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Conserved domains on  [gi|916813216|ref|WP_051420272|]
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type III secretion system invasion protein IagB [Providencia alcalifaciens]

Protein Classification

lysozyme family protein( domain architecture ID 63)

lysozyme family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lyz-like super family cl00222
lysozyme-like domains; This family contains several members, including soluble lytic ...
 4-141 1.62e-75

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


The actual alignment was detected with superfamily member PRK15328:

Pssm-ID: 469668 [Multi-domain]  Cd Length: 160  Bit Score: 222.05  E-value: 1.62e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216   4 LIILLFFPFGVYANCWQHAASIYGIEPELLYAIAQQESGLKPYVIGKNKNGSKDLGVMQINSSHLPRLKELGINEKQLLE 83
Cdd:PRK15328   7 IVIWLLSINTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGISEKQLLQ 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 916813216  84 EPCLSVVVGASILSDMMKVYGYSWEAVGAYNAGISEKRKVARMNYAEKVWSHYKKIKE 141
Cdd:PRK15328  87 DPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSDIRKRYAKKIWENYRKLKG 144
 
Name Accession Description Interval E-value
PRK15328 PRK15328
type III secretion system invasion protein IagB;
4-141 1.62e-75

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 222.05  E-value: 1.62e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216   4 LIILLFFPFGVYANCWQHAASIYGIEPELLYAIAQQESGLKPYVIGKNKNGSKDLGVMQINSSHLPRLKELGINEKQLLE 83
Cdd:PRK15328   7 IVIWLLSINTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGISEKQLLQ 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 916813216  84 EPCLSVVVGASILSDMMKVYGYSWEAVGAYNAGISEKRKVARMNYAEKVWSHYKKIKE 141
Cdd:PRK15328  87 DPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSDIRKRYAKKIWENYRKLKG 144
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 26-138 1.47e-54

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 166.94  E-value: 1.47e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  26 YGIEPELLYAIAQQESGLKPYVIGKNKNGSKDLGVMQINSSHLPRLKELGINEKQLLEEPCLSVVVGASILSDMMKVYGY 105
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREELLNDPCTNIYVGAWILARNIKRYGN 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 916813216 106 SWEAVGAYNAGISEKRKvarmNYAEKVWSHYKK 138
Cdd:cd13400   81 TWKAVGAYNSGTPKKND----KYARKVYRIYRR 109
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 19-133 7.48e-31

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 107.01  E-value: 7.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216   19 WQHAASIYGIEPELLYAIAQQESGLKPYVIgknkNGSKDLGVMQINSSHLPRLKELGINEKQLLEEPCLSVVVGASILSD 98
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAV----SKSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 916813216   99 MMKVYG-YSWEAVGAYNAGISEKRKVARMNYAEKVW 133
Cdd:pfam01464  77 LYKQYGgDLWLALAAYNAGPGRVRKWIKNAGAKDKK 112
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 15-116 8.06e-13

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 63.48  E-value: 8.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  15 YANCWQHAASIYGIEPELLYAIAQQESGLKPYVIgknknGSKD-LGVMQINSS---HLPRLKELGINEKQLLeEPCLSVV 90
Cdd:COG0741  103 YLPLIEEAAKKYGVDPALVLALIRQESAFNPNAV-----SPAGaRGLMQLMPAtarRLGLKLGLGPSPDDLF-DPETNIR 176

                         90       100
                 ....*....|....*....|....*..
gi 916813216  91 VGASILSDMMKVYGYSWE-AVGAYNAG 116
Cdd:COG0741  177 AGAAYLRELLDRFDGDLVlALAAYNAG 203
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
36-65 8.12e-04

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 37.27  E-value: 8.12e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 916813216    36 IAQQESGLKPYVIGKNKNGSKDLGVMQINS 65
Cdd:smart00263  31 LAFHESGYNTQATNYNNGGSTDYGIFQINS 60
 
Name Accession Description Interval E-value
PRK15328 PRK15328
type III secretion system invasion protein IagB;
4-141 1.62e-75

type III secretion system invasion protein IagB;


