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Conserved domains on  [gi|853686726|ref|WP_048339351|]
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iron ABC transporter permease [Klebsiella aerogenes]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 6-299 5.78e-88

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 265.01  E-value: 5.78e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   6 LWTALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITrFGDVLGP 85
Cdd:COG0609   14 VLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIV-LGGGLSA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  86 LTLPGSAFVGGILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLFWSLGGLGLARWDNLF 165
Cdd:COG0609   93 LGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLMGSLAGASWDDVL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 166 IPLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVR 245
Cdd:COG0609  173 LLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIARLLVGPD 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 853686726 246 HRMAVPMCGLLGAILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRAK 299
Cdd:COG0609  253 HRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 6-299 5.78e-88

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 265.01  E-value: 5.78e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   6 LWTALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITrFGDVLGP 85
Cdd:COG0609   14 VLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIV-LGGGLSA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  86 LTLPGSAFVGGILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLFWSLGGLGLARWDNLF 165
Cdd:COG0609   93 LGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLMGSLAGASWDDVL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 166 IPLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVR 245
Cdd:COG0609  173 LLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIARLLVGPD 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 853686726 246 HRMAVPMCGLLGAILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRAK 299
Cdd:COG0609  253 HRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 17-297 2.38e-69

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 217.39  E-value: 2.38e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   17 EIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITrFGDVLGPLTLPGSAFVGG 96
Cdd:pfam01032  32 SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAIL-LGGSLSLFALPLAAFIGA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   97 ILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLFWSLGGLGLARWDNLFIPLLSLALLSG 176
Cdd:pfam01032 111 LLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQSILFWLMGSLSGANWSDVLILLPLLLIGLI 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  177 FTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRHRMAVPMCGLL 256
Cdd:pfam01032 191 LLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPHIARLLVGANHRRLLPLSALL 270

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 853686726  257 GAILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMR 297
Cdd:pfam01032 271 GALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
F420-0_ABCperm TIGR03869
proposed F420-0 ABC transporter, permease protein; his small clade of ABC-type transporter ...
 9-300 1.83e-51

proposed F420-0 ABC transporter, permease protein; his small clade of ABC-type transporter permease protein components is found as a three gene cassette along with a periplasmic substrate-binding protein (TIGR03868) and an ATPase (TIGR03873). The organisms containing this cassette are all Actinobacteria and all contain numerous genes requiring the coenzyme F420. This model was defined based on five such organisms, four of which are lacking all F420 biosynthetic capability save the final side-chain polyglutamate attachment step (via the gene cofE: TIGR01916). In Jonesia denitrificans DSM 20603 and marine actinobacterium PHSC20C1 this cassette is in an apparent operon with the cofE gene and, in PHSC20C1, also with an F420-dependent glucose-6-phosphate dehydrogenase (TIGR03554). Based on these observations we propose that this permease protein is a component of a F420-0 (that is, F420 lacking only the polyglutamate tail) transporter.


Pssm-ID: 163581  Cd Length: 325  Bit Score: 171.96  E-value: 1.83e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726    9 ALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVItrfgdVLG-PLT 87
Cdd:TIGR03869  35 GFPGVALSRLQDAIVWDLRLPRVLTAAAVGAGLAIAGAVMQSLTRNPLADPYLLGLSSGASLGAVAVL-----VLGvAVL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   88 LPGSAFVGGILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYLVF-SGDQRAAGSLLFWSLGGLGLARWDNLFI 166
Cdd:TIGR03869 110 LPVAAFAGALLALAATLGLARTLGTLTPTRTILAGLAVSQLCAAVTSFVIFwSATGDSYREILSWLMGSLAGATWGSVAI 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  167 PLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRH 246
Cdd:TIGR03869 190 AGGALLVVGLVLLASGRVLDAFAFGDSSAAALGVDVERTRWLLLTLVALLTGALVSVSGAIGFVGLILPHAVRLLTGPRH 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 853686726  247 RMAVPMCGLLGAILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRAKG 300
Cdd:TIGR03869 270 RLLLPVSALAGAVFLVWADTLARTVFAPRELPVGIITALIGAPVFAVLLYRSRS 323
btuC PRK09535
cobalamin ABC transporter permease BtuC;
5-297 9.19e-48

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 163.38  E-value: 9.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   5 VLWTALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITRfgDVLG 84
Cdd:PRK09535  73 LEYASPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVL--PLAV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  85 PLTLPGSAFVGGILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYL-VFSGD--QRAagslLFWSLGGLGLARW 161
Cdd:PRK09535 151 PFGLQAAAFAGALVAAFGVYAIATENGRTPVATLLLAGVAVQTFLGAVISYLlLHSGEslRRA----VYWLMGHLHGSTW 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 162 DNLFIPLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRA 241
Cdd:PRK09535 227 SDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLL 306

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 853686726 242 VGVRHRMAVPMCGLLGAILLTGGDILSRSLIAnqELPIGIITAGLGGAFIVGLLMR 297
Cdd:PRK09535 307 VGPDHRILLPTSALAGASFLVATDTVARSGPA--EVPVGIVTAALGAPFFLYLLRT 360
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 31-295 4.53e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 140.38  E-value: 4.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  31 VLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITrFGDVLGPLTLPGSAFVGGILSALAVMILFRVN 110
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALL-LGIGLSNYALGAFAFAGALAIALLVLLLASRG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 111 QLRRAEqLIICGLAVSFLFSALTSYLVFSGDQRAAgSLLFWSLGGLGLARWDNLFIPLLSLALLSGFTLRRWRALDALLA 190
Cdd:cd06550   80 GLSPSK-LILIGIVLSAFFSAGVILISLLSDDSLQ-DLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTF 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 191 GEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRHRMAVPMCGLLGAILLTGGDILSRS 270
Cdd:cd06550  158 DEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRT 237

                        250       260
                 ....*....|....*....|....*
gi 853686726 271 LIANqELPIGIITAGLGGAFIVGLL 295
Cdd:cd06550  238 LLPS-ELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 6-299 5.78e-88

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 265.01  E-value: 5.78e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   6 LWTALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITrFGDVLGP 85
Cdd:COG0609   14 VLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIV-LGGGLSA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  86 LTLPGSAFVGGILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLFWSLGGLGLARWDNLF 165
Cdd:COG0609   93 LGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWLMGSLAGASWDDVL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 166 IPLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVR 245
Cdd:COG0609  173 LLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPHIARLLVGPD 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 853686726 246 HRMAVPMCGLLGAILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRAK 299
Cdd:COG0609  253 HRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 17-297 2.38e-69

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 217.39  E-value: 2.38e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   17 EIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITrFGDVLGPLTLPGSAFVGG 96
Cdd:pfam01032  32 SLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAALGAVLAIL-LGGSLSLFALPLAAFIGA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   97 ILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLFWSLGGLGLARWDNLFIPLLSLALLSG 176
Cdd:pfam01032 111 LLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQSILFWLMGSLSGANWSDVLILLPLLLIGLI 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  177 FTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRHRMAVPMCGLL 256
Cdd:pfam01032 191 LLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPIGFVGLIVPHIARLLVGANHRRLLPLSALL 270

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 853686726  257 GAILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMR 297
Cdd:pfam01032 271 GALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
F420-0_ABCperm TIGR03869
proposed F420-0 ABC transporter, permease protein; his small clade of ABC-type transporter ...
 9-300 1.83e-51

proposed F420-0 ABC transporter, permease protein; his small clade of ABC-type transporter permease protein components is found as a three gene cassette along with a periplasmic substrate-binding protein (TIGR03868) and an ATPase (TIGR03873). The organisms containing this cassette are all Actinobacteria and all contain numerous genes requiring the coenzyme F420. This model was defined based on five such organisms, four of which are lacking all F420 biosynthetic capability save the final side-chain polyglutamate attachment step (via the gene cofE: TIGR01916). In Jonesia denitrificans DSM 20603 and marine actinobacterium PHSC20C1 this cassette is in an apparent operon with the cofE gene and, in PHSC20C1, also with an F420-dependent glucose-6-phosphate dehydrogenase (TIGR03554). Based on these observations we propose that this permease protein is a component of a F420-0 (that is, F420 lacking only the polyglutamate tail) transporter.


Pssm-ID: 163581  Cd Length: 325  Bit Score: 171.96  E-value: 1.83e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726    9 ALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVItrfgdVLG-PLT 87
Cdd:TIGR03869  35 GFPGVALSRLQDAIVWDLRLPRVLTAAAVGAGLAIAGAVMQSLTRNPLADPYLLGLSSGASLGAVAVL-----VLGvAVL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   88 LPGSAFVGGILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYLVF-SGDQRAAGSLLFWSLGGLGLARWDNLFI 166
Cdd:TIGR03869 110 LPVAAFAGALLALAATLGLARTLGTLTPTRTILAGLAVSQLCAAVTSFVIFwSATGDSYREILSWLMGSLAGATWGSVAI 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  167 PLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRH 246
Cdd:TIGR03869 190 AGGALLVVGLVLLASGRVLDAFAFGDSSAAALGVDVERTRWLLLTLVALLTGALVSVSGAIGFVGLILPHAVRLLTGPRH 269

