|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
164-486 |
1.15e-82 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 261.03 E-value: 1.15e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 164 IALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVTPHPVTTEVGSLALSL 243
Cdd:COG5002 65 LLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 244 NTMLTQVEQSFEARQASEQKIKRFVSDASHELRTPLAAISGYCELYAMGGV-PAERTDEVMGRIASESSRMATLVEDLLT 322
Cdd:COG5002 145 LLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAAdDPEERREYLEIILEEAERLSRLVNDLLD 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 323 LARLDEGR-PLDITDIDLVKLADNAVFDLQALDPTRTVGLTGISGRTPPMtliIPGDRDRISQVFTNLIGNIVRYTPEGS 401
Cdd:COG5002 225 LSRLESGElKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLL---VLGDPDRLEQVLTNLLDNAIKYTPEGG 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 402 PVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTV 481
Cdd:COG5002 302 TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTF 381
|
....*
gi 880920401 482 RIELP 486
Cdd:COG5002 382 TITLP 386
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
157-486 |
5.48e-68 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 220.94 E-value: 5.48e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 157 QFSGYMTIALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVTPHPVTTEV 236
Cdd:COG0642 4 LLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 237 GSLALSLNTMLTQVEQSFEARQASEQKiKRFVSDASHELRTPLAAISGYCELYAMGgvPAERTDEVMGRIASESSRMATL 316
Cdd:COG0642 84 LLLLLLLLLLLLLLALLLLLEEANEAK-SRFLANVSHELRTPLTAIRGYLELLLEE--LDEEQREYLETILRSADRLLRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 317 VEDLLTLARLDEGR-PLDITDIDLVKLADNAVFDLQALDPTRTVGLTGisgRTPPMTLIIPGDRDRISQVFTNLIGNIVR 395
Cdd:COG0642 161 INDLLDLSRLEAGKlELEPEPVDLAELLEEVVELFRPLAEEKGIELEL---DLPDDLPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 396 YTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSrnRKSGGSGLGLAIVSGILAAHRGNASLSKTK 475
Cdd:COG0642 238 YTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEP 315
|
330
....*....|.
gi 880920401 476 GGGLTVRIELP 486
Cdd:COG0642 316 GKGTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
249-486 |
1.07e-67 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 217.08 E-value: 1.07e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 249 QVEQSFEARQASEQKIKRFVSDASHELRTPLAAISGYCELYAMG-GVPAERTDEVMGRIASESSRMATLVEDLLTLARLD 327
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 328 EGR-PLDITDIDLVKLADNAVFDLQALDPTRTVGltgISGRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIA 406
Cdd:COG2205 81 SGKlSLELEPVDLAELLEEAVEELRPLAEEKGIR---LELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITIS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 407 LGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRksGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGE--GGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
18-470 |
7.05e-54 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 187.59 E-value: 7.05e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 18 LSSQLVTLITSLLAVGLSLSGTVMIGLLQRHLTSQIDDQLIA----TAHTLQISASTATFSADGQGGIPTLYY----IHI 89
Cdd:TIGR01386 4 LTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGkleqVRRFLRDPADLDEDIKRLQEKIDDLLVghsdLAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 90 RNTDGTDRYFYSEdtlkvSGKPDLPDLVDTSSAP-ISSFRTLPITVSSSkaglgwRALVVPVYEQDSGQFSGYMTIALPL 168
Cdd:TIGR01386 84 SILNPDGRLLFER-----AQGAALVPAVAANDALlELDQADAKMTHYRS------ILRSVAALPGGKGRKPVQITVALDI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 169 SDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVTPHPVTTEVGSLALSLNTMLT 248
Cdd:TIGR01386 153 NAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 249 QVEQSFearqaseQKIKRFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVMGRIASESSRMATLVEDLLTLARLDE 328
Cdd:TIGR01386 233 RLEDAF-------QRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 329 GR-PLDITDIDLVKLADNAVFDLQALDPTRTVGLTgISGrtppmTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIAL 407
Cdd:TIGR01386 306 GQlALERVRLDLAAELAKVAEYFEPLAEERGVRIR-VEG-----EGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRI 379
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 880920401 408 GRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNAS 470
Cdd:TIGR01386 380 ERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRAS 442
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
22-486 |
1.73e-50 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 179.45 E-value: 1.73e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 22 LVTLITSLLAV---GLSLSGTVMIGLLQRHLTSQIDDQLIATAHTL-QISASTATFSADGQ---------------GGIP 82
Cdd:NF040691 11 AITLLLSLVVIlvlGVVLALQITNGLLDNRVDAALGDSRRARTQAQsQLNASDASTSDSAQqllrttllsvlasasGAMQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 83 TLYYIHIRNTDGTDRYFYSEDTLKVSGKPDLPD-LVDTSSAPISSFRTLPITVSSSkAGLGWRALVV--PVYEQDSGQFS 159
Cdd:NF040691 91 GAFDVVLLVPGDDPSGLGPRASGSVGLVSQIPEeLREAVAGGQVAQQYQSVALPSG-DGSSAPALVVgtPVTLPVAGNYE 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 160 GYmtIALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVtphPVTTE--VG 237
Cdd:NF040691 170 LY--LLFPLEDEQSTLALVRGTLLLGGLALVVLLGLIAWLVTRQVVAPVRSAARTAERFAAGDLSERM---PVKGEddLA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 238 SLALSLNTMLTQVEQSFEARQASEQKIKRFVSDASHELRTPLAAISGYCELYAMGGV---PA-ERTDEVMgriASESSRM 313
Cdd:NF040691 245 RLARSFNQMADSLQRQIRQLEELSRLQQRFVSDVSHELRTPLTTIRMAADVIHDSRDdfdPAtARSAELL---HTELDRF 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 314 ATLVEDLLTLARLDEGRP-LDITDIDLVKLADNAVFDLQALDPTRTVGLTgisGRTPPMTLIIPGDRDRISQVFTNLIGN 392
Cdd:NF040691 322 ESLLSDLLEISRFDAGAAeLDVEPVDLRPLVRRVVDALRQLAERAGVELR---VDAPGTPVVAEVDPRRVERVLRNLVVN 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 393 IVRYTpEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLS 472
Cdd:NF040691 399 AIEHG-EGKPVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAW 477
|
490
....*....|....
