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Conserved domains on  [gi|896573033|ref|WP_049468023|]
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MULTISPECIES: phosphoribosylaminoimidazolesuccinocarboxamide synthase [Stenotrophomonas]

Protein Classification

phosphoribosylaminoimidazolesuccinocarboxamide synthase( domain architecture ID 10793931)

phosphoribosylaminoimidazolesuccinocarboxamide synthase catalyzes the conversion of 5-aminoimidazole-4-carboxyribonucleotide (CAIR) to 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) in the de novo biosynthesis of purine nucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 2-308 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


:

Pssm-ID: 237571  Cd Length: 296  Bit Score: 545.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   2 PTTLLQSDLPGLPLRHRGKVRDVFDIPrerlpagtppGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAH 81
Cdd:PRK13961   1 MSTLMESDLPSLPLLGRGKVRDIYAVD----------DDRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAH 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  82 LMPNHLTGIDVASVLPEGvDPALYARRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPI 161
Cdd:PRK13961  71 IVPNHLTGIDVDDVVPAD-EADQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYQATGTVCGIKLPAGLVEASKLPEPI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 162 FTPSTKAAVGDHDENIDFDAMVKQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMLTPD 241
Cdd:PRK13961 150 FTPATKAELGDHDENISFEEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDEDGTLTLMDEVLTPD 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896573033 242 SSRYWPADEYEVGTSPPSYDKQFVRDYLETLDWGKTAPGPTIPAEIIERTRAKYAEALQRLAGISVD 308
Cdd:PRK13961 230 SSRFWPADSYQPGTSQPSFDKQFVRDWLETSGWDKTAPAPPLPADVIEKTRAKYREALERLTGKSLD 296
 
Name Accession Description Interval E-value
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 2-308 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 545.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   2 PTTLLQSDLPGLPLRHRGKVRDVFDIPrerlpagtppGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAH 81
Cdd:PRK13961   1 MSTLMESDLPSLPLLGRGKVRDIYAVD----------DDRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAH 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  82 LMPNHLTGIDVASVLPEGvDPALYARRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPI 161
Cdd:PRK13961  71 IVPNHLTGIDVDDVVPAD-EADQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYQATGTVCGIKLPAGLVEASKLPEPI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 162 FTPSTKAAVGDHDENIDFDAMVKQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMLTPD 241
Cdd:PRK13961 150 FTPATKAELGDHDENISFEEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDEDGTLTLMDEVLTPD 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896573033 242 SSRYWPADEYEVGTSPPSYDKQFVRDYLETLDWGKTAPGPTIPAEIIERTRAKYAEALQRLAGISVD 308
Cdd:PRK13961 230 SSRFWPADSYQPGTSQPSFDKQFVRDWLETSGWDKTAPAPPLPADVIEKTRAKYREALERLTGKSLD 296
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 15-304 1.12e-162

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 453.93  E-value: 1.12e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  15 LRHRGKVRDVFDiprerlpagtPPGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAHLMPNHLTGIDVAS 94
Cdd:cd01414    1 LIYSGKVRDVYD----------LGDGRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDIIPNHLISTDVED 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  95 vLPEGVDPALYARRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPIFTPSTKAAVGdHD 174
Cdd:cd01414   71 -LPEIKEPEDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVCGIKLPEGLREAQKLPEPIFTPSTKAEEG-HD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 175 ENIDFDAMVKQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMLTPDSSRYWPADEYEVG 254
Cdd:cd01414  149 ENISFEEAVEIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVLTPDSSRFWPADSYEPG 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 896573033 255 TSPPSYDKQFVRDYLETLDWGKT-APGPTIPAEIIERTRAKYAEALQRLAG 304
Cdd:cd01414  229 KEQPSFDKQFVRDWLEASGWDKQdPPPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 10-304 2.92e-120

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 345.14  E-value: 2.92e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  10 LPGLPLRHRGKVRDVFDIPrerlpagtppGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAHL-MPNHLT 88
Cdd:COG0152    1 MPKLELLYEGKVKDVYATD----------DDTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIgIPTHFI 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  89 GIDVAsvlpegvdpalyarRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRtgkvsGIDLPDGLRQAEQLPEPIFTPSTKA 168
Cdd:COG0152   71 ETLSG--------------REMLVKKLEMIPVEVVVRNYAAGSLWKRYQA-----GIALPLGLEEGTKLPEPIFEPSTKA 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 169 AVGdHDENIDFDAMVKQ--VGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMlTPDSSRYW 246
Cdd:COG0152  132 DEG-HDPNISEEHIVALglATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEI-TPDSSRLW 209

