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Conserved domains on  [gi|896641891|ref|WP_049521893|]
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MurR/RpiR family transcriptional regulator [Streptococcus mitis]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-260 5.78e-53

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 173.96  E-value: 5.78e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891   1 MDKPDIATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQ 80
Cdd:COG1737    2 MSAMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  81 ANQVSKHSPLTK---------RVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGV 151
Cdd:COG1737   82 LSSYERLRRLSPddsledilaKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 152 VCEALT-DQDGFAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPNKDSQTYTETVL-VATHSQSSY 229
Cdd:COG1737  162 NVVLLDgDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLyVPSEEPTLR 241

                        250       260       270
                 ....*....|....*....|....*....|.
gi 896641891 230 IQRISAQLPMLFFIDLIYAYFLEINRENKEK 260
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGDKARE 272
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-260 5.78e-53

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 173.96  E-value: 5.78e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891   1 MDKPDIATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQ 80
Cdd:COG1737    2 MSAMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  81 ANQVSKHSPLTK---------RVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGV 151
Cdd:COG1737   82 LSSYERLRRLSPddsledilaKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 152 VCEALT-DQDGFAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPNKDSQTYTETVL-VATHSQSSY 229
Cdd:COG1737  162 NVVLLDgDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLyVPSEEPTLR 241

                        250       260       270
                 ....*....|....*....|....*....|.
gi 896641891 230 IQRISAQLPMLFFIDLIYAYFLEINRENKEK 260
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGDKARE 272
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 113-248 1.75e-33

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 118.87  E-value: 1.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 113 QLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWTTSIMDENCLVLGFSLSGTTPSILDSLL 192
Cdd:cd05013    2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAE 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 896641891 193 DAKEMGAKTVLFSSVPN-KDSQTYTETVLVATHSQSSYIQRISAQLPMLFFIDLIYA 248
Cdd:cd05013   82 IAKERGAKVIAITDSANsPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFL 138
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
15-202 2.69e-23

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 96.37  E-value: 2.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  15 EEMTDLEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREF---IFQYQHQaeNQANQVSKHSP-- 89
Cdd:PRK11337  24 EGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLrsaLEDYFSQ--SEQVLHSELSFdd 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  90 ----LTKRVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWT 165
Cdd:PRK11337 102 apqdVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHIMLMS 181

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 896641891 166 TSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTV 202
Cdd:PRK11337 182 AALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKII 218
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 120-209 5.00e-11

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 59.23  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  120 LIEDAERVYFFGTGSSGLVAREMKLRFMRLGVVC----EALTDQDGFAwttSIMDENCLVLGFSLSGTTPSILDSLLDAK 195
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVveveLASELRHGVL---ALVDEDDLVIAISYSGETKDLLAAAELAK 77

                          90
                  ....*....|....
gi 896641891  196 EMGAKTVLFSSVPN 209
Cdd:pfam01380  78 ARGAKIIAITDSPG 91
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-260 5.78e-53

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 173.96  E-value: 5.78e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891   1 MDKPDIATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQ 80
Cdd:COG1737    2 MSAMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  81 ANQVSKHSPLTK---------RVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGV 151
Cdd:COG1737   82 LSSYERLRRLSPddsledilaKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 152 VCEALT-DQDGFAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPNKDSQTYTETVL-VATHSQSSY 229
Cdd:COG1737  162 NVVLLDgDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLyVPSEEPTLR 241

                        250       260       270
                 ....*....|....*....|....*....|.
gi 896641891 230 IQRISAQLPMLFFIDLIYAYFLEINRENKEK 260
Cdd:COG1737  242 SSAFSSRVAQLALIDALAAAVAQRDGDKARE 272
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 113-248 1.75e-33

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 118.87  E-value: 1.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 113 QLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWTTSIMDENCLVLGFSLSGTTPSILDSLL 192
Cdd:cd05013    2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAE 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 896641891 193 DAKEMGAKTVLFSSVPN-KDSQTYTETVLVATHSQSSYIQRISAQLPMLFFIDLIYA 248
Cdd:cd05013   82 IAKERGAKVIAITDSANsPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFL 138
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
15-202 2.69e-23

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 96.37  E-value: 2.69e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  15 EEMTDLEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREF---IFQYQHQaeNQANQVSKHSP-- 89
Cdd:PRK11337  24 EGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLrsaLEDYFSQ--SEQVLHSELSFdd 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  90 ----LTKRVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWT 165
Cdd:PRK11337 102 apqdVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHIMLMS 181

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 896641891 166 TSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTV 202
Cdd:PRK11337 182 AALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKII 218
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
16-246 3.30e-18

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 82.44  E-value: 3.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  16 EMTDLEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREF----IFQYQHQAENQ-ANQVSKHSPL 90
Cdd:PRK15482  13 EFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELrmalIGEYSASREKTnATALHLHSSI 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  91 T---------KRVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLG--VVCEAltDQ 159
Cdd:PRK15482  93 TsddsleviaRKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKIGyrVACEA--DT 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 160 DGFAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSV---PNKDSQTYT-ETVLVATHSQSSYIQRISA 235
Cdd:PRK15482 171 HVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSLadsPLRRLAHFTlDTVSGETEWRSSSMSTRTA 250

                        250
                 ....*....|...
gi 896641891 236 Q--LPMLFFIDLI 246
Cdd:PRK15482 251 QnsVTDLLFVGLV 263
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 103-212 4.12e-16

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 74.15  E-value: 4.12e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 103 EQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLG----VVCEAltdqdgfawTT-SIMDENCLVLg 177
Cdd:cd05005   12 ENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGlnvyVVGET---------TTpAIGPGDLLIA- 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 896641891 178 FSLSGTTPSILDSLLDAKEMGAKTVLFSSvpNKDS 212
Cdd:cd05005   82 ISGSGETSSVVNAAEKAKKAGAKVVLITS--NPDS 114
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
21-271 6.15e-16

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 75.96  E-value: 6.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  21 EQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREFIFQY-QHQAENQA-------NQVSKHSPLT- 91
Cdd:PRK11557  14 DRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALsEALASQPEppsvpvhNQIRGDDPLRl 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  92 ---KRVLRSYSNMReQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWTTSI 168
Cdd:PRK11557  94 vgeKLIKENTAAMR-ATLDVNSEEKLHECVTMLRSARRIILTGIGASGLVAQNFAWKLMKIGINAVAERDMHALLATVQA 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 169 MDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSS-VPNKDSQTYTETVLVATHSQSSYIQRISAQLPMLFFIDLIY 247
Cdd:PRK11557 173 LSPDDLLLAISYSGERRELNLAADEALRVGAKVLAITGfTPNALQQRASHCLYTIAEEQATRSAAISSTHAQGMLTDLLF 252

                        250       260
                 ....*....|....*....|....*
gi 896641891 248 AYFLEINREN-KEKIFNSYWENKKL 271
Cdd:PRK11557 253 MALIQQDLERaPERIRHSEALVKKL 277
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
43-240 3.08e-11

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 63.40  E-value: 3.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  43 VTQKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQA----NQVSKHSPLTKRVLRSYSNMREQTQDLIDEIQLERIA 118
Cdd:PRK14101 380 IARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIpmshSQVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVE 459

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 119 QLIE---DAERVYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAK 195
Cdd:PRK14101 460 QAIDilnNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDLYMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAM 539

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 896641891 196 EMGAKTVLFSSvPNKDSQTYTETVLVATHsqssyIQRISAQLPML 240
Cdd:PRK14101 540 QAGAKVIAITS-SNTPLAKRATVALETDH-----IEMRESQLSMI 578
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 120-209 5.00e-11

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 59.23  E-value: 5.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  120 LIEDAERVYFFGTGSSGLVAREMKLRFMRLGVVC----EALTDQDGFAwttSIMDENCLVLGFSLSGTTPSILDSLLDAK 195
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYKVveveLASELRHGVL---ALVDEDDLVIAISYSGETKDLLAAAELAK 77

                          90
                  ....*....|....
gi 896641891  196 EMGAKTVLFSSVPN 209
Cdd:pfam01380  78 ARGAKIIAITDSPG 91
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 6-69 2.98e-10

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 55.41  E-value: 2.98e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 896641891    6 IATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREF 69
Cdd:pfam01418   3 LLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPEL 66
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 127-205 3.25e-07

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 47.37  E-value: 3.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 127 VYFFGTGSSGLVAREMKLRFMRL-GVVCEALTDQDG-FAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLF 204
Cdd:cd04795    1 IFVIGIGGSGAIAAYFALELLELtGIEVVALIATELeHASLLSLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80


                 .
gi 896641891 205 S 205
Cdd:cd04795   81 T 81
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 101-209 3.66e-07

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 50.67  E-value: 3.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 101 MREQTQDLIDeiQLERIAQLIEDA---------ERVYFFGTGSSGLVAREMKLRFMR-LGVVCEALTDQDGFAWTTSIMD 170
Cdd:COG2222    4 IAQQPEAWRR--ALAALAAAIAALlarlrakppRRVVLVGAGSSDHAAQAAAYLLERlLGIPVAALAPSELVVYPAYLKL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 896641891 171 ENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPN 209
Cdd:COG2222   82 EGTLVVAISRSGNSPEVVAALELAKARGARTLAITNNPD 120
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 126-209 7.23e-07

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 47.11  E-value: 7.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 126 RVYFFGTGSS---GLVAREMKLRFMRLGVVCEALTDqdgFAWTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTV 202
Cdd:cd05008    1 RILIVGCGTSyhaALVAKYLLERLAGIPVEVEAASE---FRYRRPLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTV 77


                 ....*..
gi 896641891 203 LFSSVPN 209
Cdd:cd05008   78 AITNVVG 84
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 97-205 3.80e-05

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 43.27  E-value: 3.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  97 SYSNMREQTQDLIDEIQLERIAQLIEDA----ERVYFFGTGSSG----LVAREMKLRFM--RLGVVCEALTDqDGfAWTT 166
Cdd:cd05006    2 QESIQLKEALLELLAEAIEQAAQLLAEAllngGKILICGNGGSAadaqHFAAELVKRFEkeRPGLPAIALTT-DT-SILT 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 896641891 167 SIMDENC-----------------LVLGFSLSGTTPSILDSLLDAKEMGAKTVLFS 205
Cdd:cd05006   80 AIANDYGyeevfsrqvealgqpgdVLIGISTSGNSPNVLKALEAAKERGMKTIALT 135
PRK08674 PRK08674
bifunctional phosphoglucose/phosphomannose isomerase; Validated
 98-206 4.07e-05

bifunctional phosphoglucose/phosphomannose isomerase; Validated


Pssm-ID: 181536 [Multi-domain]  Cd Length: 337  Bit Score: 44.20  E-value: 4.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  98 YSNMREQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKlRFMRLGVVCEALTDQDGF--AWttsiMDENCLV 175
Cdd:PRK08674   8 YLNWPEQFEEALEIAISLDLEEDLEKIDNIVISGMGGSGIGGDLLR-ILLFDELKVPVFVNRDYTlpAF----VDEKTLV 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 896641891 176 LGFSLSGTTPSILDSLLDAKEMGAKTVLFSS 206
Cdd:PRK08674  83 IAVSYSGNTEETLSAVEQALKRGAKIIAITS 113
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 94-206 7.38e-05

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 41.81  E-value: 7.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891   94 VLRSYSNMREQtqdLIDEIqlERIAQLIEDA----ERVYFFGTGSSGLVAREMklrFMRLG-------VVCEALT----- 157
Cdd:pfam13580   6 VRALLERVVET---QADAI--EKAADLIAASlangGKVYAFGTGHSAAPAEEL---FARAGglagfepILLPALAlhtda 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 896641891  158 ---------DQDGFAwtTSIMD-----ENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSS 206
Cdd:pfam13580  78 satistaleRDEGYA--RQILAlypgrPGDVLIVISNSGINAVPVEAALEAKERGMKVIALTS 138
murQ PRK05441
N-acetylmuramic acid-6-phosphate etherase; Reviewed
 113-209 7.70e-05

N-acetylmuramic acid-6-phosphate etherase; Reviewed


Pssm-ID: 235467 [Multi-domain]  Cd Length: 299  Bit Score: 43.23  E-value: 7.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 113 QLERIAQLIEDAE-------RVYFFGTGSSGlvaremklrfmRLGVV----C-------------------EALTD---- 158
Cdd:PRK05441  44 ALPQIAAAVDAAAaalrqggRLIYIGAGTSG-----------RLGVLdaseCpptfgvppelvvgliaggeKALTKaveg 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 896641891 159 -----QDGFAWTTSI-MDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPN 209
Cdd:PRK05441 113 aeddaELGAADLKAInLTAKDVVVGIAASGRTPYVIGALEYARERGALTIGISCNPG 169
PRK02947 PRK02947
sugar isomerase domain-containing protein;
115-214 1.84e-04

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 41.78  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 115 ERIAQLIEDAERVYFFGTGSSGLVAREMklrFMRLG-------VVCEALT------------DQDGFAwtTSIMD----- 170
Cdd:PRK02947  31 DLIADSIRNGGLIYVFGTGHSHILAEEV---FYRAGglapvnpILEPSLMlhegavassyleRVEGYA--KAILDrydir 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 896641891 171 -ENCLVLgFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPNKDSQT 214
Cdd:PRK02947 106 pGDVLIV-VSNSGRNPVPIEMALEAKERGAKVIAVTSLAYSASVA 149
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
 113-209 2.19e-04

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 41.74  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 113 QLERIAQLIEDAE-------RVYFFGTGSSGlvaremklrfmRLGV--VCE---------------------ALT----- 157
Cdd:cd05007   31 ALPQIARAVDAAAerlraggRLIYVGAGTSG-----------RLGVldASElpptfgtppervvgliaggepALTraveg 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 896641891 158 --D--QDGFAWTTSIM-DENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFSSVPN 209
Cdd:cd05007  100 aeDdeEAGAADLQAINlTERDVVIGIAASGRTPYVLGALRYARARGALTIGIACNPG 156
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 10-153 2.39e-04

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 41.90  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  10 IDSHFEEMTDLEQEIARYFLQaetitddlSSQQVTqklHISQAALT-----------RFAKKCGFTGYREFIFQYQHQAE 78
Cdd:PRK11302   7 IQSRLEHLSKSERKVAEVILA--------SPQTAI---HSSIATLAkmanvseptvnRFCRSLDTKGFPDFKLHLAQSLA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891  79 NQANQVSKH-----SP--LTKRVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMR--L 149
Cdd:PRK11302  76 NGTPYVNRNveeddSVeaYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRfnV 155


                 ....
gi 896641891 150 GVVC 153
Cdd:PRK11302 156 PVVY 159
PRK00331 PRK00331
isomerizing glutamine--fructose-6-phosphate transaminase;
108-208 6.17e-04

isomerizing glutamine--fructose-6-phosphate transaminase;


Pssm-ID: 234729 [Multi-domain]  Cd Length: 604  Bit Score: 41.18  E-value: 6.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 108 LIDEIQLERIAQLIEDAERVYFFGTGSS---GLVAREMklrFMRL-GVVC------EaltdqdgFAWTTSIMDENCLVLG 177
Cdd:PRK00331 273 LDELGEGELADEDLKKIDRIYIVACGTSyhaGLVAKYL---IESLaGIPVeveiasE-------FRYRDPVLSPKTLVIA 342

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 896641891 178 FSLSGTTPSILDSLLDAKEMGAKT-----VLFSSVP 208
Cdd:PRK00331 343 ISQSGETADTLAALRLAKELGAKTlaicnVPGSTIA 378
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
 126-206 1.63e-03

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 37.63  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 126 RVYFFGTGSSGLVAREMKlRFMRLGVVCEALTDQDGFawTTSIMDENCLVLGFSLSGTTPSILDSLLDAKEMGAKTVLFS 205
Cdd:cd05017    1 NIVILGMGGSGIGGDLLE-SLLLDEAKIPVYVVKDYT--LPAFVDRKTLVIAVSYSGNTEETLSAVEQAKERGAKIVAIT 77


                 .
gi 896641891 206 S 206
Cdd:cd05017   78 S 78
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 103-206 2.03e-03

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 39.11  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896641891 103 EQTQDLIDEIQLERIAQLIEDAERVYFFGTGSSGLVAREMKLRFMrlgvvcEaLTDQDGFAWTT--------SIMDENCL 174
Cdd:COG2222  176 AALEAALAADWPAAALAALADAERVVFLGRGPLYGLAREAALKLK------E-LSAGHAEAYSAaefrhgpkSLVDPGTL 248

                         90       100       110
                 ....*....|....*....|....*....|...
gi 896641891 175 VLGFSLSGTTPSILDSLL-DAKEMGAKTVLFSS 206
Cdd:COG2222  249 VVVLASEDPTRELDLDLAaELRALGARVVAIGA 281
PRK13937 PRK13937
phosphoheptose isomerase; Provisional
 174-205 2.94e-03

phosphoheptose isomerase; Provisional


Pssm-ID: 184408 [Multi-domain]  Cd Length: 188  Bit Score: 37.91  E-value: 2.94e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 896641891 174 LVLGFSLSGTTPSILDSLLDAKEMGAKTVLFS 205
Cdd:PRK13937 109 VLIGISTSGNSPNVLAALEKARELGMKTIGLT 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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