gi 880920401 473 KTKGGGLTVRIELP 486
Cdd:NF040691 478 GRPGQGSQFRLTLP 491
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
200-486 |
2.43e-49 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 175.59 E-value: 2.43e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 200 LVRRALL-PL-RSIESTAgKIAAGDLTKRVTPHPvTTEVGSLALSLNTMLTQVEQSFEARQAseqkikrFVSDASHELRT 277
Cdd:PRK10549 183 LLARGLLaPVkRLVEGTH-KLAAGDFTTRVTPTS-RDELGRLAQDFNQLASTLEKNEQMRRD-------FMADISHELRT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 278 PLAAISGycELYAM-GGVpAERTDEVMGRIASESSRMATLVEDLLTLARLDEG------RPLDItdIDLVKLADNAVFD- 349
Cdd:PRK10549 254 PLAVLRG--ELEAIqDGV-RKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGalayrkTPVDL--VPLLEVAGGAFREr 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 350 LQALDPTRTVGLtgisgrtPPMTLIIpGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETD 429
Cdd:PRK10549 329 FASRGLTLQLSL-------PDSATVF-GDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQ 400
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 880920401 430 RGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:PRK10549 401 LQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
267-467 |
5.64e-49 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 171.24 E-value: 5.64e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 267 FVSDASHELRTPLAAISGYCE-LYAMGGVPAERTDEVMGRIASESSRMATLVEDLLTLARL-DEGRPLDITDIDLVKLAD 344
Cdd:TIGR02966 117 FVANVSHELRTPLTVLRGYLEtLADGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLeSAASPLEDEPVDMPALLD 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 345 NAVFDLQALDPTRTVGLTGISGrtppMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPG 424
Cdd:TIGR02966 197 HLRDEAEALSQGKNHQITFEID----GGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGAEFSVTDTGIG 272
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 880920401 425 IDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRG 467
Cdd:TIGR02966 273 IAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHA 315
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
200-486 |
1.37e-45 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 165.39 E-value: 1.37e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 200 LVRRALL-PLRSIESTAGKIAAGDLTKRVTPHPvTTEVGSLALSLNTMLTQVEQSFEARQAseqkikrFVSDASHELRTP 278
Cdd:NF012163 183 LLARGLLaPVKRLVEATHRLAAGDYTTRVTPTS-NDELGKLAQDFNQLASTLEKNEQMRRD-------FMADISHELRTP 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 279 LAAISGycELYAMGGVPAERTDEVMGRIASESSRMATLVEDLLTLARLDEGR-PLDITDIDLVKLADNAVFDLQALDPTR 357
Cdd:NF012163 255 LAVLRA--ELEAIQDGIRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGAlAYQKASVDLVPLLEVEGGAFRERFASA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 358 TVGLTgISGrtpPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERF 437
Cdd:NF012163 333 GLELE-VSL---PDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERF 408
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 880920401 438 YRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:NF012163 409 YRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
162-486 |
1.45e-44 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 163.42 E-value: 1.45e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 162 MTIALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVTphpVTTEVGSLAL 241
Cdd:COG4251 183 LLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLI---LVLELLELRL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 242 SLNTMLTQVEQSFEARQASEQKIKRFVSDASHELRTPLAAISGYCELYAM--GGVPAERTDEVMGRIASESSRMATLVED 319
Cdd:COG4251 260 ELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEdyGDKLDEEGREYLERIRDAAERMQALIDD 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 320 LLTLARLDEgRPLDITDIDLVKLADNAVFDLQALDPTRTVGLTgisgrTPPMtLIIPGDRDRISQVFTNLIGNIVRYTPE 399
Cdd:COG4251 340 LLAYSRVGR-QELEFEPVDLNELLEEVLEDLEPRIEERGAEIE-----VGPL-PTVRGDPTLLRQVFQNLISNAIKYSRP 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 400 GSPVEIALG--RSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRksGGSGLGLAIVSGILAAHRGNASLSKTKGG 477
Cdd:COG4251 413 GEPPRIEIGaeREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGE 490
|
....*....
gi 880920401 478 GLTVRIELP 486
Cdd:COG4251 491 GATFYFTLP 499
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
149-487 |
2.29e-41 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 153.85 E-value: 2.29e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 149 PVYeqDSGQFSGYMTIALPLSDMQ----HTLRTTASYFAVAGSIIVLIGGWTGRVLVRrallPLRSIESTAGKIAAGdlt 224
Cdd:PRK11100 153 PIR--DGGRIIGVLSVGKPNSSMApfikRSERRILWAGALLLGIALLIGAGVVWWLNR----SIRRLTRYADAVTEG--- 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 225 KRVT-PHPVTTEVGSLALSLNTMLTQVEqsfearqaSEQKIKRFVSDASHELRTPLAAISGYCELYAmGGVPAERTDEVM 303
Cdd:PRK11100 224 KPVPlPKLGSSELRELAQALESMRVKLE--------GKAYVEQYVQTLTHELKSPLAAIRGAAELLQ-EDPPPEDRARFT 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 304 GRIASESSRMATLVEDLLTLARLdEGR--PLDITDIDLVKLADNAVFDLQALDPTRTVGLtgisgRTPPMTLIIPGDRDR 381
Cdd:PRK11100 295 GNILTQSARLQQLIDRLLELARL-EQRqeLEVLEPVALAALLEELVEAREAQAAAKGITL-----RLRPDDARVLGDPFL 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFY---RADSSrnRKSggSGLGLAIV 458
Cdd:PRK11100 369 LRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANG--RKS--TGLGLAFV 444
|
330 340
....*....|....*....|....*....
gi 880920401 459 SGILAAHRGNASLSKTKGGGLTVRIELPT 487
Cdd:PRK11100 445 REVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
143-472 |
3.13e-40 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 151.08 E-value: 3.13e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 143 WRALVVPVYEQDSGQFSGYMTIALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGD 222
Cdd:PRK09835 148 WRMIALPVGPLVDGKPIYTLLIALSIDFHLHYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKD 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 223 LTKRVTPHPVTTEVGSLALSLNTMLTQVEQSFeARQASeqkikrFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEV 302
Cdd:PRK09835 228 LDVRLDPQTVPIELEQLVLSFNHMIERIEDVF-TRQSN------FSADIAHEIRTPITNLITQTEIALSQSRSQKELEDV 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 303 MGRIASESSRMATLVEDLLTLARLDEGR------PLDITDiDLVKladnaVFDL-QALDPTRTVGLtgisgRTPPMTLII 375
Cdd:PRK09835 301 LYSNLEELTRMAKMVSDMLFLAQADNNQlipekkMLDLAD-EVGK-----VFDFfEAWAEERGVEL-----RFVGDPCQV 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 376 PGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGL 455
Cdd:PRK09835 370 AGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGL 449
|
330
....*....|....*..
gi 880920401 456 AIVSGILAAHRGNASLS 472
Cdd:PRK09835 450 AIVKSIVVAHKGTVAVT 466
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
182-488 |
4.26e-40 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 149.34 E-value: 4.26e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 182 FAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVtphPVTT--EVGSLALSLNTMLTQVEQSF---EA 256
Cdd:COG5000 11 LLLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRL---PVTGddEIGELARAFNRMTDQLKEQReelEE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 257 RQASEQKIKRFVSDA----------------------------------------------------------------- 271
Cdd:COG5000 88 RRRYLETILENLPAGvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgr 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 272 -----------------------------------------SHELRTPLAAISGYCE-----LYAMGGVPAERTDEVMGR 305
Cdd:COG5000 168 rtllvrasplrddgyvivfdditellraerlaawgelarriAHEIKNPLTPIQLSAErlrrkLADKLEEDREDLERALDT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 306 IASESSRMATLVEDLLTLARLdegRPLDITDIDLVKLADNAVFDLQALDPTRTVGLTGisgRTPPMTLIIPGDRDRISQV 385
Cdd:COG5000 248 IIRQVDRLKRIVDEFLDFARL---PEPQLEPVDLNELLREVLALYEPALKEKDIRLEL---DLDPDLPEVLADRDQLEQV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 386 FTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYradSSrnrKSGGSGLGLAIVSGILAAH 465
Cdd:COG5000 322 LINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF---TT---KPKGTGLGLAIVKKIVEEH 395
|
410 420
....*....|....*....|...
