|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-581 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 1096.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 1 MHSLSFPRRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRL 80
Cdd:PRK06354 1 MSLRDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 81 GKFACGSITLKPGEHFILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRLKGDLSCRVVVGGVLSS 160
Cdd:PRK06354 81 GRFEDGPIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 161 NKGVNFPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELI-ASAGKSIPVIAKIEKHEAIEEMEAIL 239
Cdd:PRK06354 161 KKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIeEHNGKHIPIIAKIEKQEAIDNIDAIL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 240 SLCDGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNE 319
Cdd:PRK06354 241 ELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 320 TAVGHYPIEAVATMARIAERIEREQINSA---ARSNNKQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPK 396
Cdd:PRK06354 321 TAAGDYPVEAVQTMATIAVRIEKDLPYRDilsKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 397 TPILAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKVEVVKS 476
Cdd:PRK06354 401 TPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 477 LLGKGTGIGQGVASGRARVAHNAREVGSFSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIVGV 556
Cdd:PRK06354 481 VVAKGQGIGRKSVSGKARVAKTAAEVAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGV 560
|
570 580
....*....|....*....|....*
gi 917763701 557 KDATKIIREGVIISLDAQRGLIYSG 581
Cdd:PRK06354 561 KNATSLIKDGQIITVDAARGVVYSG 585
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
8-474 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 783.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 ITLKPGEHFILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDrlKGDLSCRVVVGGVLSSNKGVNFP 167
Cdd:COG0469 83 VELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVE--GDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 168 NVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLCDGVMV 247
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 248 ARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGHYPI 327
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 328 EAVATMARIAERIERE----QINSAARSNNKQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTPILAVT 403
Cdd:COG0469 321 EAVETMARIAEEAEKSldyrRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 917763701 404 PHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKVEVV 474
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
8-471 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 588.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 ITLKPGEHFILTSRD--VECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDrlKGDLSCRVVVGGVLSSNKGVN 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDDikGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVE--GDKVICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 166 FPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAG-KSIPVIAKIEKHEAIEEMEAILSLCDG 244
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 245 VMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGH 324
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 325 YPIEAVATMARIAERIE-----REQINSAARS-NNKQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTP 398
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEkalayLTNFNDRKNSdPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 917763701 399 ILAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQTF-QVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKV 471
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDEEPSDTDARvNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
8-474 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 520.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 -ITLKPGEHFILTSRD--VECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRLKGdLSCRVVVGGVLSSNKGV 164
Cdd:cd00288 82 dISLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKT-LVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 165 NFPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLCDG 244
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 245 VMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGH 324
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 325 YPIEAVATMARIAERIER--EQINSAARSNNKQSIPN----AISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTP 398
Cdd:cd00288 321 YPVEAVKAMARICLEAEKalSHRVLFNEMRRLTPRPTstteAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 399 ILAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQT-----FQVAMNLAQENNLLADGDLVVMTAGtLQGVAGSTDLIKVEV 473
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEEPKPGWQEdtdarLKAAVNVAKEKGLLKKGDLVVVVQG-WPVGSGSTNTMRILT 479
|
.
gi 917763701 474 V 474
Cdd:cd00288 480 V 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
8-343 |
3.26e-139 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 407.91 E-value: 3.26e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 --ITLKPGEHFILTSRDV---ECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRLKGdLSCRVVVGGVLSSNK 162
Cdd:pfam00224 82 kdIELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 163 GVNFPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLC 242
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 243 DGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAV 322
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|.
