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Conserved domains on  [gi|872706710|ref|WP_048558101|]
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MULTISPECIES: hypothetical protein [Bacillus cereus group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 2-75 6.19e-03

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member smart00268:

Pssm-ID: 483947 [Multi-domain]  Cd Length: 373  Bit Score: 33.77  E-value: 6.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872706710     2 YTVKERSRTFIERFFEEKHIPSDIFVI------KHKGLThvieNGIVIDM------IkqAPIEEQKVIEKQIRKIDFYNR 69
Cdd:smart00268 105 MNPKSNREKILEIMFETFNFPALYIAIqavlslYASGRT----TGLVIDSgdgvthV--VPVVDGYVLPHAIKRIDIAGR 178


                   ....*.
gi 872706710    70 DINHYL 75
Cdd:smart00268 179 DITDYL 184
 
Name Accession Description Interval E-value
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 2-75 6.19e-03

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 33.77  E-value: 6.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872706710     2 YTVKERSRTFIERFFEEKHIPSDIFVI------KHKGLThvieNGIVIDM------IkqAPIEEQKVIEKQIRKIDFYNR 69
Cdd:smart00268 105 MNPKSNREKILEIMFETFNFPALYIAIqavlslYASGRT----TGLVIDSgdgvthV--VPVVDGYVLPHAIKRIDIAGR 178


                   ....*.
gi 872706710    70 DINHYL 75
Cdd:smart00268 179 DITDYL 184
 
Name Accession Description Interval E-value
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 2-75 6.19e-03

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 33.77  E-value: 6.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 872706710     2 YTVKERSRTFIERFFEEKHIPSDIFVI------KHKGLThvieNGIVIDM------IkqAPIEEQKVIEKQIRKIDFYNR 69
Cdd:smart00268 105 MNPKSNREKILEIMFETFNFPALYIAIqavlslYASGRT----TGLVIDSgdgvthV--VPVVDGYVLPHAIKRIDIAGR 178


                   ....*.
gi 872706710    70 DINHYL 75
Cdd:smart00268 179 DITDYL 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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