|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-417 |
1.20e-77 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 245.17 E-value: 1.20e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 27 RWIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTI 106
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 107 GHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRW 186
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF--GWRW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 187 AFIVTGLFNVVWLGLWFWLYRKpadhprltpeerawietepsvdvgratfrsvlrhreTWAYMAGRFLIDPVWWTFLFWL 266
Cdd:cd17319 159 AFIIEGLLGLLLAVLWWFYLRQ------------------------------------VWGLALGYFGINYALYGLLTWL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 267 PDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLkrgvaTGRARKRAMFVCALFALPVMFAVQASNIWIAVAF 346
Cdd:cd17319 203 PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL-----RGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 916435700 347 IGLACAAHQGFSTNLFSLPGDLFPRYAQGTLVGLGGFAGAAGGFIASKSLGLLLDTVGSYQPFFIACGLAY 417
Cdd:cd17319 278 LSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVA 348
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-417 |
5.81e-62 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 204.72 E-value: 5.81e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 21 RPRGRVRWIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLA 100
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 101 VATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTF 180
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 181 alNWRWAFIVTGLFNVVWLGLWFWLyrkpadhprltpeerawietepsvdvgratfrsvlrhretwaYMAGRFLIDPVWW 260
Cdd:COG2271 162 --GWRAAFLILGLPGLLLALLRFWL------------------------------------------LALAYFLVYFALY 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 261 TFLFWLPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLlkrgvatGRARKRAMFVCALFALPVMFAV-QASN 339
Cdd:COG2271 198 GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL-------GRRRKLVLAIGLLLAALALLLLaLLPS 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 916435700 340 IWIAVAFIGLACAAHQGFSTNLFSLPGDLFPRYAQGTLVGLGGFAGAAGGFIASKSLGLLLDTVGsYQPFFIACGLAY 417
Cdd:COG2271 271 PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALA 347
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
37-416 |
4.06e-48 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 169.44 E-value: 4.06e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 37 AVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTS 116
Cdd:TIGR00893 2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 117 TTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFAlnWRWAFIVTGLFNV 196
Cdd:TIGR00893 82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFS--WQWAFIIEGVLGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 197 VWLGLWFWLYRKPADHPR-LTPEERAWIETEPSVD--------VGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLP 267
Cdd:TIGR00893 160 IWGVLWLKFIPDPPQKAKwLTEEEKYIVVGGLLAEqqgkgpstPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 268 DFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATGRARKRAMfVCALFALPVMFAVQASNI-WIAVAF 346
Cdd:TIGR00893 240 TYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAI-IAGLVLSLLMFATNYVNIpYAALAL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 916435700 347 IGLACAAHqGFSTNLFSLPGDLFPRYAQGTLVGLGGFAGAAGGFIASKSLGLLLDTVGSYQP-FFIACGLA 416
Cdd:TIGR00893 319 VALGFFGL-GAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGaLMVVAALA 388
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-417 |
1.11e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 162.74 E-value: 1.11e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 25 RVRWIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATW 104
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 105 TIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFAlnW 184
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG--W 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 185 RWAFIVTGLFNVVWLGLWFWLYRKPADHPRLTPEERawietepsvdvgRATFRSVLRHRETWAYMAGRFLIDPVWWTFLF 264
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS------------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 265 WLPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATGrarkrAMFVCALFALPVMFAvqASNIWIAV 344
Cdd:COG2223 227 WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI-----VFALMALGLLLLALA--LGSLWLFL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 916435700 345 AFIGLACAAHQGFSTNLFSLPGDLFPRYAQGTLVGLGGFAGAAGGFIASKSLGLLLDTVGSYQPFFIACGLAY 417
Cdd:COG2223 300 VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLA 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
33-376 |
2.13e-35 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 133.70 E-value: 2.13e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 33 LLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQV 112
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 113 LVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVTG 192
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 193 LFNVVWLgLWFWLYRKPADHPRLTPEERAWIetepsvdvGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPdFFSK 272
Cdd:pfam07690 159 ILSLLAA-VLLLLPRPPPESKRPKPAEEARL--------SLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 273 QYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRgvatgRARKRAMFVCALFALPVMFAVQASNIWIAVAFIGLACA 352
Cdd:pfam07690 229 VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR-----RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGF 303
|
330 340
....*....|....*....|....
gi 916435700 353 AHQGFSTNLFSLPGDLFPRYAQGT 376
Cdd:pfam07690 304 GFGLVFPALNALVSDLAPKEERGT 327
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
25-376 |
1.03e-34 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 132.02 E-value: 1.03e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 25 RVRWIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATW 104
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 105 TIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNW 184
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF--GW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 185 RWAFIVTGLFNVV-WLGLWFWLyrkpadhPRLTPEERAWIetepsvdvgRATFRSVLRHRETWAYMAGRFLIDPVWWTFL 263
Cdd:COG2814 164 RWVFLVNAVLALLaLLLLLRLL-------PESRPAARARL---------RGSLRELLRRPRLLLLLLLAFLLGFGFFALF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 264 FWLPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLlkrgvatgrARKRAMFVC-ALFALPVMFAVQASNIWI 342
Cdd:COG2814 228 TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF---------GRRRLLLIGlLLLALGLLLLALAGSLWL 298
|
330 340 350
....*....|....*....|....*....|....
gi 916435700 343 AVAFIGLACAAHQGFSTNLFSLPGDLFPRYAQGT 376
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPEARGR 332
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
32-373 |
8.06e-32 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 124.20 E-value: 8.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 32 GLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQ 111
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 112 VLV--TSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFI 189
Cdd:cd17380 82 PLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY--GWPSVFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 190 VTGLFNVVWLGLWFWLYrkpadhprltpeerawietepsvdvgratfrsvlrhRETWAYMAGRFLIDPVWWTFLFWLPDF 269
Cdd:cd17380 160 FFGLLGLLWALVWLIYL------------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTY 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 270 FSKQYGYDLKSFG----PPLVAIyiladFGAISGGWYSSHLLKRGVATGRARKRAMFVCALF-ALPVMFAVQASNIWIAV 344
Cdd:cd17380 204 FHEVLVPLAKGWVfnvvPWLVMF-----PSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGpALFLLLLSHTDSFSLAL 278
|
330 340 350
....*....|....*....|....*....|...
gi 916435700 345 AF----IGLACAAHQGFSTNlfslPGDLFPRYA 373
Cdd:cd17380 279 LCmsvaLGLSAFSSSGVLVN----HQDIAPNYA 307
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
34-417 |
2.36e-26 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 109.44 E-value: 2.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 34 LFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVL 113
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 114 VTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFALNWRWAFIVTGL 193
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 194 FNVVWLGLWFWLYRKPADHPRLTPEERAWIETepsvdvgRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQ 273
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSV-------LKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 274 YGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRgvatgraRKRAMFVCALFALPVMFAVQASNIWIAVAFIGLACAA 353
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR-------KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFG 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 916435700 354 HQGFSTNLFSLPGDLFPRYAQGTLVGLGGFAGAAGGFIASKSLGLLLDTVGSYQPFFIACGLAY 417
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLL 370
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-376 |
4.19e-26 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 108.62 E-value: 4.19e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 35 FAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLV 114
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 115 TSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVsLLVVTFALNWRWAFIVTGLF 194
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLV-LFGIAELYSWHWVFIVPGII 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 195 NVVWLGLWFWLYRKPADHPRLTPEERAWIEtEPSVDVGRA---------TFRSVLRHRETWAYMAGRFLIDPVWWTFLFW 265
Cdd:TIGR00881 160 AIIVSLICFLLLRDSPQSCGLPPAEEMPNE-EPDGDAEKKeeeltkkqiFLQYVLLNKVLWYISLGYVFVYVVRTGILDW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 266 LPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLK-RGVATGRARKRAMFVCALFALPVMFavqASNIWIAV 344
Cdd:TIGR00881 239 SPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNgRRGPLAVFFMALIIVSLLVYWLNPA---ANPLMDLI 315
|
330 340 350
....*....|....*....|....*....|..