gi 917763701 323 GHYPIEAVATMARIAERIERE 343
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKA 341
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-581 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 1096.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 1 MHSLSFPRRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRL 80
Cdd:PRK06354 1 MSLRDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 81 GKFACGSITLKPGEHFILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRLKGDLSCRVVVGGVLSS 160
Cdd:PRK06354 81 GRFEDGPIELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADGELHCKVLVGGVLSN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 161 NKGVNFPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELI-ASAGKSIPVIAKIEKHEAIEEMEAIL 239
Cdd:PRK06354 161 KKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIeEHNGKHIPIIAKIEKQEAIDNIDAIL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 240 SLCDGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNE 319
Cdd:PRK06354 241 ELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 320 TAVGHYPIEAVATMARIAERIEREQINSA---ARSNNKQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPK 396
Cdd:PRK06354 321 TAAGDYPVEAVQTMATIAVRIEKDLPYRDilsKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 397 TPILAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKVEVVKS 476
Cdd:PRK06354 401 TPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 477 LLGKGTGIGQGVASGRARVAHNAREVGSFSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIVGV 556
Cdd:PRK06354 481 VVAKGQGIGRKSVSGKARVAKTAAEVAKVNEGDILVTPSTDADMIPAIEKAAAIITEEGGLTSHAAVVGLRLGIPVIVGV 560
|
570 580
....*....|....*....|....*
gi 917763701 557 KDATKIIREGVIISLDAQRGLIYSG 581
Cdd:PRK06354 561 KNATSLIKDGQIITVDAARGVVYSG 585
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
8-474 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 783.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 ITLKPGEHFILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDrlKGDLSCRVVVGGVLSSNKGVNFP 167
Cdd:COG0469 83 VELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVE--GDEVVCEVVNGGVLSSRKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 168 NVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLCDGVMV 247
Cdd:COG0469 161 GVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEASDGIMV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 248 ARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGHYPI 327
Cdd:COG0469 241 ARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 328 EAVATMARIAERIERE----QINSAARSNNKQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTPILAVT 403
Cdd:COG0469 321 EAVETMARIAEEAEKSldyrRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALT 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 917763701 404 PHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKVEVV 474
Cdd:COG0469 401 PNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
8-464 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 605.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:PRK05826 4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFKEGK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 ITLKPGEHFIL-TSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDrlKGDLSCRVVVGGVLSSNKGVNF 166
Cdd:PRK05826 84 ITLKTGDKFTLdTDQKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVD--GDEVETEVKNGGPLSNNKGINI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 167 PNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKS-IPVIAKIEKHEAIEEMEAILSLCDGV 245
Cdd:PRK05826 162 PGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPhAKIIAKIERAEAVDNIDEIIEASDGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 246 MVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGHY 325
Cdd:PRK05826 242 MVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGKY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 326 PIEAVATMARIAERIERE-QINSAARSNNKQ--SIPNAISSAVSQIAEQL-GAAAIITLTKTGSTARNVSRFRPKTPILA 401
Cdd:PRK05826 322 PVEAVEAMARICKGAEKEfSINLSKHRLDRQfdRIDEAIAMSAMYAANHLkGVKAIVALTESGRTARLISRFRPGAPIFA 401
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 917763701 402 VTPHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGVAG 464
Cdd:PRK05826 402 VTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
8-471 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 588.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 ITLKPGEHFILTSRD--VECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDrlKGDLSCRVVVGGVLSSNKGVN 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDDikGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVE--GDKVICEVLNGGTLKSKKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 166 FPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAG-KSIPVIAKIEKHEAIEEMEAILSLCDG 244
Cdd:TIGR01064 159 LPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEASDG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 245 VMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGH 324
Cdd:TIGR01064 239 IMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 325 YPIEAVATMARIAERIE-----REQINSAARS-NNKQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTP 398
Cdd:TIGR01064 319 YPVEAVQMMAKIAKEAEkalayLTNFNDRKNSdPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAP 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 917763701 399 ILAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQTF-QVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKV 471
Cdd:TIGR01064 399 IIAVTPNERVARQLALYWGVFPFLVDEEPSDTDARvNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
8-474 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 576.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:PRK06247 5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFADGK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 ITLKPGEHFILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDrlKGDLSCRVVVGGVLSSNKGVNFP 167
Cdd:PRK06247 85 VQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACD--GDDVVCRVVEGGPVSDRKGVSLP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 168 NVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIasaGKSIPVIAKIEKHEAIEEMEAILSLCDGVMV 247
Cdd:PRK06247 163 GTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKII---GGRVPVMAKIEKPQAIDRLEAIVEASDAIMV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 248 ARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGHYPI 327
Cdd:PRK06247 240 ARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 328 EAVATMARIAERIERE-----QINsAARSNNKQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTPILAV 402
Cdd:PRK06247 320 EAVRTMARIIRQVERDptyppLIH-AQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILAL 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 917763701 403 TPHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKVEVV 474
Cdd:PRK06247 399 TPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYI 470
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
8-474 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 520.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 -ITLKPGEHFILTSRD--VECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRLKGdLSCRVVVGGVLSSNKGV 164
Cdd:cd00288 82 dISLKAGDKFLVTTDPaaKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKT-LVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 165 NFPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLCDG 244
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 245 VMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGH 324
Cdd:cd00288 241 IMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 325 YPIEAVATMARIAERIER--EQINSAARSNNKQSIPN----AISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTP 398
Cdd:cd00288 321 YPVEAVKAMARICLEAEKalSHRVLFNEMRRLTPRPTstteAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 399 ILAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQT-----FQVAMNLAQENNLLADGDLVVMTAGtLQGVAGSTDLIKVEV 473
Cdd:cd00288 401 IIAVTRNEQTARQLHLYRGVYPVLFEEPKPGWQEdtdarLKAAVNVAKEKGLLKKGDLVVVVQG-WPVGSGSTNTMRILT 479
|
.
