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Conserved domains on  [gi|896679852|ref|WP_049554420|]
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MULTISPECIES: class II fructose-bisphosphate aldolase [Granulicatella]

Protein Classification

class II fructose-bisphosphate aldolase( domain architecture ID 10785082)

class II fructose-1,6-bisphosphate (FBP) aldolase catalyzes the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate

CATH:  3.20.20.70
EC:  4.1.2.13
Gene Ontology:  GO:0004332|GO:0006096|GO:0008270|GO:0030388
PubMed:  12206759|2199259|1412694
SCOP:  4003234

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-271 8.69e-114

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439961  Cd Length: 283  Bit Score: 328.59  E-value: 8.69e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   1 MKARMRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHL 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  81 DHGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFV-GANAASNNEEVKSIYTSVEDAK 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVgGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 160 KFVEETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAK 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 896679852 240 AVADGYVEN-----YIDIVNLSRKGMENTLEHYYKVF 271
Cdd:COG0191  241 AVREYLAENpdkydPRKYLKPAREAMKEVVKEKIRLF 277
 
Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-271 8.69e-114

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 328.59  E-value: 8.69e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   1 MKARMRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHL 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  81 DHGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFV-GANAASNNEEVKSIYTSVEDAK 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVgGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 160 KFVEETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAK 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 896679852 240 AVADGYVEN-----YIDIVNLSRKGMENTLEHYYKVF 271
Cdd:COG0191  241 AVREYLAENpdkydPRKYLKPAREAMKEVVKEKIRLF 277
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-271 1.79e-106

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 309.73  E-value: 1.79e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852    4 RMRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLS--LEDAAAIGRYFQEVTNTPVVLHLD 81
Cdd:pfam01116   2 NLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAggAEALAALVRAAAEAAGVPVALHLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   82 HGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEVKsIYTSVEDAKKF 161
Cdd:pfam01116  82 HGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEK-LYTDPEEAAEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  162 VEETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAV 241
Cdd:pfam01116 161 VEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAAV 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 896679852  242 ADGYVEN-YIDIVNLSRKGMENTLEHYYKVF 271
Cdd:pfam01116 241 REYPPNKdPRKYLRPAEEAMKEVVKEKIRLF 271
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-271 2.48e-98

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 289.04  E-value: 2.48e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQ 84
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  85 DFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEvKSIYTSVEDAKKFVEE 164
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGD-EGLLTDPEEAEEFVEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 165 TNVDSLAVSIGTSHGLYKG-TPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVAD 243
Cdd:cd00947  160 TGVDALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALRE 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 896679852 244 GYVEN-----YIDIVNLSRKGMENTLEHYYKVF 271
Cdd:cd00947  240 YLAENpkefdPRKYLAPAIEAVKEVVKHKMELF 272
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-271 5.12e-76

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 232.98  E-value: 5.12e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852    1 MKARMRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAA---IGRYFQEVTNTPVV 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAGLGAISamvKAMSEAYPYGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   78 LHLDHGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEVKS-IYTSVE 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESaLYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  157 DAKKFVEETNVDSLAVSIGTSHGLYKGTPK-LNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIY 235
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQI 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 896679852  236 SGAKAVADGYVEN--YID---IVNLSRKGMENTLEHYYKVF 271
Cdd:TIGR00167 242 AFAAAVRNYYAENkdYYDprvWLRPGEKAMKEVVLEKIKLF 282
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
5-231 3.90e-71

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 220.39  E-value: 3.90e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQ 84
Cdd:PRK06801   6 LANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARHDIPVVLNLDHGL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  85 DFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGAN--AASNNEEVKSIYTSVEDAKKFV 162
Cdd:PRK06801  86 HFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDegGALYGEADSAKFTDPQLARDFV 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896679852 163 EETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYS 231
Cdd:PRK06801 166 DRTGIDALAVAIGNAHGKYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINFYT 234
 
Name Accession Description Interval E-value
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-271 8.69e-114

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 328.59  E-value: 8.69e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   1 MKARMRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHL 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  81 DHGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFV-GANAASNNEEVKSIYTSVEDAK 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVgGEEDGVDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 160 KFVEETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAK 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 896679852 240 AVADGYVEN-----YIDIVNLSRKGMENTLEHYYKVF 271
Cdd:COG0191  241 AVREYLAENpdkydPRKYLKPAREAMKEVVKEKIRLF 277
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-271 1.79e-106

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 309.73  E-value: 1.79e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852    4 RMRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLS--LEDAAAIGRYFQEVTNTPVVLHLD 81
Cdd:pfam01116   2 NLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAggAEALAALVRAAAEAAGVPVALHLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   82 HGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEVKsIYTSVEDAKKF 161
Cdd:pfam01116  82 HGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEK-LYTDPEEAAEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  162 VEETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAV 241
Cdd:pfam01116 161 VEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTAAV 240

                         250       260       270
                  ....*....|....*....|....*....|.
gi 896679852  242 ADGYVEN-YIDIVNLSRKGMENTLEHYYKVF 271
Cdd:pfam01116 241 REYPPNKdPRKYLRPAEEAMKEVVKEKIRLF 271
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-271 2.48e-98

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 289.04  E-value: 2.48e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQ 84
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  85 DFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEvKSIYTSVEDAKKFVEE 164
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGD-EGLLTDPEEAEEFVEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 165 TNVDSLAVSIGTSHGLYKG-TPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVAD 243
Cdd:cd00947  160 TGVDALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALRE 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 896679852 244 GYVEN-----YIDIVNLSRKGMENTLEHYYKVF 271
Cdd:cd00947  240 YLAENpkefdPRKYLAPAIEAVKEVVKHKMELF 272
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-271 5.12e-76

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 232.98  E-value: 5.12e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852    1 MKARMRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAA---IGRYFQEVTNTPVV 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAGLGAISamvKAMSEAYPYGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   78 LHLDHGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEVKS-IYTSVE 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESaLYTDPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  157 DAKKFVEETNVDSLAVSIGTSHGLYKGTPK-LNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIY 235
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQI 241

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 896679852  236 SGAKAVADGYVEN--YID---IVNLSRKGMENTLEHYYKVF 271
Cdd:TIGR00167 242 AFAAAVRNYYAENkdYYDprvWLRPGEKAMKEVVLEKIKLF 282
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 5-271 6.80e-76

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 232.25  E-value: 6.80e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852    5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLED--AAAIGRYFQEVTNTPVVLHLDH 82
Cdd:TIGR01859   4 GKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGGYKmaVAMVKTLIERMSIVPVALHLDH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   83 GQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGAnAASNNEEVKSIYTSVEDAKKFV 162
Cdd:TIGR01859  84 GSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGG-IEDGVDEKEAELADPDEAEQFV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  163 EETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVA 242
Cdd:TIGR01859 163 KETGVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTDCRIAFTAAIR 242

                         250       260       270
                  ....*....|....*....|....*....|....
gi 896679852  243 DGYVEN--YID---IVNLSRKGMENTLEHYYKVF 271
Cdd:TIGR01859 243 KVLTEKkdEYDprkILGPAREAIKETVKEKMRLF 276
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
5-231 3.90e-71

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 220.39  E-value: 3.90e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQ 84
Cdd:PRK06801   6 LANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARHDIPVVLNLDHGL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  85 DFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGAN--AASNNEEVKSIYTSVEDAKKFV 162
Cdd:PRK06801  86 HFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDegGALYGEADSAKFTDPQLARDFV 165

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896679852 163 EETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYS 231
Cdd:PRK06801 166 DRTGIDALAVAIGNAHGKYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINFYT 234
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
6-274 4.36e-71

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 220.33  E-value: 4.36e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   6 RDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQD 85
Cdd:PRK12737   7 KNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARKYNIPLALHLDHHED 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  86 FEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAAS-NNEEVKSIYTSVEDAKKFVEE 164
Cdd:PRK12737  87 LDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDlVVDEKDAMYTNPDAAAEFVER 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 165 TNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVADG 244
Cdd:PRK12737 167 TGIDSLAVAIGTAHGLYKGEPKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNVATELKIAFSDAVKKY 246

                        250       260       270
                 ....*....|....*....|....*....|
gi 896679852 245 YVENyiDIVNLSRKGMENTLEHYYKVFETK 274
Cdd:PRK12737 247 FYEN--PKANDPRKYMTPGKAAMKEVVREK 274
PRK08185 PRK08185
hypothetical protein; Provisional
 5-235 1.97e-70