gi 916435700 345 AFIGLACAAHqGFSTNLFSLPGDLFPRYAQGT 376
Cdd:TIGR00881 316 CLFALGFLVY-GPQMLIGVIASELAPKKAAGT 346
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-374 |
5.06e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 103.03 E-value: 5.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 12 PETAEHAVPRPRGRVRWIICGLLFAAVVLSyIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRI 91
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLR-PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 92 GAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKeRALAIGIFNAGANVGAVVTPL 171
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 172 LVSLLVVtfALNWRWAFIVTGLFNVVWLGLWFWLYRKPADHPRLTPeerawietepsvdvGRATFRSVLRHRETWAYMAG 251
Cdd:COG2807 160 LTVPLAA--ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAP--------------AAASLRSLWRSPLAWLLTLF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 252 RFLIDPVWWTFLFWLPDFFSkQYGYDLkSFGPPLVAIYILAD-FGAISGGWYSSHL-LKRGVATGrarkraMFVCALFAL 329
Cdd:COG2807 224 FGLQSLLYYAVVAWLPPILR-DAGLSA-ATAGLLLSLFQLAGiPGSLLVPLLADRLgDRRPLLLL------LGLLGLAGL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 916435700 330 PVMFAVQASNIWIAVAFIGLACAAhqGFSTnLFSLPGDLFPRYAQ 374
Cdd:COG2807 296 LGLLLAPGSLPWLWAVLLGLGQGG--LFPL-ALTLIGLRARTPAE 337
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
59-377 |
2.85e-21 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 94.99 E-value: 2.85e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 59 YGWSNtgygDITGYFQVCYGFGFLF----FGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTST--TGFVIARIPLALGEA 132
Cdd:cd17318 51 FDWSE----KTQGIILSSFFYGYILtqipGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGALIVLRILQGLAQG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 133 GTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTfaLNWRWAFIVTGLFNVVWLGLWFWLyrkpadh 212
Cdd:cd17318 127 VTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCES--LGWPSIFYIFGGLGLLWCLLWFFL------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 213 prltpeerawietepSVDVgratfrsvlrhretWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKSFGPPLVAIYILA 292
Cdd:cd17318 198 ---------------VLPV--------------WAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAM 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 293 DFGAISGGWYSSHLLKRGV-ATGRARKRAMFVC----ALFALPVMFAvqASNIWIAVAF----IGLACAAHQGFSTNLFs 363
Cdd:cd17318 249 WICSIVGGYLADWLRSRGIlSTTTVRKLFTSIGflgpGVFLIALGYL--GSNATLAVVFltlsVGLSGACYSGFLVNHL- 325
|
330
....*....|....
gi 916435700 364 lpgDLFPRYAqGTL 377
Cdd:cd17318 326 ---DLAPNYA-GTL 335
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
34-416 |
1.44e-20 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 92.69 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 34 LFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKtgYLLAVATWTIG--HLAQ 111
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGER--RVLAVGLLLMGaaALLM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 112 VLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVT 191
Cdd:cd17475 79 ALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHY--GWRAAFVVA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 192 GLFNVVWLGLWFWLYRKPADHPRLTpeerawietePSVDVGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFS 271
Cdd:cd17475 157 GLVSILAAVLFWLFYREPPAASAAT----------ESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLH 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 272 KQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLlkrgvaTGRARKRAM----FVCALFALPVMFAVQASNIWIAV--- 344
Cdd:cd17475 227 DHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRV------FGGRRRPVLvitaAIAAAALLVLSLLSPGTPLWLLVlll 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 916435700 345 AFIGLACAAHQGFStnlFSLPGDLFPRYAQGTLVGLGGFAGAAGGFIASKSLGLLLDTVGSYQPFFIACGLA 416
Cdd:cd17475 301 ILLGLFAIGWNGLY---LTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALL 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
20-301 |
5.79e-20 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 89.87 E-value: 5.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 20 PRPRGRVRWIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLL 99
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 100 AVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVT 179
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 180 FAlnWRWAFIVTGLFNVVWLGLWFWLYRKPADHPRLTPEERAWIETEPSVDVGRATFRSVLRHRETWAYMAGRFLIDPVW 259
Cdd:COG0477 165 LG--WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLL 242
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 916435700 260 WTFLFWLPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGW 301
Cdd:COG0477 243 LALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
32-350 |
7.87e-20 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 90.76 E-value: 7.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 32 GLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQ 111
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 112 VLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTpLLVSLLVVTFALNWRWAFIVT 191
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG-YVVGGLVAQATGGWRWAFRVT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 192 GLFNVVwLGLWFWLYRKPadhPRLTPEERAWIETEPSVDVGRATfRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFS 271
Cdd:cd17328 161 GVLGVL-LAILLLLFVRE---PPRGAAEGGVMAKSTATSFLADL-KALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 272 KQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATG-RARKR----AMFVCALFALPVMFAVQaSNIWIAVAF 346
Cdd:cd17328 236 RAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTpRADPLvcavGLLAAAPFLFLALVLAL-SNLLLAWVL 314
|
....
gi 916435700 347 IGLA 350
Cdd:cd17328 315 LFLG 318
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-377 |
2.02e-19 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 89.53 E-value: 2.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 20 PRPRGRVRWIICGLLFA-AVVLSyidrlVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYL 98
Cdd:COG0738 3 KKNYRRALIAIYLLFFLwGFATA-----LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 99 LAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALaIGIFNAGANVGAVVTPLLVSLLV- 177
Cdd:COG0738 78 LGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLIl 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 178 VTFALNWRWAFIVTGLFnVVWLGLWFWLYRKPadhprltpeerAWIETEPSVDVGRATFRSVLRHRETWAYMAGRFLIDP 257
Cdd:COG0738 157 LGLSLSWHLPYLILAVL-LLLLALLFLRSKLP-----------EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 258 VWWTFLFWLPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWysshLLKRgvatgRARKRAMFVCALFALPVMF-AVQ 336
Cdd:COG0738 225 AEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF----LLKR-----FGPVRLLRLSALLAAVGLLlALL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 916435700 337 ASNIWIAV---AFIGLACAAhqGFSTnLFSLPGDLFPRYAQGTL 377
Cdd:COG0738 296 APGPWLALiglALVGLGLSL--MFPT-IFSLALDGLGKRTAAAV 336
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
20-378 |
8.95e-19 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 87.80 E-value: 8.95e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 20 PRPRGRVRWIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLL 99
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 100 AVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVT 179
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 180 FAlnWRWAFIVTGLFNVVWLG-LWFWL----------------YRKPADHPRLTPEERAWIETEPS-VDVGRATFRSVL- 240
Cdd:TIGR00895 168 FG--WRSLFYVGGIAPLLLLLlLMRFLpesidflvskrpetvrRIVNAIAPQMQAEAQSALPEQKStQGTKRSVFKALFq 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 241 --RHRETWAYMAGRFLIDPVWWTFLFWLPdFFSKQYGYDLKSFGPPLVAIYiladFGAISGGWYSSHL---LKRGVATGR 315
Cdd:TIGR00895 246 gkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFN----FGGVIGSIIFGWLadrLGPRVTALL 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 916435700 316 ARKRAMFVCALFAlpvmFAVQASNIWIAVAFIGLACAAHQGfstNLFSLPGDLFPRYAQGTLV 378
Cdd:TIGR00895 321 LLLGAVFAVLVGS----TLFSPTLLLLLGAIAGFFVNGGQS---GLYALMALFYPTAIRATGV 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-376 |
2.95e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.01 E-value: 2.95e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 34 LFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVL 113
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 114 VTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVvtFALNWRWAFIVTGL 193
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA--DALGYRAPFLVCAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 194 FNVVwLGLWFWLYRKPADHPRltpeerawIETEPSVDVGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQ 273
Cdd:cd17325 159 LALL-ALVLALLLLPEPRPPP--------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 274 YGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATGrarkrAMFVCALFALPVMFAVQASNIWIAVAFIGLACAA 353
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI-----GLLLSAVALLLLPLATSFWLLLLLLALLGLGLGL 304
|
330 340
....*....|....*....|...
gi 916435700 354 hqgFSTNLFSLPGDLFPRYAQGT 376
Cdd:cd17325 305 ---VFPATLALLADIVPPEGRGT 324
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
33-371 |
1.96e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 80.29 E-value: 1.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 33 LLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQV 112
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 113 LVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLvvTFALNWRWAFIVTG 192
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL--GQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 193 LFNVV-WLGLWFWLYRKPADHPRLTPEERAwietepsvdvgratFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFS 271
Cdd:cd17324 161 VLALLaALLLWRLLPSLPPKKPGSLGLLSS--------------LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 272 KQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATGrarkrAMFVCALFALPVMFavqASNIWIAVAFIGLAC 351
Cdd:cd17324 227 DVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA-----LLLLAAALLLLTLL---GPSPLLLLVGLVLWG 298
|
330 340
....*....|....*....|
gi 916435700 352 AAHQGFSTNLFSLPGDLFPR 371
Cdd:cd17324 299 LGFFAAHSALQTRVLRLAPE 318
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-370 |
3.54e-16 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 79.57 E-value: 3.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 32 GLLFAAVVLSYIDRLVLGVLKPELSATYGW----SNTGYGDITGYFQvcYGFGFLFFGWLIDRIGAKTGYLLAVATWTIG 107
Cdd:cd17316 2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSLglslLQTGLLFAAGFLG--RPIGALLFGYLGDRIGRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 108 HLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLV--VTFALNWR 185
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIplLSGDWGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 186 WAFIVTGLfnvvwLGLWFWLYRKPadhprltpeerawietepsvdvgratfrsvlrhreTWAYMAGRFLIDPVWWTFLFW 265
Cdd:cd17316 160 ILFLIGAL-----PALLALLLRRR-----------------------------------TLLLILLWFFISFGYYGLTTF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 266 LPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATGrarkrAMFVCALFALPVMFAVQASNIWIAVA 345
Cdd:cd17316 200 LPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVI-----GLILSGILALPLFYLLSGSPTLLLLL 274
|
330 340
....*....|....*....|....*
gi 916435700 346 FIGLAcAAHQGFSTNLFSLPGDLFP 370
Cdd:cd17316 275 LFILS-FFVGGVWGALYAYLAELFP 298
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
27-376 |
5.17e-15 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 76.16 E-value: 5.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 27 RWIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAK----TGYLL-AV 101
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRrfmsAGLLLsAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 102 ATWTIGHLAQVLVtsttgFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFa 181
Cdd:cd17312 81 ANIFMGFSTSLWF-----FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 182 lNWRWAFIVTGLFNVVWLGLWFWLYRkpaDHPRLtpeerawietepsvdvgratfrsvlrhreTWAYMAGRFLIDPVWWT 261
Cdd:cd17312 155 -GWRAAFLVPGIVGLVVAIILFFFLR---DSPPY-----------------------------VWVLSLAYAFVYIVRYA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 262 FLFWLPDFFSKQYGYDLKSFGpplvAIYILADFGAISGGWYSSHLLKRGVATGRARKRAMFVCAL-FALPVMFAVQASNI 340
Cdd:cd17312 202 CLDWGPLYLYEVKGYSLIDAG----WFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMtLSLALFWFFPHNKL 277
|
330 340 350
....*....|....*....|....*....|....*...
gi 916435700 341 WIAVAFIglACAAHQGFSTNLFSL--PGDLFPRYAQGT 376
Cdd:cd17312 278 LSIVLLF--LIGFFVGGPINLIGGaaAQDIGRKEAAGT 313
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
28-415 |
1.40e-14 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 75.00 E-value: 1.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 28 WIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIG 107
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 108 HLAQVLVTSTTGFVIARIPLALGEAGT-YPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRW 186
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGTlAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAF--GWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 187 AFIVTGLFN-VVWLGLWFWLYRKPADHPrltpeerAWIETEPSVDVGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFW 265
Cdd:cd17355 160 ALLVLALLAlLVLVPVLLLLRRRPADLA-------LRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVH 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 266 LPDFFsKQYGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATGRARKRAMFVCALFALPVMFAVqasnIWIAVA 345
Cdd:cd17355 233 LVPYL-ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLA----LLLFAA 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 346 FIGLACAAHQGFSTNLFSlpgDLFPRYAQGTLVGLGGFAGAAGGFIASKSLGLLLDTVGSYQPFFIACGL 415
Cdd:cd17355 308 LFGLGWGATVPLTAALAA---RYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVA 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
69-373 |
3.26e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 70.68 E-value: 3.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 69 ITGYFqVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPK 148
Cdd:cd17320 40 LSAYL-LGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 149 KERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVTGLFNVVwLGLWFWLYRkpadhprltPEERAWIETEPS 228
Cdd:cd17320 119 AELAKIFSLLMMILAIAPALAPLLGGLLLLFF--GWRAIFVFLALLGLL-LLLLVLLFL---------PETLPEEKRKPL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 229 VDVGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKSFG---PPLVAIYILADF--GAISGGWYS 303
Cdd:cd17320 187 LSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGllfALNAIALILGSLlnGRLVRRFGP 266
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 304 SHLLKRGVATgrarkramFVCALFALPVMFAVQASNIWIAVAFIGLACAAHQGFSTNLFSLPGDLFPRYA 373
Cdd:cd17320 267 RRLLRLGLLL--------LLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA 328
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-376 |
3.91e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 70.41 E-value: 3.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 31 CGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLA 110
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 111 QVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLL--VVTFALNWRWAF 188
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLfpLLPPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 189 IVTGLFNVVWLglwfWLYRKPADHPRLTPEERAWIETEPSVDVGRATFRSVLRHRETWAYMAGRFLIdpVWWTFLFWLPD 268
Cdd:cd17371 161 LLGALPALLVL----FIRRFVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALG--GYYGITTWLPS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 269 FFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSshllkrgVATGRARKRAMF-VCALFALPVMFAVQASN--IWIAVA 345
Cdd:cd17371 235 YLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLA-------DRIGRRNNFALFaLGSAISILLYFFLPLSPtlILILGF 307
|
330 340 350
....*....|....*....|....*....|.
gi 916435700 346 FIGLACAAHQGFSTNLFSlpgDLFPRYAQGT 376
Cdd:cd17371 308 PLGFFASGPFSGMGAYLT---ELFPTAVRAT 335
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
69-201 |
8.66e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 69.12 E-value: 8.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 69 ITGYFQVCYGFgFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPK 148
Cdd:cd17321 37 VNAYLLAFAAL-LLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPG 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 916435700 149 KERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVTGLFNVVWLGL 201
Cdd:cd17321 116 ERRGRALGLWGAVVGIGAALGPLLGGLLLELF--GWRWIFLINVPIGLVALLL 166
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-210 |
1.62e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 68.36 E-value: 1.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 28 WIICGLLFAAVVLSYidrLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATW--T 105
Cdd:COG2271 183 WLLALAYFLVYFALY---GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLlaA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 106 IGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWR 185
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT--GYQ 337
|
170 180
....*....|....*....|....*
gi 916435700 186 WAFIVTGLFNVVWLGLWFWLYRKPA 210
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
66-311 |
3.19e-12 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 67.66 E-value: 3.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 66 YGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQW 145
Cdd:cd17327 43 YNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 146 FPKKERALAIGIFNAGANVGAVVTPLLVS-----LLVVTFAlNWRWAFIVTGLFNVVW-LGLWFWLYRKPADHPRLTPEE 219
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSIFGGLLAYgvfkiLGVGGLA-GWRWLFIIEGLITIIIgLVIFFWLPDNPSKAWFLTEEE 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 220 RAWI--------ETEPSVDVGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKSFGPPlVAIYIL 291
Cdd:cd17327 202 KELAverlranqTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLS-VPIGAL 280
|
250 260
....*....|....*....|
gi 916435700 292 ADFGAISGGWYSSHLLKRGV 311
Cdd:cd17327 281 GAVSLLIAALLSDRFKKRGL 300
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
82-353 |
5.68e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.83 E-value: 5.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 82 LFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAG 161
Cdd:cd17473 53 PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 162 ANVGAVVTPLLVSLLVvtfALNWRWAFIVTGLFNVVWLGLWFWLYRKPADHPRLTPEERAWIETEPSVDVgratfrsvlr 241
Cdd:cd17473 133 MSLGGVVFLLLGGALA---EIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRV---------- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 242 hretWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKSFGpplVAIYILADFGAIsGGWYSSHLLKRgvatgRARKRAM 321
Cdd:cd17473 200 ----LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIG---LALAIASLAGAI-GALLFGRLKRR-----LGKRRLL 266
|
250 260 270
....*....|....*....|....*....|...
gi 916435700 322 FVC-ALFALPVMFAVQASNIWIAVAFIGLACAA 353
Cdd:cd17473 267 AIGfALMALGFLLLALASGLWVVLLGAILAGLG 299
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
32-205 |
1.05e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.68 E-value: 1.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 32 GLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQ 111
Cdd:cd17365 2 ALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 112 VLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVT 191
Cdd:cd17365 82 AFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF--GWRSVFLLG 159
|
170
....*....|....*....
gi 916435700 192 G-----LFNVVWLGLWFWL 205
Cdd:cd17365 160 GvppliLLPLLRGTLLLWV 178
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
47-353 |
2.05e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 64.88 E-value: 2.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 47 VLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIP 126
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 127 LALGEAGTYPSALAAVSQwFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFA-LNWRWAFIVTGLfnvvwLGLWFWL 205
Cdd:cd17478 94 AGIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGgLGLLILLIIPGL-----AVALLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 206 YRKPADHPRLTPEERAWIETEPSVDVGRATFR----SVLRhreTWAYMAgrflidpvwwtFLFWLPdFFSKQYGYDLKSF 281
Cdd:cd17478 168 RLRPLKKPEAKKAAAKSSARSTLKGVWRALLLlliiVFLR---SWVLSS-----------LTTFLP-FYLVQRGYSLVFA 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 916435700 282 GPPLVAIYILADFGAISGGWYSSHLlkrgvatgrARKRAMFVCALFALPVMFAVQASNIWIAVAFIGLACAA 353
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRF---------GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFL 295
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-246 |
3.10e-11 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 64.55 E-value: 3.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 49 GVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLA 128
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 129 -LGEAGTYPSALAAVSQWFPKKeRALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVTGLFNVVWLGLWFWLYR 207
Cdd:cd17353 103 gIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTV--GVPTTFLILGIIFLIIIVIGAFLIR 179
|
170 180 190
....*....|....*....|....*....|....*....
gi 916435700 208 KPADHPrlTPEERAWIETEPSVDVGRATFRSVLRHRETW 246
Cdd:cd17353 180 DPPKGW--VPPGVDPLANNAENSPRDYTPREMLRTPTFW 216
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
55-347 |
3.17e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.56 E-value: 3.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 55 LSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGT 134
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 135 YPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLvvtFALNWRWAFIV-TGLFNVVWLGLWFWLyrkpadhP 213
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL---LLYSFRLLFLAaAVLFLLAALVLLFLL-------P 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 214 RLTPEERAWIETEpsvdvGRATFRSVLRHRETWAYMAGRFLIdpvwwTFLFWLPDFFSKQYGYDLKSFGPPLVAIYILAD 293
Cdd:cd17329 176 ETRPKRRAAEKTE-----ILRGYKIVLRDRAFLLFLLASFLI-----SLIYFQLESTLPVYVVEILGLGESLLGLLLALN 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 916435700 294 FGAISGGWYsshLLKRGVATGRARKRAMFVCALFALPVMFAVQASNIWIAVAFI 347
Cdd:cd17329 246 ALLIVLLQF---PVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAM 296
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
79-352 |
3.80e-11 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 64.19 E-value: 3.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 79 FGFLFFGWLIDRIGAKTGYLLAVATWTIGHLA-QVLVTSTTGFVIARIPLALGeAGTYPSALAAVSQWFPKKERALAIGI 157
Cdd:cd17341 49 LLRLPYGFLCDRFGGRRVFIASLLLLLIPLLAlALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 158 FNAGANVGAVVTPLLVSLLV-----VTFALNWRWAFIVTGLFNVVWLGLWFWLYRKPADHPRltpeerawietepSVDVG 232
Cdd:cd17341 128 IAGAGNMGVAVSQLLAPLIAgaivfDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKA-------------SALEF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 233 RATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGydlksfGPPLVAIYILADFGAIS------GGWYSSHL 306
Cdd:cd17341 195 LKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFG------LPLVTAGILAALFPLAGalarpaGGWLSDRF 268
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 916435700 307 LKRGVATGrarkrAMFVCALFALPVMFAVQASNIWIAVAFIGLACA 352
Cdd:cd17341 269 GGRRRLWW-----LFIVMTIGAALLSLSLPTSGTNLVLFLALFVAL 309
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
83-205 |
7.70e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 59.97 E-value: 7.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 83 FFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGA 162
Cdd:TIGR00880 17 LSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGI 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 916435700 163 NVGAVVTPLLVSLLVVtfALNWRWAFIVTGLFN-VVWLGLWFWL 205
Cdd:TIGR00880 97 ALGPLLGPPLGGVLAQ--FLGWRAPFLFLAILAlAAFILLAFLL 138
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
85-190 |
1.64e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 62.21 E-value: 1.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 85 GWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANV 164
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILL 131
|
90 100
....*....|....*....|....*.
gi 916435700 165 GAVVTPLLVSLLVVTFalNWRWAFIV 190
Cdd:cd17503 132 APAIGPTLGGWLTDNL--SWRWIFYI 155
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
52-373 |
4.07e-10 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 61.30 E-value: 4.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 52 KPELSATYGWSNTGYGDITGYFQVCYGFGFLF----FGWLIDRIGakTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPL 127
Cdd:TIGR00894 60 ENELDNIKNPNFKWSGALQGLILSSHFYGQIIiqipVGYLAGKYV--FKWSIGIGMFLSSVISIVIPWAAGGGIALVVFC 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 128 ----ALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTpLLVSLLVVTFALNWRWAFIVTGLFNVVWLGLWF 203
Cdd:TIGR00894 138 rviqGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIF-LPISGWLCESWGGWPMIFYVFGIVGCAWSLLWF 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 204 -WLYRKPADHPRLTPEERAWIET--EPSVDVGR--ATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDL 278
Cdd:TIGR00894 217 vFPADDPSIHPCISKFEKKYINSslQGQKGSTRqsLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSG 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 279 KSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATgRARKRAMFVCALFALPVMFAVQASN----IWIAVAFIGLACAAH 354
Cdd:TIGR00894 297 KENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLS-LTAARKIFNGIGGLGPGIFAYALPYlsaaFYLTIIILTLANAVS 375
|
330
....*....|....*....
gi 916435700 355 QGFSTNLFSLPGDLFPRYA 373
Cdd:TIGR00894 376 SGPLAGVLINSLDLAPRFL 394
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
32-354 |
4.41e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.05 E-value: 4.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 32 GLLFAAVVLSYIDRLVLGVLkPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQ 111
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPIL-PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 112 VLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVvtfALNWRWAFIVT 191
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA---AISWRYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 192 GLFNVVWLGLWFWLYRKPADhprltpeerawiETEPSVDVGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFS 271
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKE------------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 272 KQYGYDLKSFGpplVAIYILADFGAISGGWYsSHLLKRGVatgRARKRAMFVCALFALPVMFAVQASNIWIAVAFIGLAC 351
Cdd:cd17474 227 LLYGISPIIIG---LLFAGWSVLLALGSLFV-GRLLKKRF---GARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFG 299
|
...
gi 916435700 352 AAH 354
Cdd:cd17474 300 LGL 302
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
42-193 |
4.69e-10 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 61.10 E-value: 4.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 42 YIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAK----TGYLLAVATWTIGHLAQVLVTST 117
Cdd:cd17345 16 YLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKrflaIGLILSAIINILIGFVPSATSSV 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 916435700 118 TGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTF-ALNWRWAFIVTGL 193
Cdd:cd17345 96 GLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgDGWWRGAFIFPAI 172
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
49-373 |
1.66e-09 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 59.41 E-value: 1.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 49 GVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKT---GYLLAVATWTIghLAQVLVTSTTGFVIA-R 124
Cdd:cd17381 50 SVEHNETGKKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLllgFGILGTAVFTL--LTPLAADLGAGYLIAvR 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 125 IPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLlvVTFALNWRWAFIVTGLFNVVWLGLWFW 204
Cdd:cd17381 128 ALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGL--ICYYLDWTYVFYIFGAVGLLWFFLWIW 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 205 LyrkpadhprltpeerawieTEPsvdvgratfrsvlrhreTWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKSFGPP 284
Cdd:cd17381 206 L-------------------VMP-----------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 285 LVAIYILADFGAISGGWYSSHLLKRGVATGRARKRAMFVCALFaLPVMFAVQAS----NIWIAVAFIGLAcAAHQGFSTN 360
Cdd:cd17381 250 SALPYLGCWLFMILSGQIADNLREKQNFSTVCVRKIFTLIGMI-GPAVFLLAAGftgcNYSLAVAFLTIS-STLGGFSAS 327
|
330
....*....|....
