NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|880806243|ref|WP_048658421|]
View 

aminodeoxychorismate synthase component I [Vibrio crassostreae]

Protein Classification

anthranilate synthase component I family protein( domain architecture ID 11414943)

anthranilate synthase component I family protein similar to the component I of anthranilate synthase and aminodeoxychorismate synthase, which are part of complexes that catalyze the two-step biosynthesis of anthranilate and 4-amino-4-deoxychorismate (ADC), respectively

CATH:  3.60.120.10
Gene Ontology:  GO:0046872|GO:0009058
PubMed:  16042594|11450855

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 23-457 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


:

Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 568.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  23 QLFSHVENLPWAMLLRSASESHVDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSDPFELLDQYQQQLLPVTKDHaE 102
Cdd:COG0147   17 SLFLKLADGPYAFLLESAEGGEKWGRYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARFRLPPLPG-L 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 103 LPFVGGALGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTacivgnnieqhhdwlmqqlvqskpthaa 182
Cdd:COG0147   96 PPFTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFDHLKGT---------------------------- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 183 fglttpwQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSP 262
Cdd:COG0147  148 -------RSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPYMFYLRFGDFAIVGSSP 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 263 ERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAV 342
Cdd:COG0147  221 ERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPELMVVERYSHV 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 343 HHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAENN 422
Cdd:COG0147  301 MHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIAIRTAVVKDG 380

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 880806243 423 TLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLE 457
Cdd:COG0147  381 RAYVQAGAGIVADSDPEAEYQETLNKARALLRALE 415
 
Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 23-457 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 568.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  23 QLFSHVENLPWAMLLRSASESHVDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSDPFELLDQYQQQLLPVTKDHaE 102
Cdd:COG0147   17 SLFLKLADGPYAFLLESAEGGEKWGRYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARFRLPPLPG-L 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 103 LPFVGGALGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTacivgnnieqhhdwlmqqlvqskpthaa 182
Cdd:COG0147   96 PPFTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFDHLKGT---------------------------- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 183 fglttpwQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSP 262
Cdd:COG0147  148 -------RSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPYMFYLRFGDFAIVGSSP 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 263 ERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAV 342
Cdd:COG0147  221 ERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPELMVVERYSHV 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 343 HHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAENN 422
Cdd:COG0147  301 MHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIAIRTAVVKDG 380

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 880806243 423 TLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLE 457
Cdd:COG0147  381 RAYVQAGAGIVADSDPEAEYQETLNKARALLRALE 415
pabB PRK15465
aminodeoxychorismate synthase component 1;
14-458 0e+00

aminodeoxychorismate synthase component 1;


Pssm-ID: 185362 [Multi-domain]  Cd Length: 453  Bit Score: 566.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  14 LEYQSTLAKQLFSHVENLPWAMLLRSASESHVDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSDPFELLDQYQQQL 93
Cdd:PRK15465  11 LPWRQDAAEFYFSRLSHLPWAMLLHSGYADHPYSRFDIVVADPICTLTTFGKETVVSESEKRTTTTDDPLQVLQQVLDRA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  94 LPVTKDHAELPFVGGALGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTACIVG-NNIEQHHDWLMQQ 172
Cdd:PRK15465  91 DIRPTHNEDLPFQGGALGLFGYDLGRRFESLPEIAEQDIVLPDMAVGIYDWALIVDHQRQTVSLLShNDVNARRAWLESQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 173 lvqSKPTHAAFGLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRL 252
Cdd:PRK15465 171 ---QFSPQEDFTLTSDWQSNMTREQYGEKFRQVQEYLHSGDCYQVNLAQRFHATYSGDEWQAFLQLNQANRAPFSAFLRL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 253 ANCAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPK 332
Cdd:PRK15465 248 EQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 333 LFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSI 412
Cdd:PRK15465 328 LFVVEPFPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTSI 407

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 880806243 413 TIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLED 458
Cdd:PRK15465 408 TIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDKVNRILRQLEK 453
pabB TIGR00553
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ...
 109-452 1.77e-129

aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 273133  Cd Length: 328  Bit Score: 377.49  E-value: 1.77e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  109 ALGYFSYDLGrrvetlpsrakrdieaPDMAVGLYEWAVVVDHQlktacivgnniEQHHDWLMQQ-----------LVQSK 177
Cdd:TIGR00553   1 LVGYLSYEAG----------------PDAAFEPYDAALLADHR-----------RTPLLRFLVFerveaqpraavEAEDD 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  178 PTHAAFGLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCAI 257
Cdd:TIGR00553  54 APADRQAPTSDIQSEMTRAEYGEAIDQLQDYIRAGDCYQANLTQQFHATWDGDPLAAFRKLRRRQPAPFSAFLDLGDGAI 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  258 ISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIE 337
Cdd:TIGR00553 134 LSLSPELFFSIDGSEIETRPIKGTLPRGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVVE 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  338 SFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTL 417
Cdd:TIGR00553 214 TYPTVHQLVSTITARLREDLTLSDLFRALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRTL 293

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 880806243  418 VAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRI 452
Cdd:TIGR00553 294 TLDGGRAVYGVGGGIVADSDPEAEYRECLLKAAPL 328
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 196-448 4.41e-123

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 358.40  E-value: 4.41e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  196 ESYATKFDSVQEYLLSGDCYQINLAQRFNAQ--YQGSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSPERFLELKDNVI 273
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPlaGDIDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  274 ETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADL 353
Cdd:pfam00425  81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  354 DDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAENNTLYAWAGGGVV 433
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240

                         250
                  ....*....|....*
gi 880806243  434 FDSDCASEYQETLDK 448
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
 
Name Accession Description Interval E-value
TrpE COG0147
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ...
 23-457 0e+00

Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439917 [Multi-domain]  Cd Length: 416  Bit Score: 568.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  23 QLFSHVENLPWAMLLRSASESHVDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSDPFELLDQYQQQLLPVTKDHaE 102
Cdd:COG0147   17 SLFLKLADGPYAFLLESAEGGEKWGRYSFIGADPLATLTVRGGRVTIEGGGEVEPSEGDPLDALRALLARFRLPPLPG-L 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 103 LPFVGGALGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTacivgnnieqhhdwlmqqlvqskpthaa 182
Cdd:COG0147   96 PPFTGGLVGYFGYDLVRYFERLPDLAPDDLGLPDAALGLYDRLLVFDHLKGT---------------------------- 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 183 fglttpwQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSP 262
Cdd:COG0147  148 -------RSNFTREEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPYMFYLRFGDFAIVGSSP 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 263 ERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAV 342
Cdd:COG0147  221 ERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPELMVVERYSHV 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 343 HHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAENN 422
Cdd:COG0147  301 MHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIAIRTAVVKDG 380

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 880806243 423 TLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLE 457
Cdd:COG0147  381 RAYVQAGAGIVADSDPEAEYQETLNKARALLRALE 415
pabB PRK15465
aminodeoxychorismate synthase component 1;
14-458 0e+00

aminodeoxychorismate synthase component 1;


Pssm-ID: 185362 [Multi-domain]  Cd Length: 453  Bit Score: 566.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  14 LEYQSTLAKQLFSHVENLPWAMLLRSASESHVDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSDPFELLDQYQQQL 93
Cdd:PRK15465  11 LPWRQDAAEFYFSRLSHLPWAMLLHSGYADHPYSRFDIVVADPICTLTTFGKETVVSESEKRTTTTDDPLQVLQQVLDRA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  94 LPVTKDHAELPFVGGALGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTACIVG-NNIEQHHDWLMQQ 172
Cdd:PRK15465  91 DIRPTHNEDLPFQGGALGLFGYDLGRRFESLPEIAEQDIVLPDMAVGIYDWALIVDHQRQTVSLLShNDVNARRAWLESQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 173 lvqSKPTHAAFGLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRL 252
Cdd:PRK15465 171 ---QFSPQEDFTLTSDWQSNMTREQYGEKFRQVQEYLHSGDCYQVNLAQRFHATYSGDEWQAFLQLNQANRAPFSAFLRL 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 253 ANCAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPK 332
Cdd:PRK15465 248 EQGAILSLSPERFILCDNSEIQTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 333 LFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSI 412
Cdd:PRK15465 328 LFVVEPFPAVHHLVSTITARLPEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTSI 407

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 880806243 413 TIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLED 458
Cdd:PRK15465 408 TIRTLTAINGQIYCSAGGGIVADSQEEAEYQETFDKVNRILRQLEK 453
pabB TIGR00553
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ...
 109-452 1.77e-129

aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 273133  Cd Length: 328  Bit Score: 377.49  E-value: 1.77e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  109 ALGYFSYDLGrrvetlpsrakrdieaPDMAVGLYEWAVVVDHQlktacivgnniEQHHDWLMQQ-----------LVQSK 177
Cdd:TIGR00553   1 LVGYLSYEAG----------------PDAAFEPYDAALLADHR-----------RTPLLRFLVFerveaqpraavEAEDD 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  178 PTHAAFGLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCAI 257
Cdd:TIGR00553  54 APADRQAPTSDIQSEMTRAEYGEAIDQLQDYIRAGDCYQANLTQQFHATWDGDPLAAFRKLRRRQPAPFSAFLDLGDGAI 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  258 ISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIE 337
Cdd:TIGR00553 134 LSLSPELFFSIDGSEIETRPIKGTLPRGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVVE 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  338 SFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTL 417
Cdd:TIGR00553 214 TYPTVHQLVSTITARLREDLTLSDLFRALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRTL 293

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 880806243  418 VAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRI 452
Cdd:TIGR00553 294 TLDGGRAVYGVGGGIVADSDPEAEYRECLLKAAPL 328
trpE_most TIGR00564
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ...
 36-457 4.73e-125

anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]


Pssm-ID: 273142 [Multi-domain]  Cd Length: 454  Bit Score: 370.90  E-value: 4.73e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243   36 LLRSASESHVDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSDPFELLDQYQQQLLPVTKDHAELPFVGGALGYFSY 115
Cdd:TIGR00564  20 LLESAEPGSERGRYSFIGLNPVLTIKTEGGTEYLGADDRRSGIVGNPLDEIRDVMETFAQHSDPELPIPFTGGAVGYLGY 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  116 DLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTACIVGNNI-------EQHHDWLMQQLVQ--SKPTHAAFGLT 186
Cdd:TIGR00564 100 DTVRLFEKITLPPPDPLNLPDAYLMLCDDFIIFDHVTDKLYLIHNNRttasrsaKAAADARLEALVAdlQDPLLPEVPVP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  187 TPWQ----SNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSP 262
Cdd:TIGR00564 180 YPAAlsftSNYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYRVLRIVNPSPYMYYLDFGDFQIVGSSP 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  263 ERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAV 342
Cdd:TIGR00564 260 ELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVCEPGSVEVPEFMKIERYSHV 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  343 HHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAENN 422
Cdd:TIGR00564 340 MHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYGGAVGYLSFDGDMDTAIAIRTMVVKDG 419

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 880806243  423 TLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLE 457
Cdd:TIGR00564 420 KAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
Chorismate_bind pfam00425
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ...
 196-448 4.41e-123

chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.


Pssm-ID: 425674 [Multi-domain]  Cd Length: 255  Bit Score: 358.40  E-value: 4.41e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  196 ESYATKFDSVQEYLLSGDCYQINLAQRFNAQ--YQGSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSPERFLELKDNVI 273
Cdd:pfam00425   1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPlaGDIDPLALYRRLRARNPAPYSFYFRTGDFTFLGASPERLLSVDGGRI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  274 ETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADL 353
Cdd:pfam00425  81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  354 DDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAENNTLYAWAGGGVV 433
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240

                         250
                  ....*....|....*
gi 880806243  434 FDSDCASEYQETLDK 448
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
PabB-clade2 TIGR01824
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ...
 107-452 4.50e-115

aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.


Pssm-ID: 130883  Cd Length: 355  Bit Score: 342.14  E-value: 4.50e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  107 GGALGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQ-----LKTACIVGNNIEQHHDWLMQQL--VQSKPT 179
Cdd:TIGR01824   1 GGRLGWLAYDVARRLEGIPDLGTSDGGWPVAADFRYEAAVARDHQrqivaLATVPAETEGEFATSSDQLPAVaaATSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  180 HAAFGLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQ--GSEWLAYDKLEQYNSAPFSGFIRLANCAI 257
Cdd:TIGR01824  81 PDVGPLPVDLEASIDRAAYETGVRRIKDYIRAGDVFQANLSRRLTAPIAadVDPLQLFLALRAPNPAPYAIYLEEPGVDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  258 ISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIE 337
Cdd:TIGR01824 161 ASASPELFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVCATGTVRVPELCAVE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  338 SFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTL 417
Cdd:TIGR01824 241 SYSHVHHLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWIDADGNADLNILIRTL 320

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 880806243  418 VAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRI 452
Cdd:TIGR01824 321 EGGGAQLHFRTGAGIVADSDPAGEWDETEAKARAL 355
PRK07508 PRK07508
aminodeoxychorismate synthase component I;
111-453 8.55e-102

aminodeoxychorismate synthase component I;


Pssm-ID: 236035 [Multi-domain]  Cd Length: 378  Bit Score: 308.86  E-value: 8.55e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 111 GYFSYDLGRRVET-LPSRAKRDIEAPDMAVGLYEWAVVVDHqlktacivgnnieqhhdwlmqqLVQSKPTHAAFglTTPW 189
Cdd:PRK07508  50 GYLSYEAGYLLEPkLAPLMPEGRETPLLCFGVFDAPSPEAP----------------------APARPSENAAR--LRDP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 190 QSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSPERFLELK 269
Cdd:PRK07508 106 VARWDFADYAQRFERLHRHIRAGDCYQANLTFPLDARWGGDPLALFWALAARQPVGYGALVDLGGPVILSRSPELFFRVD 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 270 -DNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAVHHLVST 348
Cdd:PRK07508 186 gEGWIETHPMKGTAPRGATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFDIETYPTVHQMVSR 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 349 IRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLV-AENNTLYAW 427
Cdd:PRK07508 266 VRARLLPGLGLADIFAALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNVAIRTLSlFPGGRAVFN 345

                        330       340
                 ....*....|....*....|....*.
gi 880806243 428 AGGGVVFDSDCASEYQETLDKlSRIL 453
Cdd:PRK07508 346 VGGGIVFDSTAEAEYEECLLK-ARFA 370
PRK09070 PRK09070
aminodeoxychorismate synthase component I;
36-457 1.22e-99

aminodeoxychorismate synthase component I;


Pssm-ID: 236371 [Multi-domain]  Cd Length: 447  Bit Score: 305.47  E-value: 1.22e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  36 LLRSASESHVDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSDPFELLDQYQQQllpvtkDHAELPFVGGALGYFSY 115
Cdd:PRK09070  27 LLESSASGTAQGRWDVLLLAQGKCLRLDPDGVTRQLLEGDFLDALDAAWQAERVPHD------GESSLPFRGGWAVLLDY 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 116 DLGRRVE-TLPSRAKRDIEAPDMAVGLyEWAVVVDHQLKTACIVGnniEQHHDWLMQQLVQSKPTHAAFGLTTPWQSNMS 194
Cdd:PRK09070 101 ELAGQVEpILKLPMRTDGLPLALALRA-PAAVLRDRHSGRCVLVA---EPGREHLLDQIEADLAACAALPPLPVWLAPQA 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 195 -EESYATKFDS----VQEYLLSGDCYQINLAQRFNAQYQGSEWLA--YDKLEQYNSAPFSGFIRLANCAIISVSPERFLE 267
Cdd:PRK09070 177 vEEDPPERFTDgverVLDYIRAGDVFQVNLSRAWQAQFANAVDPAalYARLRAANPAPFSGLFVAAGRAIVSSSPERLVS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 268 LKDNVIETKPIKGTRPRSDDhVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAVHHLVS 347
Cdd:PRK09070 257 VQGGVVQTRPIAGTRPRFAG-DDDAALIRELVGHPKERAEHVMLIDLERNDLGRICAPGSVEVDELMTVESYAHVHHIVS 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 348 TIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAENNTLYAW 427
Cdd:PRK09070 336 NVRGRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRGAYTGSFGYLNRDGDMDLNILIRTAEVQGNQVRFR 415

                        410       420       430
                 ....*....|....*....|....*....|
gi 880806243 428 AGGGVVFDSDCASEYQETLDKLSRILPVLE 457
Cdd:PRK09070 416 TGAGIVVDSDPERELDETRAKARGLLRALE 445
PRK05940 PRK05940
anthranilate synthase component I;
13-458 5.20e-93

anthranilate synthase component I;


