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Conserved domains on  [gi|872564797|ref|WP_048530845|]
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MULTISPECIES: nitroreductase family protein [Bacillus]

Protein Classification

nitroreductase family protein( domain architecture ID 10114825)

nitroreductase family protein may catalyze the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles, requiring NAD(P)H as an electron donor in an obligatory two-electron transfer and using FMN as cofactor

CATH:  3.40.109.10
EC:  1.7.1.-
Gene Ontology:  GO:0016491
SCOP:  3001947

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
7-200 8.40e-54

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


:

Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 168.57  E-value: 8.40e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   7 FNVLYERTSTRAFNPEKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGDL 86
Cdd:cd02137    1 LEVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYNQPQVTTASAVILVLGDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  87 eayknvepvygpiveqgfmkeeakerlakniesayareqfprdaafsNASLAAMQLMLAAKATGWDTCAIGGFNPQALTE 166
Cdd:cd02137   81 -----------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAE 113
                        170       180       190
                 ....*....|....*....|....*....|....
gi 872564797 167 EFNVSSRYVPIMLITIGESTLKGHPAPRMSVEQV 200
Cdd:cd02137  114 LLNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
 
Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
7-200 8.40e-54

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 168.57  E-value: 8.40e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   7 FNVLYERTSTRAFNPEKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGDL 86
Cdd:cd02137    1 LEVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYNQPQVTTASAVILVLGDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  87 eayknvepvygpiveqgfmkeeakerlakniesayareqfprdaafsNASLAAMQLMLAAKATGWDTCAIGGFNPQALTE 166
Cdd:cd02137   81 -----------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAE 113
                        170       180       190
                 ....*....|....*....|....*....|....
gi 872564797 167 EFNVSSRYVPIMLITIGESTLKGHPAPRMSVEQV 200
Cdd:cd02137  114 LLNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
6-200 1.68e-42

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 140.37  E-value: 1.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   6 FFNVLYERTSTRAFNPEKeISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPI--AYNQQQILDASAVVAIL 83
Cdd:COG0778    1 LLELLLTRRSVRKFTDKP-VSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEAlaEANQEWVADAPVLIVVC 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  84 GDLEAYKNVepvygpiveqgfmkeeakerlakniesayareqfPRDAAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQA 163
Cdd:COG0778   80 ADPDRSEKV----------------------------------PERYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEK 125
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 872564797 164 LTEEFNVSSRYVPIMLITIGESTLKGHPAPRMSVEQV 200
Cdd:COG0778  126 VRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEV 162
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
10-183 2.35e-31

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 112.10  E-value: 2.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   10 LYERTSTRAFNPEKeISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGDLEAY 89
Cdd:pfam00881   1 IRQRRSVRKFDPEP-VPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAALLLLLRRDANL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   90 KNVEpvygpiveQGFMKEEAKERLAKNIESAYAR--EQFPRDAAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQALTEE 167
Cdd:pfam00881  80 KLLL--------QDFLRGAPVLIVITASLSTYLRkaAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVREL 151
                         170
                  ....*....|....*.
gi 872564797  168 FNVSSRYVPIMLITIG 183
Cdd:pfam00881 152 LGLPDDERLVGLIAVG 167
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
5-183 5.11e-15

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 70.38  E-value: 5.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   5 NFFNVLYERTSTRAFNPEKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDD----VQKRLHPI-AYNQQQILDASAV 79
Cdd:PRK11053   2 DIVSVAKKRYTTKAFDPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEgkarIAKAAAGNyAFNERKILDASHV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  80 VAILG--DL-EAYKNVepvygpIVEQG-----FMKEEAKErLAKNIESAYA---REQfPRDAAF---SNASLAAMQLMLA 145
Cdd:PRK11053  82 VVFCAktDMdDAYLEL------VLEQEdadgrFATEEAKA-AQDKGRRFFAdmhRKE-LKDLQHwmeKQVYLALGNLLLG 153
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 872564797 146 AKATGWDTCAIGGFNPQALTEEFNVSSR-YVPIMLITIG 183
Cdd:PRK11053 154 AAALGIDATPIEGFDAAILDAEFGLREKgLTSSVVVPLG 192
 
Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
7-200 8.40e-54

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 168.57  E-value: 8.40e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   7 FNVLYERTSTRAFNPEKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGDL 86
Cdd:cd02137    1 LEVIKSRRSVRNFDPDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAAYNQPQVTTASAVILVLGDL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  87 eayknvepvygpiveqgfmkeeakerlakniesayareqfprdaafsNASLAAMQLMLAAKATGWDTCAIGGFNPQALTE 166
Cdd:cd02137   81 -----------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAE 113
                        170       180       190
                 ....*....|....*....|....*....|....
gi 872564797 167 EFNVSSRYVPIMLITIGESTLKGHPAPRMSVEQV 200
Cdd:cd02137  114 LLNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
6-200 1.68e-42

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 140.37  E-value: 1.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   6 FFNVLYERTSTRAFNPEKeISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPI--AYNQQQILDASAVVAIL 83
Cdd:COG0778    1 LLELLLTRRSVRKFTDKP-VSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEAlaEANQEWVADAPVLIVVC 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  84 GDLEAYKNVepvygpiveqgfmkeeakerlakniesayareqfPRDAAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQA 163
Cdd:COG0778   80 ADPDRSEKV----------------------------------PERYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEK 125
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 872564797 164 LTEEFNVSSRYVPIMLITIGESTLKGHPAPRMSVEQV 200
Cdd:COG0778  126 VRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEV 162
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
13-198 1.11e-31

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 113.57  E-value: 1.11e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  13 RTSTRAFNPEkEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGDLE-AYKN 91
Cdd:cd03370    8 RRSIRKYTQE-PVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAAAYGQAQVTSAPAVIVIYSDMEdALAN 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  92 VEPVYGPiveqGFMkEEAKERLAKNIESAYAREQFPRDAAFSN--ASLAAMQLMLAAKATGWDTCAIGGFNPQALTEEFN 169
Cdd:cd03370   87 LEETIHP----GLS-EERRQREAAGLRGAFGKMSVEQRGQWGLaqANIALGFLLLAAQSLGYDTSPMLGFDPEKVKALLG 161
                        170       180
                 ....*....|....*....|....*....
gi 872564797 170 VSSRYVPIMLITIGESTLKGHPAPRMSVE 198
Cdd:cd03370  162 LPEHVTIAALVALGKPAEEGYPHHRHSLE 190
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
10-183 2.35e-31

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 112.10  E-value: 2.35e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   10 LYERTSTRAFNPEKeISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGDLEAY 89
Cdd:pfam00881   1 IRQRRSVRKFDPEP-VPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAALLLLLRRDANL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   90 KNVEpvygpiveQGFMKEEAKERLAKNIESAYAR--EQFPRDAAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQALTEE 167
Cdd:pfam00881  80 KLLL--------QDFLRGAPVLIVITASLSTYLRkaAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVREL 151
                         170
                  ....*....|....*.
gi 872564797  168 FNVSSRYVPIMLITIG 183
Cdd:pfam00881 152 LGLPDDERLVGLIAVG 167
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
5-200 1.81e-27

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 101.56  E-value: 1.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   5 NFFNVLYERTSTRAFNPEKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIA-YNQQQILDASAVVAIL 83
Cdd:cd02149    1 NILELLNFRYATKKFDPNKKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPAAwFNQPQIKDASHVVVFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  84 GDLEayknvepvygpiveqgfmkeeakerlakniesaYAREQfprdaafsnASLAAMQLMLAAKATGWDTCAIGGFNPQA 163
Cdd:cd02149   81 AKKD---------------------------------WSAKQ---------TYIALGNMLLAAAMLGIDSCPIEGFDPAK 118
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 872564797 164 LTEEFNVS-SRYVPIMLITIGESTLKGHPAPRMSVEQV 200
Cdd:cd02149  119 LDEILGLDeKGYKISVMVAFGYRSEEKLPKSRKPLEDV 156
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
13-183 1.05e-22

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 88.89  E-value: 1.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  13 RTSTRAFNPeKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLH-PIAYNQQQILDASAVVAILGDLEAYKN 91
Cdd:cd02062    4 RRSIRKFTD-KPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAkLAAPNQKFIAGAPVVIVVVADPDKSRP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  92 VepvygpiveqgfmkeeakerlakniesayareqfprdaAFSNASLAAMQLMLAAKATGWDTCAIGGFN--PQALTEEFN 169
Cdd:cd02062   83 W--------------------------------------ALEDAGAAAQNLLLAAAALGLGSCWIGGFDfrEDKVRELLG 124
                        170
                 ....*....|....
gi 872564797 170 VSSRYVPIMLITIG 183
Cdd:cd02062  125 IPENLRPVALIAIG 138
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
12-183 1.55e-19

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 81.44  E-value: 1.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  12 ERTSTRAFNPEkEISSTELHEILKGAAQAPSAWNLQHWKFLV-FQGDDVQKRLH--PIAYNQQQILDASAVVAILgdlea 88
Cdd:cd02138    4 ERWSPRAFSPE-PISEEDLLSLFEAARWAPSCFNEQPWRFVVaRRDTEAFEKLLdlLAEGNQSWAKNAPVLIVVL----- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  89 yknvepvygpiveqgfmkeeAKERLAKNIEsayareqfPRDAAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQALTEEF 168
Cdd:cd02138   78 --------------------AKTEFDHNGK--------PNRYALFDTGAAVANLALQATALGLVVHQMAGFDPEKAKEAL 129
                        170
                 ....*....|....*
gi 872564797 169 NVSSRYVPIMLITIG 183
Cdd:cd02138  130 GIPDEYEPITMIAIG 144
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
5-183 7.02e-19

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 78.97  E-value: 7.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   5 NFFNVLYERTSTRAFNPeKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNqqqILDASAVVAILG 84
Cdd:cd20609    1 DFLELAKKRYSVRKFSD-KPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKATPR---FFGAPLVIVVCY 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  85 DLEAyknvepvygpiveqgfmkeeakerlakniesAYAREQFPRDAAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQAL 164
Cdd:cd20609   77 DKDE-------------------------------SWKRPYDGKDSGDIDAAIVATHMMLAATELGLGTCWVGNFDPEKV 125
                        170
                 ....*....|....*....
gi 872564797 165 TEEFNVSSRYVPIMLITIG 183
Cdd:cd20609  126 REAFNLPENLEPVAILPLG 144
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
15-200 8.26e-19

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 79.99  E-value: 8.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  15 STRAFNPeKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHP--IAYNQQQILDASaVVAILG-DLEAYKN 91
Cdd:cd02148   11 THNAWED-KPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPhlSEGNREKTMAAP-VTAILAyDTEFYEH 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  92 VEPVYgPIVEqgfmkeEAKERLAKNIESAYAreqfprdAAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQALTEEFNVS 171
Cdd:cd02148   89 LPRLF-PHGD------ARSWFFGSGPARAEE-------TAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAG 154
                        170       180       190
                 ....*....|....*....|....*....|...
gi 872564797 172 SRYVPIMLITIG---ESTLkgHP-APRMSVEQV 200
Cdd:cd02148  155 TRWKSNLVVNLGygdPSKL--FPrLPRLDFDEA 185
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
6-200 6.12e-17

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 74.43  E-value: 6.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   6 FFNVLYERTSTRAFNPeKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGD 85
Cdd:cd02139    1 VYEAIKKRRSIRKYKP-TPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAEAANGQKFIAEAPVVIVACAD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  86 leayknvEPVYGPIVEQgfmkeeakerlakniesayarEQFPRDAAFsnaslaAMQ-LMLAAKATGWDTCAIGGFNPQAL 164
Cdd:cd02139   80 -------PSESGMGCGK---------------------PYYLVDVAI------AMEhLVLAATEEGLGTCWIGAFDEDKV 125
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 872564797 165 TEEFNVSSRYVPIMLITIGESTLKGHPAPRMSVEQV 200
Cdd:cd02139  126 KEILGIPEEYRVVALTPLGYPAEEPPPRPRKPLEEI 161
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
5-183 5.11e-15

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 70.38  E-value: 5.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   5 NFFNVLYERTSTRAFNPEKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDD----VQKRLHPI-AYNQQQILDASAV 79
Cdd:PRK11053   2 DIVSVAKKRYTTKAFDPSKKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEgkarIAKAAAGNyAFNERKILDASHV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  80 VAILG--DL-EAYKNVepvygpIVEQG-----FMKEEAKErLAKNIESAYA---REQfPRDAAF---SNASLAAMQLMLA 145
Cdd:PRK11053  82 VVFCAktDMdDAYLEL------VLEQEdadgrFATEEAKA-AQDKGRRFFAdmhRKE-LKDLQHwmeKQVYLALGNLLLG 153
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 872564797 146 AKATGWDTCAIGGFNPQALTEEFNVSSR-YVPIMLITIG 183
Cdd:PRK11053 154 AAALGIDATPIEGFDAAILDAEFGLREKgLTSSVVVPLG 192
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
9-200 1.99e-12