gi 916435700 361 LFSLPG-DLFPRYA 373
Cdd:cd17381 328 GFNINHlDIAPSYA 341
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
74-208 |
4.03e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 57.59 E-value: 4.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 74 QVCYGFGFL----FFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKK 149
Cdd:cd17317 31 QTIFFLGVLigslLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPK 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 916435700 150 ERALAIGIFNAGANVGAVVTPLLVSLLVvtfalNWRWAFIVTGLFNVVWLGLWFWLYRK 208
Cdd:cd17317 111 YRSFVGILFGLFWALGYMLLALLAYLIR-----DWRWLQLAISLPGLLFLLLLWWLPRR 164
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
34-197 |
6.65e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 57.77 E-value: 6.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 34 LFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVL 113
Cdd:TIGR00711 7 LMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 114 VTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLvvTFALNWRWAFIVT-- 191
Cdd:TIGR00711 87 APNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWI--IENYHWRWIFLINvp 164
|
....*..
gi 916435700 192 -GLFNVV 197
Cdd:TIGR00711 165 iGIIVVV 171
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
34-190 |
1.26e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 56.42 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 34 LFAAVVLSYIDRLVLGVLKPELSAT------YGWSNTGYGDITGYFQvcygfgfLFFGWLIDRIGAKTGYLLAVATWTIG 107
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEfgglslVSWVGTAYLLTSTAFQ-------PIYGKLSDLFGRKWVLLIAIVIFELG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 108 HLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTfaLNWRWA 187
Cdd:cd17502 74 SLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDH--LSWRWC 151
|
...
gi 916435700 188 FIV 190
Cdd:cd17502 152 FYI 154
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
73-333 |
1.69e-08 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 56.17 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 73 FQVCYGFGFLFFGWLIDRIGAKtgYLLavatwTIGHLAQVLVTSTTG------------FVIARIPLALGEAGTYPSALA 140
Cdd:cd17344 71 FLFAYAIGMFFSGHIGERLPLR--YFL-----SFGMLLSGLFTALFGlgyywnihslwyFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 141 AVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTfalNWRWAFIVTGLFnVVWLGLWFWLYrkpadhprltpeer 220
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSS---AWGLSFIVPGII-IAAMGVLVFLF-------------- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 221 aWIETEPSVdvgrATFRSVLrhretwaymagrFLIDPVWWTFLFWLPDFFSKQYGYDLKSFGpplvAIYILADFGAISGG 300
Cdd:cd17344 206 -LVEHPPGV----IEFSLCL------------FFAKLVSYTFLYWLPLYISNTAILSAKKAG----DLSTLFDVGGIVGG 264
|
250 260 270
....*....|....*....|....*....|....*
gi 916435700 301 wysshlLKRGVATGRARKRAMFVCALFAL--PVMF 333
Cdd:cd17344 265 ------ILAGYISDYTGGRATTCAAMLILaaPMLF 293
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
30-230 |
2.49e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 56.10 E-value: 2.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 30 ICGLLFAAVVLSYIDRLVLGvlkpelSATYGWSNTGYgditgyfQVCYGFGFLFFGWLIDRIGAKtgyLLAVATWTIGHL 109
Cdd:cd06179 11 LFGVTLPAAVLPFIVADLGP------SSNSTWISTAW-------SLAQAVLGPIVGRLSDLFGRR---WFFIGGNLLGVV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 110 AQVLV---TSTTGFVIARIPLALGeAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFALNWRW 186
Cdd:cd06179 75 GSIVAgtaKSVNMLIGGQALIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRW 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 916435700 187 AFIVTGLFNVVWLGLWFWLYRKPadhPRLTPEERAWIETEPSVD 230
Cdd:cd06179 154 IFYINAIFNALALILLFFFYHPP---PRPQLHGSSTRQKLKRLD 194
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
80-378 |
4.16e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 54.97 E-value: 4.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 80 GFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFN 159
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMY 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 160 AGANVGAVVTPLLVSLLVVtfALNWRWAFIVTGLFNVVWLGLWFwlyrkpadhpRLTPEERAWIETEPSvDVGRATFRSV 239
Cdd:PRK11551 146 CGVPFGGALASVIGVLAAG--DAAWRHIFYVGGVGPLLLVPLLM----------RWLPESRAFAQAAGA-GKQRAPVLRA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 240 L----RHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQyGYDLKSFGPPLVAIYILADFGAISGGWYSSHLLKRGVATGr 315
Cdd:PRK11551 213 LfgegRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLL- 290
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 916435700 316 arkraMFVCALFALPVMFAVQASNIWIAVAFIGLACAAhqGFSTNLFSLPGDLFPRYAQGTLV 378
Cdd:PRK11551 291 -----IYAGILASLAALAAAPSFAGMLLAGFAAGLFVV--GGQSVLYALAPLFYPTQVRGTGV 346
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
28-210 |
5.59e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 54.48 E-value: 5.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 28 WIICGLLFAAVVLSYIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIG 107
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 108 HLAQVLVTSTTGFVIAR-IPLALGEAGTYPSALAAVSQWFPKKeRALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRW 186
Cdd:cd17352 82 LLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVGQYFEKK-RGLATGIAVAGSGVGTFVFPPLLRYLLDNY--GWRG 158
|
170 180
....*....|....*....|....*.
gi 916435700 187 AFIVTG--LFNVVWLGLWFWLYRKPA 210
Cdd:cd17352 159 ALLILGglCLNLCVCGLLLRLLKDPT 184
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
33-180 |
8.18e-08 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 54.35 E-value: 8.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 33 LLFAAVVLSY----IDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGH 108
Cdd:PRK14995 6 LTLVIIVLVYipvaIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLAS 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 916435700 109 LAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWF-PKKERALAIGIFNAGANVGAVVTPLLVSLLVVTF 180
Cdd:PRK14995 86 LAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHF 158
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
73-194 |
9.01e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 53.73 E-value: 9.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 73 FQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERA 152
Cdd:cd17323 43 FVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERG 122
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 916435700 153 LAIGIFNAGANVGAVVTPLLVSllVVTFALNWRWAFIVTGLF 194
Cdd:cd17323 123 KAMGVYSLGPLLGPALGPIIGG--FITQSLGWRWIFWFLAII 162
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
82-328 |
9.03e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 53.84 E-value: 9.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 82 LFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTST-TGFVIARIPLALGeAGTYPSALAAVSQWFPKKERALAIGIFNA 160
Cdd:TIGR00886 55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSySVLLLIRLFIGIA-GGSFASCMPWISFFFPKKIQGTALGLAAG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 161 GANVGAVVTPLLVSLLVVTFA--------LNWRWAFiVTGLFNVVWLGLWFwLYRKPADHPRLTPEERAwietepsvdVG 232
Cdd:TIGR00886 134 WGNMGGGVAQFVMPPIIGSLIfgggqpahLAWGWAF-VIVPAGILLLPALL-IFFVGADTPPGKPATGK---------LS 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 233 RATFRSVLRHRETW----AYMA--GRFLidpvwwTFLFWLPDFFSKQYGYDlksfgpPLVAIYILADFGAIS------GG 300
Cdd:TIGR00886 203 FKEALKVFGNRHTWilalLYSVtfGSFL------GVSSIFAMLFKDQFGLS------KVQAGAYASLGGFLGslarpaGG 270
|
250 260
....*....|....*....|....*...
gi 916435700 301 WYSSHLlkrgvatGRARKRAMFVCALFA 328
Cdd:TIGR00886 271 AISDRL-------GGARKLLMNFLGVAM 291
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
79-236 |
2.38e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 52.78 E-value: 2.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 79 FGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIF 158
Cdd:PRK03893 70 FGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFL 149
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 916435700 159 NAGANVGAVVTPLLVSLLVVTFAlnWRWAFIvTGLFNVVwlgLWFWLYRKpadhprlTPEERAWIETEPSVDVGRATF 236
Cdd:PRK03893 150 ISGFSIGAVVAAQVYSLVVPVWG--WRALFF-IGILPII---FALWLRKN-------LPEAEDWKEKHAGKAPVRTMV 214
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
53-205 |
1.02e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 50.34 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 53 PELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEA 132
Cdd:cd17476 22 PIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPA 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 916435700 133 GTYPSALAAVSQWFPK-KERALAIGIFNAGANVGAVVTpLLVSLLVVTFAlNWRWAFIVTGLFNVVWLGL-WFWL 205
Cdd:cd17476 102 FLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALG-GVFGGLFAQLA-WWPWIFWFLAILAAIVAVAaIFWT 174
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
73-309 |
1.99e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 49.69 E-value: 1.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 73 FQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERA 152
Cdd:TIGR00710 49 YLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 153 LAIGIFNAGANVGAVVTPLLVSLLVVTFAlnWRWAFIVTGLFNVVWLGLWFWLyrKPADHPrltPEERAWIETEPSvdvg 232
Cdd:TIGR00710 129 RIYSILMPVLALAPAVAPLLGGYILVWLS--WHAIFAFLSLAGILLSALIFFI--LPETLP---YEARIQISTYFE---- 197
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 916435700 233 raTFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKSFGpplvAIYILADFGAISGGWYSSHLLKR 309
Cdd:TIGR00710 198 --TFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFG----LLFALNIIAMIFGGFLNGRFIKK 268
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
78-203 |
2.34e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 49.38 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 78 GFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGI 157
Cdd:COG2270 288 ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGL 367
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 916435700 158 FNAGANVGAVVTPLLVSLLVVTFAlNWRWAFIVTGLFNVVwlGLWF 203
Cdd:COG2270 368 YALSGKAASFLGPLLFGLVTQLTG-SQRLGILSLIVFFVI--GLVL 410
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
69-205 |
3.33e-06 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 48.76 E-value: 3.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 69 ITGYFQVCYG----FGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEaGTYPSALAAVSQ 144
Cdd:cd17390 32 VIGLIGSVYGalqlFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFK-HTQSLCKAYLSD 110
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 916435700 145 WFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVT---FALNwrwAFIVTGLFNVVWLGLWFWL 205
Cdd:cd17390 111 LVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETdggFYYV---ALLCSAIFILNAGLVWFLL 171
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
73-205 |
4.00e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 48.86 E-value: 4.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 73 FQVCYGFGFL----FFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPK 148
Cdd:TIGR00898 132 TQSCFFVGVLlgsfVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPK 211
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 916435700 149 KERALAIGIFNAGANVGAVVTPLlvsllVVTFALNWRWAFIVTGLFNVVWLGLWFWL 205
Cdd:TIGR00898 212 KQRAIVGTLIQVFFSLGLVLLPL-----VAYFIPDWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
55-210 |
6.38e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.93 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 55 LSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGT 134
Cdd:COG0738 237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 916435700 135 YPSALAAVSQWFPKKeRALAIGIFNAGANVGAVVTPLLVSLLVVTFALnwRWAFIVTGLFNVVWLGLWFWLYRKPA 210
Cdd:COG0738 317 FPTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGL--RAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-194 |
1.12e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 25 RVRWIICGLLFAAVVLSYIdrLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAK----TGYLLA 100
Cdd:cd17316 176 RRRTLLLILLWFFISFGYY--GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKktlvIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 101 VATWTIghLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTF 180
Cdd:cd17316 254 GILALP--LFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
170
....*....|....
gi 916435700 181 ALNWRWAFIVTGLF 194
Cdd:cd17316 332 GGTGVPALILALLA 345
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
60-416 |
1.52e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 1.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 60 GWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSAL 139
Cdd:cd17489 27 GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 140 AAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFALNWrwAFIVTGLFNVV-WLGLWFWLYRKPADHPRLTPE 218
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV--LFIVAAVLALLaLLLVFLVKDPPPVAAEEAEAG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 219 ERAWietepsvdvgratfrSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQyGYDLKSFGPPLVAIYILAdFGAIS 298
Cdd:cd17489 185 TRAF---------------RRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER-GISNAGLFFTVYAIALLL-SRPFS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 299 GGWYSSHllkrgvatgrARKRAMFVCALFALPVMFAV-QASNIW---IAVAFIGLACAAhqgFSTNLFSLPGDLFPRYAQ 374
Cdd:cd17489 248 GKLSDRK----------GPKTVIIPGLLLLALGLLLLsFAGSPWmllLAAVLYGLGFGL---LFPALQALAVDLVPPHRR 314
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 916435700 375 GTLVGLGGFAGAAGGFIASKSLGLLLDTVGsYQPFFIACGLA 416
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVV 355
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
6-207 |
1.53e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 6 DQIATAPETAEHAVPRPRGRVrWIICGLLFAAVVLSYIDRLVLGVLkpeLSATYGWSNTGYGDITGYFQVCYGFGFLFFG 85
Cdd:cd17473 179 KSKSAASPGAATAAALPWKRV-LPIYFLAFLAMLLFYVIPIQLPFL---LQERGGGSAALIGLALAIASLAGAIGALLFG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 86 WLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVG 165
Cdd:cd17473 255 RLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 916435700 166 AVVTPLLVSLLVVTFALNWRwAFIVTGLFNVVwLGLWFWLYR 207
Cdd:cd17473 335 QFLSPLVLGPLVNLTGGLSG-AFLILGVLALV-LAIVLLLLR 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
53-213 |
1.76e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.79 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 53 PELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEA 132
Cdd:COG2807 239 PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 133 GTYPSALAAVSQWFPKKERALAI-GIFNAGANVGAVVTPLLVSLLVVTFAlNWRWAFIVTGLFNVVWLGLWFWLYRKPAD 211
Cdd:COG2807 319 GLFPLALTLIGLRARTPAEAAALsGMAQSVGYLLAALGPLLVGALHDATG-SWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
..
gi 916435700 212 HP 213
Cdd:COG2807 398 DA 399
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
82-197 |
2.41e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.03 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 82 LFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGeAGTYPSALAAVSQWFPKKERALAIGIFNAG 161
Cdd:cd17504 49 PILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSAT 127
|
90 100 110
....*....|....*....|....*....|....*.
gi 916435700 162 ANVGAVVTPLLVSLLVVTfaLNWRWAFIVTGLFNVV 197
Cdd:cd17504 128 FGIGAGIGLPLGGWIVQH--LGWRWIFWTAAPVAVL 161
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
86-203 |
3.38e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 3.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 86 WLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVG 165
Cdd:cd17474 257 LLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLG 336
|
90 100 110
....*....|....*....|....*....|....*...
gi 916435700 166 AVVTPLLVSLLVVTFalNWRWAFIVTGLFNVVWLGLWF 203
Cdd:cd17474 337 QAVGPLLFGLLLEIF--GLSAPFLVGAAIALAAAVLLA 372
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
149-364 |
3.41e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 149 KERALAIGIFNAGANVGAVVTPLLVSLLVVTF----ALNWRWAFIVTGlfnVVWLGLWFWLYrkpadhpRLTPEERAWIE 224
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaALGYRLTALIFA---VLGLLAFLLTF-------FGTKERPVPEE 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 225 TEPSVdvgRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSS 304
Cdd:COG2211 213 EKVSL---KESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK 289
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 305 HLLKRGVATGrarkrAMFVCALFALpVMFAVQASNIWIAVAFIGLACAAHQGFSTNLFSL 364
Cdd:COG2211 290 RFGKKKAFII-----GLLLAALGLL-LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAM 343
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
69-205 |
4.40e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 69 ITGYFQVCYGFGFLFF----GWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGeAGTYPSALAAVSQ 144
Cdd:cd17330 35 YVGLLQSSYSLGQFLAsplwGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLT-GGNVSVAQAYIAD 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 916435700 145 WFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFALnwRWAFIVTGLFNVVWLGL-WFWL 205
Cdd:cd17330 114 ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY--ALPFLVAAALALLNLVLvLFFL 173
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
79-175 |
4.69e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 45.35 E-value: 4.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 79 FGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTG------FVIARIPLALGEAGTYPSALAAVSQWFPKKERA 152
Cdd:cd17364 54 IGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPlgvmgwLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRG 133
|
90 100
....*....|....*....|....*..
gi 916435700 153 LAIGIFNA----GANVGAVVTPLLVSL 175
Cdd:cd17364 134 ALIAAVFAmqgfGILAGAIVTLILSAI 160
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-170 |
4.93e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.10 E-value: 4.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 23 RGRVRWIICGLLFAAVVLSYIDRLVlgvlkPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAV- 101
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYL-----PLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALl 273
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 916435700 102 --ATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTP 170
Cdd:pfam07690 274 llILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
79-372 |
6.93e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 44.83 E-value: 6.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 79 FGFLFFGWLIDRIGAKTGYLLA-----VATWTIGHL---AQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKE 150
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTlllmgIATFLIGLLptyAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 151 RALAIGIFNAGANVGAVVTPLLVSLLVVTF------ALNWRWAFivtgLFNVVWLGLWFWLYRKPADhprlTPEERAWIE 224
Cdd:cd17369 139 RGFYGSFPQLGAPVGLLLATGVFLLLSALLsdeaflSWGWRIPF----LLSAVLVAVGLYIRLRLEE----TPVFRRAKE 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 225 TEpsvDVGRATFRSVLRH--RETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDlKSFGPPLVAIYILADFGAIS-GGW 301
Cdd:cd17369 211 AG---QVVRAPLVEVLRRhwRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVD-RSTVLLAVLIASVVAAITIPlFGW 286
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 916435700 302 YSShllKRGvatgraRKRAMFV----CALFALPVMFAVQASNIW-IAVAFIGLACAAHQGFSTNLFSLPGDLFP---RY 372
Cdd:cd17369 287 LSD---RVG------RRPVYLAgallAALFAFPFFWLLDTGSTWlIVLAAVVVLGVLHGMMYGPQAAFLAELFPtrvRY 356
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
82-203 |
1.01e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.07 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 82 LFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAG 161
Cdd:cd17370 252 YPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTV 331
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 916435700 162 ANVGAVVTPLLVSLLVVTFalNWRWAFIVTGLFNVVWLGLWF 203
Cdd:cd17370 332 VGIGWLLASLIAGYLWDLI--SPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
119-373 |
1.77e-04 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 43.48 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 119 GFVIA-RIPLALGEAGTYPSALAAVSQWFPKKERA-LAIGIFnAGANVGAVVTPLLVSLLVVtfALNWRWAFIVTGLFNV 196
Cdd:cd17382 105 GCVIFvRILQGLVEGVTYPACHGIWRKWAPPLERSrLATTAF-CGSYAGAVVGMPLSGILVQ--YVGWSSPFYVYGVFGI 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 197 VWLGLWFWLyrkpadhprltpeerawieTEPSVDVGRATF-RSvlrhretwaymagrflidpvwWTFLFWL---PDFFSK 272
Cdd:cd17382 182 IWYMFWMLV-------------------SMPVYAIIVANFcRS---------------------WTFYLLLisqPAYFKE 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 273 QYGYDLKSFG-----PPLV-AIYILAdfgaisGGWYSSHLLKRGVATGRArKRAMFVCALF---ALPVMFAVQASNIWIA 343
Cdd:cd17382 222 VFGFDISKVGilsalPHLVmTIIVPI------GGQLADYLRSRGILSTTA-VRKIFNCGGFgmeATFLLVVAFSHSPTVA 294
|
250 260 270
....*....|....*....|....*....|....
gi 916435700 344 VAFIGLACA----AHQGFSTNLFslpgDLFPRYA 373
Cdd:cd17382 295 ISFLVLAVGfsgfAISGFNVNHL----DIAPRYA 324
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
82-364 |
1.99e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 82 LFFGWLIDRIGAKTgyLLAVATWTIGHLAQVLVTSTTGFVIARIPL-------ALGEAGTYPSALAAVSQWFPKKERALA 154
Cdd:cd06173 52 PFAGVLADRFDRRR--LLILADLLRALLAAVLALLALLGSLSLWLLlvlafllGIASAFFGPARQALLPELVPKEQLVRA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 155 IGIFNAGANVGAVVTPLLVSLLVVTFALNWRwAFIVTGLFNVVWLGLWFWlyRKPADHPRLTPEERAWIETepsvdvgRA 234
Cdd:cd06173 130 NALNSLATQLARIIGPALGGLLVALLGPGGA-FAINALSFLLSALLLLFI--RRPPPAAPGESSSLLLRDL-------RE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 235 TFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKSFGpplvAIYILADFGAISGGWYSSHLLKRgvatg 314
Cdd:cd06173 200 GLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG----LLLAAFGVGALLGALLLGRLSKR----- 270
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 916435700 315 RARKRAMFVCA-LFALPVMFAVQASNIWIAVAFIGLACAAHQGFSTNLFSL 364
Cdd:cd06173 271 RRRGRLLLIGAlLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
43-221 |
2.50e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 43.06 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 43 IDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVI 122
Cdd:cd06180 13 IGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 123 ARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVtFALNWRWAFIVTGLFNVVWLGL- 201
Cdd:cd06180 93 LRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLG-GGLSWRAGWLALALLSAVLLLLs 171
|
170 180
....*....|....*....|
gi 916435700 202 WFWLYRKPADHPRLTPEERA 221
Cdd:cd06180 172 FLLLRRGPSAPTEASAAESA 191
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
80-353 |
3.79e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 42.67 E-value: 3.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 80 GFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTS--TTGF------VIARIPLALGEAGTYPSALAAVSQWFPKKER 151
Cdd:cd17367 56 GGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTyaTIGIwapiilLLARLLQGLSVGGEYGTSATYLSEVAPPGRR 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 152 ALAIGIFNAGANVGAVVTPLLVSLLVVTF------ALNWRWAFIVTGLFNVVwlglWFWLYRKpadhprlTPEERAWIET 225
Cdd:cd17367 136 GFYSSFQYVTLIGGQLLALGVLLVLQHTLgedqmaAWGWRIPFLLGGVLAVV----VLWLRRG-------LEETESFEAI 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 226 EPSVDVGRATFRSVLRHRETWAYMAGRFLIDPV-WWTFLFWLPDFFSKQYGYDLKSFGPPLVAIYILADFGAISGGWYSS 304
Cdd:cd17367 205 AESNEASAGTLRELRRHPRELLLVVGLTAGGTLaFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSD 284
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 916435700 305 hllkrgvatgRARKRAMFVC-----ALFALPVMFAVQASNIWIaVAFIGLACAA 353
Cdd:cd17367 285 ----------RIGRRPLLLFfgiggTLATVPLLSALDHTDSPY-TAFALVLVGL 327
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
68-207 |
4.37e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 68 DITGYFQVCYGFGFL----FFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVS 143
Cdd:cd17489 227 SNAGLFFTVYAIALLlsrpFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAV 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 916435700 144 QWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVTGLFNVVWLgLWFWLYR 207
Cdd:cd17489 307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF--GYRAMFLLAAVVVLLAL-VLYIFLL 367
|
|
| cynX |
PRK09705 |
putative cyanate transporter; Provisional |
48-270 |
4.41e-04 |
|
putative cyanate transporter; Provisional
Pssm-ID: 236614 [Multi-domain] Cd Length: 393 Bit Score: 42.49 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 48 LGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPL 127
Cdd:PRK09705 28 VGPLLPQLRQASGMSFSVAALLTALPVVTMGGLALAGSWLHQHVSERRSVAISLLLIAVGALMRELYPQSALLLSSALLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 128 ALGEAGTYPSALAAVSQWFPKKeRALAIGIFNA----GANVGAVVTPLLVSLLVVTF-ALNWrWAfivtgLFNVVWLGLW 202
Cdd:PRK09705 108 GVGIGIIQAVMPSVIKRRFQQR-TPLVMGLWSAalmgGGGLGAAITPWLVQHSETWYqTLAW-WA-----LPAVVALFAW 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 916435700 203 FWLYRKpadHPRLTPEerawietepsvdvGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFF 270
Cdd:PRK09705 181 WWQSAR---EVASSHK-------------TTTTPVRVVFTPRAWTLGVYFGLINGGYASLIAWLPAFY 232
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
42-306 |
4.87e-04 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 42.39 E-value: 4.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 42 YIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFV 121
Cdd:PRK11663 36 YFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSSSLWAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 122 IARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFAlnWRWAFIVTGLFNVVwLGL 201
Cdd:PRK11663 116 LLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHYG--WRYGMMIAGIIAIV-VGL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 202 W-FWLYR-KPAD-------HPRLTPEERAWIETEPSVDVGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSK 272
Cdd:PRK11663 193 FlCWRLRdKPQAmglpsvgEWRHDALELAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSE 272
|
250 260 270
....*....|....*....|....*....|....
gi 916435700 273 QYGYDLKSFGPPLVAIYILADFGAISGGWYSSHL 306
Cdd:PRK11663 273 TLGVDLVTANSAVSMFELGGFIGALVAGWGSDKL 306
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
48-350 |
5.39e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 5.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 48 LGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLvTSTTGFVIARIPL 127
Cdd:cd17339 18 VGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSL-GGIALLFLGTALA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 128 ALGEAGTYPSALAAVSQWFPKKeRALAIGIFNAGANVGAVVTPLLVSLLVVTFALNWRWAFIVTGLFNVVWLGLWFWLYR 207
Cdd:cd17339 97 GAGIAVGNVLLPSLIKRDFPRR-VGLMTGLYTTSMNLGAALASGLSVPLAQALGGGWRGALAIWALPALLALLIWLPQLR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 208 KpadHPRLTPEerawietepsvdVGRATFRSVLRHRETWA---YMAGRFLidpVWWTFLFWLPDFFSkQYGYDLKSFGPP 284
Cdd:cd17339 176 R---RKRAAAA------------AAPLTKISVWRSPLAWQvtlFMGLQSL---LFYTLMAWLPTILI-DAGLSAATAGWL 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 916435700 285 LVAIYILADFGAISGGWYSSHLLKRgvatgraRKRAMFVCALFALPV--MFAVQASNIWIAVAFIGLA 350
Cdd:cd17339 237 LSLFQLVGIPASLLVPILATRLKNQ-------RPIVVLLAVLFIIGVlgLLFAPTALALLWAVLLGLG 297
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
82-212 |
1.06e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 41.02 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 82 LFFGWLIDRI-GAKTGYLLAVATWTIGHLAQVLVT-STTGFVIARIPLALGEAGTYPSALAAVSQWFPKKE--RALAIGI 157
Cdd:cd17346 58 IIGGWLADKVlGARRTVFIGGILMALGYLLLALSPfSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDprRDSGFSI 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 916435700 158 FNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVTG---LFNVVwlglWFWLYRKPADH 212
Cdd:cd17346 138 FYMGINLGAFLAPLLCGTLGDNY--GYHYGFGLAAvgmLLGLL----IFLLGRKKLLE 189
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
79-224 |
1.48e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 40.68 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 79 FGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIF 158
Cdd:PRK12307 68 FGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 916435700 159 NAGANVGAVVTPLLVSLLVVTFAlnWRWAFIVtGLFNVVwLGLWFwlyRKPAdhprltPEERAWIE 224
Cdd:PRK12307 148 VSGFGIGNIIAAYFMPSFAEAYG--WRAAFFV-GLLPVL-LVIYI---RARA------PESKEWEE 200
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
67-177 |
1.80e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.38 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 67 GDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWF 146
Cdd:cd17333 238 GYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNL 317
|
90 100 110
....*....|....*....|....*....|.
gi 916435700 147 PKKeRALAIGIFNAGANVGAVVTPLLVSLLV 177
Cdd:cd17333 318 PYA-KGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
42-166 |
2.14e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 40.42 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 42 YIDRLVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAK--TGYLL---AVATWTIGhLAQVLVTS 116
Cdd:PRK09556 42 YLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKqfLPFLLilsAICMLGFG-ASLGSGSV 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 916435700 117 TTGFVIARIPLA-LGEAGTYPSALAAVSQWFPKKERALAIGIFNAGANVGA 166
Cdd:PRK09556 121 SLGLMIALWALSgFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGG 171
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
68-197 |
2.21e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 40.02 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 68 DITGYFQVCYGFGF------LFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTT-GFV---IARIPLALGEAGTYPS 137
Cdd:cd17396 33 DVAGVAYVISGIGIgrlltiLFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIiAYVfalLAGAANSFLDTGTYPA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 138 ALAAvsqwFPKKErALAIGIFNAGANVGAVVTPLLVSLLVVTfALNWRWAFIVTGLFNVV 197
Cdd:cd17396 113 LMEA----FPKAS-GSANILVKAFVSFGQFLLPFIIAFLAAN-NLWYGWSFIVPAAVLVL 166
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
48-416 |
2.24e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.00 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 48 LGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTG-------YLLAVATWTIGHLAQVLVTSttgF 120
Cdd:cd17333 15 LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTlilglllISLALALIFATPSIYLFVVL---M 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 121 VIARIPLALGEAGTYPSALAAvsqwFPKKeRALAIGIFNAGANVGAVVTPLLVSLLVvTFALNWRWAFIVTGLFNVVWLG 200
Cdd:cd17333 92 FLAGLGAGILDTGANTFVGAL----FEES-SATRLNVLHGFFGLGALIGPLIATSLL-TSELSWSWAYLIIGLIYLLLAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 201 LWFWLYRKPADHPRLTPEerawietepSVDVGRATFRSVLRHRETWAYMAGRFLIDPVWWTFLFWLPDFFSKQYGYDLKS 280
Cdd:cd17333 166 LILLTLFPELPSARNPQQ---------SVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 281 FGPPLVAIYILADFGAISGGWYSSHLlkrgvatgRARKRAMFVC-ALFALPVMFAVQASNIW--IAVAFIGLACAahqGF 357
Cdd:cd17333 237 AGYLLSGFWVGITIGRLLGGPISRRI--------KPHTLLVLSGsGALLGLLILLLAPTLVVglVATALLGLFMA---AL 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 916435700 358 STNLFSLPGDLFPrYAQGTLVGLGGFAGAAGGFIASKSLGLLLDTVGSYQPFFIACGLA 416
Cdd:cd17333 306 FPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILY 363
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
73-174 |
2.54e-03 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 39.91 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 73 FQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGF---VIARIPLALGEAGTY--PSALAAVsqWFP 147
Cdd:cd17398 48 YMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNCLGAWLKLFSSSPDLFwvaMAGQTICALAQVFILgiPPRLAAV--WFG 125
|
90 100 110
....*....|....*....|....*....|.
gi 916435700 148 KKE--RALAIGIF--NAGANVGAVVTPLLVS 174
Cdd:cd17398 126 PDEvsTATAIGVFgnQLGVALGFVLPPLLVP 156
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
58-168 |
2.67e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 39.93 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 58 TYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVL-VTSTTGFVIARIPLALGEAGTyp 136
Cdd:cd17356 39 TYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAaIGKWYQLIVGRIIAGLGVGFA-- 116
|
90 100 110
....*....|....*....|....*....|....
gi 916435700 137 SALAAV--SQWFPKKERALAIGIFNAGANVGAVV 168
Cdd:cd17356 117 SVLVPVyqSEVAPKHIRGTLVSLYQLAITIGILV 150
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
46-208 |
2.70e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 39.83 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 46 LVLGVLKPELSATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARI 125
Cdd:cd17372 16 MLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 126 PLALGEAGtYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTfaLNWRWAFIVTGLFNVVWLGLWFWL 205
Cdd:cd17372 96 LVGLGLGG-GPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPR--LGWRWLLAFSSVPSSLLLVFYRWT 172
|
...
gi 916435700 206 YRK 208
Cdd:cd17372 173 PKT 175
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
79-198 |
3.70e-03 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 39.52 E-value: 3.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 79 FGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAgTYPSALAAVSQWFPKKERALAIGIF 158
Cdd:PLN00028 86 FSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLA-TFVSCQYWMSTMFNGKIVGTANGIA 164
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 916435700 159 NAGANVGAVVTPLLVSLL-------VVTFALNWRWAFIVTGLFNVVW 198
Cdd:PLN00028 165 AGWGNLGGGVTQLLMPLVfplikdaGAPSFTAWRIAFFVPGLLHIIM 211
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
56-205 |
6.37e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.79 E-value: 6.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 56 SATYGWSNTGYGDITGYFQVCYGFGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGF---VIARIPLALGEA 132
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVyqlIVGRVLVGIGVG 117
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 916435700 133 GTYPSALAAVSQWFPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFALN-WRWAFIVTGLFNVVWLGLWFWL 205
Cdd:pfam00083 118 GASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDgWRIPLGLQLVPALLLIIGLLFL 191
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
79-205 |
6.37e-03 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 38.56 E-value: 6.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 79 FGFLFFGWLIDRIGAKTGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAGTYPSALAAVSQWFPKKERALAIGIF 158
Cdd:cd17447 50 MGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLI 129
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 916435700 159 NAGANVGAVVTPLLVSLLvvtfaLNWRWAFIVTGLFNVVWLGLWFWL 205
Cdd:cd17447 130 SLFWTVGNMLLALVAYLI-----RDWRWLILAVTLPCAPGIITWWWV 171
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
57-212 |
9.82e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 37.94 E-value: 9.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 57 ATYGWSNTGYGdITGyFQVCYGFGFLFFGWLIDRIGaktGYLLAVATWTIGHLAQVLVTSTTGFVIARIPLALGEAG--- 133
Cdd:PRK05122 244 AARGWDGAALA-LTL-FGVAFVGARLLFGNLINRLG---GLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGfsl 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916435700 134 TYPS----ALAAVsqwfPKKERALAIGIFNAGANVGAVVTPLLVSLLVVTFalNWRWAFIVTGLFNVVWLGLWFWLYRKP 209
Cdd:PRK05122 319 VFPAlgveAVKRV----PPQNRGAALGAYSVFLDLSLGITGPLAGLVASWF--GYPSIFLAAALAALLGLALTWLLYRRA 392
|
...
gi 916435700 210 ADH 212
Cdd:PRK05122 393 PRA 395
|
|
| |
