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Conserved domains on  [gi|873897957|ref|WP_048604398|]
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winged helix-turn-helix transcriptional regulator [Enterococcus massiliensis]

Protein Classification

ROK family transcriptional regulator( domain architecture ID 20682363)

NagC/ROK (Repressor, ORF, Kinase) family transcriptional regulator is involved in carbohydrate-dependent transcriptional control; contains a DNA-binding helix-turn-helix (HTH) domain

CATH:  3.30.420.40|1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0005524|GO:0003677
PubMed:  20512568|17979299|7952186|15808743|2644244|8831795|7781919|8800467
SCOP:  3000034|3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 108-320 1.95e-09

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


:

Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 57.09  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 108 NITDGIDSLKNNLQELVEQIKDNGIDVELIRSWAIIVPGIISLENNEIIYSKPLNLKHvsvNSDL--FLHKVVN-NIYVF 184
Cdd:cd23763   30 PAEEGPEAVLDRIAELIEELLAEAGVRERILGIGIGVPGPVDPETGIVLFAPNLPWWK---NVPLreLLEERLGlPVVVE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 185 QDSDAYLLG---------YKPLkmnnrtAFLLLHEGLGFSLINNNELMK--EQVGGlEIGHTIFIDskgrltklgdifrn 253
Cdd:cd23763  107 NDANAAALGeawfgagrgVRNF------VYITLGTGIGGGIIIDGKLYRgaNGAAG-EIGHITVLE-------------- 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 873897957 254 kqiiikgedEATRkkALAVCLINIINLFNPDLLLVGGD--NVNDLMDDKLINSVEEEALLPYMEATEIK 320
Cdd:cd23763  166 ---------EAAR--YLGIGLANLINLLNPELIVLGGGvaEAGDLLLEPIREAVRRRALPPLRRRVRIV 223
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
14-51 1.11e-04

Winged helix-turn-helix DNA-binding;


:

Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 38.95  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 873897957   14 VLRSLLKNESCSQNELAHNTGLSIPSVGKILKELIEKG 51
Cdd:pfam13412   6 ILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEG 43
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 108-320 1.95e-09

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 57.09  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 108 NITDGIDSLKNNLQELVEQIKDNGIDVELIRSWAIIVPGIISLENNEIIYSKPLNLKHvsvNSDL--FLHKVVN-NIYVF 184
Cdd:cd23763   30 PAEEGPEAVLDRIAELIEELLAEAGVRERILGIGIGVPGPVDPETGIVLFAPNLPWWK---NVPLreLLEERLGlPVVVE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 185 QDSDAYLLG---------YKPLkmnnrtAFLLLHEGLGFSLINNNELMK--EQVGGlEIGHTIFIDskgrltklgdifrn 253
Cdd:cd23763  107 NDANAAALGeawfgagrgVRNF------VYITLGTGIGGGIIIDGKLYRgaNGAAG-EIGHITVLE-------------- 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 873897957 254 kqiiikgedEATRkkALAVCLINIINLFNPDLLLVGGD--NVNDLMDDKLINSVEEEALLPYMEATEIK 320
Cdd:cd23763  166 ---------EAAR--YLGIGLANLINLLNPELIVLGGGvaEAGDLLLEPIREAVRRRALPPLRRRVRIV 223
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 108-320 3.81e-08

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 54.13  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 108 NITDGIDSLKNNLQELVEQ-IKDNGIDVELIRSWAIIVPGIISLENNEIIYSKPL-NLKHVSVNSDLflHKVVN-NIYVF 184
Cdd:COG1940   37 PAGAGPEAVLEAIAELIEElLAEAGISRGRILGIGIGVPGPVDPETGVVLNAPNLpGWRGVPLAELL--EERLGlPVFVE 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 185 QDSDAYLLG---YKPLKMNNRTAFLLLHEGLGFSLINNNELMKEQVG-GLEIGHTIfIDSKGRLTKLG------------ 248
Cdd:COG1940  115 NDANAAALAeawFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGnAGEIGHMP-VDPDGPLCGCGnrgcletyasgp 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 249 ------------------DIFRNKQiiiKGEDEATR-----KKALAVCLINIINLFNPDLLLVGGD--NVNDLMDDKLIN 303
Cdd:COG1940  194 allrrarelggaekltaeELFAAAR---AGDPLALEvldeaARYLGIGLANLINLLDPEVIVLGGGvsAAGDLLLEPIRE 270

                        250
                 ....*....|....*..
gi 873897957 304 SVEEEALLPYMEATEIK 320
Cdd:COG1940  271 ALAKYALPPAREDPRIV 287
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
14-51 1.11e-04

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 38.95  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 873897957   14 VLRSLLKNESCSQNELAHNTGLSIPSVGKILKELIEKG 51
Cdd:pfam13412   6 ILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEG 43
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-51 8.09e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 39.18  E-value: 8.09e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 873897957  14 VLRSLLKNESCSQNELAHNTGLSIPSVGKILKELIEKG 51
Cdd:COG1846   43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80
 
Name Accession Description Interval E-value
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 108-320 1.95e-09

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 57.09  E-value: 1.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 108 NITDGIDSLKNNLQELVEQIKDNGIDVELIRSWAIIVPGIISLENNEIIYSKPLNLKHvsvNSDL--FLHKVVN-NIYVF 184
Cdd:cd23763   30 PAEEGPEAVLDRIAELIEELLAEAGVRERILGIGIGVPGPVDPETGIVLFAPNLPWWK---NVPLreLLEERLGlPVVVE 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 185 QDSDAYLLG---------YKPLkmnnrtAFLLLHEGLGFSLINNNELMK--EQVGGlEIGHTIFIDskgrltklgdifrn 253
Cdd:cd23763  107 NDANAAALGeawfgagrgVRNF------VYITLGTGIGGGIIIDGKLYRgaNGAAG-EIGHITVLE-------------- 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 873897957 254 kqiiikgedEATRkkALAVCLINIINLFNPDLLLVGGD--NVNDLMDDKLINSVEEEALLPYMEATEIK 320
Cdd:cd23763  166 ---------EAAR--YLGIGLANLINLLNPELIVLGGGvaEAGDLLLEPIREAVRRRALPPLRRRVRIV 223
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 110-335 1.63e-08

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 55.26  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 110 TDGIDSLKNNLQELVEQIKDNGIDvelIRSWAIIVPGIISLENNEIIYSKPLNLKHVSVNSDLFLHKvvnNIYVFQDSDA 189
Cdd:cd24076   39 DEVLAQLAALIREALAAAPDSPLG---ILGIGVGVPGLVDSEDGVVLLAPNLGWRDVPLRDLLEEAL---GVPVFVDNEA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 190 YL--LGYKPL---KMNNRTAFLLLHEGLGFSLINNNELMKeQVGGL--EIGHTI------------------------FI 238
Cdd:cd24076  113 NAaaLAEKRFgagRGVSDLVYLSAGVGIGAGIILDGELYR-GASGFagEIGHMTvdpdgppcscgnrgcwetyaseraLL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 239 DSKGRLTKLGDIFRNKQII--IKGEDEATRK------KALAVCLINIINLFNPDLLLVGGD--NVNDLMDDKLINSVEEE 308
Cdd:cd24076  192 RAAGRLGAGGEPLSLAELVeaARAGDPAALAaleevgEYLGIGLANLVNTFNPELVVLGGAlaPLGPWLLPPLRAEVARR 271

                        250       260       270
                 ....*....|....*....|....*....|..
gi 873897957 309 ALLPYMEATEIK-----EISCSRtGAIRGVID 335
Cdd:cd24076  272 ALPAPARDVRIVvsrlgEDAAAL-GAAALAID 302
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 108-320 3.81e-08

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 54.13  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 108 NITDGIDSLKNNLQELVEQ-IKDNGIDVELIRSWAIIVPGIISLENNEIIYSKPL-NLKHVSVNSDLflHKVVN-NIYVF 184
Cdd:COG1940   37 PAGAGPEAVLEAIAELIEElLAEAGISRGRILGIGIGVPGPVDPETGVVLNAPNLpGWRGVPLAELL--EERLGlPVFVE 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 185 QDSDAYLLG---YKPLKMNNRTAFLLLHEGLGFSLINNNELMKEQVG-GLEIGHTIfIDSKGRLTKLG------------ 248
Cdd:COG1940  115 NDANAAALAeawFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANGnAGEIGHMP-VDPDGPLCGCGnrgcletyasgp 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 249 ------------------DIFRNKQiiiKGEDEATR-----KKALAVCLINIINLFNPDLLLVGGD--NVNDLMDDKLIN 303
Cdd:COG1940  194 allrrarelggaekltaeELFAAAR---AGDPLALEvldeaARYLGIGLANLINLLDPEVIVLGGGvsAAGDLLLEPIRE 270

                        250
                 ....*....|....*..
gi 873897957 304 SVEEEALLPYMEATEIK 320
Cdd:COG1940  271 ALAKYALPPAREDPRIV 287
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 113-290 3.21e-07