gi 880920401 466 RGNASLSKTKGGGLTVRIELPTT 488
Cdd:COG5000 396 GGTIELESRPGGGTTFTIRLPLA 418
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
208-487 |
1.54e-39 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 148.21 E-value: 1.54e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 208 LRSIESTAGKIAAGDLTKRvTPHPVTTEVGSLALSLNTMLTQVEQSFEARqaseqkiKRFVSDASHELRTPLAAISgyce 287
Cdd:PRK10604 164 MLKLEAAAQRLGDGHLAER-IHFDEGSSLERLGVAFNQMADNINALIASK-------KQLIDGIAHELRTPLVRLR---- 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 288 lYAMGGVPAERTDEVMGrIASESSRMATLVEDLLTLARLDegRP---LDITDIDLVKLADNAVFDLQALDPTRTVGLTgi 364
Cdd:PRK10604 232 -YRLEMSDNLSAAESQA-LNRDIGQLEALIEELLTYARLD--RPqneLHLSEPDLPAWLSTHLADIQAVTPEKTVRLD-- 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 365 sgrTPPMTLIIPGDRDRISQVFTNLIGNIVRYTpeGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSR 444
Cdd:PRK10604 306 ---TPHQGDYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSR 380
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 880920401 445 NRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELPT 487
Cdd:PRK10604 381 DRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
139-486 |
5.70e-37 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 139.55 E-value: 5.70e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 139 AGLGWRALVVPVYEQDSGQFSGYMTIALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKI 218
Cdd:COG4191 8 LLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 219 AAGDLTKRVTPHPVTTEVGSLALSLNTMLTQVEQSFEARQASEQK---------IKRFVSDASHELRTPLAAISGYCEL- 288
Cdd:COG4191 88 LLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQlvqseklaaLGELAAGIAHEINNPLAAILGNAELl 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 289 --YAMGGVPAERTDEVMGRIASESSRMATLVEDLLTLARLDEGRPldiTDIDLVKLADNAVFDLQALDPTRTVGLTGISG 366
Cdd:COG4191 168 rrRLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDEEER---EPVDLNELIDEALELLRPRLKARGIEVELDLP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 367 RTPPMtliIPGDRDRISQVFTNLIGNIVRYTPEGSP--VEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYradsSR 444
Cdd:COG4191 245 PDLPP---VLGDPGQLEQVLLNLLINAIDAMEEGEGgrITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF----TT 317
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 880920401 445 NRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:COG4191 318 KPVGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLP 359
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
262-486 |
9.04e-37 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 142.97 E-value: 9.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 262 QKIKR----FVSDASHELRTPLAAISGYCELYAMGgvpAERTDEVMGR----IASESSRMATLVEDLLTLARLDEGR-PL 332
Cdd:NF033092 366 EKIEQerreFVANVSHELRTPLTTMRSYLEALADG---AWKDPELAPRflgvTQNETERMIRLVNDLLQLSRMDSKDyKL 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 333 DITDIDLVKLADNAV--FDLQaldpTRTVGLTgISGRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRS 410
Cdd:NF033092 443 NKEWVNFNEFFNYIIdrFEMI----LKNKNIT-FKREFPKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLET 517
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 880920401 411 SDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:NF033092 518 HNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLP 593
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
186-486 |
7.01e-32 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 125.11 E-value: 7.01e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 186 GSIIVLIggwTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVTPHPV-TTEVGSLALSLNTMLTQVEQSFEARQASEQKI 264
Cdd:NF012226 69 GSVISLI---IGMKLAQRFIVPINFLADAAKKISQGDLSARAEDSQIhSAEISELMHNFNDMAQKLESSVKNAQVWNAAI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 265 krfvsdaSHELRTPLAAISGycELYA-MGGV--PaertDEVMGR-IASESSRMATLVEDLLTLArLDEGRPL--DITDID 338
Cdd:NF012226 146 -------AHELRTPITILQG--RLQGiLDGVfeP----DPALFKsLLNQVEGLSHLVEDLRTLS-LVENQQLrlNYESVD 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 339 LVKLADNAVFDLQalDPTRTVGLTGISGRTPPmtlIIPGDRDRISQVFTNLIGNIVRYTPEGSpVEIALGRSSDTAIVEL 418
Cdd:NF012226 212 LKDSIEKVLKMFE--DRLEQAQLTIVLNLTAT---PVFCDRRRIEQVLIALIDNAIRYANAGK-LKISSSVIQDDWILQI 285
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 880920401 419 RDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLtVRIELP 486
Cdd:NF012226 286 EDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQGNSV-FTIKLP 352
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
382-485 |
8.02e-32 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 117.70 E-value: 8.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSrnRKSGGSGLGLAIVSGI 461
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKS--REGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 880920401 462 LAAHRGNASLSKTKGGGLTVRIEL 485
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
377-486 |
9.26e-32 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 117.75 E-value: 9.26e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 377 GDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADsSRNRKSGGSGLGLA 456
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 880920401 457 IVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
201-488 |
1.44e-31 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 124.31 E-value: 1.44e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 201 VRRALLPLRSIESTAGKIAAGDLTkrvtPHPV---TTEVGSLALSLNTMLTQVEQSFearqaseQKIKRFVSDASHELRT 277
Cdd:PRK10755 82 VRWITRPLAELQKELEARTADNLT----PIAIhssTLEIEAVTSALNQLVSRLTSTL-------DQERLFTADVAHELRT 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 278 PLAAISGYCELYAMGGVPaertdEVMGRIASESSRMATlVEDLLTLARLdeGRPLDITDIDLVKLADNAVFDLQ----AL 353
Cdd:PRK10755 151 PLAGIRLHLELLEKQHHI-----DVAPLIARLDQMMHT-VEQLLQLARA--GQSFSSGHYQTVKLLEDVILPSQdelsEM 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 354 DPTRTVGLTGISgrtPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRV 433
Cdd:PRK10755 223 LEQRQQTLLLPE---SAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGEL 299
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 880920401 434 FERFYRADSsrnrKSGGSGLGLAIVSGILAAHRGNASLS-KTKGGGLTVRIELPTT 488
Cdd:PRK10755 300 SKAFVRMDS----RYGGIGLGLSIVSRITQLHHGQFFLQnRQERSGTRAWVWLPKA 351
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
378-486 |
6.01e-31 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 115.64 E-value: 6.01e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 378 DRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAI 457
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 880920401 458 VSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
199-483 |
5.13e-30 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 121.68 E-value: 5.13e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 199 VLVRRALLPLRSIESTAGKIAAGDLTKRVTPHpVTTEVGSLALSLNtmltqveQSFEARQASEQKIKRFVSDASHELRTP 278
Cdd:PRK10337 180 VLLGRELAPLKKLALALRMRDPDSETPLNATG-VPSEVRPLVEALN-------QLFARTHAMMVRERRFTSDAAHELRSP 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 279 LAAISGYCELYAMGGVPAERTDEVMGRIASESSRMATLVEDLLTLARLD-EGRPLDITDIDLVKLADNAVFDLqaLDPTR 357
Cdd:PRK10337 252 LAALKVQTEVAQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDsLDNLQDVAEIPLEDLLQSAVMDI--YHTAQ 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 358 TVGLTgISGRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSdtaiVELRDHGPGIDETDRGRVFERF 437
Cdd:PRK10337 330 QAGID-VRLTLNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN----FTVRDNGPGVTPEALARIGERF 404
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 880920401 438 YRADSsrnRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRI 483
Cdd:PRK10337 405 YRPPG---QEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKV 447
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
273-486 |
1.10e-29 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 119.18 E-value: 1.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 273 HELRTPLAAISGYCELYAMGgVPAERTDEVMGRIASESSRMATLVEDLLTLARldeGRPLDITDIDLVKLADNaVFDLQA 352
Cdd:COG3852 144 HEIRNPLTGIRGAAQLLERE-LPDDELREYTQLIIEEADRLNNLVDRLLSFSR---PRPPEREPVNLHEVLER-VLELLR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 353 LDPTRTVGLT-GISGRTPPmtliIPGDRDRISQVFTNLIGNIVRYTPEG----------SPVEIALGRSSDTAIVELRDH 421
Cdd:COG3852 219 AEAPKNIRIVrDYDPSLPE----VLGDPDQLIQVLLNLVRNAAEAMPEGgtitirtrveRQVTLGGLRPRLYVRIEVIDN 294
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 880920401 422 GPGIDETDRGRVFERFYradSSrnrKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:COG3852 295 GPGIPEEILDRIFEPFF---TT---KEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
248-486 |
2.30e-29 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 119.73 E-value: 2.30e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 248 TQVEQSFEARqaseqkiKRFVSDASHELRTPLAAISGYCELY---AMGGVPAERTDEVMgriASESSRMATLVEDLLTLA 324
Cdd:PRK11006 195 TQMHQLEGAR-------RNFFANVSHELRTPLTVLQGYLEMMqdqPLEGALREKALHTM---REQTQRMEGLVKQLLTLS 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 325 RLdEGRPlditDIDLvkladNAVFDLQA-LDPTRTVGLTgISGRTPPMT------LIIPGDRDRISQVFTNLIGNIVRYT 397
Cdd:PRK11006 265 KI-EAAP----TIDL-----NEKVDVPMmLRVLEREAQT-LSQGKHTITfevdnsLKVFGNEDQLRSAISNLVYNAVNHT 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 398 PEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGG 477
Cdd:PRK11006 334 PEGTHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGK 413
|
....*....
