NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803   20 ALTLKYFFKPKVTINYPFEKNPISPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIESEPREDGSRRTTRYDIDMT 99
Cdd:TIGR01971   3 GLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEINFG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 914606803  100 KCIYCGFCQEACPVDAVVEGPNFEYATETREELLYDKAKL 139
Cdd:TIGR01971  83 RCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 914606803  59 EERCIACKLCEAVCPAQAITIEsepredgsrRTTRYDIDMTKCIYCGFCQEACPVDAVV 117
Cdd:cd10549   77 EEKCIGCGLCVKVCPVDAITLE---------DELEIVIDKEKCIGCGICAEVCPVNAIK 126

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 914606803  24 KYFFKPKVTINYPFEKNPISPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIE 80
Cdd:NF038196 149 KKGPEKKKGFIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEME 205

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803   20 ALTLKYFFKPKVTINYPFEKNPISPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIESEPREDGSRRTTRYDIDMT 99
Cdd:TIGR01971   3 GLTLKYFFSKPVTVQYPEEKLYLPPRFRGRIVLTRDPNGEEKCIGCTLCAAVCPADAIRVVPAEGEDGKRRLKFYEINFG 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 914606803  100 KCIYCGFCQEACPVDAVVEGPNFEYATETREELLYDKAKL 139
Cdd:TIGR01971  83 RCIFCGLCEEACPTDAIVLTPEFELATYTRSDLVYGKEDL 122

formate hydrogenlyase complex iron-sulfur subunit; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803  30 KVTINYPFEKNPISPRFRG--EHALrrypngeERCIACKLCEAVCPAQAITIESepreDGSRRTTRYDIDMTKCIYCGFC 107
Cdd:PRK12387  13 TATSSYPLEPIAVDKNFRGkpEYNP-------QQCIGCAACVNACPSNALTVET----DLATGELAWEFNLGRCIFCGRC 81

                         90       100
                 ....*....|....*....|....*..
gi 914606803 108 QEACPVDAVVEGPNFEYATETREELLY 134
Cdd:PRK12387  82 EEVCPTAAIKLSQEFELAVWKKEDLLQ 108

hydrogenase 4 subunit H; Validated

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803  31 VTINYPFEKNPISPRFRGEHALrrypnGEERCIACKLCEAVCPAQAITIESEpREDGSRRttrYDIDMTKCIYCGFCQEA 110
Cdd:PRK08222  14 ATVKYPFAPLEVSPGFRGKPDL-----MPSQCIACGACTCACPANALTIQTD-DQQNSRT---WQLYLGRCIYCGRCEEV 84

                         90       100
                 ....*....|....*....|....*..
gi 914606803 111 CPVDAVVEGPNFEYATETREElLYDKA 137
Cdd:PRK08222  85 CPTRAIQLTNNFELTVTNKAD-LYTRA 110

putative oxidoreductase; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803  24 KYFFKPKVTINYPFEKNPISPRFRGEHAlrrypNGEERCIACKLCEAVCPAQAIT---IESEPREDGSrRTTRYDIDMTK 100
Cdd:PRK13984  14 KFLFRKPVTIKVPNVKREAAERYRGFHI-----NDWEKCIGCGTCSKICPTDAITmveVPDLPQEYGK-KPQRPVIDYGR 87

                         90
                 ....*....|.
gi 914606803 101 CIYCGFCQEAC 111
Cdd:PRK13984  88 CSFCALCVDIC 98

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 914606803  59 EERCIACKLCEAVCPAQAITIESEpredgsrrttRYDIDMTKCIYCGFCQEACPVDAV 116
Cdd:COG2221   14 EEKCIGCGLCVAVCPTGAISLDDG----------KLVIDEEKCIGCGACIRVCPTGAI 61

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 914606803   62 CIACKLCEAVCPAQAITIESEPREDGsrrTTRYDIDMTKCIYCGFCQEACPVDA 115
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGEKKG---TKTVVIDPERCVGCGACVAVCPTGA 51

