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Conserved domains on  [gi|896525537|ref|WP_049429315|]
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MULTISPECIES: bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [Stenotrophomonas]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 3-214 4.25e-94

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PRK05718:

Pssm-ID: 473867  Cd Length: 212  Bit Score: 273.65  E-value: 4.25e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   3 IEQHQVKAAELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQM 82
Cdd:PRK05718   1 MKNWKTSIEEILRAGPVVPVIVINKLEDAVPLAKALVAGGLPVLEVTLRTPAALEAIRLIAKEVPEALIGAGTVLNPEQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  83 QQSIDAGADFLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCP 162
Cdd:PRK05718  81 AQAIEAGAQFIVSPGLTPPLLKAAQEGPIPLIPGVSTPSELMLGMELGLRTFKFFPAEASGGVKMLKALAGPFPDVRFCP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 896525537 163 TGGITENTAAEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRASAADAAKIIK 214
Cdd:PRK05718 161 TGGISPANYRDYLALPNVLCIGGSWMVPKDAIENGDWDRITRLAREAVALAK 212
 
Name Accession Description Interval E-value
PRK05718 PRK05718
keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional
 3-214 4.25e-94

keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional


Pssm-ID: 235577  Cd Length: 212  Bit Score: 273.65  E-value: 4.25e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   3 IEQHQVKAAELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQM 82
Cdd:PRK05718   1 MKNWKTSIEEILRAGPVVPVIVINKLEDAVPLAKALVAGGLPVLEVTLRTPAALEAIRLIAKEVPEALIGAGTVLNPEQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  83 QQSIDAGADFLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCP 162
Cdd:PRK05718  81 AQAIEAGAQFIVSPGLTPPLLKAAQEGPIPLIPGVSTPSELMLGMELGLRTFKFFPAEASGGVKMLKALAGPFPDVRFCP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 896525537 163 TGGITENTAAEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRASAADAAKIIK 214
Cdd:PRK05718 161 TGGISPANYRDYLALPNVLCIGGSWMVPKDAIENGDWDRITRLAREAVALAK 212
eda TIGR01182
Entner-Doudoroff aldolase; 2-deydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) is an ...
 12-213 8.33e-79

Entner-Doudoroff aldolase; 2-deydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) is an enzyme of the Entner-Doudoroff pathway. This aldolase has another function, 4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) shown experimentally in Escherichia coli and Pseudomonas putida [Amino acid biosynthesis, Glutamate family, Energy metabolism, Entner-Doudoroff]


Pssm-ID: 273490  Cd Length: 204  Bit Score: 234.90  E-value: 8.33e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   12 ELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQMQQSIDAGAD 91
Cdd:TIGR01182   3 ELLREAKIVPVIRIDDVDDALPLAKALIEGGLRVLEVTLRTPVALDAIRLLRKEVPDALIGAGTVLNPEQLRQAVAAGAQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   92 FLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCPTGGITENTA 171
Cdd:TIGR01182  83 FIVSPGLTPELAKHAQDHGIPIIPGVATPSEIMLALELGITALKLFPAEVSGGVKMLKALAGPFPQVRFCPTGGINLANA 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 896525537  172 AEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRASAADAAKII 213
Cdd:TIGR01182 163 RDYLALPNVACGGGSWLVPKDLIAAGDWDEITRLAREALEII 204
Eda COG0800
2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; ...
 12-218 1.22e-74

2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; 2-keto-3-deoxy-6-phosphogluconate aldolase is part of the Pathway/BioSystem: Entner-Doudoroff pathway


