|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
23-404 |
8.86e-137 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 396.98 E-value: 8.86e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 23 LMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVL 102
Cdd:cd17394 1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 103 FYPAAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILAATSEAGS- 181
Cdd:cd17394 81 FIPAASLRTYGLFLIALFVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIPSTATa 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 182 ----------------AKSVQTPYLIIAGALVIVALLFLKMKLPNI--SEHVEKDQASPPFSLFAHKHLYLGVLAIFLYV 243
Cdd:cd17394 161 laamsaaelqayktaeLASVQLPYLGIALVLLLLAVLILLSKLPEIeaAEAEALGSKGTLLRLLKNPHLRLGVLAIFFYV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 244 GAEVSIGSYLVNLFMQLGIdNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGSLA 323
Cdd:cd17394 241 GAEVAIWSFLINYLMEYIA-GLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLLLLLGAIFTGGMVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 324 MWSILAVGFFNSIMFPTIFTLAIRGLGEYTGRGSGYLCQGIVGGAILPLLQG-FAADAMGLQMSFLIPAISYLYIAWYAV 402
Cdd:cd17394 320 LYALVLVGFFNSIMFPTIFSLALKGLGKHTKTGSGLLVMAIVGGAVVPLIQGaVADDAAGLRIAFLVPLLCFAYILFYGL 399
|
..
gi 918231292 403 KG 404
Cdd:cd17394 400 RG 401
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-407 |
7.17e-95 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 289.45 E-value: 7.17e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 18 NARFALMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIA 97
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 98 SGCVLFypaAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPEsTAASRLNLAQAINSVGHTAGPMFGALLILaats 177
Cdd:COG0738 85 LGLLLF---ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLIL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 178 eAGSAKSVQTPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASP--PFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVN 255
Cdd:COG0738 157 -LGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAasLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 256 LFMQlgIDNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGS-LAMWSILAVGFFN 334
Cdd:COG0738 236 YLKD--VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPwLALIGLALVGLGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 918231292 335 SIMFPTIFTLAIRGLGEYTG-RGSGYLCQGIVGGAILPLLQGFAADAMGLQMSFLIPAISYLYIAWYAVKGSKI 407
Cdd:COG0738 314 SLMFPTIFSLALDGLGKRTAaAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| gluP |
TIGR01272 |
glucose/galactose transporter; This model describes the glucose/galactose transporter in ... |
103-400 |
4.67e-87 |
|
glucose/galactose transporter; This model describes the glucose/galactose transporter in bacteria. This belongs to the larger facilitator superfamily. Disruption of the loci leads to the total loss of glucose or galactose uptake in E.coli. Putative transporters in other bacterial species were isolated by functional complementation, which restored it functional activity. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273531 [Multi-domain] Cd Length: 310 Bit Score: 266.76 E-value: 4.67e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 103 FYPAAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILAATSEAGS- 181
Cdd:TIGR01272 1 FGPAASQRYYVLFLGALFVLASGLTILQVAANPYVSILGPIETAASRLALTQAFNKLGTTVAPLFGGSLILSGAGDLSMq 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 182 -------AKSVQTPYLIIAGALVIVALLFLKMKLPNISEH----VEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIG 250
Cdd:TIGR01272 81 vatanaeAAKVHTPYLLLAGALAVLAIIFAFLPLPELQEAdvarVSSGDTTQKTSAFQFTHLVLGALGIFVYVGAEVSAG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 251 SYLVNLFMQLGIDNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGSLAMWSILAV 330
Cdd:TIGR01272 161 SFLVNFLSDPHALGLPEDQAAHFTAYTWGGAMVGRFIGSAVMPMISQGRYLAFNAFLAVLLSIGAALTHGYVAMWFVLAL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 331 GFFNSIMFPTIFTLAIRGLGEYTGRGSGYLCQGIVGGAILPLLQGFAADAMGLQMSFLIPAISYLYIAWY 400
Cdd:TIGR01272 241 GLFNSIMFPTIFSLALNALGRHTSQGSGILCLAIVGGAIVPLLQGSLADCLGIQLAFALPVPCYLYILFY 310
|
|
| PRK10133 |
PRK10133 |
L-fucose:H+ symporter permease; |
25-401 |
1.31e-72 |
|
L-fucose:H+ symporter permease;
Pssm-ID: 182260 [Multi-domain] Cd Length: 438 Bit Score: 234.02 E-value: 1.31e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 25 VMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFY 104
Cdd:PRK10133 30 LLCSLFFLWAVANNLNDILLPQFQQAFTLTNFQAGLIQSAFYFGYFIIPIPAGILMKKLSYKAGIITGLFLYALGAALFW 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 105 PAAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILA---------- 174
Cdd:PRK10133 110 PAAEIMNYTLFLVGLFIIAAGLGCLETAANPFVTVLGPESSGHFRLNLAQTFNSFGAIIAVVFGQSLILSnvphqsqdvl 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 175 --ATSEAGSAK------SVQTPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFS-----LFAHKHLYLGVLAIFL 241
Cdd:PRK10133 190 dkMTPEQLSAYkhslvlSVQTPYMIIVAIVLLVALLIMLTKFPALQSDNHSDAKQGSFSaslsrLARIRHWRWAVLAQFC 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 242 YVGAEVSIGSYLVnlfmQLGIDNMNEVTAGKMVSYYWGAAM---VGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNM 318
Cdd:PRK10133 270 YVGAQTACWSYLI----RYAVEEIPGMTAGFAANYLTGTMVcffIGRFTGTWLISRFAPHKVLAAYALIAMALCLISAFA 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 319 EGSLAMWSILAVGFFNSIMFPTIFTLAIRGLGEYTGRGSGYLCQGIVGGAILPLLQGFAADAMG-LQMSFLIPAISYLYI 397
Cdd:PRK10133 346 GGHVGLIALTLCSAFMSIQYPTIFSLGIKNLGQDTKYGSSFIVMTIIGGGIVTPVMGFVSDAAGnIPTAELIPALCFAVI 425
|
....
