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Conserved domains on  [gi|889506950|ref|WP_048822473|]
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filamentous hemagglutinin N-terminal domain-containing protein [Morganella morganii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPS super family cl47936
TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the ...
 32-276 3.56e-18

TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens.


The actual alignment was detected with superfamily member pfam05860:

Pssm-ID: 461762 [Multi-domain]  Cd Length: 249  Bit Score: 83.52  E-value: 3.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950   32 KITADQASPEVNIRIKDNK---PTQSISTPNSNGISHNYFTEFNVGKNGLNIDNSP-SARVIINEVTGTNISQLDGTMAI 107
Cdd:pfam05860   2 QITPDGTLPTNGPTVLQTGngvPIVNIATPNAGGNLFNSFSQFNVGPGGAVLFNSPtDAQNILNRVTGGNPSQIQGYIEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950  108 IGKQASLVIANPNGVNCNSCGVSNVSHLTLLAGNTSLDVTTGKLIGFKNITNNVIV--SNVKKNAIKSNLTLTGNSVEIN 185
Cdd:pfam05860  82 NGTRANLFLANPNGIIFGGNAFINIGGSFLTTTAPSIKFGDGTEFNPSSVPLGTVSvpGGGQFGSNGGYIDLIARAVDNN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950  186 SSYVNSphTTINIGADNIDLK-NNLNSQISDIKLTPGKVVNSSGSYSNSLidSDTKIRGKMTVNAKNATLtNNGNIILSE 264
Cdd:pfam05860 162 GQVPAG--KTLALVAGNNDVDgGAPGGRVEIGSVTAAGTVAIDAASLGSM--YAGNIRLIGTDKGAGVRL-ANGSLVASG 236

                         250
                  ....*....|..
gi 889506950  265 VNLNLLHSELIN 276
Cdd:pfam05860 237 GDLNGTSAGDIQ 248
 
Name Accession Description Interval E-value
TPS pfam05860
TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the ...
 32-276 3.56e-18

TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens.


Pssm-ID: 461762 [Multi-domain]  Cd Length: 249  Bit Score: 83.52  E-value: 3.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950   32 KITADQASPEVNIRIKDNK---PTQSISTPNSNGISHNYFTEFNVGKNGLNIDNSP-SARVIINEVTGTNISQLDGTMAI 107
Cdd:pfam05860   2 QITPDGTLPTNGPTVLQTGngvPIVNIATPNAGGNLFNSFSQFNVGPGGAVLFNSPtDAQNILNRVTGGNPSQIQGYIEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950  108 IGKQASLVIANPNGVNCNSCGVSNVSHLTLLAGNTSLDVTTGKLIGFKNITNNVIV--SNVKKNAIKSNLTLTGNSVEIN 185
Cdd:pfam05860  82 NGTRANLFLANPNGIIFGGNAFINIGGSFLTTTAPSIKFGDGTEFNPSSVPLGTVSvpGGGQFGSNGGYIDLIARAVDNN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950  186 SSYVNSphTTINIGADNIDLK-NNLNSQISDIKLTPGKVVNSSGSYSNSLidSDTKIRGKMTVNAKNATLtNNGNIILSE 264
Cdd:pfam05860 162 GQVPAG--KTLALVAGNNDVDgGAPGGRVEIGSVTAAGTVAIDAASLGSM--YAGNIRLIGTDKGAGVRL-ANGSLVASG 236

                         250
                  ....*....|..
gi 889506950  265 VNLNLLHSELIN 276
Cdd:pfam05860 237 GDLNGTSAGDIQ 248
adhes_NPXG TIGR01901
filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain ...
 65-143 2.47e-10

filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain found near the N-terminus of a number of large, repetitive bacterial proteins, including many proteins of over 2500 amino acids. Members generally have a signal sequence, then an intervening region, then the region described by this model. Following this region, proteins typically have regions rich in repeats but may show no homology between the repeats of one member and the repeats of another. A number of the members of this family have been designated adhesins, filamentous haemagglutinins, heme/hemopexin-binding protein, etc.


Pssm-ID: 273865  Cd Length: 79  Bit Score: 56.52  E-value: 2.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950   65 HNYFTEFNVGKNG-LNIDNSPSARVIINEVTGTNISQLDGTMAIIGKqASLVIANPNGVNCNSCGVSNVSHLTLLAGNTS 143
Cdd:TIGR01901   1 FNNWQQFNVGQGGtVTFNQPPAASNILNRVTGGSASQIQGLLQVNGK-ANVFLINPNGIIFGGGAQINVGGLVASTTAIS 79
Haemagg_act smart00912
haemagglutination activity domain; This domain is suggested to be a carbohydrate- dependent ...
 36-145 1.48e-09

haemagglutination activity domain; This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.


