NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|896155549|ref|WP_049172036|]
View 

MULTISPECIES: LutB/LldF family L-lactate oxidation iron-sulfur protein [Corynebacterium]

Protein Classification

lactate utilization protein B( domain architecture ID 11439020)

lactate utilization protein B (LutB) is an iron-sulfur cluster-binding protein involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source

Gene Ontology:  GO:0051539|GO:0046872

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LutB COG1139
L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and ...
 22-486 0e+00

L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and conversion];


:

Pssm-ID: 440754 [Multi-domain]  Cd Length: 465  Bit Score: 761.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  22 LRGTRGFTAAAHEELKNTRMRENVGHATRSIRQKRAHVVAEKNDWEQLRLAGSHIKRDVMARLPELLEQFEESVTNAGGH 101
Cdd:COG1139    3 KASSEDFKERAREALADEQLRKALDRATDTLRAKRAKAVAELPDWEALREAARAIKDHALANLDEYLEQFEANATANGGH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 102 VHWARDAAEANRIITDLVKETGEEKVVKIKSMATQEIGLNEALADAGITARETDLAELIVQLADDMPSHILVPAIHRNRE 181
Cdd:COG1139   83 VHWARDAEEANRIVLDIAREKGAKKVVKSKSMVTEEIGLNEALEAAGIEVVETDLGEYIVQLAGEPPSHIVMPAIHKNRE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 182 DIREIFLNGIPgvDPDLKANPADLAEASRKFLREQFMEAKVAISGANFGVAETGTVAVVESEGNGRMCLTLPETLISVMG 261
Cdd:COG1139  163 QIAELFHEKLG--TEPLTDDPEELTRAAREHLREKFLEADVGITGANFAVAETGTIVLVTNEGNARLCTTLPKVHIAVMG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 262 IEKLLPTFQDLEVFLQLLPRSSTGERMNPYTSLWTGTT---DGDGPKNFHIVLLDNGRSATLADPIGREALKCIRCSACL 338
Cdd:COG1139  241 IEKLVPTLEDLEVFLRLLPRSATGQRITTYTSLITGPRrpgEGDGPEEFHLVLLDNGRSAMLADPEFREALRCIRCGACL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 339 NICPVYEHVGGHAYGSVYPGPIGAILSPQLTGMDSYddpnASLPYASSLCGACFEVCPVRIDIPAALLELRHRKVTEHR- 417
Cdd:COG1139  321 NVCPVYRRVGGHAYGSVYPGPIGAVLTPLLHGLEKA----ADLPYASTLCGACTEVCPVKIPIPELLLELRERIVEEGLt 396

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896155549 418 PPVEGKLFATLGFIMGNQKLWNMSAKMASLARVLGLKDGEIHALPLFLSGWSDVRDTPVPPQKPFRSVW 486
Cdd:COG1139  397 PPAEKLAMKAWAWVMSNPKLYRLALRLARRALKLLPRGGGIRRLPGPLGGWTKGRDLPAPAKESFRDWW 465
 
Name Accession Description Interval E-value
LutB COG1139
L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and ...
 22-486 0e+00

L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and conversion];


Pssm-ID: 440754 [Multi-domain]  Cd Length: 465  Bit Score: 761.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  22 LRGTRGFTAAAHEELKNTRMRENVGHATRSIRQKRAHVVAEKNDWEQLRLAGSHIKRDVMARLPELLEQFEESVTNAGGH 101
Cdd:COG1139    3 KASSEDFKERAREALADEQLRKALDRATDTLRAKRAKAVAELPDWEALREAARAIKDHALANLDEYLEQFEANATANGGH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 102 VHWARDAAEANRIITDLVKETGEEKVVKIKSMATQEIGLNEALADAGITARETDLAELIVQLADDMPSHILVPAIHRNRE 181
Cdd:COG1139   83 VHWARDAEEANRIVLDIAREKGAKKVVKSKSMVTEEIGLNEALEAAGIEVVETDLGEYIVQLAGEPPSHIVMPAIHKNRE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 182 DIREIFLNGIPgvDPDLKANPADLAEASRKFLREQFMEAKVAISGANFGVAETGTVAVVESEGNGRMCLTLPETLISVMG 261
Cdd:COG1139  163 QIAELFHEKLG--TEPLTDDPEELTRAAREHLREKFLEADVGITGANFAVAETGTIVLVTNEGNARLCTTLPKVHIAVMG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 262 IEKLLPTFQDLEVFLQLLPRSSTGERMNPYTSLWTGTT---DGDGPKNFHIVLLDNGRSATLADPIGREALKCIRCSACL 338
Cdd:COG1139  241 IEKLVPTLEDLEVFLRLLPRSATGQRITTYTSLITGPRrpgEGDGPEEFHLVLLDNGRSAMLADPEFREALRCIRCGACL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 339 NICPVYEHVGGHAYGSVYPGPIGAILSPQLTGMDSYddpnASLPYASSLCGACFEVCPVRIDIPAALLELRHRKVTEHR- 417
Cdd:COG1139  321 NVCPVYRRVGGHAYGSVYPGPIGAVLTPLLHGLEKA----ADLPYASTLCGACTEVCPVKIPIPELLLELRERIVEEGLt 396