gi 918231292 398 AWYA 401
Cdd:PRK10133 426 FIFA 429
|
|
| fucP |
TIGR00885 |
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. ... |
25-401 |
3.73e-66 |
|
L-fucose:H+ symporter permease; This family describes the L-fucose permease in bacteria. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysaccharides. L-fucose is used in bacteria through an inducible pathway mediated by atleast four enzymes: a permease, isomerase, kinase and an aldolase which are encoded by fucP, fucI, fucK, fucA respectively. The fuc genes belong to a regulon comprising of four linked operons: fucO, fucA, fucPIK and fucR. The positive regulator is encoded by fucR, whose protein responds to fuculose-1-phosphate, which acts as an effector. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211614 Cd Length: 408 Bit Score: 216.26 E-value: 3.73e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 25 VMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFY 104
Cdd:TIGR00885 7 LITSLFALWGFANDITNPMVPQFQQAFTLTAFQAALVQSAFYGGYFIMAIPAAIFMKKLSYKAGILLGLFLYALGAFLFW 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 105 PAAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILA---------- 174
Cdd:TIGR00885 87 PAAEIMNYTLFLVGLFILTAGLGFLETAANPYILVMGPESTATRRLNLAQSFNPFGSIIGMVVAQQLILSnlphqsqdvl 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 175 ---ATSEAGSAK-----SVQTPYLIIAGALVIVALL--FLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVG 244
Cdd:TIGR00885 167 dklSPEELSAIKhsdlaSVQTPYMIIGAVVLAVALLimLTKMPALNHSDAKQISFSASLSRLARIRHYREGVIAQFFYVG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 245 AEVSIGSYLVnlfmQLGIDNMNEVTAGKMVSYYWGAAM---VGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGS 321
Cdd:TIGR00885 247 VQIMCWTFII----QYAVRLIPGMTAGFAANYNIGAMViffISRFIGTWLISYLAAHKVLMAYAIIGMALCLGSIFAGGH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 322 LAMWSILAVGFFNSIMFPTIFTLAIRGLGEYTGRGSGYLCQGIVGGAILPLLQGFAAD------AMGLQMSFLIPAISYL 395
Cdd:TIGR00885 323 VGLYCLTLCSAFMSLMFPTIYGIALKGLGQDTKYGAAGLVMAIIGGGIVPPLQGFIIDmkeiaaAPAVNTSFILPLLCFA 402
|
....*.
gi 918231292 396 YIAWYA 401
Cdd:TIGR00885 403 VIFIYG 408
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
28-398 |
5.29e-44 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 157.10 E-value: 5.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 28 SLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFYPAA 107
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 108 EIsmyPLFLFALFVLASGVTMLQVSANPYVAVLGPEStAASRLNLAQAINSVGHTAGPMFGALLILAATseagsakSVQT 187
Cdd:cd17333 83 SI---YLFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSEL-------SWSW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 188 PYLIIAG---ALVIVALLFLKMKLPNISEHVEKDQASPP--FSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFMQLgi 262
Cdd:cd17333 152 AYLIIGLiylLLAILILLTLFPELPSARNPQQSVGAFSAsaSRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEK-- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 263 DNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLA-ISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTI 341
Cdd:cd17333 230 KHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGAlLGLLILLLAPTLVVGLVATALLGLFMAALFPTI 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 918231292 342 FTLAIRGLGEYTGRGSGY-LCQGIVGGAILPLLQGFAADAMGLQMSFLIPAISYLYIA 398
Cdd:cd17333 310 LSLGISNLPYAKGKGTSVlLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIF 367
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
42-392 |
1.91e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 88.77 E-value: 1.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 42 ILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFypaAEISMYPLFLFALFV 121
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLL---GFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 122 LASGVTMLQVSANPYVAvlgpeSTAASRLNLAQAINSVGHTAGPMFGALLILAATSEAGSAKSvqTPYLIIAGALVIVAL 201
Cdd:cd17478 94 AGIGSAAFHPEGARLAS-----QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGL--LILLIIPGLAVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 202 LFLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFMQLGIDNmneVTAGKMVSYYWGAA 281
Cdd:cd17478 167 LRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSL---VFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 282 MVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFTLAIRGLGEYTGRGSG-YL 360
Cdd:cd17478 244 AIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGlMM 323
|
330 340 350
....*....|....*....|....*....|..