gi 917763701 474 V 474
Cdd:cd00288 480 V 480
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
8-474 |
2.10e-156 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 456.44 E-value: 2.10e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 -ITLKPGEHFILTS-RDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDrlKGDLSCRVVVGGVLSSNKGVN 165
Cdd:PRK09206 82 dVSLKAGQTFTFTTdKSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAIT--GNEVICKVLNNGDLGENKGVN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 166 FPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKE-LIASAGKSIPVIAKIEKHEAIEEMEAILSLCDG 244
Cdd:PRK09206 160 LPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREhLKAHGGENIQIISKIENQEGLNNFDEILEASDG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 245 VMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGH 324
Cdd:PRK09206 240 IMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 325 YPIEAVATMARIAERIEReQINSAARSNN---KQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTPILA 401
Cdd:PRK09206 320 YPLEAVSIMATICERTDR-VMNSRLESNNdnrKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILA 398
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 917763701 402 VTPHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQgVAGSTDLIKVEVV 474
Cdd:PRK09206 399 LTTNEKTARQLVLSKGVVPQLVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALV-PSGTTNTASVHVL 470
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
272-582 |
7.07e-145 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 421.62 E-value: 7.07e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 272 ANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGHYPIEAVATMARIAERIER----EQINS 347
Cdd:COG3848 2 CNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEdleyREQRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 348 AARSNNKQSIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTPILAVTPHREVAQQLQLVWGVKPMLLLDLP 427
Cdd:COG3848 82 PRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 428 STSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKVEVVKSLLGKGTGIGQGVASGRARVAHNARE-VGSFS 506
Cdd:COG3848 162 STDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLAKGQGIGRGSVTGKAVVARSAEEaLEKFE 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 917763701 507 SGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIVGVKDATKIIREGVIISLDAQRGLIYSGI 582
Cdd:COG3848 242 EGDILVVPSTDAEFVPAIEKAAGIITEEGGLTSHAAIVGLELGIPVIVGAEGATEILKDGQVVTVDAERGVVYRGA 317
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
8-343 |
3.26e-139 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 407.91 E-value: 3.26e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGS 87
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 88 --ITLKPGEHFILTSRDV---ECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRLKGdLSCRVVVGGVLSSNK 162
Cdd:pfam00224 82 kdIELKAGDEMIVSTDAKykgACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKT-LVVEVLNGGVIGSRK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 163 GVNFPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLC 242
Cdd:pfam00224 161 GVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEAT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 243 DGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAV 322
Cdd:pfam00224 241 DGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 320
|
330 340
....*....|....*....|.