Pssm-ID: 214908 [Multi-domain]  Cd Length: 119  Bit Score: 55.36  E-value: 1.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950    36 DQASPEVNIRIKDNKPTQSISTPNSNGI-----SHNYFTEFNVGKNGL-NIDNSPSARVIINEVTGTNISQLDGTMAIIG 109
Cdd:smart00912   1 ANGLPVVNIVTPNSHNQYSSFNVGTRGVnqilnNAINWQSFSVGAGETvNFNQPGSASVILNRVTGGNPSQINGALEVAG 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 889506950   110 KQASLVIANPNGVNCNSCGVS-NVSHLTLLAGNTSLD 145
Cdd:smart00912  81 KAAGVVFLNNPGGIVFGCGAIvNVGGVTVATTLPIID 117
 
Name Accession Description Interval E-value
TPS pfam05860
TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the ...
 32-276 3.56e-18

TPS secretion domain; Filamentous hemagglutinin (FHA), the major 230-kDa adhesin of the whooping cough agent Bordetella pertussis, is one of the most efficiently secreted proteins in Gram-negative bacteria. FHA is secreted by means of the two-partner secretion (TPS) pathway. A TPS system is composed of two separate proteins, with TpsA the secreted protein and TpsB its associated specific outer-membrane transporter. All TPS-secreted proteins contain a distinctive N-proximal module essential for secretion, the TPS domain. The TPS domain folds into a beta-helix. This domain is found in a wide variety of secreted proteins from bacterial pathogens.


Pssm-ID: 461762 [Multi-domain]  Cd Length: 249  Bit Score: 83.52  E-value: 3.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950   32 KITADQASPEVNIRIKDNK---PTQSISTPNSNGISHNYFTEFNVGKNGLNIDNSP-SARVIINEVTGTNISQLDGTMAI 107
Cdd:pfam05860   2 QITPDGTLPTNGPTVLQTGngvPIVNIATPNAGGNLFNSFSQFNVGPGGAVLFNSPtDAQNILNRVTGGNPSQIQGYIEA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950  108 IGKQASLVIANPNGVNCNSCGVSNVSHLTLLAGNTSLDVTTGKLIGFKNITNNVIV--SNVKKNAIKSNLTLTGNSVEIN 185
Cdd:pfam05860  82 NGTRANLFLANPNGIIFGGNAFINIGGSFLTTTAPSIKFGDGTEFNPSSVPLGTVSvpGGGQFGSNGGYIDLIARAVDNN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950  186 SSYVNSphTTINIGADNIDLK-NNLNSQISDIKLTPGKVVNSSGSYSNSLidSDTKIRGKMTVNAKNATLtNNGNIILSE 264
Cdd:pfam05860 162 GQVPAG--KTLALVAGNNDVDgGAPGGRVEIGSVTAAGTVAIDAASLGSM--YAGNIRLIGTDKGAGVRL-ANGSLVASG 236

                         250
                  ....*....|..
gi 889506950  265 VNLNLLHSELIN 276
Cdd:pfam05860 237 GDLNGTSAGDIQ 248
adhes_NPXG TIGR01901
filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain ...
 65-143 2.47e-10

filamentous hemagglutinin family N-terminal domain; This model represents a conserved domain found near the N-terminus of a number of large, repetitive bacterial proteins, including many proteins of over 2500 amino acids. Members generally have a signal sequence, then an intervening region, then the region described by this model. Following this region, proteins typically have regions rich in repeats but may show no homology between the repeats of one member and the repeats of another. A number of the members of this family have been designated adhesins, filamentous haemagglutinins, heme/hemopexin-binding protein, etc.


Pssm-ID: 273865  Cd Length: 79  Bit Score: 56.52  E-value: 2.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950   65 HNYFTEFNVGKNG-LNIDNSPSARVIINEVTGTNISQLDGTMAIIGKqASLVIANPNGVNCNSCGVSNVSHLTLLAGNTS 143
Cdd:TIGR01901   1 FNNWQQFNVGQGGtVTFNQPPAASNILNRVTGGSASQIQGLLQVNGK-ANVFLINPNGIIFGGGAQINVGGLVASTTAIS 79
Haemagg_act smart00912
haemagglutination activity domain; This domain is suggested to be a carbohydrate- dependent ...
 36-145 1.48e-09

haemagglutination activity domain; This domain is suggested to be a carbohydrate- dependent haemagglutination activity site. It is found in a range of haemagglutinins and haemolysins.


Pssm-ID: 214908 [Multi-domain]  Cd Length: 119  Bit Score: 55.36  E-value: 1.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 889506950    36 DQASPEVNIRIKDNKPTQSISTPNSNGI-----SHNYFTEFNVGKNGL-NIDNSPSARVIINEVTGTNISQLDGTMAIIG 109
Cdd:smart00912   1 ANGLPVVNIVTPNSHNQYSSFNVGTRGVnqilnNAINWQSFSVGAGETvNFNQPGSASVILNRVTGGNPSQINGALEVAG 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 889506950   110 KQASLVIANPNGVNCNSCGVS-NVSHLTLLAGNTSLD 145
Cdd:smart00912  81 KAAGVVFLNNPGGIVFGCGAIvNVGGVTVATTLPIID 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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