NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|917152187|ref|WP_051758899|]
View 

GNAT family N-acetyltransferase [Bacillus manliponensis]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514829)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|10940244|9175471
SCOP:  3000403

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 153-275 1.70e-55

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


:

Pssm-ID: 436212  Cd Length: 123  Bit Score: 175.17  E-value: 1.70e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  153 VRKLDEEANGVDRSEFLKVRIKQAKQTVVVKNRSGTIVGFGLSIQTPANLILGPIVAFCEEVAVLIIYELSHRHNGRLRI 232
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 917152187  233 DTPENKVELTSFLQKKGFYKVAQPPIMVRNGSTLLQRNENLYG 275
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 50-137 1.39e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 66.17  E-value: 1.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  50 KVIASAAIIPYAGELASIGMVIVHPNYRGLQLGKRVMEACIQSVGDD--KQIMLITTPDGKPMYEKLGFQVVSSVHKYLC 127
Cdd:COG1246   38 EIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEIDKEDLPYA 117

                         90
                 ....*....|
gi 917152187 128 DEFICERITF 137
Cdd:COG1246  118 KVWQRDSVVM 127
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 153-275 1.70e-55

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 175.17  E-value: 1.70e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  153 VRKLDEEANGVDRSEFLKVRIKQAKQTVVVKNRSGTIVGFGLSIQTPANLILGPIVAFCEEVAVLIIYELSHRHNGRLRI 232
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 917152187  233 DTPENKVELTSFLQKKGFYKVAQPPIMVRNGSTLLQRNENLYG 275
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 50-137 1.39e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 66.17  E-value: 1.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  50 KVIASAAIIPYAGELASIGMVIVHPNYRGLQLGKRVMEACIQSVGDD--KQIMLITTPDGKPMYEKLGFQVVSSVHKYLC 127
Cdd:COG1246   38 EIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEIDKEDLPYA 117

                         90
                 ....*....|
gi 917152187 128 DEFICERITF 137
Cdd:COG1246  118 KVWQRDSVVM 127
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 5-116 7.47e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 7.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187    5 LQLLNEQHIEQLIQLSQSVDWDYDRFEIETILSV---GKVYGYIhesrkviaSAAIIPYAGELASIGMVIVHPNYRGLQL 81
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAeedGELVGFA--------SLSIIDDEPPVGEIEGLAVAPEYRGKGI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 917152187   82 GKRVMEACIQ---SVGDDKqIMLITTPDGKP---MYEKLGF 116
Cdd:pfam00583  77 GTALLQALLEwarERGCER-IFLEVAADNLAaiaLYEKLGF 116
Eis COG4552
Predicted acetyltransferase [General function prediction only];
3-192 1.31e-05

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 46.05  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187   3 HSLQLLNEQHIEQLIQL-SQSVDWDYDRFEIET---ILSVGKVYGYIHESRkVIASAAIIPY----AGEL---ASIGMVI 71
Cdd:COG4552    1 MEIRPLTEDDLDAFARLlAYAFGPEPDDEELEAyrpLLEPGRVLGVFDDGE-LVGTLALYPFtlnvGGARvpmAGITGVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  72 VHPNYRGLQLGKRVMEACIQSVGDDKQIMLITTPDGKPMYEKLGFQVVSSVHKYlcdEFICERITFHEY---EITNYEEK 148
Cdd:COG4552   80 VAPEHRRRGVARALLREALAELRERGQPLSALYPFEPGFYRRFGYELAGDRRRY---TIPPESLPLRPDapgRVRRVDPD 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 917152187 149 DFLHVRKLDEEA----NG-VDRSE-----FLKVRIKQAKQTVVVKNRSGTIVGF 192
Cdd:COG4552  157 DAELLAALYERFarrrPGaLDRDEawwerVLRDLGGEPLRAAVHYDEDGEPDGY 210
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 47-116 4.87e-05

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 42.38  E-value: 4.87e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 917152187  47 ESRKVIASAAI------IPYAGELASIGMVIVHPNYRGLQLGKRVMEACI---QSVGDDKQImLITTPDGKPMYEKLGF 116
Cdd:PLN02706  62 ASGRIIATGSVfverkfIRNCGKVGHIEDVVVDSAARGKGLGKKIIEALTehaRSAGCYKVI-LDCSEENKAFYEKCGY 139
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 50-91 1.92e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.10  E-value: 1.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 917152187  50 KVIASAAIIPY--AGELASIGMVIVHPNYRGLQLGKRVMEACIQ 91
Cdd:cd04301    9 EIVGFASLSPDgsGGDTAYIGDLAVLPEYRGKGIGSALLEAAEE 52
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 153-275 1.70e-55

