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Conserved domains on  [gi|919225954|ref|WP_052776093|]
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MULTISPECIES: sulfite oxidase heme-binding subunit YedZ [Campylobacter]

Protein Classification

sulfite oxidase heme-binding subunit YedZ( domain architecture ID 10006555)

sulfite oxidase subunit YedZ is a heme binding inner membrane protein which may be involved in electron transfer between its heme and the molybdenum cofactor of the catalytic subunit YedY

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MsrQ super family cl43704
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 68-149 5.37e-12

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


The actual alignment was detected with superfamily member COG2717:

Pssm-ID: 442030  Cd Length: 200  Bit Score: 61.73  E-value: 5.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919225954  68 LGIFAAFWAILHFLNYFIFDRNAQISRLFDDISHRLLEASGFIAFLIIFLMLLSSFKIFkklskIRKLG----------Y 137
Cdd:COG2717   77 LGLWAFFYALLHLLAYLWLDLGFDLALIWADIVKRPYITVGFAAFLLLLPLALTSTNAA-----IRRLGrrwkrlhrlvY 151

                         90
                 ....*....|..
gi 919225954 138 LCLVLASYHYFL 149
Cdd:COG2717  152 LAAVLAVLHFFW 163
 
Name Accession Description Interval E-value
MsrQ COG2717
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 68-149 5.37e-12

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 442030  Cd Length: 200  Bit Score: 61.73  E-value: 5.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919225954  68 LGIFAAFWAILHFLNYFIFDRNAQISRLFDDISHRLLEASGFIAFLIIFLMLLSSFKIFkklskIRKLG----------Y 137
Cdd:COG2717   77 LGLWAFFYALLHLLAYLWLDLGFDLALIWADIVKRPYITVGFAAFLLLLPLALTSTNAA-----IRRLGrrwkrlhrlvY 151

                         90
                 ....*....|..
gi 919225954 138 LCLVLASYHYFL 149
Cdd:COG2717  152 LAAVLAVLHFFW 163
PRK05419 PRK05419
protein-methionine-sulfoxide reductase heme-binding subunit MsrQ;
68-152 3.82e-09

protein-methionine-sulfoxide reductase heme-binding subunit MsrQ;


Pssm-ID: 235452  Cd Length: 205  Bit Score: 53.71  E-value: 3.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919225954  68 LGIFAAFWAILHFLNYFIFDRNAQISRLFDDISHRLLEASGFIAFLIIFLMLLSSFKIF-----KKLSKIRKLGYLCLVL 142
Cdd:PRK05419  80 LGLWAFFYATLHLLSYLLLDLGLDWSLLGKEIVKRPYITVGMAAFLILLPLALTSTRASqrrlgKRWQKLHRLVYLIAIL 159

                         90
                 ....*....|
gi 919225954 143 ASYHYFLTPK 152
Cdd:PRK05419 160 APLHYLWSVK 169
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 66-130 3.87e-03

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 35.71  E-value: 3.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 919225954   66 KILGIFAAFWAILHFLNYFIFDRNAQISRLFDDISHRLLEASGFIAFLIIFLMLLSSFKIFKKLS 130
Cdd:pfam01794  38 RWLGRLAFLLALLHVILYLIYWLRFSLEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRRLS 102
 
Name Accession Description Interval E-value
MsrQ COG2717
Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide ...
 68-149 5.37e-12

Heme-binding membrane subunit of periplasmic DMSO/TMAO and protein-methionine-sulfoxide reductases [Energy production and conversion];


Pssm-ID: 442030  Cd Length: 200  Bit Score: 61.73  E-value: 5.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919225954  68 LGIFAAFWAILHFLNYFIFDRNAQISRLFDDISHRLLEASGFIAFLIIFLMLLSSFKIFkklskIRKLG----------Y 137
Cdd:COG2717   77 LGLWAFFYALLHLLAYLWLDLGFDLALIWADIVKRPYITVGFAAFLLLLPLALTSTNAA-----IRRLGrrwkrlhrlvY 151

                         90
                 ....*....|..
gi 919225954 138 LCLVLASYHYFL 149
Cdd:COG2717  152 LAAVLAVLHFFW 163
PRK05419 PRK05419
protein-methionine-sulfoxide reductase heme-binding subunit MsrQ;
68-152 3.82e-09

protein-methionine-sulfoxide reductase heme-binding subunit MsrQ;


Pssm-ID: 235452  Cd Length: 205  Bit Score: 53.71  E-value: 3.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919225954  68 LGIFAAFWAILHFLNYFIFDRNAQISRLFDDISHRLLEASGFIAFLIIFLMLLSSFKIF-----KKLSKIRKLGYLCLVL 142
Cdd:PRK05419  80 LGLWAFFYATLHLLSYLLLDLGLDWSLLGKEIVKRPYITVGMAAFLILLPLALTSTRASqrrlgKRWQKLHRLVYLIAIL 159

                         90
                 ....*....|
gi 919225954 143 ASYHYFLTPK 152
Cdd:PRK05419 160 APLHYLWSVK 169
COG4097 COG4097
Predicted ferric reductase [Inorganic ion transport and metabolism];
66-171 2.60e-03

Predicted ferric reductase [Inorganic ion transport and metabolism];


Pssm-ID: 443273 [Multi-domain]  Cd Length: 442  Bit Score: 37.57  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 919225954  66 KILGIFAAFWAILHFLNYFIFDRNAQISRL------FDDISHRLLEASGFIAF-LIIFLMLLSSFKifKKLS-----KIR 133
Cdd:COG4097   82 KWLGILALVLALAHPLLLLGPKWLVGWGGLparlaaLLTLLRGLAELLGEWAFyLLLALVVLSLLR--RRLPyelwrLTH 159

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 919225954 134 KLGYLCLVLASYHYFLTPKVPMFWEWSALIVALFYFIV 171
Cdd:COG4097  160 RLLAVAYLLLAFHHLLLGGPFYWSPPAGVLWAALAAAG 197
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 66-130 3.87e-03

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 35.71  E-value: 3.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 919225954   66 KILGIFAAFWAILHFLNYFIFDRNAQISRLFDDISHRLLEASGFIAFLIIFLMLLSSFKIFKKLS 130
Cdd:pfam01794  38 RWLGRLAFLLALLHVILYLIYWLRFSLEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRRLS 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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