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 218.44  E-value: 1.97e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILayaQVHSQYLSL--EDAAAIGRYFQEVTNTPVVLHLDH 82
Cdd:PRK08185   1 MKELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAII---AIHPNELDFlgDNFFAYVRERAKRSPVPFVIHLDH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  83 GQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEVKSI-YTSVEDAKKF 161
Cdd:PRK08185  78 GATIEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSEIiYTDPEQAEDF 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 896679852 162 VEETNVDSLAVSIGTSHGLYK--GTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIY 235
Cdd:PRK08185 158 VSRTGVDTLAVAIGTAHGIYPkdKKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKY 233
PRK06806 PRK06806
class II aldolase;
4-229 3.91e-69

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 215.00  E-value: 3.91e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   4 RMRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHG 83
Cdd:PRK06806   5 QMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLIGPLMVAAAKQAKVPVAVHFDHG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  84 QDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGAnAASNNEEVKSIYTSVEDAKKFVE 163
Cdd:PRK06806  85 MTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGG-SEDGSEDIEMLLTSTTEAKRFAE 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 896679852 164 ETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINI 229
Cdd:PRK06806 164 ETDVDALAVAIGNAHGMYNGDPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINV 229
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 6-248 7.60e-69

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 214.61  E-value: 7.60e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   6 RDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQD 85
Cdd:PRK09195   7 KQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALHLDHHEK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  86 FEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAAS-NNEEVKSIYTSVEDAKKFVEE 164
Cdd:PRK09195  87 FDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDlQVDEADALYTDPAQAREFVEA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 165 TNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVADG 244
Cdd:PRK09195 167 TGIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFSQALKNY 246


                 ....
gi 896679852 245 YVEN 248
Cdd:PRK09195 247 LTEH 250
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
5-232 5.24e-68

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 212.28  E-value: 5.24e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQ 84
Cdd:PRK12857   6 VAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALHLDHGT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  85 DFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGAnaASNN---EEVKSIYTSVEDAKKF 161
Cdd:PRK12857  86 DFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGG--TEDDitvDEREAAMTDPEEARRF 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 896679852 162 VEETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSD 232
Cdd:PRK12857 164 VEETGVDALAIAIGTAHGPYKGEPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTN 234
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 6-248 3.09e-62

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 197.39  E-value: 3.09e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852    6 RDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQD 85
Cdd:TIGR01858   5 KYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGTEYIVALCSAASTTYNMPLALHLDHHES 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   86 FEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIG-FVGANAASNNEEVKSIYTSVEDAKKFVEE 164
Cdd:TIGR01858  85 LDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGrLGGVEDDLSVDEEDALYTDPQEAKEFVEA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  165 TNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVADG 244
Cdd:TIGR01858 165 TGVDSLAVAIGTAHGLYKKTPKLDFDRLAEIREVVDVPLVLHGASDVPDEDVRRTIELGICKVNVATELKIAFSGAVKAY 244


                  ....
gi 896679852  245 YVEN 248
Cdd:TIGR01858 245 FAEN 248
gatY PRK07998
class II aldolase;
5-268 4.05e-61

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 194.59  E-value: 4.05e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQ 84
Cdd:PRK07998   6 GRILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKMDVPVSLHLDHGK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  85 DFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIgfvGANAASNNEEVKSI--YTSVEDAKKFV 162
Cdd:PRK07998  86 TFEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAEL---GAILGKEDDHVSEAdcKTEPEKVKDFV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 163 EETNVDSLAVSIGTSHGLYKgTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVA 242
Cdd:PRK07998 163 ERTGCDMLAVSIGNVHGLED-IPRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIASDLRKAFITTVG 241

                        250       260
                 ....*....|....*....|....*...
gi 896679852 243 DGYVENY--IDIVNLSRKGMENTLEHYY 268
Cdd:PRK07998 242 KAYVNNHneANLARVMAKAKQAVEEDVY 269
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 5-243 3.79e-57

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 184.42  E-value: 3.79e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLS-LEDAAAIGRYFQEVTN--TPVVLHLD 81
Cdd:PRK08610   6 MKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYMSgFYTVVKMVEGLMHDLNitIPVAIHLD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  82 HGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGAnaasNNEEVKS---IYTSVEDA 158
Cdd:PRK08610  86 HGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGG----QEDDVVAdgiIYADPKEC 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 159 KKFVEETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGA 238
Cdd:PRK08610 162 QELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIASA 241


                 ....*
gi 896679852 239 KAVAD 243
Cdd:PRK08610 242 KAVRD 246
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
8-248 1.05e-56

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 183.31  E-value: 1.05e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   8 VLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQEVTNTPVVLHLDHGQDFE 87
Cdd:PRK12738   9 LLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLD 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  88 FIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEVKSIY-TSVEDAKKFVEETN 166
Cdd:PRK12738  89 DIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFlTDPQEAKRFVELTG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 167 VDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVADGYV 246
Cdd:PRK12738 169 VDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFA 248


                 ..
gi 896679852 247 EN 248
Cdd:PRK12738 249 EN 250
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
7-214 5.25e-53

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 174.78  E-value: 5.25e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   7 DVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLSLEDAAAIGRYFQE-VTNTPVVLHLDHGQD 85
Cdd:PRK05835   7 EILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCErYPHIPVALHLDHGTT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  86 FEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIG-FVGANAASNNEEVKSIYTSVEDAKKFVEE 164
Cdd:PRK05835  87 FESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGrLMGIEDNISVDEKDAVLVNPKEAEQFVKE 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 896679852 165 TNVDSLAVSIGTSHGL--YKGTPKLNFERLEELNEALTIPLVLHGGSGSGDD 214
Cdd:PRK05835 167 SQVDYLAPAIGTSHGAfkFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDD 218
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 5-241 9.91e-53

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 173.32  E-value: 9.91e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLS-LEDAAAIGRYFQEVTN--TPVVLHLD 81
Cdd:PRK07709   6 MKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTgFKTVVAMVKALIEEMNitVPVAIHLD 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  82 HGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGANAASNNEEvKSIYTSVEDAKKF 161
Cdd:PRK07709  86 HGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAE-GVIYADPAECKHL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 162 VEETNVDSLAVSIGTSHGLYKGTPKLNFERLEELNEALTIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAV 241
Cdd:PRK07709 165 VEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEFTKAV 244
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
6-232 2.80e-50

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 167.98  E-value: 2.80e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   6 RDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYL--SLEDAAAIG--RYFQEV-TNTPVVLHL 80
Cdd:PRK07084  13 REMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYAnaTLLRYMAQGavEYAKELgCPIPIVLHL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  81 DHGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVganaASNNEEV---KSIYTSVED 157
Cdd:PRK07084  93 DHGDSFELCKDCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVL----AGVEDEVsaeHHTYTQPEE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 158 AKKFVEETNVDSLAVSIGTSHGLYKGTP-----KLNFERLEELNEALT-IPLVLHGGS---------------------G 210
Cdd:PRK07084 169 VEDFVKKTGVDSLAISIGTSHGAYKFKPgqcppPLRFDILEEIEKRIPgFPIVLHGSSsvpqeyvktineyggklkdaiG 248

                        250       260
                 ....*....|....*....|..
gi 896679852 211 SGDDNLNRCATHGISKINIYSD 232
Cdd:PRK07084 249 IPEEQLRKAAKSAVCKINIDSD 270
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 8-268 1.05e-43

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 151.50  E-value: 1.05e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   8 VLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYA----------------QVHSQYLSLEDAAAIGRYFQEV 71
Cdd:cd00453    4 VFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSnggasfiagkgvksdvPQGAAILGAISGAHHVHQMAEH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  72 TNTPVVLHLDH--GQDFEFIKRAIELG-----------FNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVG 138
Cdd:cd00453   84 YGVPVILHTDHcaKKLLPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 139 A--NAASNNEEVKS-IYTSVEDAKKFVEETN----VDSLAVSIGTSHGLYK-GTPKLNFERLEELNEALT---------I 201
Cdd:cd00453  164 GeeDGVDNSHMDASaLYTQPEDVDYAYTELSkispRFTIAASFGNVHGVYKkGNVVLTPTILRDSQEYVSkkhnlphnsL 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896679852 202 PLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVADGYVEN--YIDIVNLSRKGMENTLEHYY 268
Cdd:cd00453  244 NFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANeaYLQGQLGNPKGEDQPNKKYY 312
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
5-209 2.98e-39

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 139.71  E-value: 2.98e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLIL-------AYAQvhSQYLS-LEDAAAigryfQEVTNTPV 76
Cdd:PRK09196   6 LRQLLDHAAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILqasagarKYAG--EPFLRhLILAAV-----EEYPHIPV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  77 VLHLDHGQDFEFIKRAIELGFNSVMIDASLD-------TFEENVRKTKDVVEYAHQFGVDVEAEIGFVG--------ANA 141
Cdd:PRK09196  79 VMHQDHGNSPATCQRAIQLGFTSVMMDGSLKadgktpaSYEYNVDVTRKVVEMAHACGVSVEGELGCLGsletgmggEED 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 896679852 142 ASNNEEVKS---IYTSVEDAKKFVEETNVDSLAVSIGTSHGLYKGTPK-----LNFERLEELNEAltIP---LVLHGGS 209
Cdd:PRK09196 159 GHGAEGKLShdqLLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTRKptgdvLAIDRIKEIHAR--LPnthLVMHGSS 235
PLN02858 PLN02858
fructose-bisphosphate aldolase
 6-229 8.42e-37

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 138.45  E-value: 8.42e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852    6 RDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILayaQVHSQYLSLED----AAAIGRyfQEVTNTPVVLHLD 81
Cdd:PLN02858 1103 KELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAIL---QVHPGALKQGGiplvSCCIAA--AEQASVPITVHFD 1177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   82 HGQDFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIG-FVGANAASNNEEVKSIYTSVEDAKK 160
Cdd:PLN02858 1178 HGTSKHELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGrLSGTEDGLTVEEYEAKLTDVDQAKE 1257

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 896679852  161 FVEETNVDSLAVSIGTSHGLYKGT-PKLNFERLEELNeALT----IPLVLHGGSGSGDDNLNRCATHGISKINI 229
Cdd:PLN02858 1258 FIDETGIDALAVCIGNVHGKYPASgPNLRLDLLKELR-ALSskkgVLLVLHGASGLPESLIKECIENGVRKFNV 1330
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 12-249 3.00e-33

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 122.69  E-value: 3.00e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  12 AKKEHYAVPA--TNFIDWNsaKAYSEISESRKLPLILAYAQVHSQYLS-LEDAAAIGRYFQEVTN--TPVVLHLDHGqDF 86
Cdd:PRK07315  13 ARDNGYAVGGfnTNNLEWT--QAILRAAEAKKAPVLIQTSMGAAKYMGgYKVCKNLIENLVESMGitVPVAIHLDHG-HY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  87 EFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFVGAnaasnnEEVKSIYTS----VEDAKKFV 162
Cdd:PRK07315  90 EDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGG------EEDGIIGKGelapIEDAKAMV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 163 eETNVDSLAVSIGTSHGLYKGTPK-LNFERLEELNEALT-IPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKA 240
Cdd:PRK07315 164 -ETGIDFLAAGIGNIHGPYPENWEgLDLDHLEKLTEAVPgFPIVLHGGSGIPDDQIQEAIKLGVAKVNVNTECQIAFANA 242


                 ....*....
gi 896679852 241 VADgYVENY 249
Cdd:PRK07315 243 TRK-FARDY 250
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
5-232 1.64e-32

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 122.20  E-value: 1.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   5 MRDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLIL-----AYAQVHSQYLS-LEDAAAigryfQEVTNTPVVL 78
Cdd:PRK13399   6 LRQLLDHAAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILqasrgARKYAGDAMLRhMVLAAA-----EMYPDIPICL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  79 HLDHGQDFEFIKRAIELGFNSVMIDASLD-------TFEENVRKTKDVVEYAHQFGVDVEAEIGFVGA-----------N 140
Cdd:PRK13399  81 HQDHGNSPATCQSAIRSGFTSVMMDGSLLadgktpaSYDYNVDVTRRVTEMAHAVGVSVEGELGCLGSletgeageedgV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 141 AASNNEEVKSIYTSVEDAKKFVEETNVDSLAVSIGTSHGLYKGTPK-----LNFERLEELNEAL-TIPLVLHGGSG---- 210
Cdd:PRK13399 161 GAEGKLSHDQMLTDPDQAVDFVQRTGVDALAIAIGTSHGAYKFTRKpdgdiLAIDRIEEIHARLpNTHLVMHGSSSvpqe 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 896679852 211 --------SGD---------DNLNRCATHGISKINIYSD 232
Cdd:PRK13399 241 lqeiinayGGKmketygvpvEEIQRGIKHGVRKVNIDTD 279
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 6-249 3.45e-21

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 91.28  E-value: 3.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   6 RDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYL------------SLEDAAAIGRYFQEVTN 73
Cdd:cd00946    5 LKLFDYAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGGAAFYagkglknekqkaSIAGAIAAAHHVRSMAE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  74 T---PVVLHLDHGQ-------------DFEFIKRAIELGFNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFV 137
Cdd:cd00946   85 HygvPVVLHTDHCAkkllpwfdglleaDEEYFKQHGEPLFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGIT 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 138 GANA-ASNNEEV--KSIYTSVEDAKKFVEETNVDS----LAVSIGTSHGLYK-GTPKLNFERLEE----------LNEAL 199
Cdd:cd00946  165 GGEEdGVDNSGVdnAELYTQPEDVWYVYEALSKISpnfsIAAAFGNVHGVYKpGNVKLQPEILGEhqdyvreklgLADDK 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 896679852 200 TIPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVADGYVENY 249
Cdd:cd00946  245 PLYFVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYLKNE 294
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 6-249 7.75e-18

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 81.77  E-value: 7.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852   6 RDVLGNAKKEHYAVPATNFIDWNSAKAYSEISESRKLPLILAYAQVHSQYLS---LED---------AAAIGRYFQEVT- 72
Cdd:PRK09197  10 QEMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGGAAFIAgkgVKDdgqgaavlgAIAGAKHVHEVAe 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  73 --NTPVVLHLDHGQD--FEFIKRAIELG-----------FNSVMIDASLDTFEENVRKTKDVVEYAHQFGVDVEAEIGFV 137
Cdd:PRK09197  90 hyGVPVILHTDHCAKklLPWIDGLLDAGekhfaaggkplFSSHMIDLSEEPLEENIEICSKYLERMAKAGMTLEIELGVT 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852 138 G------ANAASNNEEvksIYTSVEDAKKFVEETNVDS----LAVSIGTSHGLYK-GTPKLNFERLEELNEALT------ 200
Cdd:PRK09197 170 GgeedgvDNSHEDNSK---LYTQPEDVLYAYEALGKISgrftIAASFGNVHGVYKpGNVKLRPEILKDSQEYVSkkfglp 246

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 896679852 201 ---IPLVLHGGSGSGDDNLNRCATHGISKINIYSDFIYSGAKAVADGYVENY 249
Cdd:PRK09197 247 akpFDFVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDYYFKNY 298
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
44-121 2.90e-04

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 41.64  E-value: 2.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  44 LILAYAQVHSQY-----LSLEDAAAIgryfQEVTNTPVVLHLDHGQDFEFIKRAIELGFNSVMIDASLDtfEENVRKTKD 118
Cdd:PRK12857 172 LAIAIGTAHGPYkgepkLDFDRLAKI----KELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIR--EAFVARLRE 245


                 ...
gi 896679852 119 VVE 121
Cdd:PRK12857 246 VLE 248
LeuA COG0119
Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; ...
 85-158 3.95e-03

Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Isopropylmalate/homocitrate/citramalate synthases is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439889 [Multi-domain]  Cd Length: 452  Bit Score: 38.22  E-value: 3.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 896679852  85 DFEFIKRAIELGFNSVM----------IDASLD---------------------------TFEENVRKTKDVVEYAHQFG 127
Cdd:COG0119   53 DFEAVRRIAELGLDATIcalararrkdIDAALEalkgagvdrvhlfiktsdlhveyklrkTREEVLEMAVEAVKYAKEHG 132

                         90       100       110
                 ....*....|....*....|....*....|...
gi 896679852 128 VDVE--AEIGFvganaASNNEEVKSIYTSVEDA 158
Cdd:COG0119  133 LEVEfsAEDAT-----RTDPDFLLEVLEAAIEA 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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