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Conserved domains on  [gi|850308844|ref|WP_048009035|]
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MULTISPECIES: FADH(2)-oxidizing methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase TrmFO [Bacillaceae]

Protein Classification

methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO( domain architecture ID 10787361)

methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO modifies tRNA containing uridine at position 54 to form a 5-methyluridine (ribothymidine)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmFO COG1206
Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and ...
 6-435 0e+00

Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and biogenesis]; Folate-dependent tRNA-U54 methylase TrmFO/GidA is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440819  Cd Length: 436  Bit Score: 927.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVLKEEMRKLNSVIIHSAD 85
Cdd:COG1206    4 VTVIGGGLAGSEAAWQLAERGVPVRLYEMRPVKMTPAHKTDGFAELVCSNSLRSDDLTNAVGLLKEEMRRLGSLIMAAAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  86 SSAVPAGGALAVDRHDFAARVTEQVKNHPNVTVINEEVTDIPE-GPTVIATGPLTSEALSAKLKELSGEDYLYFYDAAAP 164
Cdd:COG1206   84 AHRVPAGGALAVDREGFSAAVTEKLENHPNITVVREEVTEIPEdGPVIIATGPLTSDALAEAIQELTGEEYLYFYDAIAP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 165 ILEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALTSAETVPLKEFEKEIFFEGCMPIEVMANRGKKTMLFGP 244
Cdd:COG1206  164 IVDADSIDMDKAFRASRYDKGEADYLNCPMTKEEYEAFYEALLAAEKVELKDFEKEKYFEGCLPIEVMARRGRDTLRFGP 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 245 MKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKVLRA 324
Cdd:COG1206  244 MKPVGLTDPRTGKRPYAVVQLRQENAEGTLYNLVGFQTKLKWGEQKRVFRMIPGLENAEFVRYGVMHRNTFINSPKLLDP 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 325 TYQFKNRDDLFFAGQMTGVEGYVESAASGLVAGINAARLVAGEDPIEFPHETAIGSMARYITTANPKSFQPMNANFGLFP 404
Cdd:COG1206  324 TLQLKARPNLFFAGQITGVEGYVESAASGLLAGINAARLLLGKEPVPPPPTTALGALLNYITGADPKDFQPMNVNFGLLP 403

                        410       420       430
                 ....*....|....*....|....*....|.
gi 850308844 405 DLPEKIRGKKERNEKHAERALGTIQNFVKNL 435
Cdd:COG1206  404 PLEKRIRDKKERKEAYAERALEDLEAWLAEL 434
 
Name Accession Description Interval E-value
TrmFO COG1206
Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and ...
 6-435 0e+00

Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and biogenesis]; Folate-dependent tRNA-U54 methylase TrmFO/GidA is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440819  Cd Length: 436  Bit Score: 927.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVLKEEMRKLNSVIIHSAD 85
Cdd:COG1206    4 VTVIGGGLAGSEAAWQLAERGVPVRLYEMRPVKMTPAHKTDGFAELVCSNSLRSDDLTNAVGLLKEEMRRLGSLIMAAAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  86 SSAVPAGGALAVDRHDFAARVTEQVKNHPNVTVINEEVTDIPE-GPTVIATGPLTSEALSAKLKELSGEDYLYFYDAAAP 164
Cdd:COG1206   84 AHRVPAGGALAVDREGFSAAVTEKLENHPNITVVREEVTEIPEdGPVIIATGPLTSDALAEAIQELTGEEYLYFYDAIAP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 165 ILEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALTSAETVPLKEFEKEIFFEGCMPIEVMANRGKKTMLFGP 244
Cdd:COG1206  164 IVDADSIDMDKAFRASRYDKGEADYLNCPMTKEEYEAFYEALLAAEKVELKDFEKEKYFEGCLPIEVMARRGRDTLRFGP 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 245 MKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKVLRA 324
Cdd:COG1206  244 MKPVGLTDPRTGKRPYAVVQLRQENAEGTLYNLVGFQTKLKWGEQKRVFRMIPGLENAEFVRYGVMHRNTFINSPKLLDP 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 325 TYQFKNRDDLFFAGQMTGVEGYVESAASGLVAGINAARLVAGEDPIEFPHETAIGSMARYITTANPKSFQPMNANFGLFP 404
Cdd:COG1206  324 TLQLKARPNLFFAGQITGVEGYVESAASGLLAGINAARLLLGKEPVPPPPTTALGALLNYITGADPKDFQPMNVNFGLLP 403