gi 918231292 361 CQGIVGGAILPLLQGFAADAMGLQMSFLIPAI 392
Cdd:cd17478 324 GLSFGLGGIGAPVLGALADAFGLESVLLILAL 355
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-347 |
2.42e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 79.63 E-value: 2.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 13 SPAAFNARFALMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVG 92
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 93 LLTIASGCVLFYPAAEismYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLI 172
Cdd:COG2814 82 LLLFALGSLLCALAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 173 LAAtseagsakSVQTPYLIIAgALVIVALLFLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSY 252
Cdd:COG2814 159 DLF--------GWRWVFLVNA-VLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 253 LVNLFMQlgIDNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVL-AISMIVIAVNMEGSLAMWSILAVG 331
Cdd:COG2814 230 LPLYLQE--VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLlALGLLLLALAGSLWLLLLALFLLG 307
|
330
....*....|....*.
gi 918231292 332 FFNSIMFPTIFTLAIR 347
Cdd:COG2814 308 FGFGLLFPLLQALVAE 323
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-382 |
3.29e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 79.54 E-value: 3.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 21 FALMVMTSLFFIWGfitalndILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGC 100
Cdd:COG2223 12 LAFFLAFGVWYLWS-------VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 101 VLFYPAaeiSMYPLFLFALFVLASGVTMLQVSANPYVAVLGPestaASRLNLAQAINSVGHTAGPMFGALLILAATSEAG 180
Cdd:COG2223 85 LLLALA---VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFP----PDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 181 saksVQTPYLIIAGALVIVALLFLKM--KLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFM 258
Cdd:COG2223 158 ----WRNAFLILGILLLVVAVLAWLFlrDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 259 QLGidNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGS--LAMWSILAVGFFNSI 336
Cdd:COG2223 234 DQF--GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSlwLFLVLFLLLGLALGG 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 918231292 337 MFPTIFTLAIRGLG-EYTGRGSGYL-CQGIVGGAILPLLQGFAADAMG 382
Cdd:COG2223 312 GNGAVFALVPDIFPtKNAGAVYGLVgAAGGLGGFLGPLLFGALLDATG 359
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-395 |
2.98e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.45 E-value: 2.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 19 ARFALMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIAS 98
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 99 GCVLFypaAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPestaASRLNLAQAINSVGHTAGPMFGALLILAATSE 178
Cdd:COG2271 88 ATLLF---GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFP----PKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 179 AGsaksVQTPYLIIAGALVIVALLflkmklpnisehvekdqasppfslfahkHLYLGVLAIFLYVGAEVSIGSYLVNLFM 258
Cdd:COG2271 161 FG----WRAAFLILGLPGLLLALL----------------------------RFWLLALAYFLVYFALYGFLTWLPTYLV 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 259 QLGidNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKA---TTLLAINAVLAISMIVIAVNMEGSLAMWSILAVGFFNS 335
Cdd:COG2271 209 EVR--GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 918231292 336 IMFPTIFTLAIRGLG-EYTGRGSGYLCQ-GIVGGAILPLLQGFAADAMGLQMSFLIPAISYL 395
Cdd:COG2271 287 GAFGLLWALAAELFPkKARGTASGLVNTfGFLGGALGPLLVGYLLDATGYQAAFLLLAALAL 348
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
43-382 |
1.99e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 71.06 E-value: 1.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 43 LLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFYPAAeiSMYPLFLFALFVL 122
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 123 AsGVTMLQVSANPYVAVLGPEstaasRLNLAQAINSVGHTAGPMFGALLILAATSEAGsaksVQTPYLIIAGALVIVALL 202
Cdd:COG2807 118 A-GIAVGNVLLPGLIKRWFPD-----RVGLMTGLYTAAMGLGAALAAGLTVPLAAALG----WRGALAVWALLALLALLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 203 FLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFMQLGIDnmnEVTAGKMVSYYWGAAM 282
Cdd:COG2807 188 WLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLS---AATAGLLLSLFQLAGI 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 283 VGRFIGAAILNFIKA-TTLLAINAVLAISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFTLAIR--GLGEYTGRGSGy 359
Cdd:COG2807 265 PGSLLVPLLADRLGDrRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLraRTPAEAAALSG- 343
|
330 340
....*....|....*....|....*
gi 918231292 360 LCQGI--VGGAILPLLQGFAADAMG 382
Cdd:COG2807 344 MAQSVgyLLAALGPLLVGALHDATG 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
30-392 |
2.32e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.68 E-value: 2.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 30 FFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFypaAEI 109
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF---AFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 110 SMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLIlaatseagSAKSVQTPY 189
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLA--------DALGYRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 190 LIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFMQL---GIDNMN 266
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLyaaELGGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 267 EVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAI-NAVLAISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFTLA 345
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIgLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 918231292 346 I-----RGLGEYTGRGSGYLCQGIVGGailPLLQGFAADAMGLQMSFLIPAI 392
Cdd:cd17325 314 AdivppEGRGTAMGLFNTAFSLGMVLG---PLLGGFLYDAFGFATPFLAAAA 362
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-392 |
7.86e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.16 E-value: 7.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 25 VMTSLFFIWGFITALNDILLPYLKNaFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFY 104
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 105 PAAEIsmyPLFLFALFVLASGVTMLQVSANPYVAVLGPEstaaSRLNLAQAINSVGHTAGPMFGALLILAATSEAGsaks 184
Cdd:cd17489 80 LATSV---ALLLVLRLIHGIGWGAFTTAAATLVADIIPP----SRRGEGIGYYGLATTLAMALGPALGLFLYQHLG---- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 185 VQTPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFMQLGIDN 264
