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Conserved domains on  [gi|872571191|ref|WP_048531797|]
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MULTISPECIES: ankyrin repeat domain-containing protein [Bacillus cereus group]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-213 4.27e-42

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.33  E-value: 4.27e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  30 NMETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 110 LHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRtSVDVNHVNNLGWTALMEAIVLSNGNetqqqVIRLLI 189
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLE-----IVKLLL 239

                        170       180
                 ....*....|....*....|....
gi 872571191 190 EHGADVTIPDNDDVTPLEHARAHN 213
Cdd:COG0666  240 EAGADLNAKDKDGLTALLLAAAAG 263
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-213 4.27e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.33  E-value: 4.27e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  30 NMETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 110 LHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRtSVDVNHVNNLGWTALMEAIVLSNGNetqqqVIRLLI 189
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLE-----IVKLLL 239

                        170       180
                 ....*....|....*....|....
gi 872571191 190 EHGADVTIPDNDDVTPLEHARAHN 213
Cdd:COG0666  240 EAGADLNAKDKDGLTALLLAAAAG 263
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-208 1.52e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 86.23  E-value: 1.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  31 METSLLAATEKQETNTVI---SLLKKGADINITDSKGRTPL---MIATYKNDVKTAKALIEAGADVNIQDDMKNNPF-LY 103
Cdd:PHA03095  11 MEAALYDYLLNASNVTVEevrRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLY 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 104 AGAEGYLHILKLTIDAGADPSLTNRYGGTALipaseHGYI-------DVINELLtRTSVDVNHVNNLGWTALmeAIVLSN 176
Cdd:PHA03095  91 LYNATTLDVIKLLIKAGADVNAKDKVGRTPL-----HVYLsgfninpKVIRLLL-RKGADVNALDLYGMTPL--AVLLKS 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 872571191 177 GNETqQQVIRLLIEHGADVTIPDNDDVTPLEH 208
Cdd:PHA03095 163 RNAN-VELLRLLIDAGADVYAVDDRFRSLLHH 193
Ank_2 pfam12796
Ankyrin repeats (3 copies);
101-199 1.69e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.98  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  101 FLYAGAEGYLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRtsVDVNHVNNlGWTALMEAIvlSNGNEt 180
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAA--RSGHL- 74

                          90
                  ....*....|....*....
gi 872571191  181 qqQVIRLLIEHGADVTIPD 199
Cdd:pfam12796  75 --EIVKLLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-134 1.01e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  63 KGRTPLMIATYKNDVKTAKALIEAGADVN--------IQDDMKN------NPFLYAGAEGYLHILKLTIDAGADPSLTNR 128
Cdd:cd22192   88 QGETALHIAVVNQNLNLVRELIARGADVVspratgtfFRPGPKNliyygeHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167


                 ....*.
gi 872571191 129 YGGTAL 134
Cdd:cd22192  168 LGNTVL 173
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 63-92 3.47e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 3.47e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 872571191    63 KGRTPLMIATYKNDVKTAKALIEAGADVNI 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-213 4.27e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 144.33  E-value: 4.27e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  30 NMETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 110 LHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRtSVDVNHVNNLGWTALMEAIVLSNGNetqqqVIRLLI 189
Cdd:COG0666  166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENGNLE-----IVKLLL 239

                        170       180
                 ....*....|....*....|....
gi 872571191 190 EHGADVTIPDNDDVTPLEHARAHN 213
Cdd:COG0666  240 EAGADLNAKDKDGLTALLLAAAAG 263
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
24-213 1.55e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 137.78  E-value: 1.55e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  24 VKKEMTNMETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLY 103
Cdd:COG0666   47 LALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 104 AGAEGYLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRtSVDVNHVNNLGWTALMEAIvlSNGNEtqqQ 183
Cdd:COG0666  127 AAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAA--ENGHL---E 200

                        170       180       190
                 ....*....|....*....|....*....|
gi 872571191 184 VIRLLIEHGADVTIPDNDDVTPLEHARAHN 213
Cdd:COG0666  201 IVKLLLEAGADVNAKDNDGKTALDLAAENG 230
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-201 3.47e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.82  E-value: 3.47e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  32 ETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLH 111
Cdd:COG0666  121 ETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLE 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 112 ILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRTSvDVNHVNNLGWTALMEAIVLSNGNETQQQVIRLLIEH 191
Cdd:COG0666  201 IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLA 279