                        410       420       430
                 ....*....|....*....|....*....|.
gi 850308844 405 DLPEKIRGKKERNEKHAERALGTIQNFVKNL 435
Cdd:COG1206  404 PLEKRIRDKKERKEAYAERALEDLEAWLAEL 434
PRK05335 PRK05335
tRNA (uracil-5-)-methyltransferase Gid; Reviewed
 6-435 0e+00

tRNA (uracil-5-)-methyltransferase Gid; Reviewed


Pssm-ID: 235416  Cd Length: 436  Bit Score: 905.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVLKEEMRKLNSVIIHSAD 85
Cdd:PRK05335   5 VNVIGAGLAGSEAAWQLAKRGVPVELYEMRPVKKTPAHHTDGFAELVCSNSFRSDSLTNAVGLLKEEMRRLGSLIMEAAD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  86 SSAVPAGGALAVDRHDFAARVTEQVKNHPNVTVINEEVTDIPEGPTVIATGPLTSEALSAKLKELSGEDYLYFYDAAAPI 165
Cdd:PRK05335  85 AHRVPAGGALAVDREGFSEYVTEALENHPLITVIREEVTEIPEDITIIATGPLTSDALAEAIKALTGEDYLYFFDAAAPI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 166 LEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALTSAETVPLKEFEKEIFFEGCMPIEVMANRGKKTMLFGPM 245
Cdd:PRK05335 165 VDKDSIDMDKVYLASRYDKGEADYLNCPMTKEEYEAFYEALIAAEKAELKDFEKEKYFEGCMPIEVMAERGRETLRFGPM 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 246 KPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKVLRAT 325
Cdd:PRK05335 245 KPVGLTDPRTGKRPYAVVQLRQDNAAGTLYNIVGFQTKLKWGEQKRVFRMIPGLENAEFVRYGVMHRNTFINSPKLLDPT 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 326 YQFKNRDDLFFAGQMTGVEGYVESAASGLVAGINAARLVAGEDPIEFPHETAIGSMARYITTANPKSFQPMNANFGLFPD 405
Cdd:PRK05335 325 LQLKKRPNLFFAGQITGVEGYVESAASGLLAGINAARLALGKEPVIPPPTTALGALLNYITGANPKHFQPMNANFGLFPP 404

                        410       420       430
                 ....*....|....*....|....*....|..
gi 850308844 406 LPEKIRG--KKERNEKHAERALGTIQNFVKNL 435
Cdd:PRK05335 405 LGKRIRGedKKERKEAYAERALADLKEWLKEL 436
gid_trmFO TIGR00137
tRNA:m(5)U-54 methyltransferase; This model represents an orthologous set of proteins present ...
 4-433 0e+00

tRNA:m(5)U-54 methyltransferase; This model represents an orthologous set of proteins present in relatively few bacteria but very tightly conserved where it occurs. It is closely related to gidA (glucose-inhibited division protein A), which appears to be present in all complete eubacterial genomes so far and in Saccharomyces cerevisiae. It was designated gid but is now recognized as a tRNA:m(5)U-54 methyltransferase and is now designated trmFO. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129243  Cd Length: 433  Bit Score: 764.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844    4 TAVNVIGAGLAGSEAAWQLASRGIKVNLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVLKEEMRKLNSVIIHS 83
Cdd:TIGR00137   1 TPVHVIGGGLAGSEAAWQLAQAGVPVILYEMRPEKLTPAHHTEDLAELVCSNSLGAKALDRAAGLLKTEMRQLSSLIITA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   84 ADSSAVPAGGALAVDRHDFAARVTEQVKNHPNVTVINEEVTDIPE-GPTVIATGPLTSEALSAKLKELSGEDYLYFYDAA 162
Cdd:TIGR00137  81 ADRHAVPAGGALAVDRGIFSRSLTEQVASHPNVTLIREEVTEIPEeGITVIATGPLTSPALSEDLKELTGMDYLYFYDAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  163 APILEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALTSAETVPLKEFEKEIFFEGCMPIEVMANRGKKTMLF 242
Cdd:TIGR00137 161 APIVEGDSIDKEKAFFASRYDKGEAAYLNCPFTEEEYFNFWEALCEAEQVPLKDFEKAKFFEGCLPIEEMAQRGEKTMLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  243 GPMKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKVL 322
Cdd:TIGR00137 241 GPMKPVGLFDPRTGKKPYAVVQLRQEDKAGTLWNMVGFQTNLRWGEQKRVFRLIPGLENAEFVRMGVMHRNTFINSPQLL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  323 RATYQFKNRDDLFFAGQMTGVEGYVESAASGLVAGINAARLVAGEDPIEFPHETAIGSMARYITTANPKSFQPMNANFGL 402
Cdd:TIGR00137 321 TASLHFKDRQTLFFAGQLTGVEGYVASTAGGWLAGINAARLALGEPLLTLPAETMMGALFNYISTASPKHFQPMNPNFGL 400

