|
Name |
Accession |
Description |
Interval |
E-value |
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
244-435 |
2.70e-46 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 164.34 E-value: 2.70e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 244 NIAHDLKNPLTRLRLHLE--------KEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEHGQFPLKLEPVNGFTLMSDII 315
Cdd:COG5002 171 NVSHELRTPLTSIRGYLEllldgaadDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVV 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 316 DILEPTAEQNQQHIILHKNHEPIF-EGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQL 390
Cdd:COG5002 251 EELRPLAEEKGIELELDLPEDPLLvLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDdqvrISVRDTGIGIPEEDL 330
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 916891199 391 SQLTKRFYRSDLA--RQKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:COG5002 331 PRIFERFYRVDKSrsRETGGTGLGLAIVKHIVEAHGGRIWVESEPGK 377
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
143-435 |
7.02e-46 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 161.61 E-value: 7.02e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 143 VVIATATEHLSRLITEFKTIATWACLLSLVLTCVFGYIFARRHLRRVNYFNNVAEQVQKGDLSARVVHKQKGDEFVTLAK 222
Cdd:COG0642 13 LLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 223 H--INTMLQSIEENFALVQGITDNIAHDLKNPLTRLRLHLE-----KEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEH 295
Cdd:COG0642 93 LllLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLEllleeLDEEQREYLETILRSADRLLRLINDLLDLSRLEA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 296 GQFPLKLEPVNGFTLMSDIIDILEPTAEQNQQHIILHKNHEPI-FEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKS 374
Cdd:COG0642 173 GKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPtVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRRE 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 916891199 375 S----IKISDNGKGVNKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:COG0642 253 GdrvrISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGK 317
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
223-435 |
1.13e-44 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 155.84 E-value: 1.13e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 223 HINTMLQSIEENFALVQGITDNIAHDLKNPLTRLRLHLE--------KEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLE 294
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAEllldeedlSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 295 HGQFPLKLEPVNGFTLMSDIIDILEPTAEQNQQHIILHKNHE-PIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSK 373
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 916891199 374 SS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:COG2205 161 EGdgvrISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGG 226
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
245-435 |
3.27e-27 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 112.75 E-value: 3.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLT-------RLRLHLEKEAIKQP-----SLGIAIEQLESVLHTFDAMLKLTRLEhgqfPLKLEPVNGFTLMS 312
Cdd:COG5000 208 IAHEIKNPLTpiqlsaeRLRRKLADKLEEDRedlerALDTIIRQVDRLKRIVDEFLDFARLP----EPQLEPVDLNELLR 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 313 DIIDILEPTAEQNQQHIILHKN-HEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNK 387
Cdd:COG5000 284 EVLALYEPALKEKDIRLELDLDpDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDgrvrIEVSDNGPGIPE 363
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 916891199 388 QQLSQLTKRFYRSdlarQKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:COG5000 364 EVLERIFEPFFTT----KPKGTGLGLAIVKKIVEEHGGTIELESRPGG 407
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
346-435 |
1.17e-24 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 97.29 E-value: 1.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 346 LFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICD 421
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGdgvvLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90
....*....|....
gi 916891199 422 RHHFTLTLQSDENG 435
Cdd:cd00075 81 AHGGRITVESEPGG 94
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
179-435 |
1.54e-24 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 105.07 E-value: 1.54e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 179 YIFARRHLRRVNYFNNVAEQVQKGDLSARVvHKQKGDEFVTLAKHINTMLQSIEENFALVQGITDNIAHDLKNPLTRLRL 258
Cdd:PRK10604 154 FLWMRPHWQDMLKLEAAAQRLGDGHLAERI-HFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRY 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 259 HLEK----EAIKQPSLGIAIEQLESVLhtfDAMLKLTRLEHGQFPLKLEPVNGFTLMSDIID---ILEPtaeqnQQHIIL 331
Cdd:PRK10604 233 RLEMsdnlSAAESQALNRDIGQLEALI---EELLTYARLDRPQNELHLSEPDLPAWLSTHLAdiqAVTP-----EKTVRL 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 332 HKNHEPIF-EGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKS--SIKISDNGKGVNKQQLSQLTKRFYRSDLARQKD- 407
Cdd:PRK10604 305 DTPHQGDYgALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNqaCLIVEDDGPGIPPEERERVFEPFVRLDPSRDRAt 384
|
250 260
....*....|....*....|....*....
gi 916891199 408 -GFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:PRK10604 385 gGCGLGLAIVHSIALAMGGSVNCDESELG 413
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
341-435 |
1.13e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 95.17 E-value: 1.13e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 341 GDKNLLFQACYNLLQNAIKYAGNHAKITITLS---KSSIKISDNGKGVNKQQLSQLTKRFYRSDlARQKDGFGLGLATVK 417
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSaddGAVIRVEDNGPGIDEEELEALFERFYRSD-GQNYGGSGLGLSIVK 87
|
90
....*....|....*...
