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Conserved domains on  [gi|896153305|ref|WP_049169910|]
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MULTISPECIES: monovalent cation/H+ antiporter complex subunit F [Corynebacterium]

Protein Classification

Na(+)/H(+) antiporter subunit F1( domain architecture ID 10012986)

Na(+)/H(+) antiporter subunit F1/F (MrpF1/MrpF) is a component of Mnh complex, a Na(+)/H(+) antiporter involved in Na(+) excretion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK07948 PRK07948
putative monovalent cation/H+ antiporter subunit F; Reviewed
 6-89 3.77e-25

putative monovalent cation/H+ antiporter subunit F; Reviewed


:

Pssm-ID: 181179  Cd Length: 86  Bit Score: 91.29  E-value: 3.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896153305   6 FNILLGVAAAGYFIAVMITLGHMIAGPNSLDRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAKF 85
Cdd:PRK07948   1 MTVVLTIAAVFLSLAAILTTYRILAGPNSLDRLVALDTLVAVTMCALATWAAWTLDTTVTNAMTALALIGFIGSVSVARF 80


                 ....
gi 896153305  86 RVPD 89
Cdd:PRK07948  81 RVPD 84
 
Name Accession Description Interval E-value
PRK07948 PRK07948
putative monovalent cation/H+ antiporter subunit F; Reviewed
 6-89 3.77e-25

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 181179  Cd Length: 86  Bit Score: 91.29  E-value: 3.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896153305   6 FNILLGVAAAGYFIAVMITLGHMIAGPNSLDRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAKF 85
Cdd:PRK07948   1 MTVVLTIAAVFLSLAAILTTYRILAGPNSLDRLVALDTLVAVTMCALATWAAWTLDTTVTNAMTALALIGFIGSVSVARF 80


                 ....
gi 896153305  86 RVPD 89
Cdd:PRK07948  81 RVPD 84
MnhF COG2212
Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];
5-85 4.89e-13

Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441814  Cd Length: 84  Bit Score: 60.12  E-value: 4.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896153305   5 VFNILLGVAAAGYFIAVMITLGHMIAGPNSLDRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAK 84
Cdd:COG2212    1 MMTTVLLIALALLALALLLALYRLIRGPTLADRVLALDTLGTNAVALLALLGILTGRPLYLDVALVLALLGFVGTVAFAR 80


                 .
gi 896153305  85 F 85
Cdd:COG2212   81 F 81
MrpF_PhaF pfam04066
Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF ...
 36-85 1.22e-08

Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation. It is also involved in symbiosis in Rhizobium meliloti. MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis. MrpF is thought to be an efflux system for Na+ and cholate. The Mrp system in Bacilli may also have primary energization capacities.


Pssm-ID: 461156  Cd Length: 52  Bit Score: 47.78  E-value: 1.22e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 896153305   36 DRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAKF 85
Cdd:pfam04066   1 DRVVALDTLGTNIVALLALLAILTGRPAYLDVALVLALLGFVGTVAFARF 50
 
Name Accession Description Interval E-value
PRK07948 PRK07948
putative monovalent cation/H+ antiporter subunit F; Reviewed
 6-89 3.77e-25

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 181179  Cd Length: 86  Bit Score: 91.29  E-value: 3.77e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896153305   6 FNILLGVAAAGYFIAVMITLGHMIAGPNSLDRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAKF 85
Cdd:PRK07948   1 MTVVLTIAAVFLSLAAILTTYRILAGPNSLDRLVALDTLVAVTMCALATWAAWTLDTTVTNAMTALALIGFIGSVSVARF 80


                 ....
gi 896153305  86 RVPD 89
Cdd:PRK07948  81 RVPD 84
MnhF COG2212
Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];
5-85 4.89e-13

Multisubunit Na+/H+ antiporter, MnhF subunit [Inorganic ion transport and metabolism];