Cdd:cd17489 149 FAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 265 mnevtAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMeGSLAMWSILAV--GFFNSIMFPTIF 342
Cdd:cd17489 229 -----AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA-GSPWMLLLAAVlyGLGFGLLFPALQ 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 918231292 343 TLAIRGLGEyTGRG---SGYLCQGIVGGAILPLLQGFAADAMGLQMSFLIPAI 392
Cdd:cd17489 303 ALAVDLVPP-HRRGaanGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAV 354
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
29-402 |
3.54e-12 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 67.28 E-value: 3.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 29 LFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLtIASGCVLFYPAAE 108
Cdd:cd17393 7 FFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGAL-LLLLALLLLGLAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 109 IsmYPLFLFALFVLASGVTMLQVSANpyvaVLGPESTAASR---LNLAQAINSVGHTAGPMFGALLILAATSEAGSAksv 185
Cdd:cd17393 86 S--VPALALALFLFGAANGALDVAMN----AQGVAVERAYGrpiMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHL--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 186 qTPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGaEVSIGSYLVnLFMQlGIDNM 265
Cdd:cd17393 157 -LAAAVLLLLAALVAIRALLPGTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALA-EGAAADWSA-LYLR-DVLGA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 266 NEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGS-LAMWSILAVGFFNSIMFPTIFTL 344
Cdd:cd17393 233 SAALAALGYAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVwVALAGFALMGLGLSVVVPLAFSA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 918231292 345 AIRGLGEYTGRG-SGYLCQGIVGGAILPLLQGFAADAMGLQMSFLIPAISYLYIAWYAV 402
Cdd:cd17393 313 AGALPGLAAGIAvARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLAR 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-351 |
6.19e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 66.29 E-value: 6.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 25 VMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFY 104
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 105 PAAEIsmyPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLIlaatseagSAKS 184
Cdd:pfam07690 81 FASSL---WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------SLFG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 185 VQTPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFMQLGID- 263
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEv 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 264 -NMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAIN----AVLAISMIVIAVNMEGSLAMWSILAVGFFNSIMF 338
Cdd:pfam07690 230 lGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAllllILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVF 309
|
330
....*....|...
gi 918231292 339 PTIFTLAIRGLGE 351
Cdd:pfam07690 310 PALNALVSDLAPK 322
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
26-392 |
4.34e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 63.98 E-value: 4.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 26 MTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFYP 105
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 106 AAeisMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILAATSeagsakSV 185
Cdd:cd06174 81 AP---SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF------GW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 186 QTPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFSLFAH-------KHLYLGVLAIFLYVGAEVSIGSYLVNLFM 258
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLlkrvlknPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 259 QLGidNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAIN--AVLAISMIVIAVNMEGSLAMWSILAVGFFNSI 336
Cdd:cd06174 232 DLG--GLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIglLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 918231292 337 MFPTIFTLAIR-GLGEYTGRGSG-YLCQGIVGGAILPLLQGFAADAM-GLQMSFLIPAI 392
Cdd:cd06174 310 LLPLSFALIAElFPPEIRGTAFGlLNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAV 368
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
63-345 |
4.37e-11 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 64.18 E-value: 4.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 63 FCFFGAYFIVSPFAGRFL-EKIGYKKGIVVG-LLTIASGCVLFYPAaeiSMYpLFLFALFVLA--SGVTMlqvSANPYVA 138
Cdd:PRK03699 48 FTFLNAGILISIFLNAWLmEIIPLKRQLIFGfALMILAVAGLMFSH---SLA-LFSIAMFVLGvvSGITM---SIGTFLI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 139 V-LGPESTAASRLNLAQAINSVGHTAGPMFGALLILAATSEAGSaksvqtpYLIIAGALVIVALLFLKMKLPNISEHVEK 217
Cdd:PRK03699 121 ThVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSIEWYWV-------YACIGLVYVAIFILTLFSEFPALGKHAPK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 218 DQASPPFSLFAHKhLYLGVLAIFLYVGAEVSIGSYlVNLFMQLGIDnMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKA 297
Cdd:PRK03699 194 ADKPVAKEKWGIG-VLFLAIAALLYILAQLTFISW-VPEYAQKKFG-MSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDL 270
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 918231292 298 TTLLAINAVLA-ISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFTLA 345
Cdd:PRK03699 271 QRILTVLAGLAlVLMYLFVNTDDPSHLLYAILGLGFFSSAIYTTIITLG 319
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
43-389 |
5.68e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.17 E-value: 5.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 43 LLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLfypAAEISMYPLFLFALFVL 122
Cdd:cd17324 21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL---AALAPSFALLLLARALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 123 ASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLilaatseaGSAKSVQTPYLIIAGALVIVALL 202
Cdd:cd17324 98 GLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL--------GQLLGWRAAFLAIAVLALLAALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 203 FLKmKLPNISEH--VEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVnLFMQLGIDNMNEVTAGKMVSYYwGA 280
Cdd:cd17324 170 LWR-LLPSLPPKkpGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLA-PFLTDVPGFSSSAIIGLLLLFG-VA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 281 AMVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGSLAMWSILAV-GFFNSIMFPTIFTLAIRGLGEYTGRGSG- 358
Cdd:cd17324 247 GVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLwGLGFFAAHSALQTRVLRLAPEARGLASSl 326
|
330 340 350
....*....|....*....|....*....|.
gi 918231292 359 YLCQGIVGGAILPLLQGFAADAMGLQMSFLI 389
Cdd:cd17324 327 YLAAYNLGGALGAALGGLVLDHGGWAGVGWV 357
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-207 |
9.43e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.82 E-value: 9.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 22 ALMVMTSLFFIWGFITALNDILLP-YLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGC 100
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 101 VLFYPAAEismYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILAAtseag 180
Cdd:cd17325 280 LLLPLATS---FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF----- 351
|
170 180
....*....|....*....|....*..
gi 918231292 181 sakSVQTPYLIIAGALVIVALLFLKMK 207
Cdd:cd17325 352 ---GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
43-399 |
3.05e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.19 E-value: 3.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 43 LLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLfypAAEISMYPLFLFALFVL 122
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL---CGLSDSFALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 123 ASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLilaatseagSAKSVQTPYLIIAgALVIVALL 202
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL---------AAISWRYPFFLLA-ALIPVAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 203 FLKMKLPNISEHVEKDQASPPFSLFAHKHlyLGVLAIFLYVGAEVSIGSYLVNLFMQLGIDNMNEVTAGK--MVSYYWGA 280
Cdd:cd17474 168 AILFLLPEPKEKAKSSSATKLRDLKKALR--GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIigLLFAGWSV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 281 AM-VGRFIGAAILN--FIKATTLLAINAVLAISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFTLAIRGLGEYTgRG- 356
Cdd:cd17474 246 LLaLGSLFVGRLLKkrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEE-RGt 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 918231292 357 --SGYLCQGIVGGAILPLLQGFAADAMGLQMSFLIPAISYLYIAW 399
Cdd:cd17474 325 asSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
71-392 |
8.47e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 8.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 71 IVSPFAGRFLEKIGYKKGIVVGL-LTIASGCVLFYpaaeISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASR 149
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLlLYGIGGVAGLF----LDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKM 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 150 LNLAQAINSVGHTAGPMFGALLilaatseagSAKSVQTPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFSLFAH 229
Cdd:cd17473 126 LGLQSAAMSLGGVVFLLLGGAL---------AEIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPW 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 230 KHLYLGVLAIFLyvgaeVSIGSYLVNLFMQLGIDNMNEVTAgKMVSYYWGAAMVGRFIGAAILNFIK-----ATTLLAIN 304
Cdd:cd17473 197 KRVLPIYFLAFL-----AMLLFYVIPIQLPFLLQERGGGSA-ALIGLALAIASLAGAIGALLFGRLKrrlgkRRLLAIGF 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 305 AVLAISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFTLAIRGLG-EYTGRGSGYLCQGIVGGAIL--PLLQGFAADAM 381
Cdd:cd17473 271 ALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGIVTSAFFLGQFLspLVLGPLVNLTG 350
|
330
....*....|.
gi 918231292 382 GLQMSFLIPAI 392
Cdd:cd17473 351 GLSGAFLILGV 361
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
56-398 |
2.42e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 2.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 56 FQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFYPAAEIsmyPLFLFALFVLASGVTMLQVSANP 135
Cdd:cd17477 31 ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP---WVWFLLRFVMGIGLAGLFVVSES 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 136 YVAVLGPESTAASRLNLAQAINSVGHTAGPmfgalLILAATSEAGsaksvQTPYLIIAG--ALVIVALLFLKMKLPNISE 213
Cdd:cd17477 108 WLNALATNENRGRVLGLYSTVLGLGFALGP-----LLLALVGTAG-----ALPFLIAAVllLLALVPLLLTRRAAPEIEE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 214 HvekdQASPPFSLFahKHLYLGVLAIFLYVGAEVSIGSYLVNLFMQLGIDnmNEVTAGKMVSYYWGAAMVGRFIGAAILN 293
Cdd:cd17477 178 A----ESISLRRLL--RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLS--VAQAALLLAAFVLGGLLLQWPLGWLADR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 294 FIKATTLLAINAVLAISMIVIAVNMEGSLAMWsilAVGFFNSIMFPTIFTLAIRGLGEYTGRG------SGYLCQGIVGG 367
Cdd:cd17477 250 FDRRRVLLGCALLGALAALLLPLVPGLPLALL---VLLFLWGGAAGPLYTLALALAGDRLPGDelvaanAALLLLYGLGS 326
|
330 340 350
....*....|....*....|....*....|.
gi 918231292 368 AILPLLQGFAADAMGLQMSFLIPAISYLYIA 398
Cdd:cd17477 327 VIGPLLAGALMDAFGPHGLFLFLAAVALLFL 357
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
18-134 |
3.61e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 48.73 E-value: 3.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 18 NARFALMVMTSLFFIWGFITALndILLP-YLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTI 96
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAM--FLLPlYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLL 254
|
90 100 110
....*....|....*....|....*....|....*...