gi 917763701 323 GHYPIEAVATMARIAERIERE 343
Cdd:pfam00224 321 GNYPVEAVRMMHEICLEAEKA 341
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
8-471 |
1.31e-126 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 381.80 E-value: 1.31e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQ-LAFELNQPIGILQDLQGPKIRLGKFACG 86
Cdd:PTZ00066 38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREaAKARPNANLGILLDTKGPEIRTGFLKNH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 87 S-ITLKPGEHF-ILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVdrlkGD--LSCRVVVGGVLSSNK 162
Cdd:PTZ00066 118 KpITLKEGQTLkITTDYTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEV----HDdyIITKVLNNATIGERK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 163 GVNFPNVYLSVKALTDKDKKDLM-FGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSL 241
Cdd:PTZ00066 194 NMNLPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAE 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 242 CDGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETA 321
Cdd:PTZ00066 274 SDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETA 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 322 VGHYPIEAVATMARIAERIE-----REQINSAARSNNKQ-SIPNAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRP 395
Cdd:PTZ00066 354 NGKFPVEAVNIMAKICFEAEtcidyRVLYHAIHLAVPTPvSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRP 433
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 917763701 396 KTPILAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGVAGSTDLIKV 471
Cdd:PTZ00066 434 SCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKV 509
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
7-453 |
2.77e-125 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 378.55 E-value: 2.77e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 7 PRRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACG 86
Cdd:PLN02461 20 RPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFLKDG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 87 S-ITLKPG-EHFILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRLKGDLSCRVVVGGVLSSNKGV 164
Cdd:PLN02461 100 KpVQLKQGqEITITTDYSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTVRCRCENSAMLGERKNV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 165 NFPNVYLSVKALTDKDKKDLM-FGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLCD 243
Cdd:PLN02461 180 NLPGVVVDLPTLTEKDKEDILqWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDILAESD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 244 GVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVG 323
Cdd:PLN02461 260 AFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAG 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 324 HYPIEAVATMARIAERIEREQINSAARSN--NKQSIPNAI-----SSAVSQiAEQLGAAAIITLTKTGSTARNVSRFRPK 396
Cdd:PLN02461 340 AYPELAVKTMARICREAEASLDYGALFKEimRSAPLPMSPleslaSSAVRT-ANKVKASLIVVLTRGGTTARLVAKYRPA 418
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 917763701 397 TPILAV------TPHRE-------VAQQLQLVWGVKPMLL------LDLPSTSQTFQVAMNLAQENNLLADGDLVV 453
Cdd:PLN02461 419 VPILSVvvpeitTDSFDwscsdeaPARHSLIYRGLIPVLAegsakaTDSESTEEILEAAIEHAKKKGLCKPGDSVV 494
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
13-341 |
6.24e-108 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 328.06 E-value: 6.24e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 13 VATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLafelNQPIGILQDLQGPKIRLGKFACGSITLKP 92
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSL----DDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 93 GEHFILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRLKgdLSCRVVVGGVLSSNKGVNFPNVYLS 172
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDK--IETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 173 VKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIP-VIAKIEKHEAIEEMEAILSLCDGVMVARGD 251
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSPnLIAKIETMEAIENFQDICKEADGIMIARGD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 252 LGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGHYPIEAVA 331
Cdd:PRK06739 240 LGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESVS 319
|
330
....*....|
gi 917763701 332 TMARIAERIE 341
Cdd:PRK06739 320 TLRLVSEFAE 329
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
38-472 |
6.86e-105 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 323.93 E-value: 6.86e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 38 RLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFACGSITLKPGEHFILTSRDV---ECNQEISSISY 114
Cdd:PTZ00300 5 RMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAfadKGTKDKFYIDY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 115 PSLAQEVPEGSRILLDDGKVEMRVESVDRlKGDLSCRVVVGGVLSSNKGVNFPNVYLSVKALTDKDKKDLMFGLLWDVDW 194
Cdd:PTZ00300 85 QNLSKVVRPGGYIYIDDGILILHVQSHED-EQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQGVDM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 195 IALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLCDGVMVARGDLGVELPAEDVPILQKRLINTANQ 274
Cdd:PTZ00300 164 IFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILISKCNV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 275 LGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVGHYPIEAVATMARIAERIErEQINSAARSNN- 353
