NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|880806352|ref|WP_048658530|]
View 

MULTISPECIES: vitamin B12 ABC transporter permease BtuC [Vibrio]

Protein Classification

vitamin B12 ABC transporter permease BtuC( domain architecture ID 10792326)

vitamin B12 ABC transporter permease BtuC is part of the BtuCDF ABC transporter complex involved the import of vitamin B12

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 1-331 2.09e-151

vtamin B12-transporter permease; Provisional


:

Pssm-ID: 235159  Cd Length: 331  Bit Score: 428.22  E-value: 2.09e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   1 MDFQQLLHQKQRKWTRAIYLMTALLVTLSAIYLMVGDLFISPLDTLSTLEQKLLIDLRLPRLLAAIAIGAGLAVSGASLQ 80
Cdd:PRK03784   1 MSMLTLARQQQRRNRRWLLGLSVLLLLALLLSLCAGEQWISPGDWLSPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  81 VLLGNVLAEPGVLGISGGASLAMVIVLFFLPFAPTPELFMIAAVLGSLCFTVILVSMVKTMRLTTAKLLLVGVALGILSG 160
Cdd:PRK03784  81 ALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 161 AMVTWAFYFSDDLSLRLLMYWLMGSLGGVTWYQHSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIF 240
Cdd:PRK03784 161 ALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLMLALLPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 241 AVSILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIF 320
Cdd:PRK03784 241 ATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVF 320

                        330
                 ....*....|.
gi 880806352 321 IWMLIKNHDSN 331
Cdd:PRK03784 321 IWLLLRSHRAR 331
 
Name Accession Description Interval E-value
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 1-331 2.09e-151

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 428.22  E-value: 2.09e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   1 MDFQQLLHQKQRKWTRAIYLMTALLVTLSAIYLMVGDLFISPLDTLSTLEQKLLIDLRLPRLLAAIAIGAGLAVSGASLQ 80
Cdd:PRK03784   1 MSMLTLARQQQRRNRRWLLGLSVLLLLALLLSLCAGEQWISPGDWLSPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  81 VLLGNVLAEPGVLGISGGASLAMVIVLFFLPFAPTPELFMIAAVLGSLCFTVILVSMVKTMRLTTAKLLLVGVALGILSG 160
Cdd:PRK03784  81 ALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 161 AMVTWAFYFSDDLSLRLLMYWLMGSLGGVTWYQHSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIF 240
Cdd:PRK03784 161 ALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLMLALLPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 241 AVSILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIF 320
Cdd:PRK03784 241 ATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVF 320

                        330
                 ....*....|.
gi 880806352 321 IWMLIKNHDSN 331
Cdd:PRK03784 321 IWLLLRSHRAR 331
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 4-330 1.19e-123

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 357.63  E-value: 1.19e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   4 QQLLHQKQRKWTRAIYLMTALLVTLSAIYLMVGDLFISPLDTLSTLEQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLL 83
Cdd:COG4139    1 MQLPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLSEAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  84 GNVLAEPGVLGISGGASLAMVIVLFFLPFAPTPELFMIAAVLGSLCFTVILVSMVKTmRLTTAKLLLVGVALGILSGAMV 163
Cdd:COG4139   81 ENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLAAIAGALLVTLLLLAFARR-RLSNARLLLIGVALGIICSAIM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 164 TWAFYFSDDLSLRLLMYWLMGSLGGVTWYQHSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIFAVS 243
Cdd:COG4139  160 TWAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 244 ILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIFIWM 323
Cdd:COG4139  240 LLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWL 319


                 ....*..
gi 880806352 324 LIKNHDS 330
Cdd:COG4139  320 LLRRRKI 326
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 24-326 9.99e-67

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 212.00  E-value: 9.99e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   24 LLVTLSAIYLMVGDLFISPLDTLSTL-------EQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPGVLGIS 96
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALlggddslAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   97 GGASLAMVIVLFFLPFAPTPELfMIAAVLGSLCFTVILVSMVKTMR-LTTAKLLLVGVALGILSGAMVTWAFYFSDDLSL 175
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFAL-PLAAFIGALLAALLVYFLSRGRGgASPLRLILAGIAVSALLSALTSLLLLLLNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  176 RLLMYWLMGSLGGVTWYQ-HSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIFAVSILVGCAVALGG 254
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDvLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 880806352  255 VISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIFIWMLIK 326
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 74-324 9.92e-47