gi 918231292 97 ASGCVLFYPAAEISMYPLFLFALFVLASGVTMLQVSAN 134
Cdd:cd17503 255 ALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLN 292
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
15-204 |
5.77e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 5.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 15 AAFNARFALMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLL 94
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 95 TIASGCVLFYPAAEISMYpLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLN---LAQAINSVGHTAGPMFGALL 171
Cdd:COG2211 303 LAALGLLLLFFLGPGNLW-LLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRregLYFGIFTFAIKLGQALAGAL 381
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 918231292 172 ILAATSEAG-SAKSVQTP---------YLIIAGALVIVALLFL 204
Cdd:COG2211 382 AGLLLALFGyVAGAAQSPsaltgirllFFLLPAVLLLLAALLL 424
|
|
| MFS_MFSD4 |
cd17395 |
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ... |
167-375 |
1.11e-05 |
|
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340953 [Multi-domain] Cd Length: 367 Bit Score: 47.13 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 167 FGALLILAATSEAGSAKSVQTPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFSLFAHkhLYLGVLAIFLYVGAE 246
Cdd:cd17395 131 FGAFLAPLIADPFLSYAYWIMALINLPVPMAVLMLLSKERLLTCCSQRRRKNLRRAPYSFFAI--HITGALFLFMYVGLE 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 247 VSIGSYLVNlFMQLGIdNMNEVTAGKMVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLAI-SMIVIAVNMEGSLAMW 325
Cdd:cd17395 209 GAYGAFVYS-YAVEKP-GVGHKVAAYLPSLFWGTFTLGRLLSIPISSRMKPATMVVLNVVGVVvTSLVLLLFSKSVVFLW 286
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 918231292 326 SILAV-GFFNSIMFPTIFTLaIRGLGEYTGRGSGYLCQGI-VGGAILPLLQG 375
Cdd:cd17395 287 IGTASlGLFLASTFPSMLSY-TEDSLQYTGCSTTVLVTGAgLGEMVLPMLVG 337
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
19-382 |
5.79e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.95 E-value: 5.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 19 ARFALMVMTSLFFIWGFITALNDILLPYLKN-AFSLTYFQAGL-VQFCFFGayfIVSPFAGRFLEKIGYKKGIVVGLLTI 96
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEfGWSRAVISLAFtVGLLAFG---LAQPFVGRLLDRFGPRRVMLLGLLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 97 ASGCVLFYPAAEISMyplFLFALFVLasGVTMLQVSANPYVAVLGPESTAASRlNLAQAINSVGHTAGPMFGALLILAAT 176
Cdd:cd17355 79 AAGLVLLALATSLWQ---LYLLWGLL--GGGGAGTLAAVAFATVAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 177 SEAGSAKSVQTPYLIIAGALVIVALLFLKM----KLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIgsy 252
Cdd:cd17355 153 EAFGWRTALLVLALLALLVLVPVLLLLRRRpadlALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGL--- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 253 LVNLFMQLGIDNMNEVTAGKMVSYYWGAAMVGR-FIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGSLAMW-SILAV 330
Cdd:cd17355 230 IVHLVPYLADRGISPAAAAVALALIGLFNIVGRlLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLlFAALF 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 918231292 331 GFFNSIMFPTIFTLAIR--GLGEYTGRGSGYLCQGIVGGAILPLLQGFAADAMG 382
Cdd:cd17355 310 GLGWGATVPLTAALAARyfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
4-160 |
1.29e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 4 STSGTERQPSPAAFNARFALMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKI 83
Cdd:COG2814 191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 918231292 84 GYKKGIVVGLLTIASGCVLFYPAaeiSMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVG 160
Cdd:COG2814 271 GRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
71-343 |
1.87e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 43.45 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 71 IVSPFAGRFLEKIGYKKG-----IVVGLLTIASGCVLFYPAAEISMYPLFLFAL---FVLASGVTMLQVSANPYVAVLGP 142
Cdd:pfam13347 48 FTDPIVGHIIDRTRTRWGrrrpwLLLSAIILAVSFILLFTPPELGRAPLFIWLLatyILLRIAYTFFEIPYWSLGPELTR 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 143 ESTAASRLNLAQAINSVGHTAGPMFGALLILAATSEAGSAKSVQTPYLIIAGALVIVALLF----LKMKLPNISEHVEKD 218
Cdd:pfam13347 128 DYDERTSLTSYRSFFSVGGGLLAAALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIItaagTKERVSMRSKEDTGQ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 219 QASPPF-----SLFAHKhLYLGVLAIFLYVGAEVSIGSYLVNLFMQLGIDNmnevtaGKMVSYYWGAAMVGRFIGAAILN 293
Cdd:pfam13347 208 KEAGSLldmlkEVFRNR-AFLILLASFLLAALAMGVLNGLLLYYFRYVLGN------GFAASAFPLVFTIGALLGIPLWP 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 918231292 294 FI------KATTLLAINAVLAISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFT 343
Cdd:pfam13347 281 PLakrigkKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPW 336
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
44-397 |
2.09e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.95 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 44 LPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLfypAAEISMYPLFLFALFVLA 123
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL---CALASSIEQLLIARFLQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 124 SGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILaatseAGSAKSVQTPYLIIAGALVIVALLF 203
Cdd:cd17320 99 LGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLL-----FFGWRAIFVFLALLGLLLLLLVLLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 204 LKMKLPNISEHV-EKDQASPPFSLFAHKHLYLGVLAIFLYVGAE---VSIGSYLvnLFMQLGIDNMNEVTAGKMVSyywG 279
Cdd:cd17320 174 LPETLPEEKRKPlLSSLLRAYKRVLKNRRFLGYALALGLSFAGLfayLAAAPFI--YIEQLGLSPAQFGLLFALNA---I 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 280 AAMVGRFIGAAILNFIKATTLL----AINAVLAISMIVIAVNMEGSLA--MWSILAVGFFNSIMFPTIFTLAIRGLGEYT 353
Cdd:cd17320 249 ALILGSLLNGRLVRRFGPRRLLrlglLLLLAAALVLLLAALLGGLSLWplVAPLFLIFFGFGLIFPNATSLALEPFPHVA 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 918231292 354 GRGSG-----YLCQGIVGGAILPLLQGFAADAMGLQMSFLIPAISYLYI 397
Cdd:cd17320 329 GTASAllgflQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
22-207 |
2.35e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.95 E-value: 2.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 22 ALMVMTSLFFiwGFITALNDILLPYLKN-----AFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTI 96
Cdd:cd17504 180 LLANITALLA--GFGMFMVFQLLPQLLQlptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVIS 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 97 ASGCVLFypAAEISMYPLFLFALFVLASGVTMLQVS-ANPYVAVLGPESTAASrLNLAQAINSVGHTAGPMFGAlLILAA 175
Cdd:cd17504 258 AVGLLLL--ALLHSSLWALVVALLLIGIGLGLAFASlPNIVVESVPPDRTGIA-TGMNTVLRTIGSAIGPAIAG-AILTT 333
|
170 180 190
....*....|....*....|....*....|....*...
gi 918231292 176 TSEAGSAKSVQTP------YLIIAGALVIVALLFLKMK 207
Cdd:cd17504 334 YTVSITSGGVPTEgayvlaFLIGAALALAALLLSLLIP 371
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
27-392 |
1.22e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 27 TSLFFIWGFITAlndillpYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFYPA 106
Cdd:cd17329 13 LGFFMVWPFMAI-------YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 107 AEIsmyPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILAatseagsakSVQ 186
Cdd:cd17329 86 HSP---WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY---------SFR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 187 TPYLIIAGALVIVALLFLKMKLPNISEHVEKDQASPPFSL---FAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFMQLGID 263
Cdd:cd17329 154 LLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYkivLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 264 NMnevtagKMVSYYWGAAM---------VGRFIGaaILNFIKATTLLAINAVLAISMIVIAVNMEGSLAMWSILAVGffN 334
Cdd:cd17329 234 GE------SLLGLLLALNAllivllqfpVARLVE--RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG--E 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 918231292 335 SIMFPTIFTLA-----IRGLGEYTGRGSGylcQGIVGGAILPLLQGFAADAMGLQMSFLIPAI 392
Cdd:cd17329 304 MLVFPAVQTLVaalapPDKRGSYMGFYAL---AWGLGRAIGPLVGGLLLDLLGPGLPWLILAA 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-165 |
1.35e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 29 LFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFYPAAE 108
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 918231292 109 ISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGP 165
Cdd:pfam07690 288 TLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-134 |
1.44e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.62 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 19 ARFALMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIAS 98
Cdd:cd17321 167 ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246
|
90 100 110
....*....|....*....|....*....|....*.
gi 918231292 99 GCVLFYPAAEISMYPLFLFALFVLASGVTMLQVSAN 134
Cdd:cd17321 247 GLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLT 282
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
56-401 |
1.53e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 56 FQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVV--GLLTIASGCVLFYPAAEISMYPLFLFALFVLASGVTMLQVSA 133
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPAR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 134 NPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILAAtseagsakSVQTPYLIIAGALVIVALLFLKMKLPNISE 213
Cdd:cd06173 114 QALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALL--------GPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 214 HVEKDQASPPFSLFAHKHLY---------LGVLAIFLYVGAEVSIGSYLVNLFMQLGidnmnEVTAGKMVSYYWGAAMVG 284
Cdd:cd06173 186 PGESSSLLLRDLREGLRYLRrspllrlllLALALFALLGGALTVLLPLLAKEVLGGG-----AAGYGLLLAAFGVGALLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 285 RFIGAAILNFIKATTLLAINAVL-AISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFTLAIRGL-GEYTGRGSGYLCQ 362
Cdd:cd06173 261 ALLLGRLSKRRRRGRLLLIGALLlGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVpDELRGRVFSVYNA 340
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 918231292 363 GIVGGAIL-PLLQGFAADAMGLQMSFLIPAISYLYIAWYA 401
Cdd:cd06173 341 LNSGAMPLgALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
43-398 |
2.01e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.98 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 43 LLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLfypAAEISMYPLFLFALFVL 122
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL---CGFAQNYWQLLILRALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 123 ASGVTMLQVSANPYVAVLGPESTAASRLNLAQAinsvGHTAGPMFGALLILAATSEAGSAKSVQtpYLIIAGALVIVALL 202
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPARHRGKALGYVQS----GWAVGWLLATLLAALLFPLLPPEIAWR--VLFLLGALPALLVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 203 FLKMKLPNISE-------HVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEvsIGSYLVNLFMQL---GIDNMNEVTAGK 272
Cdd:cd17371 172 FIRRFVKEPPQwqaaraaRRHFADRPSLRELFSPPLLRTTLLASLLATGAL--GGYYGITTWLPSyltGERGLSFEGSAG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 273 MVSYYWGAAMVGRFIGAAILNFIKATTLLAINAVLAISMIVIAVNMEGS--LAMWSILAVGFFNSIMF-------PTIFT 343
Cdd:cd17371 250 YLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSptLILILGFPLGFFASGPFsgmgaylTELFP 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 918231292 344 LAIRGlgeyTGRGSGYLCqGIVGGAILPLLQGFAADAMGLQMSFLIPAISYLYIA 398
Cdd:cd17371 330 TAVRA----TAQGFCYNV-GRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAG 379
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
43-285 |
2.26e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 39.91 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 43 LLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIAsgcVLFYPAAEISMYPLFLFALFVL 122
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMG---AAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 123 ASGVTMLQVSANPYVAvlgpESTAASRLNLAQAINSVGHTAGPMFGALLILAATSEAGSAKSVQTPYLIIAGALVIVALL 202
Cdd:cd17475 95 GAGYGSVQPGGGRAIM----RWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 203 FLKMKLPNISEHVEKDQASPPFSLFAHKHLYLGVLAIFLYVGAEVSIGSYLVNLFM-QLGIdnmNEVTAGKMVSYYWGAA 281
Cdd:cd17475 171 YREPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHdHLGL---SVVAAGALLAVAQLGG 247
|
....
gi 918231292 282 MVGR 285
Cdd:cd17475 248 ALGR 251
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-207 |
4.53e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.09 E-value: 4.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 10 RQPSPAAFNARFALMVMTSLFFIWGFITALNdILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGI 89
Cdd:COG2223 196 RDQLEALRDPRFWLLSLLYFGTFGSFIGFSS-WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 90 VVGLLTIASGCVLFypAAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGA 169
Cdd:COG2223 275 LIVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFG 352
|
170 180 190
....*....|....*....|....*....|....*...
gi 918231292 170 LLIlaatseaGSAKSVQTPYLIIAGALVIVALLFLKMK 207
Cdd:COG2223 353 ALL-------DATGSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
49-395 |
4.73e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 4.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 49 NAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVLFYpaaeISMYPLFLFALFVLASGVTM 128
Cdd:cd17330 27 NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG----LSRNLWLLFLARFLDGLTGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 129 LQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLIlaatseagSAKSVQTPYLIIAgALVIVALLFLKMKL 208
Cdd:cd17330 103 NVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS--------TPYGYALPFLVAA-ALALLNLVLVLFFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 209 PNISehvekdqasppfslfahKHLYLGVLAIFLYVGAEVSIGSYLVNLFmqlgidNMNEVTAGKMVSYYWGAAMVGRFIG 288
Cdd:cd17330 174 PPLR-----------------RLLLVYFLIALAFAGLESVFSLFLKDRF------GFSPSQIGLLLALVGIAGILAQLLL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 289 AAILNFI--KATTLLAINAVLAISMIVIAVNMEGSLAMWSILAVGFFNSIMFPTIFTLAIRGLG-EYTGRGSGyLCQGIV 365
Cdd:cd17330 231 IPRLAKRlgERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPsKEQGKAQG-IIQSLQ 309
|
330 340 350
....*....|....*....|....*....|..
gi 918231292 366 GGA--ILPLLQGFAADAMGLQMSFLIPAISYL 395
Cdd:cd17330 310 SLAriIGPLLAGPLYSFLGPGVPFLLAAGLLL 341
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-206 |
5.60e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 5.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 20 RFALMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASG 99
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 100 CVLFypaAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILAAtsea 179
Cdd:cd06173 288 LLVL---GLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL---- 360
|
170 180
....*....|....*....|....*..
gi 918231292 180 gsakSVQTPYLIIAGALVIVALLFLKM 206
Cdd:cd06173 361 ----GLSAVFLLAGALLLLAALLLLLL 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-204 |
6.32e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 38.31 E-value: 6.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 23 LMVMTSLFFIWGFITALNDILLPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCVL 102
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALAL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 103 FYPAAEISMYpLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLIlaatseagSA 182
Cdd:COG2271 263 LLLALLPSPA-LAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL--------DA 333
|
170 180
....*....|....*....|..
gi 918231292 183 KSVQTPYLIIAGALVIVALLFL 204
Cdd:COG2271 334 TGYQAAFLLLAALALLAALLAL 355
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-203 |
6.33e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 38.30 E-value: 6.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 22 ALMVMTSLFFIWGFITalndillPYLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGCV 101
Cdd:cd17324 207 TFLLFGGFFALYTYLA-------PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 102 LFYPAAEIsmyPLFLFALFVLASGVTMLQVSANPYVAVLGPESTA-ASRLNLAqAINsVGHTAGPMFGALLILAATSEAg 180
Cdd:cd17324 280 LTLLGPSP---LLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGlASSLYLA-AYN-LGGALGAALGGLVLDHGGWAG- 353
|
170 180
....*....|....*....|...
gi 918231292 181 saksvqtpYLIIAGALVIVALLF 203
Cdd:cd17324 354 --------VGWVGAALLLLALLL 368
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
22-206 |
9.24e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 37.98 E-value: 9.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 22 ALMVMTSLFFIWGFITALNDILLP-YLKNAFSLTYFQAGLVQFCFFGAYFIVSPFAGRFLEKIGYKKGIVVGLLTIASGC 100
Cdd:cd17329 201 AFLLFLLASFLISLIYFQLESTLPvYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGF 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 918231292 101 VLFypaAEISMYPLFLFALFVLASGVTMLQVSANPYVAVLGPESTAASRLNLAQAINSVGHTAGPMFGALLILAATSEAg 180
Cdd:cd17329 281 AVL---AFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL- 356
|
170 180
....*....|....*....|....*.
gi 918231292 181 saksvqtPYLIIAGALVIVALLFLKM 206
Cdd:cd17329 357 -------PWLILAALGLIAAALLLGL 375
|
|
| |
