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Conserved domains on  [gi|916024266|ref|WP_050949861|]
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epoxide hydrolase family protein [Gordonia effusa]

Protein Classification

epoxide hydrolase family protein( domain architecture ID 12070441)

epoxide hydrolase family protein may catalyze the conversion of epoxides to trans-dihydrodiols, thus preventing or reducing their reaction with cellular macromolecules such as protein or DNA

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19469578|12369917|19508187|37582413|31545554
SCOP:  4000716

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
EHN pfam06441
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ...
 14-103 1.75e-39

Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.


:

Pssm-ID: 461913  Cd Length: 106  Bit Score: 136.06  E-value: 1.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266   14 RRRSKRPVYRPAPDPRRWDQGVPRADLADIVNYWRTGYDWRLFETRLNEIGQFRTTIDGLGIHFLHRRSTRADATPLILT 93
Cdd:pfam06441  17 RQRLALTRWPDELEGDDWWYGVPLDYLRELVDYWRDGYDWRAQEARLNSFPQFTTEIDGLDIHFVHVRSNKPDAIPLLLL 96

                          90
                  ....*....|
gi 916024266   94 HGWPGSIAEF 103
Cdd:pfam06441  97 HGWPGSFLEF 106
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 65-227 1.25e-22

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 94.68  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  65 QFRTTIDGLGIHFlhrRSTRADATPLILTHGWPGSIAEFIDVIAELtepkdagAPAFHVVVPSLPGFGYSDKPTStGWGT 144
Cdd:COG0596    4 PRFVTVDGVRLHY---REAGPDGPPVVLLHGLPGSSYEWRPLIPAL-------AAGYRVIAPDLRGHGRSDKPAG-GYTL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266 145 EKIAAAWVKLMERLGYRRFLAHGGDWGGVITTILAGRFPTHVLGIHsalaqappgLTTDGLTPIERRWTEETRDFWRLRA 224
Cdd:COG0596   73 DDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLV---------LVDEVLAALAEPLRRPGLAPEALAA 143


                 ...
gi 916024266 225 AYA 227
Cdd:COG0596  144 LLR 146
 
Name Accession Description Interval E-value
EHN pfam06441
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ...
 14-103 1.75e-39

Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.


Pssm-ID: 461913  Cd Length: 106  Bit Score: 136.06  E-value: 1.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266   14 RRRSKRPVYRPAPDPRRWDQGVPRADLADIVNYWRTGYDWRLFETRLNEIGQFRTTIDGLGIHFLHRRSTRADATPLILT 93
Cdd:pfam06441  17 RQRLALTRWPDELEGDDWWYGVPLDYLRELVDYWRDGYDWRAQEARLNSFPQFTTEIDGLDIHFVHVRSNKPDAIPLLLL 96

                          90
                  ....*....|
gi 916024266   94 HGWPGSIAEF 103
Cdd:pfam06441  97 HGWPGSFLEF 106
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 65-227 1.25e-22

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 94.68  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  65 QFRTTIDGLGIHFlhrRSTRADATPLILTHGWPGSIAEFIDVIAELtepkdagAPAFHVVVPSLPGFGYSDKPTStGWGT 144
Cdd:COG0596    4 PRFVTVDGVRLHY---REAGPDGPPVVLLHGLPGSSYEWRPLIPAL-------AAGYRVIAPDLRGHGRSDKPAG-GYTL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266 145 EKIAAAWVKLMERLGYRRFLAHGGDWGGVITTILAGRFPTHVLGIHsalaqappgLTTDGLTPIERRWTEETRDFWRLRA 224
Cdd:COG0596   73 DDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLV---------LVDEVLAALAEPLRRPGLAPEALAA 143


                 ...
gi 916024266 225 AYA 227
Cdd:COG0596  144 LLR 146
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 88-203 5.30e-15

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 73.69  E-value: 5.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266   88 TPLILTHGWPGSIAEFIDVIAELTEPKdagapaFHVVVPSLPGFGYSDKPTS-TGWGTEKIAAAWVKLMERLGYRRFLAH 166
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDG------FRVIALDLRGFGKSSRPKAqDDYRTDDLAEDLEYILEALGLEKVNLV 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 916024266  167 GGDWGGVITTILAGRFPTHVLGIHSALAQAPPGLTTD 203
Cdd:pfam00561  75 GHSMGGLIALAYAAKYPDRVKALVLLGALDPPHELDE 111
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 85-183 3.02e-07

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 51.51  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  85 ADATPLILTHGWPGSIAEFIDVIAELTepkDAGapaFHVVVPSLPGFGYSDKPTSTGWGTEKIAAAWVK-LMERLGYRRF 163
Cdd:PRK00870  44 ADGPPVLLLHGEPSWSYLYRKMIPILA---AAG---HRVIAPDLIGFGRSDKPTRREDYTYARHVEWMRsWFEQLDLTDV 117

                         90       100
                 ....*....|....*....|
gi 916024266 164 LAHGGDWGGVITTILAGRFP 183
Cdd:PRK00870 118 TLVCQDWGGLIGLRLAAEHP 137
 
Name Accession Description Interval E-value
EHN pfam06441
Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic ...
 14-103 1.75e-39

Epoxide hydrolase N terminus; This family represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases (EC:3.3.2.3) comprise a group of functionally related enzymes that catalyze the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living organizms, including mammals, invertebrates, plants, fungi and bacteria. In animals, the major interest in EH is directed towards their detoxification capacity for epoxides since they are important safeguards against the cytotoxic and genotoxic potential of oxirane derivatives that are often reactive electrophiles because of the high tension of the three-membered ring system and the strong polarization of the C--O bonds. This is of significant relevance because epoxides are frequent intermediary metabolites which arise during the biotransformation of foreign compounds. This family is often found in conjunction with pfam00561.


Pssm-ID: 461913  Cd Length: 106  Bit Score: 136.06  E-value: 1.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266   14 RRRSKRPVYRPAPDPRRWDQGVPRADLADIVNYWRTGYDWRLFETRLNEIGQFRTTIDGLGIHFLHRRSTRADATPLILT 93
Cdd:pfam06441  17 RQRLALTRWPDELEGDDWWYGVPLDYLRELVDYWRDGYDWRAQEARLNSFPQFTTEIDGLDIHFVHVRSNKPDAIPLLLL 96

                          90
                  ....*....|
gi 916024266   94 HGWPGSIAEF 103
Cdd:pfam06441  97 HGWPGSFLEF 106
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 65-227 1.25e-22

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 94.68  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  65 QFRTTIDGLGIHFlhrRSTRADATPLILTHGWPGSIAEFIDVIAELtepkdagAPAFHVVVPSLPGFGYSDKPTStGWGT 144
Cdd:COG0596    4 PRFVTVDGVRLHY---REAGPDGPPVVLLHGLPGSSYEWRPLIPAL-------AAGYRVIAPDLRGHGRSDKPAG-GYTL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266 145 EKIAAAWVKLMERLGYRRFLAHGGDWGGVITTILAGRFPTHVLGIHsalaqappgLTTDGLTPIERRWTEETRDFWRLRA 224
Cdd:COG0596   73 DDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLV---------LVDEVLAALAEPLRRPGLAPEALAA 143


                 ...
gi 916024266 225 AYA 227
Cdd:COG0596  144 LLR 146
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 88-203 5.30e-15

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 73.69  E-value: 5.30e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266   88 TPLILTHGWPGSIAEFIDVIAELTEPKdagapaFHVVVPSLPGFGYSDKPTS-TGWGTEKIAAAWVKLMERLGYRRFLAH 166
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDG------FRVIALDLRGFGKSSRPKAqDDYRTDDLAEDLEYILEALGLEKVNLV 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 916024266  167 GGDWGGVITTILAGRFPTHVLGIHSALAQAPPGLTTD 203
Cdd:pfam00561  75 GHSMGGLIALAYAAKYPDRVKALVLLGALDPPHELDE 111
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
68-217 7.32e-08

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 52.70  E-value: 7.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  68 TTIDGLGIHFLHRRSTRADATPLILTHGWPGSIAEFIDVIAELTEpkdAGapaFHVVVPSLPGFGYSDKPTSTGWGTEKI 147
Cdd:COG2267    9 PTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAA---AG---YAVLAFDLRGHGRSDGPRGHVDSFDDY 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 916024266 148 AA---AWVKLMERLGYRRF--LAHGgdWGGVITTILAGRFPTHVlgihSALAQAPPGLTTDGLTPIERRWTEETR 217
Cdd:COG2267   83 VDdlrAALDALRARPGLPVvlLGHS--MGGLIALLYAARYPDRV----AGLVLLAPAYRADPLLGPSARWLRALR 151
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 85-183 3.02e-07

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 51.51  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  85 ADATPLILTHGWPGSIAEFIDVIAELTepkDAGapaFHVVVPSLPGFGYSDKPTSTGWGTEKIAAAWVK-LMERLGYRRF 163
Cdd:PRK00870  44 ADGPPVLLLHGEPSWSYLYRKMIPILA---AAG---HRVIAPDLIGFGRSDKPTRREDYTYARHVEWMRsWFEQLDLTDV 117

                         90       100
                 ....*....|....*....|
gi 916024266 164 LAHGGDWGGVITTILAGRFP 183
Cdd:PRK00870 118 TLVCQDWGGLIGLRLAAEHP 137
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 86-189 1.02e-05

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 46.77  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  86 DATPLILTHGWPGSIAEFIDVIAELTEpkdagapAFHVVVPSLPGFGYSDKPTSTGWGTEKIAAAWVKLMERLGYRRFLA 165
Cdd:PRK03204  33 TGPPILLCHGNPTWSFLYRDIIVALRD-------RFRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGLDRYLS 105

                         90       100
                 ....*....|....*....|....
gi 916024266 166 HGGDWGGVITTILAGRFPTHVLGI 189
Cdd:PRK03204 106 MGQDWGGPISMAVAVERADRVRGV 129
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 90-279 6.78e-05

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 43.62  E-value: 6.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266   90 LILTHGWPGSIAEFIDviaeltepkdAGAPAFHVVVPSLPGFGYSDKPTSTgWGTekiAAAWVKLMERLG-YRRFLAHGG 168
Cdd:pfam12697   1 VVLVHGAGLSAAPLAA----------LLAAGVAVLAPDLPGHGSSSPPPLD-LAD---LADLAALLDELGaARPVVLVGH 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  169 DWGGVITTILAGRFPthVLGIHSALAQAPPGLTTDGLTPIERRWTEETRDFWRLRAAYAK---QQATRPQTIGYSLVDSP 245
Cdd:pfam12697  67 SLGGAVALAAAAAAL--VVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARgflDDLPADAEWAAALARLA 144

                         170       180       190
                  ....*....|....*....|....*....|....
gi 916024266  246 VGLLAWILDKFAEWTDTDDSPFELISRDRILDDV 279
Cdd:pfam12697 145 ALLAALALLPLAAWRDLPVPVLVLAEEDRLVPEL 178
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
68-228 9.70e-04

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 40.39  E-value: 9.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  68 TTIDGLGIHFLHRRSTRADATPLIL-THGWPGSIAE-FIDVIAELTepkDAGapaFHVVVPSLPGFGYSDKPTSTGWGTE 145
Cdd:COG1506    3 KSADGTTLPGWLYLPADGKKYPVVVyVHGGPGSRDDsFLPLAQALA---SRG---YAVLAPDYRGYGESAGDWGGDEVDD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266 146 KIAAA-WVKLMERLGYRRFLAHGGDWGGVITTILAGRFPThvlGIHSALAQAPPGLTTDGLTPIERRWTEETRDFWRLRA 224
Cdd:COG1506   77 VLAAIdYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPD---RFKAAVALAGVSDLRSYYGTTREYTERLMGGPWEDPE 153


                 ....
gi 916024266 225 AYAK 228
Cdd:COG1506  154 AYAA 157
PRK05855 PRK05855
SDR family oxidoreductase;
65-173 9.03e-03

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 38.04  E-value: 9.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916024266  65 QFRTTIDGLGIHFlhRRSTRADATPLILTHGWPGSIAEFIDVIAELtepkdagAPAFHVVVPSLPGFGYSDKPTST-GWG 143
Cdd:PRK05855   5 RTVVSSDGVRLAV--YEWGDPDRPTVVLVHGYPDNHEVWDGVAPLL-------ADRFRVVAYDVRGAGRSSAPKRTaAYT 75

                         90       100       110
                 ....*....|....*....|....*....|...
gi 916024266 144 TEKIAAAWVKLMERLGYRR---FLAHggDWGGV 173
Cdd:PRK05855  76 LARLADDFAAVIDAVSPDRpvhLLAH--DWGSI 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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