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896155549 418 PPVEGKLFATLGFIMGNQKLWNMSAKMASLARVLGLKDGEIHALPLFLSGWSDVRDTPVPPQKPFRSVW 486
Cdd:COG1139  397 PPAEKLAMKAWAWVMSNPKLYRLALRLARRALKLLPRGGGIRRLPGPLGGWTKGRDLPAPAKESFRDWW 465
TIGR00273 TIGR00273
iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding ...
 36-475 6.44e-157

iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4fe-4S iron-sulfur clusters. [Energy metabolism, Electron transport]


Pssm-ID: 129374 [Multi-domain]  Cd Length: 432  Bit Score: 453.56  E-value: 6.44e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549   36 LKNTRMRENVGHATRSIRQKRAHVVAEKNDWEQLRLAGSHIKRDVMARLPELLEQFEESVTNAGGHVHWARDAAEANRII 115
Cdd:TIGR00273   1 IKDGILREALRNAQERLRANRKLLVEELGYWEEWRELVKEIKLKVLENLDFYLDQLKENVTQRGGHVYYAKTAEEARKII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  116 TDLVKETGEEKVVKIKSMATQEIGLNEALADAGITARETDLAELIVQLADDMPSHILVPAIHRNREDIREIFLNGIPGVD 195
Cdd:TIGR00273  81 GKVAQEKNGKKVVKSKSMVSEEIGLNEVLEKIGIEVWETDLGELILQLDGDPPSHIVVPALHKNRQQIGEILKERLGYEG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  196 PDlkaNPADLAEASRKFLREQFMEAKVAISGANFGVAETGTVAVVESEGNGRMCLTLPETLISVMGIEKLLPTFQDLEVF 275
Cdd:TIGR00273 161 EE---SPEVLAREARKFMREKFLSADIGISGCNFAIAETGSIFLVENEGNGRLSTTLPKTHIAVMGIEKIVPTFDDELVL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  276 LQLLPRSSTGERMNPYTSLWTG---TTDGDGPKNFHIVLLDNGRSATLADPIgREALKCIRCSACLNICPVYEHVGGHAY 352
Cdd:TIGR00273 238 KSMLARSAVGTRLTAYINVLTGprqEGDVDGPEEFHLILLDNGRSNILATEF-REVLACIRCGACQNECPVYRHIGGHWY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  353 GSVYPGPIGAILSPQLTGMDSYDDpnasLPYASSLCGACFEVCPVRIDIPAALLELRHRKVTEHRPPVEGKlFATLGFIM 432
Cdd:TIGR00273 317 GSIYPGPIGAVWSPLLGGYTDYKH----LPYLSSLCGACREVCPVKIPLPELIREHRSDKVEKGRHSGMEK-LAMKMFAK 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 896155549  433 GNQK--LWNMSAKMASLArvlgLKDGEIHALPLFLSGWSDVRDTP 475
Cdd:TIGR00273 392 MASDgaLWKFGLKMAQFF----SPLGKLLAPIGPVKEWASVRDLP 432
LUD_dom pfam02589
LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and ...
 88-312 6.44e-49

LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate


Pssm-ID: 426855  Cd Length: 188  Bit Score: 166.63  E-value: 6.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549   88 LEQFEESVTNAGGHVHWARDAAEANRIITDLVKETGeekvvkiksmatqeiglnealadAGITARETDLAELIvqladdm 167
Cdd:pfam02589   1 LEEFKENLEANGAEVYYAKTAEEALEYILELIKEGG-----------------------VVSEGGSTDLGELG------- 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  168 pshiLVPAIHRNREDIREIFlngipgvdpdlkanPADLAEASRKFLREQFMEAKVAISGANFGVAETGTVAVVESEGNGR 247
Cdd:pfam02589  51 ----LAPALHSGRYEVLDLF--------------EEKLTAEAREELREKALTADVGITGANFAIAETGTLVLVDGEGNRR 112

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 896155549  248 MCLTLPETLISVMGIEKLLPTFQDLEVFLQLLPRSSTGERMNPYTSLWTG---TTDGD--------GPKNFHIVLL 312
Cdd:pfam02589 113 LLSFLPKVHIAVVGINKIVPDLEDAVKRLRLAPRNATRQKLTPYITFISGpsrTADIElvlvvgvhGPGELHVILV 188
PRK06259 PRK06259
succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional
 331-411 4.96e-07

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional


Pssm-ID: 235756 [Multi-domain]  Cd Length: 486  Bit Score: 52.32  E-value: 4.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 331 CIRCSACLNICPVYEHvgghaygSVYPGPIgaiLSPQLT--GMDSYDDPNASLP------YASSLCGACFEVCPVRIDIP 402
Cdd:PRK06259 135 CIECLSCVSTCPARKV-------SDYPGPT---FMRQLArfAFDPRDEGDREKEafdeglYNCTTCGKCVEVCPKEIDIP 204

                         90
                 ....*....|
gi 896155549 403 AALLE-LRHR 411
Cdd:PRK06259 205 GKAIEkLRAL 214
 
Name Accession Description Interval E-value
LutB COG1139
L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and ...
 22-486 0e+00

L-lactate utilization protein LutB, contains a ferredoxin-type domain [Energy production and conversion];


Pssm-ID: 440754 [Multi-domain]  Cd Length: 465  Bit Score: 761.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  22 LRGTRGFTAAAHEELKNTRMRENVGHATRSIRQKRAHVVAEKNDWEQLRLAGSHIKRDVMARLPELLEQFEESVTNAGGH 101
Cdd:COG1139    3 KASSEDFKERAREALADEQLRKALDRATDTLRAKRAKAVAELPDWEALREAARAIKDHALANLDEYLEQFEANATANGGH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 102 VHWARDAAEANRIITDLVKETGEEKVVKIKSMATQEIGLNEALADAGITARETDLAELIVQLADDMPSHILVPAIHRNRE 181
Cdd:COG1139   83 VHWARDAEEANRIVLDIAREKGAKKVVKSKSMVTEEIGLNEALEAAGIEVVETDLGEYIVQLAGEPPSHIVMPAIHKNRE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 182 DIREIFLNGIPgvDPDLKANPADLAEASRKFLREQFMEAKVAISGANFGVAETGTVAVVESEGNGRMCLTLPETLISVMG 261
Cdd:COG1139  163 QIAELFHEKLG--TEPLTDDPEELTRAAREHLREKFLEADVGITGANFAVAETGTIVLVTNEGNARLCTTLPKVHIAVMG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 262 IEKLLPTFQDLEVFLQLLPRSSTGERMNPYTSLWTGTT---DGDGPKNFHIVLLDNGRSATLADPIGREALKCIRCSACL 338
Cdd:COG1139  241 IEKLVPTLEDLEVFLRLLPRSATGQRITTYTSLITGPRrpgEGDGPEEFHLVLLDNGRSAMLADPEFREALRCIRCGACL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 339 NICPVYEHVGGHAYGSVYPGPIGAILSPQLTGMDSYddpnASLPYASSLCGACFEVCPVRIDIPAALLELRHRKVTEHR- 417
Cdd:COG1139  321 NVCPVYRRVGGHAYGSVYPGPIGAVLTPLLHGLEKA----ADLPYASTLCGACTEVCPVKIPIPELLLELRERIVEEGLt 396

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896155549 418 PPVEGKLFATLGFIMGNQKLWNMSAKMASLARVLGLKDGEIHALPLFLSGWSDVRDTPVPPQKPFRSVW 486
Cdd:COG1139  397 PPAEKLAMKAWAWVMSNPKLYRLALRLARRALKLLPRGGGIRRLPGPLGGWTKGRDLPAPAKESFRDWW 465
TIGR00273 TIGR00273
iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding ...
 36-475 6.44e-157

iron-sulfur cluster-binding protein; Members of this family have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4fe-4S iron-sulfur clusters. [Energy metabolism, Electron transport]