gi 880920401 478 GLTVRIELP 486
Cdd:PRK11006 414 GTRFSFVLP 422
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
207-486 |
7.73e-29 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 118.50 E-value: 7.73e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 207 PLRSIESTAGKIAAGDLTkrvtPHPvTTEVGSLAL-----SLNTMLTQVEQSFEARQaseqkikRFVSDASHELRTPLAA 281
Cdd:PRK09470 193 PARKLKNAADEVAQGNLR----QHP-ELETGPQEFrqagaSFNQMVTALERMMTSQQ-------RLLSDISHELRTPLTR 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 282 ISgycelyaMGGVPAER---TDEVMGRIASESSRMATLVEDLLTLARLD-----EGRPLDITDI--DLVklaDNAVFDLQ 351
Cdd:PRK09470 261 LQ-------LATALLRRrqgESKELERIETEAQRLDSMINDLLVLSRNQqknhlERETFKANSLwsEVL---EDAKFEAE 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 352 ALDPTRTVgltgisgRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTpeGSPVEIALGRSSDTAIVELRDHGPGIDETDRG 431
Cdd:PRK09470 331 QMGKSLTV-------SAPPGPWPINGNPNALASALENIVRNALRYS--HTKIEVAFSVDKDGLTITVDDDGPGVPEEERE 401
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 880920401 432 RVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:PRK09470 402 QIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-485 |
1.96e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 108.65 E-value: 1.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 377 GDRDRISQVFTNLIGNIVRYTPEGSPVEIALgRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSsrnRKSGGSGLGLA 456
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLS 84
|
90 100
....*....|....*....|....*....
gi 880920401 457 IVSGILAAHRGNASLSKTKGGGLTVRIEL 485
Cdd:cd16940 85 IVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-487 |
1.43e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 103.17 E-value: 1.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGNIVRYTPEgsPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGI 461
Cdd:cd16949 1 LARALENVLRNALRYSPS--KILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 880920401 462 LAAHRGNASLSKTKGGGLTVRIELPT 487
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
377-486 |
2.13e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 102.83 E-value: 2.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 377 GDRDRISQVFTNLIGNIVRYTPEGSPVEIALgRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSsrnRKSGGSGLGLA 456
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTL-SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 880920401 457 IVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
255-486 |
3.29e-24 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 106.79 E-value: 3.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 255 EARQASEQKiKRFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVMGRIASESSRMATLvEDLLTLARLDEGRpLDI 334
Cdd:TIGR02956 456 EAEEANRAK-SAFLATMSHEIRTPLNGILGTLELLGDTGLTSQQQQYLQVINRSGESLLDIL-NDILDYSKIEAGH-LSI 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 335 --TDIDLVKLADNAVFDLQAldPTRTVGLTGISGRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSpVEIALGRSSD 412
Cdd:TIGR02956 533 spRPFDLNALLDDVHHLMVS--RAQLKGIQLRLNIPEQLPNWWQGDGPRIRQVLINLVGNAIKFTDRGS-VVLRVSLNDD 609
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 880920401 413 TAI-VELRDHGPGIDETDRGRVFERFYRADSsrNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:TIGR02956 610 SSLlFEVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLP 682
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
235-486 |
2.67e-23 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 103.57 E-value: 2.67e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 235 EVGSLALSLNTMLTQVEQSF---------------EARQASEQKIKR---FVSDASHELRTPLAAISGYCELYAMGGVPA 296
Cdd:PRK15347 351 ELGSIAKAYNQLLDTLNEQYdtlenkvaertqalaEAKQRAEQANKRkseHLTTISHEIRTPLNGVLGALELLQNTPLTA 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 297 ERTDevMGRIASESSR-MATLVEDLLTLARLDEGR-PLDITDIDLVKLADNAVFDLQALDPTRTVGLTGISGRTPPMTLI 374
Cdd:PRK15347 431 EQMD--LADTARQCTLsLLAIINNLLDFSRIESGQmTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYLH 508
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 375 IpgDRDRISQVFTNLIGNIVRYTPEGSpVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSrnrkSGGSGLG 454
Cdd:PRK15347 509 L--DSLRLRQILVNLLGNAVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLG 581
|
250 260 270
....*....|....*....|....*....|..
gi 880920401 455 LAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:PRK15347 582 LTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
385-486 |
5.14e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 93.22 E-value: 5.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 385 VFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNrkSGGSGLGLAIVSGILAA 464
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAIIEL 81
|
90 100
....*....|....*....|..
gi 880920401 465 HRGNASLSkTKGGGLTVRIELP 486
Cdd:cd16923 82 HGGSASAE-YDDNHDLFKVRLP 102
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
188-488 |
8.54e-23 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 100.37 E-value: 8.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 188 IIVLIGGWT-GRVLVRrallPLRSIESTAGKIAAGDLtkrvtPHPV----TTEVGSLALSLNTMltqveqsfearqasEQ 262
Cdd:PRK09467 164 LLSVAGGWLfIRIQNR----PLVALEHAALQVGKGEI-----PPPLreygASEVRSVTRAFNQM--------------AA 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 263 KIKRFVSD-------ASHELRTPLAAIsgycelyamggvpaertdevmgRIASEssrMatLVEDLLTLArldEGRPLDIT 335
Cdd:PRK09467 221 GIKQLEDDrtllmagVSHDLRTPLTRI----------------------RLATE---M--MSEEDGYLA---ESINKDIE 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 336 DIdlvkladNAVFDlQALDPTRT--------VGLTGI--------SGRT-------PPMTLIIPGDRDRISQVFTNLIGN 392
Cdd:PRK09467 271 EC-------NAIIE-QFIDYLRTgqempmemADLNALlgeviaaeSGYEreietalQPGPIEVPMNPIAIKRALANLVVN 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 393 IVRYTpeGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNrkSGGSGLGLAIVSGILAAHRGNASLS 472
Cdd:PRK09467 343 AARYG--NGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIVDQHNGKVELG 418
|
330
....*....|....*.
gi 880920401 473 KTKGGGLTVRIELPTT 488
Cdd:PRK09467 419 NSEEGGLSARAWLPLT 434
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
272-487 |
1.61e-22 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 100.05 E-value: 1.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 272 SHELRTPLAAISGYCELYAMGGVPAERT-DEVMgriASESSRMATLVEDLLTLARLDEGR--PLDITDI--DLVKLadna 346
Cdd:COG5809 278 AHEIRNPLTSLKGFIQLLKDTIDEEQKTyLDIM---LSELDRIESIISEFLVLAKPQAIKyePKDLNTLieEVIPL---- 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 347 vFDLQALdptrtvgLTGI------SGRTPPmtliIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIV-ELR 419
Cdd:COG5809 351 -LQPQAL-------LKNVqielelEDDIPD----ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVViSVT 418
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 880920401 420 DHGPGIDETDRGRVFERFYradssrNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELPT 487
Cdd:COG5809 419 DEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPI 480
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
266-487 |
1.01e-21 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 98.50 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 266 RFVSDASHELRTPLAAISGYCELYAMGGVPAErTDEVMGRIASESSRMATLVEDLLTLARldeGRPLDITDIDLVKLADN 345
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPP-SQEYLSVVLREVDRLNKVIDQLLEFSR---PRESQWQPVSLNALVEE 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 346 AVFDLQALDPTRTVGL-TGISGRTPPmtliIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAI-VELRDHGP 423
Cdd:PRK11360 468 VLQLFQTAGVQARVDFeTELDNELPP----IWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVaVSIEDNGC 543
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 880920401 424 GIDETDRGRVFERFYradssrNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELPT 487
Cdd:PRK11360 544 GIDPELLKKIFDPFF------TTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-486 |
4.04e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 88.26 E-value: 4.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGNIVRYTpeGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGI 461
Cdd:cd16939 1 MARALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*
gi 880920401 462 LAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16939 79 ALWHGGHVECDDSELGGACFRLTWP 103
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
378-486 |
3.54e-20 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 85.62 E-value: 3.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 378 DRDRISQVFTNLIGNIVRYTPEGSPVEIALGRS-SDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLA 456
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFrLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 880920401 457 IVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-486 |
3.71e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 85.19 E-value: 3.71e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGNIVRYTpeGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNrkSGGSGLGLAIVSGI 461
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRI 76
|
90 100
....*....|....*....|....*
gi 880920401 462 LAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16950 77 SDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
384-486 |
4.45e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 85.24 E-value: 4.45e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 384 QVFTNLIGNIVRYTPEGSpVEIALGRSSDTA-----IVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIV 458
Cdd:cd16922 3 QILLNLLGNAIKFTEEGE-VTLRVSLEEEEEdgvqlRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAIS 81
|
90 100
....*....|....*....|....*...
