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Conserved domains on  [gi|893685778|ref|WP_048924970|]
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GntR family transcriptional regulator [Faecalibacillus faecis]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-232 1.89e-61

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 192.38  E-value: 1.89e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKdydastedANHLKQS 82
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA--------EPKIEYP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  83 GLGLTR-----KLEGKSnLKSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEH 157
Cdd:COG2188   78 LSRLTSfteelRARGRE-PSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEED 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893685778 158 L-KGSIYQYIEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFELQ 232
Cdd:COG2188  157 LeTGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV 232
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-232 1.89e-61

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 192.38  E-value: 1.89e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKdydastedANHLKQS 82
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA--------EPKIEYP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  83 GLGLTR-----KLEGKSnLKSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEH 157
Cdd:COG2188   78 LSRLTSfteelRARGRE-PSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEED 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893685778 158 L-KGSIYQYIEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFELQ 232
Cdd:COG2188  157 LeTGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV 232
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 97-230 2.53e-39

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 132.80  E-value: 2.53e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778    97 KSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHLKGSIYQYIEKELKLKIQS 176
Cdd:smart00866   7 TTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGLKIVR 86

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 893685778   177 T---HKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFE 230
Cdd:smart00866  87 StraEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 95-230 9.74e-35

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 120.78  E-value: 9.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   95 NLKSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHL-KGSIYQYIEKELKLK 173
Cdd:pfam07702   5 EPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEERYGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 893685778  174 IQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFE 230
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 3-229 1.04e-32

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 118.62  E-value: 1.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778    3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDYDASTedanhLKQS 82
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIE-----FPIS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   83 GLGLTRKLEGKSNLKS--EIIEFSV-IPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHLK 159
Cdd:TIGR02404  76 GITSFKELNETLGLDSktEVVELDKeDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAE 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  160 GSIYQYIEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNF 229
Cdd:TIGR02404 156 DSIYQYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKF 225
PRK09764 PRK09764
GntR family transcriptional regulator;
3-234 8.09e-31

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 113.77  E-value: 8.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDydastEDANHLKQS 82
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE-----ERVNYDIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  83 GLGLTRKLEGKS-NLKSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHLKGS 161
Cdd:PRK09764  81 LTSFDEKLSDRHvDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 893685778 162 IYQYIEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFELQTV 234
Cdd:PRK09764 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLI 233
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 3-67 1.35e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 71.32  E-value: 1.35e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 893685778   3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVK 67
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
3-232 1.89e-61

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 192.38  E-value: 1.89e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKdydastedANHLKQS 82
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA--------EPKIEYP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  83 GLGLTR-----KLEGKSnLKSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEH 157
Cdd:COG2188   78 LSRLTSfteelRARGRE-PSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEED 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893685778 158 L-KGSIYQYIEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFELQ 232
Cdd:COG2188  157 LeTGSLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFV 232
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 97-230 2.53e-39

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 132.80  E-value: 2.53e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778    97 KSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHLKGSIYQYIEKELKLKIQS 176
Cdd:smart00866   7 TTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGLKIVR 86

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 893685778   177 T---HKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFE 230
Cdd:smart00866  87 StraEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 95-230 9.74e-35

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 120.78  E-value: 9.74e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   95 NLKSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHL-KGSIYQYIEKELKLK 173
Cdd:pfam07702   5 EPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEERYGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 893685778  174 IQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFE 230
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 3-229 1.04e-32

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 118.62  E-value: 1.04e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778    3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDYDASTedanhLKQS 82
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIE-----FPIS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   83 GLGLTRKLEGKSNLKS--EIIEFSV-IPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHLK 159
Cdd:TIGR02404  76 GITSFKELNETLGLDSktEVVELDKeDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAE 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  160 GSIYQYIEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNF 229
Cdd:TIGR02404 156 DSIYQYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKF 225
PRK09764 PRK09764
GntR family transcriptional regulator;
3-234 8.09e-31

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 113.77  E-value: 8.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDydastEDANHLKQS 82
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKE-----ERVNYDIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  83 GLGLTRKLEGKS-NLKSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHLKGS 161
Cdd:PRK09764  81 LTSFDEKLSDRHvDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENS 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 893685778 162 IYQYIEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYNNFELQTV 234
Cdd:PRK09764 161 KYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLI 233
PRK11402 PRK11402
transcriptional regulator PhoB;
7-227 6.84e-28

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 106.07  E-value: 6.84e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   7 IADDIRSKIfdkkYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDYDASTEdanHLKQSGLGL 86
Cdd:PRK11402  18 LLDDIAQGV----YQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENA---LLTVSGFTD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  87 TRKLEGKSNlKSEIIEFSvIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKlEHLKG--SIYQ 164
Cdd:PRK11402  91 FGVSQGKAT-KEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFD-EIYVEgsSTYQ 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 893685778 165 YIEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRYHYN 227
Cdd:PRK11402 168 LFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRAN 230
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 7-224 3.00e-19

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 83.29  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778    7 IADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDyDASTEDANHLKQSGLGL 86
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAA-RRIDYPLSARTRFSQNL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   87 trkLEGKSNLKSEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPNLKLEHLK-GSIYQY 165
Cdd:TIGR02325  92 ---ADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAAsGSITDA 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 893685778  166 IEKELKLKIQSTHKTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGIIFEYSFTRY 224
Cdd:TIGR02325 169 LREQGVADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRF 227
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 3-67 1.35e-16

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 71.32  E-value: 1.35e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 893685778   3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVK 67
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 20-201 2.01e-15

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 72.89  E-value: 2.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  20 YTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFV--KDYDASTEDANHLKQSglgltrKLEGKSNLK 97
Cdd:PRK10079  29 YRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVlmRPYDYPLNAQARFSQN------LLDQGSHPT 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  98 SEIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMP-ISIIPNLKLEHlKGSIYQYIEKELKLKIQS 176
Cdd:PRK10079 103 SEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFAdLTWWPTLQRFD-SGSLHDFLREQLGIALRR 181

                        170       180
                 ....*....|....*....|....*
gi 893685778 177 THKTIRAHLSSPLEQENLGLKEYEP 201
Cdd:PRK10079 182 SQTRISARRAQAKESQLLEIPNMSP 206
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 3-66 9.38e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 56.08  E-value: 9.38e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 893685778    3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFV 66
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
4-68 9.60e-11

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 57.11  E-value: 9.60e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 893685778   4 YIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKD 68
Cdd:COG1725   12 YEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
7-66 2.96e-10

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 54.50  E-value: 2.96e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778     7 IADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFV 66
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 3-68 1.76e-09

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 57.15  E-value: 1.76e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893685778   3 KYIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKD 68
Cdd:COG1167   13 LYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-72 1.93e-08

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 53.01  E-value: 1.93e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 893685778   4 YIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDYDAS 72
Cdd:COG2186    9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPW 77
PRK10225 PRK10225
Uxu operon transcriptional regulator;
4-120 2.93e-08

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 52.72  E-value: 2.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   4 YIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDYDASTE----DANHL 79
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNtdspDANVC 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 893685778  80 KQSglGLTRKLEGKSNLKSEIIEFSVI-PSDEHISKR---LQIEE 120
Cdd:PRK10225  91 NDA--GPFELLQARQLLESNIAEFAALqATREDIVKMrqaLQLEE 133
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 6-67 6.04e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 45.91  E-value: 6.04e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 893685778   6 DIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVK 67
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIR 67
PRK14999 PRK14999
histidine utilization repressor; Provisional
 4-216 1.47e-05

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 44.92  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778   4 YIDIADDIRSKIFDKKYTYGQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVkdydastedANHLKQSG 83
Cdd:PRK14999  14 YETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV---------AEPKGQSA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893685778  84 LGLTRKLEGKSNLKS-----EIIEFSVIPSDEHISKRLQIEEGSFVYHIIRKRIVDDKPYCLEITYMPISIIPN-LKLEH 157
Cdd:PRK14999  85 LFEVRSIAEEIAARRhqhrcEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDyLTQDY 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 893685778 158 LKGSIYQYIEKELKLKiQSTHkTIRAHLSSPLEQENLGLKEYEPYIEVEQTAYLSSGII 216
Cdd:PRK14999 165 RQTTPHAYLSRIAPLT-EGEH-IVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIV 221
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
23-68 1.24e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 39.23  E-value: 1.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 893685778  23 GQKLPYEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKD 68
Cdd:PRK09464  31 GEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
7-79 3.90e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 37.21  E-value: 3.90e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 893685778   7 IADDIRSKIFDKKYTYGQKLPyEYVLCVAYHCNKETMKKALDILVKEGLIVRRRGAGTFVKDYDAstEDANHL 79
Cdd:COG1802   16 VYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSP--EEIREL 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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