                         410       420       430
                  ....*....|....*....|....*....|.
gi 850308844  403 FPDLPEKIRGKKERNEKHAERALGTIQNFVK 433
Cdd:TIGR00137 401 LPELPQKIRNKKERYEQYADRALETLTTWQK 431
GIDA pfam01134
Glucose inhibited division protein A;
6-368 1.92e-153

Glucose inhibited division protein A;


Pssm-ID: 250388 [Multi-domain]  Cd Length: 391  Bit Score: 440.06  E-value: 1.92e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844    6 VNVIGAGLAGSEAAWQLASRGIKVNLYemrpvrqtpAHHTDKFAELVCSNSLRANtltnAVGVLKEEMRKLNSVIIHSAD 85
Cdd:pfam01134   2 VIVIGGGHAGCEAALAAARMGAKVLLI---------THNTDTIAELSCNPSIGGI----AKGHLVREIDALGGLMGKAAD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   86 SSAV----------PAGGAL--AVDRHDFAARVTEQVKNHPNVTVINEEVTDI------------------PEGPTVIAT 135
Cdd:pfam01134  69 KTGIqfrmlntskgPAVRALraQVDRDLYSKEMTETLENHPNLTLIQGEVTDLipengkvkgvvtedgeeyKAKAVVLAT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  136 GP--------------------LTSEALSAKLKELsGEDYLYFYDAAAPILEKDSIDMNKVYLKSRYDKG-EAAYLNCPM 194
Cdd:pfam01134 149 GTflngkihiglkcypagrlgeLTSEGLSESLKEL-GFELGRFKTGTPPRIDKDSIDFSKLEEQPGDKPGpPFSYLNCPM 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  195 TEEEFDRFYEALTSAETVPLKEFEKE-IFFEGCmpIEVMANRGKKTMLFgpmKPVGLEDpktgkRPYAVVQLRQDDAAGT 273
Cdd:pfam01134 228 NKEQYPCFLTYTNEATHEIIRDNLHRsPMFEGC--IEGIGPRYCPSIED---KPVRFAD-----KPYHQVFLEPEGLDTD 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  274 LYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKvLRATYQFKNRDDLFFAGQMTGVEGYVESAASG 353
Cdd:pfam01134 298 EYYLVGFSTSLPEDVQKRVLRTIPGLENAEIVRPGYAIEYDYIDPPQ-LLPTLETKKIPGLFFAGQINGTEGYEEAAAQG 376

                         410
                  ....*....|....*
gi 850308844  354 LVAGINAARLVAGED 368
Cdd:pfam01134 377 LLAGINAARKALGKE 391
 
Name Accession Description Interval E-value
TrmFO COG1206
Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and ...
 6-435 0e+00

Folate-dependent tRNA-U54 methylase TrmFO/GidA [Translation, ribosomal structure and biogenesis]; Folate-dependent tRNA-U54 methylase TrmFO/GidA is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440819  Cd Length: 436  Bit Score: 927.93  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVLKEEMRKLNSVIIHSAD 85
Cdd:COG1206    4 VTVIGGGLAGSEAAWQLAERGVPVRLYEMRPVKMTPAHKTDGFAELVCSNSLRSDDLTNAVGLLKEEMRRLGSLIMAAAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  86 SSAVPAGGALAVDRHDFAARVTEQVKNHPNVTVINEEVTDIPE-GPTVIATGPLTSEALSAKLKELSGEDYLYFYDAAAP 164
Cdd:COG1206   84 AHRVPAGGALAVDREGFSAAVTEKLENHPNITVVREEVTEIPEdGPVIIATGPLTSDALAEAIQELTGEEYLYFYDAIAP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 165 ILEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALTSAETVPLKEFEKEIFFEGCMPIEVMANRGKKTMLFGP 244
Cdd:COG1206  164 IVDADSIDMDKAFRASRYDKGEADYLNCPMTKEEYEAFYEALLAAEKVELKDFEKEKYFEGCLPIEVMARRGRDTLRFGP 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 245 MKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKVLRA 324
Cdd:COG1206  244 MKPVGLTDPRTGKRPYAVVQLRQENAEGTLYNLVGFQTKLKWGEQKRVFRMIPGLENAEFVRYGVMHRNTFINSPKLLDP 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 325 TYQFKNRDDLFFAGQMTGVEGYVESAASGLVAGINAARLVAGEDPIEFPHETAIGSMARYITTANPKSFQPMNANFGLFP 404
Cdd:COG1206  324 TLQLKARPNLFFAGQITGVEGYVESAASGLLAGINAARLLLGKEPVPPPPTTALGALLNYITGADPKDFQPMNVNFGLLP 403

                        410       420       430
                 ....*....|....*....|....*....|.
gi 850308844 405 DLPEKIRGKKERNEKHAERALGTIQNFVKNL 435
Cdd:COG1206  404 PLEKRIRDKKERKEAYAERALEDLEAWLAEL 434
PRK05335 PRK05335
tRNA (uracil-5-)-methyltransferase Gid; Reviewed
 6-435 0e+00

tRNA (uracil-5-)-methyltransferase Gid; Reviewed


Pssm-ID: 235416  Cd Length: 436  Bit Score: 905.67  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVLKEEMRKLNSVIIHSAD 85
Cdd:PRK05335   5 VNVIGAGLAGSEAAWQLAKRGVPVELYEMRPVKKTPAHHTDGFAELVCSNSFRSDSLTNAVGLLKEEMRRLGSLIMEAAD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  86 SSAVPAGGALAVDRHDFAARVTEQVKNHPNVTVINEEVTDIPEGPTVIATGPLTSEALSAKLKELSGEDYLYFYDAAAPI 165
Cdd:PRK05335  85 AHRVPAGGALAVDREGFSEYVTEALENHPLITVIREEVTEIPEDITIIATGPLTSDALAEAIKALTGEDYLYFFDAAAPI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 166 LEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALTSAETVPLKEFEKEIFFEGCMPIEVMANRGKKTMLFGPM 245
Cdd:PRK05335 165 VDKDSIDMDKVYLASRYDKGEADYLNCPMTKEEYEAFYEALIAAEKAELKDFEKEKYFEGCMPIEVMAERGRETLRFGPM 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 246 KPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKVLRAT 325
Cdd:PRK05335 245 KPVGLTDPRTGKRPYAVVQLRQDNAAGTLYNIVGFQTKLKWGEQKRVFRMIPGLENAEFVRYGVMHRNTFINSPKLLDPT 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 326 YQFKNRDDLFFAGQMTGVEGYVESAASGLVAGINAARLVAGEDPIEFPHETAIGSMARYITTANPKSFQPMNANFGLFPD 405
Cdd:PRK05335 325 LQLKKRPNLFFAGQITGVEGYVESAASGLLAGINAARLALGKEPVIPPPTTALGALLNYITGANPKHFQPMNANFGLFPP 404

                        410       420       430
                 ....*....|....*....|....*....|..
gi 850308844 406 LPEKIRG--KKERNEKHAERALGTIQNFVKNL 435
Cdd:PRK05335 405 LGKRIRGedKKERKEAYAERALADLKEWLKEL 436
gid_trmFO TIGR00137
tRNA:m(5)U-54 methyltransferase; This model represents an orthologous set of proteins present ...
 4-433 0e+00

