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Conserved domains on  [gi|915392941|ref|WP_050778326|]
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helix-turn-helix transcriptional regulator [Marvinbryantia formatexigens]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10787697)

helix-turn-helix (HTH) transcriptional regulator containing a XRE (Xenobiotic Response Element) family HTH domain may act as a transcriptional regulator that controls the expression of genes involved in stress response

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  10473770|2644244
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
14-76 1.49e-09

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


:

Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 48.69  E-value: 1.49e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 915392941 14 NLKIVRIKKGMKQSDLSAASGVPVKCIGNYEQLRRNINharVDIVYRLAIALDCKIEDILELN 76
Cdd:COG1476   8 RLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPS---LELALKIARALGVSLEELFSLE 67
 
Name Accession Description Interval E-value
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
14-76 1.49e-09

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 48.69  E-value: 1.49e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 915392941 14 NLKIVRIKKGMKQSDLSAASGVPVKCIGNYEQLRRNINharVDIVYRLAIALDCKIEDILELN 76
Cdd:COG1476   8 RLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPS---LELALKIARALGVSLEELFSLE 67
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-72 5.71e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 41.73  E-value: 5.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 915392941   14 NLKIVRIKKGMKQSDLSAASGVPVKCIGNYEQLRRNINharVDIVYRLAIALDCKIEDI 72
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPS---LETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 13-72 1.15e-06

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.38  E-value: 1.15e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 915392941 13 SNLKIVRIKKGMKQSDLSAASGVPVKCIGNYEQLRRNINharVDIVYRLAIALDCKIEDI 72
Cdd:cd00093   2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPS---LETLEKLAKALGVSLDEL 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 15-72 4.07e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 39.83  E-value: 4.07e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 915392941  15 LKIVRIKKGMKQSDLSAASGVPVKCIGNYEqlrRNINHARVDIVYRLAIALDCKIEDI 72
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIE---NGKREPSLETLKKLAEALGVSLDEL 55
 
Name Accession Description Interval E-value
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
14-76 1.49e-09

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 48.69  E-value: 1.49e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 915392941 14 NLKIVRIKKGMKQSDLSAASGVPVKCIGNYEQLRRNINharVDIVYRLAIALDCKIEDILELN 76
Cdd:COG1476   8 RLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPS---LELALKIARALGVSLEELFSLE 67
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
14-74 1.24e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 46.91  E-value: 1.24e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 915392941 14 NLKIVRIKKGMKQSDLSAASGVPVKCIGNYEQLRRNINharVDIVYRLAIALDCKIEDILE 74
Cdd:COG1396  11 RLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPS---LETLLKLAKALGVSLDELLG 68
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
12-74 2.80e-07

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 42.82  E-value: 2.80e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 915392941 12 ISNLKIVRIKKGMKQSDLSAASGVPVKCIGNyeqLRRN-INHARVDIVYRLAIALDCKIEDILE 74
Cdd:COG3655   3 YVKLDELLAERGMTKKELAEATGISRATLSR---LKNGkAKAVRLDTLEKICKALDCQPGDLLE 63
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-72 5.71e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 41.73  E-value: 5.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 915392941   14 NLKIVRIKKGMKQSDLSAASGVPVKCIGNYEQLRRNINharVDIVYRLAIALDCKIEDI 72
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPS---LETLKKLAKALGVSLDEL 56
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 13-72 1.15e-06

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.38  E-value: 1.15e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 915392941 13 SNLKIVRIKKGMKQSDLSAASGVPVKCIGNYEQLRRNINharVDIVYRLAIALDCKIEDI 72
Cdd:cd00093   2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPS---LETLEKLAKALGVSLDEL 58
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 15-72 4.07e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 39.83  E-value: 4.07e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 915392941  15 LKIVRIKKGMKQSDLSAASGVPVKCIGNYEqlrRNINHARVDIVYRLAIALDCKIEDI 72
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIE---NGKREPSLETLKKLAEALGVSLDEL 55
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 14-76 1.58e-05

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 38.29  E-value: 1.58e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 915392941  14 NLKIVRIKKGMKQSDLSAASGVPVKCIGNYeqLRRNINHARVDIVYRLAIALDCKIEDILELN 76
Cdd:pfam13443  1 KLRKLMADRGISKSDLARATGISRATLSRL--RKGKPKRVSLDTLDKICDALGCQPGDLLEYV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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