Pssm-ID: 185228 [Multi-domain]  Cd Length: 160  Bit Score: 222.05  E-value: 1.62e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216   4 LIILLFFPFGVYANCWQHAASIYGIEPELLYAIAQQESGLKPYVIGKNKNGSKDLGVMQINSSHLPRLKELGINEKQLLE 83
Cdd:PRK15328   7 IVIWLLSINTAWADCWLQAEKMFNIESELLYAIAQQESAMKPGAIGHNRDGSTDLGLMQINSFHMKRLKKMGISEKQLLQ 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 916813216  84 EPCLSVVVGASILSDMMKVYGYSWEAVGAYNAGISEKRKVARMNYAEKVWSHYKKIKE 141
Cdd:PRK15328  87 DPCISVIVGASILSDMMKIYGYSWEAVGAYNAGTSPKRSDIRKRYAKKIWENYRKLKG 144
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 26-138 1.47e-54

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 166.94  E-value: 1.47e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  26 YGIEPELLYAIAQQESGLKPYVIGKNKNGSKDLGVMQINSSHLPRLKELGINEKQLLEEPCLSVVVGASILSDMMKVYGY 105
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKNGSYDIGLMQINSIWLPELARYGITREELLNDPCTNIYVGAWILARNIKRYGN 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 916813216 106 SWEAVGAYNAGISEKRKvarmNYAEKVWSHYKK 138
Cdd:cd13400   81 TWKAVGAYNSGTPKKND----KYARKVYRIYRR 109
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 19-133 7.48e-31

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 107.01  E-value: 7.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216   19 WQHAASIYGIEPELLYAIAQQESGLKPYVIgknkNGSKDLGVMQINSSHLPRLKELGINEKQLLEEPCLSVVVGASILSD 98
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAV----SKSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKE 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 916813216   99 MMKVYG-YSWEAVGAYNAGISEKRKVARMNYAEKVW 133
Cdd:pfam01464  77 LYKQYGgDLWLALAAYNAGPGRVRKWIKNAGAKDKK 112
PRK13722 PRK13722
lytic transglycosylase; Provisional
 17-145 7.45e-24

lytic transglycosylase; Provisional


Pssm-ID: 184274 [Multi-domain]  Cd Length: 169  Bit Score: 90.91  E-value: 7.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  17 NCWQHAASIYGIEPELLYAIAQQESGLKPYVIGKNKNGSKDLGVMQINSSHLPRLKELGINEKQLLEEPCLSVVVGASIL 96
Cdd:PRK13722  21 DCFDLAGRDYKIDPDLLRAISWKESRYRVNAIGINPVTGYGSGLMQVDSQHFNELARYGIKPEHLTTDPCMNIYTGAYYL 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 916813216  97 SDMMKVYGYSWEAVGAYNAGI--SEKRKVARMNYAEKVWSHYKKIKEEKLI 145
Cdd:PRK13722 101 AIAFKKWGVSWEAVGAYNAGFrkTERQNQRRLAYASEVYRIYTGIKSSKGI 151
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 30-137 1.88e-14

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 64.93  E-value: 1.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  30 PELLYAIAQQESGLKPYVIgknkNGSKDLGVMQInsshLPRL-KELGINEKQLLEEPCLSVVVGASILSDMMKVYGYSWE 108
Cdd:cd00254    1 PALVLAVIRVESGFNPRAV----SPAGARGLMQL----MPGTaRDLGRRGVDDLFDPEENIRAGARYLRELLDRFGGDLE 72

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 916813216 109 -AVGAYNAGISEKRKVARM---------NYAEKVWSHYK 137
Cdd:cd00254   73 lALAAYNAGPGAVDRWGGGevppyketrNYVQRVLAYYQ 111
LT_VirB1-like cd16892
VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up ...
 27-137 8.80e-14

VirB1-like subfamily; This subfamily includes VirB1 protein, one of twelve proteins making up type IV secretion systems (T4SS). T4SS are macromolecular assemblies generally composed of VirB1-11 and VirD4 proteins, and are used by bacteria to transport material across their membranes. VirB1 acts as a lytic transglycosylase (LT), and is important with respect to piercing the peptidoglycan layer in the periplasm. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381613 [Multi-domain]  Cd Length: 143  Bit Score: 64.10  E-value: 8.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  27 GIEPELLYAIAQQESGLKPYVIGKNKNG-----------------------SKDLGVMQINSSHLPRlkeLGINEKQLLe 83
Cdd:cd16892    8 GVHPETLAAIVQVESGGNPYAIGVNGGKlsrqpktkaeaiatarqliaaghNFDVGLGQINSRNLAR---LGLTVEDVF- 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 916813216  84 EPCLSVVVGASILSD----MMKVYGYSWEAVGA----YNAGiSEKRKvARMNYAEKVWSHYK 137
Cdd:cd16892   84 DPCTNLKAGATILTEcyarAKKTGGDGQAALRAalscYNTG-NFTRG-FSNGYVQKVVAAAG 143
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 20-118 4.09e-13

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 62.49  E-value: 4.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  20 QHAASIYGIEPELLYAIAQQESGLKPYVIGknknGSKDLGVMQInsshLP--------RLKELGINEKQLLeEPCLSVVV 91
Cdd:cd13401   11 ERAAKKNGLDPALVYAIIRQESAFDPDAVS----PAGALGLMQL----MPatakdvakKLGLPYYSPRDLF-DPEYNIRL 81

                         90       100
                 ....*....|....*....|....*...
gi 916813216  92 GASILSDMMKVYGYSWE-AVGAYNAGIS 118
Cdd:cd13401   82 GSAYLAELLDRFDGNPVlALAAYNAGPG 109
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 15-116 8.06e-13

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 63.48  E-value: 8.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  15 YANCWQHAASIYGIEPELLYAIAQQESGLKPYVIgknknGSKD-LGVMQINSS---HLPRLKELGINEKQLLeEPCLSVV 90
Cdd:COG0741  103 YLPLIEEAAKKYGVDPALVLALIRQESAFNPNAV-----SPAGaRGLMQLMPAtarRLGLKLGLGPSPDDLF-DPETNIR 176

                         90       100
                 ....*....|....*....|....*..
gi 916813216  91 VGASILSDMMKVYGYSWE-AVGAYNAG 116
Cdd:COG0741  177 AGAAYLRELLDRFDGDLVlALAAYNAG 203
PRK13888 PRK13888
conjugal transfer protein TrbN; Provisional
 22-88 2.29e-08

conjugal transfer protein TrbN; Provisional


Pssm-ID: 237545  Cd Length: 206  Bit Score: 50.98  E-value: 2.29e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 916813216  22 AASIYGIEPELLYAIAQQESGlKPYVIGKNKNGSKDLGVMQINSSHLPRLKELGINEKQLLEEPCLS 88
Cdd:PRK13888  21 AAVKYEVPANIVLAVAEKEGG-KPGQWVRNTNGTHDVGPMQFNTAYLGDLARYGITANDVAAAGCYS 86
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 20-117 1.89e-07

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 47.53  E-value: 1.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  20 QHAASIYGIEPELLYAIAQQESGLKPYVigKNKNGSKdlGVMQInsshLPR-LKELGINEkqlLEEPCLSVVVGASILSD 98
Cdd:cd13403    2 KKYAEKYGFDWRLLAAQAYQESRFNPNA--RSPAGAR--GLMQL----MPStARELGVND---RLDPEQNIHAGAKYLRY 70

                         90       100
                 ....*....|....*....|....*.
gi 916813216  99 MMKVYGYS-------WEAVGAYNAGI 117
Cdd:cd13403   71 LRDRFPPDidepdrlKFALAAYNAGP 96
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 20-116 2.13e-07

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 47.12  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  20 QHAASIYGIEPELLYAIAQQESGLKPYVIgknknGSKD-LGVMQInsshLPR-----LKELGINE--KQLLEEPCLSVVV 91
Cdd:cd16896    9 EKYAKEYGVDPLLVAAVIKVESNFNPNAV-----SSKGaIGLMQI----MPEtaewiAEKLGLEDfsEDDLYDPETNIRL 79

                         90       100
                 ....*....|....*....|....*.
gi 916813216  92 GASILSDMMKVYGYSWE-AVGAYNAG 116
Cdd:cd16896   80 GTWYLSYLLKEFDGNLVlALAAYNAG 105
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 20-144 1.41e-05

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 43.51  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  20 QHAASIYGIEPELLYAIAQQESGLKPYVigKNKNGSKdlGVMQInsshLPR-LKELGINEKQLLEEpclSVVVGASILSD 98
Cdd:COG4623  269 EKYAEEYGLDWRLLAALAYQESHWNPRA--RSPTGAR--GLMQL----MPAtAKELGVDDRLDPEQ---SIRAGAKYLRW 337

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 916813216  99 MMKVYGYS-------WEAVGAYNAGIS----EKRKVARMNYAEKVWSHYKKIKEEKL 144
Cdd:COG4623  338 LYDRFPEAidepdrwWFALAAYNAGPGhvqdARRLAKKQGLDPDRWFDVEKSQPKYY 394
PRK13864 PRK13864
type IV secretion system lytic transglycosylase VirB1; Provisional
 28-96 1.99e-04

type IV secretion system lytic transglycosylase VirB1; Provisional


Pssm-ID: 237534  Cd Length: 245  Bit Score: 39.84  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916813216  28 IEPELLYAIAQQESGLKPYVIGKNKNG-----------------------SKDLGVMQINSSHlprLKELGINEKQLLeE 84
Cdd:PRK13864  41 VAPSTLAAIAKVESRFDPLAVHDNTTGetlhwqnhaqatqsvrhrlearhSLDVGLMQINSKN---FSVLGLTPDGAL-Q 116

                         90
                 ....*....|..
gi 916813216  85 PCLSVVVGASIL 96
Cdd:PRK13864 117 PCTSLSAAANLL 128
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
20-63 3.15e-04

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 39.65  E-value: 3.15e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 916813216  20 QHAASIYGIEPELLYAIAQQESGLKPYVIgknkNGSKDLGVMQI 63
Cdd:PRK11671 197 RKASRKYGVDESLILAIMQTESSFNPYAV----SRSDALGLMQV 236
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 22-63 7.26e-04

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 37.92  E-value: 7.26e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 916813216  22 AASIYGIEPELLYAIAQQESGLKPYVIGKnkngSKDLGVMQI 63
Cdd:cd16893    6 YAKKYGVDPALILAIIETESSFNPYAVSH----SPAYGLMQI 43
LYZ1 smart00263
Alpha-lactalbumin / lysozyme C;
36-65 8.12e-04

Alpha-lactalbumin / lysozyme C;


Pssm-ID: 197612  Cd Length: 127  Bit Score: 37.27  E-value: 8.12e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 916813216    36 IAQQESGLKPYVIGKNKNGSKDLGVMQINS 65
Cdd:smart00263  31 LAFHESGYNTQATNYNNGGSTDYGIFQINS 60
LYZ_C_invert cd16899
C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive ...
 36-65 1.58e-03

C-type invertebrate lysozyme; C-type lysozyme proteins of invertebrates, including digestive lysozymes 1 and 2 from Musca domestica, which aid in the use of bacteria as a food source. These lysozymes have high expression in the gut and optimal lytic activity at a lower pH. Other lysozymes in this subfamily have immunological roles. e.g. Anopheles gambiae has eight lysozymes, most of which seem to have immunological roles, those some may function as digestive enzymes in larvae. C-type lysozyme (chicken or conventional type; 1, 4-beta-N-acetylmuramidase) has bacteriolytic properties through the hydolysis of beta-1,4, glyocosidic linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan, as well as between N-acetyl-D-glucosamine residues in chitodextrins.


Pssm-ID: 381618 [Multi-domain]  Cd Length: 121  Bit Score: 36.43  E-value: 1.58e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 916813216  36 IAQQESGLKPYVIGK-NKNGSKDLGVMQINS 65
Cdd:cd16899   28 LAEHESSFNTTAVGGpNSDGSGDYGLFQIND 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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