gi 880920401 459 SGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16922 82 KKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
386-486 |
8.54e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 84.56 E-value: 8.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 386 FTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAH 465
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|.
gi 880920401 466 RGNASLSKTKGGGLTVRIELP 486
Cdd:cd16952 85 DARLLIASELGKGSRFTCLFP 105
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
266-486 |
1.16e-19 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 92.49 E-value: 1.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 266 RFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVMGRIASESSRMATLVEDLLTLARLDEGR-PLDITDIDLVKLAD 344
Cdd:PRK09959 714 QFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNyQLQPQWVDIPTLVQ 793
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 345 NAVFDLQALDPTRTVGLTGISgrTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGS-PVEIALGRSSDT-AIVELR--D 420
Cdd:PRK09959 794 NTCHSFGAIAASKSIALSCSS--TFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLGHIDDNhAVIKMTimD 871
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 880920401 421 HGPGIDETDRGRVFERFyrADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:PRK09959 872 SGSGLSQEEQQQLFKRY--SQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIP 935
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
273-486 |
3.58e-19 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 90.18 E-value: 3.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 273 HELRTPLAAISGYCELYAMGgvpAERTDEVMGRIASESSRMATLVEDLLTLARLDEG--RPLDITDI--DLVKLA----- 343
Cdd:COG5805 296 HEIRNPLTSIKGFLQLLQPG---IEDKEEYFDIMLSELDRIESIISEFLALAKPQAVnkEKENINELiqDVVTLLeteai 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 344 -DNAVFDLQALDPTrtvgltgisgrtppmtLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHG 422
Cdd:COG5805 373 lHNIQIRLELLDED----------------PFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEG 436
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 880920401 423 PGIDETDRGRVFERFYradssrNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:COG5805 437 IGIPEERLKKLGEPFF------TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
235-486 |
1.14e-18 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 89.03 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 235 EVGSLALSLNTMLTQVEQSfearqasEQKIKRFVSDASHELRTPLAAISGYCELYAMGGVPAERTdEVMGRIASESSRMA 314
Cdd:TIGR03785 463 EIGDLSRSFAQMVARLRQY-------THYLENMSSRLSHELRTPVAVVRSSLENLELQALEQEKQ-KYLERAREGTERLS 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 315 TLVEDLLTLARLDEG-RPLDITDIDLVKLADNAVFDLQALDPTRTVGLtgiSGRTPPMTLIIPGdrDRISQVFTNLIGNI 393
Cdd:TIGR03785 535 MILNNMSEATRLEQAiQSAEVEDFDLSEVLSGCMQGYQMTYPPQRFEL---NIPETPLVMRGSP--ELIAQMLDKLVDNA 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 394 VRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSK 473
Cdd:TIGR03785 610 REFSPEDGLIEVGLSQNKSHALLTVSNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAEN 689
|
250
....*....|....
gi 880920401 474 T-KGGGLTVRIELP 486
Cdd:TIGR03785 690 RqQNDGVVFRISLP 703
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
205-486 |
1.53e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 88.94 E-value: 1.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 205 LLPLRSIESTAGKIA--AGDLTKRVTPHP---VTTEVGSLALSLNTM-LTQVEQSfeARQASEQKIKR--FVSDASHELR 276
Cdd:PRK10490 599 ILPLKSAQKTYGLLAvePGNLRQLMIPEQqrlLETFTLLIANALERLtLTASEEQ--ARLASEREQLRnaLLAALSHDLR 676
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 277 TPLAAISGYCE-----LYAMGGVPAERTDEVMGRIASeSSRmatLVEDLLTLARLD-EGRPLDITDIDLVKLADNAvfdL 350
Cdd:PRK10490 677 TPLTVLFGQAEiltldLASEGSPHARQASEIRQQVLN-TTR---LVNNLLDMARIQsGGFNLRKEWLTLEEVVGSA---L 749
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 351 QALDPtrtvGLTG--ISGRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDET 428
Cdd:PRK10490 750 QMLEP----GLSGhpINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPG 825
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 429 DRGRVFERFYRAdssrNRKSG--GSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:PRK10490 826 QEQLIFDKFARG----NKESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-486 |
2.32e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 80.45 E-value: 2.32e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGNIVRYTPEGSP--VEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSsrNRKSGGSGLGLAIVS 459
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 880920401 460 GILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
273-467 |
2.21e-17 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 83.85 E-value: 2.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 273 HELRTPLAAISGYCELYAMG--GVPAERTDEVMGRIASESSR----MATLVEDLLTLAR-LDEGRPLDITDIDLVKLADN 345
Cdd:PRK09303 160 HDLRTPLTAASLALETLELGqiDEDTELKPALIEQLQDQARRqleeIERLITDLLEVGRtRWEALRFNPQKLDLGSLCQE 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 346 AVFDLQALDPTRTVGL-TGISGRTPPmtliIPGDRDRISQVFTNLIGNIVRYTPEGSPVEI-ALGRSSDTAIVELRDHGP 423
Cdd:PRK09303 240 VILELEKRWLAKSLEIqTDIPSDLPS----VYADQERIRQVLLNLLDNAIKYTPEGGTITLsMLHRTTQKVQVSICDTGP 315
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 880920401 424 GIDETDRGRVFERFYRADssRNRKSGGSGLGLAIVSGILAAHRG 467
Cdd:PRK09303 316 GIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
255-486 |
3.61e-17 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 84.57 E-value: 3.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 255 EARQASEQKiKRFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVMGRIASESSRMATLvEDLLTLARLDEGRpldi 334
Cdd:PRK11466 436 EAEKASQAK-SAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTIL-NDILDYSAIEAGG---- 509
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 335 tdiDLVKLADNAVFDLQALDPTRTVGLTGISGRtpPMTLI----------IPGDRDRISQVFTNLIGNIVRYTPEGSpVE 404
Cdd:PRK11466 510 ---KNVSVSDEPFEPRPLLESTLQLMSGRVKGR--PIRLAtdiaddlptaLMGDPRRIRQVITNLLSNALRFTDEGS-IV 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 405 IALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRnrksGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIE 484
Cdd:PRK11466 584 LRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLR 659
|
..
gi 880920401 485 LP 486
Cdd:PRK11466 660 LP 661
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
378-484 |
8.22e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 75.96 E-value: 8.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 378 DRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKsGGSGLGLAI 457
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYI 79
|
90 100
....*....|....*....|....*..
gi 880920401 458 VSGILAAHRGNASLSKTKGGGLTVRIE 484
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
261-325 |
1.51e-16 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 73.79 E-value: 1.51e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 880920401 261 EQKIKRFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVMGRIASESSRMATLVEDLLTLAR 325
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
239-486 |
3.83e-16 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 80.60 E-value: 3.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 239 LALSLNTMLTQV--EQSFEARQASEQKIKR---------FVSDASHELRTPLAAISGYCELYAM---GGVPAERTDEVMg 304
Cdd:PRK10364 201 ATVLLASLLAFFwyRRYLRSRQLLQDEMKRkeklvalghLAAGVAHEIRNPLSSIKGLAKYFAErapAGGEAHQLAQVM- 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 305 riASESSRMATLVEDLLTLARLDEGRPLDITDIDLVkladNAVFDLQALDPTRTvgltGISGR-TPPMTL-IIPGDRDRI 382
Cdd:PRK10364 280 --AKEADRLNRVVSELLELVKPTHLALQAVDLNDLI----NHSLQLVSQDANSR----EIQLRfTANDTLpEIQADPDRL 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 383 SQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRAdssrnrKSGGSGLGLAIVSGIL 462
Cdd:PRK10364 350 TQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTT------KAEGTGLGLAVVHNIV 423
|
250 260
....*....|....*....|....