Pssm-ID: 441814  Cd Length: 84  Bit Score: 60.12  E-value: 4.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896153305   5 VFNILLGVAAAGYFIAVMITLGHMIAGPNSLDRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAK 84
Cdd:COG2212    1 MMTTVLLIALALLALALLLALYRLIRGPTLADRVLALDTLGTNAVALLALLGILTGRPLYLDVALVLALLGFVGTVAFAR 80


                 .
gi 896153305  85 F 85
Cdd:COG2212   81 F 81
MrpF_PhaF pfam04066
Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF ...
 36-85 1.22e-08

Multiple resistance and pH regulation protein F (MrpF / PhaF); Members of the PhaF / MrpF family are predicted to be an integral membrane proteins with three transmembrane regions, involved in regulation of pH. PhaF is part of a potassium efflux system involved in pH regulation. It is also involved in symbiosis in Rhizobium meliloti. MrpF is part of a Na+/H+ antiporter complex, also involved in pH homeostasis. MrpF is thought to be an efflux system for Na+ and cholate. The Mrp system in Bacilli may also have primary energization capacities.


Pssm-ID: 461156  Cd Length: 52  Bit Score: 47.78  E-value: 1.22e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 896153305   36 DRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAKF 85
Cdd:pfam04066   1 DRVVALDTLGTNIVALLALLAILTGRPAYLDVALVLALLGFVGTVAFARF 50
PRK12599 PRK12599
putative monovalent cation/H+ antiporter subunit F; Reviewed
 4-93 7.88e-08

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 237148  Cd Length: 91  Bit Score: 46.83  E-value: 7.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896153305   4 EVFNILLGVAAAGYFIAVMITLGHMIAGPNSLDRLVALESMTAMLQGMLAAFMAWS-----LDTSVVYpmlivALLGFLS 78
Cdd:PRK12599   2 TLLEDAFLIAAVLLVLALILSLYRVILGPTLPDRVVALDTLNTITVGIIAVLAAATgrplyLDIAIVY-----ALLSFLG 76

                         90
                 ....*....|....*
gi 896153305  79 SLAVAKFRVPDEGKK 93
Cdd:PRK12599  77 TVAIAKYLVGRGGVL 91
PRK12657 PRK12657
putative monovalent cation/H+ antiporter subunit F; Reviewed
 17-85 7.63e-06

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 183657  Cd Length: 100  Bit Score: 42.06  E-value: 7.63e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896153305  17 YFIAVMITLGHMIAGPNSLDRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAKF 85
Cdd:PRK12657  17 FGIALIICLFRLIKGPTTADRVVTFDTTSAVVMSIVGVLSVLMGTVSFLDSIMLIAIISFVSSVSISRF 85
PRK06161 PRK06161
putative monovalent cation/H+ antiporter subunit F; Reviewed
 19-85 9.51e-06

putative monovalent cation/H+ antiporter subunit F; Reviewed


Pssm-ID: 180435  Cd Length: 89  Bit Score: 41.37  E-value: 9.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896153305  19 IAVMITLGHMIAGPNSLDRLVALESM--TAMLqgMLAAFMAWsLDTSVVYPM-LIVALLGFLSSLAVAKF 85
Cdd:PRK06161  15 LAMLLALWRLLRGPRAQDRILALDTLyiNAIL--LLLVFGIR-LGSTIYFEAaLLIALLGFVSTVALAKF 81
PRK12600 PRK12600
Na(+)/H(+) antiporter subunit F1;
6-85 1.19e-05

Na(+)/H(+) antiporter subunit F1;


Pssm-ID: 183617  Cd Length: 94  Bit Score: 41.07  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896153305   6 FNILLGVAAAGYFIAVMITLGHMIAGPNSLDRLVALESMTAMLQGMLAAFMAWSLDTSVVYPMLIVALLGFLSSLAVAKF 85
Cdd:PRK12600   2 FNIILSIALIIVAISMLLMLIRVIKGPTLADRVVALDAIGINLIAIIALFSILLDTKAYLEVILLIGILAFIGTAAFSKF 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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