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 853686726  247 RMAVPMCGLLGAILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRAKG 300
Cdd:TIGR03869 270 RLLLPVSALAGAVFLVWADTLARTVFAPRELPVGIITALIGAPVFAVLLYRSRS 323
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 22-298 5.21e-51

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 171.46  E-value: 5.21e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  22 IVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITRFGdvLGPLTLPGSAFVGGILSAL 101
Cdd:COG4779   68 VVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAGAVAAIVVLG--GSGLAVALGALAGGLATAL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 102 AVMILFRvNQLRRAEQLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLFWSLGGLGLARWDNLFIPLLSLALLSGFTLRR 181
Cdd:COG4779  146 LVYLLAW-RGGVSGYRLILVGIGVSAMLTAVNSYLLTRADLEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALAL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 182 WRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGvRHRMAVPMCGLLGAILL 261
Cdd:COG4779  225 ARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAFVALAAPQIARRLTR-SPGPPLLPSALVGALLL 303

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 853686726 262 TGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRA 298
Cdd:COG4779  304 LAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLLIRE 340
btuC PRK09535
cobalamin ABC transporter permease BtuC;
5-297 9.19e-48

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 163.38  E-value: 9.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   5 VLWTALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITRfgDVLG 84
Cdd:PRK09535  73 LEYASPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVL--PLAV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  85 PLTLPGSAFVGGILSALAVMILFRVNQLRRAEQLIICGLAVSFLFSALTSYL-VFSGD--QRAagslLFWSLGGLGLARW 161
Cdd:PRK09535 151 PFGLQAAAFAGALVAAFGVYAIATENGRTPVATLLLAGVAVQTFLGAVISYLlLHSGEslRRA----VYWLMGHLHGSTW 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 162 DNLFIPLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRA 241
Cdd:PRK09535 227 SDVEVALPVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLL 306

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 853686726 242 VGVRHRMAVPMCGLLGAILLTGGDILSRSLIAnqELPIGIITAGLGGAFIVGLLMR 297
Cdd:PRK09535 307 VGPDHRILLPTSALAGASFLVATDTVARSGPA--EVPVGIVTAALGAPFFLYLLRT 360
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
21-297 3.59e-45

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 161.93  E-value: 3.59e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  21 TIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITRFGdVLGPLTLPGSAFVGGILSA 100
Cdd:PRK10577 391 DALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVP-GAGFGWLLAAALLGALAAL 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 101 LAVMILFRVNQLRrAEQLIICGLAVSFLFSALTSYLVFSGDQRAAgSLLFWSLGGLGLARWDNLFIPLLSLALLSGFTLR 180
Cdd:PRK10577 470 ALILLLARRGGFA-PERLLLTGIALSALFTALIQLLLASGDPRAA-QLLTWLSGSTYGVTWAQALPLLIVAVLLLALALL 547

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 181 RWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRHRMAVPMCGLLGAIL 260
Cdd:PRK10577 548 LRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALL 627

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 853686726 261 LTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMR 297
Cdd:PRK10577 628 MVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRR 664
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 20-299 3.30e-42

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 148.18  E-value: 3.30e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  20 KTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITRFGDVLGPLTLPGSAFVGGILS 99
Cdd:PRK03784  51 ELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCAIAGALLI 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 100 ALAVMILFRVNQLRRAeQLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLFWSLGGLGLARWDNLFIPLLSLALLsGFTL 179
Cdd:PRK03784 131 TLILLRFARRHRLSTS-RLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLMLALLPVL-IWLC 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 180 RRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRHRMAVPMCGLLGAI 259
Cdd:PRK03784 209 CQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGAS 288

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 853686726 260 LLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRAK 299
Cdd:PRK03784 289 LLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSH 328
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 31-295 4.53e-40

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 140.38  E-value: 4.53e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  31 VLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITrFGDVLGPLTLPGSAFVGGILSALAVMILFRVN 110
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALL-LGIGLSNYALGAFAFAGALAIALLVLLLASRG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 111 QLRRAEqLIICGLAVSFLFSALTSYLVFSGDQRAAgSLLFWSLGGLGLARWDNLFIPLLSLALLSGFTLRRWRALDALLA 190
Cdd:cd06550   80 GLSPSK-LILIGIVLSAFFSAGVILISLLSDDSLQ-DLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTF 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 191 GEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRHRMAVPMCGLLGAILLTGGDILSRS 270
Cdd:cd06550  158 DEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRT 237

                        250       260
                 ....*....|....*....|....*
gi 853686726 271 LIANqELPIGIITAGLGGAFIVGLL 295
Cdd:cd06550  238 LLPS-ELPVGPVTALLGAPYFLYLL 261
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
22-299 2.91e-39