gi 880920401 463 AAHRGNASLSKTKGGGLTVRIELP 486
Cdd:PRK10364 424 EQHGGTIQVASQEGKGATFTLWLP 447
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
266-329 |
8.20e-16 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 71.86 E-value: 8.20e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 880920401 266 RFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVmGRIASESSRMATLVEDLLTLARLDEG 329
Cdd:pfam00512 4 EFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYL-ETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
226-486 |
9.08e-16 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 80.11 E-value: 9.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 226 RVTPH--PVTTEVGSLALSLNTM-----LTQVEQSFEARQASEQKIKR------FVSDASHELRTPLAAISGYCELYAMG 292
Cdd:PRK13837 399 RQRYGlrPPAGELQLLELALDCLahaieRRRLETERDALERRLEHARRleavgtLASGIAHNFNNILGAILGYAEMALNK 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 293 GVPAERTDEVMGRIASESSRMATLVEDLLTLARLDEGRpldITDIDLVKLADNAVFDLQALDPtRTVGLtgiSGRTPPMT 372
Cdd:PRK13837 479 LARHSRAARYIDEIISAGARARLIIDQILAFGRKGERN---TKPFDLSELVTEIAPLLRVSLP-PGVEL---DFDQDQEP 551
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 373 LIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTA-------------IVELR--DHGPGIDETDRGRVFERF 437
Cdd:PRK13837 552 AVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLRApkvlshgvlppgrYVLLRvsDTGAGIDEAVLPHIFEPF 631
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 880920401 438 YRAdssrnrKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:PRK13837 632 FTT------RAGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLP 674
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
265-329 |
1.98e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 70.67 E-value: 1.98e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 880920401 265 KRFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVmGRIASESSRMATLVEDLLTLARLDEG 329
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYL-ETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
379-486 |
3.62e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 71.30 E-value: 3.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 379 RDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYradSSRNRKSgGSGLGLAIV 458
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF---TTKPVGE-GTGLGLSLS 76
|
90 100
....*....|....*....|....*...
gi 880920401 459 SGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
377-472 |
4.28e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 71.78 E-value: 4.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 377 GDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLA 456
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLT 95
|
90
....*....|....*.
gi 880920401 457 IVSGILAAHRGNASLS 472
Cdd:cd16947 96 ITKRLAESMGGSIYVN 111
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-479 |
5.24e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 70.95 E-value: 5.24e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 384 QVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFY---RADSSrnRKSggSGLGLAIVSG 460
Cdd:cd16945 7 QAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYslpRPHSG--QKS--TGLGLAFVQE 82
|
90
....*....|....*....
gi 880920401 461 ILAAHRGNASLSKTKGGGL 479
Cdd:cd16945 83 VAQLHGGRITLRNRPDGVL 101
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-486 |
5.46e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 70.89 E-value: 5.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGN----IVRYTPEGSPVEIALGRSSDTA-IVELRDHGPGIDETDRGRVFERFYRAdssrnrKSGGSGLGLA 456
Cdd:cd16920 1 IQQVLINLVRNgieaMSEGGCERRELTIRTSPADDRAvTISVKDTGPGIAEEVAGQLFDPFYTT------KSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 880920401 457 IVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
152-457 |
7.74e-15 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 77.20 E-value: 7.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 152 EQDSGQFSGYMTIALPLSDM---QHtlRTtasyfAVAGSIIVLIG-------GWtgRvLVRRALLPLRSIESTAGKIAAG 221
Cdd:PRK11107 150 AKNSQNMLGYIAIELDLKSVrlqQY--RE-----IFIAFLMLLLGiglallfAF--R-LMRDVTGPIRNMVNTVDRIRRG 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 222 DLTKRVTPHpVTTEVGSLALSLNTM-------------------------LTQVE-QSFE-------ARQASeqKIK-RF 267
Cdd:PRK11107 220 QLDSRVEGN-MLGELDMLKNGINAMamslsayheemqqnidqatsdlretLEQMEiQNVEldlakkrAQEAA--RIKsEF 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 268 VSDASHELRTPLAAISGYcelyamggvpaerTDEVMGRIASESS--------RMATlveDLLTLarldegrpldITDI-D 338
Cdd:PRK11107 297 LANMSHELRTPLNGVIGF-------------TRQTLKTPLTPTQrdylqtieRSAN---NLLAI----------INDIlD 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 339 LVKLA------DNAVFDLQA-LDPTRTV--------GLTgisgrtppMTLIIP--------GDRDRISQVFTNLIGNIVR 395
Cdd:PRK11107 351 FSKLEagklvlENIPFSLREtLDEVVTLlahsahekGLE--------LTLNIDpdvpdnviGDPLRLQQIITNLVGNAIK 422
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 880920401 396 YTPEGS-PVEIALGRSSDTAI---VELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAI 457
Cdd:PRK11107 423 FTESGNiDILVELRALSNTKVqleVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVI 488
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
259-486 |
6.71e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 71.13 E-value: 6.71e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 259 ASEQKIKrFVSDASHELRTPLAAISGyceLYAMGgVPAERTDEVMGRIASESSRMATL---VEDLLTLARLDEGR----- 330
Cdd:PRK11091 279 ASRDKTT-FISTISHELRTPLNGIVG---LSRIL-LDTELTAEQRKYLKTIHVSAITLgniFNDIIDMDKMERRKlqldn 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 331 -PLDITDI--DLVKLADnavfdLQALDPtrtvGLTGISGRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGspvEIAL 407
Cdd:PRK11091 354 qPIDFTDFlaDLENLSG-----LQAEQK----GLRFDLEPLLPLPHKVITDGTRLRQILWNLISNAVKFTQQG---GVTV 421
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 408 GRSSDTAIV---ELRDHGPGIDETDRGRVFERFYRA-DSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRI 483
Cdd:PRK11091 422 RVRYEEGDMltfEVEDSGIGIPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTL 501
|
...
gi 880920401 484 ELP 486
Cdd:PRK11091 502 TIH 504
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-485 |
8.16e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 65.35 E-value: 8.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 373 LIIPGDRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVElrDHGPGIDETDRGRVFERFYRADSSRNrksgGSG 452
Cdd:cd16954 29 LRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVD--DDGPGVPESQRSKIFQRGQRLDEQRP----GQG 102
|
90 100 110
....*....|....*....|....*....|...
gi 880920401 453 LGLAIVSGILAAHRGNASLSKTKGGGLTVRIEL 485
Cdd:cd16954 103 LGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
272-486 |
5.48e-12 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 67.18 E-value: 5.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 272 SHELRTPLAAISGYCELyamggvpaERTDEVMGRIASESSRMATLVEDLLT-----------LARLDEGRPLDITdidlV 340
Cdd:COG3290 197 RHDFRNHLHTISGLLQL--------GEYDEALEYIDEISEELQELIDSLLSrignpvlaallLGKAARARERGID----L 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 341 KLADNAVFDLQALDPTrtvgltgisgrtppmTLIIpgdrdrisqVFTNLIGNIVRYTPEGSP----VEIALGRSSDTAIV 416
Cdd:COG3290 265 TIDIDSDLPDLPLSDT---------------DLVT---------ILGNLLDNAIEAVEKLPEeerrVELSIRDDGDELVI 320
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 417 ELRDHGPGIDETDRGRVFERFYradSSRnrKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:COG3290 321 EVEDSGPGIPEELLEKIFERGF---STK--LGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLP 385
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
161-486 |
3.63e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 65.04 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 161 YMTIALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKrvTPHPVTTEVGSLA 240
Cdd:COG2972 138 TLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR--LEVSGNDEIGILA 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 241 LSLNTMLTQVEQSFEARQASEQKIKRFvsdashELRT------P------LAAISGYCElyaMGGvpAERTDEVMGRIA- 307
Cdd:COG2972 216 RSFNEMVERIKELIEEVYELELEKKEA------ELKAlqaqinPhflfntLNSIRWLAE---LED--PEEAEEMLEALSk 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 308 ------SESSRMATL------VEDLLTL--ARLDEGrpLDItDIDLVKLADNAvfdlqaldptrtvgltgisgRTPPMTL 373
Cdd:COG2972 285 llryslSKGDELVTLeeelelIKSYLEIqkLRFGDR--LEV-EIEIDEELLDL--------------------LIPKLIL 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 374 IIpgdrdrisqvftnLIGNIVRY----TPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFyradssrNRKSG 449
Cdd:COG2972 342 QP-------------LVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGE 401
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 880920401 450 GSGLGLAIVSGILAAHRGNA---SLSKTKGGGLTVRIELP 486
Cdd:COG2972 402 GRGIGLRNVRERLKLYYGEEyglEIESEPGEGTTVTIRIP 441
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
251-485 |
1.07e-10 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 64.22 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 251 EQSFEARQASEQKiKRFVSDASHELRTPLAAISGYCELYAMGGVPAErTDEVMGRIASESSRMATLVEDLLTLARLdEGR 330
Cdd:PRK10841 435 EMAQAAEQASQSK-SMFLATVSHELRTPLYGIIGNLDLLQTKELPKG-VDRLVTAMNNSSSLLLKIISDILDFSKI-ESE 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 331 PLDItdidlvkladnavfdlqalDP----TRTVgLTGISGRTPPM------TL----------IIPGDRDRISQVFTNLI 390
Cdd:PRK10841 512 QLKI-------------------EPrefsPREV-INHITANYLPLvvkkrlGLycfiepdvpvALNGDPMRLQQVISNLL 571
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 391 GNIVRYTPEGSPVeIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNAS 470
Cdd:PRK10841 572 SNAIKFTDTGCIV-LHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDIS 650
|
250
....*....|....*..
gi 880920401 471 LSKTKGGG--LTVRIEL 485
Cdd:PRK10841 651 VDSEPGMGsqFTIRIPL 667
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
388-486 |
5.10e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 56.53 E-value: 5.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 388 NLIGNIV----RYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRksggsGLGLAIVSGILA 463
Cdd:cd16915 7 NLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 880920401 464 AHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-467 |
6.36e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 56.43 E-value: 6.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 384 QVFTNLIGNIVRYTPEGS-PVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGIL 462
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQII 82
|
....*
gi 880920401 463 AAHRG 467
Cdd:cd16953 83 EAHGG 87
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
208-484 |
1.11e-09 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 60.42 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 208 LRSIESTAGKIAAGDLTKRVTPHPVTT-EVGSLALSLNTMLTQVEQSFEarqaseqKIKRFVSDASHELRTPLAAI-SGY 285
Cdd:PRK10815 216 LRPIEALAKQVRELEEGEREQLDPNPPrELTSLVRNLNRLLKNERERYT-------KYRTTLTDLTHSLKTPLAVLqSTL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 286 CELYAMGGVPAERTDEVMgriASESSRMATLVEDLLTLARLDEGRPLDITDIDLVK-LADNAVFDLQALDPTRTVGLT-G 363
Cdd:PRK10815 289 RSLRSGKQMSVEQAEPIM---LEQISRISQQIGYYLHRASMRSEHNLLSRELHSVApLLDNLTSALNKVYQRKGVNITlD 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 364 ISgrtPPMTLIipGDRDRISQVFTNLIGNIVRYTPEGspVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSS 443
Cdd:PRK10815 366 IS---PEITFV--GEKNDFMEVMGNVLDNACKYCLEF--VEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTL 438
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 880920401 444 RNrksgGSGLGLAIVSGILAAHRGNASLSKTKGGGltVRIE 484
Cdd:PRK10815 439 RP----GQGLGLSVAREITEQYEGKISAGDSPLGG--ARME 473
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
378-486 |
3.00e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 54.47 E-value: 3.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 378 DRDRISQVFTNLIGNIVRyTPEGSP-------VEIALGRSSDTAIVeLRDHGPGIDETDRGRVFERfYRADSSRnrksgG 450
Cdd:cd16944 1 DTTQISQVLTNILKNAAE-AIEGRPsdvgevrIRVEADQDGRIVLI-VCDNGKGFPREMRHRATEP-YVTTRPK-----G 72
|
90 100 110
....*....|....*....|....*....|....*.
gi 880920401 451 SGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16944 73 TGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
164-488 |
3.43e-09 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 58.74 E-value: 3.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 164 IALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVTPHPvTTEVGSLALSL 243
Cdd:COG3850 102 LLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSG-RDELGTLARAF 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 244 NTMLTQVEQSFEARQASEQKIKRFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVMGRIASESSRMATLVEDLLTL 323
Cdd:COG3850 181 NRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILA 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 324 ARLDEGRPLDITDIDLVKLADNAVFDLQALDPTRTVGLTGISGRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEGSPV 403
Cdd:COG3850 261 GLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAAL 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 404 EIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRI 483
Cdd:COG3850 341 LELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVDVEGGVAGEGGLVVLI 420
|
....*
gi 880920401 484 ELPTT 488
Cdd:COG3850 421 VSIIA 425
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-485 |
3.78e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 54.00 E-value: 3.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGNI---VRYTPEGSpVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYradssRNRKSG-GSGLGLAI 457
Cdd:cd16976 1 IQQVLMNLLQNAldaMGKVENPR-IRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSI 74
|
90 100
....*....|....*....|....*...
gi 880920401 458 VSGILAAHRGNASLSKTKGGGLTVRIEL 485
Cdd:cd16976 75 SYGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
378-486 |
1.07e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 53.06 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 378 DRDRISQVFTNLIGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRN-RKSggSGLGLA 456
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNfQES--TGMGLY 79
|
90 100 110
....*....|....*....|....*....|
gi 880920401 457 IVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16948 80 LVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HAMP |
pfam00672 |
HAMP domain; |
199-252 |
2.41e-08 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 50.32 E-value: 2.41e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 880920401 199 VLVRRALLPLRSIESTAGKIAAGDLTKRVTPHPvTTEVGSLALSLNTMLTQVEQ 252
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSG-RDEIGELARAFNQMAERLRE 53
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
182-486 |
4.07e-08 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 55.85 E-value: 4.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 182 FAVAGSIIVLIGgwtgRVLVRRALLP-LRSIESTAGKIAAGDLTkrvtpHPVTT----EVGSLALSL-------NTMLTQ 249
Cdd:COG4192 332 ALLSLLLAVLIN----YFYVRRRLVKrLNALSDAMAAIAAGDLD-----VPIPVdgndEIGRIARLLrvfrdqaIEKTQE 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 250 VEQSFEARQASEQKIKRFVSD----------------ASHELRTPLAAISGYceLY----AMGGVPAERTDEVMGRIASE 309
Cdd:COG4192 403 LETEIEERKRIEKNLRQTQDEliqaakmavvgqtmtsLAHELNQPLNAMSMY--LFsakkALEQENYAQLPTSLDKIEGL 480
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 310 SSRMATLVEDLLTLARLDEGrplDITDIDLVKLADNAVFDLQALDPTRTVGLTgisgrtPPMTLIIPGDRDRISQVFTNL 389
Cdd:COG4192 481 IERMDKIIKSLRQFSRKSDT---PLQPVDLRQVIEQAWELVESRAKPQQITLH------IPDDLMVQGDQVLLEQVLVNL 551
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 390 IGNIVRYTPEGSPVEIALGRSSDTAIVELRDHGPGIDETDrgRVFERFYradssrNRKSGGSGLGLAIVSGILAAHRGNA 469
Cdd:COG4192 552 LVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVD--KLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDL 623
|
330
....*....|....*..
gi 880920401 470 SLSKTKGGGLTVRIELP 486
Cdd:COG4192 624 YLASTLERGAMVILEFN 640
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
202-255 |
4.15e-08 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 49.55 E-value: 4.15e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 880920401 202 RRALLPLRSIESTAGKIAAGDLTKRVTPHPvTTEVGSLALSLNTMLTQVEQSFE 255
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDG-RDEIGELARAFNEMADRLEETIA 53
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
1-484 |
1.19e-07 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 54.35 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 1 MRPGLAQRIEAWWDSKPLSSQLVTLITSLLAVGLSLSGTVMIGLLQRHLTSQIDDQLIATAHTLQISASTATFSADGQGG 80
Cdd:COG2770 33 LRLLLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 81 IPTLYYIHIRNTDGTDRYFYSEDTLKVSGKPDLPDLVDTSSAPISSFRTLPITVSSSKAGLGWRALVVPVYEQDSGQFSG 160
Cdd:COG2770 113 LLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 161 YMTIALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRRALLPLRSIESTAGKIAAGDLTKRVTPHPvTTEVGSLA 240
Cdd:COG2770 193 LLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSR-KDEIGELA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 241 LSLNTMLTQVEQSFEARQASEQKIKRFVSDASHELRTPLAAISGYCELYAMGGVPAERTDEVMGRIASESSRMATLVEDL 320
Cdd:COG2770 272 RAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLL 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 321 LTLARLDEGRPLDITDIDLVKLADNAVFDLQALDPTRTVGLTGISGRTPPMTLIIPGDRDRISQVFTNLIGNIVRYTPEG 400
Cdd:COG2770 352 LALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAA 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 401 SPVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYRADSSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLT 480
Cdd:COG2770 432 EAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLL 511
|
....
gi 880920401 481 VRIE 484
Cdd:COG2770 512 LEGL 515
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
5-320 |
4.78e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 52.33 E-value: 4.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 5 LAQRIEAWWDSKPLSSQLVTLITSLLAVGLSLSGTVMIGLLQRHLTSQIDDQLIATAHTLQISASTATFSADGQGGIPTL 84
Cdd:COG0840 11 LLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLALLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 85 YYIHIRNTDGTDRYFYSEDTLKVSGKPDLPDLVDTSSAPISSFRTLPITVSSSKAGLGWRALVVPVYEQDSGQFSGYMTI 164
Cdd:COG0840 91 LLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 165 ALPLSDMQHTLRTTASYFAVAGSIIVLIGGWTGRVLVRrallPLRSIESTAGKIAAGDLTKRVtphPVTT--EVGSLALS 242
Cdd:COG0840 171 ALALAAAALALALLAAALLALVALAIILALLLSRSITR----PLRELLEVLERIAEGDLTVRI---DVDSkdEIGQLADA 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 880920401 243 LNTMLTQVEQSF-EARQASEQkikrfVSDASHElrtpLAAISGycELyamggvpAERTDEVmgriASESSRMATLVEDL 320
Cdd:COG0840 244 FNRMIENLRELVgQVRESAEQ-----VASASEE----LAASAE--EL-------AAGAEEQ----AASLEETAAAMEEL 300
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
207-249 |
6.22e-07 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 45.90 E-value: 6.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 880920401 207 PLRSIESTAGKIAAGDLTKRVtphPVTT--EVGSLALSLNTMLTQ 249
Cdd:cd06225 3 PLRRLTEAARRIAEGDLDVRV---PVRSkdEIGELARAFNQMAER 44
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
382-467 |
8.78e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 44.70 E-value: 8.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 382 ISQVFTNLIGNIVRYTPEGS-----------PVEIALGRSSDTAIVELRDHGPGIDETDRGRVFERFYradSSRnrkSGG 450
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgeiilrtrtqrQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV---SGR---ENG 74
|
90
....*....|....*..
gi 880920401 451 SGLGLAIVSGILAAHRG 467
Cdd:cd16918 75 TGLGLAIAQNIVSQHGG 91
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
378-458 |
7.82e-05 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 42.21 E-value: 7.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 378 DRDRISQVFTNLIGNIVRYTPEGSP---VEIALGRSSDTAIVELRDHGPGIDETDRGRVFERfyradssrnrkSGGSGLG 454
Cdd:COG2172 31 DADDLVLAVSEAVTNAVRHAYGGDPdgpVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYST-----------LAEGGRG 99
|
....
gi 880920401 455 LAIV 458
Cdd:COG2172 100 LFLI 103
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
409-486 |
1.42e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 41.21 E-value: 1.42e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 880920401 409 RSSDTAIVELRDHGPGIDETDRGRVFERFYradsSRNRKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:cd16919 43 IPGNYVCLEVSDTGSGMPAEVLRRAFEPFF----TTKEVGKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
296-486 |
1.85e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 43.07 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 296 AERTDEVMGRIASESSRMATLVEDLLTLAR--LDEGRPLDITDIDLVKLADNAVFDLQALdptrtvglTGIsgrtpPMTL 373
Cdd:COG4585 80 RRLLDADPEAAREELEEIRELAREALAELRrlVRGLRPPALDDLGLAAALEELAERLLRA--------AGI-----RVEL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 374 IIPGDRDRISQ--------VFTNLIGNIVRYTPeGSPVEIALGRSSDTAIVELRDHGPGIDETdrgrvferfyradssrn 445
Cdd:COG4585 147 DVDGDPDRLPPevelalyrIVQEALTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPE----------------- 208
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 880920401 446 rKSGGSGLGLAIVSGILAAHRGNASLSKTKGGGLTVRIELP 486
Cdd:COG4585 209 -AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLP 248
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
389-485 |
2.44e-04 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 39.94 E-value: 2.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 389 LIGNIVRYT---PEGSPVEIALGRSSDTAIVELRDHGPGIDetdrgrvferfYRADSSRNRKSGGSGLGLAIVSGiLAAH 465
Cdd:cd16936 8 AVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFD-----------PLRPADPDAGLREGGRGLALIRA-LMDE 75
|
90 100
....*....|....*....|
gi 880920401 466 RGnaslSKTKGGGLTVRIEL 485
Cdd:cd16936 76 VG----YRRTPGGKTVWLEL 91
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
378-459 |
1.33e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 41.36 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 378 DRDRISQVFTNLIGNIVR---YTPEGSP-VEIALGRSSDTAIVELRDHGPGIDETDRGRVFErfyRADSSRNRKSGGSGL 453
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEaslRSDEGNKiVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE---QGVSTRADEPGEHGI 505
|
....*.
gi 880920401 454 GLAIVS 459
Cdd:PRK15053 506 GLYLIA 511
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
300-486 |
2.12e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 40.66 E-value: 2.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 300 DEVMGRIASessrMAtLVEDLLTlarldegRPLDITDIDLVKLADNAVFDLQALDPTRTVGLTgISGrtPPMTLiipgDR 379
Cdd:COG3920 334 EESQNRIQA----LA-LVHELLY-------QSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIE-LDG--PDVEL----PA 394
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 380 DR---ISQVFTNLIGNIVRY----TPEGSpVEIALGRSSDTAIVELRDHGPGIDETdrgrvferfyradssrNRKSGGSG 452
Cdd:COG3920 395 DAavpLGLILNELVTNALKHaflsGEGGR-IRVSWRREDGRLRLTVSDNGVGLPED----------------VDPPARKG 457
|
170 180 190
....*....|....*....|....*....|....
gi 880920401 453 LGLAIVSGILAAHRGNASLskTKGGGLTVRIELP 486
Cdd:COG3920 458 LGLRLIRALVRQLGGTLEL--DRPEGTRVRITFP 489
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
373-461 |
6.29e-03 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 36.88 E-value: 6.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 880920401 373 LIIPGDRDRISQVFTNLIGNIVRY---TPEGSPVEIALGRSSDTAIVELRDHGPGIDETDRgrvfERFYRADSSRNRKSG 449
Cdd:pfam13581 23 GLPEELLDEVELAVGEACTNAVEHayrEGPEGPVEVRLTSDGGGLVVTVADSGPPFDPLTL----PPPDLEEPDEDRKEG 98
|
90
....*....|..
gi 880920401 450 gsGLGLAIVSGI 461
Cdd:pfam13581 99 --GRGLALIRGL 108
|
|
| |