Pssm-ID: 440563  Cd Length: 213  Bit Score: 224.58  E-value: 1.22e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  12 ELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKREL-PDVVVGAGTVLTVEQMQQSIDAGA 90
Cdd:COG0800    7 ELLAAAPVVPVLRGDDPEDAVPLAEALVAGGIRAIEVTLRTPAALEAIRALAKEVgPDALVGAGTVLTPEQARAAIAAGA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  91 DFLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVgGLAMIKGLAGPVADLKLCPTGGITENT 170
Cdd:COG0800   87 RFIVSPGLDPEVIKAANRAGLPVLPGVATPTEIMAALEAGADAVKLFPAEAL-GPAYLKALKGPLPDVPFMPTGGVSPDN 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 896525537 171 AAEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRASAADAAKIIKRVRG 218
Cdd:COG0800  166 AADYLAAGAVAVGGGSWLVPKGAIAAGDWAAITERAREAVAAVRAARA 213
KDPG_aldolase cd00452
KDPG and KHG aldolase; KDPG and KHG aldolase. This family belongs to the class I adolases ...
 14-204 1.86e-62

KDPG and KHG aldolase; KDPG and KHG aldolase. This family belongs to the class I adolases whose reaction mechanism involves Schiff base formation between a substrate carbonyl and lysine residue in the active site. 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase, is best known for its role in the Entner-Doudoroff pathway of bacteria, where it catalyzes the reversible cleavage of KDPG to pyruvate and glyceraldehyde-3-phosphate. 2-keto-4-hydroxyglutarate (KHG) aldolase, which has enzymatic specificity toward glyoxylate, forming KHG in the presence of pyruvate, and is capable of regulating glyoxylate levels in the glyoxylate bypass, an alternate pathway when bacteria are grown on acetate carbon sources.


Pssm-ID: 188632  Cd Length: 190  Bit Score: 192.73  E-value: 1.86e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  14 LHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQMQQSIDAGADFL 93
Cdd:cd00452    1 LKAQPLVAVLRGDDAEDALALAEALIEGGIRAIEITLRTPGALEAIRALRKEFPEALIGAGTVLTPEQADAAIAAGAQFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  94 VTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVgGLAMIKGLAGPVADLKLCPTGGITENTAAE 173
Cdd:cd00452   81 VSPGLDPEVVKAANRAGIPLLPGVATPTEIMQALELGADIVKLFPAEAV-GPAYIKALKGPFPQVRFMPTGGVSLDNAAE 159

                        170       180       190
                 ....*....|....*....|....*....|.
gi 896525537 174 YLEQkNVVCIGGSWMVPGNWIADGEWDKVRA 204
Cdd:cd00452  160 WLAA-GVVAVGGGSLLPKDAVAAGDWAAITA 189
Aldolase pfam01081
KDPG and KHG aldolase; This family includes the following members: 4-hydroxy-2-oxoglutarate ...
 12-204 4.02e-55

KDPG and KHG aldolase; This family includes the following members: 4-hydroxy-2-oxoglutarate aldolase (KHG-aldolase) Phospho-2-dehydro-3-deoxygluconate aldolase (KDPG-aldolase)


Pssm-ID: 395858  Cd Length: 196  Bit Score: 174.20  E-value: 4.02e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   12 ELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQMQQSIDAGAD 91
Cdd:pfam01081   3 SILKEAKIVPVIVIKDKEDALPLAEALAAGGIRVLEVTLRTPCALDAIRLLRKNRPDALVGAGTVLNAQQLAEAAEAGAQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   92 FLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCPTGGITENTA 171
Cdd:pfam01081  83 FVVSPGLTADLLKHAVDVKIPLIPGVSTPSEIMLGLDLGLTRFKFFPAEASGGVPAIKALAGPFPQVRFCPTGGIHPANV 162

                         170       180       190
                  ....*....|....*....|....*....|...
gi 896525537  172 AEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRA 204
Cdd:pfam01081 163 RDYLALPNILCVGGSWLVPASLIQKGDWDRITA 195
 
Name Accession Description Interval E-value
PRK05718 PRK05718
keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional
 3-214 4.25e-94

keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional


Pssm-ID: 235577  Cd Length: 212  Bit Score: 273.65  E-value: 4.25e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   3 IEQHQVKAAELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQM 82
Cdd:PRK05718   1 MKNWKTSIEEILRAGPVVPVIVINKLEDAVPLAKALVAGGLPVLEVTLRTPAALEAIRLIAKEVPEALIGAGTVLNPEQL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  83 QQSIDAGADFLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCP 162
Cdd:PRK05718  81 AQAIEAGAQFIVSPGLTPPLLKAAQEGPIPLIPGVSTPSELMLGMELGLRTFKFFPAEASGGVKMLKALAGPFPDVRFCP 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 896525537 163 TGGITENTAAEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRASAADAAKIIK 214
Cdd:PRK05718 161 TGGISPANYRDYLALPNVLCIGGSWMVPKDAIENGDWDRITRLAREAVALAK 212
eda TIGR01182
Entner-Doudoroff aldolase; 2-deydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) is an ...
 12-213 8.33e-79

Entner-Doudoroff aldolase; 2-deydro-3-deoxyphosphogluconate aldolase (EC 4.1.2.14) is an enzyme of the Entner-Doudoroff pathway. This aldolase has another function, 4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) shown experimentally in Escherichia coli and Pseudomonas putida [Amino acid biosynthesis, Glutamate family, Energy metabolism, Entner-Doudoroff]


Pssm-ID: 273490  Cd Length: 204  Bit Score: 234.90  E-value: 8.33e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   12 ELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQMQQSIDAGAD 91
Cdd:TIGR01182   3 ELLREAKIVPVIRIDDVDDALPLAKALIEGGLRVLEVTLRTPVALDAIRLLRKEVPDALIGAGTVLNPEQLRQAVAAGAQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   92 FLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCPTGGITENTA 171
Cdd:TIGR01182  83 FIVSPGLTPELAKHAQDHGIPIIPGVATPSEIMLALELGITALKLFPAEVSGGVKMLKALAGPFPQVRFCPTGGINLANA 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 896525537  172 AEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRASAADAAKII 213
Cdd:TIGR01182 163 RDYLALPNVACGGGSWLVPKDLIAAGDWDEITRLAREALEII 204
Eda COG0800
2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; ...
 12-218 1.22e-74

2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; 2-keto-3-deoxy-6-phosphogluconate aldolase is part of the Pathway/BioSystem: Entner-Doudoroff pathway


Pssm-ID: 440563  Cd Length: 213  Bit Score: 224.58  E-value: 1.22e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  12 ELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKREL-PDVVVGAGTVLTVEQMQQSIDAGA 90
Cdd:COG0800    7 ELLAAAPVVPVLRGDDPEDAVPLAEALVAGGIRAIEVTLRTPAALEAIRALAKEVgPDALVGAGTVLTPEQARAAIAAGA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  91 DFLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVgGLAMIKGLAGPVADLKLCPTGGITENT 170
Cdd:COG0800   87 RFIVSPGLDPEVIKAANRAGLPVLPGVATPTEIMAALEAGADAVKLFPAEAL-GPAYLKALKGPLPDVPFMPTGGVSPDN 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 896525537 171 AAEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRASAADAAKIIKRVRG 218
Cdd:COG0800  166 AADYLAAGAVAVGGGSWLVPKGAIAAGDWAAITERAREAVAAVRAARA 213
KDPG_aldolase cd00452
KDPG and KHG aldolase; KDPG and KHG aldolase. This family belongs to the class I adolases ...
 14-204 1.86e-62

KDPG and KHG aldolase; KDPG and KHG aldolase. This family belongs to the class I adolases whose reaction mechanism involves Schiff base formation between a substrate carbonyl and lysine residue in the active site. 2-keto-3-deoxy-6-phosphogluconate (KDPG) aldolase, is best known for its role in the Entner-Doudoroff pathway of bacteria, where it catalyzes the reversible cleavage of KDPG to pyruvate and glyceraldehyde-3-phosphate. 2-keto-4-hydroxyglutarate (KHG) aldolase, which has enzymatic specificity toward glyoxylate, forming KHG in the presence of pyruvate, and is capable of regulating glyoxylate levels in the glyoxylate bypass, an alternate pathway when bacteria are grown on acetate carbon sources.


Pssm-ID: 188632  Cd Length: 190  Bit Score: 192.73  E-value: 1.86e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  14 LHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQMQQSIDAGADFL 93
Cdd:cd00452    1 LKAQPLVAVLRGDDAEDALALAEALIEGGIRAIEITLRTPGALEAIRALRKEFPEALIGAGTVLTPEQADAAIAAGAQFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  94 VTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVgGLAMIKGLAGPVADLKLCPTGGITENTAAE 173
Cdd:cd00452   81 VSPGLDPEVVKAANRAGIPLLPGVATPTEIMQALELGADIVKLFPAEAV-GPAYIKALKGPFPQVRFMPTGGVSLDNAAE 159

                        170       180       190
                 ....*....|....*....|....*....|.
gi 896525537 174 YLEQkNVVCIGGSWMVPGNWIADGEWDKVRA 204
Cdd:cd00452  160 WLAA-GVVAVGGGSLLPKDAVAAGDWAAITA 189
Aldolase pfam01081
KDPG and KHG aldolase; This family includes the following members: 4-hydroxy-2-oxoglutarate ...
 12-204 4.02e-55

KDPG and KHG aldolase; This family includes the following members: 4-hydroxy-2-oxoglutarate aldolase (KHG-aldolase) Phospho-2-dehydro-3-deoxygluconate aldolase (KDPG-aldolase)


Pssm-ID: 395858  Cd Length: 196  Bit Score: 174.20  E-value: 4.02e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   12 ELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQMQQSIDAGAD 91
Cdd:pfam01081   3 SILKEAKIVPVIVIKDKEDALPLAEALAAGGIRVLEVTLRTPCALDAIRLLRKNRPDALVGAGTVLNAQQLAEAAEAGAQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537   92 FLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCPTGGITENTA 171
Cdd:pfam01081  83 FVVSPGLTADLLKHAVDVKIPLIPGVSTPSEIMLGLDLGLTRFKFFPAEASGGVPAIKALAGPFPQVRFCPTGGIHPANV 162

                         170       180       190
                  ....*....|....*....|....*....|...
gi 896525537  172 AEYLEQKNVVCIGGSWMVPGNWIADGEWDKVRA 204
Cdd:pfam01081 163 RDYLALPNILCVGGSWLVPASLIQKGDWDRITA 195
PRK06015 PRK06015
2-dehydro-3-deoxy-phosphogluconate aldolase;
19-210 7.43e-53

2-dehydro-3-deoxy-phosphogluconate aldolase;


Pssm-ID: 168348  Cd Length: 201  Bit Score: 168.84  E-value: 7.43e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  19 ILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQMQQSIDAGADFLVTPGT 98
Cdd:PRK06015   6 VIPVLLIDDVEHAVPLARALAAGGLPAIEITLRTPAALDAIRAVAAEVEEAIVGAGTILNAKQFEDAAKAGSRFIVSPGT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  99 PPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCPTGGITENTAAEYLEQK 178
Cdd:PRK06015  86 TQELLAAANDSDVPLLPGAATPSEVMALREEGYTVLKFFPAEQAGGAAFLKALSSPLAGTFFCPTGGISLKNARDYLSLP 165

                        170       180       190
                 ....*....|....*....|....*....|..
gi 896525537 179 NVVCIGGSWMVPGNWIADGEWDKVRASAADAA 210
Cdd:PRK06015 166 NVVCVGGSWVAPKELVAAGDWAGITKLAAEAA 197
PRK07455 PRK07455
bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase;
12-176 1.33e-33

bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase;


Pssm-ID: 180985  Cd Length: 187  Bit Score: 118.99  E-value: 1.33e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  12 ELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPDVVVGAGTVLTVEQMQQSIDAGAD 91
Cdd:PRK07455   7 AQLQQHRAIAVIRAPDLELGLQMAEAVAAGGMRLIEITWNSDQPAELISQLREKLPECIIGTGTILTLEDLEEAIAAGAQ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  92 FLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVGGLAMIKGLAGPVADLKLCPTGGITENTA 171
Cdd:PRK07455  87 FCFTPHVDPELIEAAVAQDIPIIPGALTPTEIVTAWQAGASCVKVFPVQAVGGADYIKSLQGPLGHIPLIPTGGVTLENA 166


                 ....*
gi 896525537 172 AEYLE 176
Cdd:PRK07455 167 QAFIQ 171
PRK06552 PRK06552
keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional
 14-217 3.61e-27

keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase; Provisional


Pssm-ID: 180618  Cd Length: 213  Bit Score: 103.15  E-value: 3.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  14 LHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAMLK---RELPDVVVGAGTVLTVEQMQQSIDAGA 90
Cdd:PRK06552  10 LKANGVVAVVRGESKEEALKISLAVIKGGIKAIEVTYTNPFASEVIKELVelyKDDPEVLIGAGTVLDAVTARLAILAGA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  91 DFLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPATAVgGLAMIKGLAGPVADLKLCPTGGITENT 170
Cdd:PRK06552  90 QFIVSPSFNRETAKICNLYQIPYLPGCMTVTEIVTALEAGSEIVKLFPGSTL-GPSFIKAIKGPLPQVNVMVTGGVNLDN 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 896525537 171 AAEYLEQ-KNVVCIGGSWMVPGnwiADGEWDKVRASAADAAKIIKRVR 217
Cdd:PRK06552 169 VKDWFAAgADAVGIGGELNKLA---SQGDFDLITEKAKKYMSSLRKAK 213
PRK07114 PRK07114
bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase;
11-218 1.12e-25

bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase;


Pssm-ID: 235939  Cd Length: 222  Bit Score: 99.33  E-value: 1.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  11 AELLHAAGILPVVTIHTLDQARAVSAALLEGGLPAIELTLRTPVAMEALAML----KRELPDVVVGAGTVLTVEQMQQSI 86
Cdd:PRK07114   9 LTAMKATGMVPVFYHADVEVAKKVIKACYDGGARVFEFTNRGDFAHEVFAELvkyaAKELPGMILGVGSIVDAATAALYI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  87 DAGADFLVTPGTPPALADALAAAPLPVVPGAATPTELLSLYARGFRVCKLFPAtAVGGLAMIKGLAGPVADLKLCPTGGI 166
Cdd:PRK07114  89 QLGANFIVTPLFNPDIAKVCNRRKVPYSPGCGSLSEIGYAEELGCEIVKLFPG-SVYGPGFVKAIKGPMPWTKIMPTGGV 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 896525537 167 --TENTAAEYLEqKNVVCIG-GSWMVPGNWIADGEWDKVRASAADAAKIIKRVRG 218
Cdd:PRK07114 168 epTEENLKKWFG-AGVTCVGmGSKLIPKEALAAKDYAGIEQKVREALAIIKEVRK 221
PRK09140 PRK09140
2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed
 29-175 1.50e-20

2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed


Pssm-ID: 181670  Cd Length: 206  Bit Score: 85.26  E-value: 1.50e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896525537  29 DQARAVSAALLEGGLPAIELTLRTPVAMEALAMLKRELPD-VVVGAGTVLTVEQMQQSIDAGADFLVTPGTPPALADALA 107
Cdd:PRK09140  22 DEALAHVGALIEAGFRAIEIPLNSPDPFDSIAALVKALGDrALIGAGTVLSPEQVDRLADAGGRLIVTPNTDPEVIRRAV 101

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896525537 108 AAPLPVVPGAATPTELLSLYARGFRVCKLFPAtAVGGLAMIKGL-AGPVADLKLCPTGGITENTAAEYL 175
Cdd:PRK09140 102 ALGMVVMPGVATPTEAFAALRAGAQALKLFPA-SQLGPAGIKALrAVLPPDVPVFAVGGVTPENLAPYL 169
PTZ00314 PTZ00314
inosine-5'-monophosphate dehydrogenase; Provisional
 62-93 7.19e-03

inosine-5'-monophosphate dehydrogenase; Provisional


Pssm-ID: 240355 [Multi-domain]  Cd Length: 495  Bit Score: 36.87  E-value: 7.19e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 896525537  62 LKRELPDVVVGAGTVLTVEQMQQSIDAGADFL 93
Cdd:PTZ00314 276 LKSNYPHVDIIAGNVVTADQAKNLIDAGADGL 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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