|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
31-405 |
0e+00 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 551.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 31 ALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIE 110
Cdd:PRK11102 1 MLMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 111 ALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVIL 190
Cdd:PRK11102 81 QLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 191 AVSMKIPETLPAENRQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNI 270
Cdd:PRK11102 161 LVFFFIPETLPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 271 VAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMALLLSGYPNMA 350
Cdd:PRK11102 241 VFLFVMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALLDLGFWALVVGVAAFVGCVSMISSNAMAVILDEFPHMA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 914654497 351 GTASSLAGTLRFGTGSVVGAIVAMLPSDTAGPMAMMMAACAILSALLYWTLGKKA 405
Cdd:PRK11102 321 GTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSILFYLYASRPK 375
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
24-401 |
2.75e-99 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 300.26 E-value: 2.75e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 24 LILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVS 103
Cdd:cd17320 2 LLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 104 ATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAI 183
Cdd:cd17320 82 ALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 184 FAVIVILAVSMKIPETLPAENRQPLrFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFG 263
Cdd:cd17320 162 LGLLLLLLVLLFLPETLPEEKRKPL-LSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 264 YLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWML-DIGLWGIVPFVMLFIGTLSTIGSNSMALL 342
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 914654497 343 LSGYPNMAGTASSLAGTLRFGTGSVVGAIVAMLPSDTAGPMAMMMAACAILSALLYWTL 401
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
17-401 |
7.38e-93 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 284.28 E-value: 7.38e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 17 QLGLVLFLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLF 96
Cdd:TIGR00710 1 KSAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 97 AIASMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRS 176
Cdd:TIGR00710 81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 177 IFWVLAIFAVIVILAVSMKIPETLPAENRQPLRfkTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYG 256
Cdd:TIGR00710 161 IFAFLSLAGILLSALIFFILPETLPYEARIQIS--TYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 257 VRPDLFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIG-TLSTIG 335
Cdd:TIGR00710 239 VSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGiGNSMIS 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914654497 336 SNSMALLLSGYPNMAGTASSLAGTLRFGTGSVVGAIVAMLPSDTAGPMAMMMAACAILSALLYWTL 401
Cdd:TIGR00710 319 SIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYYL 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-367 |
4.12e-41 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 148.58 E-value: 4.12e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 15 TPQLGLVLFLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVF 94
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 95 LFAIASMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGW 174
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 175 RSIFWVLAIFAVIVILAVSMKIPETLPAENRQPLrfkttiRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDI 254
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLR------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 255 YGVRPDLFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAglglLVGWMLDIGLWGIVPFVMLFIGTLSTI 334
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG----LLLLALAGSLWLLLLALFLLGFGFGLL 313
|
330 340 350
....*....|....*....|....*....|....
gi 914654497 335 GSNSMALLLSGYP-NMAGTASSLAGTLRFGTGSV 367
Cdd:COG2814 314 FPLLQALVAELAPpEARGRASGLYNSAFFLGGPL 347
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
20-376 |
2.27e-38 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 142.35 E-value: 2.27e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 20 LVLFLILGAIGALTPlaiDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIA 99
Cdd:PRK11652 10 LFMLVLLVAVGQMAQ---TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 100 SMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFW 179
Cdd:PRK11652 87 TLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 180 VLAIFAVIVILAVSMKIPETLPAENRQPlrfkTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRP 259
Cdd:PRK11652 167 FLLLLGAGVTFSMARWMPETRPADARRT----RVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLSS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 260 DLFGYLFGLNIVAMILMTSINGRIVKKvgSHAMLRVGLTIQLFAGLGLLV-GWMLDIGLWG-IVPFVMLFIGT-----LS 332
Cdd:PRK11652 243 MTVSILFILPIPAAFFGAWFAGRPNKR--FSTLMWQSVICCLLAGLLMWIpGWFGVMNVWTlLVPAALFFFGAgmlfpLA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 914654497 333 TIGSnsmallLSGYPNMAGTASSLAGTLR-FGTGsVVGAIVAMLP 376
Cdd:PRK11652 321 TSGA------MEPFPYLAGTAGALLGGLQnIGSG-LAALLSAMLP 358
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
22-377 |
6.85e-32 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 124.62 E-value: 6.85e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 22 LFLI-LGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIAS 100
Cdd:PRK11043 6 GFLVyLAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 101 MVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDRED----FARTMSFVTLvmtvAPLVAPMIGGYLALWFGWRS 176
Cdd:PRK11043 86 LGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKanrvFATIMPLVAL----SPALAPLLGAWLLNHFGWQA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 177 IFWVLAIFAVIVILAvSMKIPETLPAENRQPLRFkttirNYARLCKNPTAMG--LIF---SGAFsfsgmFAFLTAGSFVY 251
Cdd:PRK11043 162 IFATLFAITLLLILP-TLRLKPSKKARKQSQDAL-----TFKQLLKSKTYLGnvLIFaacSAAF-----FAWLTGSPFIL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 252 IDiYGVRPDLFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGL-LVGWMLDIGLWGI-VPFVMLFI- 328
Cdd:PRK11043 231 EQ-MGYSPADIGLSYVPQTIAFLVGGYGCRAALQKWGGEQLLPWLLVLFAVSVIAIwLASLLSHPSLVPLlIPFCVMAAa 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 914654497 329 -GTLSTIGSNSMallLSGYPNMAGTASSLAGTLRFGTGSVVGAIVAMLPS 377
Cdd:PRK11043 310 nGAIYPIVVAQA---LRPFPQATGKAAALQNTLQLGLCFLASLLVSALIS 356
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-373 |
7.30e-30 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 118.44 E-value: 7.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 23 FLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMV 102
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 103 SATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWfGWRSIFWVLA 182
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 183 IFAVIVILAVSMKIPETLPAENRQPlrfKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLF 262
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSS---ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 263 GYLFGLNIVAMILMTSINGRIVKKvgshamlRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIgTLSTIGSNSM--- 339
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKK-------RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAI-VLFGLGLGLNlpl 308
|
330 340 350
....*....|....*....|....*....|....*..