gi 916891199 418 AICDRHHFTLTLQSDENG 435
Cdd:cd16940 88 RIVELHGGQIFLGNAQGG 105
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
165-435 |
1.34e-23 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 102.62 E-value: 1.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 165 WACLLSLVLTCVFGYIFA---RRHLRR-VNYFNNVAEQvQKGDLSarvvhKQKGDEFVTLAKHINTMLQSIE-----ENF 235
Cdd:PRK11100 186 WAGALLLGIALLIGAGVVwwlNRSIRRlTRYADAVTEG-KPVPLP-----KLGSSELRELAQALESMRVKLEgkayvEQY 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 236 alVQGITdniaHDLKNPLTRLRLHLE------KEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEHGQFPLKLEPVNGFT 309
Cdd:PRK11100 260 --VQTLT----HELKSPLAAIRGAAEllqedpPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAA 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 310 LMSDIIDILEPTAEQnqQHIILHKNHEPI-FEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKG 384
Cdd:PRK11100 334 LLEELVEAREAQAAA--KGITLRLRPDDArVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGeqvaLSVEDQGPG 411
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 916891199 385 VNKQQLSQLTKRFYrsDLAR---QKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:PRK11100 412 IPDYALPRIFERFY--SLPRpanGRKSTGLGLAFVREVARLHGGEVTLRNRPEG 463
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
194-424 |
1.14e-22 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 100.01 E-value: 1.14e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 194 NVAEQVQKGDLsarVVHK--QKG-DEFVTLAKHINTMLQSIEENFALVQGITDNIAHDLKNPLTRLRLHL---------- 260
Cdd:PRK09470 199 NAADEVAQGNL---RQHPelETGpQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLATallrrrqges 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 261 -EKEAIKqpslgIAIEQLESVLHTfdaMLKLTRLEHGQfPLKLEPVNGFTLMSDIIDILEPTAEQNQQH--IILHKNHEP 337
Cdd:PRK09470 276 kELERIE-----TEAQRLDSMIND---LLVLSRNQQKN-HLERETFKANSLWSEVLEDAKFEAEQMGKSltVSAPPGPWP 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 338 IFeGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKS--SIKISDNGKGVNKQQLSQLTKRFYRSDLA--RQKDGFGLGL 413
Cdd:PRK09470 347 IN-GNPNALASALENIVRNALRYSHTKIEVAFSVDKDglTITVDDDGPGVPEEEREQIFRPFYRVDEArdRESGGTGLGL 425
|
250
....*....|.
gi 916891199 414 ATVKAICDRHH 424
Cdd:PRK09470 426 AIVENAIQQHR 436
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
341-435 |
2.26e-22 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 91.56 E-value: 2.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 341 GDKNLLFQACYNLLQNAIKYAGNHAKITITLSKS----SIKISDNGKGVNKQQLSQLTKRFYRSD-LARQKDGFGLGLAT 415
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSI 80
|
90 100
....*....|....*....|
gi 916891199 416 VKAICDRHHFTLTLQSDENG 435
Cdd:smart00387 81 VKKLVELHGGEISVESEPGG 100
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
341-435 |
1.69e-21 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 88.96 E-value: 1.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 341 GDKNLLFQACYNLLQNAIKYAGNHAKITITLSKS---SIKISDNGKGVNKQQLSQLTKRFYRSDLARQKdGFGLGLATVK 417
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGG-GTGLGLSIVR 79
|
90
....*....|....*...
gi 916891199 418 AICDRHHFTLTLQSDENG 435
Cdd:pfam02518 80 KLVELLGGTITVESEPGG 97
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
233-435 |
4.13e-21 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 95.62 E-value: 4.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 233 ENFALVqgitdnIAHDLKNPL-----------TRLRLHLEKEAIKQpsLGIAIEQLESVLHTFDAMLKLTRLehGQFPLK 301
Cdd:COG4251 283 EQFAYV------ASHDLREPLrkisgfsqlleEDYGDKLDEEGREY--LERIRDAAERMQALIDDLLAYSRV--GRQELE 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 302 LEPVNGFTLMSDIIDILEPTAEQNqqHIILHKNHEPIFEGDKNLLFQACYNLLQNAIKYA--GNHAKITITLSKSS---- 375
Cdd:COG4251 353 FEPVDLNELLEEVLEDLEPRIEER--GAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSrpGEPPRIEIGAEREGgewv 430
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 376 IKISDNGKGVNKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:COG4251 431 FSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGE 490
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
224-441 |
4.83e-21 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 95.10 E-value: 4.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 224 INTMLQSiEENFalvqgiTDNIAHDLKNPLTRLR-------LHLEKEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEHG 296
Cdd:PRK10337 230 THAMMVR-ERRF------TSDAAHELRSPLAALKvqtevaqLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 297 QFPLKLEPVNGFTLM-SDIIDILePTAEQNQQHIILHKN-HEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKS 374
Cdd:PRK10337 303 DNLQDVAEIPLEDLLqSAVMDIY-HTAQQAGIDVRLTLNaHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR 381
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 916891199 375 SIKISDNGKGVNKQQLSQLTKRFYRSDlARQKDGFGLGLATVKAICDRHHFTLTL-QSDENGFSSTIS 441
Cdd:PRK10337 382 NFTVRDNGPGVTPEALARIGERFYRPP-GQEATGSGLGLSIVRRIAKLHGMNVSFgNAPEGGFEAKVS 448
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
244-441 |
5.03e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 94.69 E-value: 5.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 244 NIAHDLKNPLTRLRLHLE-------KEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEHGQFPLKLEPVNgftlMSDIID 316
Cdd:PRK11006 210 NVSHELRTPLTVLQGYLEmmqdqplEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVD----VPMMLR 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 317 ILEPTAE---QNQQHIILHKNHEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQ 389
Cdd:PRK11006 286 VLEREAQtlsQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPqgaeFSVEDNGPGIAPEH 365
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 916891199 390 LSQLTKRFYRSDLARQKD--GFGLGLATVKAICDRHHFTLTLQSdENGFSSTIS 441
Cdd:PRK11006 366 IPRLTERFYRVDKARSRQtgGSGLGLAIVKHALSHHDSRLEIES-EVGKGTRFS 418
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
242-430 |
1.33e-20 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 92.72 E-value: 1.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 242 TDNIAHDLKNPLTRLRLHLE-KEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEH----GQFplklEPVNgftLMSDII- 315
Cdd:PRK10755 141 TADVAHELRTPLAGIRLHLElLEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQsfssGHY----QTVK---LLEDVIl 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 316 ---DILEPTAEQNQQHIIL-HKNHEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSK----SSIKISDNGKGVNK 387
Cdd:PRK10755 214 psqDELSEMLEQRQQTLLLpESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQedggAVLAVEDEGPGIDE 293
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 916891199 388 QQLSQLTKRFYRSDlaRQKDGFGLGLATVKAICDRHHFTLTLQ 430
Cdd:PRK10755 294 SKCGELSKAFVRMD--SRYGGIGLGLSIVSRITQLHHGQFFLQ 334
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
171-435 |
6.88e-20 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 91.51 E-value: 6.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 171 LVLTCVFGYIFAR---RHLRRVNYfnnVAEQVQKGDLSARVvhKQKG-DEFVTLAKHINTMLQSI---EENFALVqgiTD 243
Cdd:PRK09467 163 GLLSVAGGWLFIRiqnRPLVALEH---AALQVGKGEIPPPL--REYGaSEVRSVTRAFNQMAAGIkqlEDDRTLL---MA 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 244 NIAHDLKNPLTRLRLHLE---------KEAIKQPslgiaIEQLESVLHTFDAMLKltrleHGQ-FPLKLEPVNgfTLMSD 313
Cdd:PRK09467 235 GVSHDLRTPLTRIRLATEmmseedgylAESINKD-----IEECNAIIEQFIDYLR-----TGQeMPMEMADLN--ALLGE 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 314 IIdilepTAEQNQQHII-LHKNHEPIfegdkNLLFQ------ACYNLLQNAIKYAGNHAKITITLSKSS--IKISDNGKG 384
Cdd:PRK09467 303 VI-----AAESGYEREIeTALQPGPI-----EVPMNpiaikrALANLVVNAARYGNGWIKVSSGTEGKRawFQVEDDGPG 372
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 916891199 385 VNKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:PRK09467 373 IPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEG 423
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
194-441 |
3.79e-19 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 89.45 E-value: 3.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 194 NVAEQVQK---GDLSARVVHKQKGDEFVTLAKHINTMLQSIEENFALVQGITDNIAHDLKNPLTRLRLHLEkeaikqpsl 270
Cdd:PRK09835 215 SVSRQIQNitsKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTE--------- 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 271 gIAIEQ------LESVLHT-----------FDAMLKLTRLEHGQFPLKLEPVNGFTLMSDIIDILEPTAEQnqQHIILHK 333
Cdd:PRK09835 286 -IALSQsrsqkeLEDVLYSnleeltrmakmVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEE--RGVELRF 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 334 N-HEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQK-- 406
Cdd:PRK09835 363 VgDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDhqvqLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRkg 442
|
250 260 270
....*....|....*....|....*....|....*
gi 916891199 407 DGFGLGLATVKAICDRHHFTLTLQSDENGFSSTIS 441
Cdd:PRK09835 443 EGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVIS 477
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
245-434 |
1.93e-18 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 87.34 E-value: 1.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLTRLR--LHLEKEAIK---QPSLGI---AIEQLESVLHTFdamLKLTRLEHGQFplklEPVNGFTLMSDIID 316
Cdd:COG5809 277 IAHEIRNPLTSLKgfIQLLKDTIDeeqKTYLDImlsELDRIESIISEF---LVLAKPQAIKY----EPKDLNTLIEEVIP 349
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 317 ILEPTAEQNQQHIILHKNH-EPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITL-----SKSSIKISDNGKGVNKQQL 390
Cdd:COG5809 350 LLQPQALLKNVQIELELEDdIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETkaeddDKVVISVTDEGCGIPEERL 429
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 916891199 391 SQLTKRFYrsdlARQKDGFGLGLATVKAICDRHHFTLTLQSDEN 434
Cdd:COG5809 430 KKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKITVESEVG 469
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
233-435 |
7.84e-18 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 84.45 E-value: 7.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 233 ENFALVQGITDNIAHDLKNPLTRLR--LHLEKEAI----KQPSLGIAIEQLE---SVLHTFDAMLKLTRLEHGQFPLKle 303
Cdd:COG5807 142 EKLSVAGELAAGIAHEIRNPLTSIKgfLQLLQESRedseREEYFNIIISEIDrinTIITELLVLSKPKKFNFKKLNLN-- 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 304 pvngfTLMSDIIDILEPTAEQNQQHIILH-KNHEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKI 378
Cdd:COG5807 220 -----DVLEDVIALLSTEAILKNISIKYDlADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGdfvvISV 294
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 916891199 379 SDNGKGVNKQQLSQLTKRFYRSdlarQKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:COG5807 295 KDEGIGIPEEVLEKIGEPFFTT----KEEGTGLGLSICKKIIEEHNGTIEVESKPGK 347
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
218-431 |
1.62e-17 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 83.36 E-value: 1.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 218 VTLAKHINTMLQSIEeNFALVQGITDNIAHDLKNPLT-------RLRLHLEKEAIkQPSLGIAIEQLESVLHTFDAMLKL 290
Cdd:COG3852 116 ITERKRLERELRRAE-KLAAVGELAAGLAHEIRNPLTgirgaaqLLERELPDDEL-REYTQLIIEEADRLNNLVDRLLSF 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 291 TRLEhgqfPLKLEPVNGFTLMSDIIDILEPTAEQNqqhIILHKNHE---PIFEGDKNLLFQACYNLLQNAIKYAGNHAKI 367
Cdd:COG3852 194 SRPR----PPEREPVNLHEVLERVLELLRAEAPKN---IRIVRDYDpslPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTI 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 368 TITLSKSS--------------IKISDNGKGVNKQQLSQL------TKrfyrsdlarqKDGFGLGLATVKAICDRHHFTL 427
Cdd:COG3852 267 TIRTRVERqvtlgglrprlyvrIEVIDNGPGIPEEILDRIfepfftTK----------EKGTGLGLAIVQKIVEQHGGTI 336
|
....