Cdd:PTZ00300 244 AGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQ-SAVNEYVFFNSi 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 354 --KQSIPNAI-----SSAVSQIAEqLGAAAIITLTKTGSTARNVSRFRPKTPILAVTPHREVAQQLQLVWGVKPML---- 422
Cdd:PTZ00300 323 kkLQPIPMSAeeavcSSAVNSVYE-TKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFfdae 401
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 917763701 423 -LLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAG--TLQGVAGSTDLIKVE 472
Cdd:PTZ00300 402 rLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHAdhKVKGYANQTRIILVS 454
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
5-476 |
5.50e-101 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 318.03 E-value: 5.50e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 5 SFPRRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQL-AFELNQPIGILQDLQGPKIRLGKF 83
Cdd:PLN02623 107 SVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYnAQSKDNVIAIMLDTKGPEVRSGDL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 84 AcGSITLKPGEHFILTSRDVECNQEISSISYPSLAQEVPEGSRILLDDGKVEMRVESvdRLKGDLSCRVVVGGVLSSNKG 163
Cdd:PLN02623 187 P-QPIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKS--KTSDSVKCEVVDGGELKSRRH 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 164 VNFPNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIASAGKSIPVIAKIEKHEAIEEMEAILSLCD 243
Cdd:PLN02623 264 LNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPNLHSIITASD 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 244 GVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVMLSNETAVG 323
Cdd:PLN02623 344 GAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHG 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 324 HYPIEAVATMARIAERIEREQINSAARSNNKQSIPNAIS----SAVSQIAEQLGaAAIITLTKTGSTARNVSRFRPKTPI 399
Cdd:PLN02623 424 KFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSemfaFHATMMANTLG-TSIIVFTRTGFMAILLSHYRPSGTI 502
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 917763701 400 LAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMNLAQENNLLADGDLVVMTAGTLQGV--AGSTDLIKVEVVKS 476
Cdd:PLN02623 503 FAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALVQSGRQPIwrSESTHHIQVRKVQA 581
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
8-462 |
2.74e-90 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 287.80 E-value: 2.74e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKF-ACG 86
Cdd:PLN02762 25 RRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLgGAS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 87 SITLKPGEHFILTSRDVECNQEISSIS--YPSLAQEVPEGSRILLDDGKVemRVESVDRLKGDLSCRVVVGGVLSSNKGV 164
Cdd:PLN02762 105 SAKAEDGEEWTFTVRKFDGSRPEFTIQvnYDGFAEDVKVGDELVVDGGMV--RFEVIEKIGPDVKCKCTDPGLLLPRANL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 165 NF-------PNVYLSVKALTDKDKKDLMFGLLWDVDWIALSFVRNPQDILEIKELIA--SAGKSIPVIAKIEKHEAIEEM 235
Cdd:PLN02762 183 TFwrdgslvRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAarSRDSDIGVIAKIESLDSLKNL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 236 EAILSLCDGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAILDGTDAVM 315
Cdd:PLN02762 263 EEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVRQRADALM 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 316 LSNETAVGHYPIEAVATMARIAERIE---REQINSAARSNNK--QSIPNAIS----SAVSQIAEQLGAAAIITLTKTGST 386
Cdd:PLN02762 343 LSGESAMGLYPEKALSVLRSVSLRMElwsREEKRHEALELPQlsSSLSDRISeeicNSAAKMANNLGVDAIFVYTKHGHM 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 387 ARNVSRFRPKTPILAVTPHREVAQQLQLVWGVKPMLLL---DLPST-SQTFqvamNLAQENNLLADGDLVVM-----TAG 457
Cdd:PLN02762 423 ASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLDfsdDMESNlNKTF----SLLKARGMIKSGDLVIAvsdltPSS 498
|
....*
gi 917763701 458 TLQGV 462
Cdd:PLN02762 499 MLQSI 503
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
3-453 |
3.36e-81 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 264.61 E-value: 3.36e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 3 SLSFPRRTKIVATIGPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGK 82
Cdd:PLN02765 23 PSFFPALTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVIN 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 83 FACGSITLKPGEHFILTS-RDVECNQEISSISYPSLAQEVPEGSRILL--------DDGKVEMRVESVDrlKGDLSCRV- 152
Cdd:PLN02765 103 KTEKPISLKAGNTVTLTPdQSKEASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVK--GDDVVCTVk 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 153 ---VVGGVL----SSNKGVNFPnvylsvkALTDKDKKDL-MFGLLWDVDWIALSFVRNPQDILEIKELIASAG-KSIPVI 223
Cdd:PLN02765 181 nsaTLAGSLftlhVSQVRIDLP-------TLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 224 AKIEKHEAIEEMEAILSLCDGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITaTQMLDSMASNPRPTRAEVSDV 303
Cdd:PLN02765 254 AKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDV 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 304 ANAILDGTDAVMLSNETAVGHYPIEAVATMARI---AERIEREQinSAARSNNKQSIPN-----AISSAVSQIAEQLGAA 375
Cdd:PLN02765 333 ANAVLDGADAILLGAETLRGLYPVETISTVGRIcaeAEKVFNQD--LYFKKTVKYVGEPmshleSIASSAVRAAIKVKAS 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 376 AIITLTKTGSTARNVSRFRPKTPILAVTPHREV-------------AQQLQLVWGVKPML---LLDLPSTSQT----FQV 435
Cdd:PLN02765 411 VIIVFTSSGRAARLIAKYRPTMPVLSVVIPRLKtnqlkwsftgafqARQCLIVRGLFPMLadpRHSAESTSATnesvLKV 490
|
490
....*....|....*...
gi 917763701 436 AMNLAQENNLLADGDLVV 453
Cdd:PLN02765 491 ALDHGKAAGVIKSHDRVV 508
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
8-344 |
8.79e-45 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 165.96 E-value: 8.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 8 RRTKIVATI-GPASQNKETLRQMIKAGATTFRLNFSHGDHDYHRHSINLIRQLAFELNQPIGILQDLQGPKIRLGKFAC- 85
Cdd:PRK08187 133 RRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGAVAGp 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 86 -GSITLKPGEHFILT------SRDVECNQeiSSISYPSLAQEVPEGSRILLDDGKVEMRVESVDRlkGDLSCRVV----V 154
Cdd:PRK08187 213 lGKTRLYTGDRLALVaqgpprRIDEEHFQ--VTCTLPEILARLAVGARVWIDDGKLGARVERVGP--GGALLEVTharpK 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 155 GGVLSSNKGVNFPNVYLSVKALTDKDKKDLMFgLLWDVDWIALSFVRNPQDI----LEIKELIASAGKSIPVIAKIEKHE 230
Cdd:PRK08187 289 GLKLKPEKGLNFPDTALDLPALTEKDRADLDF-VARHADLVGYSFVQSPGDVealqAALAARRPDDWRKLGLVLKIETPR 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 231 AIEEMEAIL-----SLCDGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVAN 305
Cdd:PRK08187 368 AVANLPELIvqaagRQPFGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAM 447
|
330 340 350
....*....|....*....|....*....|....*....
gi 917763701 306 AilDGTDAVMLSNetavGHYPIEAVATMARIAERIEREQ 344
Cdd:PRK08187 448 A--ARAECVMLNK----GPYLVEAVTFLDDLLARMDGHQ 480
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
86-344 |
5.26e-42 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 160.12 E-value: 5.26e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 86 GSITLKPGEHFILTSRDVECNQEISSISYPSLAQEVPE-------GSRILLDDGKVEMRVESVDRlkGDLSCRVV---VG 155
Cdd:PRK14725 331 QKLRLKVGDRLVLTRDDAPGDPAQGDAPPARISCTLPEafraarvGERVWFDDGKIGAVVVKVEA--DEVELRITharPG 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 156 GV-LSSNKGVNFPNVYLSVKALTDKDKKDLMFGLLWdVDWIALSFVRNPQDILEIKELIASAG-KSIPVIAKIEKHEAIE 233
Cdd:PRK14725 409 GSkLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPEDVRLLLDALEKLGaDDLGVVLKIETRRAFE 487
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 234 EMEAIL-----SLCDGVMVARGDLGVELPAEDVPILQKRLINTANQLGIPIITATQMLDSMASNPRPTRAEVSDVANAIL 308
Cdd:PRK14725 488 NLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR 567
|
250 260 270
....*....|....*....|....*....|....*.
gi 917763701 309 dgTDAVMLSNetavGHYPIEAVATMARIAERIEREQ 344
Cdd:PRK14725 568 --AECVMLNK----GPHIVEAVRVLDDILRRMEEHQ 597
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
359-471 |
2.06e-40 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 142.62 E-value: 2.06e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 359 NAISSAVSQIAEQLGAAAIITLTKTGSTARNVSRFRPKTPILAVTPHREVAQQLQLVWGVKPMLLLDLPSTSQTFQVAMN 438
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAVK 80
|
90 100 110
....*....|....*....|....*....|...
gi 917763701 439 LAQENNLLADGDLVVMTAGTLQGVAGSTDLIKV 471
Cdd:pfam02887 81 VAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKV 113
|
|
| PpsA |
COG0574 |
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and ... |
470-578 |
3.21e-24 |
|
Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase is part of the Pathway/BioSystem: Gluconeogenesis
Pssm-ID: 440339 [Multi-domain] Cd Length: 455 Bit Score: 105.68 E-value: 3.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 470 KVEVVKSLLGKGTGIGQGVASGRARVAHNAREVGSFSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLG 549
Cdd:COG0574 346 KAKEEGEVLAKGLPASPGAASGKVVFIADEAELARFQEGVILVRDETDPDDVPGMKAAAGIVTERGGMTSHAAIVARELG 425
|
90 100
....*....|....*....|....*....
gi 917763701 550 IPVIVGVKDATKIIREGVIISLDAQRGLI 578
Cdd:COG0574 426 IPAVVGCGDATRVLKDGDEITVDGTTGEV 454
|
|
| PRK06464 |
PRK06464 |
phosphoenolpyruvate synthase; Validated |
478-582 |
1.05e-23 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235809 [Multi-domain] Cd Length: 795 Bit Score: 105.98 E-value: 1.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 478 LGKGTGIGQGVASGRARVAHNAREVGSFSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIVGVK 557
Cdd:PRK06464 356 LVEGRAIGPGIGSGKVRVILDISEMDKVQPGDVLVTDMTDPDWEPVMKRASAIVTNRGGRTCHAAIIARELGIPAVVGTG 435
|
90 100
....*....|....*....|....*...
gi 917763701 558 DATKIIREGVIISL---DAQRGLIYSGI 582
Cdd:PRK06464 436 NATEVLKDGQEVTVscaEGDTGYVYEGL 463
|
|
| PEP_synth |
TIGR01418 |
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member ... |
478-582 |
1.34e-23 |
|
phosphoenolpyruvate synthase; Also called pyruvate,water dikinase and PEP synthase. The member from Methanococcus jannaschii contains a large intein. This enzyme generates phosphoenolpyruvate (PEP) from pyruvate, hydrolyzing ATP to AMP and releasing inorganic phosphate in the process. The enzyme shows extensive homology to other enzymes that use PEP as substrate or product. This enzyme may provide PEP for gluconeogenesis, for PTS-type carbohydrate transport systems, or for other processes. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273612 [Multi-domain] Cd Length: 786 Bit Score: 105.59 E-value: 1.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 478 LGKGTGIGQGVASGRARVAHNAREVGSFSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIVGVK 557
Cdd:TIGR01418 355 LVTGRAAGPGIASGKVKVIFDLKEMDKFEEGDILVTDMTDPDWEPAMKRASAIVTNEGGMTCHAAIVARELGIPAVVGTG 434
|
90 100
....*....|....*....|....*...
gi 917763701 558 DATKIIREGVIISLDAQR---GLIYSGI 582
Cdd:TIGR01418 435 DATKTLKDGMEVTVDCAEgdtGYVYAGK 462
|
|
| PEP-utilizers |
pfam00391 |
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain ... |
505-576 |
2.58e-20 |
|
PEP-utilizing enzyme, mobile domain; This domain is a "swivelling" beta/beta/alpha domain which is thought to be mobile in all proteins known to contain it.
Pssm-ID: 459796 [Multi-domain] Cd Length: 73 Bit Score: 85.15 E-value: 2.58e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 917763701 505 FSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIVGVKDATKIIREGVIISLDAQRG 576
Cdd:pfam00391 2 LPEGVILVAPDTTPSDTAGLDKAAGIVTERGGMTSHAAIVARELGIPAVVGVGDATILLKEGDLVTVDGSTG 73
|
|
| PRK08296 |
PRK08296 |
hypothetical protein; Provisional |
480-578 |
3.20e-15 |
|
hypothetical protein; Provisional
Pssm-ID: 181362 Cd Length: 603 Bit Score: 78.93 E-value: 3.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 480 KGTGIGQGVASGRARVAHNAREVGSFSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIVGVKDA 559
Cdd:PRK08296 501 KGFAASPGVVEGPARVIRSADELSEVQEGEILVCPVTSPSWAPIFAKIKATVTDIGGVMSHAAIVCREYGLPAVVGTGNA 580
|
90
....*....|....*....
gi 917763701 560 TKIIREGVIISLDAQRGLI 578
Cdd:PRK08296 581 TKRIKTGQRLRVDGTKGVV 599
|
|
| PRK06241 |
PRK06241 |
phosphoenolpyruvate synthase; Validated |
481-578 |
6.30e-11 |
|
phosphoenolpyruvate synthase; Validated
Pssm-ID: 235751 [Multi-domain] Cd Length: 871 Bit Score: 65.30 E-value: 6.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 481 GTGIGQGVASGRARVAHNAREVGSfSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIVGVKDAT 560
Cdd:PRK06241 770 GLPVSSGVVEGRARVILNPEDADL-EKGDILVTAFTDPGWTPLFVSIKGLVTEVGGLMTHGAVIAREYGIPAVVGVENAT 848
|
90
....*....|....*...