tRNA:m(5)U-54 methyltransferase; This model represents an orthologous set of proteins present in relatively few bacteria but very tightly conserved where it occurs. It is closely related to gidA (glucose-inhibited division protein A), which appears to be present in all complete eubacterial genomes so far and in Saccharomyces cerevisiae. It was designated gid but is now recognized as a tRNA:m(5)U-54 methyltransferase and is now designated trmFO. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129243  Cd Length: 433  Bit Score: 764.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844    4 TAVNVIGAGLAGSEAAWQLASRGIKVNLYEMRPVRQTPAHHTDKFAELVCSNSLRANTLTNAVGVLKEEMRKLNSVIIHS 83
Cdd:TIGR00137   1 TPVHVIGGGLAGSEAAWQLAQAGVPVILYEMRPEKLTPAHHTEDLAELVCSNSLGAKALDRAAGLLKTEMRQLSSLIITA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   84 ADSSAVPAGGALAVDRHDFAARVTEQVKNHPNVTVINEEVTDIPE-GPTVIATGPLTSEALSAKLKELSGEDYLYFYDAA 162
Cdd:TIGR00137  81 ADRHAVPAGGALAVDRGIFSRSLTEQVASHPNVTLIREEVTEIPEeGITVIATGPLTSPALSEDLKELTGMDYLYFYDAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  163 APILEKDSIDMNKVYLKSRYDKGEAAYLNCPMTEEEFDRFYEALTSAETVPLKEFEKEIFFEGCMPIEVMANRGKKTMLF 242
Cdd:TIGR00137 161 APIVEGDSIDKEKAFFASRYDKGEAAYLNCPFTEEEYFNFWEALCEAEQVPLKDFEKAKFFEGCLPIEEMAQRGEKTMLF 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  243 GPMKPVGLEDPKTGKRPYAVVQLRQDDAAGTLYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKVL 322
Cdd:TIGR00137 241 GPMKPVGLFDPRTGKKPYAVVQLRQEDKAGTLWNMVGFQTNLRWGEQKRVFRLIPGLENAEFVRMGVMHRNTFINSPQLL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  323 RATYQFKNRDDLFFAGQMTGVEGYVESAASGLVAGINAARLVAGEDPIEFPHETAIGSMARYITTANPKSFQPMNANFGL 402
Cdd:TIGR00137 321 TASLHFKDRQTLFFAGQLTGVEGYVASTAGGWLAGINAARLALGEPLLTLPAETMMGALFNYISTASPKHFQPMNPNFGL 400

                         410       420       430
                  ....*....|....*....|....*....|.
gi 850308844  403 FPDLPEKIRGKKERNEKHAERALGTIQNFVK 433
Cdd:TIGR00137 401 LPELPQKIRNKKERYEQYADRALETLTTWQK 431
GIDA pfam01134
Glucose inhibited division protein A;
6-368 1.92e-153

Glucose inhibited division protein A;


Pssm-ID: 250388 [Multi-domain]  Cd Length: 391  Bit Score: 440.06  E-value: 1.92e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844    6 VNVIGAGLAGSEAAWQLASRGIKVNLYemrpvrqtpAHHTDKFAELVCSNSLRANtltnAVGVLKEEMRKLNSVIIHSAD 85
Cdd:pfam01134   2 VIVIGGGHAGCEAALAAARMGAKVLLI---------THNTDTIAELSCNPSIGGI----AKGHLVREIDALGGLMGKAAD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   86 SSAV----------PAGGAL--AVDRHDFAARVTEQVKNHPNVTVINEEVTDI------------------PEGPTVIAT 135
Cdd:pfam01134  69 KTGIqfrmlntskgPAVRALraQVDRDLYSKEMTETLENHPNLTLIQGEVTDLipengkvkgvvtedgeeyKAKAVVLAT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  136 GP--------------------LTSEALSAKLKELsGEDYLYFYDAAAPILEKDSIDMNKVYLKSRYDKG-EAAYLNCPM 194
Cdd:pfam01134 149 GTflngkihiglkcypagrlgeLTSEGLSESLKEL-GFELGRFKTGTPPRIDKDSIDFSKLEEQPGDKPGpPFSYLNCPM 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  195 TEEEFDRFYEALTSAETVPLKEFEKE-IFFEGCmpIEVMANRGKKTMLFgpmKPVGLEDpktgkRPYAVVQLRQDDAAGT 273
Cdd:pfam01134 228 NKEQYPCFLTYTNEATHEIIRDNLHRsPMFEGC--IEGIGPRYCPSIED---KPVRFAD-----KPYHQVFLEPEGLDTD 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  274 LYNIVGFQTHLKWGPQKEVIRLIPGLENAEIVRYGVMHRNTFINSPKvLRATYQFKNRDDLFFAGQMTGVEGYVESAASG 353
Cdd:pfam01134 298 EYYLVGFSTSLPEDVQKRVLRTIPGLENAEIVRPGYAIEYDYIDPPQ-LLPTLETKKIPGLFFAGQINGTEGYEEAAAQG 376