gi 914654497 340 --ALLLSGYPNMA-GTASSLAGTLRFgTGSVVGAIVA 373
Cdd:cd17474 309 ltTLVTELAPEEErGTASSLYNFVRF-LGQAVGPLLF 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-400 |
1.48e-28 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 114.95 E-value: 1.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 42 PAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGF 121
Cdd:cd17324 20 GLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 122 AGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPETLP 201
Cdd:cd17324 100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 202 AENRQPLRFkttiRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTSING 281
Cdd:cd17324 180 KKPGSLGLL----SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 282 RIVKKVGSHAMLRVGLTIqlfaGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMALLLSGYPNMAGTASSLAGTLR 361
Cdd:cd17324 256 RLADRGGRRALLIALLLL----AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAY 331
|
330 340 350
....*....|....*....|....*....|....*....
gi 914654497 362 FGTGSVVGAIVAMLPSDTAGPMAMMMAACAILSALLYWT 400
Cdd:cd17324 332 NLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-375 |
6.74e-28 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 113.04 E-value: 6.74e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 32 LTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEA 111
Cdd:cd17321 7 LAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 112 LTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILA 191
Cdd:cd17321 87 LIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 192 VsmkipetlpaenrqplrfkttirnyarlcknPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIV 271
Cdd:cd17321 167 A-------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLAL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 272 AMILMTSINGRIVKKVGSHAMLRVGLTIqLFAGLGLLVGWMLDIGLWG-IVPFVMLFIGTLSTIGSNSMALLLSGYPNMA 350
Cdd:cd17321 216 AMLVAAPLAGRLADRFGPRLVLVAGLLL-TAVGLLLLALLGADSSVWLlLPGLVLLGLGLGLFATPLTNAALSSVPKEKA 294
|
330 340
....*....|....*....|....*
gi 914654497 351 GTASSLAGTLRFGTGSVVGAIVAML 375
Cdd:cd17321 295 GAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-367 |
1.05e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.43 E-value: 1.05e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 26 LGAIGALTPLAIDMYLPAMP-TIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSA 104
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 105 TTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIF 184
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 185 AVIVILAVSMKIPETLPAENRQPLRFKTTIRNYARLCKNPTAMGLIFsGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGY 264
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLL-ALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 265 LFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMALLLS 344
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|...
gi 914654497 345 GYPNMAGTASSLAGTLRFGTGSV 367
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
39-401 |
4.12e-26 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 108.05 E-value: 4.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 39 MYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTA 118
Cdd:cd17325 14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 119 QGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPE 198
Cdd:cd17325 94 QGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 199 TLPAENRQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTS 278
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 279 INGRIVKKVGSHAMLRVGLTIqlFAGLGLLVGWMLdiGLWGIVPFVMLFIGTLSTIGSNSMALLLSGYPNMA-GTASSLA 357
Cdd:cd17325 254 PAGKLSDRIGRKPLILIGLLL--SAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMGLF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 914654497 358 GTLrFGTGSVVGAIVAMLPSDTAGPMAMMMAACAILSALLYWTL 401
Cdd:cd17325 330 NTA-FSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
23-367 |
1.84e-25 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 106.51 E-value: 1.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 23 FLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMV 102
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 103 SATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLA 182
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 183 IFAVIVILAVSMKIPETLPaenrqplrfkttirnyarlcknptamgLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLF 262
Cdd:cd17323 161 IISGFCLILIFLFLPIVLL---------------------------LGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 263 GYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVG--------LTIQLFAGL----GLLV-GWMLDIGLWGIVPFVMLFIG 329
Cdd:cd17323 214 GLMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGgkpepearLPPAFIGAFlfpiGLFIfGWTIYPHIHWIVPIIGSAFF 293
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 914654497 330 TLST--IGSNSMALLLSGYPNMAGTASSLAGTLRFGTGSV 367
Cdd:cd17323 294 GFGLmlIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAI 333
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
18-223 |
2.17e-23 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 100.78 E-value: 2.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 18 LGLVLFLILgaigalTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFA 97
Cdd:PRK15402 16 LCLVLFEFA------TYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 98 IASMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSI 177
Cdd:PRK15402 90 LTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGM 169
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 914654497 178 FWVLAIFAVIVILAVSMKIPETLPAENRQpLRFKTTIRNYARLCKN 223
Cdd:PRK15402 170 FVLFAALAALSFFGLWRAMPETAGRVGEK-LSLKELGRDYKLVLKN 214
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
32-358 |
7.51e-23 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 99.33 E-value: 7.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 32 LTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEA 111
Cdd:PRK10473 14 LYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 112 LTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILA 191
Cdd:PRK10473 94 FLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 192 VSMKIPETLPAenrQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVrpDLFGYLFGLNIV 271
Cdd:PRK10473 174 SLFILKETRPA---RAPAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGF--SRGEYAIIMALT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 272 AMILMTS--INGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGivpFVMLFIGTLSTIGSnSMALLLSGYPNM 349
Cdd:PRK10473 249 AGVSMTVsfSTPFALGIFKPRTLMLTSQVLFLAAGITLALSPSHAVSLFG---ITLICAGFSVGFGV-AMSQALGPFSLR 324
|
....*....
gi 914654497 350 AGTASSLAG 358
Cdd:PRK10473 325 AGVASSTLG 333
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
43-375 |
1.34e-21 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 95.34 E-value: 1.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFA 122
Cdd:cd17503 18 ALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMkipetlpa 202
Cdd:cd17503 98 GGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 203 enrqpLRFkttirnyaRLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTSINGR 282
Cdd:cd17503 170 -----LDL--------RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 283 IVKKVGSHAMLRVGLTIqLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMALLLSGYP-NMAGTASSLAGTLR 361
Cdd:cd17503 237 LLDKFGPRLLLLAGLLL-LALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPpEQIGDATALFNTIR 315
|
330
....*....|....
gi 914654497 362 FGTGSVVGAIVAML 375
Cdd:cd17503 316 QLGGSIGTALLATL 329
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-405 |
4.40e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 90.70 E-value: 4.40e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 21 VLFLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIAS 100
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 101 MVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWV 180
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 181 LAIFAVIVILAvsmkipetlpaenrqplrfkttirnyarlcknpTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPD 260
Cdd:COG2271 170 LGLPGLLLALL---------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 261 LFGYLFGLNIVAMILMTSINGRIVKKVGSHAMlRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMA 340
Cdd:COG2271 217 QAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK-LVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914654497 341 LLLSGYPNMAGTASSLAGTLRFGTGSVVGAIVAMLPSDTA-GPMAMMMAACAILSALLYWTLGKKA 405
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGyQAAFLLLAALALLAALLALLLLRET 361
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
63-199 |
6.47e-20 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 85.39 E-value: 6.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 63 TAYTAGFALGQLLHGPLA----DSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMF 138
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 914654497 139 DREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPET 199
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-302 |
8.13e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 86.02 E-value: 8.13e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 22 LFLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASM 101
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 102 VSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVL 181
Cdd:COG0477 95 LCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 182 AIFAVIVILAVSMKIPETLPAENRQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDL 261
Cdd:COG0477 175 APLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLL 254
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 914654497 262 FGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLF 302
Cdd:COG0477 255 ALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-381 |
6.05e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 84.93 E-value: 6.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 21 VLFLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIAS 100
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 101 MVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWV 180
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 181 LAIFAVIVILAVSMKIPETLPAENRQPlrfKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPD 260
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAAAAA---KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 261 LFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLvgwMLDIGLWGIVPFVMLFIGTLSTIGSNSMA 340
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA---LALGSLWLFLVLFLLLGLALGGGNGAVFA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 914654497 341 LLLSGYP-NMAGTASSLAGTLrFGTGSVVGAIVAMLPSDTAG 381
Cdd:COG2223 319 LVPDIFPtKNAGAVYGLVGAA-GGLGGFLGPLLFGALLDATG 359
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-382 |
3.47e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.47 E-value: 3.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 26 LGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSAT 105
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 106 THGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALW--FGWRSIFWVLAI 183
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 184 FAVIVILAVSMKIPET--LPAENRQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDL 261
Cdd:cd06174 161 LALLAAILLLLVVPDPpeSARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 262 FGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIqlFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMAL 341
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLL--LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 914654497 342 LLSGYPNMAGTASSLAGTLRFGTGSVVGAIVAMLPSDTAGP 382
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
35-318 |
6.36e-17 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 81.80 E-value: 6.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 35 LAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTY 114
Cdd:PRK15403 30 LTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 115 IRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSM 194
Cdd:PRK15403 110 ARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 195 KIPETLPAENRqPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMI 274
Cdd:PRK15403 190 AMPETVKRGAV-PFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTSQFAWTQVPVFGAVI 268
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 914654497 275 LMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLW 318
Cdd:PRK15403 269 VANAIVARFVKDPTEPRFIWRAVPIQLVGLALLIVGNLLWPHVW 312
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
35-329 |
3.94e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.18 E-value: 3.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 35 LAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTY 114
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 115 IRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAV-S 193
Cdd:cd17489 90 LRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVfL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 194 MKIPETLPAENRQPL-RFKTTIRNYARLcknPTAMGLIFSgAFSFSGMFAFLTagsfVYIDIYGVrpDLFGYLFGLNIVA 272
Cdd:cd17489 170 VKDPPPVAAEEAEAGtRAFRRLVEKKVL---PPALILFLA-SIAYGAISTFLP----LYAAERGI--SNAGLFFTVYAIA 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 914654497 273 MILMTSINGRIVKKVGSHAMLRVGLtiqLFAGLGLLVGWMLDIGLWGIVPFVMLFIG 329
Cdd:cd17489 240 LLLSRPFSGKLSDRKGPKTVIIPGL---LLLALGLLLLSFAGSPWMLLLAAVLYGLG 293
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
24-347 |
5.94e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 75.69 E-value: 5.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 24 LILGAIGALTPLAIDMYLPAMPTIAKD-LGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMV 102
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 103 SATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALwFGWRSIFWVLA 182
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 183 iFAVIVILAVSMKIPETLPAENRQPLRFKTTirnyARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLF 262
Cdd:cd17473 161 -LALPVLILVLLFLPEPARKSKSAASPGAAT----AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 263 GYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLtiqLFAGLGLLVGWMLDiGLWGIVPFVMLFIGTLSTIGSNSMALL 342
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF---ALMALGFLLLALAS-GLWVVLLGAILAGLGFGLLLPTLNSWA 311
|
....*
gi 914654497 343 LSGYP 347
Cdd:cd17473 312 MSLVP 316
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
26-377 |
2.22e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 73.77 E-value: 2.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 26 LGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSAT 105
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 106 THGIEALTYIRTaQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFA 185
Cdd:cd17504 81 APNLPVLIAGRA-LQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 186 VIVILAVSMKIPETLpaenrqplrfkttiRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYidiYGVRPDLFGYL 265
Cdd:cd17504 160 VLLAALVPLIDLRLL--------------RRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTG---FGLGITEAGLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 266 FGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMALLLSg 345
Cdd:cd17504 223 LLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVP- 301
|
330 340 350
....*....|....*....|....*....|..
gi 914654497 346 yPNMAGTASSLAGTLRFGTGSVVGAIVAMLPS 377
Cdd:cd17504 302 -PDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
43-205 |
3.31e-14 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 73.95 E-value: 3.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFA 122
Cdd:TIGR00711 24 AIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPETLPA 202
Cdd:TIGR00711 104 GGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPA 183
|
...
gi 914654497 203 ENR 205
Cdd:TIGR00711 184 ASE 186
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-360 |
4.31e-13 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 70.27 E-value: 4.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 15 TPQLGLVLFLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVF 94
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 95 LFAIASMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFdREDFARTMSFVTLVMTVAPLVAPMIGGYLALW--- 171
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 172 FGWRSIFWVLAIFAVIVILAVSMKipeTLPAENRQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVY 251
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRS---KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 252 IDIYGVRPDLFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLtiqLFAGLGLLVGWMLDIGLWGIVPFVMLFIGtL 331
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSA---LLAAVGLLLALLAPGPWLALIGLALVGLG-L 313
|
330 340
....*....|....*....|....*....
gi 914654497 332 STIGSNSMALLLSGYPNMAGTASSLAGTL 360
Cdd:COG0738 314 SLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
39-382 |
2.80e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 2.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 39 MYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTA 118
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 119 QGFAGAAAAVIIQAVVR-----DMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAI-FAVIVILAV 192
Cdd:cd06173 97 VLAFLLGIASAFFGPARqallpELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALsFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 193 SMKIPETLPAENRQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVA 272
Cdd:cd06173 177 FIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 273 MILMTSINGRIVKKVGSHAMLRVGLTiqLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMaLLLSGYPNMAGT 352
Cdd:cd06173 257 ALLGALLLGRLSKRRRRGRLLLIGAL--LLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTL-LQLRVPDELRGR 333
|
330 340 350
....*....|....*....|....*....|
gi 914654497 353 ASSLAGTLrFGTGSVVGAIVAMLPSDTAGP 382
Cdd:cd06173 334 VFSVYNAL-NSGAMPLGALLAGLLADALGL 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
45-192 |
7.88e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.91 E-value: 7.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 45 PTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAGA 124
Cdd:cd17365 23 PALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 914654497 125 AAAVIIQAVVRDMFDRedfARTMSFVTLVMTVAPLVApMIGGYLALW----FGWRSIFWVLAIFAVIVILAV 192
Cdd:cd17365 103 AAMPNAITLVSEYAPA---RRRSLAVTLMFCGYPLGA-ALGGFLAAAlipaFGWRSVFLLGGVPPLILLPLL 170
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
43-200 |
9.92e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 59.51 E-value: 9.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFA 122
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPETL 200
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQVW 182
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
28-373 |
1.09e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 59.51 E-value: 1.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 28 AIGALTPLAIDMYLPAMPTIAKDLgVTAGEVQITLTAYTAGFALGQLLHGP----LADSYGRKPVLLIGVFLFAIASMVS 103
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREF-NKLGASGYYVGLLQSSYSLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 104 ATTHGIEALtYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAI 183
Cdd:cd17330 82 GLSRNLWLL-FLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 184 FAVIVILAVSMKIpetlpaenrqplrfkttirnyarlcknPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFG 263
Cdd:cd17330 161 LALLNLVLVLFFL---------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 264 YLFGLNIVAMILM-TSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIvpfVMLFIGTLSTIGSNSMALL 342
Cdd:cd17330 214 LLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAA---AILAFGTGIVFPALSALLS 290
|
330 340 350
....*....|....*....|....*....|.
gi 914654497 343 LSGYPNMAGTASSLAGTLRfGTGSVVGAIVA 373
Cdd:cd17330 291 KSVPSKEQGKAQGIIQSLQ-SLARIIGPLLA 320
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
43-200 |
1.11e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 59.68 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFA 122
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPETL 200
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESI 196
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
43-371 |
1.75e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 58.73 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGvTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFA 122
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWV-LAIFAVIVILavsmkipetlp 201
Cdd:cd17502 97 GGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInLPIGGLALAL----------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 202 aenrqplrfkttIRNYARLCknptAMGLIFSGAfsfsgMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTSING 281
Cdd:cd17502 166 ------------LRTILLSS----IFGFLFGGA-----LFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 282 RIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLF-IGTLSTIGSNSMALLLSGYPNMAGTASSLAGTL 360
Cdd:cd17502 225 ALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLgLGLGIGFQQPLVAVQNAVPPADVGVATATNTFF 304
|
330
....*....|.
gi 914654497 361 RFGTGSVVGAI 371
Cdd:cd17502 305 RSLGGTLGVAI 315
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
144-342 |
2.47e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.76 E-value: 2.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 144 ARTMSFVTLVMTVAPLVAPMIGGYLALWF------GWRSIFWVLAIFAVIVILAVSMKIPETlPAENRQPLRFKTTIRNy 217
Cdd:COG2211 146 TRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKER-PVPEEEKVSLKESLKA- 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 218 arLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGL 297
Cdd:COG2211 224 --LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 914654497 298 tiqLFAGLGLLVGWMLDIG-LWGIVPFVMLFIGTLSTIGSNSMALL 342
Cdd:COG2211 302 ---LLAALGLLLLFFLGPGnLWLLLVLAALAGIGLGAILVLPWAML 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-196 |
5.34e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 5.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 22 LFLILGAIGALTPLAIDMYLPAMPTIAKDL-GVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIAS 100
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 101 MVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWV 180
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 914654497 181 LAIFAVIVILAVSMKI 196
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
19-375 |
1.34e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.42 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 19 GLVLFLILGAIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAI 98
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 99 ASMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREdFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIF 178
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 179 WVLAIFAVIVILAVSMKIPETLPAENRQPLRFKTtirnyARLCKNPTAMGL-IFSGAFS--FSGMFAFLTAgsfVYIDiY 255
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRPAAAAAAPAAASL-----RSLWRSPLAWLLtLFFGLQSllYYAVVAWLPP---ILRD-A 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 256 GVRPDLFGYLFGLNIVAMILMTSINGRIVKKVGS-HAMLRVGLTIQLFAGLGLLVGW---------MLDIGLWGIVPFVM 325
Cdd:COG2807 246 GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDrRPLLLLLGLLGLAGLLGLLLAPgslpwlwavLLGLGQGGLFPLAL 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 914654497 326 LFIGTLStiGSNSMALLLSGYPNMAGTASSLAGTLRFG-----TGSVVGAIVAML 375
Cdd:COG2807 326 TLIGLRA--RTPAEAAALSGMAQSVGYLLAALGPLLVGalhdaTGSWTAALLLLA 378
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
28-344 |
3.54e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 54.95 E-value: 3.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 28 AIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGP----LADSYGRKPVLLIGVFLFAIASMVS 103
Cdd:cd17388 6 VTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAGAALDYLLM 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 104 ATTHGIEALtYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALwFGWRSIFWVLAI 183
Cdd:cd17388 86 AFAPTLWWL-YLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVAAG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 184 FAVIVILAVSMKIPETLPAENRQPLRFKT--TIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDL 261
Cdd:cd17388 164 LNGLNFLLGLFVLPESLPPERRRAFRWRRanPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTM 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 262 FGY-LFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLV---GWMLdiglwgivpFVMLFIGTLSTIGSN 337
Cdd:cd17388 244 VGLsLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFatqGWMV---------FPILILLALGGIAGP 314
|
....*..
gi 914654497 338 SMALLLS 344
Cdd:cd17388 315 ALQGLLS 321
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
39-199 |
4.75e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 54.62 E-value: 4.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 39 MYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTA 118
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 119 QGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTV----APLVAPMIGGYLALWFGWRSIFWvLAIFAVIVILAVSM 194
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVgwllATLLAALLFPLLPPEIAWRVLFL-LGALPALLVLFIRR 175
|
....*
gi 914654497 195 KIPET 199
Cdd:cd17371 176 FVKEP 180
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
28-397 |
8.83e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 8.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 28 AIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTH 107
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 108 GIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALwFGWRsIFWVLAIFAVI 187
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT-AGAL-PFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 188 VILAVSMKIPETLPAENRQPLRFKTTIRnyarlcKNPTAMGLIFSGAFSFSGMFAFLTagsfvyidIYGVRPDLF----G 263
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLLR------IAPLALLGAFVAGFLEGAFYSLLP--------LYGLRLGLSvaqaA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 264 YLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGsnsMALLL 343
Cdd:cd17477 227 LLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLA---LALAG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 914654497 344 SGYPNMAGTASSLAGTLRFGTGSVVGAIVAMLPSDTAGPMAMMMAACAILSALL 397
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFL 357
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
35-375 |
1.11e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 53.33 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 35 LAIDMY----LPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIE 110
Cdd:cd17478 6 FLNDFYqgflPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 111 ALTYIRTAQGFAGAAAAVIIQAVVRdMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVIL 190
Cdd:cd17478 86 LLLLLVALAGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 191 AVSMKIPetLPAENRQPLRFKTTIRNYARLCKNPTAM--GLIFSGAFSFSGMFAFLTagsfVYIDIYGVRPDLFGYLFGL 268
Cdd:cd17478 165 LLLRLRP--LKKPEAKKAAAKSSARSTLKGVWRALLLllIIVFLRSWVLSSLTTFLP----FYLVQRGYSLVFAGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 269 NIVAMILMTSINGRIVKKVGSHAMLRVGltiqlFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMALLLSGYPN 348
Cdd:cd17478 239 FLFAGAIGTLIGGPLSDRFGRRRVIIAS-----LLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPG 313
|
330 340
....*....|....*....|....*..
gi 914654497 349 MAGTASSLAGTLRFGTGSVVGAIVAML 375
Cdd:cd17478 314 NVGLASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
26-375 |
1.14e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 53.32 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 26 LGAIGALTPLAIDMYLPAMPT-IAKDLGVTAGEVQITLTAYT-AGFALGQLLhGPLADS-YGRKPVLLIGVFLFAIASMV 102
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSAlSGIVVSQWL-GRLSDRgGDRKPLILLALLAGALGYLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 103 SATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFART---MSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFW 179
Cdd:cd17471 80 FAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRSSGRDAtlfNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 180 VLAIFAVIVILAVSMKIPE-TLPAENRQPLRFKTTIRnyarlcKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVR 258
Cdd:cd17471 160 LAALLYLVVALLVLFLLPSvKPPAQKATPASSLVKAP------VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 259 PDLFGYLFGLN----IVAMILMtsinGRIVKKVGSHAMLRVGLTiqlfAGLGLLVGWMLDIGLWGIVPFVML---FIGTL 331
Cdd:cd17471 234 ESWVGLLFGLAaaleIPIMLLA----GLLAKRFGKRRLLLAGFL----AGVLFYLGLALATSLWQLIALQLLnaiFIGIT 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 914654497 332 STIGSNSMALLLsgyPNMAGTASSLagtlrFGTGSVVGAIVAML 375
Cdd:cd17471 306 AGLGISYFQDLM---PGQPGLATTL-----YSNASRIGSLLGGL 341
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-199 |
2.31e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.18 E-value: 2.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 18 LGLVLFLILGAIGALTPLAIDMYLPAMPTIAKD-LGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGR--KPVLLIGVF 94
Cdd:COG2271 177 LALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 95 LFAIASMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGW 174
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
170 180
....*....|....*....|....*
gi 914654497 175 RSIFWVLAIFAVIVILAVSMKIPET 199
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRET 361
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
40-249 |
5.73e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.07 E-value: 5.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 40 YLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYG-RKPVLLIGVFLFAIASMVSATTHGIEALtYIRTA 118
Cdd:cd17490 15 YVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGL-LIARF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 119 QGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAvSMKIPE 198
Cdd:cd17490 94 LSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFIL-SLFIKE 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 914654497 199 tlpaENRQPLRFKTTIRNYARLCKNP----------TAMGLIFSGAFSFSGMFAF-LTAGSF 249
Cdd:cd17490 173 ----ERREKKPVLTELKELLSVLKDKkllffsllaiLQQMITFSTTFGFTPLIAKqLGASSF 230
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
26-373 |
6.40e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 51.06 E-value: 6.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 26 LGAIGALTPLAIDMYLPAMPTIAKDL-GVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSA 104
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 105 TTHGIEALTYIRtaQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIF 184
Cdd:cd17472 81 YATSIYGLILGR--ALQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 185 AVIVILAVSMKIPEtlpaENRQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGY 264
Cdd:cd17472 159 SLVSLLILLFFVPD----PPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 265 LFGLNIVAMILMtSINGRIVKKVGShaMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIgtlstIGSNSMALLLS 344
Cdd:cd17472 235 YLPAILIGFILM-VPFVIYAEKKGK--MKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFF-----IGFNLLEALLP 306
|
330 340 350
....*....|....*....|....*....|....*
gi 914654497 345 GY------PNMAGTASSLAGTLRFgTGSVVGAIVA 373
Cdd:cd17472 307 SLvskiapKEYRGTAMGIYNTSQF-LGSFLGGALG 340
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
42-188 |
2.61e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.19 E-value: 2.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 42 PAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGF 121
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 914654497 122 AGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIV 188
Cdd:cd17312 104 FQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVV 170
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
47-327 |
3.07e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.76 E-value: 3.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 47 IAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAGAAA 126
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 127 AVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALwFGWRSIFWVLAIFAVIVILAVSMKIPETLPAenRQ 206
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPK--RR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 207 PLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTSINGRIVKK 286
Cdd:cd17329 183 AAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVER 262
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 914654497 287 VGSHAMLRVGLtiqLFAGLGLLVGWMLdIGLWGIVPFVMLF 327
Cdd:cd17329 263 FRLRKILMIGI---LLFAIGFAVLAFA-NTLAVLILAMIVL 299
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
43-197 |
3.38e-06 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 48.96 E-value: 3.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFA 122
Cdd:PRK10504 32 ALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIP 197
Cdd:PRK10504 112 GAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMP 186
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
43-375 |
4.34e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.53 E-value: 4.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFA 122
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVA-PLVAPMIGGYLALWFGWRSIFWVLAIFAVIVIL---------AV 192
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLicflllrdsPQ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 193 SMKIPETLPAENRQPLRFKTTIRNYAR--------LCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGY 264
Cdd:TIGR00881 177 SCGLPPAEEMPNEEPDGDAEKKEEELTkkqiflqyVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 265 LFGLNIVAMILMTSINGRIVKK--VGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFV---MLFIGTLSTIGSNSM 339
Cdd:TIGR00881 257 AFTLYELGGLVGTLLAGWLSDKlfNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFalgFLVYGPQMLIGVIAS 336
|
330 340 350
....*....|....*....|....*....|....*.
gi 914654497 340 ALllsGYPNMAGTASSLAGTLRFGTGSVVGAIVAML 375
Cdd:TIGR00881 337 EL---APKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
44-329 |
5.02e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 48.09 E-value: 5.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 44 MPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAG 123
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 124 AAAAVIIQAVVRDMFDrEDFARTMSFVTLVMTVAPLVAPMIGGYLALW-FGWRSIFWVLAIFAVIVILAVSM-KIPETLP 201
Cdd:cd17333 99 GILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLIYLLLAILILLtLFPELPS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 202 AENRQ--PLRFKTTIRNYARLCknptamGLIFSGAFSFSGMFAFLTAGSFVY---IDIYGVRPDLFGYLFGLNIVAMILM 276
Cdd:cd17333 178 ARNPQqsVGAFSASASRLLRNP------SIILGALALFLYVGAETAFSSWVPsylVEKKHVSDGLAGYLLSGFWVGITIG 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 914654497 277 TSINGRIVKKVGSHAMLRVGLTIqlfAGLGLLVGWMLDIGLWGIVPFVMLFIG 329
Cdd:cd17333 252 RLLGGPISRRIKPHTLLVLSGSG---ALLGLLILLLAPTLVVGLVATALLGLF 301
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
43-192 |
5.92e-06 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 48.51 E-value: 5.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITlTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATThgiealTYIRTAQGFA 122
Cdd:pfam06609 66 ALPNILQDIGQSENQGLFS-TLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTA------NKFNTLLAAM 138
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVA-----PMIGGYLALWFGWRSIFWVLAIFAVIVILAV 192
Cdd:pfam06609 139 TLLGVAAGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAmngagPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLI 213
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
32-201 |
2.93e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 45.72 E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 32 LTPLAIDMYLPAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEA 111
Cdd:cd17476 9 LNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 112 LTYIRTAQGFAGAAAAVIIQAVVRDMFdREDFARTMSFVTLVMTvAPL---VAPMIGGYLALWFGWRSIFWVLAIFAVIV 188
Cdd:cd17476 89 FIICRALQGLGPAFLLPNAMALLGRTY-PPGPRKNIVFSLFGAT-APLgfaLGGVFGGLFAQLAWWPWIFWFLAILAAIV 166
|
170
....*....|....
gi 914654497 189 -ILAVSMKIPETLP 201
Cdd:cd17476 167 aVAAIFWTSPSFIA 180
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
45-362 |
3.64e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 45.69 E-value: 3.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 45 PTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAGA 124
Cdd:cd17475 20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 125 AAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPETlPAEN 204
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP-PAAS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 205 RQPLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTSINGRIV 284
Cdd:cd17475 179 AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 285 KKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIG--LWGIVPFVMLFigTLSTIGSNSMALLL---SGYPNMAGTASSLAGT 359
Cdd:cd17475 259 DRVFGGRRRPVLVITAAIAAAALLVLSLLSPGtpLWLLVLLLILL--GLFAIGWNGLYLTLvaeSAGPEQAGTALGLANT 336
|
...
gi 914654497 360 LRF 362
Cdd:cd17475 337 INF 339
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
44-199 |
3.98e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 45.69 E-value: 3.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 44 MPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAG 123
Cdd:PRK12307 41 MYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGM 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 914654497 124 AAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVlAIFAVIVILAVSMKIPET 199
Cdd:PRK12307 121 AGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV-GLLPVLLVIYIRARAPES 195
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-375 |
8.87e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 8.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 23 FLILGAIGALTPLAIDMYLPAMPTIAK--DLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIAS 100
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 101 MVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDRED----FARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRS 176
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRrgfaLGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 177 IFWVLAIFAVIVILavsmkipetlpaenrqpLRFKTTIrnyarlcknptAMGLIFSGAFSFSGMFAFLTAgsfVYIDIYG 256
Cdd:cd17316 161 LFLIGALPALLALL-----------------LRRRTLL-----------LILLWFFISFGYYGLTTFLPT---YLQTVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 257 VRPDLFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTiqLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGS 336
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLI--LSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWG 287
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 914654497 337 NSMALLLSGYP-NMAGTASSLAGTLRFGTGSVVGAIVAML 375
Cdd:cd17316 288 ALYAYLAELFPtEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
32-192 |
1.20e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 32 LTPLAIDMYLPAMPTIAKDLGVTAGE-------VQITLTAYTAGFAlgQLLHGPLADSYGRKPVLLIGVFLFAIASMVSA 104
Cdd:cd17391 7 FTGIGFSLIAPFLPLYIEQLGVTSGGlvelwsgLAFSSTFLVSAIF--SPIWGRLADRYGRKPMLLRASLGMAIVIGLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 105 TTHGIEALTYIRtAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIF 184
Cdd:cd17391 85 FVTNVWQLLILR-LLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGL 163
|
....*...
gi 914654497 185 AVIVILAV 192
Cdd:cd17391 164 LFLAFLLT 171
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
43-199 |
2.03e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.93 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVS--ATTHGIEALTYIRTAQG 120
Cdd:cd17380 21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTplLAYSSLPLLILSRILLG 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 914654497 121 FAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPET 199
Cdd:cd17380 101 LGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLPPV 179
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
43-112 |
3.31e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 42.64 E-value: 3.31e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 914654497 43 AMPTIAKDLGV---TAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEAL 112
Cdd:cd17360 19 ALLYIKDDLGEvvlSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVL 91
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-329 |
3.70e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 3.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 18 LGLVLFLILGAIGALTPLAIDMYLPamptIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFA 97
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIP----IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 98 IASMVSATTHGIEAL--TYIRTAQGFAGAAAAVIIQAVVRDMFDREDfARTMSFVTLVMTVAPLVAPMIGGYLALWFGWR 175
Cdd:cd17355 80 AGLVLLALATSLWQLylLWGLLGGGGAGTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 176 SIFWVLAIFAVIVILAV---SMKIPETLPAENRQPLRFKTTIRNYARLCKNPTamGLIFSGAFSFSGM-FAFLTAGSFVY 251
Cdd:cd17355 159 TALLVLALLALLVLVPVlllLRRRPADLALRAYDDASPASPGSTLKEALRSAS--FWLLALAFFLCGFaVVGLIVHLVPY 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 914654497 252 IDIYGVRPDLFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIG 329
Cdd:cd17355 237 LADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWG 314
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
135-343 |
4.94e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 41.91 E-value: 4.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 135 RDMFDREDFARTMSFVT-----LVMTVAPLVAPMIGGYLAL---WFGWRSIFWVLAIFAVIVILAVSMKIPETLPAENRQ 206
Cdd:pfam13347 127 RDYDERTSLTSYRSFFSvggglLAAALAFPLVLILGGTGLErkgYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTG 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 207 PLRFKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGvRPDLFGYLFGLNIVAMILMTSINGRIVKK 286
Cdd:pfam13347 207 QKEAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLG-NGFAASAFPLVFTIGALLGIPLWPPLAKR 285
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 914654497 287 VGSHAMLRVGLTIQLFaglGLLVGWMLDIGLWGIVpFVMLFIGTLSTIGSNSMALLL 343
Cdd:pfam13347 286 IGKKNTYILGALITIA---GFALALLLGPNNTLLF-LVLYIIIGFGYGSSFFLPWSM 338
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
31-104 |
8.47e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.54 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 31 ALTPLAIDMYLPAMPTIAKDLGV-------TAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVS 103
Cdd:TIGR00898 95 AATEPCLDGWEYSYDTFSSTIVTewdlvceDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLT 174
|
.
gi 914654497 104 A 104
Cdd:TIGR00898 175 A 175
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
34-210 |
9.35e-04 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 41.25 E-value: 9.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 34 PLAIDMYL--PAMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEA 111
Cdd:PRK14995 17 PVAIDATVlhVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASW 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 112 LTYIRTAQGFAGAAAAVIIQAVVRDMF-DREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFwVLAIFAVIVIL 190
Cdd:PRK14995 97 LIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVF-LINVPIVLVVM 175
|
170 180
....*....|....*....|
gi 914654497 191 AVSMKIPETLPAENRQPLRF 210
Cdd:PRK14995 176 GLTARYVPRQAGRRDQPLNL 195
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
28-187 |
1.08e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.07 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 28 AIGALTPLAIDMYLPAMPTIAKDLGVTAGEVQITL---TAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSA 104
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTwisTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 105 TTHGIEALTyIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLAL--WFGWRSIFWVLA 182
Cdd:cd06179 81 TAKSVNMLI-GGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYINA 159
|
....*
gi 914654497 183 IFAVI 187
Cdd:cd06179 160 IFNAL 164
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
43-199 |
1.10e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.10 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFA 122
Cdd:PRK11551 37 AAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVG 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 914654497 123 GAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPET 199
Cdd:PRK11551 117 LGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPES 193
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
47-286 |
1.20e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 40.67 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 47 IAKDLGVTAGEV--QITLTAYTAGFAlgQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAGA 124
Cdd:PRK10213 46 MAQDLGISEGVAgqSVTVTAFVAMFA--SLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 125 AAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPeTLPAEn 204
Cdd:PRK10213 124 GFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWIIKSLP-SLPGE- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 205 rqPLRFKttiRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTSINGRIV 284
Cdd:PRK10213 202 --PSHQK---QNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSLSSFIL 276
|
..
gi 914654497 285 KK 286
Cdd:PRK10213 277 KR 278
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
66-378 |
2.04e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 39.91 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 66 TAGFALGQLLHGP----LADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDRE 141
Cdd:cd17328 40 QTVFIISYMVLSPifgyLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 142 DFARTMSFVTLVMTVAPLVAPMIGGYLA-LWFGWRSIFWVLAIFAVIVILAVSMKIPETLPAENRQPLRFKTTIRNYAR- 219
Cdd:cd17328 120 KRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAd 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 220 ---LCKNPTAMGLIFSGAF-SFSGMFAFLTAGSFVYIdIYGVRPD-------LFGYLFGLNIVAMILMTSINGRIVKKVG 288
Cdd:cd17328 200 lkaLAKNPSFILSTLGFTAvSFVTGALAFWAPTFFLR-AFGVGDLssadvglIFGAITCIAGVLGVLLGGILADRLRRKT 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 289 SHAMLRVGLTIQLFAGLGLLVGwMLDIGLWGIVPFVMLFIGTL---STIGSNSMALLLSGYPNMAGTASSLAGTLRFGTG 365
Cdd:cd17328 279 PRADPLVCAVGLLAAAPFLFLA-LVLALSNLLLAWVLLFLGEFllsLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLG 357
|
330
....*....|...
gi 914654497 366 SVVGAIVAMLPSD 378
Cdd:cd17328 358 DAGSPYLIGLISD 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
23-192 |
2.14e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 23 FLILGAIGALTPLAIDMYLPAMPTIAKD-LGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIAS- 100
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLl 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 101 MVSATTHGIEALTYIRTAQGFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFG-WRSIFW 179
Cdd:COG2223 287 LLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFL 366
|
170
....*....|...
gi 914654497 180 VLAIFAVIVILAV 192
Cdd:COG2223 367 VFAVLALVALVLT 379
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
44-376 |
3.62e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 39.31 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 44 MPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQGFAG 123
Cdd:PRK10091 26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPH 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 124 AAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWRSIFWVLAIFAVIVILAVSMKIPeTLPAE 203
Cdd:PRK10091 106 GAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVP-DIRDE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 204 NrqplrfKTTIRNYARLCKNPTAMGLIFSGAFSFSGMFAFLTAGSFVYIDIYGVRPDLFGYLFGLNIVAMILMTSINGRI 283
Cdd:PRK10091 185 A------KGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMMLVGLGMVLGNLLSGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 284 vkkVGSHAMLRVGLTIQLFAGLGLLVGWMLDIGLWGIVPFVMLFIGTLSTIGSNSMALLL--SGYPNMAGTASslaGTLR 361
Cdd:PRK10091 259 ---SGRYSPLRIAAVTDFIIVLALLMLFFFGGMKTASLIFAFICCAGLFALSAPLQILLLqnAKGGELLGAAG---GQIA 332
|
330
....*....|....*
gi 914654497 362 FGTGSVVGAIVAMLP 376
Cdd:PRK10091 333 FNLGSAIGAYCGGMM 347
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
58-104 |
4.51e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 4.51e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 914654497 58 VQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSA 104
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSA 73
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
43-104 |
6.31e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.32 E-value: 6.31e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 914654497 43 AMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSA 104
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
42-201 |
8.17e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 37.94 E-value: 8.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 42 PAMPTIAKDLGVTAGEVQITL--TAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEALTYIRTAQ 119
Cdd:cd17315 18 GALLYIAKDLGFGLSTSLQGLvvSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 120 GFAGAAAAVIIQAVVRDMFDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWF--GWRSIFWVLAIFAVIVILAVSMkIP 197
Cdd:cd17315 98 GLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpgWWRLMFALAAVPALLQLLLMFF-LP 176
|
....
gi 914654497 198 ETLP 201
Cdd:cd17315 177 ESRA 180
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
20-373 |
9.73e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 37.95 E-value: 9.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 20 LVLFLILGAIGALTPLaidmylpaMPTIAKDLGVTAGEVQITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIA 99
Cdd:cd17335 4 LFYFFFFAALGSLLPF--------LSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 100 SMVSATTHGIEALTY--IRTAQGFAGAAAAVIIQAVVRDM--FDREDFARTMSFVTLVMTVAPLVAPMIGGYLALWFGWR 175
Cdd:cd17335 76 FFLSLFFVAQIFWLLllLVILGAFFSAPVVPLVDSITLQYlgEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNYT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 176 SIFWVLAIFAVIVILAVSM-KIPETLPAENrqplrfkTTIRNYARLCKNPTAMGLIFSGAFSFSGMfAFLTAGSFVYIDI 254
Cdd:cd17335 156 IAFYVFAVLMLLALLLALKfPFRPKHPEPN-------ENTGGLLALLRNPRVLAFLLVAFLMGFGH-GLIYSFLFWHLQD 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914654497 255 YGVRPDLFGYLFGLNIVAMILMTSINGRIVKKVGSHAMLRVGLTIqlFAGLGLLVGWMLDigLWGIVPFVMLFIGTLSTI 334
Cdd:cd17335 228 LGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLA--YVVRWLLYSFLEN--PWLVLPIELLHGLTFALV 303
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 914654497 335 GSNSMALL-LSGYPNMAGTASSLAGTLRFGTGSVVGAIVA 373
Cdd:cd17335 304 WAAAVSYAsAAAPPGLRATAQGLLQGLYFGLGGGLGSLIG 343
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
60-112 |
9.83e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.02 E-value: 9.83e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 914654497 60 ITLTAYTAGFALGQLLHGPLADSYGRKPVLLIGVFLFAIASMVSATTHGIEAL 112
Cdd:pfam00083 50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSV 102
|
|
| |