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 896573033 247 PADEYEvgtsppSYDKQFVRDYLETLdwgktapgptipaeiierTRAKYAEALQRLAG 304
Cdd:COG0152  210 DADTYE------SLDKDRFRDWLGGN------------------TSEAYIEVLERLTG 243
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 17-272 1.01e-99

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 292.34  E-value: 1.01e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   17 HRGKVRDVFDIPRErlpagtppgDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTA-HLMPNHLTgidvasv 95
Cdd:pfam01259   3 YEGKVKDVYETDDP---------DTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEiAGIPTHFI------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   96 lpEGVDPalyarRAVVTRKLKPVPVEAIARGYLIGSGWKDYQrtgkvsgidlpdGLRQAEQLPEPIFTPSTKAAVGdHDE 175
Cdd:pfam01259  67 --KSLSG-----REMLVKKVKIIPLEVVVRNYAAGSLGKRLP------------GLKEGTKLPEPIFEPSTKADAL-GDP 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  176 NIDFDAMVKQ--VGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMlTPDSSRYWPADEYEv 253
Cdd:pfam01259 127 NINEEHIVALglATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFGLDSDGEIVLADEI-TPDSSRFWDADTYE- 204

                         250
                  ....*....|....*....
gi 896573033  254 gTSPPSYDKQFVRDYLETL 272
Cdd:pfam01259 205 -KSQESLDKDRFRDDLGDV 222
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 14-304 1.18e-61

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 195.69  E-value: 1.18e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   14 PLRHRGKVRDVFDIPRERLpagtppgdyLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAH-LMPNHLTGidv 92
Cdd:TIGR00081   7 QKLYSGKAKDIYETDDPDL---------LRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEaGIPTHYID--- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   93 asvLPEGvdpalyarRAVVTRKLKPVPVEAIARGYLIGSGWKDYQrtgkvsgidLPDGLRQAEQLPEPIFTPstkAAVGD 172
Cdd:TIGR00081  75 ---LIED--------REMLVKKLDIIPLEVIVRNIAAGSLLKRLG---------IPEGLELEQPLVEFIFKP---DEVGD 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  173 HDENIDFDAMVKQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEmLTPDSSRYWPADEYE 252
Cdd:TIGR00081 132 PMLNESYAEALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGNLILADE-VSPDTCRLWDKETYE 210

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 896573033  253 VGTSPPsydkqfvrdyletldwgktapgptiPAEIIERTRAKYAEALQRLAG 304
Cdd:TIGR00081 211 VGAPKL-------------------------DKDIFRRTLGKLIEAYETVAR 237
 
Name Accession Description Interval E-value
PRK13961 PRK13961
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 2-308 0e+00

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237571  Cd Length: 296  Bit Score: 545.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   2 PTTLLQSDLPGLPLRHRGKVRDVFDIPrerlpagtppGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAH 81
Cdd:PRK13961   1 MSTLMESDLPSLPLLGRGKVRDIYAVD----------DDRLLMVATDRISAFDVILPEPIPDKGRVLTQMSNFWFDKLAH 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  82 LMPNHLTGIDVASVLPEGvDPALYARRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPI 161
Cdd:PRK13961  71 IVPNHLTGIDVDDVVPAD-EADQVLGRAVVVKKLKPLPVECVVRGYLTGSGWKDYQATGTVCGIKLPAGLVEASKLPEPI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 162 FTPSTKAAVGDHDENIDFDAMVKQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMLTPD 241
Cdd:PRK13961 150 FTPATKAELGDHDENISFEEVVELVGAELAAQLRDATLAIYKEAADYAATRGIIIADTKFEFGLDEDGTLTLMDEVLTPD 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896573033 242 SSRYWPADEYEVGTSPPSYDKQFVRDYLETLDWGKTAPGPTIPAEIIERTRAKYAEALQRLAGISVD 308
Cdd:PRK13961 230 SSRFWPADSYQPGTSQPSFDKQFVRDWLETSGWDKTAPAPPLPADVIEKTRAKYREALERLTGKSLD 296
SAICAR_synt_Sc cd01414
non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; ...
 15-304 1.12e-162

non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Eukaryotic, bacterial, and archaeal group of SAICAR synthetases represented by the Saccharomyces cerevisiae (Sc) enzyme, mostly absent in metazoans. SAICAR synthetase catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133469 [Multi-domain]  Cd Length: 279  Bit Score: 453.93  E-value: 1.12e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  15 LRHRGKVRDVFDiprerlpagtPPGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAHLMPNHLTGIDVAS 94
Cdd:cd01414    1 LIYSGKVRDVYD----------LGDGRLLFVATDRISAFDVILPPDIPGKGEVLTQISAFWFELTEDIIPNHLISTDVED 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  95 vLPEGVDPALYARRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKVSGIDLPDGLRQAEQLPEPIFTPSTKAAVGdHD 174
Cdd:cd01414   71 -LPEIKEPEDPDGRSMVVKKAKPIPIECIVRGYLTGSGWKEYQKGGTVCGIKLPEGLREAQKLPEPIFTPSTKAEEG-HD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 175 ENIDFDAMVKQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMLTPDSSRYWPADEYEVG 254
Cdd:cd01414  149 ENISFEEAVEIIGAELADELRELALALYERAAEYAAKRGLILADTKFEFGLDENGEIILIDEVLTPDSSRFWPADSYEPG 228

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 896573033 255 TSPPSYDKQFVRDYLETLDWGKT-APGPTIPAEIIERTRAKYAEALQRLAG 304
Cdd:cd01414  229 KEQPSFDKQFVRDWLEASGWDKQdPPPPPLPAEVIEKTSARYIEAYERITG 279
PurC COG0152
Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; ...
 10-304 2.92e-120

Phosphoribosylaminoimidazole-succinocarboxamide synthase [Nucleotide transport and metabolism]; Phosphoribosylaminoimidazole-succinocarboxamide synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439922  Cd Length: 245  Bit Score: 345.14  E-value: 2.92e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  10 LPGLPLRHRGKVRDVFDIPrerlpagtppGDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAHL-MPNHLT 88
Cdd:COG0152    1 MPKLELLYEGKVKDVYATD----------DDTLLMVFKDRISAFDGVKPDPIPGKGEVLNQISAFWFELLEDIgIPTHFI 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  89 GIDVAsvlpegvdpalyarRAVVTRKLKPVPVEAIARGYLIGSGWKDYQRtgkvsGIDLPDGLRQAEQLPEPIFTPSTKA 168
Cdd:COG0152   71 ETLSG--------------REMLVKKLEMIPVEVVVRNYAAGSLWKRYQA-----GIALPLGLEEGTKLPEPIFEPSTKA 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 169 AVGdHDENIDFDAMVKQ--VGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMlTPDSSRYW 246
Cdd:COG0152  132 DEG-HDPNISEEHIVALglATEEEAEELRELALKINERLSELAAERGIILVDTKLEFGRDADGEIVLADEI-TPDSSRLW 209

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 896573033 247 PADEYEvgtsppSYDKQFVRDYLETLdwgktapgptipaeiierTRAKYAEALQRLAG 304
Cdd:COG0152  210 DADTYE------SLDKDRFRDWLGGN------------------TSEAYIEVLERLTG 243
SAICAR_synt pfam01259
SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.
 17-272 1.01e-99

SAICAR synthetase; Also known as Phosphoribosylaminoimidazole-succinocarboxamide synthase.


Pssm-ID: 460140  Cd Length: 228  Bit Score: 292.34  E-value: 1.01e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   17 HRGKVRDVFDIPRErlpagtppgDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTA-HLMPNHLTgidvasv 95
Cdd:pfam01259   3 YEGKVKDVYETDDP---------DTLLVVAKDRISAFDGVKKGTIPGKGAVNNQISAFWFELLEiAGIPTHFI------- 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   96 lpEGVDPalyarRAVVTRKLKPVPVEAIARGYLIGSGWKDYQrtgkvsgidlpdGLRQAEQLPEPIFTPSTKAAVGdHDE 175
Cdd:pfam01259  67 --KSLSG-----REMLVKKVKIIPLEVVVRNYAAGSLGKRLP------------GLKEGTKLPEPIFEPSTKADAL-GDP 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  176 NIDFDAMVKQ--VGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMlTPDSSRYWPADEYEv 253
Cdd:pfam01259 127 NINEEHIVALglATEEEAEEIRELALKINEILKEYAAERGIILVDTKLEFGLDSDGEIVLADEI-TPDSSRFWDADTYE- 204

                         250
                  ....*....|....*....
gi 896573033  254 gTSPPSYDKQFVRDYLETL 272
Cdd:pfam01259 205 -KSQESLDKDRFRDDLGDV 222
PRK12607 PRK12607
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 2-304 1.51e-98

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 183621 [Multi-domain]  Cd Length: 313  Bit Score: 292.56  E-value: 1.51e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   2 PTTLLQSDLPGLPLRHRGKVRDVFDIPRERLpagtppgdylLMVATDRLSAFDVVLPdPIPGKGEMLCQVSNFWFAKTAH 81
Cdd:PRK12607   4 PRTLTEFNFPELPNVYRGKVRDNYDLPDGRR----------VMVATDRISAFDRVLP-AIPYKGQVLNQTAAFWFEATKD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  82 LMPNHLtgIDVasvlPegvDPALyarraVVTRKLKPVPVEAIARGYLIGSGWKDYQRtGK--VSGIDLPDGLRQAEQLPE 159
Cdd:PRK12607  73 ICPNHV--LAV----P---DPNV-----VVGKRCEPFPVEMVVRGYLAGSTWRLYKA-GKreMYGVTLPDGLRENQKLPE 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 160 PIFTPSTKAAVGDHDENIDFDAMVKQ--VGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEM 237
Cdd:PRK12607 138 PIITPTTKAEEGGHDEPISPEEILAQglLTPEDWDELSKYALALFARGQEMAAERGLILVDTKYEFGKDADGRIVLIDEI 217

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 896573033 238 LTPDSSRYWPADEYE----VGTSPPSYDKQFVRDYLETLDWGKTAPGPTIPAEIIERTRAKYAEALQRLAG 304
Cdd:PRK12607 218 HTPDSSRYWYADGYEerfaAGEPQEQLDKEFVRQWLIERCGPYGQEIPEIPDEVIVSVSERYIELYEKITG 288
PLN02544 PLN02544
phosphoribosylaminoimidazole-succinocarboxamide synthase
 4-288 2.11e-68

phosphoribosylaminoimidazole-succinocarboxamide synthase


Pssm-ID: 178159 [Multi-domain]  Cd Length: 370  Bit Score: 217.38  E-value: 2.11e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   4 TLLQSDLPGLPLRHRGKVRDVFDiprerlpagtpPGDYLLMVATDRLSAFDVVLPDpIPGKGEMLCQVSNFWFAKTAHLM 83
Cdd:PLN02544  66 TNLDLTVPGLGSRRRGKVRDIYD-----------LGDYLVLVTTDRQSAFDRVLAS-IPFKGQVLNQTSAWWFNNTKHIT 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  84 PNHLTGidvasvLPegvDPalyarRAVVTRKLKPVPVEAIARGYLIGSG----WKDYQRTGK-VSGIDLPDGLRQAEQLP 158
Cdd:PLN02544 134 PNALVS------SP---DP-----NVTIAKKCSVFPVEFVVRGYMTGSTstslWTVYNKGVRnYCGNDLPDGMVKNQKLP 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 159 EPIFTPSTKAAvgDHDENIDFDAMVKQ--VGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDE 236
Cdd:PLN02544 200 ANILTPTTKAA--DHDVPISPEEIVEEglMTQEDFDEVSSKALALFAFGQEVAAEHGLILVDTKYEFGKDADGTILLIDE 277

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 896573033 237 MLTPDSSRYWPADEYE----VGTSPPSYDKQFVRDYL-ETLDWGKTAPGPTIPAEII 288
Cdd:PLN02544 278 VHTPDSSRYWLADSYEerhaAGLEPENIDKEFLRLWFkENCDPYKDEVLPEAPAELV 334
purC TIGR00081
phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase ...
 14-304 1.18e-61

phosphoribosylaminoimidazole-succinocarboxamide synthase; Alternate name: SAICAR synthetase purine de novo biosynthesis. E.coli example noted as homotrimer. Check length. Longer versions may be multifunctional enzymes. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272897  Cd Length: 237  Bit Score: 195.69  E-value: 1.18e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   14 PLRHRGKVRDVFDIPRERLpagtppgdyLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKTAH-LMPNHLTGidv 92
Cdd:TIGR00081   7 QKLYSGKAKDIYETDDPDL---------LRFVFRDDISAFDGEKKDQIPGKGRLNTKISAFIFEKLEEaGIPTHYID--- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033   93 asvLPEGvdpalyarRAVVTRKLKPVPVEAIARGYLIGSGWKDYQrtgkvsgidLPDGLRQAEQLPEPIFTPstkAAVGD 172
Cdd:TIGR00081  75 ---LIED--------REMLVKKLDIIPLEVIVRNIAAGSLLKRLG---------IPEGLELEQPLVEFIFKP---DEVGD 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  173 HDENIDFDAMVKQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEmLTPDSSRYWPADEYE 252
Cdd:TIGR00081 132 PMLNESYAEALGLATEEELERIKELALKVNEVLKKYFDEKGIILVDFKLEFGLDEEGNLILADE-VSPDTCRLWDKETYE 210

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 896573033  253 VGTSPPsydkqfvrdyletldwgktapgptiPAEIIERTRAKYAEALQRLAG 304
Cdd:TIGR00081 211 VGAPKL-------------------------DKDIFRRTLGKLIEAYETVAR 237
SAICAR_synt cd00476
5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase ...
 18-302 1.87e-39

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; SAICAR synthetase (the PurC gene product) catalyzes the seventh step of the de novo biosynthesis of purine nucleotides (also reported as eighth step). It converts 5-aminoimidazole-4-carboxyribonucleotide (CAIR), ATP, and L-aspartate into 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR), ADP, and phosphate.


Pssm-ID: 133468  Cd Length: 230  Bit Score: 138.37  E-value: 1.87e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  18 RGKVRDVFDIPRerlpagtppgDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAKtahlmpnhLTGIDVASVLP 97
Cdd:cd00476    4 RGKTKIVYETKD----------GVLLLEFKDDISAGDGARRNFLDEKGDITAKLTLFIFKY--------LSEAGIPTHFV 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  98 EGVDPalyarRAVVTRKLKPVPVEAIARGYLIGSGWKDYQrtgkvsgidlpdGLRQAEQLPEPIFTPSTKAAvGDHDENI 177
Cdd:cd00476   66 ERLGP-----RTLLVDKLK*IPLEVVVRNRATGSFVKRYG------------GFKEGREFPPPLVEFFYKDD-AEHDPIV 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 178 DFD--AMVKQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEMLtPDSSRYWPADEYEVGt 255
Cdd:cd00476  128 SEDqlERLGFIGKVDVER*KELAVKINTVLKKLFSPAGLELWDFKLEFGLDEEGEIVLGDEIS-PDSSRLWRKGGEPYD- 205

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 896573033 256 sppsyDKQFVrdyletldwgktapgptiPAEIIERTRAKYAEALQRL 302
Cdd:cd00476  206 -----KDLFR------------------RRASLGQIIEKYEEVAELV 229
PRK13960 PRK13960
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 13-254 1.20e-33

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 184420  Cd Length: 367  Bit Score: 126.36  E-value: 1.20e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  13 LPLR-----HRGKVRDVFDIPRE---RL--------PAGTPpgdYLLMVATDRLSAFDVVLP-----DPIPGKGEMLCQV 71
Cdd:PRK13960  14 LPIRtdkpvHSGKVRSVYWLTEEdsrRLikekgynvPADAP---LAIMVISDRISAFDCIWHgegglNGVPGKGAALNAI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  72 SNFWFA--KTAHLMPNHLTGIdvasvlPEgvdPALYarravVTRKLKPVPVEAIARGYLIGSGWKDYQRTGKV-SGIDLP 148
Cdd:PRK13960  91 SNHWFKlfKENGLADSHILDI------PH---PFVW-----IVQKARPVMIEAICRQYITGSMWRAYSKGEREfCGITLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 149 DGLRQAEQLPEPIFTPSTK------AAVGDHDE-NIDFDAMVKQVGAELAERVRDATL------RIYKFAADYARERGIL 215
Cdd:PRK13960 157 EGLEKDQKLPELLITPSTKgiltgiPGVPEADDvNISRSDIEANYQAFNFSSADDIDLyekllkEGFKVISDALAKLDQI 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 896573033 216 LADTKFEFG--TDADG--RLYIMDEMLTPDSSRYWPADEYEVG 254
Cdd:PRK13960 237 FVDTKFEFGyvTDAAGneKLIYMDEVGTPDSSRIWDGAAYRDG 279
PRK13959 PRK13959
phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
 18-305 1.14e-22

phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional


Pssm-ID: 237570  Cd Length: 341  Bit Score: 95.90  E-value: 1.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  18 RGKVRDVFDiprERLPAGTPPGdYLLMVATDRLSAFDV-VLPDPIPGKGEMLCQVSNFWFAKTAHL-MPNHLTG-IDVAS 94
Cdd:PRK13959   1 MGSVKDFYV---DEEPTETDLG-RGRFVFSDRYSVFDWgIMPDEIPDKGASLCTMGAYNFELLEEEgIKTHYIGvVEDGE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  95 VLPEGVDPALYARRAV-VTRKLKP---------------------VPVEAIARGYL-IGSGWKDYQRTGKVS----GIDL 147
Cdd:PRK13959  77 VVRLAEASEPPNEMAVkLTQVPDLpfeggsydydayheaagenylIPLEVIFRNYVpVGSSLRDRIKEGKIKpedlGLDA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 148 PDGLRQAEQLPEPIFTPSTKAAvgDHDENIDFDAMVKQVGAELAE--RVRDATLRIYKFAADYARERGILLADTKFEFGT 225
Cdd:PRK13959 157 DEWPEEGVKLPEPIVEFSTKYE--EQDRYLSRKEADEIAGLSRAEieELEELALKVDEIITEEAEKRGLIHEDGKIEFAL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 226 DADGRLYIMDEMLTPDSSRYwpadEYE-VGTSppsydKQFVRDYLETLDW--------------GKTAPGPTIPA---EI 287
Cdd:PRK13959 235 YEEREIRVVDVVGTFDENRF----SYEgQELS-----KEVVRQYYRRTEWveavkeakeedvadWRSLCEPDPPPlpdEV 305

                        330
                 ....*....|....*...
gi 896573033 288 IERTRAKYAEALQRLAGI 305
Cdd:PRK13959 306 VEAVSDLYKAGTNAYTGR 323
PRK09362 PRK09362
phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed
 15-246 1.14e-16

phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed


Pssm-ID: 181800  Cd Length: 238  Bit Score: 77.45  E-value: 1.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  15 LRHRGKVRDVFDIPRErlpagtppgDYLLMVATDRLSAFDVVLPDPIPGKGEMLCQVSNFWFAK-TAHLMPNHLtgIDVA 93
Cdd:PRK09362   6 LLYEGKAKIVYSTDDP---------DLLIVEFKDDATAFNGEKKEQIDGKGVLNNQISSFIFKKlEEAGIPTHF--IEKL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033  94 SvlpegvdpalyARRAVVtRKLKPVPVEAIARGYLIGSGWKdyqRTGkvsgidLPDGlrqaEQLPEPIftpstkaavgdh 173
Cdd:PRK09362  75 S-----------DREQLV-KKVEIIPLEVVVRNVAAGSLVK---RLG------IEEG----TVLPPPI------------ 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896573033 174 denIDF--------DAMV--------KQVGAELAERVRDATLRIYKFAADYARERGILLADTKFEFGTDADGRLYIMDEm 237
Cdd:PRK09362 118 ---VEFyykndalgDPMInedhilalGWATPEELAEIKELALKINDVLKGLFAGAGIRLVDFKLEFGRDKDGEIVLADE- 193


                 ....*....
gi 896573033 238 LTPDSSRYW 246
Cdd:PRK09362 194 ISPDTCRLW 202
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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