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Conserved domains on  [gi|896156227|ref|WP_049172688|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Corynebacterium]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 14302098)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-123 2.35e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.85  E-value: 2.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   1 MRTSKRTAILDTIVEIIETSGFSEVTYENVATQCGMSKSGLIYHFPSREDMIRSVHEHMAQLWEEELIEAaggpAEEVSP 80
Cdd:COG1309    3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEA----LAAEDP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 896156227  81 ANRLRANLQVSLDTATRAELLMSI---DSAAEPELREIWTRLLRRW 123
Cdd:COG1309   79 RERLRALLRAYLEFLAENPALARLllaEAAELPELRAALRALLRRL 124
TetR_C_28 pfam17937
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 83-176 1.53e-09

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.


:

Pssm-ID: 436157  Cd Length: 97  Bit Score: 52.67  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   83 RLRANLQVSLDTATRAELL--MSIDSAAEPELREIWTRLLRRWNPPAEKIATDEEAcmAYVVQMISDGLWANDYLNGNQL 160
Cdd:pfam17937   3 WLRAYLRATFDDAAERRLLaaLLAALAEDPELLEPWREWYRRWLERLEADGLDPVL--ATIVRLAADGLWLAELLGLPPL 80

                          90
                  ....*....|....*.
gi 896156227  161 TKAQRKAIAEAAAKLI 176
Cdd:pfam17937  81 DPEEREALLDRLLALT 96
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-123 2.35e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.85  E-value: 2.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   1 MRTSKRTAILDTIVEIIETSGFSEVTYENVATQCGMSKSGLIYHFPSREDMIRSVHEHMAQLWEEELIEAaggpAEEVSP 80
Cdd:COG1309    3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEA----LAAEDP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 896156227  81 ANRLRANLQVSLDTATRAELLMSI---DSAAEPELREIWTRLLRRW 123
Cdd:COG1309   79 RERLRALLRAYLEFLAENPALARLllaEAAELPELRAALRALLRRL 124
TetR_C_28 pfam17937
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 83-176 1.53e-09

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.


Pssm-ID: 436157  Cd Length: 97  Bit Score: 52.67  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   83 RLRANLQVSLDTATRAELL--MSIDSAAEPELREIWTRLLRRWNPPAEKIATDEEAcmAYVVQMISDGLWANDYLNGNQL 160
Cdd:pfam17937   3 WLRAYLRATFDDAAERRLLaaLLAALAEDPELLEPWREWYRRWLERLEADGLDPVL--ATIVRLAADGLWLAELLGLPPL 80

                          90
                  ....*....|....*.
gi 896156227  161 TKAQRKAIAEAAAKLI 176
Cdd:pfam17937  81 DPEEREALLDRLLALT 96
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 3-93 1.00e-06

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 46.85  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   3 TSKRTAILDTIVEIIETSGFSEVTYENVATQCGMSKSGLIYHFPSREDMIRSVHEHMAQLWEEELIEAAGGPAEEVSPAN 82
Cdd:PRK15008  17 SAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFREDFAPLAAIKE 96

                         90
                 ....*....|.
gi 896156227  83 RLRANLQVSLD 93
Cdd:PRK15008  97 YIRLKLEVSRD 107
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
9-55 2.67e-06

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 42.39  E-value: 2.67e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 896156227    9 ILDTIVEIIETSGFSEVTYENVATQCGMSKSGLIYHFPSREDMIRSV 55
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
1-123 2.35e-14

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 66.85  E-value: 2.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   1 MRTSKRTAILDTIVEIIETSGFSEVTYENVATQCGMSKSGLIYHFPSREDMIRSVHEHMAQLWEEELIEAaggpAEEVSP 80
Cdd:COG1309    3 RREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEA----LAAEDP 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 896156227  81 ANRLRANLQVSLDTATRAELLMSI---DSAAEPELREIWTRLLRRW 123
Cdd:COG1309   79 RERLRALLRAYLEFLAENPALARLllaEAAELPELRAALRALLRRL 124
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
6-123 1.16e-12

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 63.03  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   6 RTAILDTIVEIIETSGFSEVTYENVATQCGMSKSGLIYHFPSREDMIRSVHEHMAQLWEEELIEAAGGPAEEVSPANRLR 85
Cdd:COG3226   10 RERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEALA 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 896156227  86 ANLQVSL---DTATRAELLMSIDSAAEPELREIWTRLLRRW 123
Cdd:COG3226   90 DLLAELLpadRDRLLARYELYLEALRDPELRALLRRWRDRL 130
TetR_C_28 pfam17937
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 83-176 1.53e-09

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in CgmR (C. glutamicum multidrug-responsive transcriptional repressor), previously called CGL2612 protein. CgmR (CGL2612) from Corynebacterium glutamicum is a multidrug-resistance-related transcription factor belonging to the TetR family. It regulates expression of the immediately upstream gene cgmA (cgl2611) by binding to the operator cgmO in the cgmA promoter. The cgmA gene encodes a permease belonging to the major facilitator superfamily, a protein family composed of bacterial multidrug exporters, and the pair of CgmR and CgmA confers multidrug resistance on C. glutamicum.


Pssm-ID: 436157  Cd Length: 97  Bit Score: 52.67  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   83 RLRANLQVSLDTATRAELL--MSIDSAAEPELREIWTRLLRRWNPPAEKIATDEEAcmAYVVQMISDGLWANDYLNGNQL 160
Cdd:pfam17937   3 WLRAYLRATFDDAAERRLLaaLLAALAEDPELLEPWREWYRRWLERLEADGLDPVL--ATIVRLAADGLWLAELLGLPPL 80

                          90
                  ....*....|....*.
gi 896156227  161 TKAQRKAIAEAAAKLI 176
Cdd:pfam17937  81 DPEEREALLDRLLALT 96
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 3-93 1.00e-06

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 46.85  E-value: 1.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896156227   3 TSKRTAILDTIVEIIETSGFSEVTYENVATQCGMSKSGLIYHFPSREDMIRSVHEHMAQLWEEELIEAAGGPAEEVSPAN 82
Cdd:PRK15008  17 SAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLKAFREDFAPLAAIKE 96

                         90
                 ....*....|.
gi 896156227  83 RLRANLQVSLD 93
Cdd:PRK15008  97 YIRLKLEVSRD 107
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
9-55 2.67e-06

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 42.39  E-value: 2.67e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 896156227    9 ILDTIVEIIETSGFSEVTYENVATQCGMSKSGLIYHFPSREDMIRSV 55
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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