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 914606803  59 EERCIACKLCEAVCPAQAITIESEpREDGSRRTTRYDIDMTKCIYCGFCQEACPVDA 115
Cdd:cd10549   39 EDKCVFCGACVEVCPTGAIELTPE-GKEYVPKEKEAEIDEEKCIGCGLCVKVCPVDA 94

NADH-plastoquinone oxidoreductase subunit; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803  23 LKYFFKPKVTINYP-FEKNPISPRFRGEHALRRypngeERCIACKLCEAVCPAQAITIESEPRedgsrrttRYDIDMTKC 101
Cdd:PRK08348   9 LRNLFKKPATNLFPaTEPVPVPEDFRGKILYDV-----DKCVGCRMCVTVCPAGVFVYLPEIR--------KVALWTGRC 75

                         90       100
                 ....*....|....*....|....*...
gi 914606803 102 IYCGFCQEACPVDAVVEGPNFEYATETR 129
Cdd:PRK08348  76 VFCGQCVDVCPTGALQMSDDFLLASYDR 103

Ferredoxin [Energy production and conversion];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 914606803  59 EERCIACKLCEAVCPAQAITIESEpredgsrrTTRYDIDMTKCIYCGFCQEACPVDA 115
Cdd:COG1145  181 AEKCIGCGLCVKVCPTGAIRLKDG--------KPQIVVDPDKCIGCGACVKVCPVGA 229

ferredoxin; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803  59 EERCIACKLCEAVCPAQAIT-IESEPRE--DGSRRTTRYDIDMTKCIYCGFCQEACPVDAVVEGPNFEYATETREELLYD 135
Cdd:PRK06273  48 EELCIGCGGCANVCPTKAIEmIPVEPVKitEGYVKTKIPKIDYEKCVYCLYCHDFCPVFALFNEISPIHPRDVGEDIEVD 127

                 ....*
gi 914606803 136 KAKLL 140
Cdd:PRK06273 128 VSKLL 132

Fe-S cluster domain-containing protein;

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 914606803  62 CIACKLCEAVCPAQAITIEsepredgsrrTTRYDIDMTKCIYCGFCQEACPVDAVVE 118
Cdd:PRK07118 215 CIGCGKCVKACPAGAITME----------NNLAVIDQEKCTSCGKCVEKCPTKAIRI 261

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 914606803  59 EERCIACKLCEAVCPAQAITIEseprEDGsrrttRYDIDMTKCIYCGFCQEACPVDAV 116
Cdd:COG1148  495 PEKCTGCGRCVEVCPYGAISID----EKG-----VAEVNPALCKGCGTCAAACPSGAI 543

hypothetical protein; Provisional

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 914606803  61 RCIACKLCEAVCPAQAITIESEPRedgsrrttRYDIDMTKCIYCGFCQEACPV 113
Cdd:PRK13795 582 ECVGCGVCVGACPTGAIRIEEGKR--------KISVDEEKCIHCGKCTEVCPV 626

Polyferredoxin NapH [Energy production and conversion];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 914606803  59 EERCIACKLCEAVCPAQAItiesePReDGSrrttrydIDMTKCIYCGFCQEACPVDAV 116
Cdd:COG0348  209 RGDCIDCGLCVKVCPMGID-----IR-KGE-------INQSECINCGRCIDACPKDAI 253

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 914606803  24 KYFFKPKVTINYPFEKNPISPRFRGEHALRRYPNGEERCIACKLCEAVCPAQAITIE 80
Cdd:NF038196 149 KKGPEKKKGFIPRLLSKLVNPLFYKFKVKDKKFHVTDKCIGCGICAKVCPVNNIEME 205