                        170
                 ....*....|
gi 872571191 192 GADVTIPDND 201
Cdd:COG0666  280 AALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-213 1.04e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 109.27  E-value: 1.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  30 NMETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 110 LHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRtSVDVNHVNNLGWTALMEAIvlSNGNEtqqQVIRLLI 189
Cdd:COG0666  100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA-GADVNAQDNDGNTPLHLAA--ANGNL---EIVKLLL 173

                        170       180
                 ....*....|....*....|....
gi 872571191 190 EHGADVTIPDNDDVTPLEHARAHN 213
Cdd:COG0666  174 EAGADVNARDNDGETPLHLAAENG 197
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
30-167 1.16e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.09  E-value: 1.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  30 NMETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:COG0666  152 DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 872571191 110 LHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRTSVDVNHVNNLGWTA 167
Cdd:COG0666  232 LEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03095 PHA03095
ankyrin-like protein; Provisional
 31-208 1.52e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 86.23  E-value: 1.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  31 METSLLAATEKQETNTVI---SLLKKGADINITDSKGRTPL---MIATYKNDVKTAKALIEAGADVNIQDDMKNNPF-LY 103
Cdd:PHA03095  11 MEAALYDYLLNASNVTVEevrRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLY 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 104 AGAEGYLHILKLTIDAGADPSLTNRYGGTALipaseHGYI-------DVINELLtRTSVDVNHVNNLGWTALmeAIVLSN 176
Cdd:PHA03095  91 LYNATTLDVIKLLIKAGADVNAKDKVGRTPL-----HVYLsgfninpKVIRLLL-RKGADVNALDLYGMTPL--AVLLKS 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 872571191 177 GNETqQQVIRLLIEHGADVTIPDNDDVTPLEH 208
Cdd:PHA03095 163 RNAN-VELLRLLIDAGADVYAVDDRFRSLLHH 193
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-209 7.53e-19

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.95  E-value: 7.53e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  33 TSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATY-----KNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAE 107
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNikynlTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISK 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 108 --GYLHILKLTIDAGADPSLTNRYGGTALIPASE--------------HGY-IDVIN--ELLTRTSVDVNHVNNLGWTAL 168
Cdd:PHA03100 117 ksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLEsnkidlkilkllidKGVdINAKNrvNYLLSYGVPINIKDVYGFTPL 196

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 872571191 169 MEAIVLSNGNetqqqVIRLLIEHGADVTIPDNDDVTPLEHA 209
Cdd:PHA03100 197 HYAVYNNNPE-----FVKYLLDLGANPNLVNKYGDTPLHIA 232
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 43-209 1.33e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 83.47  E-value: 1.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  43 ETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKLTIDAGAD 122
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 123 PSLTNRYGGTALIPASEHGYIDVINELLTRTSVDVNHVNNlGWTALMEAIVLSngnetqQQVIRLLIEHgADVTIPDNDD 202
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKN-GFTPLHNAIIHN------RSAIELLINN-ASINDQDIDG 254


                 ....*..
gi 872571191 203 VTPLEHA 209
Cdd:PHA02874 255 STPLHHA 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-213 3.06e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.15  E-value: 3.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  47 VISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKLTIDAGADPSLT 126
Cdd:COG0666    4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 127 NRYGGTALIPASEHGYIDVINELLTRtSVDVNHVNNLGWTALMEAIvlSNGNEtqqQVIRLLIEHGADVTIPDNDDVTPL 206
Cdd:COG0666   84 DDGGNTLLHAAARNGDLEIVKLLLEA-GADVNARDKDGETPLHLAA--YNGNL---EIVKLLLEAGADVNAQDNDGNTPL 157