                         410
                  ....*....|....*
gi 850308844  354 LVAGINAARLVAGED 368
Cdd:pfam01134 377 LLAGINAARKALGKE 391
MnmG COG0445
tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA [Translation, ribosomal ...
 289-370 1.40e-19

tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA [Translation, ribosomal structure and biogenesis]; tRNA U34 5-carboxymethylaminomethyl modifying enzyme MnmG/GidA is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440214 [Multi-domain]  Cd Length: 626  Bit Score: 91.22  E-value: 1.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844 289 QKEVIRLIPGLENAEIVRYGvmhrntFINsPKVLRATYQFKNRDDLFFAGQMTGVEGYVESAASGLVAGINAARLVAGED 368
Cdd:COG0445  320 QLAMLRSIPGLENAEILRPGyaieydYVD-PTQLKPTLETKKIEGLFFAGQINGTTGYEEAAAQGLMAGINAALKAQGKE 398


                 ..
gi 850308844 369 PI 370
Cdd:COG0445  399 PF 400
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-36 4.39e-06

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 48.70  E-value: 4.39e-06
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 850308844   1 MKDTAVNVIGAGLAGSEAAWQLASRGIKVNLYEMRP 36
Cdd:COG3349    1 MMPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARP 36
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
8-36 7.84e-06

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 43.29  E-value: 7.84e-06
                          10        20
                  ....*....|....*....|....*....
gi 850308844    8 VIGAGLAGSEAAWQLASRGIKVNLYEMRP 36
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRD 29
FixC COG0644
Dehydrogenase (flavoprotein) [Energy production and conversion];
11-147 2.59e-05

Dehydrogenase (flavoprotein) [Energy production and conversion];


Pssm-ID: 440409 [Multi-domain]  Cd Length: 281  Bit Score: 45.73  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  11 AGLAGSEAAWQLASRGIKVNLYEMRPVrqtPAHHTdkFAELVCSNSLRantLTNAVGVLKEEMRKLNSVIIHSADSSAV- 89
Cdd:COG0644    1 AGPAGSAAARRLARAGLSVLLLEKGSF---PGDKI--CGGGLLPRALE---ELEPLGLDEPLERPVRGARFYSPGGKSVe 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 850308844  90 ---PAGGALAVDRHDFAARVTEQVKNHpNVTVI-NEEVTDI--PEGPTVIATGplTSEALSAKL 147
Cdd:COG0644   73 lppGRGGGYVVDRARFDRWLAEQAEEA-GAEVRtGTRVTDVlrDDGRVVVRTG--DGEEIRADY 133
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-147 5.09e-05

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 44.93  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   1 MKDTAVNVIGAGLAGSEAAWQLASRGIKVNLYEMRP-VRQTPAHHTdkfaelvcsnsLRANTLT--NAVGVLkEEMRKLN 77
Cdd:COG0654    1 MMRTDVLIVGGGPAGLALALALARAGIRVTVVERAPpPRPDGRGIA-----------LSPRSLEllRRLGLW-DRLLARG 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844  78 SVI-------------IHSADSSAVPAGGALAVDRHDFAARVTEQVKNHpNVTVI-NEEVTDI---PEGPTV-IATGplt 139
Cdd:COG0654   69 APIrgirvrdgsdgrvLARFDAAETGLPAGLVVPRADLERALLEAARAL-GVELRfGTEVTGLeqdADGVTVtLADG--- 144


                 ....*...
gi 850308844 140 sEALSAKL 147
Cdd:COG0654  145 -RTLRADL 151
PRK07208 PRK07208
hypothetical protein; Provisional
 1-37 2.46e-04

