|
Name |
Accession |
Description |
Interval |
E-value |
| spoVD_pbp |
TIGR02214 |
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ... |
11-638 |
0e+00 |
|
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]
Pssm-ID: 131269 [Multi-domain] Cd Length: 636 Bit Score: 1052.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 11 RLIFILISGILIFTIIDIRLGYVQFFLGNMLTDRAKDSWSRNITFEPERGKILDRNGVELATNKSAPTVFVVPRQIEKPA 90
Cdd:TIGR02214 1 RSIHILISFTALFLILILRLFYVQVFRGSFYKEMAEDQWTREIPIEAKRGRILDRNGNELAVSVSVDRVDLDPATIRKNK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 91 ET-----AEKLAAVLGVEKDEIYKRITKKESIVRLDKGGRKISHDKAKEVRGLSLKGVYIAEDSIRYYPFGNFLSHVLGF 165
Cdd:TIGR02214 81 EPkqreiANELARVLEMDKEKVFKRITKKNSPFVSAKLGRKIEKDKAEKVRNLKLNGVSVSPDSKRYYPNGDFLSHVLGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 166 AGSDNQGLMGLEKYYDKELNGDEGHVRFFADAKGQRMPNVGDDFKKPEAGLNLGLTIDARINRIMEREMNIAESTYNPDG 245
Cdd:TIGR02214 161 TNSDGRGLEGLELYYDKELRGLPGVRVAEYDANSLELPYAQHAYVKPVDGHDLVLTIDENIQYIIEREADKALRERKPKG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 246 MIAIAMNPKNGEILGMSSRPSFDPADFQSVSPEVYNRNLPVWSTYEPGSTFKIITLAAALNENLVDlEKDTFYDDGAAEV 325
Cdd:TIGR02214 241 VSIIVMNPKNGEILGMSNRPTYDPNDPRDKSPDTARRNRAVSDAYEPGSTFKIITSSAAMEEGIVK-ESDKFYDDGSATV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 326 GGARLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGQKTGIDLQGEGSGILFNLDKVGPVEQAT 405
Cdd:TIGR02214 320 GGKKIKCWKPGGHGSQTFPEVVQNSCNPGFIELGMRLGAEKLNNYILAFGFGSKTGIDLPGEAAGILVPKKKVGPVDLAT 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 406 TSFGQGVSVTPIQQVAAVAAAVNGGTLYQPYIAKEFIDPKNNQVVSKKTPVEKRKVISKETSEKVRYALENVVAKGSGKG 485
Cdd:TIGR02214 400 ISFGQANTVTPIQLMTAVNAVANGGKLIQPHIMKEISDSQNNAVDQTFEPEVKRQVVSKETTQKLRLALETVVSKGSGKN 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 486 AFIDGYRVGGKTGTAQKVK-DGKYLENNYIVSFIGFAPADDPEIVVYVAVDNPKGVTQFGGVVAAPIVGNILRDALPVMG 564
Cdd:TIGR02214 480 AFIEGYRVGGKTGTAQKVKpNGGYMEGEYIVSFVGFAPADDPAVAVLVVVDNPKGVQQFGGLVAAPVFGSVFNDILNYLG 559
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 872563045 565 VKPRTEQVER-EYKWGDIPTVEVPNLIGMKKKDLQTQLVDLKLDIS--GDGEKVIKQSPEAGAKVKEGSKIRIYFGN 638
Cdd:TIGR02214 560 IKPQMNQGEApAAATNQVEAVAVPNLRGMKVDDAEKTLLHLGLDVAteGFGTRVVNQTPIPGEKVKEGTKVVLYLGE 636
|
|
| FtsI |
COG0768 |
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ... |
1-564 |
0e+00 |
|
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain] Cd Length: 568 Bit Score: 646.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 1 MRVSNVT--VRKRLIFILISGILIFTIIDIRLGYVQFFLGNMLTDRAKDSWSRNITFEPERGKILDRNGVELATNKSAPT 78
Cdd:COG0768 1 MKRKKEKrlFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 79 VFVVPRQIEKPAETAEKLAAVLGVEKDEIYKRITKKESI-VRLdkgGRKISHDKAKEVRGLSLKGVYIAEDSIRYYPFGN 157
Cdd:COG0768 81 LYADPEEVKDPEETAEKLAKLLGLDPEELRKKLKKKSRFpVYL---KRNLSPEEAARIRALKLPGVYVEAEYKRYYPYGE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 158 FLSHVLGFAGS----DNQGLMGLEKYYDKELNGDEGHVRFFADAKGQRMPNVGDDfKKPEAGLNLGLTIDARINRIMERE 233
Cdd:COG0768 158 LAAHVLGYVGEinggDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLGEE-KPPVPGKDLVLTIDSDLQKIAEEA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 234 MNIAESTYNPDGMIAIAMNPKNGEILGMSSRPSFDPADFQSVSPEVYnRNLPVWSTYEPGSTFKIITLAAALNENLVDLE 313
Cdd:COG0768 237 LKKAVEEYKAKSGAVVVMDPKTGEILAMASYPSFDPNLFVGGPDEPL-RNRAVQGTYEPGSTFKPFTAAAALEEGVITPD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 314 kDTFYDDGAAEVGGARLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGQKTGIDLQGEGSGILF 393
Cdd:COG0768 316 -TTFDCPGYYRVGGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGLGQKTGIDLPGEASGLLP 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 394 NLDKVGPVEQATTSFGQGVSVTPIQQVAAVAAAVNGGTLYQPYIAKEFIDPKNNQVvsKKTPVEKRKVISKETSEKVRYA 473