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 51.13  E-value: 3.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 113 IDSLKNNLQELVEQIKDNGidveLIRSWAIIVPGIISLENNEIIYSKPLNLKHVSVNSdlFLHKVVN-NIYVFQDSDAYL 191
Cdd:cd24071   42 IELIAENIKKLIKNKHVEK----KLLGIGIAVSGLVDSKKGIVIRSTILGWENVELKK--ILKEKFKiPVFIDNDVNSFA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 192 LGYKPL---KMNNRTAFLLLHEGLGFSLINNNELMKEQVGGL-EIGHTIfIDSKGRLTKLG-----------DIFRN--K 254
Cdd:cd24071  116 LAELWKgkgKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAgEIGHMT-IQPDGRKCYCGqkgcleayasfEALVNeiK 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 873897957 255 QIIIKG----------------------EDEATRK------KALAVCLINIINLFNPDLLLVGG 290
Cdd:cd24071  195 ELTESYplsllkeledfeiekvreaaeeGDSVATElfkkagEYLGIGIKNLINIFNPEAIIIGG 258
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
14-51 1.11e-04

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 38.95  E-value: 1.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 873897957   14 VLRSLLKNESCSQNELAHNTGLSIPSVGKILKELIEKG 51
Cdd:pfam13412   6 ILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEG 43
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 117-320 2.06e-04

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 42.56  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 117 KNNLQELVEQIKDNgID--VELIRSWAIIVPGIISLENNEIIY-SKPLNLKHVSVNSDLflHKVVN-NIYVFQDSDAYLL 192
Cdd:cd24152   33 KDSLEEFLDYIKKI-IKryDEEIDGIAISAPGVIDPETGIIYGgGALPYLKGFNLKEEL--EERCNlPVSIENDAKCAAL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 193 G---YKPLKMNNRTAFLLLHEGLGFSLINNNELMK--EQVGGlEIGHTIFIDSKGRLTKLGDI-----------FRNKQI 256
Cdd:cd24152  110 AelwLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRgsHFFAG-EFSYLLTDDDDKDLLFFSGLasmfglvkrynKAKGLE 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 257 IIKGE---------DEATRK------KALAVCLINIINLFNPDLLLVGGD-NVNDLMDDKLINSVEE--EALLPYMEATE 318
Cdd:cd24152  189 PLDGEeifekyakgDEAAKKildeyiRNLAKLIYNIQYILDPEVIVIGGGiSEQPLFIEDLKKEVNEilANRPGSIPKPE 268


                 ..
gi 873897957 319 IK 320
Cdd:cd24152  269 IK 270
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 268-320 6.16e-04

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 41.00  E-value: 6.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 873897957 268 KALAVCLINIINLFNPDLLLVGG--DNVNDLMDDKLINSVEEEALLPYMEATEIK 320
Cdd:cd24068  224 EDLATGLANLVHIFDPEVIVIGGgiSAQGELFLEELREELRKLLMPPLLDATKIE 278
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 13-51 7.70e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.18  E-value: 7.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 873897957   13 LVLRSLLKNESCSQNELAHNTGLSIPSVGKILKELIEKG 51
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKG 47
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
14-51 8.09e-04

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 39.18  E-value: 8.09e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 873897957  14 VLRSLLKNESCSQNELAHNTGLSIPSVGKILKELIEKG 51
Cdd:COG1846   43 VLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 104-286 3.78e-03

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 38.68  E-value: 3.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 104 VELKNITDGIDSLKNNLQELVEQIKDNGIDVELIrswAIIVPGIISleNNEIIYSKPLNLKHVSVNSDLflhKVVNNIYV 183
Cdd:cd24077   32 LLDISFENILEILKSIIQELISQAPKTPYGLVGI---GIGIHGIVD--ENEIIFTPYYDLEDIDLKEKL---EEKFNVPV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 184 FQDSDAYLLGYKPLKMNNRTAFLL---LHEGLGFSLINNNELMKEQVG--GlEIGHTIfIDSKGRLTKLG---------- 248
Cdd:cd24077  104 YLENEANLSALAERTFSEDYDNLIsisIHSGIGAGIIINNQLYRGYNGfaG-EIGHMI-IVPNGKPCPCGnkgcleqyas 181

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 873897957 249 -----------------DIFRNKQIIIKGEDEATRK-----KALAVCLINIINLFNPDLL 286
Cdd:cd24077  182 ekallkelsekkgletlTFDDLIQLYNEGDPEALELidqfiKYLAIGINNIINTFNPEII 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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