gi 917763701 561 KIIREGVIISLDAQRGLI 578
Cdd:PRK06241 849 KLIKDGQRIRVDGTEGYV 866
|
|
| PRK05878 |
PRK05878 |
pyruvate phosphate dikinase; Provisional |
476-582 |
1.07e-09 |
|
pyruvate phosphate dikinase; Provisional
Pssm-ID: 235635 [Multi-domain] Cd Length: 530 Bit Score: 60.91 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 476 SLLGKGTGIGQGVASGRARV-AHNAREVGSFSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGIPVIV 554
Cdd:PRK05878 348 PLLAKGLPACPGVVSGTAYTdVDEALDAADRGEPVILVRDHTRPDDVHGMLAAQGIVTEVGGATSHAAVVSRELGRVAVV 427
|
90 100
....*....|....*....|....*...
gi 917763701 555 GVKDATKIIREGVIISLDAQRGLIYSGI 582
Cdd:PRK05878 428 GCGAGVAAALAGKEITVDGYEGEVRQGV 455
|
|
| PRK05865 |
PRK05865 |
sugar epimerase family protein; |
474-578 |
1.52e-07 |
|
sugar epimerase family protein;
Pssm-ID: 235630 [Multi-domain] Cd Length: 854 Bit Score: 54.66 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 474 VKSLLGKGTGIGQGVASGRAR---VAHNAREVGSFSSGEILVVPTTSAEYVDMMRKAGGIITEDNAMNNHAATIGLKLGI 550
Cdd:PRK05865 727 AAALAAGDTLRGVGVCGGRVRgrvRIVRPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGF 806
|
90 100
....*....|....*....|....*...
gi 917763701 551 PVIVGVKDATKIIREGVIISLDAQRGLI 578
Cdd:PRK05865 807 PCVVDAQGATRFLPPGALVEVDGATGEI 834
|
|
| PtsA |
COG1080 |
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate ... |
529-579 |
9.49e-04 |
|
Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism];
Pssm-ID: 440698 [Multi-domain] Cd Length: 571 Bit Score: 41.99 E-value: 9.49e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 917763701 529 GIITEDNAMNNHAATIGLKLGIPVIVGVKDATKIIREGVIISLDAQRGLIY 579
Cdd:COG1080 177 GFVTDLGGRTSHTAILARSLGIPAVVGLGDALLLVKDGDLVIVDGDAGVVI 227
|
|
| HpcH |
COG3836 |
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism]; |
209-278 |
6.74e-03 |
|
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];
Pssm-ID: 443047 [Multi-domain] Cd Length: 237 Bit Score: 38.56 E-value: 6.74e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 917763701 209 IKELIASAGKSIPVIAKIEKHEAIEEMEAILSL--CDGVMVARGDLGVEL---PAEDVPILQ---KRLINTANQLGIP 278
Cdd:COG3836 131 VADYLARANDETLVIVQIETAEAVENLDEIAAVpgVDGVFIGPADLSASLghpGQPDHPEVQaaiERVIAAARAAGKP 208
|
|
| CitE |
COG2301 |
Citrate lyase beta subunit [Carbohydrate transport and metabolism]; |
192-280 |
8.75e-03 |
|
Citrate lyase beta subunit [Carbohydrate transport and metabolism];
Pssm-ID: 441876 Cd Length: 288 Bit Score: 38.59 E-value: 8.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 917763701 192 VDWIALSFVRNPQDILEIKELIASAGK---SIPVIAKIEKHEAIEEMEAILSLCDGVMVAR-------GDLGVELPAEDV 261
Cdd:COG2301 89 LDGIVLPKVESAEDVRALAALLTELEAeggSIPLMALIETARGLLNAAEIAAASPRVEALVfgaedlaADLGARRTRDGD 168
|
90 100
....*....|....*....|.
gi 917763701 262 PILQ--KRLINTANQLGIPII 280
Cdd:COG2301 169 ELLYarSRIVLAARAAGLAAI 189
|
|
| |
