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Conserved domains on  [gi|914577992|ref|WP_050594407|]
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MULTISPECIES: winged helix-turn-helix domain-containing protein [Serratia]

Protein Classification

winged helix-turn-helix domain-containing protein( domain architecture ID 10007860)

winged helix-turn-helix (wHTH) domain-containing protein binds DNA and may function as a transcriptional regulator

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  10473770|8831795|15808743
SCOP:  3000034

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
1-107 6.20e-27

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


:

Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 100.36  E-value: 6.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914577992   1 MEYVINQmIIFSPAERALFIINEResfMPLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNgfVGSNNNLNGCISEIRK 80
Cdd:COG3710    1 MRYRFGD-FRLDPARRELLRDGEP---VRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGR--VVSDNSLTQAISRLRK 74

                         90       100
                 ....*....|....*....|....*..
gi 914577992  81 AFESLALDPQIIITIPKLGFILEAEIT 107
Cdd:COG3710   75 ALGDDGLEPRLIRTVPRRGYRLVAPVE 101
 
Name Accession Description Interval E-value
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
1-107 6.20e-27

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 100.36  E-value: 6.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914577992   1 MEYVINQmIIFSPAERALFIINEResfMPLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNgfVGSNNNLNGCISEIRK 80
Cdd:COG3710    1 MRYRFGD-FRLDPARRELLRDGEP---VRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGR--VVSDNSLTQAISRLRK 74

                         90       100
                 ....*....|....*....|....*..
gi 914577992  81 AFESLALDPQIIITIPKLGFILEAEIT 107
Cdd:COG3710   75 ALGDDGLEPRLIRTVPRRGYRLVAPVE 101
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 29-102 2.51e-12

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 61.03  E-value: 2.51e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 914577992    29 PLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNgFVGSNNNLNGCISEIRKAFESlALDPQIIITIPKLGFIL 102
Cdd:smart00862   5 KLTPKEFRLLELLLRNPGRVVSREELLEAVWGDD-EDVDDNTLDVHISRLRKKLED-DGDPRLIETVRGVGYRL 76
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 9-102 3.98e-12

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 60.57  E-value: 3.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914577992   9 IIFSPAERALFIINEResfMPLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNGFVGSnNNLNGCISEIRKAFESLAlD 88
Cdd:cd00383    1 LRLDPARREVTVDGEE---VELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDD-RTVDVHISRLRKKLEDDP-E 75

                         90
                 ....*....|....
gi 914577992  89 PQIIITIPKLGFIL 102
Cdd:cd00383   76 PRLIKTVRGVGYRL 89
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
29-102 2.25e-10

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 55.60  E-value: 2.25e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 914577992   29 PLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNgFVGSNNNLNGCISEIRKAFESLALDPQIIITIPKLGFIL 102
Cdd:pfam00486   5 ELTPKEFKLLELLAENPGRVVSREQLLEEVWGED-YDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 37-110 3.09e-04

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 41.57  E-value: 3.09e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 914577992  37 LLLELVTHHKEMLTRRHLMQRVWeDNGFVgSNNNLNGCISEIRKAFESLALD-PQIIITIPKLGFILEAEITSCE 110
Cdd:PRK10153  36 LLVFFAQHSGEVLSRDELIDHVW-DRAIV-TDHVVTQSISELRKSLKDGREDnPEYIVTVPKRGYKLVAPVIWYS 108
 
Name Accession Description Interval E-value
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
1-107 6.20e-27

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 100.36  E-value: 6.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914577992   1 MEYVINQmIIFSPAERALFIINEResfMPLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNgfVGSNNNLNGCISEIRK 80
Cdd:COG3710    1 MRYRFGD-FRLDPARRELLRDGEP---VRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGR--VVSDNSLTQAISRLRK 74

                         90       100
                 ....*....|....*....|....*..
gi 914577992  81 AFESLALDPQIIITIPKLGFILEAEIT 107
Cdd:COG3710   75 ALGDDGLEPRLIRTVPRRGYRLVAPVE 101
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 29-102 2.51e-12

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 61.03  E-value: 2.51e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 914577992    29 PLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNgFVGSNNNLNGCISEIRKAFESlALDPQIIITIPKLGFIL 102
Cdd:smart00862   5 KLTPKEFRLLELLLRNPGRVVSREELLEAVWGDD-EDVDDNTLDVHISRLRKKLED-DGDPRLIETVRGVGYRL 76
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 9-102 3.98e-12

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 60.57  E-value: 3.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914577992   9 IIFSPAERALFIINEResfMPLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNGFVGSnNNLNGCISEIRKAFESLAlD 88
Cdd:cd00383    1 LRLDPARREVTVDGEE---VELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDD-RTVDVHISRLRKKLEDDP-E 75

                         90
                 ....*....|....
gi 914577992  89 PQIIITIPKLGFIL 102
Cdd:cd00383   76 PRLIKTVRGVGYRL 89
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
29-102 2.25e-10

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 55.60  E-value: 2.25e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 914577992   29 PLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNgFVGSNNNLNGCISEIRKAFESLALDPQIIITIPKLGFIL 102
Cdd:pfam00486   5 ELTPKEFKLLELLAENPGRVVSREQLLEEVWGED-YDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 37-110 3.09e-04

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 41.57  E-value: 3.09e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 914577992  37 LLLELVTHHKEMLTRRHLMQRVWeDNGFVgSNNNLNGCISEIRKAFESLALD-PQIIITIPKLGFILEAEITSCE 110
Cdd:PRK10153  36 LLVFFAQHSGEVLSRDELIDHVW-DRAIV-TDHVVTQSISELRKSLKDGREDnPEYIVTVPKRGYKLVAPVIWYS 108
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 10-94 2.20e-03

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 38.40  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914577992  10 IFSPAERALFIINEResfMPLSNPATRLLLELVTHHKEMLTRRHLMQRVWEDNGfvGSNNNLNGCISEIRKafeslALDP 89
Cdd:COG0745  130 LLDLAAREVTRDGEP---VELTPKEFRLLELLMRNPGRVVSREQLLEEVWGYDY--GDDRTVDVHISRLRK-----KLED 199


                 ....*
gi 914577992  90 QIIIT 94
Cdd:COG0745  200 DLIET 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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