Pssm-ID: 129374 [Multi-domain]  Cd Length: 432  Bit Score: 453.56  E-value: 6.44e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549   36 LKNTRMRENVGHATRSIRQKRAHVVAEKNDWEQLRLAGSHIKRDVMARLPELLEQFEESVTNAGGHVHWARDAAEANRII 115
Cdd:TIGR00273   1 IKDGILREALRNAQERLRANRKLLVEELGYWEEWRELVKEIKLKVLENLDFYLDQLKENVTQRGGHVYYAKTAEEARKII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  116 TDLVKETGEEKVVKIKSMATQEIGLNEALADAGITARETDLAELIVQLADDMPSHILVPAIHRNREDIREIFLNGIPGVD 195
Cdd:TIGR00273  81 GKVAQEKNGKKVVKSKSMVSEEIGLNEVLEKIGIEVWETDLGELILQLDGDPPSHIVVPALHKNRQQIGEILKERLGYEG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  196 PDlkaNPADLAEASRKFLREQFMEAKVAISGANFGVAETGTVAVVESEGNGRMCLTLPETLISVMGIEKLLPTFQDLEVF 275
Cdd:TIGR00273 161 EE---SPEVLAREARKFMREKFLSADIGISGCNFAIAETGSIFLVENEGNGRLSTTLPKTHIAVMGIEKIVPTFDDELVL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  276 LQLLPRSSTGERMNPYTSLWTG---TTDGDGPKNFHIVLLDNGRSATLADPIgREALKCIRCSACLNICPVYEHVGGHAY 352
Cdd:TIGR00273 238 KSMLARSAVGTRLTAYINVLTGprqEGDVDGPEEFHLILLDNGRSNILATEF-REVLACIRCGACQNECPVYRHIGGHWY 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  353 GSVYPGPIGAILSPQLTGMDSYDDpnasLPYASSLCGACFEVCPVRIDIPAALLELRHRKVTEHRPPVEGKlFATLGFIM 432
Cdd:TIGR00273 317 GSIYPGPIGAVWSPLLGGYTDYKH----LPYLSSLCGACREVCPVKIPLPELIREHRSDKVEKGRHSGMEK-LAMKMFAK 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 896155549  433 GNQK--LWNMSAKMASLArvlgLKDGEIHALPLFLSGWSDVRDTP 475
Cdd:TIGR00273 392 MASDgaLWKFGLKMAQFF----SPLGKLLAPIGPVKEWASVRDLP 432
LUD_dom pfam02589
LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and ...
 88-312 6.44e-49

LUD domain; This entry represents a domain found in lactate utilization proteins B (LutB) and C (LutC), as well as several uncharacterized proteins. LutB and LutC are encoded by th conserved LutABC operon in bacteria. They are involved in lactate utilization and is implicated in the oxidative conversion of L-lactate into pyruvate


Pssm-ID: 426855  Cd Length: 188  Bit Score: 166.63  E-value: 6.44e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549   88 LEQFEESVTNAGGHVHWARDAAEANRIITDLVKETGeekvvkiksmatqeiglnealadAGITARETDLAELIvqladdm 167
Cdd:pfam02589   1 LEEFKENLEANGAEVYYAKTAEEALEYILELIKEGG-----------------------VVSEGGSTDLGELG------- 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  168 pshiLVPAIHRNREDIREIFlngipgvdpdlkanPADLAEASRKFLREQFMEAKVAISGANFGVAETGTVAVVESEGNGR 247
Cdd:pfam02589  51 ----LAPALHSGRYEVLDLF--------------EEKLTAEAREELREKALTADVGITGANFAIAETGTLVLVDGEGNRR 112

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 896155549  248 MCLTLPETLISVMGIEKLLPTFQDLEVFLQLLPRSSTGERMNPYTSLWTG---TTDGD--------GPKNFHIVLL 312
Cdd:pfam02589 113 LLSFLPKVHIAVVGINKIVPDLEDAVKRLRLAPRNATRQKLTPYITFISGpsrTADIElvlvvgvhGPGELHVILV 188
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 330-399 6.40e-14

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 66.57  E-value: 6.40e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  330 KCIRCSACLNICPVYEHVGGHAYGSVYPGPIGAIlspqltGMDSYDDPNASLPYASSLCGACFEVCPVRI 399
Cdd:pfam13183   1 RCIRCGACLAACPVYLVTGGRFPGDPRGGAAALL------GRLEALEGLAEGLWLCTLCGACTEVCPVGI 64
LutC COG1556
L-lactate utilization protein LutC, contains LUD domain [Energy production and conversion];
85-313 1.80e-12

L-lactate utilization protein LutC, contains LUD domain [Energy production and conversion];


Pssm-ID: 441165  Cd Length: 206  Bit Score: 66.42  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  85 PELLEQFEESVTNAGGHVHWARDAAEANRIITDLVKETGeekvvkIKSMATQEIGLNEALADAGITARETDlaelivqla 164
Cdd:COG1556   36 DDLVELFVERLEAVGGEVVRVTTEAELPAALAELLAEAG------LKRIVVPEPGLPAALQLAWDPLEELE--------- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 165 ddmpshilvpaihrnredireiflngipgvdpdlkaNPADLAEAsrkflreqfmeaKVAISGANFGVAETGTVAVVESEG 244
Cdd:COG1556  101 ------------------------------------DPAALEDA------------DVGITGAEFGIAETGTIVLDSGPD 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 245 NGRMCLTLPETLISVMGIEKLLPTFQDLevfLQLLPRSstgERMNPYTSLWTG---TTD--GD------GPKNFHIVLLD 313
Cdd:COG1556  133 QGRALSLLPEHHIVVVPASQIVPTMHEA---YARLREK---AGLPRNITFISGpskTADieQTlvlgahGPRRLHVILVE 206
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 320-428 3.61e-10

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 62.02  E-value: 3.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 320 LADPIGREALKCIRCSACLNICPVYEHVGGHAYGSVY-PGPIGAILSPQLTgMDSYDDPNASLpYASSLCGACFEVCPVR 398
Cdd:COG0247   69 PWKELLDALDACVGCGFCRAMCPSYKATGDEKDSPRGrINLLREVLEGELP-LDLSEEVYEVL-DLCLTCKACETACPSG 146

                         90       100       110
                 ....*....|....*....|....*....|
gi 896155549 399 IDIPAALLELRHRKVTEHRPPVEGKLFATL 428
Cdd:COG0247  147 VDIADLIAEARAQLVERGGRPLRDRLLRTF 176
PRK06259 PRK06259
succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional
 331-411 4.96e-07

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional


Pssm-ID: 235756 [Multi-domain]  Cd Length: 486  Bit Score: 52.32  E-value: 4.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 331 CIRCSACLNICPVYEHvgghaygSVYPGPIgaiLSPQLT--GMDSYDDPNASLP------YASSLCGACFEVCPVRIDIP 402
Cdd:PRK06259 135 CIECLSCVSTCPARKV-------SDYPGPT---FMRQLArfAFDPRDEGDREKEafdeglYNCTTCGKCVEVCPKEIDIP 204

                         90
                 ....*....|
gi 896155549 403 AALLE-LRHR 411
Cdd:PRK06259 205 GKAIEkLRAL 214
LutB_C pfam11870
Lactate utilization protein B, C-terminal; This domain is functionally uncharacterized. This ...
 408-486 1.24e-06

Lactate utilization protein B, C-terminal; This domain is functionally uncharacterized. This domain is found at the C-terminal of a family of 4Fe-4S, iron-sulphur cluster binding proteins, including Lactate utilization protein B (LutB). These proteins have a perfect 4Fe-4S binding motif C-x(2)-C-x(2)-C-x(3)-CP followed by either a perfect or imperfect (the first Cys replaced by Ser) second copy. Members probably bind two 4Fe-4S iron-sulphur clusters. This domain is found in LutB proteins in association with the LUD domain (pfam02589) and usually Fer4_8 (pfam13183). The LutABC operon is involved in lactate-utilization and is essential.


Pssm-ID: 432147 [Multi-domain]  Cd Length: 86  Bit Score: 46.51  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549  408 LRHRKVTEHRPPVEGK----------LFATLGFIMGNQKLWNMSAKMASLARvlglkdgeiHALPLFLSGWSDVRDTPVP 477
Cdd:pfam11870   2 LRHEPVGQGPGVIKGQgakrsaaerlAWKGFALAASSPGLYRLGTWLATRFR---------GLLPSKLKAWTRVRTFPKP 72


                  ....*....
gi 896155549  478 PQKPFRSVW 486
Cdd:pfam11870  73 AARSLHDLA 81
glpC PRK11168
anaerobic glycerol-3-phosphate dehydrogenase subunit C;
331-454 8.10e-05

anaerobic glycerol-3-phosphate dehydrogenase subunit C;


Pssm-ID: 236869 [Multi-domain]  Cd Length: 396  Bit Score: 44.86  E-value: 8.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 331 CIRCSACLNICPVYEhvgghaYGSVYPGP--IGailsPQ-----LTGMDSYDDpnaSLPYASSlCGACFEVCP--VRI-D 400
Cdd:PRK11168   9 CIKCTVCTTACPVAR------VNPLYPGPkqAG----PDgerlrLKDGALYDE---SLKYCSN-CKRCEVACPsgVKIgD 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 896155549 401 IPAallELRHRKVTEHRPPVEGKLFATLGfIMGnqklwNMSAKMASLAR-VLGLK 454
Cdd:PRK11168  75 IIQ---RARAKYVTERGPPLRDRILSHTD-LMG-----SLATPFAPLVNaATGLK 120
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
330-397 2.79e-04

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 39.33  E-value: 2.79e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896155549 330 KCIRCSACLNICPVyehvgghaygsvypgpiGAIlspqltgmdSYDDPNASLPYAS-SLCGACFEVCPV 397
Cdd:COG2768   12 KCIGCGACVKVCPV-----------------GAI---------SIEDGKAVIDPEKcIGCGACIEVCPV 54
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 306-397 2.85e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 39.64  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 306 NFHIVLLDNGRSATladPIGREALKCIRCSACLNICPVyehvgghayGSVYPGPIGAILSPQL-TGmdsyddpnaslpya 384
Cdd:COG4231    2 NITVKILDNRTTAM---RYVIDEDKCTGCGACVKVCPA---------DAIEEGDGKAVIDPDLcIG-------------- 55

                         90
                 ....*....|...
gi 896155549 385 sslCGACFEVCPV 397
Cdd:COG4231   56 ---CGSCVQVCPV 65
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 324-396 2.90e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 38.77  E-value: 2.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 896155549  324 IGREALKCIRCSACLNICPVYEHVGGHAYGSVYPGPIgAILSPQLTGmdsyddpnaslpyasslCGACFEVCP 396
Cdd:pfam13237   2 VVIDPDKCIGCGRCTAACPAGLTRVGAIVERLEGEAV-RIGVWKCIG-----------------CGACVEACP 56
NapF COG1145
Ferredoxin [Energy production and conversion];
330-407 5.90e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 41.63  E-value: 5.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 330 KCIRCSACLNICPVyehvgghaygsvypgpiGAIlspqltgmdSYDDPNASLPYASSLC---GACFEVCPVR-IDIPAAL 405
Cdd:COG1145  183 KCIGCGLCVKVCPT-----------------GAI---------RLKDGKPQIVVDPDKCigcGACVKVCPVGaISLEPKE 236


                 ..
gi 896155549 406 LE 407
Cdd:COG1145  237 IE 238
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 330-400 1.37e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 37.06  E-value: 1.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 896155549  330 KCIRCSACLNICPVYEHVGGHAYgsvypGPIGAILSPQLTGMDSYDdpnasLPYASSLCGACFEVCPVRID 400
Cdd:pfam13534   1 RCIQCGCCVDECPRYLLNGDEPK-----KLMRAAYLGDLEELQANK-----VANLCSECGLCEYACPMGLD 61
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
331-396 1.38e-03

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 37.08  E-value: 1.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 896155549  331 CIRCSACLNICPVyehvgGHAYGSVYPGPIGAILSPQLTGMDSY-DDPNASLPY-ASSLCGACFEVCP 396
Cdd:pfam13484   1 CGSCGKCIDACPT-----GAIVGPEGVLDARRCISYLTIEKKGLiPDELRCLLGnRCYGCDICQDVCP 63
Fer4_9 pfam13187
4Fe-4S dicluster domain;
330-396 1.44e-03

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 36.76  E-value: 1.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896155549  330 KCIRCSACLNICPvyehvgghaYGSVYPGPIGAILSPQLTGMDSYDdpnaslpyasslCGACFEVCP 396
Cdd:pfam13187   1 KCTGCGACVAACP---------AGAIVPDLVGQTIRGDIAGLACIG------------CGACVDACP 46
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
 327-416 2.49e-03

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 39.73  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896155549 327 EALKCIRCSACLNICPVYehvgghAYGSVYPGPiGAILSPQLTGMDSYDDPNAS-LPYAS--------SLCGACFEVCPV 397
Cdd:COG0479  140 DLAECILCGACVAACPNV------WANPDFLGP-AALAQAYRFALDPRDEETEErLEALEdeegvwrcTTCGNCTEVCPK 212

                         90
                 ....*....|....*....
gi 896155549 398 RIDIPAALLELRhRKVTEH 416
Cdd:COG0479  213 GIPPTKAIAKLK-REALKR 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH