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Conserved domains on  [gi|914276436|ref|WP_050561916|]
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iron ABC transporter permease [Serratia marcescens]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-342 1.54e-80

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 247.68  E-value: 1.54e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  35 LTVGAAQLGLTDIVRMLWpgSAPGNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFG 114
Cdd:COG0609    2 LSLGAVPISLSDVLRALL--GPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 115 AALAILTGFSLGgalALGTPLLASLMALLACVPVYLLGQR-RGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQIV 193
Cdd:COG0609   80 AVLAIVLGGGLS---ALGLPLAAFLGALLAALLVYLLARRgGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 194 FWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGF 273
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 914276436 274 VGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTRQ 342
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-342 1.54e-80

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 247.68  E-value: 1.54e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  35 LTVGAAQLGLTDIVRMLWpgSAPGNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFG 114
Cdd:COG0609    2 LSLGAVPISLSDVLRALL--GPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 115 AALAILTGFSLGgalALGTPLLASLMALLACVPVYLLGQR-RGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQIV 193
Cdd:COG0609   80 AVLAIVLGGGLS---ALGLPLAAFLGALLAALLVYLLARRgGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 194 FWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGF 273
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 914276436 274 VGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTRQ 342
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 33-341 1.25e-61

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 199.29  E-value: 1.25e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436   33 IDLTVGAAQLGLTDIVRMLwpgSAPGNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAG 112
Cdd:pfam01032   8 LSLFIGAVKISPSDVFSAL---LGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  113 FGAALAILTGFSLGgalALGTPLLASLMALLACVPVYLLGQ-RRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQ 191
Cdd:pfam01032  85 LGAVLAILLGGSLS---LFALPLAAFIGALLAALLVYFLSRgRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  192 IVFWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTI 271
Cdd:pfam01032 162 ILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPI 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  272 GFVGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTR 341
Cdd:pfam01032 242 GFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
33-342 4.96e-41

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 151.92  E-value: 4.96e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  33 IDLTVGAAQLGLTDIVRMLWPGSApgNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAG 112
Cdd:PRK10577  27 LTLTQLSAALPLSQWLQALWGPDA--DDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQ 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 113 FGAALAILTGFSLggaLALGTPLLASLMALLACVPVYLLGQRRGMTPQILVLSGIVVLFFFQSLQSLLLFlASPEAMQQI 192
Cdd:PRK10577 105 LALVLATLFAPAL---LALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTLLLL-FNEQYLQGL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 193 VFWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIG 272
Cdd:PRK10577 181 FLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIG 260

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 914276436 273 FVGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNG--VVPIGIVIALIGVPVLFYFVTRQ 342
Cdd:PRK10577 261 FIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTALIGAPLLLWLLPRL 332
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 74-339 6.51e-39

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 138.84  E-value: 6.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  74 TLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFGAALAILTGFSLGgalALGTPLLASLMALLACVPVYLLGQ 153
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLS---NYALGAFAFAGALAIALLVLLLAS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 154 RRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAmQQIVFWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALS 233
Cdd:cd06550   78 RGGLSPSKLILIGIVLSAFFSAGVILISLLSDDSL-QDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 234 AGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFVGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAK 313
Cdd:cd06550  157 FDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSR 236

                        250       260
                 ....*....|....*....|....*.
gi 914276436 314 LVMPNgVVPIGIVIALIGVPVLFYFV 339
Cdd:cd06550  237 TLLPS-ELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 35-342 1.54e-80

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 247.68  E-value: 1.54e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  35 LTVGAAQLGLTDIVRMLWpgSAPGNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFG 114
Cdd:COG0609    2 LSLGAVPISLSDVLRALL--GPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 115 AALAILTGFSLGgalALGTPLLASLMALLACVPVYLLGQR-RGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQIV 193
Cdd:COG0609   80 AVLAIVLGGGLS---ALGLPLAAFLGALLAALLVYLLARRgGGLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLRSIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 194 FWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGF 273
Cdd:COG0609  157 FWLMGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGF 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 914276436 274 VGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTRQ 342
Cdd:COG0609  237 VGLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRR 305
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 33-341 1.25e-61

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 199.29  E-value: 1.25e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436   33 IDLTVGAAQLGLTDIVRMLwpgSAPGNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAG 112
Cdd:pfam01032   8 LSLFIGAVKISPSDVFSAL---LGGDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGISSGAA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  113 FGAALAILTGFSLGgalALGTPLLASLMALLACVPVYLLGQ-RRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQ 191
Cdd:pfam01032  85 LGAVLAILLGGSLS---LFALPLAAFIGALLAALLVYFLSRgRGGASPLRLILAGIAVSALLSALTSLLLLLLNPEALQS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  192 IVFWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTI 271
Cdd:pfam01032 162 ILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGPI 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  272 GFVGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTR 341
Cdd:pfam01032 242 GFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 51-344 1.36e-45

