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Conserved domains on  [gi|896611187|ref|WP_049493965|]
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MULTISPECIES: sensor histidine kinase [Streptococcus]

Protein Classification

sensor histidine kinase( domain architecture ID 11428470)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 214-317 2.03e-53

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16948:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 109  Bit Score: 170.54  E-value: 2.03e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 214 TDKKWLLVVIEQIISNSLKYTKEGG-LEIYME----GQELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYL 288
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSKQGGkIEIYSEtneqGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 896611187 289 SKKISEELGHQIRIESEVGKGTIVRIQFA 317
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
7-316 2.56e-40

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 143.90  E-value: 2.56e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187   7 FFLAYLRSRSRLFVYLISLTFLLLLFQFLFASLGIYFLYFFLLCCFVTILFFAWDILVEMQVYRQEILYGEREAQSPLER 86
Cdd:COG0642    7 LLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  87 VLAEKLEAREMELYQQRSDSERKLTDLLdyyTLWVHQIKTPIAA----SQLLVAEVADRQLK--QQLEQEIFKIDSYTNL 160
Cdd:COG0642   87 LLLLLLLLLLLALLLLLEEANEAKSRFL---ANVSHELRTPLTAirgyLELLLEELDEEQREylETILRSADRLLRLIND 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 161 VLQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLyDLDKE---IVTDKKWLLVVIEQIISNSLKYTKEG 237
Cdd:COG0642  164 LLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELEL-DLPDDlptVRGDPDRLRQVLLNLLSNAIKYTPEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 238 G---LEIYMEGQ--ELCIKDTGIGIKNSDVLRVFERGFSGYNGRlTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIV 312
Cdd:COG0642  243 GtvtVSVRREGDrvRISVEDTGPGIPPEDLERIFEPFFRTDPSR-RGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTF 321


                 ....
gi 896611187 313 RIQF 316
Cdd:COG0642  322 TVTL 325
 
Name Accession Description Interval E-value
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 214-317 2.03e-53

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 170.54  E-value: 2.03e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 214 TDKKWLLVVIEQIISNSLKYTKEGG-LEIYME----GQELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYL 288
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSKQGGkIEIYSEtneqGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 896611187 289 SKKISEELGHQIRIESEVGKGTIVRIQFA 317
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
7-316 2.56e-40

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 143.90  E-value: 2.56e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187   7 FFLAYLRSRSRLFVYLISLTFLLLLFQFLFASLGIYFLYFFLLCCFVTILFFAWDILVEMQVYRQEILYGEREAQSPLER 86
Cdd:COG0642    7 LLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  87 VLAEKLEAREMELYQQRSDSERKLTDLLdyyTLWVHQIKTPIAA----SQLLVAEVADRQLK--QQLEQEIFKIDSYTNL 160
Cdd:COG0642   87 LLLLLLLLLLLALLLLLEEANEAKSRFL---ANVSHELRTPLTAirgyLELLLEELDEEQREylETILRSADRLLRLIND 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 161 VLQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLyDLDKE---IVTDKKWLLVVIEQIISNSLKYTKEG 237
Cdd:COG0642  164 LLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELEL-DLPDDlptVRGDPDRLRQVLLNLLSNAIKYTPEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 238 G---LEIYMEGQ--ELCIKDTGIGIKNSDVLRVFERGFSGYNGRlTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIV 312
Cdd:COG0642  243 GtvtVSVRREGDrvRISVEDTGPGIPPEDLERIFEPFFRTDPSR-RGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTF 321


                 ....
gi 896611187 313 RIQF 316
Cdd:COG0642  322 TVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
122-316 1.73e-32

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 120.78  E-value: 1.73e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIA----ASQLLVAEVAD-----RQLKQQLEQEIFKIDSYTNLVLQYLRLESFHDDLVLKQVQIEDLVKEIIRKY 192
Cdd:COG2205   25 HELRTPLTsilgAAELLLDEEDLspeerRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAELLEEAVEEL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 193 ALFFIQKG--LNVNLYDLDKEIVTDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQ--ELCIKDTGIGIKNSDVLRV 265
Cdd:COG2205  105 RPLAEEKGirLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGtitISARREGDgvRISVSDNGPGIPEEELERI 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 896611187 266 FERGFSGYNGRlTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG2205  185 FERFYRGDNSR-GEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 214-316 1.71e-23

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 93.10  E-value: 1.71e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187   214 TDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQELC--IKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYL 288
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGritVTLERDGDHVEitVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100
                   ....*....|....*....|....*...
gi 896611187   289 SKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 214-316 2.92e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.95  E-value: 2.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  214 TDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQ-ELCIKDTGIGIKNSDVLRVFERGFSGYNGRltQQSSGLGLYLS 289
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGeitVTLSEGGElTLTVEDNGIGIPPEDLPRIFEPFSTADKRG--GGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*..
gi 896611187  290 KKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTL 105
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
122-314 8.96e-12

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 65.76  E-value: 8.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIAASQLLVaevadrqlkQQLEQEIFKIDS--YTNLVLQYL-RLESFHDDL---------VLKQVQIEDLVKEii 189
Cdd:PRK11360 399 HEIRNPLTAIRGYV---------QIWRQQTSDPPSqeYLSVVLREVdRLNKVIDQLlefsrpresQWQPVSLNALVEE-- 467

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 190 rkyALFFIQK-----GLNVNLyDLDKE---IVTDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEG---QELCIKDTGI 255
Cdd:PRK11360 468 ---VLQLFQTagvqaRVDFET-ELDNElppIWADPELLKQVLLNILINAVQAISARGkirIRTWQYSdgqVAVSIEDNGC 543

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 256 GIKNSDVLRVFERGFSgyngrlTQQS-SGLGLYLSKKISEELGHQIRIESEVGKGTIVRI 314
Cdd:PRK11360 544 GIDPELLKKIFDPFFT------TKAKgTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
PRK15347 PRK15347
two component system sensor kinase;
84-315 1.11e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 53.49  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  84 LERVLAEKleAREMELYQQRSD--SERK---LTDLldyytlwVHQIKTP----IAASQLLVAEVAD---RQLKQQLEQEI 151
Cdd:PRK15347 373 LENKVAER--TQALAEAKQRAEqaNKRKsehLTTI-------SHEIRTPlngvLGALELLQNTPLTaeqMDLADTARQCT 443

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 152 FKIDSYTNLVLQYLRLESFHDDLVLKQVQIEDLVKEiirkyALFFIQ-----KGLNVNLY---DLDKEIVTDKKWLLVVI 223
Cdd:PRK15347 444 LSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQ-----AMLTIQgpaqsKSLTLRTFvgaHVPLYLHLDSLRLRQIL 518

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 224 EQIISNSLKYTKEGG--LEIYMEGQELC--IKDTGIGIKNSDVLRVFErGFsgYNGRLTQQSSGLGLYLSKKISEELGHQ 299
Cdd:PRK15347 519 VNLLGNAVKFTETGGirLRVKRHEQQLCftVEDTGCGIDIQQQQQIFT-PF--YQADTHSQGTGLGLTIASSLAKMMGGE 595

                        250
                 ....*....|....*.
gi 896611187 300 IRIESEVGKGTIVRIQ 315
Cdd:PRK15347 596 LTLFSTPGVGSCFSLV 611
 
Name Accession Description Interval E-value
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 214-317 2.03e-53

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 170.54  E-value: 2.03e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 214 TDKKWLLVVIEQIISNSLKYTKEGG-LEIYME----GQELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYL 288
Cdd:cd16948    1 TDAKWLSFIIGQIVSNALKYSKQGGkIEIYSEtneqGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYL 80

                         90       100
                 ....*....|....*....|....*....
gi 896611187 289 SKKISEELGHQIRIESEVGKGTIVRIQFA 317
Cdd:cd16948   81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
7-316 2.56e-40

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 143.90  E-value: 2.56e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187   7 FFLAYLRSRSRLFVYLISLTFLLLLFQFLFASLGIYFLYFFLLCCFVTILFFAWDILVEMQVYRQEILYGEREAQSPLER 86
Cdd:COG0642    7 LLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  87 VLAEKLEAREMELYQQRSDSERKLTDLLdyyTLWVHQIKTPIAA----SQLLVAEVADRQLK--QQLEQEIFKIDSYTNL 160
Cdd:COG0642   87 LLLLLLLLLLLALLLLLEEANEAKSRFL---ANVSHELRTPLTAirgyLELLLEELDEEQREylETILRSADRLLRLIND 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 161 VLQYLRLESFHDDLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNLyDLDKE---IVTDKKWLLVVIEQIISNSLKYTKEG 237
Cdd:COG0642  164 LLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELEL-DLPDDlptVRGDPDRLRQVLLNLLSNAIKYTPEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 238 G---LEIYMEGQ--ELCIKDTGIGIKNSDVLRVFERGFSGYNGRlTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIV 312
Cdd:COG0642  243 GtvtVSVRREGDrvRISVEDTGPGIPPEDLERIFEPFFRTDPSR-RGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTF 321


                 ....
gi 896611187 313 RIQF 316
Cdd:COG0642  322 TVTL 325
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
122-316 1.73e-32

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 120.78  E-value: 1.73e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIA----ASQLLVAEVAD-----RQLKQQLEQEIFKIDSYTNLVLQYLRLESFHDDLVLKQVQIEDLVKEIIRKY 192
Cdd:COG2205   25 HELRTPLTsilgAAELLLDEEDLspeerRELLEIIRESAERLLRLIEDLLDLSRLESGKLSLELEPVDLAELLEEAVEEL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 193 ALFFIQKG--LNVNLYDLDKEIVTDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQ--ELCIKDTGIGIKNSDVLRV 265
Cdd:COG2205  105 RPLAEEKGirLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGtitISARREGDgvRISVSDNGPGIPEEELERI 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 896611187 266 FERGFSGYNGRlTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG2205  185 FERFYRGDNSR-GEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
122-316 1.59e-26

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 108.10  E-value: 1.59e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIAA----SQLLVAEVAD-----RQLKQQLEQEIFKIDSYTNLVLQYLRLESFHDDLVLKQVQIEDLVKEIIRKY 192
Cdd:COG5002  174 HELRTPLTSirgyLELLLDGAADdpeerREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEEL 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 193 ALFFIQKG--LNVNLYDLDKEIVTDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQELCI--KDTGIGIKNSDVLRV 265
Cdd:COG5002  254 RPLAEEKGieLELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGtitVSLREEDDQVRIsvRDTGIGIPEEDLPRI 333

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 896611187 266 FERGFSGYNGRLTQQS-SGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG5002  334 FERFYRVDKSRSRETGgTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 214-316 1.71e-23

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 93.10  E-value: 1.71e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187   214 TDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQELC--IKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYL 288
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGritVTLERDGDHVEitVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTGLGLSI 80

                           90       100
                   ....*....|....*....|....*...
gi 896611187   289 SKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:smart00387  81 VKKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 214-316 2.92e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.95  E-value: 2.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  214 TDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQ-ELCIKDTGIGIKNSDVLRVFERGFSGYNGRltQQSSGLGLYLS 289
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGeitVTLSEGGElTLTVEDNGIGIPPEDLPRIFEPFSTADKRG--GGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*..
gi 896611187  290 KKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTL 105
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 122-316 2.74e-17

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 81.93  E-value: 2.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIAASQLLvAEVADRQLKQQLEQEIFKIDSYTNLVLQYL-RLESFHDDL---------VLKQVQIEDLVKEIIRK 191
Cdd:COG5000  210 HEIKNPLTPIQLS-AERLRRKLADKLEEDREDLERALDTIIRQVdRLKRIVDEFldfarlpepQLEPVDLNELLREVLAL 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 192 YALFFIQKGLNVNLyDLDKEIVT---DKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQ--ELCIKDTGIGIKNSDVL 263
Cdd:COG5000  289 YEPALKEKDIRLEL-DLDPDLPEvlaDRDQLEQVLINLLKNAIEAIEEGGeieVSTRREDGrvRIEVSDNGPGIPEEVLE 367

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 896611187 264 RVFERGFSgyngrlTQQS-SGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG5000  368 RIFEPFFT------TKPKgTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 222-316 8.19e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 72.14  E-value: 8.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 222 VIEQIISNSLKYTKEGG--LEIYMEGQE-------LCIKDTGIGIKNSDVLRVFERgFSGYNGRLTQQS--SGLGLYLSK 290
Cdd:cd16922    4 ILLNLLGNAIKFTEEGEvtLRVSLEEEEedgvqlrFSVEDTGIGIPEEQQARLFEP-FSQADSSTTRKYggTGLGLAISK 82

                         90       100
                 ....*....|....*....|....*...
gi 896611187 291 KISEELGHQIRIESEVGKGTI--VRIQF 316
Cdd:cd16922   83 KLVELMGGDISVESEPGQGSTftFTLPL 110
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 54-314 1.69e-15

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 76.75  E-value: 1.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  54 TILFFAWDILVEMQVYRQEILYGEREAQSPLERVLAEKLEAREMELYQQRSDSERKLTDLLDY-YTLwVHQIKTPIAA-- 130
Cdd:COG4251  223 GGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFaYVA-SHDLREPLRKis 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 131 --SQLLV---AEVADRQLKQQLE---QEIFKIDSYTNLVLQYLRLESfhDDLVLKQVQIEDLVKEIIRKYALFFIQKGLN 202
Cdd:COG4251  302 gfSQLLEedyGDKLDEEGREYLErirDAAERMQALIDDLLAYSRVGR--QELEFEPVDLNELLEEVLEDLEPRIEERGAE 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 203 VNLYDLdKEIVTDKKWLLVVIEQIISNSLKYTKEG-------GLEIYMEGQELCIKDTGIGIKNSDVLRVFERgFSGYNG 275
Cdd:COG4251  380 IEVGPL-PTVRGDPTLLRQVFQNLISNAIKYSRPGepprieiGAEREGGEWVFSVRDNGIGIDPEYAEKIFEI-FQRLHS 457

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 896611187 276 RLTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRI 314
Cdd:COG4251  458 RDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYF 496
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
122-316 2.13e-12

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 67.18  E-value: 2.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIA----ASQLLVAEVADRQLK---QQLEQEIFKIDSYTNlvlqylRLESFHD--DLVLKQVQIEDLVKEIIRky 192
Cdd:COG3852  144 HEIRNPLTgirgAAQLLERELPDDELReytQLIIEEADRLNNLVD------RLLSFSRprPPEREPVNLHEVLERVLE-- 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 193 alfFIQKGLNVNL---YDLDK---EIVTDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQ------------ELCIK 251
Cdd:COG3852  216 ---LLRAEAPKNIrivRDYDPslpEVLGDPDQLIQVLLNLVRNAAEAMPEGGtitIRTRVERQvtlgglrprlyvRIEVI 292

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896611187 252 DTGIGIKnSDVL-RVFERGFSG-YNGrltqqsSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG3852  293 DNGPGIP-EEILdRIFEPFFTTkEKG------TGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
122-314 8.96e-12

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 65.76  E-value: 8.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIAASQLLVaevadrqlkQQLEQEIFKIDS--YTNLVLQYL-RLESFHDDL---------VLKQVQIEDLVKEii 189
Cdd:PRK11360 399 HEIRNPLTAIRGYV---------QIWRQQTSDPPSqeYLSVVLREVdRLNKVIDQLlefsrpresQWQPVSLNALVEE-- 467

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 190 rkyALFFIQK-----GLNVNLyDLDKE---IVTDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEG---QELCIKDTGI 255
Cdd:PRK11360 468 ---VLQLFQTagvqaRVDFET-ELDNElppIWADPELLKQVLLNILINAVQAISARGkirIRTWQYSdgqVAVSIEDNGC 543

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 256 GIKNSDVLRVFERGFSgyngrlTQQS-SGLGLYLSKKISEELGHQIRIESEVGKGTIVRI 314
Cdd:PRK11360 544 GIDPELLKKIFDPFFT------TKAKgTGLGLALSQRIINAHGGDIEVESEPGVGTTFTL 597
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 122-316 9.50e-12

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 65.20  E-value: 9.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIAA----SQLLVAEVADRQLKQQLEQEIFKIDSYTN----LVLQYLRLeSFHDDLVLKQVQIEDLVKEiirkyA 193
Cdd:COG4191  151 HEINNPLAAilgnAELLRRRLEDEPDPEELREALERILEGAEraaeIVRSLRAF-SRRDEEEREPVDLNELIDE-----A 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 194 LFFIQKGLNVNLYDLDKEIVTDKKWLLVV---IEQIISN-------SLKYTKEGGLEI--YMEGQELCI--KDTGIGIKN 259
Cdd:COG4191  225 LELLRPRLKARGIEVELDLPPDLPPVLGDpgqLEQVLLNllinaidAMEEGEGGRITIstRREGDYVVIsvRDNGPGIPP 304

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 260 SDVLRVFERGFSgyngrlT---QQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG4191  305 EVLERIFEPFFT------TkpvGKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 177-316 2.53e-11

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 64.23  E-value: 2.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 177 KQVQIEDLVKEIIrkyALF---------FIQKGLNVNLYDldkeIVTDKKWLLVVIEQIISNSLKYTKEGGlEIYMEGQ- 246
Cdd:COG5809  336 EPKDLNTLIEEVI---PLLqpqallknvQIELELEDDIPD----ILGDENQLKQVFINLLKNAIEAMPEGG-NITIETKa 407

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 896611187 247 ------ELCIKDTGIGIKNSDVLRVFERGFS-GYNGrltqqsSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG5809  408 edddkvVISVTDEGCGIPEERLKKLGEPFYTtKEKG------TGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 215-316 1.04e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 57.86  E-value: 1.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 215 DKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQELC--IKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYLS 289
Cdd:cd16975    1 DTLLLSRALINIISNACQYAPEGGtvsISIYDEEEYLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIA 80

                         90       100
                 ....*....|....*....|....*..
gi 896611187 290 KKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:cd16975   81 KNLVEKHGGSLIIENSQKGGAEVTVKI 107
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 209-316 3.68e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 56.65  E-value: 3.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 209 DKEIVTDKKWLLVVIEQIISNSLKYTKEGG-LEIYMEGQE---LCIKDTGIGIKNSDVLRVFERgFSGYNGRlTQQSSGL 284
Cdd:cd16940    4 DIQVQGDALLLFLLLRNLVDNAVRYSPQGSrVEIKLSADDgavIRVEDNGPGIDEEELEALFER-FYRSDGQ-NYGGSGL 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 896611187 285 GLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:cd16940   82 GLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 173-310 8.16e-10

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 59.95  E-value: 8.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 173 DLVLKQVQIEDLVKEIIRKYALFFIQKGLNVNL---YDLDKEIVTDKKWLLVVIEQIISNSLKYTKEGGLEI---YMEGQ 246
Cdd:PRK11091 350 QLDNQPIDFTDFLADLENLSGLQAEQKGLRFDLeplLPLPHKVITDGTRLRQILWNLISNAVKFTQQGGVTVrvrYEEGD 429

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 896611187 247 ELC--IKDTGIGIKNSDVLRVFERGF--SGYNGRLTQQSSGLGLYLSKKISEELGHQIRIESEVGKGT 310
Cdd:PRK11091 430 MLTfeVEDSGIGIPEDELDKIFAMYYqvKDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGS 497
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-310 1.60e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 54.64  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 222 VIEQIISNSLKYTKEG-------GLEIYMEGQELCIKDTGIGIK---NSDVLRVFER--GFSGYNGrltqqsSGLGLYLS 289
Cdd:cd16921    4 VLTNLLGNAIKFRRPRrpprievGAEDVGEEWTFYVRDNGIGIDpeyAEKVFGIFQRlhSREEYEG------TGVGLAIV 77

                         90       100
                 ....*....|....*....|.
gi 896611187 290 KKISEELGHQIRIESEVGKGT 310
Cdd:cd16921   78 RKIIERHGGRIWLESEPGEGT 98
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 219-315 1.74e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 54.22  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 219 LLVVIEQIISNSLKYT-------KEGGLEIYMEGQELCIK--DTGIGIKNSDVLRVFERGFS--GYNGRltqqssGLGLY 287
Cdd:cd16915    1 LITIVGNLIDNALDALaatgapnKQVEVFLRDEGDDLVIEvrDTGPGIAPELRDKVFERGVStkGQGER------GIGLA 74

                         90       100
                 ....*....|....*....|....*...
gi 896611187 288 LSKKISEELGHQIRIESEVGKGTIVRIQ 315
Cdd:cd16915   75 LVRQSVERLGGSITVESEPGGGTTFSIR 102
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 219-316 2.43e-09

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 57.94  E-value: 2.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 219 LLVVIEQIISNSLKYTKEGG-------LEIYMEGQELCI--KDTGIGIKNSDVLRVFERGFSGYNGrltqQSSGLGLYLS 289
Cdd:COG3290  282 LVTILGNLLDNAIEAVEKLPeeerrveLSIRDDGDELVIevEDSGPGIPEELLEKIFERGFSTKLG----EGRGLGLALV 357

                         90       100
                 ....*....|....*....|....*..
gi 896611187 290 KKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG3290  358 KQIVEKYGGTIEVESEEGEGTVFTVRL 384
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 115-314 3.31e-09

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 57.55  E-value: 3.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 115 DY-YTLwVHQIKTPIAA----SQLLVAEV--ADRQ-LKQQLEQEIFKIDSYTNLVLQYLRLESFHDDLVLKQVQIEDLVK 186
Cdd:PRK11100 258 QYvQTL-THELKSPLAAirgaAELLQEDPppEDRArFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLE 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 187 EIIRKYALFFIQKGLNVNLYDLDKEIVTDKKWLLVVIEQIISNSLKYTKEGG-----LEIYMEGQELCIKDTGIGIKNSD 261
Cdd:PRK11100 337 ELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGtitlsAEVDGEQVALSVEDQGPGIPDYA 416

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 896611187 262 VLRVFERGFS---GYNGRltqQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRI 314
Cdd:PRK11100 417 LPRIFERFYSlprPANGR---KSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATL 469
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 197-316 3.93e-09

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 57.43  E-value: 3.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 197 IQKGLNVNLYDLDK--EIVTDKKWLLVVIEQIISNSLKYTKEGG---LEIYMEGQE--LCIKDTGIGIKNSDVLRVFERG 269
Cdd:COG5805  372 ILHNIQIRLELLDEdpFIYCDENQIKQVFINLIKNAIEAMPNGGtitIHTEEEDNSviIRVIDEGIGIPEERLKKLGEPF 451

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 896611187 270 FSgyngrLTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG5805  452 FT-----TKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 248-316 4.22e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 53.54  E-value: 4.22e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 896611187 248 LCIKDTGIGIKNSDVLRVFERGFSgyngrlTQ---QSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:cd16919   50 LEVSDTGSGMPAEVLRRAFEPFFT------TKevgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 223-318 2.45e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 51.43  E-value: 2.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 223 IEQIISNSLKYTKEGGlEIYM------EGQELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTQQS-SGLGLYLSKKISEE 295
Cdd:cd16952    5 FSNLVSNAVKYTPPSD-TITVrwsqeeSGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHVMSR 83

                         90       100
                 ....*....|....*....|...
gi 896611187 296 LGHQIRIESEVGKGTIVRIQFAQ 318
Cdd:cd16952   84 HDARLLIASELGKGSRFTCLFPS 106
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 209-315 2.72e-08

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 54.92  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 209 DKEIVTDkkwLLVVIEQIISNSLK-YTKEGGLEI-----YMEGQELC-IKDTGIGIKNSDVLRVFERGFS--GyNGRltq 279
Cdd:PRK11086 427 DEDQVHE---LITILGNLIENALEaVGGEEGGEIsvslhYRNGWLHCeVSDDGPGIAPDEIDAIFDKGYStkG-SNR--- 499

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 896611187 280 qssGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQ 315
Cdd:PRK11086 500 ---GVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQ 532
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 242-314 9.42e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 49.34  E-value: 9.42e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 896611187 242 YMEGQELCIKDTGIGIKNSDVLRVFERGFSGyngRLTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRI 314
Cdd:cd16943   32 HVDQVLIEVEDTGSGIDPEILGRIFDPFFTT---KPVGEGTGLGLSLSYRIIQKHGGTIRVASVPGGGTRFTI 101
PRK15347 PRK15347
two component system sensor kinase;
84-315 1.11e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 53.49  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  84 LERVLAEKleAREMELYQQRSD--SERK---LTDLldyytlwVHQIKTP----IAASQLLVAEVAD---RQLKQQLEQEI 151
Cdd:PRK15347 373 LENKVAER--TQALAEAKQRAEqaNKRKsehLTTI-------SHEIRTPlngvLGALELLQNTPLTaeqMDLADTARQCT 443

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 152 FKIDSYTNLVLQYLRLESFHDDLVLKQVQIEDLVKEiirkyALFFIQ-----KGLNVNLY---DLDKEIVTDKKWLLVVI 223
Cdd:PRK15347 444 LSLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQ-----AMLTIQgpaqsKSLTLRTFvgaHVPLYLHLDSLRLRQIL 518

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 224 EQIISNSLKYTKEGG--LEIYMEGQELC--IKDTGIGIKNSDVLRVFErGFsgYNGRLTQQSSGLGLYLSKKISEELGHQ 299
Cdd:PRK15347 519 VNLLGNAVKFTETGGirLRVKRHEQQLCftVEDTGCGIDIQQQQQIFT-PF--YQADTHSQGTGLGLTIASSLAKMMGGE 595

                        250
                 ....*....|....*.
gi 896611187 300 IRIESEVGKGTIVRIQ 315
Cdd:PRK15347 596 LTLFSTPGVGSCFSLV 611
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 215-314 1.18e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 49.82  E-value: 1.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 215 DKKWLLVVIEQIISNSLKYTKEG---GLEIYMEGQELCIK--DTGIGIKNSDVLRVFERGFSGYNGRLT-QQSSGLGLYL 288
Cdd:cd16947   17 NTEALQRILKNLISNAIKYGSDGkflGMTLREDEKHVYIDiwDKGKGISETEKDHVFERLYTLEDSRNSaKQGNGLGLTI 96

                         90       100
                 ....*....|....*....|....*.
gi 896611187 289 SKKISEELGHQIRIESEVGKGTIVRI 314
Cdd:cd16947   97 TKRLAESMGGSIYVNSKPYEKTVFTV 122
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
122-314 2.80e-07

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 51.71  E-value: 2.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 122 HQIKTPIAA--------SQLLVAEVADRQLKQQLEQEIfkiDSYTNLVLQYLRLeSFHDDLVLKQVQIEDLVKEIIRKYA 193
Cdd:PRK10364 246 HEIRNPLSSikglakyfAERAPAGGEAHQLAQVMAKEA---DRLNRVVSELLEL-VKPTHLALQAVDLNDLINHSLQLVS 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 194 LFFIQKGLNVNLYDLD--KEIVTDKKWLLVVIEQIISNSLKYTKEGGLeIYMEGQE------LCIKDTGIGIKNSDVLRV 265
Cdd:PRK10364 322 QDANSREIQLRFTANDtlPEIQADPDRLTQVLLNLYLNAIQAIGQHGV-ISVTASEsgagvkISVTDSGKGIAADQLEAI 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 896611187 266 FERGFSGYNgrltqQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRI 314
Cdd:PRK10364 401 FTPYFTTKA-----EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 215-307 5.96e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 47.46  E-value: 5.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 215 DKKWLLVVIEQIISNSLKYTKEGG-LEIYM----EGQELCIKDTGIGIKNSDVLRVFERGFSGYNGRlTQQS--SGLGLY 287
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRYTDTGGkLRIRAaqtpQEVRLDVEDSAPGVSDDQLARLFERFYRVESSR-NRASggSGLGLA 79

                         90       100
                 ....*....|....*....|.
gi 896611187 288 LSKKISEELGHQIRIE-SEVG 307
Cdd:cd16946   80 ICHNIALAHGGTISAEhSPLG 100
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
222-314 6.07e-07

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 51.13  E-value: 6.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 222 VIEQIISNSLKYTKEGG--LEIYMEGQELC--IKDTGIGIKNSDVLRVFERGFS-GYNGRLTQQSSGLGLYLSKKISEEL 296
Cdd:PRK10841 566 VISNLLSNAIKFTDTGCivLHVRVDGDYLSfrVRDTGVGIPAKEVVRLFDPFFQvGTGVQRNFQGTGLGLAICEKLINMM 645

                         90       100
                 ....*....|....*....|
gi 896611187 297 GHQIRIESEVGKGTI--VRI 314
Cdd:PRK10841 646 DGDISVDSEPGMGSQftIRI 665
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
122-314 8.21e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 50.50  E-value: 8.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  122 HQIKTPIAASQLLVAEVADRQLKQQLEQEIFKIDSYTNL--------VLQYLRLESFHDDLVLKQVQIEDLVKEIIRKYA 193
Cdd:PRK09959  721 HEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQsllgligeILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFG 800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  194 LFFIQKGLNVNLYDL--DKEIVT-DKKWLLVVIEQIISNSLKYTKEGGLEI-----YMEGQELCIK----DTGIGIKNSD 261
Cdd:PRK09959  801 AIAASKSIALSCSSTfpDHYLVKiDPQAFKQVLSNLLSNALKFTTEGAVKIttslgHIDDNHAVIKmtimDSGSGLSQEE 880

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 896611187  262 VLRVFERGFSGYNGRlTQQSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRI 314
Cdd:PRK09959  881 QQQLFKRYSQTSAGR-QQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTI 932
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 215-302 8.43e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 46.68  E-value: 8.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 215 DKKWLLVVIEQIISNSLKYTKEGG-----LEIYMEGQELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTQQSSGLGLYLS 289
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSPEGGlialqLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80

                         90
                 ....*....|...
gi 896611187 290 KKISEELGHQIRI 302
Cdd:cd16945   81 QEVAQLHGGRITL 93
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-314 8.70e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 46.61  E-value: 8.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 222 VIEQIISNSLKYTKEGG---LEIYMEGQ--ELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTqQSSGLGLYLSKKISEEL 296
Cdd:cd16923    4 VFSNLLSNAIKYSPENTriyITSFLTDDvvNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNT-EGAGLGLSIAKAIIELH 82

                         90
                 ....*....|....*...
gi 896611187 297 GHQIRIESEvGKGTIVRI 314
Cdd:cd16923   83 GGSASAEYD-DNHDLFKV 99
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 211-316 1.12e-06

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 49.87  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 211 EIVTDKKWLLVVIEQIISNSLKYTKEGG-LEIYMEGQE----LCIKDTGIGIKNSDVLRVFERGFSgyngrLTQQSSGLG 285
Cdd:COG5806  304 YIEGDRQKLQQCLINIIKNGIEAMPNGGtLTIDVSIDKnkviISIKDTGVGMTKEQLERLGEPYFS-----TKEKGTGLG 378

                         90       100       110
                 ....*....|....*....|....*....|.
gi 896611187 286 LYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:COG5806  379 TMVSYRIIEAMNGTIRVESEVGKGTTFTITL 409
PRK09303 PRK09303
histidine kinase;
177-309 4.14e-06

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 48.02  E-value: 4.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 177 KQVQIEDLVKEIIRKYALFFIQKGLNVNlYDLDKEIVT---DKKWLLVVIEQIISNSLKYTKEGGL-EIYM-----EGQE 247
Cdd:PRK09303 229 QKLDLGSLCQEVILELEKRWLAKSLEIQ-TDIPSDLPSvyaDQERIRQVLLNLLDNAIKYTPEGGTiTLSMlhrttQKVQ 307

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 896611187 248 LCIKDTGIGIKNSDVLRVFERGFsgyngRLTQQSS----GLGLYLSKKISEELGHQIRIESEVGKG 309
Cdd:PRK09303 308 VSICDTGPGIPEEEQERIFEDRV-----RLPRDEGtegyGIGLSVCRRIVRVHYGQIWVDSEPGQG 368
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 223-310 5.20e-06

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 47.92  E-value: 5.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 223 IEQII----SNSLKYTKEGGLEIYMEGQELC---------IKDTGIGIKNSDVLRVFE----------RGFSGyngrltq 279
Cdd:PRK11107 409 LQQIItnlvGNAIKFTESGNIDILVELRALSntkvqlevqIRDTGIGISERQQSQLFQafrqadasisRRHGG------- 481

                         90       100       110
                 ....*....|....*....|....*....|.
gi 896611187 280 qsSGLGLYLSKKISEELGHQIRIESEVGKGT 310
Cdd:PRK11107 482 --TGLGLVITQKLVNEMGGDISFHSQPNRGS 510
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
207-316 2.92e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 42.98  E-value: 2.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 207 DLDKEIVTDkkwLLVVIEQIISNSLKYTKEGG------LEIYMEGQEL--CIKDTGIGIKNSDVLRVFErgfsgyngrlT 278
Cdd:COG2172   26 GLDEDDADD---LVLAVSEAVTNAVRHAYGGDpdgpveVELELDPDGLeiEVRDEGPGFDPEDLPDPYS----------T 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 896611187 279 QQSSGLGLYLSKKISEELGhqirIESEVGkGTIVRIQF 316
Cdd:COG2172   93 LAEGGRGLFLIRRLMDEVE----YESDPG-GTTVRLVK 125
PRK13557 PRK13557
histidine kinase; Provisional
 248-316 5.97e-05

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 44.66  E-value: 5.97e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 896611187 248 LCIKDTGIGIKNSDVLRVFERGFSgyngrlTQ---QSSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQF 316
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFFT------TKeegKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYF 392
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 222-314 6.81e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 41.28  E-value: 6.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 222 VIEQIISNSLKYtkeGGLEI----YMEGQELCIK--DTGIGIKNSDVLRVFERGFSGYNGRlTQQSSGLGLYLSKKISEE 295
Cdd:cd16950    4 VLSNLVDNALRY---GGGWVevssDGEGNRTRIQvlDNGPGIAPEEVDELFQPFYRGDNAR-GTSGTGLGLAIVQRISDA 79

                         90
                 ....*....|....*....
gi 896611187 296 LGHQIRIESEVGKGTIVRI 314
Cdd:cd16950   80 HGGSLTLANRAGGGLCARI 98
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 222-316 2.06e-04

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 40.43  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 222 VIEQIISNSLKYTKEG--GLEIYMEGQ----ELCIKDTGIGIknSDVLRVFERGFSgyngrlTQQSSGLGLYLSKKISEE 295
Cdd:cd16934   29 AVTELARNLLKHAGGGqvLLEVVAEGGrvalEILAVDQGPGI--ADVDEALRDGFS------TGGGLGLGLGGVRRLADE 100

                         90       100
                 ....*....|....*....|.
gi 896611187 296 LghqiRIESEVGKGTIVRIQF 316
Cdd:cd16934  101 F----DLHSAPGRGTVVVARK 117
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 66-315 3.40e-04

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 42.20  E-value: 3.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187  66 MQVYRQEI--LYGEREAQSPLERVLAEKLEAREMELYQQRSDSERKLTDLLDYYTLWVHQIKTPI----AASQLLvaevA 139
Cdd:PRK11466 395 MDAFRSNVhaLNRHREQLAAQVKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLygilGTAQLL----A 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 140 DRQLKQQLEQEIFKI-DSYTNL------VLQYLRLESFHDDLVLKQvqiEDLVKEIIRKYALFFIQKGLNVNLYDLDKEI 212
Cdd:PRK11466 471 DNPALNAQRDDLRAItDSGESLltilndILDYSAIEAGGKNVSVSD---EPFEPRPLLESTLQLMSGRVKGRPIRLATDI 547

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 213 VTD-KKWLL-------VVIEQIISNSLKYTKEGG--LEIYMEGQE--LCIKDTGIGIKNSDVLRVFERgFSGYNGRltQQ 280
Cdd:PRK11466 548 ADDlPTALMgdprrirQVITNLLSNALRFTDEGSivLRSRTDGEQwlVEVEDSGCGIDPAKLAEIFQP-FVQVSGK--RG 624

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 896611187 281 SSGLGLYLSKKISEELGHQIRIESEVGKGTIVRIQ 315
Cdd:PRK11466 625 GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLR 659
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 222-315 4.22e-04

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 39.40  E-value: 4.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 222 VIEQIISNSLKYTKEGG-----LEIY-MEGQELCIKDTGIGIKNSDVLRVFERgFSGYNGRLTQQ--SSGLGLYLSKKIS 293
Cdd:cd16925    8 VVLNLLSNAFKFTPDGGrirciLEKFrLNRFLLTVSDSGPGIPPNLREEIFER-FRQGDGSSTRAhgGTGLGLSIVKEFV 86

                         90       100
                 ....*....|....*....|..
gi 896611187 294 EELGHQIRIESEVGKGTIVRIQ 315
Cdd:cd16925   87 ELHGGTVTVSDAPGGGALFQVE 108
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
178-303 5.95e-04

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 41.16  E-value: 5.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 178 QVQIEDLVKEIIRKYALFFIQKGLNVNLyDLDKEIVT--DKKWLLVVIEQIISNSLKYTKEGG-LEIYMEGQE----LCI 250
Cdd:PRK10549 311 PVDLVPLLEVAGGAFRERFASRGLTLQL-SLPDSATVfgDPDRLMQLFNNLLENSLRYTDSGGsLHISAEQRDktlrLTF 389

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 896611187 251 KDTGIGIKNSDVLRVFERGFSGYNGRlTQQS--SGLGLYLSKKISEELGHQIRIE 303
Cdd:PRK10549 390 ADSAPGVSDEQLQKLFERFYRTEGSR-NRASggSGLGLAICLNIVEAHNGRIIAA 443
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 223-313 2.18e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 36.99  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 223 IEQIISNSLKYTKEGGLEIYMEGQEL--------------CIKDTGIGIKNSDVLRVFERGFsgyngrlTQQSSGL--GL 286
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGGCERRELtirtspaddravtiSVKDTGPGIAEEVAGQLFDPFY-------TTKSEGLgmGL 73

                         90       100
                 ....*....|....*....|....*..
gi 896611187 287 YLSKKISEELGHQIRIESEVGKGTIVR 313
Cdd:cd16920   74 SICRSIIEAHGGRLSVESPAGGGATFQ 100
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 183-316 2.83e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 37.23  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 183 DLVKEIIRKYALFFIQKGLNVNLyDLDKEI--VTDKKWLLVVIEQIISNSLKYTKEGGLEIYMEGQE---LCIKDTGIGI 257
Cdd:cd16954    1 PLLDSLCSALNKVYQRKGVSISL-DISPELrfPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGglhLIVDDDGPGV 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 896611187 258 KNSDVLRVFERGFsgyngRLTQQSSGLGLYLS--KKISEELGHQIRIE-SEVGkGTIVRIQF 316
Cdd:cd16954   80 PESQRSKIFQRGQ-----RLDEQRPGQGLGLAiaKEIVEQYGGELSLSdSPLG-GARFEVVF 135
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 247-309 4.08e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 36.28  E-value: 4.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 896611187 247 ELCIKDTGIGIKNSDVLRVFERGFSgynGRLTQQSSGLGLYLSKKISEELGHQIRIESEVGKG 309
Cdd:cd16976   36 VLVVRDNGPGIAEEHLSRVFDPFFT---TKPVGKGTGLGLSISYGIVEEHGGRLSVANEEGAG 95
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
248-310 6.54e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 38.12  E-value: 6.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 896611187 248 LCIKDTGIGIkNSDVL-RVFERGFSGYNGrltqqSSGLGLYLSKKISEELGHQIRIESEVGKGT 310
Cdd:PRK13837 610 LRVSDTGAGI-DEAVLpHIFEPFFTTRAG-----GTGLGLATVHGIVSAHAGYIDVQSTVGRGT 667
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
223-310 9.42e-03

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 37.68  E-value: 9.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896611187 223 IEQIISNSLKYTKEGGlEIYM------EGQELCIKDTGIGIKNSDVLRVFERGFSGYNGRLTQQS-SGLGLYLSKKiseE 295
Cdd:PRK11006 322 ISNLVYNAVNHTPEGT-HITVrwqrvpQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGgSGLGLAIVKH---A 397

                         90
                 ....*....|....*...
gi 896611187 296 LGH---QIRIESEVGKGT 310
Cdd:PRK11006 398 LSHhdsRLEIESEVGKGT 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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