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 139.80  E-value: 2.91e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  22 IVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITRFGDvLGPLTLPGSAFVGGILSAL 101
Cdd:PRK09777  46 VLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPS-LPVMWLPLLAFIGGMAGLI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 102 AVMILFRVNQLRRaeqLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLfWSLGGLGLARWDNLFIPLLSLALLSGFTLRR 181
Cdd:PRK09777 125 LLKMLAGTHQPMK---LALTGVALSALWASLTDYLMLSRPQDINNALL-WLTGSLWGRDWSFVKVALPWLILLLPLSLSF 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 182 WRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRHRMAVPMCGLLGAILL 261
Cdd:PRK09777 201 CRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLL 280

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 853686726 262 TGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRAK 299
Cdd:PRK09777 281 LLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
7-298 8.03e-39

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 139.06  E-value: 8.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   7 WTALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVitrfgDVLGPL 86
Cdd:PRK11228  31 LNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALT-----SALSPT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  87 TLPGSAF-----VGGILSALAVMILFRVNQLRRAE-QLIICGLAVSFLFSALTSYLVFSGDQRAAGsLLFWSLGGLGLAR 160
Cdd:PRK11228 106 PFAGYSLafiaaCGGGLSWLLVMTAGGGWRHTHDRnRLILAGIALSALCMALTRITLLLAEDHAYG-IFYWLAGGVSHAR 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 161 WDNLFIPLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARR 240
Cdd:PRK11228 185 WQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPHLARF 264

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 853686726 241 AVGVRHRMAVPMCGLLGAILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMRA 298
Cdd:PRK11228 265 WIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARRR 322
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
6-299 8.19e-35

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 133.04  E-value: 8.19e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726   6 LWTALASAPVAEIVKTIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLViTRFGDVLGP 85
Cdd:PRK10577  41 WLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQLALVLA-TLFAPALLA 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  86 LTLPGSAFVGGILSALAVmilFRVNQLRRAE--QLIICGLAVSFLFSALTSYLVFSGDQRAAGsLLFWSLGGLGLARWDN 163
Cdd:PRK10577 120 LASQLAAFAGGLLAAALV---FALAGGKRLSplRLVLAGMVVSLYLGALTTLLLLFNEQYLQG-LFLWGAGSLAQNDWSG 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 164 LFIPLLSLALLSGFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVG 243
Cdd:PRK10577 196 VQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGA 275

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 853686726 244 VRHRMAVPMCGLLGAILLTGGDILSRSL--IANQELPIGIITAGLGGAFIVGLLMRAK 299
Cdd:PRK10577 276 RRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPLLLWLLPRLR 333
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
22-297 2.39e-30

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 116.73  E-value: 2.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  22 IVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITRFGDVLGPLTLpgSAFVGGILSAL 101
Cdd:PRK10440  54 VVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSGVLVAMVLFGQDLTAIAL--AAMAGGIVTSL 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 102 AVMILFRVNQLrRAEQLIICGLAVSFLFSALTSYLVFSGDQRAAGSLLFWSLGGLGLARWDNLF--IPLLSLALLSGFTL 179
Cdd:PRK10440 132 LVWLLAWRNGI-DTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTWAKTSpsAPIIILMLIAAALL 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 180 -RRWRALDallAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRhRMAVPMCGLLGA 258
Cdd:PRK10440 211 vRRMRLLE---MGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLSGTA-RWGLTQAALCGA 286

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 853686726 259 ILLTGGDILSRSLIANQELPIGIITAGLGGAFIVGLLMR 297
Cdd:PRK10440 287 LLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQ 325
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
21-300 2.54e-26

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 105.94  E-value: 2.54e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726  21 TIVIDLRLPRVLLAALTGAGLAIVGLLLQTTTRNELADPFLFGLSSGASAGAVLVITRFGdVLGPLTLPGSAFVGGILSA 100
Cdd:PRK10441  54 TIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFG-YSSAQEQLAMAFAGALVAS 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 101 LAVMIL-----FRVNQLRraeqLIICGLAVSFLFSALTSYLVFSgDQRAAGSLLFWSLGGLGLARWDNLFIPLLSLALLS 175
Cdd:PRK10441 133 LIVAFTgsqggGQLSPVR----LTLAGVALAAVLEGLTSGIALL-NPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAG 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 853686726 176 GFTLRRWRALDALLAGEQTACSLGVEVERLRSETFLCCALATALLVSITGVIGFVGLMVPYLARRAVGVRHRMAVPMCGL 255
Cdd:PRK10441 208 ATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLL 287

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 853686726 256 LGAILLTGGDILSRSLIANqELPIGIITAGLGGAFIVGLLMRAKG 300
Cdd:PRK10441 288 ATPALLLFADIIGRLLVPG-ELRVSVVSAFIGAPVLIFLVRRKTR 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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