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Conserved domains on  [gi|896409105|ref|WP_049346007|]
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MULTISPECIES: polyprenyltransferase [Rothia]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MpPF26 super family cl06629
M penetrans paralogue family 26; These proteins include those ascribed to M penetrans ...
110-178 1.00e-06

M penetrans paralogue family 26; These proteins include those ascribed to M penetrans paralogue family 26 in. This family contains a region of transmembrane helices.


The actual alignment was detected with superfamily member NF040945:

Pssm-ID: 471468  Cd Length: 99  Bit Score: 45.55  E-value: 1.00e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896409105 110 AQTSTVLGIISLACIvtlswWLFGLPSLILGVIGIFKANEAERF----------GAAASAGRILNWISVVIGGMFLVLF 178
Cdd:NF040945   2 ATLVLVLGILSIVCC-----CCYGILGLILGIIALVLANKAEKLyqenpelysnYSNVKTGKILAIIGLVLNVLYLLYT 75
 
Name Accession Description Interval E-value
CCC_membrane NF040945
CCC motif membrane protein; Members of this family average about 150 amino acids in length and ...
110-178 1.00e-06

CCC motif membrane protein; Members of this family average about 150 amino acids in length and are hydrophobic, with several probable transmembrane alpha helices. A notable feature is a Cys-rich cluster, often CCC, starting at about position 22. Members of both this family and NF040944 previously were both included in Pfam model PF07666. But while both families are hydrophobic, they appear not to be truly homologous. NF040944 identifies members of a paralogous family in Mycoplasma penetrans that includes protein MYPE2350, and consequently some members of this family have carried names suggesting (improperly, we think) a relationship to that family.


Pssm-ID: 468876  Cd Length: 99  Bit Score: 45.55  E-value: 1.00e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896409105 110 AQTSTVLGIISLACIvtlswWLFGLPSLILGVIGIFKANEAERF----------GAAASAGRILNWISVVIGGMFLVLF 178
Cdd:NF040945   2 ATLVLVLGILSIVCC-----CCYGILGLILGIIALVLANKAEKLyqenpelysnYSNVKTGKILAIIGLVLNVLYLLYT 75
 
Name Accession Description Interval E-value
CCC_membrane NF040945
CCC motif membrane protein; Members of this family average about 150 amino acids in length and ...
110-178 1.00e-06

CCC motif membrane protein; Members of this family average about 150 amino acids in length and are hydrophobic, with several probable transmembrane alpha helices. A notable feature is a Cys-rich cluster, often CCC, starting at about position 22. Members of both this family and NF040944 previously were both included in Pfam model PF07666. But while both families are hydrophobic, they appear not to be truly homologous. NF040944 identifies members of a paralogous family in Mycoplasma penetrans that includes protein MYPE2350, and consequently some members of this family have carried names suggesting (improperly, we think) a relationship to that family.


Pssm-ID: 468876  Cd Length: 99  Bit Score: 45.55  E-value: 1.00e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896409105 110 AQTSTVLGIISLACIvtlswWLFGLPSLILGVIGIFKANEAERF----------GAAASAGRILNWISVVIGGMFLVLF 178
Cdd:NF040945   2 ATLVLVLGILSIVCC-----CCYGILGLILGIIALVLANKAEKLyqenpelysnYSNVKTGKILAIIGLVLNVLYLLYT 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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