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 158.09  E-value: 1.36e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  51 LWPgSAPGNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFGAALAILTGFSLGGALA 130
Cdd:COG4139   37 IPP-TQWLSEAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 131 LGTPLLASLMALLACVpvyLLGQRRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQIVFWLFGSLLKANMHGVAI 210
Cdd:COG4139  116 LSLAAIAGALLVTLLL---LAFARRRLSNARLLLIGVALGIICSAIMTWAVYFSSSLDLRQLMYWMMGSFGGVDWRQLWL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 211 TgVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFVGLIAPHFARFLVGEDQ 290
Cdd:COG4139  193 L-LALLPVLLWLCLQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDH 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 914276436 291 RYLICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTRQVK 344
Cdd:COG4139  272 RFLLPACALAGAALLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLRRRK 325
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 35-345 5.40e-42

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 149.12  E-value: 5.40e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  35 LTVGAAQLGLTDIVRMLWPGSAPGnelHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFG 114
Cdd:COG4779   41 LTLGDYPLSPGDVLRALLGEGDPG---ASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPDIIGITAGASAG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 115 AALAILtgfsLGGALALGTPLLASLMALLACVPVYLLGQRRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQIVF 194
Cdd:COG4779  118 AVAAIV----VLGGSGLAVALGALAGGLATALLVYLLAWRGGVSGYRLILVGIGVSAMLTAVNSYLLTRADLEDAQSAAV 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 195 WLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFV 274
Cdd:COG4779  194 WLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVATAAAGPIAFV 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914276436 275 GLIAPHFARFLVGEDQRYLICiSALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTRQVKR 345
Cdd:COG4779  274 ALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLLWLLIRENRR 343
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
33-342 4.96e-41

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 151.92  E-value: 4.96e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  33 IDLTVGAAQLGLTDIVRMLWPGSApgNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAG 112
Cdd:PRK10577  27 LTLTQLSAALPLSQWLQALWGPDA--DDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTTLGVAAGAQ 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 113 FGAALAILTGFSLggaLALGTPLLASLMALLACVPVYLLGQRRGMTPQILVLSGIVVLFFFQSLQSLLLFlASPEAMQQI 192
Cdd:PRK10577 105 LALVLATLFAPAL---LALASQLAAFAGGLLAAALVFALAGGKRLSPLRLVLAGMVVSLYLGALTTLLLL-FNEQYLQGL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 193 VFWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIG 272
Cdd:PRK10577 181 FLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAAVVSAVGPIG 260

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 914276436 273 FVGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNG--VVPIGIVIALIGVPVLFYFVTRQ 342
Cdd:PRK10577 261 FIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTALIGAPLLLWLLPRL 332
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 74-339 6.51e-39

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 138.84  E-value: 6.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  74 TLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFGAALAILTGFSLGgalALGTPLLASLMALLACVPVYLLGQ 153
Cdd:cd06550    1 LLAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLS---NYALGAFAFAGALAIALLVLLLAS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 154 RRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAmQQIVFWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALS 233
Cdd:cd06550   78 RGGLSPSKLILIGIVLSAFFSAGVILISLLSDDSL-QDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 234 AGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFVGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAK 313
Cdd:cd06550  157 FDEDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSR 236

                        250       260
                 ....*....|....*....|....*.
gi 914276436 314 LVMPNgVVPIGIVIALIGVPVLFYFV 339
Cdd:cd06550  237 TLLPS-ELPVGPVTALLGAPYFLYLL 261
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
66-345 1.01e-38

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 145.75  E-value: 1.01e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  66 FWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFGAalaILTGFSLGGALALGTPLLASLMALLAC 145
Cdd:PRK10577 393 LLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGV---VLALFLVPGAGFGWLLAAALLGALAAL 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 146 VPVYLLGQRRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEaMQQIVFWLFGSLLKANMHGVAITGVVLLCALFVSLRL 225
Cdd:PRK10577 470 ALILLLARRGGFAPERLLLTGIALSALFTALIQLLLASGDPR-AAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALLL 548

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 226 AWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFVGLIAPHFARFLVGEDQRYLICISALCGSLLL 305
Cdd:PRK10577 549 RRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLM 628

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 914276436 306 LCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTRQVKR 345
Cdd:PRK10577 629 VLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSRRR 668
btuC PRK09535
cobalamin ABC transporter permease BtuC;
53-341 4.05e-38

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 139.50  E-value: 4.05e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  53 PGSAPGNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFGAALAILtgfsLGGALALG 132
Cdd:PRK09535  78 PFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGAVAAIV----LPLAVPFG 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 133 TPLLASLMALLACVPVYLLGQRRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQIVFWLFGSLLKANMHGVAITG 212
Cdd:PRK09535 154 LQAAAFAGALVAAFGVYAIATENGRTPVATLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVAL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 213 VVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFVGLIAPHFARFLVGEDQRY 292
Cdd:PRK09535 234 PVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRI 313

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 914276436 293 LICISALCGSLLLLCASIVAKLvmPNGVVPIGIVIALIGVPVLFYFVTR 341
Cdd:PRK09535 314 LLPTSALAGASFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLRT 360
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
45-341 5.83e-35

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 130.20  E-value: 5.83e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  45 TDIVRMLWPGSAPGNELHQVVfwSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGIS------AAAGFGAALA 118
Cdd:PRK11228  28 ADALNALLPGHTPTLPEALVQ--NLRLPRSLVAVLIGASLALAGALLQTLTHNPLASPSLLGINsgaalaMALTSALSPT 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 119 ILTGFSL------GGALALGTpllaslmallacvpVYLLGQ--RRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAmQ 190
Cdd:PRK11228 106 PFAGYSLafiaacGGGLSWLL--------------VMTAGGgwRHTHDRNRLILAGIALSALCMALTRITLLLAEDHA-Y 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 191 QIVFWLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGT 270
Cdd:PRK11228 171 GIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLLVGACVSVAGP 250

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914276436 271 IGFVGLIAPHFARFLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTR 341
Cdd:PRK11228 251 VAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLARR 321
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 49-342 1.97e-34

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 128.92  E-value: 1.97e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  49 RMLWPGSaPGNELHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFGAALAILtgfsLGGA 128
Cdd:PRK03784  38 QWISPGD-WLSPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVL----LGQG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 129 LALGTPLLASLMALLACVPVYLLG--QRRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQIVFWLFGSLLKANMH 206
Cdd:PRK03784 113 LLPPWALSLCAIAGALLITLILLRfaRRHRLSTSRLLLAGVALGIICSALMTWAVYFSTSLDLRQLMYWMMGGFGGVDWR 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 207 gvaiTGVVLLCALFVSLRLAWR---LTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFVGLIAPHFAR 283
Cdd:PRK03784 193 ----QSWLMLALLPVLIWLCCQgrpLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILR 268

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 914276436 284 FLVGEDQRYLICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTRQ 342
Cdd:PRK03784 269 LCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRS 327
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
57-341 6.15e-30

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 116.30  E-value: 6.15e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  57 PGNElHQVVFWSIRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFGAALAILTGFSLG----GALALG 132
Cdd:PRK09777  39 AGDE-HYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGVNHAASLASVGALLLFPSLPvmwlPLLAFI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 133 TPLLASLMALLACVPvyllgqrrgMTPQILVLSGiVVLFFFQSLQSLLLFLASPEAMQQIVFWLFGSLLKANMHGVAITG 212
Cdd:PRK09777 118 GGMAGLILLKMLAGT---------HQPMKLALTG-VALSALWASLTDYLMLSRPQDINNALLWLTGSLWGRDWSFVKVAL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 213 VVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFVGLIAPHFARFLVGEDQRY 292
Cdd:PRK09777 188 PWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGVAACGPISFIGLVVPHLMRSLVGGRHRR 267

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 914276436 293 LICISALCGSLLLLCASIVAKLVMPNGVVPIGIVIALIGVPVLFYFVTR 341
Cdd:PRK09777 268 LLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVR 316
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
70-342 5.01e-29

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 114.42  E-value: 5.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  70 RLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFGaalaILTGFSLGGALA-LGTPLLASLMALLACVPV 148
Cdd:PRK10441  60 RLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFA----IVLGAALFGYSSaQEQLAMAFAGALVASLIV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 149 YLLGQRRG--MTPQILVLSGIVVLFFFQSLQSLLLFLaSPEAMQQIVFWLFGSLLKANMHGVAITGVVLLCALFVSLRLA 226
Cdd:PRK10441 136 AFTGSQGGgqLSPVRLTLAGVALAAVLEGLTSGIALL-NPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLS 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 227 WRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFVGLIAPHFARFLVGEDQRYLICISALCGSLLLL 306
Cdd:PRK10441 215 RALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLL 294

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 914276436 307 CASIVAKLVMPnGVVPIGIVIALIGVPVLFYFVTRQ 342
Cdd:PRK10441 295 FADIIGRLLVP-GELRVSVVSAFIGAPVLIFLVRRK 329
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
35-345 6.93e-22

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 94.39  E-value: 6.93e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436  35 LTVGAAQLGLTDIVRMLWpGSAPGNELHQVVFWsiRLPMTLTALVVGASLALAGLLMQTVLANPLASPYTLGISAAAGFG 114
Cdd:PRK10440  27 LRSGAVTLETSQVFAALM-GDAPRSMTMVVTEW--RLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGAWSG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 115 aalaILTGFSLGGALALGTPLLASLMALLACVPVYLLGQRRGMTPQILVLSGIVVLFFFQSLQSLLLFLASPEAMQQIVF 194
Cdd:PRK10440 104 ----VLVAMVLFGQDLTAIALAAMAGGIVTSLLVWLLAWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTAGL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914276436 195 WLFGSLLKANMHGVAITGVVLLCALFVSLRLAWRLTALSAGEEQAQGLGINVSALRKLGFLLATLLTAASVSFVGTIGFV 274
Cdd:PRK10440 180 WNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFI 259

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 914276436 275 GLIAPHFARFLVGEdQRYLICISALCGSLLLLCASIVAK-LVMPNGvVPIGIVIALIGVPVLFYFVTRQVKR 345
Cdd:PRK10440 260 ALVAPHIARRLSGT-ARWGLTQAALCGALLLLAADLCAQqLFMPYQ-LPVGVVTVSLGGIYLIVLLIQESRK 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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