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 158.87  E-value: 9.92e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  74 VSGASLQVLLGNVLAEPGVLGISGGASLAMVIVLFFLPFAPTPeLFMIAAVLGSLCFTVILVSMVKTMRLTTAKLLLVGV 153
Cdd:cd06550   13 VSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNY-ALGAFAFAGALAIALLVLLLASRGGLSPSKLILIGI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 154 ALGILSGAMVTWAFYFSDDLSLRLlMYWLMGSLGGVTWYQHSLTL-VMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVP 232
Cdd:cd06550   92 VLSAFFSAGVILISLLSDDSLQDL-NIWLFGSILGVTWEDLLILLiILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVN 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 233 RLRWRLIFAVSILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSaELPLGVMT 312
Cdd:cd06550  171 LLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLLPS-ELPVGPVT 249

                        250
                 ....*....|..
gi 880806352 313 TSIGAPIFIWML 324
Cdd:cd06550  250 ALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 1-331 2.09e-151

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 428.22  E-value: 2.09e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   1 MDFQQLLHQKQRKWTRAIYLMTALLVTLSAIYLMVGDLFISPLDTLSTLEQKLLIDLRLPRLLAAIAIGAGLAVSGASLQ 80
Cdd:PRK03784   1 MSMLTLARQQQRRNRRWLLGLSVLLLLALLLSLCAGEQWISPGDWLSPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  81 VLLGNVLAEPGVLGISGGASLAMVIVLFFLPFAPTPELFMIAAVLGSLCFTVILVSMVKTMRLTTAKLLLVGVALGILSG 160
Cdd:PRK03784  81 ALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCAIAGALLITLILLRFARRHRLSTSRLLLAGVALGIICS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 161 AMVTWAFYFSDDLSLRLLMYWLMGSLGGVTWYQHSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIF 240
Cdd:PRK03784 161 ALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWRQSWLMLALLPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 241 AVSILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIF 320
Cdd:PRK03784 241 ATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVF 320

                        330
                 ....*....|.
gi 880806352 321 IWMLIKNHDSN 331
Cdd:PRK03784 321 IWLLLRSHRAR 331
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 4-330 1.19e-123

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 357.63  E-value: 1.19e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   4 QQLLHQKQRKWTRAIYLMTALLVTLSAIYLMVGDLFISPLDTLSTLEQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLL 83
Cdd:COG4139    1 MQLPQRQRRRDRRWLLLLLLLLLLLFVLSLCAGEVWIPPTQWLSEAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  84 GNVLAEPGVLGISGGASLAMVIVLFFLPFAPTPELFMIAAVLGSLCFTVILVSMVKTmRLTTAKLLLVGVALGILSGAMV 163
Cdd:COG4139   81 ENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLAAIAGALLVTLLLLAFARR-RLSNARLLLIGVALGIICSAIM 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 164 TWAFYFSDDLSLRLLMYWLMGSLGGVTWYQHSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIFAVS 243
Cdd:COG4139  160 TWAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWLLLALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 244 ILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIFIWM 323
Cdd:COG4139  240 LLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWL 319


                 ....*..
gi 880806352 324 LIKNHDS 330
Cdd:COG4139  320 LLRRRKI 326
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 33-326 1.33e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 244.59  E-value: 1.33e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  33 LMVGDLFISPLDTLSTL--------EQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPGVLGISGGASLAMV 104
Cdd:COG0609    2 LSLGAVPISLSDVLRALlgpdgdptADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 105 IVLFFLPFAPtPELFMIAAVLGSL--CFTVILVSMvKTMRLTTAKLLLVGVALGILSGAMVTWAFYFSDDLSLRLLMYWL 182
Cdd:COG0609   82 LAIVLGGGLS-ALGLPLAAFLGALlaALLVYLLAR-RGGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 183 MGSLGGVTWYQ-HSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIFAVSILVGCAVALGGVISFVGL 261
Cdd:COG0609  160 MGSLAGASWDDvLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 880806352 262 VVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIFIWMLIK 326
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRR 304
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 24-326 9.99e-67

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 212.00  E-value: 9.99e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   24 LLVTLSAIYLMVGDLFISPLDTLSTL-------EQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPGVLGIS 96
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALlggddslAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352   97 GGASLAMVIVLFFLPFAPTPELfMIAAVLGSLCFTVILVSMVKTMR-LTTAKLLLVGVALGILSGAMVTWAFYFSDDLSL 175
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFAL-PLAAFIGALLAALLVYFLSRGRGgASPLRLILAGIAVSALLSALTSLLLLLLNPEAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  176 RLLMYWLMGSLGGVTWYQ-HSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIFAVSILVGCAVALGG 254
Cdd:pfam01032 160 QSILFWLMGSLSGANWSDvLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVG 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 880806352  255 VISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIFIWMLIK 326
Cdd:pfam01032 240 PIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
12-326 2.49e-48

