETAQFLIAGNHLEDRISFYNYLHNKSFLYQ 132
Cdd:COG0464   22 ALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 133 KGIIKIDSVSNGEPKLSGLLVLDDEYVEKFITGKILKPQLSSIFPAQLIETQLEWGDLVLNSTTLNNIKEIETWLKFNDI 212
Cdd:COG0464  102 LLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPE 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 213 ILNEWNmkskIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADK-DWILFFD 291
Cdd:COG0464  182 LREEYG----LPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLaPCVLFID 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 292 EADAVFGKRTNVRdahDKYANQEVSYLLQRIEN--HPGLVILASNFKANIDTAFTRRFQSIIEFEVPSYGERLRLWENNL 369
Cdd:COG0464  258 EADALAGKRGEVG---DGVGRRVVNTLLTEMEElrSDVVVIAATNRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHL 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 370 PRgIRISEDVNLNELSKK-YDITGANIVNIIQYACLKTLEDENETINLTHLLQGIKKE 426
Cdd:COG0464  335 RK-RPLDEDVDLEELAEAtEGLSGADIRNVVRRAALQALRLGREPVTTEDLLEALERE 391
 
Name Accession Description Interval E-value
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 53-426 9.53e-81

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 254.45  E-value: 9.53e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  53 DILLLALALVPNIHPDFLSSIIAEYLPNGGELPEFGGIKTKNHRGILPTGETAQFLIAGNHLEDRISFYNYLHNKSFLYQ 132
Cdd:COG0464   22 ALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 133 KGIIKIDSVSNGEPKLSGLLVLDDEYVEKFITGKILKPQLSSIFPAQLIETQLEWGDLVLNSTTLNNIKEIETWLKFNDI 212
Cdd:COG0464  102 LLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPE 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 213 ILNEWNmkskIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADK-DWILFFD 291
Cdd:COG0464  182 LREEYG----LPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLaPCVLFID 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 292 EADAVFGKRTNVRdahDKYANQEVSYLLQRIEN--HPGLVILASNFKANIDTAFTRRFQSIIEFEVPSYGERLRLWENNL 369
Cdd:COG0464  258 EADALAGKRGEVG---DGVGRRVVNTLLTEMEElrSDVVVIAATNRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHL 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 370 PRgIRISEDVNLNELSKK-YDITGANIVNIIQYACLKTLEDENETINLTHLLQGIKKE 426
Cdd:COG0464  335 RK-RPLDEDVDLEELAEAtEGLSGADIRNVVRRAALQALRLGREPVTTEDLLEALERE 391
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 211-353 1.01e-32

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 121.24  E-value: 1.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 211 DIILNEW----NMKSKIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADK-D 285
Cdd:cd19481    7 EAVEAPRrgsrLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFERARRLaP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836628668 286 WILFFDEADAVFGKRTNVrdAHDKYANQEVSYLLQRIE----NHPGLVILASNFKANIDTAFTR--RFQSIIEF 353
Cdd:cd19481   87 CILFIDEIDAIGRKRDSS--GESGELRRVLNQLLTELDgvnsRSKVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 229-355 5.54e-26

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 101.90  E-value: 5.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKDW-ILFFDEADAVFGKRTNVRDAH 307
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPcVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 836628668  308 dkyANQEVSYLLQRIE-----NHPGLVILASNFKANIDTAFTRRFQSIIEFEV 355
Cdd:pfam00004  81 ---SRRVVNQLLTELDgftssNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 216-407 1.22e-19

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 91.51  E-value: 1.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  216 EWNMKSK-------IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADK-DWI 287
Cdd:TIGR01243 470 EWPLKHPeifekmgIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAaPAI 549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  288 LFFDEADAVFGKRTNVRDAH--DKYANQEVSYLLQRIENHPGLVILASNFKANIDTAFTR--RFQSIIEFEVPSYGERLR 363
Cdd:TIGR01243 550 IFFDEIDAIAPARGARFDTSvtDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRpgRFDRLILVPPPDEEARKE 629

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 836628668  364 LWENNlPRGIRISEDVNLNELSKKYD-ITGANIVNIIQYACLKTL 407
Cdd:TIGR01243 630 IFKIH-TRSMPLAEDVDLEELAEMTEgYTGADIEAVCREAAMAAL 673
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 223-431 6.39e-16

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 79.43  E-value: 6.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAVFGKRT 301
Cdd:PTZ00361 214 IKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENApSIVFIDEIDAIGTKRY 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 302 NVRDAHDKYANQEVSYLLQRIENHPGL----VILASNFKANIDTAFTR--RFQSIIEFEVPSYGERLRLWENNLPRgIRI 375
Cdd:PTZ00361 294 DATSGGEKEIQRTMLELLNQLDGFDSRgdvkVIMATNRIESLDPALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSK-MTL 372

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 376 SEDVNLNEL-SKKYDITGANIVNIIQYACLKTLEDENETINLTHLLQGIKK-EYAKEG 431
Cdd:PTZ00361 373 AEDVDLEEFiMAKDELSGADIKAICTEAGLLALRERRMKVTQADFRKAKEKvLYRKKG 430
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 225-356 9.66e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 53.92  E-value: 9.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668   225 PGYRVMFYGAPGTGKTLTASLLGKY---TKRDVYRIDLSM--------------VISKYIGETEKNLSSLFDKAADKDW- 286
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARElgpPGGGVIYIDGEDileevldqllliivGGKKASGSGELRLRLALALARKLKPd 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 836628668   287 ILFFDEADAVFGKRTNvrdaHDKYANQEVSYLLQRIENHPGLVILASNFKANIDTAFTR-RFQSIIEFEVP 356
Cdd:smart00382  81 VLILDEITSLLDAEQE----ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRrRFDRRIVLLLI 147
 
Name Accession Description Interval E-value
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 53-426 9.53e-81

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 254.45  E-value: 9.53e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  53 DILLLALALVPNIHPDFLSSIIAEYLPNGGELPEFGGIKTKNHRGILPTGETAQFLIAGNHLEDRISFYNYLHNKSFLYQ 132
Cdd:COG0464   22 ALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLAALLSALELLLLGELLLLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 133 KGIIKIDSVSNGEPKLSGLLVLDDEYVEKFITGKILKPQLSSIFPAQLIETQLEWGDLVLNSTTLNNIKEIETWLKFNDI 212
Cdd:COG0464  102 LLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPE 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 213 ILNEWNmkskIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADK-DWILFFD 291
Cdd:COG0464  182 LREEYG----LPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLaPCVLFID 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 292 EADAVFGKRTNVRdahDKYANQEVSYLLQRIEN--HPGLVILASNFKANIDTAFTRRFQSIIEFEVPSYGERLRLWENNL 369
Cdd:COG0464  258 EADALAGKRGEVG---DGVGRRVVNTLLTEMEElrSDVVVIAATNRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHL 334

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 370 PRgIRISEDVNLNELSKK-YDITGANIVNIIQYACLKTLEDENETINLTHLLQGIKKE 426
Cdd:COG0464  335 RK-RPLDEDVDLEELAEAtEGLSGADIRNVVRRAALQALRLGREPVTTEDLLEALERE 391
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
209-433 2.42e-45

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 157.35  E-value: 2.42e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 209 FNDIILNEwNMKSKIK------------------PGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGET 270
Cdd:COG1223    1 LDDVVGQE-EAKKKLKliikelrrrenlrkfglwPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGET 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 271 EKNLSSLFDKAADKDWILFFDEADAVFGKRtnvRDAHD-KYANQEVSYLLQRIENHPG--LVILASNFKANIDTAFTRRF 347
Cdd:COG1223   80 ARNLRKLFDFARRAPCVIFFDEFDAIAKDR---GDQNDvGEVKRVVNALLQELDGLPSgsVVIAATNHPELLDSALWRRF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 348 QSIIEFEVPSYGERLRLWENNLpRGIRISEDVNLNELSKKY-DITGANIVNIIQYACLKTLEDENETINLTHLLQGIKKE 426
Cdd:COG1223  157 DEVIEFPLPDKEERKEILELNL-KKFPLPFELDLKKLAKKLeGLSGADIEKVLKTALKKAILEDREKVTKEDLEEALKQR 235


                 ....*..
gi 836628668 427 YAKEGKM 433
Cdd:COG1223  236 KERKKEP 242
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 223-425 2.11e-44

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 157.48  E-value: 2.11e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAVFGKRT 301
Cdd:COG1222  109 IEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKApSIIFIDEIDAIAARRT 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 302 NVRDAHDkyANQEVSYLLQRIE----NHPGLVILASNFKANIDTAFTR--RFQSIIEFEVPSYGERLRLWENNLpRGIRI 375
Cdd:COG1222  189 DDGTSGE--VQRTVNQLLAELDgfesRGDVLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHL-RDMPL 265

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 836628668 376 SEDVNLNELSKKYD-ITGANIVNIIQYACLKTLEDENETINLTHLLQGIKK 425
Cdd:COG1222  266 ADDVDLDKLAKLTEgFSGADLKAIVTEAGMFAIREGRDTVTMEDLEKAIEK 316
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 211-353 1.01e-32

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 121.24  E-value: 1.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 211 DIILNEW----NMKSKIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADK-D 285
Cdd:cd19481    7 EAVEAPRrgsrLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFERARRLaP 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836628668 286 WILFFDEADAVFGKRTNVrdAHDKYANQEVSYLLQRIE----NHPGLVILASNFKANIDTAFTR--RFQSIIEF 353
Cdd:cd19481   87 CILFIDEIDAIGRKRDSS--GESGELRRVLNQLLTELDgvnsRSKVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 229-355 5.54e-26

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 101.90  E-value: 5.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKDW-ILFFDEADAVFGKRTNVRDAH 307
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPcVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 836628668  308 dkyANQEVSYLLQRIE-----NHPGLVILASNFKANIDTAFTRRFQSIIEFEV 355
Cdd:pfam00004  81 ---SRRVVNQLLTELDgftssNSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 216-407 1.22e-19

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 91.51  E-value: 1.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  216 EWNMKSK-------IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADK-DWI 287
Cdd:TIGR01243 470 EWPLKHPeifekmgIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKAIREIFRKARQAaPAI 549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  288 LFFDEADAVFGKRTNVRDAH--DKYANQEVSYLLQRIENHPGLVILASNFKANIDTAFTR--RFQSIIEFEVPSYGERLR 363
Cdd:TIGR01243 550 IFFDEIDAIAPARGARFDTSvtDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRpgRFDRLILVPPPDEEARKE 629

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 836628668  364 LWENNlPRGIRISEDVNLNELSKKYD-ITGANIVNIIQYACLKTL 407
Cdd:TIGR01243 630 IFKIH-TRSMPLAEDVDLEELAEMTEgYTGADIEAVCREAAMAAL 673
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 223-353 4.57e-19

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 83.88  E-value: 4.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKA-ADKDWILFFDEADAVFGKRT 301
Cdd:cd19503   31 LKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKNLREIFEEArSHAPSIIFIDEIDALAPKRE 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 836628668 302 NVRDAHDKYANQEVSYLLQRIENHPG-LVILASNFKANIDTAFTR--RFQSIIEF 353
Cdd:cd19503  111 EDQREVERRVVAQLLTLMDGMSSRGKvVVIAATNRPDAIDPALRRpgRFDREVEI 165
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 223-407 6.32e-18

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 86.11  E-value: 6.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADK-DWILFFDEADAVFGKRT 301
Cdd:TIGR01243 209 IEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENaPSIIFIDEIDAIAPKRE 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  302 NVRDAHDKyanQEVSYLLQRIENHPG----LVILASNFKANIDTAFTR--RFQSIIEFEVPSYGER---LRLWENNLPrg 372
Cdd:TIGR01243 289 EVTGEVEK---RVVAQLLTLMDGLKGrgrvIVIGATNRPDALDPALRRpgRFDREIVIRVPDKRARkeiLKVHTRNMP-- 363

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 836628668  373 irISEDVNLNELSK-KYDITGANIVNIIQYACLKTL 407
Cdd:TIGR01243 364 --LAEDVDLDKLAEvTHGFVGADLAALAKEAAMAAL 397
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 223-351 3.07e-17

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 78.48  E-value: 3.07e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAAD-KDWILFFDEADAVFGKRT 301
Cdd:cd19511   24 IRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKARQaAPCIIFFDEIDSLAPRRG 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 836628668 302 NVRDahDKYANQEVSYLLQR---IENHPGLVIL-ASNFKANIDTAFTR--RFQSII 351
Cdd:cd19511  104 QSDS--SGVTDRVVSQLLTEldgIESLKGVVVIaATNRPDMIDPALLRpgRLDKLI 157
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 229-348 2.22e-16

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 76.24  E-value: 2.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAAD-KDWILFFDEADAVFGKRTNVRDAH 307
Cdd:cd19509   35 ILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIVRALFALARElQPSIIFIDEIDSLLSERGSGEHEA 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 836628668 308 DKYANQEVSYLLQRIENHPG---LVILASNFKANIDTAFTRRFQ 348
Cdd:cd19509  115 SRRVKTEFLVQMDGVLNKPEdrvLVLGATNRPWELDEAFLRRFE 158
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 223-431 6.39e-16

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 79.43  E-value: 6.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAVFGKRT 301
Cdd:PTZ00361 214 IKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENApSIVFIDEIDAIGTKRY 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 302 NVRDAHDKYANQEVSYLLQRIENHPGL----VILASNFKANIDTAFTR--RFQSIIEFEVPSYGERLRLWENNLPRgIRI 375
Cdd:PTZ00361 294 DATSGGEKEIQRTMLELLNQLDGFDSRgdvkVIMATNRIESLDPALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSK-MTL 372

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 376 SEDVNLNEL-SKKYDITGANIVNIIQYACLKTLEDENETINLTHLLQGIKK-EYAKEG 431
Cdd:PTZ00361 373 AEDVDLEEFiMAKDELSGADIKAICTEAGLLALRERRMKVTQADFRKAKEKvLYRKKG 430
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 197-352 1.44e-15

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 74.01  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 197 LNNIKE-IETWLKFNDIIlnewnMKSKIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLS 275
Cdd:cd19519    9 LAQIREmVELPLRHPELF-----KAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 276 SLFDKAADKD-WILFFDEADAVFGKRtnvRDAHDKYANQEVSYLLQRIENHPG----LVILASNFKANIDTAFTR--RFQ 348
Cdd:cd19519   84 KAFEEAEKNApAIIFIDEIDAIAPKR---EKTHGEVERRIVSQLLTLMDGLKQrahvIVMAATNRPNSIDPALRRfgRFD 160


                 ....
gi 836628668 349 SIIE 352
Cdd:cd19519  161 REID 164
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 230-358 4.77e-15

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 77.19  E-value: 4.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668  230 MFYGAPGTGKTLTASLLGKY----------TKRDVYRIDLsmvISKYIGETEKNLSSLFDKAADKdwILFFDEADAVFGK 299
Cdd:TIGR03922 316 LFAGPPGTGKTTIARVVAKIycglgvlrkpLVREVSRADL---IGQYIGESEAKTNEIIDSALGG--VLFLDEAYTLVET 390

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 836628668  300 RTNvrdAHDKYANQEVSYLLQRIENHPG-LVILASNFKANIDTAFT------RRFQSIIEFevPSY 358
Cdd:TIGR03922 391 GYG---QKDPFGLEAIDTLLARMENDRDrLVVIGAGYRKDLDKFLEvneglrSRFTRVIEF--PSY 451
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 223-353 8.13e-15

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 71.98  E-value: 8.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAVFGKRT 301
Cdd:cd19502   34 IEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEGARLVRELFEMAREKApSIIFIDEIDAIGAKRF 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 302 NVRDAHDKYANQEVSYLLQRIENHPGL----VILASNFKANIDTAFTR--RFQSIIEF 353
Cdd:cd19502  114 DSGTGGDREVQRTMLELLNQLDGFDPRgnikVIMATNRPDILDPALLRpgRFDRKIEF 171
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 229-352 1.60e-14

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 71.37  E-value: 1.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKY-TKRDVYRIDLSMVISKYIGETEKNLSSLFdKAADKDW----------ILFFDEADAVF 297
Cdd:cd19504   38 ILLYGPPGTGKTLMARQIGKMlNAREPKIVNGPEILNKYVGESEANIRKLF-ADAEEEQrrlgansglhIIIFDEIDAIC 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836628668 298 GKRTNVRDA---HDKYANQevsyLLQRIEN----HPGLVILASNFKANIDTAFTR--RFQSIIE 352
Cdd:cd19504  117 KQRGSMAGStgvHDTVVNQ----LLSKIDGveqlNNILVIGMTNRKDLIDEALLRpgRLEVQME 176
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 198-351 5.39e-14

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 69.45  E-value: 5.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 198 NNIKEIETW-LKFNDIIlnewnMKSKIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSS 276
Cdd:cd19529    3 QELKEAVEWpLLKPEVF-----KRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIRE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 277 LFDKAAD-KDWILFFDEADAVFGKRTNVRDAH--DKYANQEVSYLLQRIENHPGLVILASNFKANIDTAFTR--RFQSII 351
Cdd:cd19529   78 IFRKARQvAPCVIFFDEIDSIAPRRGTTGDSGvtERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRagRFDRLI 157
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 229-425 7.39e-14

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 72.56  E-value: 7.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAVFGKRTNVRDAH 307
Cdd:PRK03992 168 VLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFIGEGARLVRELFELAREKApSIIFIDEIDAIAAKRTDSGTSG 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 308 DKYANQEVSYLLQRIEnhpGL-------VILASNFKANIDTAFTR--RFQSIIEFEVPSYGERLRLWENNLpRGIRISED 378
Cdd:PRK03992 248 DREVQRTLMQLLAEMD---GFdprgnvkIIAATNRIDILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHT-RKMNLADD 323

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 836628668 379 VNLNELSKKYD-ITGANIVNIIQYACLKTLEDENETINLTHLLQGIKK 425
Cdd:PRK03992 324 VDLEELAELTEgASGADLKAICTEAGMFAIRDDRTEVTMEDFLKAIEK 371
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 216-347 1.79e-13

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 68.30  E-value: 1.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 216 EWNMKSKIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSM-----VISKYIGETEKNLSSLFDKA-ADKDWILF 289
Cdd:cd19517   24 EVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKGGQKVSFFMrkgadCLSKWVGEAERQLRLLFEEAyRMQPSIIF 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836628668 290 FDEADAVFGKRTNvrdAHDKYANQEVSYLLQRIENHPG----LVILASNFKANIDTAFTR--RF 347
Cdd:cd19517  104 FDEIDGLAPVRSS---KQEQIHASIVSTLLALMDGLDNrgqvVVIGATNRPDALDPALRRpgRF 164
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 219-345 5.66e-13

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 66.38  E-value: 5.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 219 MKSKIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKA-ADKDWILFFDEADAVF 297
Cdd:cd19528   20 LKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKArAAAPCVLFFDELDSIA 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 836628668 298 GKR-TNVRD---AHDKYANQEVSYLLQRIENHPGLVILASNFKANIDTAFTR 345
Cdd:cd19528  100 KARgGNIGDaggAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILR 151
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 223-402 6.05e-13

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 69.79  E-value: 6.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAVFGKRT 301
Cdd:PTZ00454 176 IDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENApSIIFIDEVDSIATKRF 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 302 NVRDAhdkyANQEVSYLLQRIENH-PGL-------VILASNFKANIDTAFTR--RFQSIIEFEVPSYGERlRLWENNLPR 371
Cdd:PTZ00454 256 DAQTG----ADREVQRILLELLNQmDGFdqttnvkVIMATNRADTLDPALLRpgRLDRKIEFPLPDRRQK-RLIFQTITS 330

                        170       180       190
                 ....*....|....*....|....*....|..
gi 836628668 372 GIRISEDVNLNE-LSKKYDITGANIVNIIQYA 402
Cdd:PTZ00454 331 KMNLSEEVDLEDfVSRPEKISAADIAAICQEA 362
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 229-351 3.59e-12

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 64.07  E-value: 3.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAAD-KDWILFFDEADAVFGKRTNVRDAh 307
Cdd:cd19527   29 ILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKARDaKPCVIFFDELDSLAPSRGNSGDS- 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 836628668 308 DKYANQEVSYLLQRIENHPG-----LVILASNFKANIDTAFTR--RFQSII 351
Cdd:cd19527  108 GGVMDRVVSQLLAELDGMSSsgqdvFVIGATNRPDLLDPALLRpgRFDKLL 158
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 208-353 4.39e-12

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 63.70  E-value: 4.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 208 KFNDIILNEWNMKSKIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDvYRIDLSMVISKYIGETEKNLSSLFD--KAADKD 285
Cdd:cd19512    4 RVRDIAIATRNTKKNKGLYRNILFYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAIHKVFDwaNTSRRG 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 286 WILFFDEADAVFGKRTNVRDAHDKYANqeVSYLLQRIENHPG--LVILASNFKANIDTAFTRRFQSIIEF 353
Cdd:cd19512   83 LLLFVDEADAFLRKRSTEKISEDLRAA--LNAFLYRTGEQSNkfMLVLASNQPEQFDWAINDRIDEMVEF 150
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 229-345 1.05e-11

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 62.83  E-value: 1.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKA-ADKDWILFFDEADAVFGKR----TNV 303
Cdd:cd19526   30 ILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRAqSAKPCILFFDEFDSIAPKRghdsTGV 109

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 836628668 304 RdahDKYANQEVSYlLQRIENHPGLVILASNFKAN-IDTAFTR 345
Cdd:cd19526  110 T---DRVVNQLLTQ-LDGVEGLDGVYVLAATSRPDlIDPALLR 148
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 223-351 1.22e-11

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 62.81  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 223 IKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKA-ADKDWILFFDEADAVFGKRT 301
Cdd:cd19518   31 VEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEKIRELFDQAiSNAPCIVFIDEIDAITPKRE 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 836628668 302 NV-RDAHDKYANQEVSYL----LQRIENHPGLVILASNFKANIDTAFTR--RFQSII 351
Cdd:cd19518  111 SAqREMERRIVSQLLTCMdelnNEKTAGGPVLVIGATNRPDSLDPALRRagRFDREI 167
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 224-351 1.28e-11

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 62.96  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 224 KPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAAD-KDWILFFDEADAVFGKRTN 302
Cdd:cd19521   38 KPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLVKQLFAMAREnKPSIIFIDEVDSLCGTRGE 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 836628668 303 VRDAHDKYANQEVSYLLQRIENHPG--LVILASNFKANIDTAFTRRFQSII 351
Cdd:cd19521  118 GESEASRRIKTELLVQMNGVGNDSQgvLVLGATNIPWQLDSAIRRRFEKRI 168
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 184-348 2.26e-11

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 62.31  E-value: 2.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 184 QLEWGDLVLNSTTLNNIKEIETW-LKFNDIIlnewnmkSKIK-PGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSM 261
Cdd:cd19525   18 PINWADIAGLEFAKKTIKEIVVWpMLRPDIF-------TGLRgPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 262 VISKYIGETEKNLSSLFDKAADK-DWILFFDEADAVFGKRTNVRDAHDKYANQEVSYLLQRIENHPG---LVILASNFKA 337
Cdd:cd19525   91 LTSKWVGEGEKMVRALFSVARCKqPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEdriLVVGATNRPQ 170

                        170
                 ....*....|.
gi 836628668 338 NIDTAFTRRFQ 348
Cdd:cd19525  171 EIDEAARRRLV 181
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 224-351 8.72e-11

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 60.38  E-value: 8.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 224 KPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKA-ADKDWILFFDEADAVFGKRtN 302
Cdd:cd19522   31 RPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMArFYAPTTIFIDEIDSICSRR-G 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 836628668 303 VRDAHDkyANQEV-SYLLQRIENHPG-----------LVILASNFKANIDTAFTRRFQSII 351
Cdd:cd19522  110 TSEEHE--ASRRVkSELLVQMDGVGGasenddpskmvMVLAATNFPWDIDEALRRRLEKRI 168
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 229-346 1.08e-09

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 57.05  E-value: 1.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAAD-KDWILFFDEADAVFGKRTnvRDAH 307
Cdd:cd19520   38 VLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQKLVAAVFSLASKlQPSIIFIDEIDSFLRQRS--STDH 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 836628668 308 DKYANQEVSYL-----LQRIENHPGLVILASNFKANIDTAFTRR 346
Cdd:cd19520  116 EATAMMKAEFMslwdgLSTDGNCRVIVMGATNRPQDLDEAILRR 159
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 229-354 2.28e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 56.00  E-value: 2.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKR---DVYRIDLSMVISKYIGETEKNLSS---LFDKAADKDW-ILFFDEADAVFgkrt 301
Cdd:cd00009   22 LLLYGPPGTGKTTLARAIANELFRpgaPFLYLNASDLLEGLVVAELFGHFLvrlLFELAEKAKPgVLFIDEIDSLS---- 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 836628668 302 nvRDAHDKYANQEVSYLLQRIENHPGLVILASNFKANIDT--AFTRRFQSIIEFE 354
Cdd:cd00009   98 --RGAQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLdrALYDRLDIRIVIP 150
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 229-345 2.61e-09

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 55.96  E-value: 2.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAVFGKRTN-VRDA 306
Cdd:cd19530   33 VLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQRARASApCVIFFDEVDALVPKRGDgGSWA 112

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 836628668 307 HDKYANQEVSYLLQRIENHPGLVILASNFKANIDTAFTR 345
Cdd:cd19530  113 SERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLR 151
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 225-347 6.29e-09

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 54.86  E-value: 6.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 225 PGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAAD-KDWILFFDEADAVFGKRTNv 303
Cdd:cd19524   32 PARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARElQPSIIFIDEVDSLLSERSE- 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 836628668 304 rDAHDKYANQEVSYLLQ--RIENHPG---LVILASNFKANIDTAFTRRF 347
Cdd:cd19524  111 -GEHEASRRLKTEFLIEfdGVQSNGDdrvLVMGATNRPQELDDAVLRRF 158
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 225-356 9.66e-09

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 53.92  E-value: 9.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668   225 PGYRVMFYGAPGTGKTLTASLLGKY---TKRDVYRIDLSM--------------VISKYIGETEKNLSSLFDKAADKDW- 286
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARElgpPGGGVIYIDGEDileevldqllliivGGKKASGSGELRLRLALALARKLKPd 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 836628668   287 ILFFDEADAVFGKRTNvrdaHDKYANQEVSYLLQRIENHPGLVILASNFKANIDTAFTR-RFQSIIEFEVP 356
Cdd:smart00382  81 VLILDEITSLLDAEQE----ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRrRFDRRIVLLLI 147
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
222-434 7.58e-08

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 54.66  E-value: 7.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 222 KIKPGyrVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAAD-KDWILFFDEADAVFGKR 300
Cdd:PRK10733 183 KIPKG--VLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKaAPCIIFIDEIDAVGRQR 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 301 -TNVRDAHDKyANQEVSYLLQRIENHPG----LVILASNFKANIDTAFTR--RFQSIIEFEVPSYGERLRLWENNLPRgI 373
Cdd:PRK10733 261 gAGLGGGHDE-REQTLNQMLVEMDGFEGnegiIVIAATNRPDVLDPALLRpgRFDRQVVVGLPDVRGREQILKVHMRR-V 338

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 836628668 374 RISEDVNLNELSKKY-DITGANIVNIIQYACLKTLEDENETINLthllqgIKKEYAKEGKMM 434
Cdd:PRK10733 339 PLAPDIDAAIIARGTpGFSGADLANLVNEAALFAARGNKRVVSM------VEFEKAKDKIMM 394
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 229-346 1.01e-07

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 52.06  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKT---------LTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDK----AADKDWILF--FDEA 293
Cdd:cd19508   55 VLLHGPPGTGKTslckalaqkLSIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKiqelIDDKDALVFvlIDEV 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 294 DAVFGKRTNVRDAHDKY-ANQEVSYLLQRIEN----HPGLVILASNFKANIDTAFTRR 346
Cdd:cd19508  135 ESLAAARSASSSGTEPSdAIRVVNAVLTQIDRikryHNNVILLTSNLLEKIDVAFVDR 192
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 197-306 1.18e-07

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 51.22  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 197 LNNIKEietWLKFNDIILNEWNMKSKIKPGYRVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSS 276
Cdd:cd19507    5 LDNLKD---WLKKRKAAFSKQASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQ 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 836628668 277 LFDKA-ADKDWILFFDEADAVFGKRTNVRDA 306
Cdd:cd19507   82 MIQTAeAIAPCVLWIDEIEKGFSNADSKGDS 112
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 218-347 1.08e-06

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 48.38  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 218 NMKSKIKPGyrVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAV 296
Cdd:cd19501   31 KLGAKIPKG--VLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNApCIVFIDEIDAV 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 297 FGKR-TNVRDAHDkYANQEVSYLLQRI---ENHPGLVILASNFKANI-DTAFTR--RF 347
Cdd:cd19501  109 GRKRgAGLGGGHD-EREQTLNQLLVEMdgfESNTGVIVIAATNRPDVlDPALLRpgRF 165
ftsH CHL00176
cell division protein; Validated
 229-415 1.69e-05

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 46.97  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMVISKYIGETEKNLSSLFDKAADKD-WILFFDEADAVFGKR-TNV--- 303
Cdd:CHL00176 219 VLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVGVGAARVRDLFKKAKENSpCIVFIDEIDAVGRQRgAGIggg 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 304 RDAHDKYANQEVSYlLQRIENHPGLVILASNFKANI-DTAFTR--RFQSIIEFEVPSYGER---LRLWENNLPrgirISE 377
Cdd:CHL00176 299 NDEREQTLNQLLTE-MDGFKGNKGVIVIAATNRVDIlDAALLRpgRFDRQITVSLPDREGRldiLKVHARNKK----LSP 373

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 836628668 378 DVNLNELSKKY-DITGANIVNIIQYACLKTLEDENETIN 415
Cdd:CHL00176 374 DVSLELIARRTpGFSGADLANLLNEAAILTARRKKATIT 412
cbbX CHL00181
CbbX; Provisional
 225-340 7.15e-05

CbbX; Provisional


Pssm-ID: 177083 [Multi-domain]  Cd Length: 287  Bit Score: 44.32  E-value: 7.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 225 PGYRVMFYGAPGTGKTLT----ASLLGK--YTKR----DVYRIDLsmvISKYIGETEKNLSSLFDKAADKdwILFFDEAD 294
Cdd:CHL00181  58 PGLHMSFTGSPGTGKTTValkmADILYKlgYIKKghllTVTRDDL---VGQYIGHTAPKTKEVLKKAMGG--VLFIDEAY 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 836628668 295 AVFgKRTNVRDahdkYANQEVSYLLQRIENH-PGLVILASNFKANID 340
Cdd:CHL00181 133 YLY-KPDNERD----YGSEAIEILLQVMENQrDDLVVIFAGYKDRMD 174
PRK04195 PRK04195
replication factor C large subunit; Provisional
 189-299 8.66e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 44.53  E-value: 8.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 189 DLVLNSTTLNNIKE-IETWLKfndiilnewnmKSKIKPgyrVMFYGAPGTGKTLTASLLGKYTKRDVYRIDLS-----MV 262
Cdd:PRK04195  15 DVVGNEKAKEQLREwIESWLK-----------GKPKKA---LLLYGPPGVGKTSLAHALANDYGWEVIELNASdqrtaDV 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 836628668 263 ISKYIGETEKNlSSLFDKaadKDWILFFDEADAVFGK 299
Cdd:PRK04195  81 IERVAGEAATS-GSLFGA---RRKLILLDEVDGIHGN 113
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 229-292 7.99e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 41.61  E-value: 7.99e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 836628668 229 VMFYGAPGTGKTLTASLLGKYTKRDVYRidLSMVISKYigeteKNLSSLFDKA-----ADKDWILFFDE 292
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEA--LSAVTSGV-----KDLREVIEEArqrrsAGRRTILFIDE 100
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 224-346 1.94e-03

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 38.49  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836628668 224 KPGYrvMFYGAPGTGKTLTASLLGKYTKRDVYRIDLSMViskyiGETEKNLSSLFDKAADKDwILFFDEADAVFGKRTNV 303
Cdd:cd19510   23 RRGY--LLYGPPGTGKSSFIAALAGELDYDICDLNLSEV-----VLTDDRLNHLLNTAPKQS-IILLEDIDAAFESREHN 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 836628668 304 RDAHDKYANQE---VSYLL----------QRIenhpglVILASNFKANIDTAFTRR 346
Cdd:cd19510   95 KKNPSAYGGLSrvtFSGLLnaldgvasseERI------VFMTTNHIERLDPALIRP 144
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 231-292 2.24e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 40.04  E-value: 2.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 836628668 231 FYGAPGTGKTLTASLLGKYTKRDVYRidLSMVIS------KYIGETEKNLSSlfdkaaDKDWILFFDE 292
Cdd:COG2256   54 LWGPPGTGKTTLARLIANATDAEFVA--LSAVTSgvkdirEVIEEARERRAY------GRRTILFVDE 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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