|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
25-449 |
9.11e-115 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 343.82 E-value: 9.11e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQLWIAVPI 104
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 105 AAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVSVGLPWLV 184
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 185 KALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMLGKF--TLREHIAGLRKNDQLLLMLAMSFLLINVFNIR 262
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 263 GGGYMYFITYVLGGsTGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPSWqtLWLAV 342
Cdd:cd17332 241 NTVLVYYFKYVLGG-RAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLV--LILVL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 343 ILGNGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASNQTPSSLSG 422
Cdd:cd17332 318 AVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNG 397
|
410 420
....*....|....*....|....*..
gi 852142439 423 ITAMETLLPALFHLLLAFAIRACKLNN 449
Cdd:cd17332 398 IRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-463 |
1.35e-109 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 331.48 E-value: 1.35e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 18 DKLSLREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQ 97
Cdd:COG2211 5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 98 LWIAVPIAAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVS 177
Cdd:COG2211 85 LIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLAS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 178 VGLPWLVKALGqGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMlGKFTLREHIAGLRKNDQLLLMLAMSFLLIN 257
Cdd:COG2211 165 VLPPPLVAAFG-GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-EKVSLKESLKALLKNRPFLLLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 258 VFNIRGGGYMYFITYVLGGSTGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPSWqt 337
Cdd:COG2211 243 ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW-- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 338 LWLAVILGNGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASnQTP 417
Cdd:COG2211 321 LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA-QSP 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 852142439 418 SSLSGITAMETLLPALFHLLLAFAIRACKLNNPMMSRIAADLRARH 463
Cdd:COG2211 400 SALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARR 445
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
15-459 |
3.60e-97 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 299.33 E-value: 3.60e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 15 MQDDKLSLREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFR 94
Cdd:PRK09669 1 MNTSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 95 PWQLWIAVPIAAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGF 174
Cdd:PRK09669 81 PYLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 175 LVSV-GLPwLVKALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMLGKFTLREHIAGLRKNDQLLLMLAMSF 253
Cdd:PRK09669 161 IVSViALP-LVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMFIFNV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 254 LLINVFNIRGGGYMYFITYVLgGSTGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGP 333
Cdd:PRK09669 240 VLLTAVVTRGGATLYYVNYVL-LRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSN 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 334 SWQTLWLAVILgnGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGAS 413
Cdd:PRK09669 319 VWLIFALNILF--NFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAA 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 852142439 414 NQTPSSLSGITAMETLLPALFHLLLAFAIRACKLNNPMMSRIAADL 459
Cdd:PRK09669 397 VQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQEL 442
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
25-462 |
1.42e-93 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 289.92 E-value: 1.42e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQLWIAVPI 104
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 105 AAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVSVGLPWLV 184
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 185 KALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSL---EMLGKFTLREHIAGLRKNDQLLLMLAMSFLLINVFNI 261
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEipkNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 262 RGGGYMYFITYVLGGSTGYtSLFFTMVTFSSILGAAIVNWLSRHVDTVKLyYYTNVVLALLAVGMWFLPTGPSWQTLWLA 341
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELF-SYMGSIAIVAGLIGVLLFPRLVKKFGRKIL-FAGGILLMVLGYLIFFFAGSNLPLILVLI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 342 VILgnGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASnQTPSSLS 421
Cdd:TIGR00792 319 ILA--GFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAA-QSPITLN 395
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 852142439 422 GITAMETLLPALFHLLLAFAI-RACKLNNPMMSRIAADLRAR 462
Cdd:TIGR00792 396 GIKILMFAVPALFLLLAAIIIgRFYKLTEKKHAEIVEELEQR 437
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
27-424 |
7.89e-62 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 207.16 E-value: 7.89e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 27 GYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQLWIAVPIAA 106
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 107 IGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVSVGLPWLVKA 186
Cdd:pfam13347 81 SFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 187 LGQ-GNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEML------GKFTLREHIAGLRKNDQLLLMLAMSFLLINVF 259
Cdd:pfam13347 161 LGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKedtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALAM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 260 NIRGGGYMYFITYVLGGSTGYtSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPSWQTLW 339
Cdd:pfam13347 241 GVLNGLLLYYFRYVLGNGFAA-SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 340 LAVILGNGIILGFTLPLhfSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASNQTPSS 419
Cdd:pfam13347 320 LYIIIGFGYGSSFFLPW--SMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQA 397
|
....*
gi 852142439 420 LSGIT 424
Cdd:pfam13347 398 VTAIR 402
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
25-449 |
9.11e-115 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 343.82 E-value: 9.11e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQLWIAVPI 104
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 105 AAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVSVGLPWLV 184
Cdd:cd17332 81 ALLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 185 KALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMLGKF--TLREHIAGLRKNDQLLLMLAMSFLLINVFNIR 262
Cdd:cd17332 161 AYFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSklPLLKSLKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 263 GGGYMYFITYVLGGsTGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPSWqtLWLAV 342
Cdd:cd17332 241 NTVLVYYFKYVLGG-RAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLV--LILVL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 343 ILGNGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASNQTPSSLSG 422
Cdd:cd17332 318 AVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNG 397
|
410 420
....*....|....*....|....*..