Cdd:COG0768 395 SPKRWYPGETATMSIGQGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVV--KEEPEVLRRVISPETAETVREG 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 474 LENVV--AKGSGKGAFIDGYRVGGKTGTAQKV--KDGKYLENNYIVSFIGFAPADDPEIVVYVAVDNPKGvTQFGGVVAA 549
Cdd:COG0768 473 MEGVVnePGGTARRAAIPGYRVAGKTGTAQVVdiGNGGYYKGRHIASFVGFAPADNPRYAVAVVVENPGG-GAYGGTVAA 551
|
570
....*....|....*
gi 872563045 550 PIVGNILRDALPVMG 564
Cdd:COG0768 552 PVFREIMEAYLRLLG 566
|
|
| Transpeptidase |
pfam00905 |
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ... |
246-556 |
1.57e-91 |
|
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain] Cd Length: 296 Bit Score: 285.08 E-value: 1.57e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 246 MIAIAMNPKNGEILGMSSRPSFDPADFQSvspevYNRNLPVWSTYEPGSTFKIITLAAALNENLVDLEKDTFYDDGAAEv 325
Cdd:pfam00905 1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIG-----PLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWPGKQQ- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 326 GGARLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGQKTGIDLQGEGSGILFNLDkvgpVEQAT 405
Cdd:pfam00905 75 GGKSIGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLTPYW----LEGAT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 406 TSFGQGVSVTPIQQVAAVAAAVNGGTLYQPYIAKEFIDpknnqvvSKKTPVEKRKVISKETSEKVRYALENVVAKGSGKG 485
Cdd:pfam00905 151 ASFGIGLTITPLQQAQAYAAIANGGKLVPPHLVKSIED-------KVDPKVLNKLPISKSTAEKVKDMLRLVVNDGTGTG 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 872563045 486 AF-IDGYRVGGKTGTAQKV--KDGKYLENNYIVSFIGFAPADDPEIVVYVAVDNPKGvtQFGGVVAAPIVGNIL 556
Cdd:pfam00905 224 TAaVPGYKVAGKTGTAQVAgpKGGGYYDGAQIGWFVGYAPADNPKYAFAVLIDDPKR--YYGGKVAAPIFKDIL 295
|
|
| PRK15105 |
PRK15105 |
peptidoglycan synthase FtsI; Provisional |
14-567 |
3.97e-67 |
|
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain] Cd Length: 578 Bit Score: 229.71 E-value: 3.97e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 14 FILISGILIFTIID--IRLGYVQFFLGNMLTdRAKDSWSRNITFEP-ERGKILDRNGVELATNKSAPTVFVVPRQI-EKP 89
Cdd:PRK15105 23 FALLCGCILLALVFllGRVAWLQVINPDMLV-REGDMRSLRVQEVStSRGMITDRSGRPLAVSVPVKAIWADPKEVhDAG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 90 AETAEK----LAAVLGVEKDEIYKRI--TKKESIVRLdkgGRKISHDKAKEVRGLSLKGVYIAEDSIRYYPFGNFLSHVL 163
Cdd:PRK15105 102 GISVDDrwkaLADALNIPLDQLSARInaNPKGRFIYL---ARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 164 GFAGSDNQGLMGLEKYYDKELNGDEGHVRFFADAKGQRMPNVGddFKKPEAGLNLGLTIDARINRIMEREMNIAESTYNP 243
Cdd:PRK15105 179 GFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDIS--STDSQAAHNLALSIDERLQALVYRELNNAVAFNKA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 244 DGMIAIAMNPKNGEILGMSSRPSFDPADFQSVSPEVYnRNLPVWSTYEPGSTFKIITLAAALNENLVdlEKDTFYDDGAA 323
Cdd:PRK15105 257 ESGSAVLVDVNTGEVLAMANSPSYNPNNLSGTPKDAM-RNRAITDVFEPGSTVKPMVVMTALQRGVV--KENSVLNTVPY 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 324 EVGGARLKcwKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGQKTGIDLQGEGSGILFNLDKVGPVEQ 403
Cdd:PRK15105 334 RINGHEIK--DVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIER 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 404 ATTSFGQGVSVTPIQQVAAVAAAVNGGtLYQPY-IAKefIDPknnqvvskktPVEKRKVISKETSEKVRYALENV-VAKG 481
Cdd:PRK15105 412 ATFSFGYGLMVTPLQLARVYATIGSYG-IYRPLsITK--VDP----------PVPGERVFPESIVRTVVHMMESVaLPGG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 482 SGKGAFIDGYRVGGKTGTAQKV-KDGKYLeNNYIVSFIGFAPADDPEIVVYVAVDNPKGVTQFGGVVAAPIVGNILRDAL 560
Cdd:PRK15105 479 GGVKAAIKGYRIAIKTGTAKKVgPDGRYI-NKYIAYTAGVAPASQPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVL 557
|
....*..