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914606803  60 ERCIACKLCEAVCPAQAITI-ESEPREDGSRRTTRYDIdMTKCIYC------G---FCQEACPVDA 115
Cdd:cd10551   83 DKCIGCRYCMAACPYGARYFnPEEPHEFGEVPVRPKGV-VEKCTFCyhrldeGllpACVEACPTGA 147

glycyl-radical enzyme activating protein; This subset of the radical-SAM family (pfam04055) includes a number of probable activating proteins acting on different enzymes all requiring an amino-acid-centered radical. The closest relatives to this family are the pyruvate-formate lyase activating enzyme (PflA, 1.97.1.4, TIGR02493) and the anaerobic ribonucleotide reductase activating enzyme (TIGR02491). Included within this subfamily are activators of hydroxyphenyl acetate decarboxylase (HdpA), benzylsuccinate synthase (BssD), gycerol dehydratase (DhaB2) as well as enzymes annotated in E. coli as activators of different isozymes of pyruvate-formate lyase (PFLC and PFLE) however, these appear to lack characterization and may activate enzymes with distinctive functions. Most of the sequence-level variability between these forms is concentrated within an N-terminal domain which follows a conserved group of three cysteines and contains a variable pattern of 0 to 8 additional cysteines.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914606803   40 NPISPRFRGEHALRrypngEERCIACKLCEAVCPAQAITIESepREDGSrrtTRYDIDMTKCIYCGFCQEACPVDA 115
Cdd:TIGR02494  33 NPESQRKSPELLFK-----ENRCLGCGKCVEVCPAGTARLSE--LADGR---NRIIIRREKCTHCGKCTEACPSGA 98

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 914606803  59 EERCIACKLCEAVCPAQAITIESEPREDGSrrttrydidmTKCIYCGF------CQEACPVDAVV 117
Cdd:COG1142   80 EEKCIGCGLCVLACPFGAITMVGEKSRAVA----------VKCDLCGGreggpaCVEACPTGALR 134

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 914606803  68 CEAVCPAQAITIesepREDGSRRttrydIDMTKCIYCGFCQEACPVDA 115
Cdd:COG0437   68 CVKVCPTGATYK----REDGIVL-----VDYDKCIGCRYCVAACPYGA 106

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 914606803  63 IACKLCEAVCPAQAITIEsePREDGSRRTTrydIDMTKCIYCGFCQEACPVDAV 116
Cdd:cd10564   86 VECRSCQDACPTQAIRFR--PRLGGIALPE---LDADACTGCGACVSVCPVGAI 134

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914606803  59 EERCIA------CKLCEAVCPAQAITIEsepREDGSRRTTrydIDMTKCIYCGFCQEACPV 113
Cdd:cd16373   90 KDRCLAwqggtdCGVCVEACPTEAIAIV---LEDDVLRPV---VDEDKCVGCGLCEYVCPV 144

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 914606803  61 RCIACKLCEAVCPAQAITIESEPREDGSRRTTRYDIDMTKCIYCGFCQEACPVDAV 116
Cdd:COG4624   53 RCCLCCCCCCRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAI 108

ferredoxin-like protein;

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 914606803  59 EERCIACKLCEAVCPAQAITIESEPREDgsrrttrydidmTKCIYCGFCQEACPVDAV 116
Cdd:PRK09898 153 HKRCIGCSACTTACPWMMATVNTESKKS------------SKCVLCGECANACPTGAL 198

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 914606803  62 CIACKL--CEAVCPAQAItiesEPREDGSRRTTRydidmTKCIYCGFCQEACPVDAV 116
Cdd:cd16370   53 CRACEDppCAEACPTGAL----EPRKGGGVVLDK-----EKCIGCGNCVKACIVGAI 100

succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803  40 NPISPRFRGEHALRRYPNGEER------CIACKLCEAVCPAQAIT-------------IESEPREDGSRRTTRYDIDMTK 100
Cdd:PRK06259 107 KSLRNYLQRKNEKITYPEDIEDikklrgCIECLSCVSTCPARKVSdypgptfmrqlarFAFDPRDEGDREKEAFDEGLYN 186

                         90
                 ....*....|..
gi 914606803 101 CIYCGFCQEACP 112
Cdd:PRK06259 187 CTTCGKCVEVCP 198

NAD-dependent dihydropyrimidine dehydrogenase subunit PreA;

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 914606803  59 EERCIACKLCEAVC---PAQAITIEseprEDGSRRttrYDIDMTKCIYCGFCQEACPVD 114
Cdd:PRK08318 341 QDKCIGCGRCYIACedtSHQAIEWD----EDGTRT---PEVIEEECVGCNLCAHVCPVE 392

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 914606803  60 ERCIACK--LCEAVCPAQAItiesEPREDGsrrttRYDIDMTKCIYCGFCQEACPVDAVV 117
Cdd:cd04410   48 VSCMHCEdpPCVKACPTGAI----YKDEDG-----IVLIDEDKCIGCGSCVEACPYGAIV 98

reductive dehalogenase; This model represents a family of corrin and 8-iron Fe-S cluster-containing reductive dehalogenases found primarily in halorespiring microorganisms such as dehalococcoides ethenogenes which contains as many as 17 enzymes of this type with varying substrate ranges. One example of a characterized species is the tetrachloroethene reductive dehalogenase (1.97.1.8) which also acts on trichloroethene converting it to dichloroethene.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914606803   62 CIACKLCEAVCPAQAITIESEPREDGSRRTTRYD----------IDMTKCI----------YCGFCQEACP 112
Cdd:TIGR02486 207 CETCGKCADECPSGAISKGGEPTWDPEDSNGDPPgennpglkwqYDGWRCLlfrcynegggGCGVCQAVCP 277

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 914606803  59 EERCIACKLCEAVCPAQAITIEseprEDGSRRttrydIDMTKCIYCGFCQEACPVD 114
Cdd:COG2878  136 EYGCIGCGDCIKACPFDAIVGA----AKGMHT-----VDEDKCTGCGLCVEACPVD 182

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 914606803   59 EERCIACKLCEAVCPAQAITiesepredGSRRTTRYDIdMTKCIYCGFCQEACPVDAVV 117
Cdd:TIGR01944 112 EDNCIGCTKCIQACPVDAIV--------GAAKAMHTVI-ADECTGCDLCVEPCPTDCIE 161

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 914606803  60 ERCIACKLCEAVCPA---QAITIESEPREDGSRRTTRYDIDMtkCIYC--GFCQEACPVDAVVEGPNF 122
Cdd:COG1142   10 EKCIGCRTCEAACAVaheGEEGEPFLPRIRVVRKAGVSAPVQ--CRHCedAPCAEVCPVGAITRDDGA 75

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 914606803  59 EERCIACKLCEAVCPaQAITIESEPREDGSRRTTRYDIDM----TKCIYCGF--CQEACPVDAVVEGP 120
Cdd:cd04410    5 LDRCIGCGTCEVACK-QEHGLRPGPDWSRIKVIEGGGLERaflpVSCMHCEDppCVKACPTGAIYKDE 71

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914606803  59 EERCIACKLCEAVCPAQAITIesePREDGSrrttrydidMTKCIYC------G---FCQEACPVDA 115
Cdd:cd16371   83 QDKCIGCGYCVWACPYGAPQY---NPETGK---------MDKCDMCvdrldeGekpACVAACPTRA 136

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];

                         10        20
                 ....*....|....*....|....*....
gi 914606803  93 RYDIDMTKCIYCGFCQEACPVDAVVEGPN 121
Cdd:COG4231   16 RYVIDEDKCTGCGACVKVCPADAIEEGDG 44

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 914606803  60 ERCIACKLCEAVC---------PAQA-ITIESEPREDgsrrttrYDIDMTkCIYCG--FCQEACPVDA 115
Cdd:cd10550    6 EKCTGCRTCELACslkhegvfnPSLSrIRVVRFEPEG-------LDVPVV-CRQCEdaPCVEACPVGA 65