Pssm-ID: 235651 [Multi-domain]  Cd Length: 463  Bit Score: 288.94  E-value: 5.20e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  13 PLEYQ--STLAKQLFSHVenlPWAMLLRSASESHVD----SRYDILVAQPiatfetigAKTTVnvnETCEVSDSDPFELL 86
Cdd:PRK05940  14 PLNGRtgSEIFERLFGQQ---GIATLLESPYPTPADypplSRYSICAGSP--------RKPRL---WTPKLGEILPFLRQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  87 DQYQQQLLPVTKDHaeLPFVGGALGYFSYDLGRRVETLPSRaKRDIeAPDMAVGLYEWAV--VVDHQLKTACIVGNNIEQ 164
Cdd:PRK05940  80 LLARSLDPSALPEH--LPFTGGWLGWLGYDLAWEIERLPHL-NPDP-LPFPVAYWYEPESfaILDHQEQILWLAASDPSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 165 HhDWLMQQLVQSKPTHaafGLTTPWQSN-------MSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDK 237
Cdd:PRK05940 156 L-DRLEQQLEQPTPEP---DLPLDLRTPpsslifyTTQQEYEAAVRQAKKYIQAGDIFQANLSLRFQTTTSADSWQIYRR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 238 LEQYNSAPFSGFIRLANCAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRN 317
Cdd:PRK05940 232 LQQINPSPFASYWRTPWGDVVSCSPERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERN 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 318 DIGRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCG 397
Cdd:PRK05940 312 DLGRVCQWGSVEVDELLTIERYSHVIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYG 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 880806243 398 SIGYISRNGRMDTSITIRTLVAENN-----TLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLED 458
Cdd:PRK05940 392 SCGYLDQRGNLDLNILIRTLLYTPLsrglsTIWGQVGAGIVADSDPEKEWLESLQKAKAQLAALNL 457
PRK13571 PRK13571
anthranilate synthase component I; Provisional
 104-453 1.99e-90

anthranilate synthase component I; Provisional


Pssm-ID: 184152 [Multi-domain]  Cd Length: 506  Bit Score: 283.84  E-value: 1.99e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 104 PFVGGALGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTACIVGNNI-----EQHHDWL--------- 169
Cdd:PRK13571 120 PLTGGMVGFLGYDAVRRLERLPELAVDDLGLPEMLLLLATDLAAVDHHEGTITLIANAVnwngtDERVDAAyddavarld 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 170 -MQQ-LVQ-SKPTHAAFGLTTP-WQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAP 245
Cdd:PRK13571 200 vMTAaLAQpLPSTVATFSRPVPeFRAQRTVEEFGAAVEKLVEEIRAGEAFQVVPSQRFEMDTTADPLDVYRVLRVTNPSP 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 246 FSGFIRLANCA------IISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDI 319
Cdd:PRK13571 280 YMYLLRVPNSDggtdfsIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKERAEHLMLVDLGRNDL 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 320 GRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSI 399
Cdd:PRK13571 360 GRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELIEELEPTRRGLYGGVV 439

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 880806243 400 GYISRNGRMDTSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRIL 453
Cdd:PRK13571 440 GYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVL 493
PLN02445 PLN02445
anthranilate synthase component I
 24-448 3.64e-83

anthranilate synthase component I


Pssm-ID: 215244 [Multi-domain]  Cd Length: 523  Bit Score: 265.39  E-value: 3.64e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  24 LFSHVENlpwamllrsASESHVDSRYDILVAQPiaTFETIGAKTTVNV------NETCEVSDsDPFELLDQYQQQLLPVT 97
Cdd:PLN02445  43 LFESVEP---------GSQSSNVGRYSVVGAQP--AMEIVAKENKVTImdhekgTRTEEIVE-DPMEIPRRISEKWNPQL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  98 KDhaELP--FVGGALGYFSYDLGRRVET--LP-SRAKRDIEA-PDMAVGLYEWAVVVDHQLKTACIVG------------ 159
Cdd:PLN02445 111 ID--GLPdvFCGGWVGYFSYDTVRYVEKkkLPfSGAPEDDRNlPDIHLGLYDDVIVFDHVEKKAYVIHwvrldryssvee 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 160 --NNIEQHHDWLMQQLVQSKPTHAAFGL---------TTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQ 228
Cdd:PLN02445 189 ayEDGMKRLEALVSRLQDINPPKLSPGSvklstnqfgPSLEKSNMTSEEYKNAVLQAKEHILAGDIFQIVLSQRFERRTF 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 229 GSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAEN 308
Cdd:PLN02445 269 ADPFEVYRALRIVNPSPYMIYLQARGCILVASSPEILTRVKKNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEH 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 309 LMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELE 388
Cdd:PLN02445 349 IMLVDLGRNDVGKVSKAGSVKVEKLMNIERYSHVMHISSTVTGELLDHLTSWDALRAALPVGTVSGAPKVRAMELIDELE 428

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 880806243 389 PHRRSAYCGSIGYISRNGRMDTSITIRTLV----AENNTLYA---------W-----AGGGVVFDSDCASEYQETLDK 448
Cdd:PLN02445 429 VTRRGPYSGGFGGVSFTGDMDIALALRTMVfptaARYDTMYSykdtnsrreWvahlqAGAGIVADSDPEDEYRECVNK 506
PRK13574 PRK13574
anthranilate synthase component I; Provisional
 34-455 1.83e-75

anthranilate synthase component I; Provisional


Pssm-ID: 184155 [Multi-domain]  Cd Length: 420  Bit Score: 242.41  E-value: 1.83e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  34 AMLLRSASESHVDSRYDILVAqpiatfetiGAKTTVNVNEtcevsdsDPFELLDQYQQQLlpvtkDHAELP--FVGGALG 111
Cdd:PRK13574  26 AGLLESIGGPQYKARYSVIAW---------GTNGYLKIHD-------DPVNILNSYLKDL-----KLVDIPglFKGGMIG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 112 YFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTACIVGNNIEqhhdwlmqqlVQSKPTHAAFGLTtPWQS 191
Cdd:PRK13574  85 YISYDAVRFWEKIRDLKPAAEDWPYAEFFIPDNIIIYDHNEGKVYVNGDLSS----------VGGCGDMGEFKIS-FYDE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 192 NMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCAIISVSPERFLELKDN 271
Cdd:PRK13574 154 SLNKNNYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFYLKFDERYLIGSSPELLFRVQDN 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 272 VIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAVHHLVSTIRA 351
Cdd:PRK13574 234 IVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVPELMYVEKYSHVQHIVSKVIG 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 352 DLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAENNTLYAWAGGG 431
Cdd:PRK13574 314 TLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKDLLRIQAGAG 393

                        410       420
                 ....*....|....*....|....
gi 880806243 432 VVFDSDCASEYQETLDKLsRILPV 455
Cdd:PRK13574 394 IVYDSNPESEYFETEHKL-RALKT 416
PLN02889 PLN02889
oxo-acid-lyase/anthranilate synthase
 98-448 1.51e-74

oxo-acid-lyase/anthranilate synthase


Pssm-ID: 215481 [Multi-domain]  Cd Length: 918  Bit Score: 251.31  E-value: 1.51e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  98 KDHAELPF--VGGALGYFSYDLGRRVETLPSRAKRDieAPDMAVGLYEWAVVVDHQLKTACIVG------------NNIE 163
Cdd:PLN02889 529 KDFEGLPFdfHGGYVGYIGYDLKVECGMASNRHKST--TPDACFFFADNVVVIDHHYDDVYILSlhegstattqwlDDTE 606

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 164 QHHDWLMQQL-----VQSKPTHAAFGLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLA-YDK 237
Cdd:PLN02889 607 QKLLGLKASAtrkleVQTSPTATFSPSKAGFLADKSREQYIKDVQKCLKYIKDGESYELCLTTQMRKRIGEIDSLGlYLH 686

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 238 LEQYNSAPFSGFIRL--ANCAIISVSPERFLELKDN-VIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDL 314
Cdd:PLN02889 687 LREKNPAPYAAWLNFsnENLCICSSSPERFLKLDRNgMLEAKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDL 766

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 315 LRNDIGRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSA 394
Cdd:PLN02889 767 LRNDLGRVCEPGSVHVPNLMDVESYTTVHTMVSTIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSMELLDSLESSSRGI 846

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 880806243 395 YCGSIGYISRNGRMDTSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDK 448
Cdd:PLN02889 847 YSGSIGFFSYNQTFDLNIVIRTVVIHEGEASIGAGGAIVALSNPEDEYEEMILK 900
PRK13572 PRK13572
anthranilate synthase component I; Provisional
 9-457 5.62e-70

anthranilate synthase component I; Provisional


Pssm-ID: 237432 [Multi-domain]  Cd Length: 435  Bit Score: 228.47  E-value: 5.62e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243   9 IQIKPLEYQSTLakQLFSHVENLPWAMLLRSASESHVDSRYDILVAQPIATFEtIGAKTTVNvNETceVSD-SDPFELLD 87
Cdd:PRK13572   1 MLMKKLDYVNPL--KLYSVLRDEGYPFILESAEKGQRKARYTYISANPEFMVR-IGNKTKVD-GET--ISKeSNPFKALK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  88 QYQQQLlpVTKDHaelpFVGGALGYFSYD-----LGRRVETlPSRakrdieapdmaVGLYEWAVVVDHQLKTACIVGNNI 162
Cdd:PRK13572  75 ENFKIT--QSGDR----FTGGFVGYIAYDavhnyIGGKIEE-PSV-----------FGYYDHVFVYDHVTRKFYFHSLNN 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 163 EQHHDWLMQQLVQ-SKPTHAAF--GLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLE 239
Cdd:PRK13572 137 NPEELFNAEKIVEkAKRFEIEEedGGSEVLGCDADREEFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDLSPFQLYRNLR 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 240 QYNSAPFSgFIRLANCAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDI 319
Cdd:PRK13572 217 EINPSPYM-FLLEFDKDVVGASPETMASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDV 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 320 GRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSI 399
Cdd:PRK13572 296 RKVSKSGSVRLERFFDVVKYSHVQHIESEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAV 375

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 880806243 400 GYISRNGRMDTSITIRTlvAE-NNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLE 457
Cdd:PRK13572 376 GYFSNSGNADLAIAIRM--AEiDKVCRVRAGAGIVADSVPEKEFYETERKMAAVLKALG 432
PRK13564 PRK13564
anthranilate synthase component 1;
97-448 7.37e-70

anthranilate synthase component 1;


Pssm-ID: 237428 [Multi-domain]  Cd Length: 520  Bit Score: 230.49  E-value: 7.37e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  97 TKDHAELPFVGGAlgyFSYDLGRRVETLPSrAKRDIEAPDMAVGLYEWAVVVDHQLKTACIVG----------NNIEQHH 166
Cdd:PRK13564 137 PKEEREALFLGGL---FAYDLVAGFEPLPQ-LPAGNNCPDYCFYLAETLLVIDHQKKSARLQAslftpdeeekQRLAARL 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 167 DWLMQQLVQSKPT-HAAFGLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQgSEWLAYDKLEQYNSAP 245
Cdd:PRK13564 213 AQLKQQLTQPAPPlPVTSVPDMEVSVNISDEEFCAVVRKLKEHIRAGDIFQVVPSRRFSLPCP-SPLAAYRVLKKSNPSP 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 246 FSGFIRLANCAIISVSPERFL--ELKDNVIETKPIKGTRPR------SDDHVIDDANAQDLASADKDQAENLMIVDLLRN 317
Cdd:PRK13564 292 YMFYMQDEDFTLFGASPESALkyDASSRQVEIYPIAGTRPRgrradgSIDRDLDSRIELELRTDHKELAEHLMLVDLARN 371

