phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 836692403   8 LVSIVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITA 86
Cdd:cd17537    2 TVYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403   11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITAFASG 90
Cdd:pfam00072   3 IVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGDE 82

                          90       100
                  ....*....|....*....|....
gi 836692403   91 RTLERASASRALCVIDKPIDASEL 114
Cdd:pfam00072  83 DDAVEALEAGADDFLSKPFDPDEL 106

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 836692403   8 LVSIVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITA 86
Cdd:cd17537    2 TVYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITG 80

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLAsdtLAATG---CLVCDVQMPGTDGVELLSLLEARGIL--IPTVFIT 85
Cdd:COG0784   10 VVDDNPDNRELLRRLLERLGYEVTTAEDGAEALE---LLRAGppdLILLDINMPGMDGLELLRRIRALPRLpdIPIIALT 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 836692403  86 AFASGRTLERASASRALCVIDKPIDASELESWIGRALG 123
Cdd:COG0784   87 AYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLA 124

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITAFASG 90
Cdd:cd00156    2 IVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKADE 81

                         90
                 ....*....|....*...
gi 836692403  91 RTLERASASRALCVIDKP 108
Cdd:cd00156   82 EDAVRALELGADDYLVKP 99

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403   11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITAFASG 90
Cdd:pfam00072   3 IVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGDE 82

                          90       100
                  ....*....|....*....|....
gi 836692403   91 RTLERASASRALCVIDKPIDASEL 114
Cdd:pfam00072  83 DDAVEALEAGADDFLSKPFDPDEL 106

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLAsdtLAATG---CLVCDVQMPGTDGVELLSLLEARGILIPTVFITAF 87
Cdd:COG0745    6 VVEDDPDIRELLADALEREGYEVDTAADGEEALE---LLEEErpdLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTAR 82

                         90       100
                 ....*....|....*....|....*..
gi 836692403  88 ASGRTLERASASRALCVIDKPIDASEL 114
Cdd:COG0745   83 DDEEDRVRGLEAGADDYLTKPFDPEEL 109

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403   9 VSIVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITAFA 88
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGHG 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 836692403  89 SGRTLERASASRALCVIDKPIDASELESWIGRAL 122
Cdd:cd17549   81 DVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRAL 114

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403   9 VSIVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGC--LVCDVQMPGTDGVELLSLLEARGILIPTVFITA 86
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPdvVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80

                         90       100
                 ....*....|....*....|....*...
gi 836692403  87 FASGRTLERASASRALCVIDKPIDASEL 114
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEEL 108

acetoacetate metabolism transcriptional regulator AtoC;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403   7 QLVSIVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITA 86
Cdd:PRK11361   5 NRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTA 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 836692403  87 FASGRTLERASASRALCVIDKPIDASELESWIGRALGL 124
Cdd:PRK11361  85 YAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQL 122

sigma-54-dependent response regulator transcription factor ZraR;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITAFASG 90
Cdd:PRK10365  10 VVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSSV 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 836692403  91 RTLERASASRALCVIDKPIDASELESWIGRAL 122
Cdd:PRK10365  90 ETAVEALKTGALDYLIKPLDFDNLQATLEKAL 121

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITAFASG 90
Cdd:COG4567    9 LVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLTGYASI 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 836692403  91 RTLERASASRALCVIDKPIDASELESWIGRALGLWPGPPAT 131
Cdd:COG4567   89 ATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAPPEN 129

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSF-GWNARVFAT----ADEFLAS---DtlaatgCLVCDVQMPGTDGVELLSLLEARGILIPTV 82
Cdd:COG4753    4 IVDDEPLIREGLKRILEWEaGFEVVGEAEngeeALELLEEhkpD------LVITDINMPGMDGLELLEAIRELDPDTKII 77

                         90       100
                 ....*....|....*....|....*.
gi 836692403  83 FITAFASGRTLERASASRALCVIDKP 108
Cdd:COG4753   78 ILSGYSDFEYAQEAIKLGADDYLLKP 103

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLAsdtLAATG---CLVCDVQMPGTDGVELLSLLEARGILIPTVFITA 86
Cdd:cd17574    2 VVEDDEEIAELLSDYLEKEGYEVDTAADGEEALE---LAREEqpdLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTA 77

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGwNARVFATADEFLASDTLAATGC--LVCDVQMPGTDGVELLSLLEAR--GILIPTVFITA 86
Cdd:cd17551    5 IVDDNPTNLLLLEALLRSAG-YLEVVSFTDPREALAWCRENPPdlILLDYMMPGMDGLEFIRRLRALpgLEDVPIVMITA 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 836692403  87 fasgrTLERASASRALC--VID---KPIDASEL 114
Cdd:cd17551   84 -----DTDREVRLRALEagATDfltKPFDPVEL 111

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFItafaSG 90
Cdd:cd17550    3 IVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMI----SG 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 836692403  91 R-TLERA-SASR--ALCVIDKPIDASELESWIGRAL 122
Cdd:cd17550   79 HgTIETAvKATKlgAYDFIEKPLSLDRLLLTIERAL 114

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403   9 VSIVDDDPFVRA-ATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITAF 87
Cdd:cd17530    3 VLVLDDDPFQCMmAATILEDLGPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMSGL 82

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 836692403  88 ASG-----RTLERASASRALCVIDKPIDASELESWIGRA 121
Cdd:cd17530   83 DGGilesaETLAGANGLNLLGTLSKPFSPEELTELLTKY 121

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLL--EARGILIPTVFITAFA 88
Cdd:cd17580    3 VVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLreLPWLANTPAIALTGYG 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 836692403  89 SGRTLERASAS--RALCVidKPIDASELES 116
Cdd:cd17580   83 QPEDRERALEAgfDAHLV--KPVDPDELIE 110

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGIL--IPTVFITAFA 88
Cdd:cd17548    4 IVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEDPATrdIPVIALTAYA 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 836692403  89 SGRTLERASAsrALCV--IDKPIDASELESWIGR 120
Cdd:cd17548   84 MKGDREKILE--AGCDgyISKPIDTREFLETVAK 115

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403   9 VSIVDDDPFVRAATSSLVRSFGWNARVFATADEflASDTLAATGC----LVCDVQMPGTDGVELLSLLeaRGIL-IPTVF 83
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEE--ALSMLRENKDefdlVITDVHMPDMDGFEFLELI--RLEMdLPVIM 76

                         90       100       110
                 ....*....|....*....|....*....|.
gi 836692403  84 ITAFASGRTLERASASRALCVIDKPIDASEL 114
Cdd:cd17584   77 MSADGSTSTVMKGLAHGACDYLLKPVSIEDL 107

transcriptional regulator TctD;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  38 TADEFLASDTLAAtgcLVCDVQMPGTDGVELLSLLEARGILIPTVFITAFASGRTLERASASRALCVIDKPIDASELESW 117
Cdd:PRK15479  35 AADHLLQSEMYAL---AVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTARSAVADRVKGLNVGADDYLPKPFELEELDAR 111

                 ....*
gi 836692403 118 IgRAL 122
Cdd:PRK15479 112 L-RAL 115

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403   9 VSIVDDDPFVRAATSSLVRSFGWNARVFATADEflASDTLAAT---GCLVCDVQMPG-TDGVELLSLLEARGILIPTVFI 84
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDE--ALDLLESGpdiDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLLT 78

                 ....
gi 836692403  85 TAFA 88
Cdd:cd18161   79 SGYA 82

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 836692403   9 VSIVDDDPFVRAATSSLVRSFGWNARVFATADEFLASDTLAATGCLVCDVQMPGTDGVELLSLLEARGILiPTVFITA 86
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTL-PVIFLTS 77

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 836692403  54 LVC-DVQMPGTDGVELLSLLEARGILIPTVFITAFASGRTLERASASRALCVidKPIDASELESWIGRA 121
Cdd:cd17554   47 LVIlDIKMPGMDGLETLRKIREKKPDLPVIICTAYSEYKSDFSSWAADAYVV--KSSDLTELKETIKRL 113

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNArVFAT----ADEFLASDTLAAtgcLVCDVQMPGTDGVELLS 70
Cdd:cd17569    5 LVDDEPNILKALKRLLRREGYEV-LTATsgeeALEILKQEPVDV---VISDQRMPGMDGAELLK 64

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWNARVFAT---ADEFLASDTLAAtgcLVCDVQMPGTDGVELLSLLEARGILIPTVFITA 86
Cdd:cd17624    3 LVEDDALLGDGLKTGLRKAGYAVDWVRTgaeAEAALASGPYDL---VILDLGLPDGDGLDLLRRWRRQGQSLPVLILTA 78

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFgWNARVFATADEflASDTLAA-----TGCLVCDVQMPGTDGVELLSLLEARGILIPTVFIT 85
Cdd:cd17532    3 IVDDEPLAREELRYLLEEH-PDIEIVGEAEN--GEEALEAieelkPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 836692403  86 AFasgrtleRASASRA--LCVID---KPIDASELESWIGRA 121
Cdd:cd17532   80 AY-------DEYAVEAfeLNAVDyllKPFSEERLAEALAKL 113

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 836692403     9 VSIVDDDPFVRAATSSLVRSFGWNARVFATADEFLAsdtLAATG---CLVCDVQMP 61
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALE---LLKEEkpdLILLDIMMP 55

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 836692403  11 IVDDDPFVRAATSSLVRSFGWnaRVFATADEFLASD--TLAATGCLVCDVQMPGTDGVELLSLLEARGILIPTVFITAFA 88
Cdd:cd17553    5 IVDDQYGIRILLNEVFNKEGY--QTFQAANGLQALDivTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYG 82

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 836692403  89 SGRTLERASASRALCVIDKPIDASELESWIGRALG 123
Cdd:cd17553   83 ELDMIQESKELGALTHFAKPFDIDEIRDAVKKYLP 117