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 62.22  E-value: 1.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   9 VLYERTSTRAFNPeKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGdDVQKRLHPIAYnqqqilDASAVVAILGDlea 88
Cdd:cd02136    1 AIKSRRSVRAFKD-KPVPKETIEKILEAARRAPSGKNTQPWRVYVVTG-KARERLKKAFF------GAPVALFLTMD--- 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  89 yknvePVYGPiveqgfmkeeakerlakniesayareqfprdAAFSNASLAAMQLMLAAKATGWDTCAIG---GFNPQALt 165
Cdd:cd02136   70 -----KVLGP-------------------------------WSWFDLGAFLQNLMLAAHALGLGTCPQGalaGYPDVVR- 112
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 872564797 166 EEFNVSSRYVPIMLITIG----ESTLKGHPAPRMSVEQV 200
Cdd:cd02136  113 KELGIPDDEELVCGIALGypdpDAPVNQFRTPREPLEEF 151
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
13-200 2.63e-12

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 63.41  E-value: 2.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  13 RTSTRAFNPEkEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGDLeaYKNv 92
Cdd:cd02146    8 HRSVRKFTDE-PLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAELAGNQPYVAQAPVFLVFCADL--YRH- 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  93 epvyGPIVEQGFMKEEAkerlAKNIESAYareqfprdAAFSNASLAAMQLMLAAKATGWDTCAIGGF--NPQALTEEFNV 170
Cdd:cd02146   84 ----QKIAEEAGGKDVG----LDYLESFL--------VGVVDAALAAQNALVAAESLGLGIVYIGGIrnNPEEVIELLGL 147
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 872564797 171 SSRYVPIMLITIgestlkGHPA------PRMSVEQV 200
Cdd:cd02146  148 PEYVFPLFGLTV------GHPDptpevkPRLPLEAV 177
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
22-204 4.08e-12

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 62.14  E-value: 4.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  22 EKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHP--IAYNQQQILDASaVVAILG-DLEAYKNVEPVygp 98
Cdd:PRK05365  24 DEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPalSEGNLAKTLAAP-VTAIVAyDTEFHEHLPKL--- 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  99 iveqgFMKEEAKERLAKNIESAYAreqfprdAAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQALTEEFNVSSRYVPIM 178
Cdd:PRK05365 100 -----FPHADARSWFAGNPALAEE-------TAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAGTTWKSNF 167
                        170       180       190
                 ....*....|....*....|....*....|
gi 872564797 179 LITIG---ESTLkgHP-APRMSVEQVSEWA 204
Cdd:PRK05365 168 LVNIGygdPAKL--FPrLPRLSFDEACRIL 195
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
10-183 5.16e-11

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 58.38  E-value: 5.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  10 LYERTSTRAFNpEKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILDASAVVAILGDLEay 89
Cdd:cd02150    1 ILTRRSIRKYT-DKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAEAHPYGKMLKEAPLAIVVCGDPS-- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  90 knvepvygpiveqgfmKEEAKerlakniesayareqfprDAAFSNASLAAMQLMLAAKATGWDTCAIGGF----NPQALT 165
Cdd:cd02150   78 ----------------KEKAP------------------GYWVQDCSAATENILLAAHALGLGAVWLGVYpfeeRVKAIR 123
                        170
                 ....*....|....*...
gi 872564797 166 EEFNVSSRYVPIMLITIG 183
Cdd:cd02150  124 EILNIPENIIPFCVIALG 141
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
10-154 1.17e-08

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 52.28  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  10 LYERTSTRAFNPeKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHpIAYNqqqildasavvAILGDLEAY 89
Cdd:cd20610    1 IKKRRSIRKFKP-DPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKIG-ISIK-----------KKNEEIARL 67
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 872564797  90 KNVEPVYGPIVEQGFMKEEAKERLAKNIESAYAR---EQFPRDAAFSNASlAAMQ-LMLAAKATGWDTC 154
Cdd:cd20610   68 LEKVFAEKPIRFRKFRRFFTLFGGAPVLVVVYTEpykPPEERKPDLQSVS-AAIQnLLLAAHALGLGTC 135
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
8-192 9.67e-08