                 ....*..
gi 872571191 207 EHARAHN 213
Cdd:COG0666  158 HLAAANG 164
PHA03095 PHA03095
ankyrin-like protein; Provisional
 44-213 4.34e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 76.22  E-value: 4.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  44 TNTVISLLKKGADINITDSKGRTPLMIATyKN---DVKTAKALIEAGADVNIQDDMKNNPF----LYAGAegYLHILKLT 116
Cdd:PHA03095 132 PKVIRLLLRKGADVNALDLYGMTPLAVLL-KSrnaNVELLRLLIDAGADVYAVDDRFRSLLhhhlQSFKP--RARIVREL 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 117 IDAGADPSLTNRYGGTALIPASEHG---YIDVINELLtrTSVDVNHVNNLGWTALMEAIVLSNgnetqQQVIRLLIEHGA 193
Cdd:PHA03095 209 IRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLLI--AGISINARNRYGQTPLHYAAVFNN-----PRACRRLIALGA 281

                        170       180
                 ....*....|....*....|
gi 872571191 194 DVTIPDNDDVTPLEHARAHN 213
Cdd:PHA03095 282 DINAVSSDGNTPLSLMVRNN 301
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 31-209 4.91e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 73.07  E-value: 4.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  31 METSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYL 110
Cdd:PHA02874 124 LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 111 HILKLTIDAGADPSLTNRYGGTALIPASEHGYiDVINELLTRTSVDVNHVNnlGWTALMEAIvlsnGNETQQQVIRLLIE 190
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLINNASINDQDID--GSTPLHHAI----NPPCDIDIIDILLY 276

                        170
                 ....*....|....*....
gi 872571191 191 HGADVTIPDNDDVTPLEHA 209
Cdd:PHA02874 277 HKADISIKDNKGENPIDTA 295
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 43-209 2.12e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 71.45  E-value: 2.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  43 ETNTVISLLKKGADINITD-SKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKLTIDAGA 121
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 122 DPSLTNRYGGTAL-IPASEHGYIDVINELLTRtSVDVNHVNN-LGWTALMEAIvlsngneTQQQVIRLLIEHGADVTIPD 199
Cdd:PHA02878 226 STDARDKCGNTPLhISVGYCKDYDILKLLLEH-GVDVNAKSYiLGLTALHSSI-------KSERKLKLLLEYGADINSLN 297

                        170
                 ....*....|
gi 872571191 200 NDDVTPLEHA 209
Cdd:PHA02878 298 SYKLTPLSSA 307
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 30-207 4.57e-14

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 70.67  E-value: 4.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  30 NMETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGY 109
Cdd:PLN03192 524 NMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 110 LHILKLT--IDAGADPSLtnryGGTALIPASEHGYIDVINELLtRTSVDVNHVNNLGWTALMEAIVlsngnETQQQVIRL 187
Cdd:PLN03192 604 HKIFRILyhFASISDPHA----AGDLLCTAAKRNDLTAMKELL-KQGLNVDSEDHQGATALQVAMA-----EDHVDMVRL 673

                        170       180
                 ....*....|....*....|.
gi 872571191 188 LIEHGADVTIPD-NDDVTPLE 207
Cdd:PLN03192 674 LIMNGADVDKANtDDDFSPTE 694
Ank_2 pfam12796
Ankyrin repeats (3 copies);
101-199 1.69e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.98  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  101 FLYAGAEGYLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRtsVDVNHVNNlGWTALMEAIvlSNGNEt 180
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAA--RSGHL- 74

                          90
                  ....*....|....*....
gi 872571191  181 qqQVIRLLIEHGADVTIPD 199
Cdd:pfam12796  75 --EIVKLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-152 1.31e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.17  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  33 TSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHI 112
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 872571191 113 LKLTIDAGADPSLTNRYGG-TALIPASEHGYIDVINELLTR 152
Cdd:PHA02875 184 CKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKR 224
Ank_2 pfam12796
Ankyrin repeats (3 copies);
35-127 1.36e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 1.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191   35 LLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEaGADVNIQDDmKNNPFLYAGAEGYLHILK 114
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 872571191  115 LTIDAGADPSLTN 127
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 35-162 2.25e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 62.38  E-value: 2.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  35 LLAATEKQETNTVIS-LLKKGADINITDSKGRTPLMIATY--KNDVKTAKALIEAGADVN----------------IQDD 95
Cdd:PHA03100 111 LYAISKKSNSYSIVEyLLDNGANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGVDINaknrvnyllsygvpinIKDV 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 872571191  96 MKNNPFLYAGAEGYLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRTSvDVNHVNN 162
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP-SIKTIIE 256
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 53-214 1.40e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.98  E-value: 1.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  53 KGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKLTIDAGADPSLTNryggt 132
Cdd:PHA02874  24 KGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTSILP----- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 133 alIPASEHgyiDVINELLtRTSVDVNHVNNLGWTALMEAIvlSNGNetqQQVIRLLIEHGADVTIPDNDDVTPLEHARAH 212
Cdd:PHA02874  99 --IPCIEK---DMIKTIL-DCGIDVNIKDAELKTFLHYAI--KKGD---LESIKMLFEYGADVNIEDDNGCYPIHIAIKH 167


                 ..
gi 872571191 213 NF 214
Cdd:PHA02874 168 NF 169
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 30-207 3.42e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.85  E-value: 3.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  30 NMETSLLAATEKQETNTVISLLKKGADIN-ITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEG 108
Cdd:PHA02875  67 DIESELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMG 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 109 YLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTrTSVDVNHVNNLGWTALMEAIVLSNgnetQQQVIRLL 188
Cdd:PHA02875 147 DIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCVAALCYAIENN----KIDIVRLF 221

                        170       180
                 ....*....|....*....|..
gi 872571191 189 IEHGAD---VTIPDNDDVTPLE 207
Cdd:PHA02875 222 IKRGADcniMFMIEGEECTILD 243
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 47-213 4.15e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 4.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  47 VISLLKKGADINITDSKGRTPL-MIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGA-EGYLHILKLTIDAGADPS 124
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVN 369

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 125 LTNRYGGTALIPASEHGYIDVINELLTrTSVDVNHVNNLGWTALMEAIVLSNGNETqqqvIRLLIEHGADVTIPDNDDVT 204
Cdd:PHA02876 370 ARDYCDKTPIHYAAVRNNVVIINTLLD-YGADIEALSQKIGTALHFALCGTNPYMS----VKTLIDRGANVNSKNKDLST 444


                 ....*....
gi 872571191 205 PLEHARAHN 213
Cdd:PHA02876 445 PLHYACKKN 453
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 45-129 5.28e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 5.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  45 NTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKLTIDAGADPS 124
Cdd:PHA03100 173 NRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252


                 ....*
gi 872571191 125 LTNRY 129
Cdd:PHA03100 253 TIIET 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 32-206 7.91e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.15  E-value: 7.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  32 ETSL-LAATEKQETNTVISLLKKGADINITDSKGRTPLMIAT----YKNDVKTakaLIEAGADVNIQDDMKNNPFLYAGA 106
Cdd:PHA02876 308 ETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQAStldrNKDIVIT---LLELGANVNARDYCDKTPIHYAAV 384

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 107 EGYLHILKLTIDAGADPSLTNRYGGTALIPA--SEHGYIDVinELLTRTSVDVNHVNNLGWTALMEAIvlsnGNETQQQV 184
Cdd:PHA02876 385 RNNVVIINTLLDYGADIEALSQKIGTALHFAlcGTNPYMSV--KTLIDRGANVNSKNKDLSTPLHYAC----KKNCKLDV 458

                        170       180
                 ....*....|....*....|..
gi 872571191 185 IRLLIEHGADVTIPDNDDVTPL 206
Cdd:PHA02876 459 IEMLLDNGADVNAINIQNQYPL 480
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 33-213 4.36e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.84  E-value: 4.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  33 TSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALI---------------------------- 84
Cdd:PHA02876 180 TPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIdnrsninkndlsllkairnedletslll 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  85 -EAGADVNIQDDMKNNPFLYAGAEGYL-HILKLTIDAGADPSLTNRYGGTALIPASEHGY-IDVINELLTRtSVDVNHVN 161
Cdd:PHA02876 260 yDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIML-GADVNAAD 338

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 872571191 162 NLGWTALMEAIVLSNGNETqqqVIRLLiEHGADVTIPDNDDVTPLEHARAHN 213
Cdd:PHA02876 339 RLYITPLHQASTLDRNKDI---VITLL-ELGANVNARDYCDKTPIHYAAVRN 386
PHA02798 PHA02798
ankyrin-like protein; Provisional
 44-192 7.39e-09

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 55.23  E-value: 7.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  44 TNTVISLLKKGADINITDSKGRTPLM-----IATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLH---ILKL 115
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPLCtilsnIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINnleILLF 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 116 TIDAGADPSLTNRYGGTAL---IPASEHGYIDVInELLTRTSVDVNHVNNLGWTALMEAIVLSNGNETQQQVIRLLIEHG 192
Cdd:PHA02798 131 MIENGADTTLLDKDGFTMLqvyLQSNHHIDIEII-KLLLEKGVDINTHNNKEKYDTLHCYFKYNIDRIDADILKLFVDNG 209
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 50-140 8.25e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 8.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  50 LLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKL---------TIDAG 120
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLlsrhsqchfELGAN 180

                         90       100
                 ....*....|....*....|.
gi 872571191 121 ADP-SLTNRYGGTALIPASEH 140
Cdd:PTZ00322 181 AKPdSFTGKPPSLEDSPISSH 201
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 50-209 1.05e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  50 LLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNI--QDDM--------------------------KNN-P 100
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIiaLDDLsvlecavdsknidtikaiidnrsninKNDlS 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 101 FLYAGAEGYLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRTSVDVNHVNNLGWTALMeaIVLSNGNET 180
Cdd:PHA02876 244 LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLY--LMAKNGYDT 321

                        170       180
                 ....*....|....*....|....*....
gi 872571191 181 QQqvIRLLIEHGADVTIPDNDDVTPLEHA 209
Cdd:PHA02876 322 EN--IRTLIMLGADVNAADRLYITPLHQA 348
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 37-195 2.73e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.45  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  37 AATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYA--GAEGYLHIlK 114
Cdd:PHA02876 348 ASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlcGTNPYMSV-K 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 115 LTIDAGADPSLTNRYGGTALIPASEHGYIDVINELLTRTSVDVNHVNNLGWTALMEAIvlsngneTQQQVIRLLIEHGAD 194
Cdd:PHA02876 427 TLIDRGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQNQYPLLIAL-------EYHGIVNILLHYGAE 499


                 .
gi 872571191 195 V 195
Cdd:PHA02876 500 L 500
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 76-155 8.55e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 8.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  76 DVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVInELLTRTSV 155
Cdd:PTZ00322  94 DAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV-QLLSRHSQ 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-209 1.32e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.11  E-value: 1.32e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 872571191  137 ASEHGYIDVINELLTRtSVDVNHVNNLGWTALMEAIvlSNGNEtqqQVIRLLIEHgADVTIPDNDDvTPLEHA 209
Cdd:pfam12796   4 AAKNGNLELVKLLLEN-GADANLQDKNGRTALHLAA--KNGHL---EIVKLLLEH-ADVNLKDNGR-TALHYA 68
Ank_4 pfam13637
Ankyrin repeats (many copies);
64-115 3.60e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.03  E-value: 3.60e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 872571191   64 GRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKL 115
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKL 52
PHA03095 PHA03095
ankyrin-like protein; Provisional
 47-147 7.27e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.17  E-value: 7.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  47 VISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKLTIDAGADPSLT 126
Cdd:PHA03095 240 VLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETV 319

                         90       100
                 ....*....|....*....|.
gi 872571191 127 NRyggtALIPASEHGYIDVIN 147
Cdd:PHA03095 320 AA----TLNTASVAGGDIPSD 336
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 32-92 1.11e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 1.11e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 872571191  32 ETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNI 92
Cdd:PHA03100 193 FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKT 253
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-84 1.88e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.11  E-value: 1.88e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 872571191   33 TSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALI 84
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 43-195 2.78e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 44.35  E-value: 2.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  43 ETNTVISLLKKGADINiTDSKGRTPLMIATYKNDVKT--AKALIEAGADVNIQDDMK-------NNpfLYAGAEGYLHIL 113
Cdd:PHA02989  15 DKNALEFLLRTGFDVN-EEYRGNSILLLYLKRKDVKIkiVKLLIDNGADVNYKGYIEtplcavlRN--REITSNKIKKIV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 114 KLTIDAGADPSLTNRYGGTALIPASEHGYIDVIN--ELLTRTSVDVNHVNNLGWTALMEaIVLSNGNeTQQQVIRLLIEH 191
Cdd:PHA02989  92 KLLLKFGADINLKTFNGVSPIVCFIYNSNINNCDmlRFLLSKGINVNDVKNSRGYNLLH-MYLESFS-VKKDVIKILLSF 169


                 ....
gi 872571191 192 GADV 195
Cdd:PHA02989 170 GVNL 173
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 63-95 3.18e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 3.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 872571191   63 KGRTPLMIATYK-NDVKTAKALIEAGADVNIQDD 95
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 74-209 6.63e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 6.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  74 KNDVKTAKALIEAGADVNIQDDMKNNPFLYAGAEGYLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELL-TR 152
Cdd:PHA02876 155 QDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIdNR 234

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 872571191 153 TSVDVNHVnnlgwtALMEAIvlsngNETQQQVIRLLIEHGADVTIPDNDDVTPLEHA 209
Cdd:PHA02876 235 SNINKNDL------SLLKAI-----RNEDLETSLLLYDAGFSVNSIDDCKNTPLHHA 280
Ank_4 pfam13637
Ankyrin repeats (many copies);
98-150 7.59e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 7.59e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 872571191   98 NNPFLYAGAEGYLHILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVINELL 150
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
50-104 8.51e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 8.51e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 872571191   50 LLKKG-ADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIQDDMKNNPFLYA 104
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
149-209 9.12e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 9.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 872571191  149 LLTRTSVDVNHVNNLGWTALMEAIvlSNGNetqQQVIRLLIEHGADVTIPDNDDVTPLEHA 209
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAA--KYGA---LEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-134 1.01e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  63 KGRTPLMIATYKNDVKTAKALIEAGADVN--------IQDDMKN------NPFLYAGAEGYLHILKLTIDAGADPSLTNR 128
Cdd:cd22192   88 QGETALHIAVVNQNLNLVRELIARGADVVspratgtfFRPGPKNliyygeHPLSFAACVGNEEIVRLLIEHGADIRAQDS 167


                 ....*.
gi 872571191 129 YGGTAL 134
Cdd:cd22192  168 LGNTVL 173
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 63-92 3.47e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 3.47e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 872571191    63 KGRTPLMIATYKNDVKTAKALIEAGADVNI 92
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 32-166 4.26e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 40.19  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  32 ETSLLAATEKQETNTVIS--LLKKGADIN-ITDSKGRTPL-MIATYKNDV--KTAKALIEAGADVNIQDDMKNNPF--LY 103
Cdd:PHA02859  52 ETPIFSCLEKDKVNVEILkfLIENGADVNfKTRDNNLSALhHYLSFNKNVepEILKILIDSGSSITEEDEDGKNLLhmYM 131

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 872571191 104 AGAEGYLHILKLTIDAGADPSLTNRYGGTALipaseHGYI-----DVINELLTRTSVDVNHVNNLGWT 166
Cdd:PHA02859 132 CNFNVRINVIKLLIDSGVSFLNKDFDNNNIL-----YSYIlfhsdKKIFDFLTSLGIDINETNKSGYN 194
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 29-146 4.36e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  29 TNMETSLLAATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEAGADVNIqddMKNNP----FLYA 104
Cdd:PHA02875 133 TDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDY---FGKNGcvaaLCYA 209

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 872571191 105 GAEGYLHILKLTIDAGADPSLtnryggTALIPASEHGYIDVI 146
Cdd:PHA02875 210 IENNKIDIVRLFIKRGADCNI------MFMIEGEECTILDMI 245
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 38-212 7.19e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.25  E-value: 7.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  38 ATEKQETNTVISLLKKGADINITDSKGRTPLMIATYKNDVKTAKALIEagadVNIQDDMKNNPFLYAGAEGY--LHILKL 115
Cdd:PHA02878  44 AVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIR----SINKCSVFYTLVAIKDAFNNrnVEIFKI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 116 TidagadpsLTNRYGG---TALIPASEHGYIDVINELLTRT----SVDVNHVN-NLGWTALMEAivlsnGNETQQQVIRL 187
Cdd:PHA02878 120 I--------LTNRYKNiqtIDLVYIDKKSKDDIIEAEITKLllsyGADINMKDrHKGNTALHYA-----TENKDQRLTEL 186

                        170       180
                 ....*....|....*....|....*
gi 872571191 188 LIEHGADVTIPDNDDVTPLEHARAH 212
Cdd:PHA02878 187 LLSYGANVNIPDKTNNSPLHHAVKH 211
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 164-200 1.01e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 1.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 872571191  164 GWTALMEAIVLSNgnetQQQVIRLLIEHGADVTIPDN 200
Cdd:pfam00023   2 GNTPLHLAAGRRG----NLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 183-214 1.13e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 872571191 183 QVIRLLIEHGADVTIPDNDDVTPLEHARAHNF 214
Cdd:PTZ00322 129 QVVRVLLEFGADPTLLDKDGKTPLELAEENGF 160
Ank_4 pfam13637
Ankyrin repeats (many copies);
130-189 1.41e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 1.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  130 GGTALIPASEHGYIDVINELLtRTSVDVNHVNNLGWTALMEAIvlSNGNEtqqQVIRLLI 189
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAA--SNGNV---EVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 22-115 2.28e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.46  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  22 QEVKKEMTNMETSLLAATEKQETNTVISLLKKGADIN------ITDSKGRT--------PLMIATYKNDVKTAKALIEAG 87
Cdd:cd22192   80 EPMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPKnliyygehPLSFAACVGNEEIVRLLIEHG 159

                         90       100
                 ....*....|....*....|....*...
gi 872571191  88 ADVNIQDDMKNNPflyagaegyLHILKL 115
Cdd:cd22192  160 ADIRAQDSLGNTV---------LHILVL 178
PHA02798 PHA02798
ankyrin-like protein; Provisional
 41-213 2.84e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 38.28  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  41 KQETNTVISLLKKGADINITDSKGRTP---LMIATYKNDVKTAKALIEAGADVNIQDDMKNNP---FLYAGAEGYLHILK 114
Cdd:PHA02798  86 KHMLDIVKILIENGADINKKNSDGETPlycLLSNGYINNLEILLFMIENGADTTLLDKDGFTMlqvYLQSNHHIDIEIIK 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191 115 LTIDAGAD-PSLTNRYGGTALipaseHGY----IDVINELLTRTSVD----VNHVNNLGWTALMEAIV--LSNGNETQQQ 183
Cdd:PHA02798 166 LLLEKGVDiNTHNNKEKYDTL-----HCYfkynIDRIDADILKLFVDngfiINKENKSHKKKFMEYLNslLYDNKRFKKN 240

                        170       180       190
                 ....*....|....*....|....*....|
gi 872571191 184 VIRLLIEHgADVTIPDNDDVTPLEHARAHN 213
Cdd:PHA02798 241 ILDFIFSY-IDINQVDELGFNPLYYSVSHN 269
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 43-172 3.59e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 37.97  E-value: 3.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  43 ETNTVISLLKKGADINITDSKGRTPL---MIATYKNdVKTAKALIEAGADVNIQDDMKNNPFlyagaegYLHILKLTIDA 119
Cdd:PHA02716 296 DISVVYSFLQPGVKLHYKDSAGRTCLhqyILRHNIS-TDIIKLLHEYGNDLNEPDNIGNTVL-------HTYLSMLSVVN 367

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 872571191 120 GADPSLTNRYGgtalipasehgyIDVINELLtRTSVDVNHVNNLGWTALMEAI 172
Cdd:PHA02716 368 ILDPETDNDIR------------LDVIQCLI-SLGADITAVNCLGYTPLTSYI 407
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 63-92 3.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 33.77  E-value: 3.96e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 872571191   63 KGRTPLMIATYKNDVKTAKALIEAGADVNI 92
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 31-147 5.78e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 37.41  E-value: 5.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872571191  31 METSLLAA------TEKQETNTVISLLKKGADINITDSKGRTPLMIATYK---NDVKTAKALIEAGADVNIQDDMKNNPF 101
Cdd:PHA02989  69 IETPLCAVlrnreiTSNKIKKIVKLLLKFGADINLKTFNGVSPIVCFIYNsniNNCDMLRFLLSKGINVNDVKNSRGYNL 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 872571191 102 LYAGAEGYL---HILKLTIDAGADPSLTNRYGGTALIPASEHGYIDVIN 147
Cdd:PHA02989 149 LHMYLESFSvkkDVIKILLSFGVNLFEKTSLYGLTPMNIYLRNDIDVIS 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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