gi 872563045 561 PVMGVKP 567
Cdd:PRK15105 558 RTMNIEP 564
|
|
| PASTA |
cd06573 |
PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins ... |
585-636 |
1.66e-20 |
|
PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Pssm-ID: 119325 [Multi-domain] Cd Length: 53 Bit Score: 85.07 E-value: 1.66e-20
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 872563045 585 EVPNLIGMKKKDLQTQLVD-LKLDISGDGEKVIKQSPEAGAKVKEGSKIRIYF 636
Cdd:cd06573 1 EVPDLVGISKKDLEEQLYDlLKLDASGSGNKVVKQSPEAGTKVAEGSTIRIYL 53
|
|
| PASTA |
smart00740 |
PASTA domain; |
582-637 |
2.23e-11 |
|
PASTA domain;
Pssm-ID: 197851 [Multi-domain] Cd Length: 67 Bit Score: 59.63 E-value: 2.23e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 872563045 582 PTVEVPNLIGMKKKDLQTQLVDLKLDI--------SGDGEKVIKQSPEAGAKVKEGSKIRIYFG 637
Cdd:smart00740 3 EKVEVPDVIGKSKEEAKKLLKALGLKVevveeyssDGEEGTVISQSPAAGTTVKPGSKVTLTVS 66
|
|
| PknB_PASTA_kin |
NF033483 |
Stk1 family PASTA domain-containing Ser/Thr kinase; |
582-636 |
3.66e-09 |
|
Stk1 family PASTA domain-containing Ser/Thr kinase;
Pssm-ID: 468045 [Multi-domain] Cd Length: 563 Bit Score: 59.42 E-value: 3.66e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 872563045 582 PTVEVPNLIGMKKKDLQTQLVDLKLDISGDGE---------KVIKQSPEAGAKVKEGSKIRIYF 636
Cdd:NF033483 363 KEVTVPDVVGKTEAEAKEALEKAGLKVGKVEEeysddveegKVISTDPEAGTRVKEGSTVTLVV 426
|
|
| PknB_PASTA_kin |
NF033483 |
Stk1 family PASTA domain-containing Ser/Thr kinase; |
582-635 |
6.68e-07 |
|
Stk1 family PASTA domain-containing Ser/Thr kinase;
Pssm-ID: 468045 [Multi-domain] Cd Length: 563 Bit Score: 52.49 E-value: 6.68e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 872563045 582 PTVEVPNLIGMKKKDLQTQLVDLKLDI-------SGDGEK--VIKQSPEAGAKVKEGSKIRIY 635
Cdd:NF033483 431 EKVKVPDLTGKSLDEAKKALEDAGLKVgtieeeySDDVPKgtVISQDPAAGTEVDKGTTVTLT 493
|
|
| PknB_PASTA_kin |
NF033483 |
Stk1 family PASTA domain-containing Ser/Thr kinase; |
583-635 |
1.25e-06 |
|
Stk1 family PASTA domain-containing Ser/Thr kinase;
Pssm-ID: 468045 [Multi-domain] Cd Length: 563 Bit Score: 51.33 E-value: 1.25e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 872563045 583 TVEVPNLIGMKKKDLQTQLVDLKLDISGDGE---------KVIKQSPEAGAKVKEGSKIRIY 635
Cdd:NF033483 500 PVTVPDVTGMSEEEAKSALESAGLKVGVEEEevssdvpagTVISQSPAAGTEVAKGSTVTLT 561
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| spoVD_pbp |
TIGR02214 |
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ... |
11-638 |
0e+00 |
|
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]
Pssm-ID: 131269 [Multi-domain] Cd Length: 636 Bit Score: 1052.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 11 RLIFILISGILIFTIIDIRLGYVQFFLGNMLTDRAKDSWSRNITFEPERGKILDRNGVELATNKSAPTVFVVPRQIEKPA 90
Cdd:TIGR02214 1 RSIHILISFTALFLILILRLFYVQVFRGSFYKEMAEDQWTREIPIEAKRGRILDRNGNELAVSVSVDRVDLDPATIRKNK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 91 ET-----AEKLAAVLGVEKDEIYKRITKKESIVRLDKGGRKISHDKAKEVRGLSLKGVYIAEDSIRYYPFGNFLSHVLGF 165
Cdd:TIGR02214 81 EPkqreiANELARVLEMDKEKVFKRITKKNSPFVSAKLGRKIEKDKAEKVRNLKLNGVSVSPDSKRYYPNGDFLSHVLGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 166 AGSDNQGLMGLEKYYDKELNGDEGHVRFFADAKGQRMPNVGDDFKKPEAGLNLGLTIDARINRIMEREMNIAESTYNPDG 245
Cdd:TIGR02214 161 TNSDGRGLEGLELYYDKELRGLPGVRVAEYDANSLELPYAQHAYVKPVDGHDLVLTIDENIQYIIEREADKALRERKPKG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 246 MIAIAMNPKNGEILGMSSRPSFDPADFQSVSPEVYNRNLPVWSTYEPGSTFKIITLAAALNENLVDlEKDTFYDDGAAEV 325
Cdd:TIGR02214 241 VSIIVMNPKNGEILGMSNRPTYDPNDPRDKSPDTARRNRAVSDAYEPGSTFKIITSSAAMEEGIVK-ESDKFYDDGSATV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 326 GGARLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGQKTGIDLQGEGSGILFNLDKVGPVEQAT 405
Cdd:TIGR02214 320 GGKKIKCWKPGGHGSQTFPEVVQNSCNPGFIELGMRLGAEKLNNYILAFGFGSKTGIDLPGEAAGILVPKKKVGPVDLAT 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 406 TSFGQGVSVTPIQQVAAVAAAVNGGTLYQPYIAKEFIDPKNNQVVSKKTPVEKRKVISKETSEKVRYALENVVAKGSGKG 485
Cdd:TIGR02214 400 ISFGQANTVTPIQLMTAVNAVANGGKLIQPHIMKEISDSQNNAVDQTFEPEVKRQVVSKETTQKLRLALETVVSKGSGKN 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 486 AFIDGYRVGGKTGTAQKVK-DGKYLENNYIVSFIGFAPADDPEIVVYVAVDNPKGVTQFGGVVAAPIVGNILRDALPVMG 564
Cdd:TIGR02214 480 AFIEGYRVGGKTGTAQKVKpNGGYMEGEYIVSFVGFAPADDPAVAVLVVVDNPKGVQQFGGLVAAPVFGSVFNDILNYLG 559
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 872563045 565 VKPRTEQVER-EYKWGDIPTVEVPNLIGMKKKDLQTQLVDLKLDIS--GDGEKVIKQSPEAGAKVKEGSKIRIYFGN 638
Cdd:TIGR02214 560 IKPQMNQGEApAAATNQVEAVAVPNLRGMKVDDAEKTLLHLGLDVAteGFGTRVVNQTPIPGEKVKEGTKVVLYLGE 636
|
|
| FtsI |
COG0768 |
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ... |
1-564 |
0e+00 |
|
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain] Cd Length: 568 Bit Score: 646.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 1 MRVSNVT--VRKRLIFILISGILIFTIIDIRLGYVQFFLGNMLTDRAKDSWSRNITFEPERGKILDRNGVELATNKSAPT 78
Cdd:COG0768 1 MKRKKEKrlFRRRLLLLFLLVLLLFLLLVGRLFYLQVVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 79 VFVVPRQIEKPAETAEKLAAVLGVEKDEIYKRITKKESI-VRLdkgGRKISHDKAKEVRGLSLKGVYIAEDSIRYYPFGN 157
Cdd:COG0768 81 LYADPEEVKDPEETAEKLAKLLGLDPEELRKKLKKKSRFpVYL---KRNLSPEEAARIRALKLPGVYVEAEYKRYYPYGE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 158 FLSHVLGFAGS----DNQGLMGLEKYYDKELNGDEGHVRFFADAKGQRMPNVGDDfKKPEAGLNLGLTIDARINRIMERE 233
Cdd:COG0768 158 LAAHVLGYVGEinggDGIGKSGLEKAYEDLLRGTPGKRRVEVDARGRVIRDLGEE-KPPVPGKDLVLTIDSDLQKIAEEA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 234 MNIAESTYNPDGMIAIAMNPKNGEILGMSSRPSFDPADFQSVSPEVYnRNLPVWSTYEPGSTFKIITLAAALNENLVDLE 313
Cdd:COG0768 237 LKKAVEEYKAKSGAVVVMDPKTGEILAMASYPSFDPNLFVGGPDEPL-RNRAVQGTYEPGSTFKPFTAAAALEEGVITPD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 314 kDTFYDDGAAEVGGARLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGQKTGIDLQGEGSGILF 393
Cdd:COG0768 316 -TTFDCPGYYRVGGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGLGQKTGIDLPGEASGLLP 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 394 NLDKVGPVEQATTSFGQGVSVTPIQQVAAVAAAVNGGTLYQPYIAKEFIDPKNNQVvsKKTPVEKRKVISKETSEKVRYA 473
Cdd:COG0768 395 SPKRWYPGETATMSIGQGLSVTPLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVV--KEEPEVLRRVISPETAETVREG 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 474 LENVV--AKGSGKGAFIDGYRVGGKTGTAQKV--KDGKYLENNYIVSFIGFAPADDPEIVVYVAVDNPKGvTQFGGVVAA 549
Cdd:COG0768 473 MEGVVnePGGTARRAAIPGYRVAGKTGTAQVVdiGNGGYYKGRHIASFVGFAPADNPRYAVAVVVENPGG-GAYGGTVAA 551
|
570
....*....|....*
gi 872563045 550 PIVGNILRDALPVMG 564
Cdd:COG0768 552 PVFREIMEAYLRLLG 566
|
|
| pbp2_mrdA |
TIGR03423 |
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ... |
10-560 |
2.67e-129 |
|
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain] Cd Length: 592 Bit Score: 393.04 E-value: 2.67e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 10 KRLIFILISGILIFTIIDIRLGYVQFFLGNMLTDRAKDSWSRNITFEPERGKILDRNGVELATNKSAPTVFVVPRQIEKP 89
Cdd:TIGR03423 1 RRALVLGGLVLALFGVLAARLFYLQVIRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIVPEKVDDL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 90 AETAEKLAAVLGVEKDEIyKRITKK-------ESIVRLDKggrkISHDK-AK-EVRGLSLKGVYIAEDSIRYYPFGNFLS 160
Cdd:TIGR03423 81 DATLDRLAKLLDLDPEDI-ARFLKElkrsrrfEPIPLKSD----LTEEEvARfAVNQYRLPGVEIEARLKRYYPYGELAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 161 HVLG-----------------FAGSDNQGLMGLEKYYDKELNGDEGHVRFFADAKGQRMPNVGDdfKKPEAGLNLGLTID 223
Cdd:TIGR03423 156 HVLGyvgeineedlerlepanYAGGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVIRTLSR--VPPVPGKDLVLTID 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 224 ARINRIMEREMniaestynpDGMI--AIAMNPKNGEILGMSSRPSFDPADF-QSVSPEVYNR----------NLPVWSTY 290
Cdd:TIGR03423 234 ARLQQAAEKAL---------GGRRgaVVVMDPRTGEILAMVSTPSFDPNLFvDGISSKDYKAllndpdrpllNRAIQGVY 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 291 EPGSTFKIITLAAALNENLVDlEKDTFYDDGAAEVGGARLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKY 370
Cdd:TIGR03423 305 PPGSTFKPVVALAALEEGVIT-PETRIYCPGYFQLGGRRFRCWKRGGHGRVDLRKAIEESCDVYFYQLALRLGIDKIAEY 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 371 IRNFGFGQKTGIDLQGEGSGIL--------------FNLDKVgpveqaTTSFGQG-VSVTPIQQVAAVAAAVNGGTLYQP 435
Cdd:TIGR03423 384 AKRFGFGQKTGIDLPGEKSGLVpsrewkrkrfgqpwYPGDTL------NVSIGQGyVLVTPLQLAVATAALANGGKLYKP 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 436 YIAKEFIDPKNNQVVSKKTPVEKRKVISKETSEKVRYALENVV--AKGSGKGAFID-GYRVGGKTGTAQKVK---DGKYL 509
Cdd:TIGR03423 458 HLVKSIEDPDGGVVRRTEPEVLRPLPISPENLDVVREGMRDVVngPGGTARRARLGlPYKMAGKTGTAQVVSlkqGEKYD 537
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*..
gi 872563045 510 ENNYIVS------FIGFAPADDPEIVVYVAVDNPKGvtqfGGVVAAPIVGNILRDAL 560
Cdd:TIGR03423 538 AEQIPERlrdhalFVAFAPYDNPKIAVAVIVEHGGG----GSSAAAPIARKIMDAYL 590
|
|
| Transpeptidase |
pfam00905 |
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ... |
246-556 |
1.57e-91 |
|
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain] Cd Length: 296 Bit Score: 285.08 E-value: 1.57e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 246 MIAIAMNPKNGEILGMSSRPSFDPADFQSvspevYNRNLPVWSTYEPGSTFKIITLAAALNENLVDLEKDTFYDDGAAEv 325
Cdd:pfam00905 1 GSAVVLDPKTGEVLAMVGKPSYDPNGFIG-----PLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWPGKQQ- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 326 GGARLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGQKTGIDLQGEGSGILFNLDkvgpVEQAT 405
Cdd:pfam00905 75 GGKSIGDWNQDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYGNKTGIGLPGENAGYLTPYW----LEGAT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 406 TSFGQGVSVTPIQQVAAVAAAVNGGTLYQPYIAKEFIDpknnqvvSKKTPVEKRKVISKETSEKVRYALENVVAKGSGKG 485
Cdd:pfam00905 151 ASFGIGLTITPLQQAQAYAAIANGGKLVPPHLVKSIED-------KVDPKVLNKLPISKSTAEKVKDMLRLVVNDGTGTG 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 872563045 486 AF-IDGYRVGGKTGTAQKV--KDGKYLENNYIVSFIGFAPADDPEIVVYVAVDNPKGvtQFGGVVAAPIVGNIL 556
Cdd:pfam00905 224 TAaVPGYKVAGKTGTAQVAgpKGGGYYDGAQIGWFVGYAPADNPKYAFAVLIDDPKR--YYGGKVAAPIFKDIL 295
|
|
| PRK15105 |
PRK15105 |
peptidoglycan synthase FtsI; Provisional |
14-567 |
3.97e-67 |
|
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain] Cd Length: 578 Bit Score: 229.71 E-value: 3.97e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 14 FILISGILIFTIID--IRLGYVQFFLGNMLTdRAKDSWSRNITFEP-ERGKILDRNGVELATNKSAPTVFVVPRQI-EKP 89
Cdd:PRK15105 23 FALLCGCILLALVFllGRVAWLQVINPDMLV-REGDMRSLRVQEVStSRGMITDRSGRPLAVSVPVKAIWADPKEVhDAG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 90 AETAEK----LAAVLGVEKDEIYKRI--TKKESIVRLdkgGRKISHDKAKEVRGLSLKGVYIAEDSIRYYPFGNFLSHVL 163
Cdd:PRK15105 102 GISVDDrwkaLADALNIPLDQLSARInaNPKGRFIYL---ARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 164 GFAGSDNQGLMGLEKYYDKELNGDEGHVRFFADAKGQRMPNVGddFKKPEAGLNLGLTIDARINRIMEREMNIAESTYNP 243
Cdd:PRK15105 179 GFTNVDSQGIEGVEKSFDKWLTGQPGERIVRKDRYGRVIEDIS--STDSQAAHNLALSIDERLQALVYRELNNAVAFNKA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 244 DGMIAIAMNPKNGEILGMSSRPSFDPADFQSVSPEVYnRNLPVWSTYEPGSTFKIITLAAALNENLVdlEKDTFYDDGAA 323
Cdd:PRK15105 257 ESGSAVLVDVNTGEVLAMANSPSYNPNNLSGTPKDAM-RNRAITDVFEPGSTVKPMVVMTALQRGVV--KENSVLNTVPY 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 324 EVGGARLKcwKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGQKTGIDLQGEGSGILFNLDKVGPVEQ 403
Cdd:PRK15105 334 RINGHEIK--DVARYSELTLTGVLQKSSNVGVSKLALAMPSSALVDTYSRFGLGKATNLGLVGERSGLYPQKQRWSDIER 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 404 ATTSFGQGVSVTPIQQVAAVAAAVNGGtLYQPY-IAKefIDPknnqvvskktPVEKRKVISKETSEKVRYALENV-VAKG 481
Cdd:PRK15105 412 ATFSFGYGLMVTPLQLARVYATIGSYG-IYRPLsITK--VDP----------PVPGERVFPESIVRTVVHMMESVaLPGG 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 482 SGKGAFIDGYRVGGKTGTAQKV-KDGKYLeNNYIVSFIGFAPADDPEIVVYVAVDNPKGVTQFGGVVAAPIVGNILRDAL 560
Cdd:PRK15105 479 GGVKAAIKGYRIAIKTGTAKKVgPDGRYI-NKYIAYTAGVAPASQPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVL 557
|
....*..
gi 872563045 561 PVMGVKP 567
Cdd:PRK15105 558 RTMNIEP 564
|
|
| PRK10795 |
PRK10795 |
penicillin-binding protein 2; Provisional |
12-560 |
1.37e-42 |
|
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain] Cd Length: 634 Bit Score: 163.02 E-value: 1.37e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 12 LIFILISGILIFTiidirLGYVQFFLGNMLTDRAKDSWSRNITFEPERGKILDRNGVELATNKSAPTVFVVPRQIEKPAE 91
Cdd:PRK10795 27 LGILLLTGVLIAN-----LYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGTPLALNRTIYQLEMMPEKVDNLQQ 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 92 TAEKLAAVLGVEKDEI------YKRITKKESI-VRLDKGGRKISHDKAKEVR--GLSLKGVyiaedSIRYYPFGNFLSHV 162
Cdd:PRK10795 102 TLDALRSVVDLTDDDIaafrkeRARSRRFTSIpVKTNLTEVQVARFAVNQYRfpGVEVKGY-----QRRYYPYGSALTHV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 163 LGF---------------------AGSDNQGLMGLEKYYDKELNGDEGHVRFFADAKGQRMPNVGDdfKKPEAGLNLGLT 221
Cdd:PRK10795 177 IGYvskindkdverldkegklanyAATHDIGKLGIERYYEDVLHGKTGYEEVEVNNRGRVIRQLHE--QPPQAGHDIYLT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 222 IDARINRIMEREMNIAESTynpdgmiAIAMNPKNGEILGMSSRPSFDPADF-QSVSPEVY-------NRNLPVWST---Y 290
Cdd:PRK10795 255 LDLKLQQYIETLLAGSRAA-------VVVTDPRTGGILALVSTPSYDPNLFvDGISSKDYsgllndpNRPLINRATqgvY 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 291 EPGSTFKIITLAAALNENLVDlEKDTFYDDGAAEVGGA--RLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLF 368
Cdd:PRK10795 328 PPASTVKPYVAVSALSAGVIT-RNTSLFDPGWWQLPGSekRYRDWKKWGHGRLNVTKSLEESADTFFYQVAYDMGIDRLS 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 369 KYIRNFGFGQKTGIDLQGEGSGILFNLD-KVG----PVEQATT---SFGQGV-SVTPIQQVAAVAAAVNGGTLYQPYIAK 439
Cdd:PRK10795 407 EWMGKFGYGHYTGIDLAEERSGNMPTREwKQKrfkkPWYQGDTipvGIGQGYwTATPIQMSKALMTLINDGIVKVPHLLM 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 440 EFIDpkNNQVVSKKTPVEKR--KVISK--ETSEKVRYALENvVAKGSGKGAFIDG-YRVGGKTGTAQ------------- 501
Cdd:PRK10795 487 STAE--DGKQVPWVQPHEPPvgDIHSGywEIAKDGMYGVAN-RPNGTAHKYFASApYKIAAKSGTAQvfglkanetynah 563
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 872563045 502 ----KVKDGKYLennyivsfIGFAPADDPEIVVYVAVDNpkgvtqfGGvvAAPIVGNILRDAL 560
Cdd:PRK10795 564 kiaeRLRDHKLM--------TAFAPYNNPQVAVAIILEN-------GG--AGPAVGTIMRQIL 609
|
|
| MrcB |
COG0744 |
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ... |
221-567 |
4.62e-36 |
|
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain] Cd Length: 630 Bit Score: 143.52 E-value: 4.62e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 221 TIDARINRIMEREMN--IAESTYNPDGMIAIAMNPKNGEILGM-SSRpsfDPADFQsvspevYNRNLPvwSTYEPGSTFK 297
Cdd:COG0744 300 TLDPKLQKAAEKAVKnvLPEGKPGGLQAALVVVDPKTGEVLAMvGGR---DYGKSQ------FNRATQ--AKRQPGSTFK 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 298 IITLAAALNENLvdlEKDTFYDDGAAEV--GGARLKCWKAGGHGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFG 375
Cdd:COG0744 369 PFVYAAALEQGY---TPATTVDDEPVTFpgGGWSPKNYDGRYRGPVTLREALANSLNTPAVRLAQEVGLDKVVDTARRLG 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 376 FGQKtgidlqgegsgilfnldkvgpvEQATTSFGQGVS-VTPIQQVAAVAAAVNGGTLYQPYIAKEFIDPkNNQVVSKKT 454
Cdd:COG0744 446 ITSP----------------------LDPNPSLALGTSeVSPLEMASAYATFANGGVYVEPHAITKVTDA-DGKVLYEAK 502
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 455 PVEKRkVISKETSEKVRYALENVVAKGSGKGAFIDGYRVGGKTGTAQKVKDgkylennyiVSFIGFapadDPEIVVYVAV 534
Cdd:COG0744 503 PKCEQ-VISPEVAYLMTDMLQDVVTSGTGRAARLPGRPVAGKTGTTNDNRD---------AWFVGY----TPQLVTAVWV 568
|
330 340 350
....*....|....*....|....*....|....*.
gi 872563045 535 --DNPKGVTQ-FGGVVAAPIVGNILRDALPVMGVKP 567
Cdd:COG0744 569 gnDDNSPMGYvTGGSLPAPIWRDFMEAALEGLPVED 604
|
|
| PBP_dimer |
pfam03717 |
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ... |
56-201 |
3.82e-27 |
|
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain] Cd Length: 178 Bit Score: 108.18 E-value: 3.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 56 EPERGKILDRNGVELATNKSAPTVFVVPRQIEK--PAETAEKLAAVLGVEKDEIYKRITKKesIVRLDKGG--------R 125
Cdd:pfam03717 3 PAPRGEIYDRNGVVLATNKPVYSLTITPSKLKKadALKTALKLAKLLSNYEDLDDEDLTER--FLKMNSYKsyypvvikK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 126 KISHDKAKEVRGLS--LKGVYIAEDSIRYYPFGNFLSHVLGFAGSDNQ-----------------GLMGLEKYYDKELNG 186
Cdd:pfam03717 81 NLSEEEVARIEENLleLPGVSIETDPVRYYPYGELAAHLLGYVGEITEeelekyldkgysrgdlvGKSGLEKQYESVLRG 160
|
170
....*....|....*
gi 872563045 187 DEGHVRFFADAKGQR 201
Cdd:pfam03717 161 KDGVRQVEVDALGRV 175
|
|
| PASTA |
cd06573 |
PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins ... |
585-636 |
1.66e-20 |
|
PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Pssm-ID: 119325 [Multi-domain] Cd Length: 53 Bit Score: 85.07 E-value: 1.66e-20
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 872563045 585 EVPNLIGMKKKDLQTQLVD-LKLDISGDGEKVIKQSPEAGAKVKEGSKIRIYF 636
Cdd:cd06573 1 EVPDLVGISKKDLEEQLYDlLKLDASGSGNKVVKQSPEAGTKVAEGSTIRIYL 53
|
|
| MrcA |
COG5009 |
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis]; |
249-560 |
6.13e-12 |
|
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain] Cd Length: 785 Bit Score: 68.65 E-value: 6.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 249 IAMNPKNGEILGMSSrpSFDPADFQsvspevYNRnlpvwSTY---EPGSTFKIITLAAALNE--NLVDLEKD---TFYDD 320
Cdd:COG5009 426 VALDPHTGAVLALVG--GFDFEQSK------FNR-----ATQakrQPGSSFKPFVYAAALDNgyTPATIINDapiVFDDG 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 321 GAAEVggarlkcWK---AGG--HGSQTFLEVVQNSCNPGFIELGDRLGKDRLFKYIRNFGFGqktgidlqgegsgilfnl 395
Cdd:COG5009 493 GGGGV-------WRpknYSGkfYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGIY------------------ 547
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 396 DKVGPVEqaTTSFGQGvSVTPIQQVAAVAAAVNGGTLYQPYiakeFID---PKNNQVVSKKTPV---------------- 456
Cdd:COG5009 548 SKLPPNL--SLALGSG-EVTPLEMARAYAVFANGGYRVEPY----LIDrieDRNGKVIYRADPAracedcdaaewdgaep 620
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 457 ----EKRKVISKETSEKVRYALENVVAKGSGKGAFIDGYRVGGKTGTAQKVKDgkylennyiVSFIGFApaddPEIV--V 530
Cdd:COG5009 621 rlpdPAEQVIDPRTAYQMTSMLRGVVQRGTGRRARALGRDIAGKTGTTNDSKD---------AWFVGFT----PDLVagV 687
|
330 340 350
....*....|....*....|....*....|..
gi 872563045 531 YVAVDNPK--GVTQFGGVVAAPIVGNILRDAL 560
Cdd:COG5009 688 WVGFDDPRslGRGETGGRAALPIWIDFMKAAL 719
|
|
| PASTA |
smart00740 |
PASTA domain; |
582-637 |
2.23e-11 |
|
PASTA domain;
Pssm-ID: 197851 [Multi-domain] Cd Length: 67 Bit Score: 59.63 E-value: 2.23e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 872563045 582 PTVEVPNLIGMKKKDLQTQLVDLKLDI--------SGDGEKVIKQSPEAGAKVKEGSKIRIYFG 637
Cdd:smart00740 3 EKVEVPDVIGKSKEEAKKLLKALGLKVevveeyssDGEEGTVISQSPAAGTTVKPGSKVTLTVS 66
|
|
| PASTA |
pfam03793 |
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ... |
584-638 |
2.91e-11 |
|
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Pssm-ID: 461053 [Multi-domain] Cd Length: 63 Bit Score: 59.17 E-value: 2.91e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 872563045 584 VEVPNLIGMKKKDLQTQLVDLKL---------DISGDGeKVIKQSPEAGAKVKEGSKIRIYFGN 638
Cdd:pfam03793 1 VTVPDVVGLSLEEAKKLLEALGLkvgtveeysDDVGEG-TVISQSPPAGTKVKKGSKVTLTVSK 63
|
|
| PASTA_Pbp2x-like_2 |
cd06575 |
PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the ... |
586-637 |
9.53e-11 |
|
PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Pssm-ID: 119326 [Multi-domain] Cd Length: 54 Bit Score: 57.46 E-value: 9.53e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 872563045 586 VPNLIGMKKKDLQT--QLVDLKLDISGDGeKVIKQSPEAGAKVKEGSKIRIYFG 637
Cdd:cd06575 2 MPDLTGWSKRDALKllELLGLKVKFSGSG-YVVSQSIAPGTKVKKGTTITVTLK 54
|
|
| PASTA_Pbp2x-like_1 |
cd06576 |
PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the ... |
585-637 |
3.42e-10 |
|
PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Pssm-ID: 119327 [Multi-domain] Cd Length: 55 Bit Score: 55.98 E-value: 3.42e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 872563045 585 EVPNLIGMKKKDLQTQLVDLKLD--ISGDGEKVIKQSPEAGAKVKEGSKIRIYFG 637
Cdd:cd06576 1 KVPDVTGKSVEEAKKELKEAGLQpvVIGNGKKVKKQSPKPGEKVLEGSKVLLYTD 55
|
|
| PASTA_pknB |
cd06577 |
PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a ... |
585-635 |
1.02e-09 |
|
PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis. PknB is a receptor-like transmembrane protein with an extracellular signal sensor domain (containing multiple PASTA domains) and an intracellular, eukaryotic serine/threonine kinase-like domain. The PASTA domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Pssm-ID: 119328 [Multi-domain] Cd Length: 62 Bit Score: 54.84 E-value: 1.02e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 585 EVPNLIGMKKKDLQTQLVDLKLDISGDGE---------KVIKQSPEAGAKVKEGSKIRIY 635
Cdd:cd06577 1 TVPDVVGMTLDEAKAALEAAGLKVGVVTEeysddvpkgTVISQSPAAGTKVKKGSTVTLT 60
|
|
| PknB_PASTA_kin |
NF033483 |
Stk1 family PASTA domain-containing Ser/Thr kinase; |
582-636 |
3.66e-09 |
|
Stk1 family PASTA domain-containing Ser/Thr kinase;
Pssm-ID: 468045 [Multi-domain] Cd Length: 563 Bit Score: 59.42 E-value: 3.66e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 872563045 582 PTVEVPNLIGMKKKDLQTQLVDLKLDISGDGE---------KVIKQSPEAGAKVKEGSKIRIYF 636
Cdd:NF033483 363 KEVTVPDVVGKTEAEAKEALEKAGLKVGKVEEeysddveegKVISTDPEAGTRVKEGSTVTLVV 426
|
|
| PASTA |
COG2815 |
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis]; |
582-635 |
1.09e-08 |
|
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442064 [Multi-domain] Cd Length: 220 Bit Score: 56.04 E-value: 1.09e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 872563045 582 PTVEVPNLIGMKKKDLQTQLVDLKLDISGDGE--------KVIKQSPEAGAKVKEGSKIRIY 635
Cdd:COG2815 23 EEVTVPDVVGMTVDEAEAALEEAGLKVEVEEEysddvpagTVISQDPAAGTKVKKGSTVTLT 84
|
|
| PASTA |
COG2815 |
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis]; |
582-635 |
2.37e-07 |
|
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442064 [Multi-domain] Cd Length: 220 Bit Score: 51.80 E-value: 2.37e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 872563045 582 PTVEVPNLIGMKKKDLQTQLVDLKLDI-------SGDGEK--VIKQSPEAGAKVKEGSKIRIY 635
Cdd:COG2815 90 EKVTVPDLVGKSLDEAEAALEAAGLKVgeveeeySDDVPKgtVISQSPAAGTEVPKGTTVTLV 152
|
|
| PknB_PASTA_kin |
NF033483 |
Stk1 family PASTA domain-containing Ser/Thr kinase; |
582-635 |
6.68e-07 |
|
Stk1 family PASTA domain-containing Ser/Thr kinase;
Pssm-ID: 468045 [Multi-domain] Cd Length: 563 Bit Score: 52.49 E-value: 6.68e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 872563045 582 PTVEVPNLIGMKKKDLQTQLVDLKLDI-------SGDGEK--VIKQSPEAGAKVKEGSKIRIY 635
Cdd:NF033483 431 EKVKVPDLTGKSLDEAKKALEDAGLKVgtieeeySDDVPKgtVISQDPAAGTEVDKGTTVTLT 493
|
|
| PASTA |
COG2815 |
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis]; |
583-634 |
1.03e-06 |
|
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442064 [Multi-domain] Cd Length: 220 Bit Score: 49.87 E-value: 1.03e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 872563045 583 TVEVPNLIGMKKKDLQTQLVDLKLDI-------SGDGEK--VIKQSPEAGAKVKEGSKIRI 634
Cdd:COG2815 159 PVTVPDLVGLTLEEAKAALEAAGLKVgvveeeySDDVPAgtVISQSPAAGTKVEKGSTVTL 219
|
|
| PknB_PASTA_kin |
NF033483 |
Stk1 family PASTA domain-containing Ser/Thr kinase; |
583-635 |
1.25e-06 |
|
Stk1 family PASTA domain-containing Ser/Thr kinase;
Pssm-ID: 468045 [Multi-domain] Cd Length: 563 Bit Score: 51.33 E-value: 1.25e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 872563045 583 TVEVPNLIGMKKKDLQTQLVDLKLDISGDGE---------KVIKQSPEAGAKVKEGSKIRIY 635
Cdd:NF033483 500 PVTVPDVTGMSEEEAKSALESAGLKVGVEEEevssdvpagTVISQSPAAGTEVAKGSTVTLT 561
|
|
| PRK14850 |
PRK14850 |
penicillin-binding protein 1b; Provisional |
412-562 |
3.01e-03 |
|
penicillin-binding protein 1b; Provisional
Pssm-ID: 237835 [Multi-domain] Cd Length: 764 Bit Score: 40.60 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872563045 412 VSVTPIQQVAAVAAAVNGGTlYQPYIAKEFIDPKNNQVVSKKTPVEKRkVISKETSEKVRYALENVVAKGSGK--GAFID 489
Cdd:PRK14850 556 INLTPMEVAQVFQIIGSGGY-KSSLSSIRSIISDDNKVLYQNFPQSKH-VESSQASYLTLYAMQQVVKSGTAKslGTIFK 633
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 872563045 490 GYRVGGKTGTAQKVKDGkylennyivSFIGFapaDDPEIVV-YVAVDNPKGVTQFGGVVAAPIVGNILRDALPV 562
Cdd:PRK14850 634 EFSLAGKTGTTNNLVDS---------WFVGI---DGKQVVItWIGRDNNHTTKLYGSSGAMKIYKRYLQYQNPV 695
|
|
| |