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 318 DIGRVAKPGTVHVPKLFDIESFPAVHHLVS----TIRADLDdqysATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRS 393
Cdd:PRK13564 372 DLARICQPGSRYVADLLKVDRYSHVMHLVSrvvgELRHDLD----ALHAYRACMNMGTLTGAPKVRAMQLIREVEGQRRG 447

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 880806243 394 AYCGSIGYISRNGRMDTSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDK 448
Cdd:PRK13564 448 SYGGAVGYLTGHGDLDTCIVIRSAFVENGIATVQAGAGVVLDSDPQSEADETRNK 502
PRK05877 PRK05877
aminodeoxychorismate synthase component I; Provisional
 107-453 5.16e-68

aminodeoxychorismate synthase component I; Provisional


Pssm-ID: 235634 [Multi-domain]  Cd Length: 405  Bit Score: 222.66  E-value: 5.16e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 107 GGALGYFSY-DLGRRvetlpSRAKRdieAPDMAVGlyeWAvvvDHQLK--------TACIVGNNIEqhhDWLMQQLvqsk 177
Cdd:PRK05877  63 GGWFGYLSYpDAGAD-----GRPPR---IPEAAGG---WT---DHVLRrdrdgqwwYESLSGAPDP---DWLASAL---- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 178 pTHAAFGLTTPWQSNMSEESYATKFDSV---QEYLLSGDCYQINLAQRFNAQYQGS--EWLAyDKLEQynSAP-FSGFIR 251
Cdd:PRK05877 122 -ATTRARPAPPCRIDWTPPDRAAHRDGVlacLEAIAAGEVYQACVCTQFTGTVTGSplDFFA-DGVAR--TAPaRAAYLA 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 252 LANCAIISVSPERFLELKDNVIETKPIKGTRPRsddhvidDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVP 331
Cdd:PRK05877 198 GDWGAVASLSPELFLRRRGSVVTSSPIKGTLPL-------DADPSALRASAKDVAENIMIVDLVRNDLGRVARTGTVTVP 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 332 KLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTS 411
Cdd:PRK05877 271 ELLVVRPAPGVWHLVSTVSAQVPDELPMSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELN 350

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 880806243 412 ITIRTL-VAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRIL 453
Cdd:PRK05877 351 VAIRTVeFDADGNAVLGVGGGITADSDPDAEWQECLHKAAPIV 393
PRK13567 PRK13567
anthranilate synthase component I; Provisional
 35-455 7.58e-61

anthranilate synthase component I; Provisional


Pssm-ID: 184148 [Multi-domain]  Cd Length: 468  Bit Score: 205.38  E-value: 7.58e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243  35 MLLRSASESHVDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSDPFELLDQYQQQLLPVTKDH--AELPFVGGALGY 112
Cdd:PRK13567  25 IILESTNQQQTKGRYSVVIFDIYGTLTLDNDVLSVSTLKESYQITERPYHYLTTKINEDYHNIQDEqlKSLPFISGYVGT 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 113 FSYDLGRR-VETLPSRAKRDIEAPDMAVGLYEWAVVVDH-------------------QLKTAciVGNNIEQhhdwlMQQ 172
Cdd:PRK13567 105 CSFDLVRHeFPKLQSIQLEDHKQHDVRLYMVEQVYVFDHykdelyiiatnqfsnstksDLENR--VNKSIED-----LTK 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 173 LVQSKPTHAAFGLTTPWQSNMSEESYATKFDSVQEYLLSGDCYQI------NLAQRFNAQYQGSEWLAYDKLEQYNSAPF 246
Cdd:PRK13567 178 IQPFMPTQDFDFKTKEIQSNISEERFIEMIQYFKEKITEGDMFQVvpsriyKYAHHASQHLNQLSFQLYQNLKRQNPSPY 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 247 SGFIRLANCAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPG 326
Cdd:PRK13567 258 MYYLNIDQPYIVGSSPESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIG 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 327 TVHVPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNG 406
Cdd:PRK13567 338 TSKITKLMVIEKYEHVMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNH 417

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 880806243 407 RMDTSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPV 455
Cdd:PRK13567 418 NLDFALAIRTMMIDEQYINVEAGCGVVYDSIPEKELNETKLKAKSLLEV 466
PRK06404 PRK06404
anthranilate synthase component I; Reviewed
 185-453 7.69e-45

anthranilate synthase component I; Reviewed


Pssm-ID: 102361 [Multi-domain]  Cd Length: 351  Bit Score: 160.03  E-value: 7.69e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 185 LTTPWQSNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAydKLEQYNSAPFSGFIRLANCAIISVSPER 264
Cdd:PRK06404  94 KTVKLKGNYNDISLSLKIKELIELIRAGEVLQVVISREFEANIDFKEKLS--EFINNDRSRYVFYYRFGKYRVVGSSPEN 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 265 FLELKDNVIETKPIKGTRPrsddhviDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPAVHH 344
Cdd:PRK06404 172 VFTVNGNIINVDPIAGTYD-------DKILSNELLNSEKDKLEHRMLLDLARNDLSKFADIGTLNVDKVMKIEEFSSVKH 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 345 LVSTIRADLDDQySATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISrNGRMDTSITIRTLVAENNTL 424
Cdd:PRK06404 245 LVSQVTAKFSNA-SYRDILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIGIIS-KGYTDMALVIRTAYSHGNGF 322

                        250       260
                 ....*....|....*....|....*....
gi 880806243 425 YAWAGGGVVFDSDCASEYQETLDKLSRIL 453
Cdd:PRK06404 323 RVRAGAGIVKDSDPEDEVNEIYSKARSVM 351
PRK07093 PRK07093
para-aminobenzoate synthase component I; Validated
 189-448 4.55e-43

para-aminobenzoate synthase component I; Validated


Pssm-ID: 235932 [Multi-domain]  Cd Length: 323  Bit Score: 154.26  E-value: 4.55e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 189 WQSN-MSEESYATKFDSVQEYLLSGDCYQINLAQR--FNAQYQgsewlaydkLEQ---YNSAPF-----SGFIrlanCai 257
Cdd:PRK07093  66 LQKEpISFEEYQQGFELVQEEIQAGNSYLLNLTYPtpIETNLS---------LEEifqASKAKYkllfkDQFV----C-- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 258 isVSPERFLELKDNVIETKPIKGTRPRSddhvIDDANAQDLASaDKDQAENLMIVDLLRNDIGRVAKpgTVHVPKLFDIE 337
Cdd:PRK07093 131 --FSPEPFVRIEDNKISTYPMKGTIDAS----LPNAEEKLLND-EKEFAEHATIVDLLRNDLSMVAK--NVRVTRFRYID 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 338 SFPAVH----HLVSTIRADLDDQYSAT--DLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYIsrNGR-MDT 410
Cdd:PRK07093 202 KIKTNKgeilQTSSEISGTLPENWQENigDILAKLLPAGSITGAPKEKTVEIIEQAEGYERGFYTGVFGYF--DGEsLDS 279

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 880806243 411 SITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDK 448
Cdd:PRK07093 280 AVMIRFIEQENDGLYFKSGGGITIDSDLKDEYNELIQK 317
MenF COG1169
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ...
 256-457 2.25e-39

Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440783 [Multi-domain]  Cd Length: 353  Bit Score: 145.29  E-value: 2.25e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 256 AIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKpgTVHVPKLFD 335
Cdd:COG1169  152 GFVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDRREHALVVDSIREALAPLCS--SLDVPEEPE 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 336 IESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIR 415
Cdd:COG1169  230 LLRLRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALALIRELEPFDRGWYAGPVGWVDADGDGEFAVAIR 309

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 880806243 416 TLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLE 457
Cdd:COG1169  310 SALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRALG 351
PRK13566 PRK13566
anthranilate synthase component I;
108-458 2.01e-37

anthranilate synthase component I;


Pssm-ID: 237429 [Multi-domain]  Cd Length: 720  Bit Score: 145.44  E-value: 2.01e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 108 GALGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKTACIVGNNIEQHHdwlmqQLVQSKPTHAA---FG 184
Cdd:PRK13566 156 GLYGAFGYDLAFQFEPIEQKLPRPDDQRDLVLYLPDEILVVDHYAARAWVDRYEFAVGG-----VSTEGLPRETApspYK 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 185 LTTPWQ--SNMSEESYATKFDSVQEYLLSGDCYQINLAQRFNAQYQGSEWLAYDKLEQYNSAPFSGFIRLANCA-IISVS 261
Cdd:PRK13566 231 PTTARPgfADHAPGEYAALVEKAKESFRRGDLFEVVPGQTFYEPCERSPSEIFRRLKEINPSPYGFFINLGDGEyLVGAS 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 262 PERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKPGTVHVPKLFDIESFPA 341
Cdd:PRK13566 311 PEMFVRVEGRRVETCPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSVKVIGRRQIEMYSR 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 342 VHHLVSTIRADLDDQYSATD-LLRACFpGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSITIRTLVAE 420
Cdd:PRK13566 391 LIHTVDHVEGRLRPGFDALDaFLTHAW-AVTVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIK 469

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 880806243 421 NNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVLED 458
Cdd:PRK13566 470 DGVAEVRVGATLLFDSDPEAEEAETELKASALLQALRG 507
PRK07912 PRK07912
salicylate synthase;
237-456 1.14e-24

salicylate synthase;


Pssm-ID: 169151 [Multi-domain]  Cd Length: 449  Bit Score: 106.03  E-value: 1.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 237 KLEQYNSAPFSGFI-RLANCAIISVSPERFLELK-DNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDL 314
Cdd:PRK07912 224 RLGRRHNTPVRSFLlRLGGIRALGYSPELVTAVRaDGVVITEPLAGTRAFGRGAAIDRLARDDLESNSKEIVEHAISVRS 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 315 LRNDIGRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSA 394
Cdd:PRK07912 304 SLAEITEIAEPGSAAVIDFMTVRERGSVQHLGSTVRGRLDASSDRMDALEALFPAVTASGIPKAAGVDAIFRLDEAPRGL 383

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 880806243 395 YCGSIGYISRNGRMDTSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVL 456
Cdd:PRK07912 384 YSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLAPYL 445
PRK06923 PRK06923
isochorismate synthase DhbC; Validated
 257-456 1.03e-23

isochorismate synthase DhbC; Validated


Pssm-ID: 235886 [Multi-domain]  Cd Length: 399  Bit Score: 102.50  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 257 IISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIgrvaKP--GTVHVPKLF 334
Cdd:PRK06923 191 LIGASPELLVSRHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVEAVAAAL----RPycHTLHVPEKP 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 335 DIESFPAVHHLVSTIRADLDDQY-SATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMDTSIT 413
Cdd:PRK06923 267 SVIHTEAMWHLSTEVKGELKDPNtSSLELAIALHPTPAVCGTPTEEAREAIQQIEPFDREFFTGMLGWSDLNGDGEWIVT 346

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 880806243 414 IRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVL 456
Cdd:PRK06923 347 IRCAEVEENTLRLYAGAGVVAESKPEDELAETSAKFQTMLKAM 389
Anth_synt_I_N pfam04715
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) ...
 31-154 1.03e-22

Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).


Pssm-ID: 428082 [Multi-domain]  Cd Length: 140  Bit Score: 93.53  E-value: 1.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243   31 LPWAMLLRSASEShvDSRYDILVAQPIATFETIGAKTTVNVNETCEVSDSD-PFELLDQYQQQLLPVTKDHAELPFVGGA 109
Cdd:pfam04715  15 EPHSFLLESAEGG--EGRYSFIGINPLLTIKSKNGEVSVSGPDGQELEQEDgPLDALRALLARFRIEDSPPTLPPFSGGL 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 880806243  110 LGYFSYDLGRRVETLPSRAKRDIEAPDMAVGLYEWAVVVDHQLKT 154
Cdd:pfam04715  93 VGYLGYDLVRYIEKLPRTAPDDLNLPDARLILYEDLIVFDHQENK 137
PRK07054 PRK07054
isochorismate synthase;
250-450 1.02e-19

isochorismate synthase;


Pssm-ID: 235920 [Multi-domain]  Cd Length: 475  Bit Score: 91.36  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 250 IRLANCAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDIGRVAKpgTVH 329
Cdd:PRK07054 251 FRRGNACFLGATPERLVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVVDAIRAALAPLSR--ALD 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 330 VPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNGRMD 409
Cdd:PRK07054 329 IPDQPSLHRLPRLQHLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRAHEGFDRGWYAAPIGWLDAHGNGD 408

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 880806243 410 TSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLS 450
Cdd:PRK07054 409 FAVALRSALITGGACRLFAGCGIVADSEPASEYRETCLKLS 449
PRK06772 PRK06772
salicylate synthase;
240-456 6.26e-19

salicylate synthase;


Pssm-ID: 102546 [Multi-domain]  Cd Length: 434  Bit Score: 88.64  E-value: 6.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 240 QYNSAPFSGFIRLANCAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIVDLLRNDI 319
Cdd:PRK06772 217 QANTPVRSFMFRQEGREALGFSPELVMSVTGNKVVTEPLAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAEL 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 320 GRVAKPGTVHVPKLFDIESFPAVHHLVSTIRADLDDQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSI 399
Cdd:PRK06772 297 EAVCQPGSVVVEDLMSVRQRGSVQHLGSGVSGQLAENKDAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAI 376

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 880806243 400 GYISrNGRMDTSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVL 456
Cdd:PRK06772 377 LLLD-DTRFDAALVLRSVFQDSQRCWIQAGAGIIAQSTPERELTETREKLASIAPYL 432
PRK15016 PRK15016
isochorismate synthase EntC; Provisional
 236-456 2.03e-17

isochorismate synthase EntC; Provisional


Pssm-ID: 184977 [Multi-domain]  Cd Length: 391  Bit Score: 83.77  E-value: 2.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 236 DKLEQYNSAPFSGFIRLAN-CAIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENLMIV-- 312
Cdd:PRK15016 169 ERLIAQNPVSYNFHVPLADgGVLLGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTqa 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 313 --DLLRNDIGRVAKPGTvhvPKLFdieSFPAVHHLVSTIRADLDDQYSATDLlrACF--PGGSITGAPKVRAMQIIEELE 388
Cdd:PRK15016 249 mkEVLRERSSELHVPSS---PQLI---TTPTLWHLATPFEGKANAQENALTL--ACLlhPTPALSGFPHQAAKQVIAELE 320

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 880806243 389 PHRRSAYCGSIGYISRNGRMDTSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDKLSRILPVL 456
Cdd:PRK15016 321 PFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVF 388
PLN02786 PLN02786
isochorismate synthase
 231-451 1.61e-16

isochorismate synthase


Pssm-ID: 178383 [Multi-domain]  Cd Length: 533  Bit Score: 81.75  E-value: 1.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 231 EWLAYDKLEQYNSAPFsgFIRLANC-AIISVSPERFLELKDNVIETKPIKGTRPRSDDHVIDDANAQDLASADKDQAENL 309
Cdd:PLN02786 301 AWLACLQVEGQNAYQF--CLQPPDApAFIGNTPEQLFHRKGLGVCSEALAATRPRGGSSARDLQIELDLLTSPKDDLEFS 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 310 MIVDLLRNDIGRVAKPGTVHVPKlfDIESFPAVHHLVSTIRADL---DDQYsatDLLRACFPGGSITGAPKVRAMQIIEE 386
Cdd:PLN02786 379 IVRENIREKLEAICDRVVVEPHK--AIRKLARVQHLYAQLAGRLrseDDEF---DILAALHPTPAVCGHPTEEARLLIAE 453

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 880806243 387 LEPHRRSAYCGSIGYISrNGRMDTSITIRTLVAENN-TLYAWAGGGVVFDSDCASEYQETLDKLSR 451
Cdd:PLN02786 454 TESFDRGMYAGPVGWFG-GGESEFAVGIRSALVEKGlGALIYAGTGIVEGSNPSSEWNELELKISQ 518
PRK15012 PRK15012
menaquinone-specific isochorismate synthase; Provisional
 253-448 2.34e-13

menaquinone-specific isochorismate synthase; Provisional


Pssm-ID: 184974 [Multi-domain]  Cd Length: 431  Bit Score: 71.41  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 253 ANCAIISVSPERFLELKDNVIETKPIKGTRPrsdDHViDDANAQDLA----SADKDQAENLMIVDLLRNDIGRVAKPGTV 328
Cdd:PRK15012 230 AENAFLGSSPERLWRRRDKALRTEALAGTVA---NHP-DDKQAQQLGewlmADDKNQRENMLVVEDICQRLQADTQTLDV 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806243 329 HVPKLFDIESfpaVHHLVSTIRADLDdQYSATDLLRACFPGGSITGAPKVRAMQIIEELEPHRRSAYCGSIGYISRNgRM 408
Cdd:PRK15012 306 LPPQVLRLRK---VQHLRRCIWTSLN-KADDVICLHQLQPTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQ-QS 380

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 880806243 409 DTSITIRTLVAENNTLYAWAGGGVVFDSDCASEYQETLDK 448
Cdd:PRK15012 381 EFCVSLRSAKVSGNVVRLYAGAGIVRGSDPEQEWQEIDNK 420
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH