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Conserved domains on  [gi|873903935|ref|WP_048610268|]
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MULTISPECIES: choline dehydrogenase [Vibrio]

Protein Classification

choline dehydrogenase( domain architecture ID 11479750)

oxygen-dependent choline dehydrogenase catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate

EC:  1.1.99.1
Gene Ontology:  GO:0008812

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 1-567 0e+00

choline dehydrogenase; Validated


:

Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1081.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEQEPGLDGRELH 78
Cdd:PRK02106   2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDyrWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  79 CPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMElNPL 157
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELpGLEGWSYADCLPYFKKAETRDGGEDDYRGGDGPLSVTRGKPGT-NPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 158 YQAFIDAGKDAGYPETNDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEaqdsngqsGL 237
Cdd:PRK02106 161 FQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFE--------GK 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 238 KAVGVEFEKSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSGVGENLQDHLEVYFQYHCNEPI 317
Cdd:PRK02106 233 RAVGVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYECKQPV 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 318 TLNSKLGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVGPNKPE 397
Cdd:PRK02106 313 SLYPALKWWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVGPMRSP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 398 SRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRGEEIQPGLSVTSDEAIDEWVKQNVESAY 477
Cdd:PRK02106 393 SRGSVKLKSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREHAETAY 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 478 HPSCGCKMGAddDPMAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERASDLILGKPMLKEQDVPVWIAPEW 557
Cdd:PRK02106 473 HPSCTCKMGT--DPMAVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYYVAGDW 550

                        570
                 ....*....|
gi 873903935 558 QEKQRINKPV 567
Cdd:PRK02106 551 PVRQRAQRPR 560
 
Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 1-567 0e+00

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1081.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEQEPGLDGRELH 78
Cdd:PRK02106   2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDyrWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  79 CPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMElNPL 157
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELpGLEGWSYADCLPYFKKAETRDGGEDDYRGGDGPLSVTRGKPGT-NPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 158 YQAFIDAGKDAGYPETNDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEaqdsngqsGL 237
Cdd:PRK02106 161 FQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFE--------GK 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 238 KAVGVEFEKSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSGVGENLQDHLEVYFQYHCNEPI 317
Cdd:PRK02106 233 RAVGVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYECKQPV 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 318 TLNSKLGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVGPNKPE 397
Cdd:PRK02106 313 SLYPALKWWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVGPMRSP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 398 SRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRGEEIQPGLSVTSDEAIDEWVKQNVESAY 477
Cdd:PRK02106 393 SRGSVKLKSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREHAETAY 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 478 HPSCGCKMGAddDPMAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERASDLILGKPMLKEQDVPVWIAPEW 557
Cdd:PRK02106 473 HPSCTCKMGT--DPMAVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYYVAGDW 550

                        570
                 ....*....|
gi 873903935 558 QEKQRINKPV 567
Cdd:PRK02106 551 PVRQRAQRPR 560
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 1-541 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 770.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTDKSIFIQMPTALSYPMNTEKYAWQFETEQEPGLDGRELHCP 80
Cdd:COG2303    1 MLEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLIRMPAGYAKLLGNPRYDWRYETEPQPGLNGRRLYWP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  81 RGKVLGGSSSINGMVYVRGHACDFDQWEEEGAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMelNPLYQA 160
Cdd:COG2303   81 RGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGADAYHGRSGPLPVSDPPLP--NPLSDA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 161 FIDAGKDAGYPETNDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEaqdsngqsGLKAV 240
Cdd:COG2303  159 FIEAAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFD--------GGRAT 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 241 GVEFEKSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSGVGENLQDHLEVYFQYHCNEPITLN 320
Cdd:COG2303  231 GVEYRDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTLN 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 321 SKLglvSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRY-DGQAAF-DGHGFQVHVGPNKPES 398
Cdd:COG2303  311 KSL---RKARIGLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPrWGKKALhDGHGFTAHVEQLRPES 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 399 RGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRGEEIQPGLSVTSDEAiDEWVKQNVESAYH 478
Cdd:COG2303  388 RGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEE-LAFIRARAYTIYH 466