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 43.34  E-value: 2.46e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 850308844   1 MKDTAVnVIGAGLAGSEAAWQLASRGIKVNLYEMRPV 37
Cdd:PRK07208   3 NKKSVV-IIGAGPAGLTAAYELLKRGYPVTVLEADPV 38
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
8-45 6.49e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 41.81  E-value: 6.49e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 850308844   8 VIGAGLAGSEAAWQLASRGIKVNLYEmrpvRQTPAHHT 45
Cdd:COG0665    7 VIGGGIAGLSTAYHLARRGLDVTVLE----RGRPGSGA 40
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 4-36 1.28e-03

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 40.56  E-value: 1.28e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 850308844   4 TAVnVIGAGLAGSEAAWQLASRGIKVNLYEMRP 36
Cdd:COG0446  126 RAV-VIGGGPIGLELAEALRKRGLKVTLVERAP 157
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 6-36 2.12e-03

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 40.15  E-value: 2.12e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 850308844   6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRP 36
Cdd:PRK12810 146 VAVVGSGPAGLAAADQLARAGHKVTVFERAD 176
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 8-45 2.60e-03

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 39.69  E-value: 2.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 850308844    8 VIGAGLAGSEAAWQLASRGIKVNLYEMRPVrqtPAHHT 45
Cdd:pfam01266   4 VIGGGIVGLSTAYELARRGLSVTLLERGDD---PGSGA 38
PLN02487 PLN02487
zeta-carotene desaturase
 6-36 3.95e-03

zeta-carotene desaturase


Pssm-ID: 215268 [Multi-domain]  Cd Length: 569  Bit Score: 39.40  E-value: 3.95e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 850308844   6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRP 36
Cdd:PLN02487  78 VAIIGAGLAGMSTAVELLDQGHEVDIYESRP 108
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 6-202 3.98e-03

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 38.84  E-value: 3.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844    6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRpvrqtpahhtDKFAELVCSNSLRANTLTNAVGVLKEEMRKLNSVIIHSAD 85
Cdd:TIGR02032   3 VVVVGAGPAGASAAYRLADKGLRVLLLEKK----------SFPRYKPCGGALSPRALEELDLPGELIVNLVRGARFFSPN 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 850308844   86 SSAV----PAGGALAVDRHDFAARVTEQVKNHPNVTVINEEVTDIPEGPTVIATGPLTSEalsaklKELSGeDYLYFYDA 161
Cdd:TIGR02032  73 GDSVeipiETELAYVIDRDAFDEQLAERAQEAGAELRLGTRVLDVEIHDDRVVVIVRGSE------GTVTA-KIVIGADG 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 850308844  162 AAPILeKDSIDMNkvylKSRYDKGEAAYLNCPMTEEEFDRF 202
Cdd:TIGR02032 146 SRSIV-AKKLGLK----KEPREYGVAARAEVEMPDEEVDED 181
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 8-33 4.28e-03

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 39.44  E-value: 4.28e-03
                         10        20
                 ....*....|....*....|....*.
gi 850308844   8 VIGAGLAGSEAAWQLASRGIKVNLYE 33
Cdd:PRK01747 265 IIGGGIAGAALALALARRGWQVTLYE 290
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 6-36 4.56e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 39.47  E-value: 4.56e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 850308844   6 VNVIGAGLAGSEAAWQLASRGIKVNLYEMRP 36
Cdd:PRK12771 140 VAVIGGGPAGLSAAYHLRRMGHAVTIFEAGP 170
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
8-35 4.65e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 39.13  E-value: 4.65e-03
                         10        20
                 ....*....|....*....|....*...
gi 850308844   8 VIGAGLAGSEAAWQLASRGIKVNLYEMR 35
Cdd:COG1231   12 IVGAGLAGLAAARELRKAGLDVTVLEAR 39
PRK07233 PRK07233
hypothetical protein; Provisional
 8-37 7.45e-03

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 38.33  E-value: 7.45e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 850308844   8 VIGAGLAGSEAAWQLASRGIKVNLYEMRPV 37
Cdd:PRK07233   4 IVGGGIAGLAAAYRLAKRGHEVTVFEADDQ 33
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
8-36 7.46e-03

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 38.58  E-value: 7.46e-03
                         10        20
                 ....*....|....*....|....*....
gi 850308844   8 VIGAGLAGSEAAWQLASRGIKVNLYEMRP 36
Cdd:COG1251  147 VIGGGLIGLEAAAALRKRGLEVTVVERAP 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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