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 171.95  E-value: 2.49e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  12 RKWTRAIYLMTALLVTLSAIYLMVGDLfISPLDTLSTLEQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPG 91
Cdd:PRK10577 352 RRVLAWLLALGLLLLLALVVALSFGRD-AHGWNWLSGQLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPE 430

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  92 VLGISGGASLAMVIVLFFLPfAPTPELFMIAAVLGSLCFTVILVSMVKTMRLTTAKLLLVGVALGILSGAMVTWAFYFSD 171
Cdd:PRK10577 431 VLGISSGAGLGVVLALFLVP-GAGFGWLLAAALLGALAALALILLLARRGGFAPERLLLTGIALSALFTALIQLLLASGD 509

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 172 DLSLRLLMyWLMGSLGGVTWYQHSLTLVMIPVIIWLCLQGSK-LDKLMIGETHAAQLGVNVPRLRWRLIFAVSILVGCAV 250
Cdd:PRK10577 510 PRAAQLLT-WLSGSTYGVTWAQALPLLIVAVLLLALALLLRRwLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAAT 588

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 880806352 251 ALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIFIWMLIK 326
Cdd:PRK10577 589 ATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRR 664
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 74-324 9.92e-47

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 158.87  E-value: 9.92e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  74 VSGASLQVLLGNVLAEPGVLGISGGASLAMVIVLFFLPFAPTPeLFMIAAVLGSLCFTVILVSMVKTMRLTTAKLLLVGV 153
Cdd:cd06550   13 VSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNY-ALGAFAFAGALAIALLVLLLASRGGLSPSKLILIGI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 154 ALGILSGAMVTWAFYFSDDLSLRLlMYWLMGSLGGVTWYQHSLTL-VMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVP 232
Cdd:cd06550   92 VLSAFFSAGVILISLLSDDSLQDL-NIWLFGSILGVTWEDLLILLiILLLVLLLLLLLSRKLNLLTFDEDLAKSLGINVN 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 233 RLRWRLIFAVSILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSaELPLGVMT 312
Cdd:cd06550  171 LLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLLPS-ELPVGPVT 249

                        250
                 ....*....|..
gi 880806352 313 TSIGAPIFIWML 324
Cdd:cd06550  250 ALLGAPYFLYLL 261
btuC PRK09535
cobalamin ABC transporter permease BtuC;
51-327 1.02e-45

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 159.15  E-value: 1.02e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  51 QKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPGVLGISGGASLAMVIVLFF---LPFAPTPELFMIAAVLGs 127
Cdd:PRK09535  88 QTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIVLplaVPFGLQAAAFAGALVAA- 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 128 lcFTVILVSmVKTMRLTTAKLLLVGVALGILSGAMVTWAFYFSDDlSLRLLMYWLMGSLGGVTWYQHSLTLVMIPVIIWL 207
Cdd:PRK09535 167 --FGVYAIA-TENGRTPVATLLLAGVAVQTFLGAVISYLLLHSGE-SLRRAVYWLMGHLHGSTWSDVEVALPVVVVGFVV 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 208 CLQGSK-LDKLMIGETHAAQLGVNVPRLRWRLIFAVSILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAG 286
Cdd:PRK09535 243 LLAYARdLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAG 322

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 880806352 287 AALLVFADICARTllDSAELPLGVMTTSIGAPIFIWMLIKN 327
Cdd:PRK09535 323 ASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLRTR 361
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
40-323 6.08e-41

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 145.61  E-value: 6.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  40 ISPLDTLS--------TLEQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPGVLGISGGASLAMVIVLFFLP 111
Cdd:PRK11228  25 ISAADALNallpghtpTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINSGAALAMALTSALSP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 112 -FAPTPELFMIAAVLGSLCF-TVILVSMVKTMRLTTAKLLLVGVALGILSGAMVTWAFYFSDDLSLRLlMYWLMGSLGGV 189
Cdd:PRK11228 105 tPFAGYSLAFIAACGGGLSWlLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRITLLLAEDHAYGI-FYWLAGGVSHA 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 190 TWYQHSL----TLVMIPVIIWLclqGSKLDKLMIGETHAAQLGVNVPRLRWRLIFAVSILVGCAVALGGVISFVGLVVPH 265
Cdd:PRK11228 184 RWQEVWQllpfVVTAVPVVLLL---ANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGPVAFIGLLVPH 260

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 880806352 266 LLRLAIGTDNKYLLPLSAVAGAALLVFADICARTLLDSAELPLGVMTTSIGAPIFIWM 323
Cdd:PRK11228 261 LARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWL 318
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
54-326 2.44e-38