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 49.45  E-value: 9.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   8 NVLYERTSTRAFNPEKeISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRL-HPIAYNQQQILDASAVVAILGDl 86
Cdd:cd02151    1 ELLKKRRSIRKYTDEP-IEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLsECKPHGSAFLKGAPAAIVVLAD- 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  87 eayKNVEPVYgpiveqgfmkeeakerlaknIEsayareqfprdaafsNASLAAMQLMLAAKATGWDTCAI---GGFNPQA 163
Cdd:cd02151   79 ---TEKSDTW--------------------IE---------------DASIAATYIQLAAESLGLGSCWIqirNRETQDG 120
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 872564797 164 LT------EEFNVSSRYVPIMLITIG--ESTLKGHPA 192
Cdd:cd02151  121 KTaeeyvrELLGIPENYRVLCIIALGypDEEKPPHED 157
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
9-183 1.72e-07

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 48.75  E-value: 1.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   9 VLYERTSTRAFNPEKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKrlhpiaynqqqildasavvaiLGDL-- 86
Cdd:cd02135    3 LIKTRRSIRKFKLTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRER---------------------LAELla 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  87 EAYKNVEPVygpiveqgfMKEEAKERLAKNIESAYA----------REQFPRDAAFSNASLAAMQLMLAAKATG----WD 152
Cdd:cd02135   62 AAAAARAPG---------ADPEKLEKAREKALRAPVviavvakpdeDPKVPEWEQYAAVGAAVQNLLLAAHALGlgavWR 132
                        170       180       190
                 ....*....|....*....|....*....|.
gi 872564797 153 TCAIgGFNPqALTEEFNVSSRYVPIMLITIG 183
Cdd:cd02135  133 TGPV-TYDP-AVREALGLPEDERIVGFLYLG 161
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
7-183 1.80e-07

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 48.49  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   7 FNVLYERTSTRAFNPeKEISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIAYNQQQILdASAVVAILGdl 86
Cdd:cd20608    1 FEAIKTRRSVRRFSD-KPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSELAKKESPSNGWL-KDAPVIIVV-- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  87 eaykNVEPvygpiveqgfmkEEAKERlakniesaYAREQFPRDAAfsnasLAAMQLMLAAKATGWDTCAIGGFNPQALTE 166
Cdd:cd20608   77 ----CADP------------KDSGWL--------NGQNYYLVDAA-----IAMQNLMLAATDLGLGTCWIGAFDEKKVKE 127
                        170
                 ....*....|....*..
gi 872564797 167 EFNVSSRYVPIMLITIG 183
Cdd:cd20608  128 ILGIPENIRVVALTPLG 144
McbC_SagB-like_oxidoreductase cd02142
oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain ...
1-183 1.63e-05

oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.


Pssm-ID: 380318  Cd Length: 200  Bit Score: 43.95  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797   1 MTNDNFFNVLYERTSTRAF----NPEKEISSTELHEILKGAA---QAPSAWNL-------------------------QH 48
Cdd:cd02142   15 LATLDLSEALLNRRSRRTFssepLTLRELSRLAARGIPGSGYglrPYPSAGALypievyvivknveglpagiyhydpkRH 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872564797  49 WKFLVFQGDDVQKRLHPiAYNQQQILDASAVVAILGDLEAYknvEPVYGpiveqgfmkeeakerlakniESAYAReqfpr 128
Cdd:cd02142   95 RLVLIREGDFRLDLAHA-AGNQAAFGSAAFSLIIVARFERI---AWKYG--------------------ERAYRY----- 145
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 872564797 129 daAFSNASLAAMQLMLAAKATGWDTCAIGGFNPQALTEEFNVS-SRYVPIMLITIG 183
Cdd:cd02142  146 --ILLEAGHLAQNLYLAATALGLGLCAIGAFDDDALRELLGLDeVEEVVLYAFVVG 199
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
13-67 3.88e-04

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 39.83  E-value: 3.88e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 872564797  13 RTSTRAFNPEKeISSTELHEILKGAAQAPSAWNLQHWKFLVFQGDDVQKRLHPIA 67
Cdd:cd02144    8 RRSVRDFSSEP-VPREVIENAIRTAGTAPSGANTQPWTFVVVSDPEIKRKIREAA 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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