gi 916891199 428 TLQS 431
Cdd:COG3852 337 EVES 340
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
144-440 |
3.91e-16 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 80.06 E-value: 3.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 144 VIATATEHLSR---------------LITEFKTiatwacLLSLVLTcvfgYIFARRHLRRVNYFNNVAEQVQKGDLSARV 208
Cdd:PRK10549 142 VIASPVERLTRntdinfdkqqrrtswLIVALST------LLAALAT----FLLARGLLAPVKRLVEGTHKLAAGDFTTRV 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 209 VHKQKgDEFVTLAKHINTMLQSIEENFALVQGITDNIAHDLKNPLTRLRLHLE--KEAIKQP------SLGIAIEQLESV 280
Cdd:PRK10549 212 TPTSR-DELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEaiQDGVRKFtpesvaSLQAEVGTLTKL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 281 LhtfDAMLKLTRLEHGQFPLKLEPVngftlmsDIIDILEPTA----EQNQQH-IILHKN---HEPIFeGDKNLLFQACYN 352
Cdd:PRK10549 291 V---DDLHQLSLSDEGALAYRKTPV-------DLVPLLEVAGgafrERFASRgLTLQLSlpdSATVF-GDPDRLMQLFNN 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 353 LLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQK--DGFGLGLATVKAICDRHHFT 426
Cdd:PRK10549 360 LLENSLRYTDSGGSLHISAEQRDktlrLTFADSAPGVSDEQLQKLFERFYRTEGSRNRasGGSGLGLAICLNIVEAHNGR 439
|
330
....*....|....*
gi 916891199 427 LTLQ-SDENGFSSTI 440
Cdd:PRK10549 440 IIAAhSPFGGVSITV 454
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
245-435 |
1.61e-15 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 77.53 E-value: 1.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLT-----------RLRLHLEKEAIKQpSLGIAIEQLESVLHTFDAMLKLTRLEhgqfPLKLEPVNGFTLMSD 313
Cdd:COG4191 149 IAHEINNPLAailgnaellrrRLEDEPDPEELRE-ALERILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELIDE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 314 IIDILEPTAEQNQQHIILH-KNHEPIFEGDKNLLFQACYNLLQNAIkYA---GNHAKITITLSKSS----IKISDNGKGV 385
Cdd:COG4191 224 ALELLRPRLKARGIEVELDlPPDLPPVLGDPGQLEQVLLNLLINAI-DAmeeGEGGRITISTRREGdyvvISVRDNGPGI 302
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 916891199 386 NKQQLSQL------TKRfyrsdlarQKDGFGLGLATVKAICDRHHFTLTLQSDENG 435
Cdd:COG4191 303 PPEVLERIfepfftTKP--------VGKGTGLGLSISYGIVEKHGGRIEVESEPGG 350
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
245-431 |
2.37e-15 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 78.54 E-value: 2.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLTRLR-----LHLEKEAIKQPSLGIAIEQLESVLHT---FDAMLKLTRLEHGQFPLK-----LEPVNGFTLM 311
Cdd:PRK10490 671 LSHDLRTPLTVLFgqaeiLTLDLASEGSPHARQASEIRQQVLNTtrlVNNLLDMARIQSGGFNLRkewltLEEVVGSALQ 750
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 312 SdiidiLEPTAEQNQQHIILhKNHEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKS----SIKISDNGKGVNK 387
Cdd:PRK10490 751 M-----LEPGLSGHPINLSL-PEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEgerlQLDVWDNGPGIPP 824
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 388 QQLSQLTKRFYRSDLARQKDGFGLGLATVKAICDRH----------------HFTLTLQS 431
Cdd:PRK10490 825 GQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHggtiwaenrpeggacfRVTLPLET 884
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-424 |
6.69e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 70.43 E-value: 6.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 346 LFQACYNLLQNAIKYAgnHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQKD--GFGLGLATVKAI 419
Cdd:cd16949 1 LARALENVLRNALRYS--PSKILLDISQDGdqwtITITDDGPGVPEDQLEQIFLPFYRVDSARDREsgGTGLGLAIAERA 78
|
....*
gi 916891199 420 CDRHH 424
Cdd:cd16949 79 IEQHG 83
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-431 |
3.01e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 68.77 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 346 LFQACYNLLQNAIKYAGNHAKITITLSK----SSIKISDNGKGVNKQQLSQLTKRFYRSDLA--RQKDGFGLGLATVKAI 419
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQeesgARLSVEDTGPGIPPEHIPRLTERFYRVDIErcRNTGGTGLGLAIVKHV 80
|
90
....*....|..
gi 916891199 420 CDRHHFTLTLQS 431
Cdd:cd16952 81 MSRHDARLLIAS 92
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-435 |
1.56e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 66.33 E-value: 1.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 342 DKNLLFQACYNLLQNAIKYA--GNHAKITITLSKSSIK--ISDNGKGVNKQQLSQLTKRFYRSDLARQKDG-FGLGLATV 416
Cdd:cd16975 1 DTLLLSRALINIISNACQYApeGGTVSISIYDEEEYLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIA 80
|
90
....*....|....*....
gi 916891199 417 KAICDRHHFTLTLQSDENG 435
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKG 99
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-440 |
1.63e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 66.26 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 346 LFQACYNLLQNAIKYAGNHAKITITL----SKSSIKISDNGKGVNKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICD 421
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSfltdDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|.
gi 916891199 422 RHHFTLTLQSDENG--FSSTI 440
Cdd:cd16923 81 LHGGSASAEYDDNHdlFKVRL 101
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
190-434 |
2.21e-13 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 71.69 E-value: 2.21e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 190 NYFNNVAEQVQKGDLSARVVHKQK----------------GDE--FVTLAKHINT-------MLQSieENFALVQGITDN 244
Cdd:COG5805 216 ERIESITEVWQEFIIEREIITKDGriryfeavivplidtdGSVkgILVILRDITEkkeaeelMARS--EKLSIAGQLAAG 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLTRLR-----LHLEKEAIKQ--PSLGIAIEQLESVLHTFDAMLKLTrlehgqfPLKLEPVNGFTLMSDIIDI 317
Cdd:COG5805 294 IAHEIRNPLTSIKgflqlLQPGIEDKEEyfDIMLSELDRIESIISEFLALAKPQ-------AVNKEKENINELIQDVVTL 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 318 LEPTAEQNQQHIILHKNHE-PIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITL----SKSSIKISDNGKGVNKQQLSQ 392
Cdd:COG5805 367 LETEAILHNIQIRLELLDEdPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTeeedNSVIIRVIDEGIGIPEERLKK 446
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 916891199 393 LTKRFYRSdlarQKDGFGLGLATVKAICDRHHFTLTLQSDEN 434
Cdd:COG5805 447 LGEPFFTT----KEKGTGLGLMVSYKIIENHNGTIDIDSKVG 484
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-435 |
2.14e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 63.24 E-value: 2.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 352 NLLQNAIKYAGNHAKITITLSKSSIKIS--DNGKGVNKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICDRHHFTLTL 429
Cdd:cd16950 7 NLVDNALRYGGGWVEVSSDGEGNRTRIQvlDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAHGGSLTL 86
|
....*.
gi 916891199 430 QSDENG 435
Cdd:cd16950 87 ANRAGG 92
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
245-431 |
5.59e-12 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 67.69 E-value: 5.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLTRLR---LHLEKEAIKQPS---LGIAIEQLESVLHTFDAMLKLTRLEHGQFplklEPVNGFTLMSDIIDIL 318
Cdd:PRK11360 397 VAHEIRNPLTAIRgyvQIWRQQTSDPPSqeyLSVVLREVDRLNKVIDQLLEFSRPRESQW----QPVSLNALVEEVLQLF 472
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 319 EPTAEQNQQHIILHKNHE-PIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS-----IKISDNGKGVNKQQLSQ 392
Cdd:PRK11360 473 QTAGVQARVDFETELDNElPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSdgqvaVSIEDNGCGIDPELLKK 552
|
170 180 190
....*....|....*....|....*....|....*....
gi 916891199 393 LTKRFYRSdlaRQKdGFGLGLATVKAICDRHHFTLTLQS 431
Cdd:PRK11360 553 IFDPFFTT---KAK-GTGLGLALSQRIINAHGGDIEVES 587
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
245-413 |
9.49e-12 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 66.43 E-value: 9.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLTRLR----LHLEKEAI---KQPSLGIAIEQLESVLHTFDAMLKLTRLEhgqfPLKLEPVNGFTLMSDIIDI 317
Cdd:COG5806 208 IAHEVRNPLTVVRgfiqLLQEPELSdekRKQYIRIALEELDRAEAIITDYLTFAKPQ----PEKLEKIDVSEELEHVIDV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 318 LEPTAeqNQQHIILHKNHEPIF--EGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLS 391
Cdd:COG5806 284 LSPYA--NMNNVEIQTELEPGLyiEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKnkviISIKDTGVGMTKEQLE 361
|
170 180
....*....|....*....|..
gi 916891199 392 QLTKRFYRSdlarQKDGFGLGL 413
Cdd:COG5806 362 RLGEPYFST----KEKGTGLGT 379
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
35-441 |
1.88e-11 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 65.81 E-value: 1.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 35 LCIVLIYQLLLGEQTRQVERQLNAEQVRIEGLANKFDKASFFKQLNVFRNEGDILIFWQNDETQSQGLSFFPSDIPKLPK 114
Cdd:COG2972 31 LIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 115 TVEFPVLDTQRGQIRLLTTGIVKTKHGKVVIATATEHLSRLITEFKTIATWACLLSLVLTCVFGYIFARRHLRRVNYFNN 194
Cdd:COG2972 111 LLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKK 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 195 VAEQVQKGDLSarVVHKQKGDEFVTLAKHINTMLQSIEENFALVQGITDNIA-------------HDLKNPLTRLRLHLE 261
Cdd:COG2972 191 AMKKVEKGDLV--RLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKeaelkalqaqinpHFLFNTLNSIRWLAE 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 262 KEAIKQpslgiAIEQLESVLHTFDAMLKLTRLEHgqfPLKLEpvngFTLMSDIIDILEPTAEQNqqhIILHKNHEPIFEG 341
Cdd:COG2972 269 LEDPEE-----AEEMLEALSKLLRYSLSKGDELV---TLEEE----LELIKSYLEIQKLRFGDR---LEVEIEIDEELLD 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 342 DK--NLLFQacyNLLQNAIKYA----GNHAKITITLSKSS----IKISDNGKGVNKQQLSQLtkrfyRSDLARQKDGFGL 411
Cdd:COG2972 334 LLipKLILQ---PLVENAIEHGiepkEGGGTIRISIRKEGdrlvITVEDNGVGMPEEKLEKL-----LEELSSKGEGRGI 405
|
410 420 430
....*....|....*....|....*....|....
gi 916891199 412 GLATVKAICDRHH---FTLTLQSDEN-GFSSTIS 441
Cdd:COG2972 406 GLRNVRERLKLYYgeeYGLEIESEPGeGTTVTIR 439
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
245-427 |
2.60e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 64.97 E-value: 2.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLT-------RLRLHLEKEAIKQPSLGIA--IEQLESVLHTFDAM----LKLTRLEHGQFPLKLEPVNGFTLM 311
Cdd:PRK09303 158 LAHDLRTPLTaaslaleTLELGQIDEDTELKPALIEqlQDQARRQLEEIERLitdlLEVGRTRWEALRFNPQKLDLGSLC 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 312 SDIIDILEPTAEQNQQHIILH-KNHEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITI-----TLSKSSIKISDNGKGV 385
Cdd:PRK09303 238 QEVILELEKRWLAKSLEIQTDiPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLsmlhrTTQKVQVSICDTGPGI 317
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 916891199 386 NKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICDRH----------------HFTL 427
Cdd:PRK09303 318 PEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHygqiwvdsepgqgscfHFTL 375
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
339-435 |
2.94e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 60.72 E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 339 FEGDKNLLFQACYNLLQNAIKYAgnHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQkdGFGLGLA 414
Cdd:cd16954 31 FPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDgglhLIVDDDGPGVPESQRSKIFQRGQRLDEQRP--GQGLGLA 106
|
90 100
....*....|....*....|.
gi 916891199 415 TVKAICDRHHFTLTLQSDENG 435
Cdd:cd16954 107 IAKEIVEQYGGELSLSDSPLG 127
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
127-431 |
3.24e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 62.01 E-value: 3.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 127 QIRLLTTGIVKTKHGKVViaTATEHLSRLITEFKTIATWACLLSLVLTCVFGYIFARRHL-RRVNYFNNVAEQVQKGDLS 205
Cdd:COG4192 294 QLRTQISGLVGNSREQLV--ALNQETAQLVQQSGILLLAIALLSLLLAVLINYFYVRRRLvKRLNALSDAMAAIAAGDLD 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 206 ARV----------------VHKQK------------GDEFVTLAKHINTMLQSIEENFALVQGIT-DNIAHDLKNPLTRL 256
Cdd:COG4192 372 VPIpvdgndeigriarllrVFRDQaiektqeleteiEERKRIEKNLRQTQDELIQAAKMAVVGQTmTSLAHELNQPLNAM 451
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 257 RLHL--EKEAIKQPSLGIAIEQLESVLHTFDAMLKL-TRLEhgQFPLKLE-PVNGFTLMSDIIDILEPTAEQNQ-QHIIL 331
Cdd:COG4192 452 SMYLfsAKKALEQENYAQLPTSLDKIEGLIERMDKIiKSLR--QFSRKSDtPLQPVDLRQVIEQAWELVESRAKpQQITL 529
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 332 HKNHEPIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNkqQLSQLTKRFYRSdlarqKD 407
Cdd:COG4192 530 HIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAenlrVAISDNGNGWP--LVDKLFTPFTTT-----KE 602
|
330 340
....*....|....*....|....*
gi 916891199 408 -GFGLGLATVKAICDRHHFTLTLQS 431
Cdd:COG4192 603 vGLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-427 |
4.61e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 56.70 E-value: 4.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 342 DKNLLFQACYNLLQNAIKYAGNHAKITITLSKS----SIKISDNGKGVNKQQLSQLTKRFYRSDLARQK--DGFGLGLAT 415
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTpqevRLDVEDSAPGVSDDQLARLFERFYRVESSRNRasGGSGLGLAI 80
|
90
....*....|..
gi 916891199 416 VKAICDRHHFTL 427
Cdd:cd16946 81 CHNIALAHGGTI 92
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
245-433 |
7.41e-10 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 60.57 E-value: 7.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLTRLRLHLEKEAIKQPSLGIAiEQLESVL--------HTFDAMLKLTRLEHgqfpLKLEPVNGFTLMSDIID 316
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFAERAPAGGEA-HQLAQVMakeadrlnRVVSELLELVKPTH----LALQAVDLNDLINHSLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 317 ILEPTAEQNQQHIILHKNHE-PIFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLS 391
Cdd:PRK10364 319 LVSQDANSREIQLRFTANDTlPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGagvkISVTDSGKGIAADQLE 398
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 916891199 392 QLTKRFYRSdlarQKDGFGLGLATVKAICDRHHFTLTLQSDE 433
Cdd:PRK10364 399 AIFTPYFTT----KAEGTGLGLAVVHNIVEQHGGTIQVASQE 436
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-435 |
6.17e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 53.23 E-value: 6.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 342 DKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYrsDLAR---QKDGFGLGLA 414
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTegieLLVFDEGSGIPDYALNRVFERFY--SLPRphsGQKSTGLGLA 78
|
90 100
....*....|....*....|.
gi 916891199 415 TVKAICDRHHFTLTLQSDENG 435
Cdd:cd16945 79 FVQEVAQLHGGRITLRNRPDG 99
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-435 |
1.66e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 51.94 E-value: 1.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 346 LFQACYNLLQNAIKYAGN--HAKITITLSKS----SIKISDNGKGVNKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAI 419
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPrrPPRIEVGAEDVgeewTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80
|
90
....*....|....*.
gi 916891199 420 CDRHHFTLTLQSDENG 435
Cdd:cd16921 81 IERHGGRIWLESEPGE 96
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-423 |
2.49e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 51.66 E-value: 2.49e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 916891199 352 NLLQNAIKYAGNHAKITITLSKSS--IKISDNGKGVNKQQLSQLTKRFYRSDLARQKD--GFGLGLATVKAICDRH 423
Cdd:cd16939 7 NLLRNALRYAHRTVRIALLVSGGRltLIVEDDGPGIPAAARERVFEPFVRLDPSRDRAtgGFGLGLAIVHRVALWH 82
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
14-331 |
7.13e-08 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 54.73 E-value: 7.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 14 RVSSVWRLTLAFATITSVVLVLCIVLIYQLLLGEQTRQVERQLNAEQVRIEGLANKFDKASFFKQLNVFRNEGDILIFWQ 93
Cdd:COG2770 65 VLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 94 NDETQSQGLSFFPSDIPKLPKTVEFPVLDTQRGQIRLLTTGIVKTKHGKVVIATATEHLSRLITEFKTIATWACLLSLVL 173
Cdd:COG2770 145 LGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 174 TCVFGYIFARRHLRRVNYFNNVAEQVQKGDLSARvVHKQKGDEFVTLAKHINTMLQSIEENFALVQgITDNIAHDLKNPL 253
Cdd:COG2770 225 ALLLALLLARRITRPLRRLAEAARRIAAGDLDVR-IPVSRKDEIGELARAFNRMADSLRESIEEAE-EEEELAEAELARL 302
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 916891199 254 TRLRLHLEKEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEHGQFPLKLEPVNGFTLMSDIIDILEPTAEQNQQHIIL 331
Cdd:COG2770 303 LEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALE 380
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
120-246 |
1.61e-07 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 53.49 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 120 VLDTQRGQIRLLTTGIVKTKHGKVVIATATEHLSRLITEFKTIATWACLLSLVLTCVFGYIFARRHLRRVNYFNNVAEQV 199
Cdd:COG0840 141 AALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERI 220
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 916891199 200 QKGDLSARVVHKQKgDEFVTLAKHINTMLQSIEENFALVQGITDNIA 246
Cdd:COG0840 221 AEGDLTVRIDVDSK-DEIGQLADAFNRMIENLRELVGQVRESAEQVA 266
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
352-435 |
2.12e-07 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 52.93 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 352 NLLQNAI----KYAGNHAKITITLSKS----SIKISDNGKGVNKQQLSQLTKRFYRSdlaRQKDGFGLGLATVKAICDRH 423
Cdd:COG3290 288 NLLDNAIeaveKLPEEERRVELSIRDDgdelVIEVEDSGPGIPEELLEKIFERGFST---KLGEGRGLGLALVKQIVEKY 364
|
90
....*....|..
gi 916891199 424 HFTLTLQSDENG 435
Cdd:COG3290 365 GGTIEVESEEGE 376
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
143-295 |
2.19e-07 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 52.96 E-value: 2.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 143 VVIATATEHLSRLITEFKTIATWACLLSLVLTCVFGYIFARRHLRRVNYFNNVAEQVQKGDLSARVVHKQKgDEFVTLAK 222
Cdd:COG3850 100 LLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGR-DELGTLAR 178
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 916891199 223 HINTMLQSIEENFALVQGITDNIAHDLKNPLTRLRLHLEKEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEH 295
Cdd:COG3850 179 AFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAES 251
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
245-431 |
3.34e-07 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 52.81 E-value: 3.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 245 IAHDLKNPLTRLRLHLE---------KEAIKQPSLGIAIEQleSVLHTFDAMLKLTRLEHGQFPLKLEPVNGFTLMSDII 315
Cdd:PRK09959 719 MSHEIRTPISSIMGFLEllsgsglskEQRVEAISLAYATGQ--SLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTC 796
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 316 DILEPTAEQNQQHIILHKNHEP--IFEGDKNLLFQACYNLLQNAIKYAGNHA-KITITL-----SKSSIKIS--DNGKGV 385
Cdd:PRK09959 797 HSFGAIAASKSIALSCSSTFPDhyLVKIDPQAFKQVLSNLLSNALKFTTEGAvKITTSLghiddNHAVIKMTimDSGSGL 876
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 916891199 386 NKQQLSQLTKRFYRSDLARQKDGFGLGLATVKAICDRHHFTLTLQS 431
Cdd:PRK09959 877 SQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLES 922
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-434 |
6.76e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 48.28 E-value: 6.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 337 PIF-EGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQK--DGF 409
Cdd:cd16947 11 PIYaNANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEkhvyIDIWDKGKGISETEKDHVFERLYTLEDSRNSakQGN 90
|
90 100
....*....|....*....|....*
gi 916891199 410 GLGLATVKAICDRHHFTLTLQSDEN 434
Cdd:cd16947 91 GLGLTITKRLAESMGGSIYVNSKPY 115
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-434 |
1.01e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 47.28 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 353 LLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQ-KDGFGLGLATVKAICDRHHFTL 427
Cdd:cd16948 13 IVSNALKYSKQGGKIEIYSETNEqgvvLSIKDFGIGIPEEDLPRVFDKGFTGENGRNfQESTGMGLYLVKKLCDKLGHKI 92
|
....*..
gi 916891199 428 TLQSDEN 434
Cdd:cd16948 93 DVESEVG 99
|
|
| HAMP |
pfam00672 |
HAMP domain; |
180-233 |
1.51e-06 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 44.92 E-value: 1.51e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 916891199 180 IFARRHLRRVNYFNNVAEQVQKGDLSARVVHKQKgDEFVTLAKHINTMLQSIEE 233
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGR-DEIGELARAFNQMAERLRE 53
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
352-431 |
1.58e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 46.72 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 352 NLLQNAIKYAgNHAKITITLSKSSIK---------ISDNGKGVNKQQLSQLTKRFYRSD--LARQKDGFGLGLATVKAIC 420
Cdd:cd16922 7 NLLGNAIKFT-EEGEVTLRVSLEEEEedgvqlrfsVEDTGIGIPEEQQARLFEPFSQADssTTRKYGGTGLGLAISKKLV 85
|
90
....*....|.
gi 916891199 421 DRHHFTLTLQS 431
Cdd:cd16922 86 ELMGGDISVES 96
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
162-423 |
2.06e-06 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 50.06 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 162 IATWAC---LLSLVLTCVFGYIfARRHLrrvnyfnnvaeQVQKGDLSARVVHKQKGDEFVTLAkhintmlqsieenfalv 238
Cdd:PRK13837 404 LRPPAGelqLLELALDCLAHAI-ERRRL-----------ETERDALERRLEHARRLEAVGTLA----------------- 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 239 qgitDNIAHDLKNPLTRLRLHLEKEAIKQPSLGIAIEQLESVLHT-------FDAMLKLTRLEhgqfPLKLEPVNGFTLM 311
Cdd:PRK13837 455 ----SGIAHNFNNILGAILGYAEMALNKLARHSRAARYIDEIISAgararliIDQILAFGRKG----ERNTKPFDLSELV 526
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 312 SDIIDILE----PTAEqnqqhIILHKNHEP-IFEGDKNLLFQACYNLLQNAIKYAGNHAKITITLSKSS----------- 375
Cdd:PRK13837 527 TEIAPLLRvslpPGVE-----LDFDQDQEPaVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlrapkvlshgv 601
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 916891199 376 --------IKISDNGKGVNKQQLSQLTKRFY--RSDlarqkdGFGLGLATVKAICDRH 423
Cdd:PRK13837 602 lppgryvlLRVSDTGAGIDEAVLPHIFEPFFttRAG------GTGLGLATVHGIVSAH 653
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
345-431 |
2.14e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 46.26 E-value: 2.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 345 LLFQACYNLLQNAIKYAGNHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLArqKDGFGLGLATVKAIC 420
Cdd:cd16943 3 QLNQVLLNLLVNAAQAMEGRGRITIRTWAHVdqvlIEVEDTGSGIDPEILGRIFDPFFTTKPV--GEGTGLGLSLSYRII 80
|
90
....*....|.
gi 916891199 421 DRHHFTLTLQS 431
Cdd:cd16943 81 QKHGGTIRVAS 91
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
183-233 |
2.89e-06 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 44.16 E-value: 2.89e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 916891199 183 RRHLRRVNYFNNVAEQVQKGDLSARVvHKQKGDEFVTLAKHINTMLQSIEE 233
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRL-PVDGRDEIGELARAFNEMADRLEE 50
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
352-429 |
8.97e-06 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 44.41 E-value: 8.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 352 NLLQNAIKYAGNHAKITITLSKSS-----IKISDNGKGVNKQQLSQLTKRFYR--SDLARQKDGFGLGLATVKAICDRHH 424
Cdd:cd16925 11 NLLSNAFKFTPDGGRIRCILEKFRlnrflLTVSDSGPGIPPNLREEIFERFRQgdGSSTRAHGGTGLGLSIVKEFVELHG 90
|
....*
gi 916891199 425 FTLTL 429
Cdd:cd16925 91 GTVTV 95
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
186-231 |
2.13e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 41.66 E-value: 2.13e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 916891199 186 LRRVNYFNNVAEQVQKGDLSARVVHKQKgDEFVTLAKHINTMLQSI 231
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRSK-DEIGELARAFNQMAERL 45
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-435 |
2.67e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 42.91 E-value: 2.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 342 DKNLLFQACYNLLQNAIKYA----GNHAKITITLSKS-----SIKISDNGKGVNKQQLSQLTKRFYRSdlaRQKdGFGLG 412
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIegrpSDVGEVRIRVEADqdgriVLIVCDNGKGFPREMRHRATEPYVTT---RPK-GTGLG 76
|
90 100
....*....|....*....|...
gi 916891199 413 LATVKAICDRHHFTLTLQSDENG 435
Cdd:cd16944 77 LAIVKKIMEEHGGRISLSNREAG 99
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
244-296 |
7.32e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 40.66 E-value: 7.32e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 916891199 244 NIAHDLKNPLTRLRLHLE------KEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEHG 296
Cdd:pfam00512 8 NLSHELRTPLTAIRGYLEllrdekLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
244-296 |
1.52e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 39.86 E-value: 1.52e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 916891199 244 NIAHDLKNPLTRLRLHLE------KEAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEHG 296
Cdd:smart00388 8 NLSHELRTPLTAIRGYLEllldteLSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
237-424 |
1.72e-04 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 43.53 E-value: 1.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 237 LVQGItdniAHDLKNPLTRLR--LHLEKEAIKQPSL----GIAIEQLESVLHTFDamlkltRLEHGQFPlklepvnGFTL 310
Cdd:PRK11073 133 LVRGL----AHEIKNPLGGLRgaAQLLSKALPDPALteytKVIIEQADRLRNLVD------RLLGPQRP-------GTHV 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 311 MSDIIDILEPTAE----QNQQHIILHKNHEPI---FEGDKNLLFQACYNLLQNAIKYAG-NHAKITI--------TLS-- 372
Cdd:PRK11073 196 TESIHKVAERVVQlvslELPDNVRLIRDYDPSlpeLAHDPDQIEQVLLNIVRNALQALGpEGGTITLrtrtafqlTLHge 275
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 916891199 373 ----KSSIKISDNGKGVNKQQLSQLtkrFYRSDLARQkDGFGLGLATVKAICDRHH 424
Cdd:PRK11073 276 ryrlAARIDIEDNGPGIPPHLQDTL---FYPMVSGRE-GGTGLGLSIARNLIDQHS 327
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
244-292 |
1.15e-03 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 37.19 E-value: 1.15e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 916891199 244 NIAHDLKNPLTRLRLHLE-------KEAIKQPSLGIAIEQLESVLHTFDAMLKLTR 292
Cdd:cd00082 10 NVSHELRTPLTAIRGALElleeellDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-435 |
1.64e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 37.76 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 348 QACYNLLQNAIKyAGNHA-----KITITLSKS-----SIKISDNGKGVNKQQLSQLTKRFYRSdlarQKDGFGLGLATVK 417
Cdd:cd16920 3 QVLINLVRNGIE-AMSEGgcerrELTIRTSPAddravTISVKDTGPGIAEEVAGQLFDPFYTT----KSEGLGMGLSICR 77
|
90
....*....|....*...
gi 916891199 418 AICDRHHFTLTLQSDENG 435
Cdd:cd16920 78 SIIEAHGGRLSVESPAGG 95
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
216-414 |
2.03e-03 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 40.39 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 216 EFVTLAKHINTMLQSIEENFALVQGITDNIAHDLKNPL----TRLR-LHLEKEAIKQPSLGIAIEQLESV-------LHT 283
Cdd:PRK10815 244 ELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLavlqSTLRsLRSGKQMSVEQAEPIMLEQISRIsqqigyyLHR 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 284 FDAmlkltRLEHGQFPLKLEPVNGftLMSDIIDILEPTAEQNQQHIILHKNHEPIFEGDKNLLFQACYNLLQNAIKYAGN 363
Cdd:PRK10815 324 ASM-----RSEHNLLSRELHSVAP--LLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLE 396
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 916891199 364 HAKITITLSKSSIKI--SDNGKGVNKQQLSQLTKRFYRSDLARQKDGFGLGLA 414
Cdd:PRK10815 397 FVEISARQTDEHLHIvvEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVA 449
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
241-393 |
2.05e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 40.69 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 241 ITDNIAHDLKNPLTRLRLHLEK------EAIKQPSLGIAIEQLESVLHTFDAMLKLTRLEHGQFPLKLEPVNGFTLMSDI 314
Cdd:PRK10618 453 FLQNIGDELKQPLQSLAQLAAQlrqtsdEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDEV 532
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 315 IDILEPTAEQN--QQHIILHKNHEPIFEGDKNLLFQACYNLLQNAIKYAgNHAKITITLSKS-------SIKISDNGKGV 385
Cdd:PRK10618 533 LPEVLPAIKRKglQLLIHNHLKAEQLRIGDRDALRKILLLLLNYAITTT-AYGKITLEVDQDesspdrlTIRILDTGAGV 611
|
....*...
gi 916891199 386 NKQQLSQL 393
Cdd:PRK10618 612 SIKELDNL 619
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-423 |
4.26e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 36.78 E-value: 4.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916891199 346 LFQACYNLLQNAIKYA-GNHAKITITLSKSS----IKISDNGKGVNKQQLSQLTKRFYRSDLARQKDG--FGLGLATVKA 418
Cdd:cd16953 1 LGQVLRNLIGNAISFSpPDTGRITVSAMPTGkmvtISVEDEGPGIPQEKLESIFDRFYTERPANEAFGqhSGLGLSISRQ 80
|
....*
gi 916891199 419 ICDRH 423
Cdd:cd16953 81 IIEAH 85
|
|
| |