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 138.26  E-value: 2.44e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  54 LIDLRLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPGVLGISGGASLAMVIVLFFLPFAPTPELFMIAAVlGSLCFTVI 133
Cdd:PRK09777  47 LMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSLPVMWLPLLAFI-GGMAGLIL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 134 LVSMVKTMRltTAKLLLVGVALGILSgAMVTWAFYFSDDLSLRLLMYWLMGSLGGVTWYQHSLTL----VMIPVIIWLCl 209
Cdd:PRK09777 126 LKMLAGTHQ--PMKLALTGVALSALW-ASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVALpwliLLLPLSLSFC- 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 210 qgSKLDKLMIGETHAAQLGVNVPRLR-WRLIFAVSiLVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAA 288
Cdd:PRK09777 202 --RDLDLLALGDARATTLGVSVPHTQfWALLLAVA-LTATGVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGAL 278

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 880806352 289 LLVFADICARTLLDSAELPLGVMTTSIGAPIFIWMLIK 326
Cdd:PRK09777 279 LLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVR 316
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
12-324 2.79e-35

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 135.35  E-value: 2.79e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  12 RKWTRAIYLMTALLVTLSAIYLMVGDLFISPLDTLSTL--------EQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLL 83
Cdd:PRK10577   8 RRARLPALLLALLLLLALALTLTQLSAALPLSQWLQALwgpdaddlEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  84 GNVLAEPGVLGISGGASLAMVIVLFFLPfaPTPELF-MIAAVLGSLCFTVILVSMVKTMRLTTAKLLLVGVALGILSGAM 162
Cdd:PRK10577  88 RNPLASPTTLGVAAGAQLALVLATLFAP--ALLALAsQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGAL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 163 VTWAFYFSDDlSLRLLMYWLMGSLGGVTWYQ-HSLTLVMIPVIIWLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIFA 241
Cdd:PRK10577 166 TTLLLLFNEQ-YLQGLFLWGAGSLAQNDWSGvQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALAL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 242 VSILVGCAVALGGVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARTL--LDSAELPLGVMTTSIGAPI 319
Cdd:PRK10577 245 AVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLagVGGELLPTGAVTALIGAPL 324


                 ....*
gi 880806352 320 FIWML 324
Cdd:PRK10577 325 LLWLL 329
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
20-328 5.13e-29

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 114.03  E-value: 5.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  20 LMTALLVTLSAIYLMVGDLFISPLDTLSTLEQKLLIDLRLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPGVLGISGGA 99
Cdd:PRK10441  22 IATALSLLIGAKSLPASVVLEALSGTCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 100 SLAMVIVLFFLPFAPTPElFMIAAVLGSLCFTVI--LVSMVKTMRLTTAKLLLVGVALG-ILSGAmvTWAFYFSDDLSLR 176
Cdd:PRK10441 102 SFAIVLGAALFGYSSAQE-QLAMAFAGALVASLIvaFTGSQGGGQLSPVRLTLAGVALAaVLEGL--TSGIALLNPDVYD 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 177 LLMYWLMGSLGGVTwyQHSLTLVMIPVII---WLCLQGSKLDKLMIGETHAAQLGVNVPRLRWRLIFAVSILVGCAVALG 253
Cdd:PRK10441 179 QLRFWQAGSLDIRN--LHTLKVVLIPVLIagaTALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVV 256

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 880806352 254 GVISFVGLVVPHLLRLAIGTDNKYLLPLSAVAGAALLVFADICARtLLDSAELPLGVMTTSIGAPIFIWMLIKNH 328
Cdd:PRK10441 257 GPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGR-LLVPGELRVSVVSAFIGAPVLIFLVRRKT 330
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
58-326 2.22e-22

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 95.55  E-value: 2.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352  58 RLPRLLAAIAIGAGLAVSGASLQVLLGNVLAEPGVLGISGGA--SLAMVIVLFflpfapTPELFMIA--AVLGSLCFTVI 133
Cdd:PRK10440  59 RLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAwsGVLVAMVLF------GQDLTAIAlaAMAGGIVTSLL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 134 LVSMVKTMRLTTAKLLLVGVALGILSGAMVTWAFYFSDDLSLRLLMYWLMGSLGGVTWyqhSLTLVMIPVIIWLCLQGSK 213
Cdd:PRK10440 133 VWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGLWNAGSLNGLTW---AKTSPSAPIIILMLIAAAL 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880806352 214 LDKLM----IGETHAAQLGVNVPRLRWRLIFAVSILVGCAVALGGVISFVGLVVPHLLRLAIGTdNKYLLPLSAVAGAAL 289
Cdd:PRK10440 210 LVRRMrlleMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLSGT-ARWGLTQAALCGALL 288

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 880806352 290 LVFADICARTLLDSAELPLGVMTTSIGAPIFIWMLIK 326
Cdd:PRK10440 289 LLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQ 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH