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Conserved domains on  [gi|881012846|ref|WP_048733555|]
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MULTISPECIES: S9 family peptidase [Corynebacterium]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 11445445)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
8-252 2.11e-34

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


:

Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 123.59  E-value: 2.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   8 FTGSTGETLAASIDLP-DGQPRAWALFGHCFTCNRMvPGASRTCKALAKKGIAAFRFDFTGLGQSTGDFGETtfqtNIDD 86
Cdd:COG1506    2 FKSADGTTLPGWLYLPaDGKKYPVVVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGD----EVDD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  87 LKAAYEFMEAEFEAPS---LLIGHSLGGAAALN-AGHDMPKIKAVATIGAPFDPAHSIvriagdistvdeHGTQVLQIEG 162
Cdd:COG1506   77 VLAAIDYLAARPYVDPdriGIYGHSYGGYMALLaAARHPDRFKAAVALAGVSDLRSYY------------GTTREYTERL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846 163 RGIPisREFLEVLADYNPEVYLSQLRKPLLILHSPTDQTVGIDSAQKIFQVSRY---PKSLMSLDRADHLLTRaKSAARA 239
Cdd:COG1506  145 MGGP--WEDPEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagkPVELLVYPGEGHGFSG-AGAPDY 221

                        250
                 ....*....|...
gi 881012846 240 ADLIYAWADSYLP 252
Cdd:COG1506  222 LERILDFLDRHLK 234
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
8-252 2.11e-34

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 123.59  E-value: 2.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   8 FTGSTGETLAASIDLP-DGQPRAWALFGHCFTCNRMvPGASRTCKALAKKGIAAFRFDFTGLGQSTGDFGETtfqtNIDD 86
Cdd:COG1506    2 FKSADGTTLPGWLYLPaDGKKYPVVVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGD----EVDD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  87 LKAAYEFMEAEFEAPS---LLIGHSLGGAAALN-AGHDMPKIKAVATIGAPFDPAHSIvriagdistvdeHGTQVLQIEG 162
Cdd:COG1506   77 VLAAIDYLAARPYVDPdriGIYGHSYGGYMALLaAARHPDRFKAAVALAGVSDLRSYY------------GTTREYTERL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846 163 RGIPisREFLEVLADYNPEVYLSQLRKPLLILHSPTDQTVGIDSAQKIFQVSRY---PKSLMSLDRADHLLTRaKSAARA 239
Cdd:COG1506  145 MGGP--WEDPEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagkPVELLVYPGEGHGFSG-AGAPDY 221

                        250
                 ....*....|...
gi 881012846 240 ADLIYAWADSYLP 252
Cdd:COG1506  222 LERILDFLDRHLK 234
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 47-142 8.79e-11

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 60.31  E-value: 8.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   47 SRTCKALAKKGIAAFRFDFTGLGQSTGDFGE-TTFQTNIDDLKAAYEFMEAEF-EAPSLLIGHSLGGAAALNAGHDMP-K 123
Cdd:pfam12146  21 AHLADALAAQGFAVYAYDHRGHGRSDGKRGHvPSFDDYVDDLDTFVDKIREEHpGLPLFLLGHSMGGLIAALYALRYPdK 100

                          90
                  ....*....|....*....
gi 881012846  124 IKAVATIGAPFDPAHSIVR 142
Cdd:pfam12146 101 VDGLILSAPALKIKPYLAP 119
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 39-122 4.76e-07

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 49.43  E-value: 4.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   39 CNRMVPGASRtckALAKKGIAAFRFDFTGLGQSTGDFGETTFQTNIDDLKAAYEFMEAEFEAPSLLIGHSLGGAAALNAG 118
Cdd:TIGR03101  41 SRRMVALQAR---AFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQGHPPVTLWGLRLGALLALDAA 117


                  ....
gi 881012846  119 HDMP 122
Cdd:TIGR03101 118 NPLA 121
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 23-147 1.30e-05

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 45.51  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  23 PDGQPRAWALFGHCF--TCNRMVPGASRTckaLAKKGIAAFRFDFTGLGQSTGDFGE-TTFQTNIDDLKAAYEFMEAEFE 99
Cdd:PLN02385  82 ENSRPKAAVCFCHGYgdTCTFFFEGIARK---IASSGYGVFAMDYPGFGLSEGLHGYiPSFDDLVDDVIEHYSKIKGNPE 158

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 881012846 100 ---APSLLIGHSLGGAAALNAGHDMPKIKAVATIGAPfdpahsIVRIAGDI 147
Cdd:PLN02385 159 frgLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAP------MCKIADDV 203
 
Name Accession Description Interval E-value
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
8-252 2.11e-34

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 123.59  E-value: 2.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   8 FTGSTGETLAASIDLP-DGQPRAWALFGHCFTCNRMvPGASRTCKALAKKGIAAFRFDFTGLGQSTGDFGETtfqtNIDD 86
Cdd:COG1506    2 FKSADGTTLPGWLYLPaDGKKYPVVVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGD----EVDD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  87 LKAAYEFMEAEFEAPS---LLIGHSLGGAAALN-AGHDMPKIKAVATIGAPFDPAHSIvriagdistvdeHGTQVLQIEG 162
Cdd:COG1506   77 VLAAIDYLAARPYVDPdriGIYGHSYGGYMALLaAARHPDRFKAAVALAGVSDLRSYY------------GTTREYTERL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846 163 RGIPisREFLEVLADYNPEVYLSQLRKPLLILHSPTDQTVGIDSAQKIFQVSRY---PKSLMSLDRADHLLTRaKSAARA 239
Cdd:COG1506  145 MGGP--WEDPEAYAARSPLAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKagkPVELLVYPGEGHGFSG-AGAPDY 221

                        250
                 ....*....|...
gi 881012846 240 ADLIYAWADSYLP 252
Cdd:COG1506  222 LERILDFLDRHLK 234
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
35-250 1.50e-29

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 111.19  E-value: 1.50e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  35 HCFTCN----RMVPgasrtcKALAKKGIAAFRFDFTGLGQSTGDFGETTFQTNIDDLKAAYEFMEAEFEAPSlLIGHSLG 110
Cdd:COG1647   22 HGFTGSpaemRPLA------EALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEILKAGYDKVI-VIGLSMG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846 111 GAAALNAGHDMPKIKAVATIGAPFDPAHSIVRIA-----------GDISTVDEHGTQVLQIEGRGIPISREFLEVLADYN 179
Cdd:COG1647   95 GLLALLLAARYPDVAGLVLLSPALKIDDPSAPLLpllkylarslrGIGSDIEDPEVAEYAYDRTPLRALAELQRLIREVR 174

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 881012846 180 PEvyLSQLRKPLLILHSPTDQTVGIDSAQKIF-QVSRYPKSLMSLDRADHLLTRAKSAARAADLIYAWADSY 250
Cdd:COG1647  175 RD--LPKITAPTLIIQSRKDEVVPPESARYIYeRLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFLERL 244
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-249 3.45e-25

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 98.92  E-value: 3.45e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   1 MPTKHLKFTGSTGETLAASIDLPDGQPRAWALFGHCFT--CNRMvpgaSRTCKALAKKGIAAFRFDFTGLGQSTGDFGE- 77
Cdd:COG2267    1 MTRRLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGehSGRY----AELAEALAAAGYAVLAFDLRGHGRSDGPRGHv 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  78 TTFQTNIDDLKAAYEFMEAEFEAPSLLIGHSLGGAAALNAGHDMP-KIKAVATIGAPFDPAhsivriagdistvdehgtq 156
Cdd:COG2267   77 DSFDDYVDDLRAALDALRARPGLPVVLLGHSMGGLIALLYAARYPdRVAGLVLLAPAYRAD------------------- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846 157 vlqiegrgiPISREFLEVLADYNPEVYLSQLRKPLLILHSPTDQTVGIDSAQKIFQVSRYPKSLMSLDRADHLLTRAKSA 236
Cdd:COG2267  138 ---------PLLGPSARWLRALRLAEALARIDVPVLVLHGGADRVVPPEAARRLAARLSPDVELVLLPGARHELLNEPAR 208

                        250
                 ....*....|...
gi 881012846 237 ARAADLIYAWADS 249
Cdd:COG2267  209 EEVLAAILAWLER 221
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 1-251 2.89e-24

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 97.29  E-value: 2.89e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   1 MPTKHLKFTGSTGETLAASIDLPDG--QPRAWALFGHCFTCNR--MVPGAsrtcKALAKKGIAAFRFDFTGLGQSTGDFG 76
Cdd:COG1073    8 VNKEDVTFKSRDGIKLAGDLYLPAGasKKYPAVVVAHGNGGVKeqRALYA----QRLAELGFNVLAFDYRGYGESEGEPR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  77 ETTFQTnIDDLKAAYEFMEAEFEAPS---LLIGHSLGGAAALNAGHDMPKIKAVATIgAPFDpahSIVRIAGDistvdeh 153
Cdd:COG1073   84 EEGSPE-RRDARAAVDYLRTLPGVDPeriGLLGISLGGGYALNAAATDPRVKAVILD-SPFT---SLEDLAAQ------- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846 154 gtQVLQIEGRGIPIS-----REFLEVLAD-YNPEVYLSQLRKPLLILHSPTDQTVGIDSAQKIFQVSRYPKSLMSLDRAD 227
Cdd:COG1073  152 --RAKEARGAYLPGVpylpnVRLASLLNDeFDPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAG 229

                        250       260
                 ....*....|....*....|....
gi 881012846 228 HLLTRAKSAARAADLIYAWADSYL 251
Cdd:COG1073  230 HVDLYDRPEEEYFDKLAEFFKKNL 253
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
5-229 6.93e-19

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 81.75  E-value: 6.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   5 HLKFTGSTGeTLAASIDLPDGQPRAWALFGH------CFTCNRMVPGASRTCKALakkGIAAFRFDFTGLGQSTGDF--- 75
Cdd:COG2945    1 KVLINGPAG-RLEGRLDLPEGPPRGVALILHphplfgGTMDNKVVYTLARALVAA---GFAVLRFNFRGVGRSEGEFdeg 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  76 -GETtfqtniDDLKAAYEFMEAEFEAPSLLIGHSLGGAAALNAGHDMPKIKAVATIGAPFDpahsivriagdistvdehg 154
Cdd:COG2945   77 rGEL------DDAAAALDWLRAQNPLPLWLAGFSFGAYVALQLAMRLPEVEGLILVAPPVN------------------- 131

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 881012846 155 tqvlqiegrgipisreflevLADYNPevyLSQLRKPLLILHSPTDQTVGIDSAQKIFQVSRYPKSLMSLDRADHL 229
Cdd:COG2945  132 --------------------RYDFSF---LAPCPAPTLVIHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADHF 183
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 47-142 8.79e-11

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 60.31  E-value: 8.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   47 SRTCKALAKKGIAAFRFDFTGLGQSTGDFGE-TTFQTNIDDLKAAYEFMEAEF-EAPSLLIGHSLGGAAALNAGHDMP-K 123
Cdd:pfam12146  21 AHLADALAAQGFAVYAYDHRGHGRSDGKRGHvPSFDDYVDDLDTFVDKIREEHpGLPLFLLGHSMGGLIAALYALRYPdK 100

                          90
                  ....*....|....*....
gi 881012846  124 IKAVATIGAPFDPAHSIVR 142
Cdd:pfam12146 101 VDGLILSAPALKIKPYLAP 119
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 62-249 9.54e-11

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 60.01  E-value: 9.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  62 RFDFTGLGQSTGDFGETTFQTNIDDLKAayeFMEAEFEAPSLLIGHSLGGAAALNAGHDMP-KIKAVATIGAPFDPAHsi 140
Cdd:COG0596   54 APDLRGHGRSDKPAGGYTLDDLADDLAA---LLDALGLERVVLVGHSMGGMVALELAARHPeRVAGLVLVDEVLAALA-- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846 141 vriagdistvdehgtQVLQIEGRGIPISREFLEVLADYNPEVYLSQLRKPLLILHSPTDQTVGIDSAQKIfqVSRYPKS- 219
Cdd:COG0596  129 ---------------EPLRRPGLAPEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRL--AELLPNAe 191

                        170       180       190
                 ....*....|....*....|....*....|
gi 881012846 220 LMSLDRADHLLTRAKsAARAADLIYAWADS 249
Cdd:COG0596  192 LVVLPGAGHFPPLEQ-PEAFAAALRDFLAR 220
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
13-132 8.49e-10

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 57.97  E-value: 8.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  13 GETLAASIDLPDGQPRAWALFgHCFTCnrmVPGA--SRTCKALAKKGIAAFRFDFTGLGQST-----------GDFGEtt 79
Cdd:COG4757   17 GYPLAARLFPPAGPPRAVVLI-NPATG---VPQRfyRPFARYLAERGFAVLTYDYRGIGLSRpgslrgfdagyRDWGE-- 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 881012846  80 fqtniDDLKAAYEFMEAEF-EAPSLLIGHSLGG-AAALNAGHDmpKIKAVATIGA 132
Cdd:COG4757   91 -----LDLPAVLDALRARFpGLPLLLVGHSLGGqLLGLAPNAE--RVDRLVTVAS 138
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
1-246 8.64e-08

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 51.51  E-value: 8.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   1 MPTKHLKFTGSTGETLAASIDLPDGQ-PRAWALFGH-CFTcnrMVPGASRTCKALAKKGIAAF---RFDFTGLGQSTGDF 75
Cdd:COG0412    1 MTTETVTIPTPDGVTLPGYLARPAGGgPRPGVVVLHeIFG---LNPHIRDVARRLAAAGYVVLapdLYGRGGPGDDPDEA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  76 GETTFQTNID----DLKAAYEFMEAEFEAPSL---LIGHSLGGAAALNAGHDMPKIKAVATIgapfdpahsivriagdis 148
Cdd:COG0412   78 RALMGALDPEllaaDLRAALDWLKAQPEVDAGrvgVVGFCFGGGLALLAAARGPDLAAAVSF------------------ 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846 149 tvdeHGTQVLQiegrgipisreflevladyNPEVYLSQLRKPLLILHSPTDQTVGIDSAQKIFQ---VSRYPKSLMSLDR 225
Cdd:COG0412  140 ----YGGLPAD-------------------DLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAalaAAGVDVELHVYPG 196

                        250       260
                 ....*....|....*....|....*...
gi 881012846 226 ADHLLTR-------AKSAARAADLIYAW 246
Cdd:COG0412  197 AGHGFTNpgrprydPAAAEDAWQRTLAF 224
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 39-122 4.76e-07

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 49.43  E-value: 4.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   39 CNRMVPGASRtckALAKKGIAAFRFDFTGLGQSTGDFGETTFQTNIDDLKAAYEFMEAEFEAPSLLIGHSLGGAAALNAG 118
Cdd:TIGR03101  41 SRRMVALQAR---AFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQGHPPVTLWGLRLGALLALDAA 117


                  ....
gi 881012846  119 HDMP 122
Cdd:TIGR03101 118 NPLA 121
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 23-147 1.30e-05

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 45.51  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  23 PDGQPRAWALFGHCF--TCNRMVPGASRTckaLAKKGIAAFRFDFTGLGQSTGDFGE-TTFQTNIDDLKAAYEFMEAEFE 99
Cdd:PLN02385  82 ENSRPKAAVCFCHGYgdTCTFFFEGIARK---IASSGYGVFAMDYPGFGLSEGLHGYiPSFDDLVDDVIEHYSKIKGNPE 158

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 881012846 100 ---APSLLIGHSLGGAAALNAGHDMPKIKAVATIGAPfdpahsIVRIAGDI 147
Cdd:PLN02385 159 frgLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAP------MCKIADDV 203
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 51-188 1.98e-05

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 45.27  E-value: 1.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  51 KALAKKGIAAFRFDFTGLGQSTGDFGET-TFQTNIDDLKAAYEFMEAEFEA-PSLLIGHSLGGAAALNAGhDMPKIKAV- 127
Cdd:PLN02652 157 KQLTSCGFGVYAMDWIGHGGSDGLHGYVpSLDYVVEDTEAFLEKIRSENPGvPCFLFGHSTGGAVVLKAA-SYPSIEDKl 235

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 881012846 128 --ATIGAP---FDPAHSIVRIAGDISTVDEHGTQVLQIEGRGIPISREFLEVLADY-NPEVYLSQLR 188
Cdd:PLN02652 236 egIVLTSPalrVKPAHPIVGAVAPIFSLVAPRFQFKGANKRGIPVSRDPAALLAKYsDPLVYTGPIR 302
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 42-155 5.40e-05

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 43.23  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   42 MVPGASRTCKALAK---KGIAAFRFDFTGLGQSTGDfgettfQTNIDDLKAAYEFMEAEFEA-PSLLIGHSLGGAAALNA 117
Cdd:pfam12697   3 LVHGAGLSAAPLAAllaAGVAVLAPDLPGHGSSSPP------PLDLADLADLAALLDELGAArPVVLVGHSLGGAVALAA 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 881012846  118 GHDMPKIK-AVATIGAPFDPAHSIVRIAGDISTVDEHGT 155
Cdd:pfam12697  77 AAAALVVGvLVAPLAAPPGLLAALLALLARLGAALAAPA 115
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 51-147 1.59e-03

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.02  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846   51 KALAKKGIAAFRFDFTGLGQSTGDFGETTFQTniDDLKAAYEFMEAEFEAPSL-LIGHSLGGAAALNAGHDMP-KIKAVA 128
Cdd:pfam00561  21 PALARDGFRVIALDLRGFGKSSRPKAQDDYRT--DDLAEDLEYILEALGLEKVnLVGHSMGGLIALAYAAKYPdRVKALV 98

                          90
                  ....*....|....*....
gi 881012846  129 TIGAPfDPAHSIVRIAGDI 147
Cdd:pfam00561  99 LLGAL-DPPHELDEADRFI 116
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 63-122 1.93e-03

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 39.16  E-value: 1.93e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 881012846  63 FDFTGLGQSTGDFGETTfqtnIDDLKAAYE-FMEAEFEAPSLLIGHSLGGAAALNAGHDMP 122
Cdd:PRK14875 163 LDLPGHGASSKAVGAGS----LDELAAAVLaFLDALGIERAHLVGHSMGGAVALRLAARAP 219
COG4814 COG4814
Uncharacterized conserved protein with an alpha/beta hydrolase fold [Function unknown];
80-212 2.66e-03

Uncharacterized conserved protein with an alpha/beta hydrolase fold [Function unknown];


Pssm-ID: 443842  Cd Length: 286  Bit Score: 38.38  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 881012846  80 FQTNIDD-------LKAAYEFMEAEFEAPSL-LIGHSLGGAAALNAG------HDMPKIKAVATIGAPFDpahsivriag 145
Cdd:COG4814  106 FEDNRDSikkqakwLKKVLKYLKKKYGFKKFnAVGHSMGGLALTYYLekygndKSLPKLNKLVTIGGPFN---------- 175

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 881012846 146 DISTVDEHGTQVLQIEGRGIPISREFLEVLADYNpevYLSQLRKPLLI-----LHSPTDQTVGIDSAQ---KIFQ 212
Cdd:COG4814  176 GIENEDNNNLTDLLADGKPKPKTQAYKDLIKNRD---KFPKNLQVLNIagdlnDGTDSDGIVPLASVLsgkYIFQ 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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