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 873903935 479 PSCGCKMGAddDPMAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERASDLILGK 541
Cdd:COG2303  467 PVGTCRMGT--DPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGD 527
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 6-544 0e+00

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 723.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935    6 DYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEQEPGLDGRELHCPRGK 83
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGSDypWDLLIQMPAALAYPAGNKRYNWIYETEPEPHMNNRRVGHARGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   84 VLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMelNPLYQAFI 162
Cdd:TIGR01810  81 VLGGSSSINGMIYQRGNPMDYEKWAKPeGMESWDYADCLPYYKRLETTFGGEKPYRGHDGPIKVRRGPAD--NPLFQAFI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  163 DAGKDAGYPETNDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEaqdsngqsGLKAVGV 242
Cdd:TIGR01810 159 EAGVEAGYNKTPDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAMKRPNLEVQTRAFVTKINFE--------GNRATGV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  243 EFEKSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSGVGENLQDHLEVYFQYHCNEPITLNSK 322
Cdd:TIGR01810 231 EFKKGGRKEHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLPGVGENLQDHLEVYVQHACKQPVSLYPS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  323 LGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVGPNKPESRGTV 402
Cdd:TIGR01810 311 LNWLKQPFIGAQWLFGRKGAGASNHFEGGGFVRSNDDVDYPNIQYHFLPVAIRYDGTKAPKAHGFQVHVGPMYSNSRGHV 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  403 AITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRGEEIQPGLSVTSDEAIDEWVKQNVESAYHPSCG 482
Cdd:TIGR01810 391 KIKSKDPFEKPEIVFNYMSHEEDWREFREAIRVTREILKQKALDPYRGGEISPGPEVQTDEEIDEFVRRHGETALHPCGT 470

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 873903935  483 CKMGADDDPMAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERASDLILGKPML 544
Cdd:TIGR01810 471 CKMGPASDEMSVVDPETRVHGMEGLRVVDASIMPRITNGNLNAPVIMMGEKAADIIRGKKPL 532
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 73-306 1.99e-55

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 186.33  E-value: 1.99e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   73 DGRELHCPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAEswnkggdeyrgdnGPVGTCNGND 151
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWASEfGLEGWGYDDYLPYMDKVE-------------GPLGVTTKGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  152 mELNPLYQAFIDAGKDAGYPETN---DYNGYQQEGFGtmHMTVDKGVRASTSNAYLRRALKRsNLTLKKGIVARRFLLEa 228
Cdd:pfam00732  82 -EESPLNQALLKAAEELGYPVEAvprNSNGCHYCGFC--GLGCPTGAKQSTARTWLRPALER-NLRILTGAKAEKIIIL- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  229 qdsngQSGLKAVGVEFE--KSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKavlekagvevKHelsGVGENLQDHLE 306
Cdd:pfam00732 157 -----GRGGRAVGVEARdgGGGIKRLITAAKEVVVAAGALNTPPLLLRSGLGKN----------PH---PVGKNLQLHPV 218
 
Name Accession Description Interval E-value
PRK02106 PRK02106
choline dehydrogenase; Validated
 1-567 0e+00

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 1081.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEQEPGLDGRELH 78
Cdd:PRK02106   2 TTMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGPDyrWDFFIQMPAALAFPLQGKRYNWAYETEPEPHMNNRRME 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  79 CPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMElNPL 157
Cdd:PRK02106  82 CPRGKVLGGSSSINGMVYIRGNAMDYDNWAELpGLEGWSYADCLPYFKKAETRDGGEDDYRGGDGPLSVTRGKPGT-NPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 158 YQAFIDAGKDAGYPETNDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEaqdsngqsGL 237
Cdd:PRK02106 161 FQAFVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPALKRPNLTIVTHALTDRILFE--------GK 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 238 KAVGVEFEKSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSGVGENLQDHLEVYFQYHCNEPI 317
Cdd:PRK02106 233 RAVGVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPGVGENLQDHLEVYIQYECKQPV 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 318 TLNSKLGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVGPNKPE 397
Cdd:PRK02106 313 SLYPALKWWNKPKIGAEWLFTGTGLGASNHFEAGGFIRSRAGVDWPNIQYHFLPVAIRYDGSNAVKGHGFQAHVGPMRSP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 398 SRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRGEEIQPGLSVTSDEAIDEWVKQNVESAY 477
Cdd:PRK02106 393 SRGSVKLKSADPRAHPSILFNYMSTEQDWREFRDAIRLTREIMAQPALDPYRGREISPGADVQTDEEIDAFVREHAETAY 472

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 478 HPSCGCKMGAddDPMAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERASDLILGKPMLKEQDVPVWIAPEW 557
Cdd:PRK02106 473 HPSCTCKMGT--DPMAVVDPEGRVHGVEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIRGRTPLARSNAPYYVAGDW 550

                        570
                 ....*....|
gi 873903935 558 QEKQRINKPV 567
Cdd:PRK02106 551 PVRQRAQRPR 560
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 1-541 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 770.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTDKSIFIQMPTALSYPMNTEKYAWQFETEQEPGLDGRELHCP 80
Cdd:COG2303    1 MLEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLIRMPAGYAKLLGNPRYDWRYETEPQPGLNGRRLYWP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  81 RGKVLGGSSSINGMVYVRGHACDFDQWEEEGAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMelNPLYQA 160
Cdd:COG2303   81 RGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGADAYHGRSGPLPVSDPPLP--NPLSDA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 161 FIDAGKDAGYPETNDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEaqdsngqsGLKAV 240
Cdd:COG2303  159 FIEAAEELGIPRADDFNGGACEGCGFCQVTCRNGARWSAARAYLPPALKRPNLTVRTGALVTRILFD--------GGRAT 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 241 GVEFEKSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSGVGENLQDHLEVYFQYHCNEPITLN 320
Cdd:COG2303  231 GVEYRDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLPGVGRNLQDHLEVSVVFRFKEPVTLN 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 321 SKLglvSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRY-DGQAAF-DGHGFQVHVGPNKPES 398
Cdd:COG2303  311 KSL---RKARIGLQYLLTRSGPLTSNVAEAGGFFRSDPGLERPDLQFHFLPLGLTPrWGKKALhDGHGFTAHVEQLRPES 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 399 RGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRGEEIQPGLSVTSDEAiDEWVKQNVESAYH 478
Cdd:COG2303  388 RGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPYRGEEILPGPDVQSDEE-LAFIRARAYTIYH 466

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 873903935 479 PSCGCKMGAddDPMAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERASDLILGK 541
Cdd:COG2303  467 PVGTCRMGT--DPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAADMILGD 527
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 6-544 0e+00

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 723.98  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935    6 DYIIVGAGSAGCVLADRLTESGEHSVLLLEAGGTD--KSIFIQMPTALSYPMNTEKYAWQFETEQEPGLDGRELHCPRGK 83
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGSDypWDLLIQMPAALAYPAGNKRYNWIYETEPEPHMNNRRVGHARGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   84 VLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTCNGNDMelNPLYQAFI 162
Cdd:TIGR01810  81 VLGGSSSINGMIYQRGNPMDYEKWAKPeGMESWDYADCLPYYKRLETTFGGEKPYRGHDGPIKVRRGPAD--NPLFQAFI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  163 DAGKDAGYPETNDYNGYQQEGFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLEaqdsngqsGLKAVGV 242
Cdd:TIGR01810 159 EAGVEAGYNKTPDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAMKRPNLEVQTRAFVTKINFE--------GNRATGV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  243 EFEKSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSGVGENLQDHLEVYFQYHCNEPITLNSK 322
Cdd:TIGR01810 231 EFKKGGRKEHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLPGVGENLQDHLEVYVQHACKQPVSLYPS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  323 LGLVSKGMIGAEWILTRKGLGATNHFESCAFIRSRKGLKWPNIQYHFLPAAMRYDGQAAFDGHGFQVHVGPNKPESRGTV 402
Cdd:TIGR01810 311 LNWLKQPFIGAQWLFGRKGAGASNHFEGGGFVRSNDDVDYPNIQYHFLPVAIRYDGTKAPKAHGFQVHVGPMYSNSRGHV 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  403 AITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRGEEIQPGLSVTSDEAIDEWVKQNVESAYHPSCG 482
Cdd:TIGR01810 391 KIKSKDPFEKPEIVFNYMSHEEDWREFREAIRVTREILKQKALDPYRGGEISPGPEVQTDEEIDEFVRRHGETALHPCGT 470

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 873903935  483 CKMGADDDPMAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERASDLILGKPML 544
Cdd:TIGR01810 471 CKMGPASDEMSVVDPETRVHGMEGLRVVDASIMPRITNGNLNAPVIMMGEKAADIIRGKKPL 532
Rv0697 TIGR03970
dehydrogenase, Rv0697 family; This model describes a set of dehydrogenases belonging to the ...
 6-539 1.75e-97

dehydrogenase, Rv0697 family; This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function.


Pssm-ID: 274888 [Multi-domain]  Cd Length: 487  Bit Score: 305.20  E-value: 1.75e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935    6 DYIIVGAGSAGCVLADRLTESGEHSVLLLEAG---GTDKSIFIQMPTALSYPMN-TEKYAWQFETE--QEPGldgRELHC 79
Cdd:TIGR03970   2 DVLIVGAGSAGSVLAARLSEDPSCTVTVLEAGpgyRDPSRLPAQLTDGLRLPIGpASPVVWRYGVEltDGPR---RASQI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   80 PRGKVLGGSSSINGMVYVRGHACDFDQWeeeGAAGWNYQACLPYFRRAESWNKGGDEYRGDNGPVGTcnGNDMELNPLYQ 159
Cdd:TIGR03970  79 VRGRVLGGSGAVNGGYFCRALPADFDAW---PIPGWSWDDVLPHFRAIETDLDFDGPLHGTAGPIPV--RRTAELDGISA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  160 AFIDAGKDAGYPETNDYNGYQQE---GFGTMHMTVDKGVRASTSNAYLRRALKRSNLTLKKGIVARRFLLeaqdsngqSG 236
Cdd:TIGR03970 154 AFVAAALGAGFGWIADLNGSGPGlpgGVGAVPLNVDGGRRVSTAVAYLLPALKRPNLTVEADTRVVRILF--------SG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  237 LKAVGVEFEKSGNTQVAVANKeVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSgVGENLQDHLEVYFQYHCNEP 316
Cdd:TIGR03970 226 TRAVGVEVLGDGGPRTLRADR-VVLCAGAVESAHLLLLSGIGPAEQLRAAGIAVVLDLP-VGSDFVDHPEWVLPYRWRPT 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  317 ITLNSKLGLVskgmigaEWILTrkglgaTNHFE----SCAFIRSRKGLkwPNIQYHFLPAAMRydgqaafdghgfqvhvg 392
Cdd:TIGR03970 304 HDRPPTSPVL-------ETVLN------TADIEirpyTAGFTALVPGS--PRDDPHLGVALMR----------------- 351

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  393 pnkPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPamdayrgeEIQPGLSVTSDEAIDEWVKQN 472
Cdd:TIGR03970 352 ---PHSRGRIRLASADPADPPRIEHRYDSSAADRAALRAGAALAHELLGSP--------ELGPLLEPAVREGEASWVLAR 420

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 873903935  473 VESAYHPSCGCKMGADDDPMAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERASDLIL 539
Cdd:TIGR03970 421 LATSQHLCGSCRMGGRDDPGAVVDARCRVRGVEGLWVVDGSILPVIPSRGPHATAVMVAERAAEFLG 487
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 73-306 1.99e-55

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 186.33  E-value: 1.99e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   73 DGRELHCPRGKVLGGSSSINGMVYVRGHACDFDQWEEE-GAAGWNYQACLPYFRRAEswnkggdeyrgdnGPVGTCNGND 151
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWASEfGLEGWGYDDYLPYMDKVE-------------GPLGVTTKGI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  152 mELNPLYQAFIDAGKDAGYPETN---DYNGYQQEGFGtmHMTVDKGVRASTSNAYLRRALKRsNLTLKKGIVARRFLLEa 228
Cdd:pfam00732  82 -EESPLNQALLKAAEELGYPVEAvprNSNGCHYCGFC--GLGCPTGAKQSTARTWLRPALER-NLRILTGAKAEKIIIL- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  229 qdsngQSGLKAVGVEFE--KSGNTQVAVANKEVISSAGSIGSVQLLQLSGIGPKavlekagvevKHelsGVGENLQDHLE 306
Cdd:pfam00732 157 -----GRGGRAVGVEARdgGGGIKRLITAAKEVVVAAGALNTPPLLLRSGLGKN----------PH---PVGKNLQLHPV 218
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 396-534 2.94e-48

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 164.49  E-value: 2.94e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  396 PESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRG-----EEIQPGLSVTSDEAIDEWVK 470
Cdd:pfam05199   1 PRSRGRVTLSSSDPTGLPVIDPNYLSDPADLAALRAALRLARRILAAAGLVLGVEltpgpVPEVSDAAVTSDDELLAYIR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 873903935  471 QNVESAYHPSCGCKMGADDDPmAVLDEECRVRGIDNLRVVDSSVFPVIPNGNLNAPTIMVAERA 534
Cdd:pfam05199  81 AAASTSYHPMGTCRMGADPDD-AVVDPDLRVHGVDNLRVVDASVFPSSPSGNPTLTIYALAERA 143
PLN02785 PLN02785
Protein HOTHEAD
 5-533 8.21e-27

Protein HOTHEAD


Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 114.90  E-value: 8.21e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935   5 YDYIIVGAGSAGCVLADRLteSGEHSVLLLEAGGT-----DKSIFIQMPTALSYPMNTEKYAWQFETeqepglDGreLHC 79
Cdd:PLN02785  56 YDYIVVGGGTAGCPLAATL--SQNFSVLLLERGGVpfgnaNVSFLENFHIGLADTSPTSASQAFIST------DG--VIN 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935  80 PRGKVLGGSSSINGMVYVRGHAcDFDQweeegAAGWNYQ---ACLPYF-RRAESWNKggdeyrgdngpvgtcngndmeLN 155
Cdd:PLN02785 126 ARARVLGGGTCINAGFYSRAST-RFIQ-----KAGWDAKlvnESYPWVeRQIVHWPK---------------------VA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 156 PLYQAFIDAGKDAGypeTNDYNGYQQEG-FGT-MHMTV-DKGVRASTSnAYLRRALKRSNLTLKKGIVARRFLLEAqdsn 232
Cdd:PLN02785 179 PWQAALRDSLLEVG---VSPFNGFTYDHvYGTkVGGTIfDEFGRRHTA-AELLAAGNPNKLRVLLHATVQKIVFDT---- 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 233 GQSGLKAVGVEF--EKSGNTQVAVANK---EVISSAGSIGSVQLLQLSGIGPKAVLEKAGVEVKHELSGVGENLQDHLEV 307
Cdd:PLN02785 251 SGKRPRATGVIFkdENGNQHQAFLSNNkgsEIILSAGAIGSPQMLLLSGIGPKKELKKHKIPVVLHNEHVGKGMADNPMN 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 308 YFQYHCNEPI--TLNSKLGLVSKGMigaeWILTRKGLGatnhfESCAFIRSRKGLKWPNI-QYHFLPAAMR--------- 375
Cdd:PLN02785 331 SIFVPSKAPVeqSLIQTVGITKMGV----YIEASSGFG-----QSPDSIHCHHGIMSAEIgQLSTIPPKQRtpeaiqayi 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 376 ----YDGQAAFDGhGFQVHVGPNkPESRGTVAITSADPHAKPEIIFNYISTEQDRQDWRDCIRLTREILSQPAMDAYRGE 451
Cdd:PLN02785 402 hrkkNLPHEAFNG-GFILEKIAG-PISTGHLSLINTNVDDNPSVTFNYFKHPQDLQRCVYGIRTIEKIVKTNHFTNFTQC 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 873903935 452 EIQP-----GLSVTSD-----------EAIDEWVKQNVESAYHPSCGCKMGadddpmAVLDEECRVRGIDNLRVVDSSVF 515
Cdd:PLN02785 480 DKQTmekvlNMSVKANinlipkhtndtKSLEQFCKDTVITIWHYHGGCHVG------KVVDQNYKVLGVSRLRVIDGSTF 553

                        570
                 ....*....|....*...
gi 873903935 516 PVIPNGNLNApTIMVAER 533
Cdd:PLN02785 554 DESPGTNPQA-TVMMMGR 570
Glf COG0562
UDP-galactopyranose mutase [Cell wall/membrane/envelope biogenesis];
5-35 7.57e-06

UDP-galactopyranose mutase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440328 [Multi-domain]  Cd Length: 365  Bit Score: 48.17  E-value: 7.57e-06
                         10        20        30
                 ....*....|....*....|....*....|.
gi 873903935   5 YDYIIVGAGSAGCVLADRLTESGEHSVLLLE 35
Cdd:COG0562    3 YDYLIVGAGFFGAVFAERLAEELGKKVLVID 33
PRK06370 PRK06370
FAD-containing oxidoreductase;
1-39 8.79e-05

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 45.19  E-value: 8.79e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 873903935   1 MEQRYDYIIVGAGSAGCVLADRLTESGeHSVLLLEA---GGT 39
Cdd:PRK06370   2 PAQRYDAIVIGAGQAGPPLAARAAGLG-MKVALIERgllGGT 42
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
3-38 9.91e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 44.90  E-value: 9.91e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 873903935   3 QRYDYIIVGAGSAGCVLADRLTESGeHSVLLLEAGG 38
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRG-LDVTVLERGR 35
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 5-35 1.31e-03

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 41.15  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 873903935    5 YDYIIVGAGSAGCVLADRLTESGeHSVLLLE 35
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKG-LRVLLLE 30
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
1-36 2.42e-03

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 40.51  E-value: 2.42e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 873903935   1 MEQRYDYIIVGAGSAGCVLADRLTESGEHSVLLLEA 36
Cdd:COG0579    1 MMEMYDVVIIGAGIVGLALARELSRYEDLKVLVLEK 36
Lycopene_cycl pfam05834
Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. ...
 6-73 2.96e-03

Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclization of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare.


Pssm-ID: 310433 [Multi-domain]  Cd Length: 380  Bit Score: 40.09  E-value: 2.96e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 873903935    6 DYIIVGAGSAGCVLADRLTESGEH-SVLLLEAGGTdksifiqmptalsyPMNTEKYAWQFETEQEPGLD 73
Cdd:pfam05834   1 DVVIIGAGPAGLSLAARLAAAKPGlSVVLIEPGPS--------------LLRPNNYVWSDEFEDLGALE 55
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 2-39 4.48e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 39.68  E-value: 4.48e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 873903935   2 EQRYDYIIVGAGSAGCVLADRLTESGEhSVLLLEA---GGT 39
Cdd:COG1249    1 MKDYDLVVIGAGPGGYVAAIRAAQLGL-KVALVEKgrlGGT 40
PTZ00367 PTZ00367
squalene epoxidase; Provisional
 5-35 5.33e-03

squalene epoxidase; Provisional


Pssm-ID: 240384 [Multi-domain]  Cd Length: 567  Bit Score: 39.45  E-value: 5.33e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 873903935   5 YDYIIVGAGSAGCVLADRLTESGEhSVLLLE 35
Cdd:PTZ00367  34 YDVIIVGGSIAGPVLAKALSKQGR-KVLMLE 63
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
4-38 6.36e-03

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 39.13  E-value: 6.36e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 873903935   4 RYDYIIVGAGSAGCVLADRLTESGeHSVLLLEA----GG 38
Cdd:COG1231    7 GKDVVIVGAGLAGLAAARELRKAG-LDVTVLEArdrvGG 44
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 1-39 6.60e-03

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 39.08  E-value: 6.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 873903935   1 MEQRYDYIIVGAGSAGCVLADRLTESGeHSVLLLEA----GGT 39
Cdd:COG2072    3 ATEHVDVVVIGAGQAGLAAAYHLRRAG-IDFVVLEKaddvGGT 44
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
9-37 7.09e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 35.20  E-value: 7.09e-03
                          10        20
                  ....*....|....*....|....*....
gi 873903935    9 IVGAGSAGCVLADRLTESGeHSVLLLEAG 37
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRG-FRVLVLEKR 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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