gi 852142439 423 ITAMETLLPALFHLLLAFAIRACKLNN 449
Cdd:cd17332 398 IRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
18-463 |
1.35e-109 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 331.48 E-value: 1.35e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 18 DKLSLREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQ 97
Cdd:COG2211 5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 98 LWIAVPIAAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVS 177
Cdd:COG2211 85 LIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLAS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 178 VGLPWLVKALGqGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMlGKFTLREHIAGLRKNDQLLLMLAMSFLLIN 257
Cdd:COG2211 165 VLPPPLVAAFG-GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-EKVSLKESLKALLKNRPFLLLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 258 VFNIRGGGYMYFITYVLGGSTGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPSWqt 337
Cdd:COG2211 243 ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLW-- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 338 LWLAVILGNGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASnQTP 417
Cdd:COG2211 321 LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA-QSP 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 852142439 418 SSLSGITAMETLLPALFHLLLAFAIRACKLNNPMMSRIAADLRARH 463
Cdd:COG2211 400 SALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARR 445
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
15-459 |
3.60e-97 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 299.33 E-value: 3.60e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 15 MQDDKLSLREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFR 94
Cdd:PRK09669 1 MNTSQLTTKDKIGYGLGDTACNLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 95 PWQLWIAVPIAAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGF 174
Cdd:PRK09669 81 PYLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 175 LVSV-GLPwLVKALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMLGKFTLREHIAGLRKNDQLLLMLAMSF 253
Cdd:PRK09669 161 IVSViALP-LVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMFIFNV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 254 LLINVFNIRGGGYMYFITYVLgGSTGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGP 333
Cdd:PRK09669 240 VLLTAVVTRGGATLYYVNYVL-LRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPPSN 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 334 SWQTLWLAVILgnGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGAS 413
Cdd:PRK09669 319 VWLIFALNILF--NFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGAA 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 852142439 414 NQTPSSLSGITAMETLLPALFHLLLAFAIRACKLNNPMMSRIAADL 459
Cdd:PRK09669 397 VQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDARVEAIAQEL 442
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
25-462 |
1.42e-93 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 289.92 E-value: 1.42e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQLWIAVPI 104
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 105 AAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVSVGLPWLV 184
Cdd:TIGR00792 81 SIVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 185 KALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSL---EMLGKFTLREHIAGLRKNDQLLLMLAMSFLLINVFNI 261
Cdd:TIGR00792 161 SYFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEipkNIEKKLSLKQIFKALFKNDQLLILCLAYLFYNLAFNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 262 RGGGYMYFITYVLGGSTGYtSLFFTMVTFSSILGAAIVNWLSRHVDTVKLyYYTNVVLALLAVGMWFLPTGPSWQTLWLA 341
Cdd:TIGR00792 241 KNGVQVYYFTYVLGDPELF-SYMGSIAIVAGLIGVLLFPRLVKKFGRKIL-FAGGILLMVLGYLIFFFAGSNLPLILVLI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 342 VILgnGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASnQTPSSLS 421
Cdd:TIGR00792 319 ILA--GFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAA-QSPITLN 395
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 852142439 422 GITAMETLLPALFHLLLAFAI-RACKLNNPMMSRIAADLRAR 462
Cdd:TIGR00792 396 GIKILMFAVPALFLLLAAIIIgRFYKLTEKKHAEIVEELEQR 437
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
15-465 |
1.74e-89 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 280.28 E-value: 1.74e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 15 MQDDKLSLREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFR 94
Cdd:PRK11462 1 MKSEVLSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 95 PWQLWIAVPIAAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGF 174
Cdd:PRK11462 81 PWVLFGALPFGIVCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 175 LVSVGLPWLVKALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMlGKFTLREHIAGLRKNDQLLLMLAMSFL 254
Cdd:PRK11462 161 LSTVLMMPLVNLIGGDNKPLGFQGGIAVLSVVAFMMLAFCFFTTKERVEAPP-TTTSMREDLRDIWQNDQWRIVGLLTIF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 255 LINVFNIRGGGYMYFITYVLGGSTGYTSlFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPS 334
Cdd:PRK11462 240 NILAVCVRGGAMMYYVTWILGTPEVFVA-FLTTYCVGNLIGSALAKPLTDWKCKVTIFWWTNALLAVISLAMFFVPMQAS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 335 wqTLWLAVILGNGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASN 414
Cdd:PRK11462 319 --ITMFVFIFVIGVLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKA 396
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 852142439 415 QTPSSLSGITAMETLLPALFHLLLA-FAIRACKLNNPMMSRIAADLR--ARHVQ 465
Cdd:PRK11462 397 QNSATISIIIALFTIVPAICYLLSAiIAKRYYSLTTHNLKTVMEQLAqgKRRCQ 450
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
27-424 |
7.89e-62 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 207.16 E-value: 7.89e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 27 GYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQLWIAVPIAA 106
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 107 IGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVSVGLPWLVKA 186
Cdd:pfam13347 81 SFILLFTPPELGRAPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 187 LGQ-GNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEML------GKFTLREHIAGLRKNDQLLLMLAMSFLLINVF 259
Cdd:pfam13347 161 LGGtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKedtgqkEAGSLLDMLKEVFRNRAFLILLASFLLAALAM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 260 NIRGGGYMYFITYVLGGSTGYtSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPSWQTLW 339
Cdd:pfam13347 241 GVLNGLLLYYFRYVLGNGFAA-SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 340 LAVILGNGIILGFTLPLhfSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASNQTPSS 419
Cdd:pfam13347 320 LYIIIGFGYGSSFFLPW--SMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQA 397
|
....*
gi 852142439 420 LSGIT 424
Cdd:pfam13347 398 VTAIR 402
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
19-455 |
6.72e-50 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 176.83 E-value: 6.72e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 19 KLSLREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQL 98
Cdd:PRK10429 2 SISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 99 WIAVPIAAIGVLTFTVPDAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLV-S 177
Cdd:PRK10429 82 IGTLANSVVLFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGFVTaG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 178 VGLPwLVKALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEML-----GKFTLREHIAGLRKNDQLLLMLAMS 252
Cdd:PRK10429 162 FTLP-FVNYVGGGDRGFGFQMFTLVLIAFFIVSTIITLRNVHEVYSSDNQvsaegSHLTLKDIVALIYKNDQLSCLLGMA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 253 FLLINVFNIRGGGYMYFITYVLGGS---TGYTSLFFTMVTFSSILGAAIVNWLSRhvdtvKLYYYTNVVLALLAVGMWFL 329
Cdd:PRK10429 241 LAYNIASNIINGFAIYYFTYVIGDAdlfPYYLSYAGAANLVTLILFPRLVKSLSR-----RILWAGASIFPVLSCGVLLL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 330 PTGPSWQTLWLAVILGNGIILGFTLPLHFSLMAFSD--DYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVA 407
Cdd:PRK10429 316 MGLAAPHNALLIVIAGILLNIGTALFWVLQVIMVADtvDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIG 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 852142439 408 YQPGASnQTPSSLSGITAMETLLPALFHLLLAFAI-RACKLNNPMMSRI 455
Cdd:PRK10429 396 YVPNVE-QSAQTLLGMQFIMIGLPTLFFMITLVLYfRYYRLNGDFLRRI 443
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
19-423 |
1.20e-49 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 175.36 E-value: 1.20e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 19 KLSLREKIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWQL 98
Cdd:PRK09848 4 QLSWRTIVGYSLGDVANNFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 99 WIAVPIAAIGVLTFTVP-DAGMGVKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLCGVAGFLVS 177
Cdd:PRK09848 84 FGTAPLMIFSVLVFWVPtDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARGIAASLTFVCLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 178 VGLPWLVKALGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSlEMLGKFTLREHIAGLRKNDQLLLMLAMSFL-LI 256
Cdd:PRK09848 164 FLIGPSIKNSSPEEMVSVYHFWTIVLAIAGMVLYFICFKSTRENVV-RIVAQPSLKISLQTLKRNRPLFMLCIGALCvLI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 257 NVFNIRGGGyMYFITYVLGGSTGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTgpsWQ 336
Cdd:PRK09848 243 STFAVSASS-LFYVRYVLNDTGLFTVLVLVQNLVGTVASAPLVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSV---WS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 337 TLWLAVILGNGII-LGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGASnQ 415
Cdd:PRK09848 319 LPVALVALAIASIgQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQV-Q 397
|
....*...
gi 852142439 416 TPSSLSGI 423
Cdd:PRK09848 398 TPEVIMGI 405
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
25-415 |
4.66e-13 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 70.61 E-value: 4.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQ-SRWGRFRPWQLWIAVP 103
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPwTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 104 IAAIGVLTFTVPDAGMGvKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLcGVAGFLVSVGLPwl 183
Cdd:cd17451 81 AVLSYFLIWFVPDFSQG-KVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTV-EVLGTVLGTAIQ-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 184 vkalGQGNTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMLGKFTLREHIAGLRkndqlLLM-------LAMSFLLI 256
Cdd:cd17451 157 ----GQIVGMAAYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLK-----LVMshgpyikLITGFLFT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 257 NV-FNIRGGGYMYFITYVLGGSTGYTSLFFtMVTFSSILGAAIVNW-LSRHVDTVKLYYYTNVVLALLAVgmwfLPTGPS 334
Cdd:cd17451 228 SLaFMLLEGNFALFCTYTLGFRNDFQNILL-VIMLSATLTIPFWQWfLTRFGKKTAVYIGISSAVPFLIL----VVLVES 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 335 WQTLWLAVILGNGIILGFTLPLHFSLMA-FSDDYG-EWKTGVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYVAYQPGA 412
Cdd:cd17451 303 NLIVTYVVSVAAGVSVAAAFLLPWSMLPdVVDDFKlKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRG 382
|
...
gi 852142439 413 SNQ 415
Cdd:cd17451 383 CSQ 385
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
25-415 |
9.32e-12 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 66.73 E-value: 9.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQ-SRWGRFRPWQLwIAVP 103
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQrTGIGRLMPWIV-FSTP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 104 IAAIG-VLTFTVPDAGMGvKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRF------VLCG--VAGF 174
Cdd:cd17392 80 LIILAyFFLWFLPPFTSL-SGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMtvevfgTLMGatIQGQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 175 LVSV-------------GLPWLVKALGQgNTAQGYQYGVGVlcaIAAVMFLCC---FFWVRERVSLEMLGKFTLREHIAG 238
Cdd:cd17392 159 IVGVahrprrqdctatpGTSDHPVTVLP-NTRRAYLIAALV---VVVLYFVCCsilFLGVKEQPDPLSPASGPGLSYLAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 239 LRK--NDQLLLMLAMSFLLINV-FNIRGGGYMYFITYVLGGSTGYTSLFFTMVTfSSILGAAIVNW-LSRHVDTVKLYYY 314
Cdd:cd17392 235 LKLvtGHPPYLKLVIGFLFSSLaFQMEQGNFVLFCTHAAGLGDHFQHLVLAILV-SATLSIPLWQWvLQRRGKKTTSFIG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 315 TNVVLALLAVGMWFLPTGPSwqTLWLAVILGNGIILGFTLPLHFSLMAFSDDYGEWKTGVRSSGMNFAFNLFFIKLAWAS 394
Cdd:cd17392 314 ISAMVPFLILLALVPSNLPV--AYVVAVVSGVSLAALFLLPWSMLPDVVDDFQLKNPHCPGLEPIFYSCYVFFTKLGGGL 391
|
410 420
....*....|....*....|.
gi 852142439 395 SAGIISLVFIYVAYQPGASNQ 415
Cdd:cd17392 392 SLGISTLSLHFSGYKAGACKQ 412
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
25-418 |
2.84e-11 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 65.22 E-value: 2.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 25 KIGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQ-SRWGRFRPWQLWIAVP 103
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKwTKIGRLMPWMLGCTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 104 IAAIGVLTFTVPDAGMGvKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRFVLcGVAGFLVSVGLPWL 183
Cdd:cd17452 81 IVVSYFFLWFVPPFTTG-RFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTV-EVLGTLVGAAVQGQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 184 VkalgqgnTAQGYQYGVGVLCAIAAVMFLCCFFWVRERVSLEMLGKFTLREHIAGLRKNDQL--LLMLAMSFLLINV-FN 260
Cdd:cd17452 159 I-------VASAYMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHgpYLKLTASFLFISAaVQ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 261 IRGGGYMYFITYVLGGSTGYTSLFFTmVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLAlLAVGMWFLPTGPSwqTLWL 340
Cdd:cd17452 232 LEQSNFVLFCTHAVDLHDHFQNLVLT-ILVSAVVSIPFWQWFLQRFGKKAAACGISWMIP-FAIMLVTIPNLIV--AYVV 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 341 AVILGNGIILGFTLPLHFsLMAFSDDYGewKTGVRSSGMN---FAFNLFFIKLAWASSAGIISLVFIYVAYQPGASNQTP 417
Cdd:cd17452 308 AFVSGLSIAASLLLPWSM-LPDVVDDFR--LQNPHGKGLEtifYSSYVFFTKLSAGIALGISTLSLEFAGYETGACKQPE 384
|
.
gi 852142439 418 S 418
Cdd:cd17452 385 S 385
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
17-345 |
5.41e-10 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 60.94 E-value: 5.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 17 DDKLSLREKIGYGLGDAGGTVITCLIMNFL-TFFYTDVFGLTPALVGTLFLAL-----RVFDAISDPIMGVLADRTqsrw 90
Cdd:COG2270 4 APKASRREILAWALYDWANSAFSTVITTFVfPPYFTSVAALGDPAAATALWGYalaiaGLLVALLAPVLGAIADRS---- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 91 GRFRPW-QLWIAVPIAAIGVLTFTVPDAgmgvkIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHS-EVISCQAWRFVL 168
Cdd:COG2270 80 GRKKPFlAFFTLLGVLATAALFFVAPGG-----LWLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEiGRVSGLGWALGY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 169 CG-VAGFLVSVGLPWLVKALGQGNTAQGYQYgVGVLCAIAAVMF-LCCFFWVRERVSLEMLGKFT--------LREHIAG 238
Cdd:COG2270 155 LGgVLLLLINLALFLKPEAFGLPDAGEAVRI-SFLLTALWWLLFaLPLFLFLPERPRPGPAPPRGavragfreLRRTLRE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 239 LRKNDQLLLMLAMSFLLINVFN--IRGGGYmyFITYVLGGSTGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTN 316
Cdd:COG2270 234 LRRYRDLLRFLLAYFFYRDGVQtvIAFAGI--YAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSL 311
|
330 340
....*....|....*....|....*....
gi 852142439 317 VVLALLAVGMWFLPTgpSWQTLWLAVILG 345
Cdd:COG2270 312 VIWIVVCLAAYFLTT--ALAFWILGLLIG 338
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
42-385 |
3.72e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.90 E-value: 3.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 42 IMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRtqsrWGRfRPWQLWIAVPIAAIGVLTFTVPDagmgv 121
Cdd:COG2814 28 IVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR----FGR-RRVLLLGLLLFALGSLLCALAPS----- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 122 kIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSeviscQAWRFVLCGVAGFLVSVGLPWLVKALGQgntAQGYQYGVG 201
Cdd:COG2814 98 -LWLLLAARFLQGLGAGALFPAALALIADLVPPER-----RGRALGLLGAGLGLGPALGPLLGGLLAD---LFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 202 VLCAIAAVMFLCCFFWVRERVSLEmlgKFTLREHIAGLRKNDQLLLMLAMSFLLINVFNIRGGGYMYFITYVLGGSTGYT 281
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAA---RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 282 SLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYytnVVLALLAVGMWFLPTGPSWQTLWLAVILgNGIILGFTLPLHFSLM 361
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLL---IGLLLLALGLLLLALAGSLWLLLLALFL-LGFGFGLLFPLLQALV 321
|
330 340
....*....|....*....|....
gi 852142439 362 afSDDYGEWKTGVRSSGMNFAFNL 385
Cdd:COG2814 322 --AELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
54-405 |
2.89e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 49.55 E-value: 2.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 54 FGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGRFRPWqLWIAVPIAAIGV--------LTFTVPDAGMGVKIAW 125
Cdd:cd17313 29 LGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPF-ILVGAPLAALGLilipnaadIGLALGDGPRTWALVL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 126 AFGTYLLLSVSYTAINVPYCALINTMTTRH--SEVISCQAWRFVLCGVAGFLVsVGLPWLVKALGQGNTAQgyqygVGVL 203
Cdd:cd17313 108 FVLGIVLLDFAMNVCQGPVRALLPDLVPPEqrSKANGIINFMGGLGGVLGYLL-GAILWDHNWFGFALGGN-----LKVP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 204 CAIAAVMFLCC----FFWVRER----VSLEMLGKFTLREHIAGLRKND--------QLLLMLAMSFLLINVF-------- 259
Cdd:cd17313 182 FYIGAIILLVCvlvtLFFVKEPplspEAGEHSENPSLGEVLKSLLKLLkimprsllRLLLVIFFWWIAFFPFelfftdym 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 260 --NIRGGGYMYFITYVLGGSTGYTSLFFtmVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTgpSWQT 337
Cdd:cd17313 262 geEVYHGTSAASSHYGAGVRMGAWGLLI--FSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHN--VTVA 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 852142439 338 LWLAVILGNGIILGFTLPlhFSLMAfsdDYGewKTGVRSSGMNFAFNLFFIKLAW---ASSAGIISLVFIY 405
Cdd:cd17313 338 LVLFALGGIGWATININP--YPLVS---DYH--SESGRGQGTDTGLLNLAISLAQilvSLLAGPIIDVKGY 401
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
50-406 |
5.78e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.11 E-value: 5.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 50 YTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTqsrwgrFRPWQLWIAVPIAAIGVLTFTVPDAgmgvkIAWAFGT 129
Cdd:cd06174 22 LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF------GRRPVLLLGLLLFALGALLFAFAPS-----FWLLLLG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 130 YLLLSVSYTAINVPYCALINTMtTRHSEVISCQAWRFVLCGVAGFLVSVGLPWLVKALGqgntaQGYQYGVGVLCAIAAV 209
Cdd:cd06174 91 RFLLGLGSGLIDPAVLALIADL-FPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-----FGWRAVFLIAAALALL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 210 MFLCCFFWVRE-----RVSLEMLGKFTLREHIAGLRKNDQLLLMLAMSFLLINVFNIRGGGYMYFITYVLGGSTGYTSLF 284
Cdd:cd06174 165 AAILLLLVVPDppesaRAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 285 FTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPSWQTLWLAVIlgnGIILGFTLPLHFSLMAFS 364
Cdd:cd06174 245 LSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLL---GFGLGGLLPLSFALIAEL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 852142439 365 DDygewktgVRSSGMNFAFNLFFIKLAWASSAGIISLVFIYV 406
Cdd:cd06174 322 FP-------PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-385 |
9.29e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 9.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 41 LIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGrfrpwqLWIAVPIAAIGVLTFTvpdagMG 120
Cdd:pfam07690 14 LLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV------LLIGLLLFALGLLLLL-----FA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 121 VKIAWAFGTYLLLSVSYTAINVPYCALINTMTTRhSEVISCQAWRFVLCGVAGFLVSVGLPWLVKALGqgntaqgYQYGV 200
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFG-------WRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 201 GVLCAIAAVMFLCCFFWVRERVSLEMLGKFTLREHIAGLRK---NDQLLLMLAMSFLLINVFNIrGGGYMYFITYVLGGS 277
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKallRDPVLWLLLALLLFGFAFFG-LLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 278 TGYTSLFFTMVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGPSWQTLWLAVILgNGIILGFTLPLH 357
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL-LGFGFGLVFPAL 312
|
330 340
....*....|....*....|....*...
gi 852142439 358 FSLMafSDDYGEWKTGVRSSGMNFAFNL 385
Cdd:pfam07690 313 NALV--SDLAPKEERGTASGLYNTAGSL 338
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
45-177 |
5.21e-04 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 42.24 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 45 FLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRW--GRFRPWQLWIAVPIAAIGVLTFTVPDAGMGVK 122
Cdd:cd17491 21 YLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGCGkyGRRKSWHLIGTICVLLSFPFIFNPCLGCSDST 100
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 852142439 123 IAWAFGTY-----LLLSVSYTAINVPYCALINTMTTRHSEVISCQAWRF---VLCGVAGFLVS 177
Cdd:cd17491 101 SEWAKLVYygpfiIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYaftVIANITVYLIA 163
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-221 |
1.14e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 26 IGYGLGDAGGTVITCLIMNFLTFFYTDVFGLTPALVGTLFLALRVFDAISDPIMGVLADRtqsrWGRFRPWQLWIAVPIA 105
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR----LGRRRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 106 AIGVLTFTVPDAgmgvkIAWAFGTYLLLSVSYTAINVPYCALINTMTTRHSeVISCQAWRFVLCGVAGFLVSVGLPWLVk 185
Cdd:COG2271 259 ALALLLLALLPS-----PALAIALLFLAGFGLGGAFGLLWALAAELFPKKA-RGTASGLVNTFGFLGGALGPLLVGYLL- 331
|
170 180 190
....*....|....*....|....*....|....*.
gi 852142439 186 algqgnTAQGYQYGVGVLCAIAAVMFLCCFFWVRER 221
Cdd:COG2271 332 ------DATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
54-362 |
1.87e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 54 FGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGrfrpwqLWIAVPIAAIGVLTFTVPDAgmgvkIAWAFGTYLLL 133
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERT------LLLALLLLAAGLLLRSLAPS-----VALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 134 SVSYTAINVPYCALINTMTTRHSEVIScqAWRFVLCGVAGFLVSVGLPWLVKALGqgntaqgYQYGVGVLCAIAAVMFLC 213
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFPDRVGLMT--GLYTAAMGLGAALAAGLTVPLAAALG-------WRGALAVWALLALLALLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 214 CFFWVRERVSLEMLGKFTLReHIAGLRKNDQLLLMLAMSFLlinvfnirGGGYMYFITYV------LGGSTGYTSLFFTM 287
Cdd:COG2807 188 WLPLLRRRPAAAAAAPAAAS-LRSLWRSPLAWLLTLFFGLQ--------SLLYYAVVAWLppilrdAGLSAATAGLLLSL 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 852142439 288 VTFSSILGAAIVNWLSRHVDTVKLYYYtnVVLALLAVGMWFLPTGPSWQTLWLAVILgnGIILGFTLPLHFSLMA 362
Cdd:COG2807 259 FQLAGIPGSLLVPLLADRLGDRRPLLL--LLGLLGLAGLLGLLLAPGSLPWLWAVLL--GLGQGGLFPLALTLIG 329
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
52-345 |
2.29e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 52 DVFGLTPALVGTLFLALRVFDAISDPIMGVLADRTQSRWGrfrpwqLWIAVPIAAIGVLTFtvpdaGMGVKIAWAFGTYL 131
Cdd:COG0738 36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRG------LLLGLLLMALGLLLF-----ALAPSYPLLLLALF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 132 LLSVSYTAINVPYCALINTMTTRHSEVI--SCQAWrfvlCGVAGFLVsvglPWLVKALGQGNTAQGYQYGVGVLCAIAAV 209
Cdd:COG0738 105 LLGLGLGLLDVAANPYVAALGPETAASRlnLLHAF----FSLGALLG----PLLGGLLILLGLSLSWHLPYLILAVLLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 852142439 210 MFLCCFFWVRERVSLEMLGKFTLREHIAGLRKNDQLLLMLAMSFLLINVFnirGGGYMYFITY---VLGGSTGYTSLFFT 286
Cdd:COG0738 177 LALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAE---GAIGDWLPLYlkdVLGLSEATAALGLS 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 852142439 287 MVTFSSILGAAIVNWLSRHVDTVKLYYYTNVVLALLAVGMWFLPTGpsWQTLWLAVILG 345
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGP--WLALIGLALVG 310
|
|
| |