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 175.17  E-value: 1.70e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  153 VRKLDEEANGVDRSEFLKVRIKQAKQTVVVKNRSGTIVGFGLSIQTPANLILGPIVAFCEEVAVLIIYELSHRHNGRLRI 232
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 917152187  233 DTPENKVELTSFLQKKGFYKVAQPPIMVRNGSTLLQRNENLYG 275
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 50-137 1.39e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 66.17  E-value: 1.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  50 KVIASAAIIPYAGELASIGMVIVHPNYRGLQLGKRVMEACIQSVGDD--KQIMLITTPDGKPMYEKLGFQVVSSVHKYLC 127
Cdd:COG1246   38 EIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEIDKEDLPYA 117

                         90
                 ....*....|
gi 917152187 128 DEFICERITF 137
Cdd:COG1246  118 KVWQRDSVVM 127
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
50-129 1.30e-11

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 59.54  E-value: 1.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  50 KVIASAAIIPYAGELASIGMVIVHPNYRGLQLGKRVMEACIQSVGDD--KQIMLIT---TPDGKPMYEKLGFQVVSSVHK 124
Cdd:COG3393    1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARgaRTPFLYVdadNPAARRLYERLGFRPVGEYAT 80


                 ....*
gi 917152187 125 YLCDE 129
Cdd:COG3393   81 VLFRK 85
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
50-122 1.44e-10

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 57.89  E-value: 1.44e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 917152187  50 KVIASAAIIPYAGELASIGMVIVHPNYRGLQLGKRVMEACIQSVGD--DKQIMLITTPDGKPMYEKLGFQVVSSV 122
Cdd:COG2153   44 ELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARErgARRIVLSAQAHAVGFYEKLGFVPVGEE 118
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
39-131 1.61e-10

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 58.17  E-value: 1.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  39 GKVYGYIHesrkviASAAIIPYAGELASIGMVIVHPNYRGLQLGKRVMEACIQSVGDD--KQIMLITTPDGKPMYEKLGF 116
Cdd:COG3153   48 GEIVGHVA------LSPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERgaRAVVLLGDPSLLPFYERFGF 121

                         90
                 ....*....|....*
gi 917152187 117 QVVSSVHKYLCDEFI 131
Cdd:COG3153  122 RPAGELGLTLGPDEV 136
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 55-128 1.33e-08

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 51.19  E-value: 1.33e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 917152187  55 AAIIPYAGELASIGMVIVHPNYRGLQLGKRVMEACIQSVGDD--KQIMLITTPDGKP---MYEKLGFQVVSSVHKYLCD 128
Cdd:COG0456    4 LLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERgaRRLRLEVREDNEAaiaLYEKLGFEEVGERPNYYGD 82
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 5-116 7.47e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 49.82  E-value: 7.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187    5 LQLLNEQHIEQLIQLSQSVDWDYDRFEIETILSV---GKVYGYIhesrkviaSAAIIPYAGELASIGMVIVHPNYRGLQL 81
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAeedGELVGFA--------SLSIIDDEPPVGEIEGLAVAPEYRGKGI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 917152187   82 GKRVMEACIQ---SVGDDKqIMLITTPDGKP---MYEKLGF 116
Cdd:pfam00583  77 GTALLQALLEwarERGCER-IFLEVAADNLAaiaLYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 45-118 1.33e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 48.22  E-value: 1.33e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 917152187   45 IHESRKVIASAAIIPYAGELASIG-MVIVHPNYRGLQLGKRVMEACIQSVGDD--KQIMLITTPDGKPMYEKLGFQV 118
Cdd:pfam13508   8 AEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGgiKLLELETTNRAAAFYEKLGFEE 84
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 50-131 2.80e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 45.81  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  50 KVIASAAIIPYAGELASIGMVIVHPNYRGLQLGKRVMEACIQ-SVGDDKQIMLITT----PDGKPMYEKLGFQVVSSVHK 124
Cdd:COG0454   44 EPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEwARERGCTALELDTldgnPAAIRFYERLGFKEIERYVA 123


                 ....*..
gi 917152187 125 YLCDEFI 131
Cdd:COG0454  124 YVGGEFE 130
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 67-122 3.74e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 45.34  E-value: 3.74e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187   67 IGMVIVHPNYRGLQLGKRVMEACIQSVGDDK----QIMLITTPDGKPMYEKLGFQVVSSV 122
Cdd:pfam13673  54 ISLLFVDPDYQGQGIGKALLEAVEDYAEKDGiklsELTVNASPYAVPFYEKLGFRATGPE 113
Eis COG4552
Predicted acetyltransferase [General function prediction only];
3-192 1.31e-05

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 46.05  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187   3 HSLQLLNEQHIEQLIQL-SQSVDWDYDRFEIET---ILSVGKVYGYIHESRkVIASAAIIPY----AGEL---ASIGMVI 71
Cdd:COG4552    1 MEIRPLTEDDLDAFARLlAYAFGPEPDDEELEAyrpLLEPGRVLGVFDDGE-LVGTLALYPFtlnvGGARvpmAGITGVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  72 VHPNYRGLQLGKRVMEACIQSVGDDKQIMLITTPDGKPMYEKLGFQVVSSVHKYlcdEFICERITFHEY---EITNYEEK 148
Cdd:COG4552   80 VAPEHRRRGVARALLREALAELRERGQPLSALYPFEPGFYRRFGYELAGDRRRY---TIPPESLPLRPDapgRVRRVDPD 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 917152187 149 DFLHVRKLDEEA----NG-VDRSE-----FLKVRIKQAKQTVVVKNRSGTIVGF 192
Cdd:COG4552  157 DAELLAALYERFarrrPGaLDRDEawwerVLRDLGGEPLRAAVHYDEDGEPDGY 210
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 47-116 4.87e-05

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 42.38  E-value: 4.87e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 917152187  47 ESRKVIASAAI------IPYAGELASIGMVIVHPNYRGLQLGKRVMEACI---QSVGDDKQImLITTPDGKPMYEKLGF 116
Cdd:PLN02706  62 ASGRIIATGSVfverkfIRNCGKVGHIEDVVVDSAARGKGLGKKIIEALTehaRSAGCYKVI-LDCSEENKAFYEKCGY 139
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
47-124 2.13e-04

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 40.75  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187  47 ESRKVIASAAIIPYAGELASIG----MVIVHPNYRGLQLGKRVMEACIQSVGDD--KQIMLITTPDGKPM---YEKLGFQ 117
Cdd:COG1247   59 EDGEVVGFASLGPFRPRPAYRGtaeeSIYVDPDARGRGIGRALLEALIERARARgyRRLVAVVLADNEASialYEKLGFE 138


                 ....*..
gi 917152187 118 VVSSVHK 124
Cdd:COG1247  139 EVGTLPE 145
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 8-116 2.62e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 39.86  E-value: 2.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187    8 LNEQHIEQLIQLSQSV----DWDYDRFEIETILSVGKVYGyIHESRKVIASAAIIPYA----GEL---ASIGMVIVHPNY 76
Cdd:pfam13527   4 LTEDEFDEVLRLLEYAfqdeDSPELREYFRPLLEEGRVLG-AFDDGELVSTLALYPFElnvpGKTlpaAGITGVATYPEY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 917152187   77 RGLQLGKRVMEACIQSVGDDKQIMLITTPDGKPMYEKLGF 116
Cdd:pfam13527  83 RGRGVMSRLLRRSLEEMRERGVPLSFLYPSSYPIYRRFGY 122
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 41-118 1.53e-03

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 36.92  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917152187   41 VYGyIHESRKVIASAAII-PYAGELasiGMVIVHPNYRGLQLGKRVMEACIQSV---GDDkqIMLITTPDGKP---MYEK 113
Cdd:pfam08445   1 VLG-IYRGDTGELAAWCLrLPGGEL---GALQTLPEHRRRGLGSRLVAALARGIaerGIT--PFAVVVAGNTPsrrLYEK 74


                  ....*
gi 917152187  114 LGFQV 118
Cdd:pfam08445  75 LGFRK 79
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 50-91 1.92e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 36.10  E-value: 1.92e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 917152187  50 KVIASAAIIPY--AGELASIGMVIVHPNYRGLQLGKRVMEACIQ 91
Cdd:cd04301    9 EIVGFASLSPDgsGGDTAYIGDLAVLPEYRGKGIGSALLEAAEE 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH