|
Name |
Accession |
Description |
Interval |
E-value |
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-804 |
0e+00 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 1566.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 1 MGYNHKEIEKKWQNYWTDNKTFKTSDNLGQKKFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDA 80
Cdd:COG0495 3 ERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDMFPYPSGR-LHMGHVRNYTIGDVVARYKRMQGYNVLHPMGWDA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 81 FGLPAEQYALDTGNDPREFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPA 160
Cdd:COG0495 82 FGLPAENAAIKNGVHPAEWTYENIANMRRQLKRLGLSYDWSREIATCDPEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 161 LGTVLSNEEVVDGVSERGGHPVYRRPMKQWVLKITEYADRLLEDLDELD-WPESIKDMQRNWIGRSEGASVSFKVDNSDE 239
Cdd:COG0495 162 DQTVLANEQVIDGRCWRCGAPVEKKELPQWFLKITDYADELLDDLDKLDgWPEKVKTMQRNWIGRSEGAEVDFPVEGSDE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 240 SIDVFTTRPDTIYGTTFLVLSPEHALVNKITSADKLETVKQYQEEASKKSDLERTDLAKDKSGVFTGAYAINPLSGETLP 319
Cdd:COG0495 242 KITVFTTRPDTLFGATFMVLAPEHPLVKELATPEQNAAVAAFIEEAKKKSEIERTSETKEKTGVFTGLYAINPLTGEKIP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 320 IWIADYVLSSYGTGAVMAVPAHDERDYEFASKFNLPINEVIAGGD-----IQKEAYTGVGEHINSGELNGLDNEAAISKA 394
Cdd:COG0495 322 IWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIAPEDgddpdILEEAYTGDGVLINSGEFDGLDSEEAKEAI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 395 IELLVAKGAGEKKVNYKLRDWLFSRQRYWGEPIPVIHWEDGSMTTVPEDELPLLLPETDEIKPsgTGESPLANIDEFVNV 474
Cdd:COG0495 402 IEWLEEKGLGKRKVNYRLRDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQLPVELPEDVDFDP--TGGSPLARAPEWVNV 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 475 VDEKTGMKGRRETNTMPQWAGSCWYYLRYIDPNNSKMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLFDLGVV 554
Cdd:COG0495 480 TCPKCGGPARRETDTMDTFVDSSWYYLRYTDPHNDEAPFDPEAANYWLPVDQYIGGIEHAILHLLYARFFTKVLRDLGLV 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 555 PTKEPFQKLYNQGMIL--------GEGNEKMSKSKGNVVNPDDIVNSHGADTLRLYEMFMGPLDAAIAWSENGLDGSRRF 626
Cdd:COG0495 560 SFDEPFKRLLTQGMVLevgkdgvvIGGIEKMSKSKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRF 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 627 LDRVWRLFINEDGSLTDKVVENN--DTKLDKVFNQTVKKVTEDFNSLNFNTAISQLMVFINECYKSET-------IYKPY 697
Cdd:COG0495 640 LNRVWRLVVDEAEALKLDVADLSeaDKELRRALHKTIKKVTEDIERLRFNTAIAALMELVNALYKAKDsgeadraVLREA 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 698 AEGFIKMLAPIAPHIGEELWNRLGNDDTITYQPWPTYDESLLVDAEVEIVVQVNGKVRAKMNIPKDTSKDEMEALALQDE 777
Cdd:COG0495 720 LETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEADEAALVEDEVTIVVQVNGKVRGKIEVPADASKEELEAAALADE 799
|
810 820
....*....|....*....|....*..
gi 920628917 778 NVKLSIEGKDIKKVIAVPQKLVNIVAK 804
Cdd:COG0495 800 KVQKFLEGKTIRKVIVVPGKLVNIVVK 826
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
2-804 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 1292.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 2 GYNHKEIEKKWQNYWTDNKTFKTSD--NLGQKKFYALDMFPYPSGAGLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWD 79
Cdd:PLN02563 79 AYPFHEIEPKWQRYWEENRTFRTPDdvDTSKPKFYVLDMFPYPSGAGLHVGHPEGYTATDILARYKRMQGYNVLHPMGWD 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 80 AFGLPAEQYALDTGNDPREFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCP 159
Cdd:PLN02563 159 AFGLPAEQYAIETGTHPKITTLKNIARFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCP 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 160 ALGTVLSNEEVVDGVSERGGHPVYRRPMKQWVLKITEYADRLLEDLDELDWPESIKDMQRNWIGRSEGASVSFKVDN--- 236
Cdd:PLN02563 239 ALGTVLANEEVVDGLSERGGHPVIRKPMRQWMLKITAYADRLLEDLDDLDWPESIKEMQRNWIGRSEGAELDFSVLDgeg 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 237 --SDESIDVFTTRPDTIYGTTFLVLSPEHALVNKITSADKLETVKQYQEEASKKSDLERTDLAKDKSGVFTGAYAINPLS 314
Cdd:PLN02563 319 keRDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRKSDLERTELQKEKTGVFTGSYAINPAT 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 315 GETLPIWIADYVLSSYGTGAVMAVPAHDERDYEFASKFNLPINEVIAGGDI----QKEAYTGVGEHINSGE----LNGLD 386
Cdd:PLN02563 399 GEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGneddAEKAYTGEGVIVNSSSsgldINGLS 478
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 387 NEAAISKAIELLVAKGAGEKKVNYKLRDWLFSRQRYWGEPIPVIHWED-GSMTTVPEDELPLLLPETDEIKPSGTGESPL 465
Cdd:PLN02563 479 SKEAAKKVIEWLEETGNGKKKVNYKLRDWLFARQRYWGEPIPVVFLEDsGEPVPVPESDLPLTLPELDDFTPTGTGEPPL 558
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 466 ANIDEFVNVVDEKTGMKGRRETNTMPQWAGSCWYYLRYIDPNNSKMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWH 545
Cdd:PLN02563 559 AKAVSWVNTVDPSSGKPARRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWH 638
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 546 KVLFDLGVVPTKEPFQKLYNQGMILGE----------GN----------------------------------------- 574
Cdd:PLN02563 639 KVLYDIGVVSTKEPFQCLVNQGMILGEveytafkdsdGEyvsadtadrlgelqqekipeekviksgdsfvlkddpsirli 718
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 575 ---EKMSKSKGNVVNPDDIVNSHGADTLRLYEMFMGPLDAAIAWSENGLDGSRRFLDRVWRLFI---NEDGSLTDKVVEN 648
Cdd:PLN02563 719 araHKMSKSRGNVVNPDDVVSEYGADSLRLYEMFMGPLRDSKTWSTSGVEGVHRFLGRTWRLVVgapLPDGSFRDGTVVT 798
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 649 N---DTKLDKVFNQTVKKVTEDFNSLNFNTAISQLMVFINECYKSETIYKPYAEGFIKMLAPIAPHIGEELWNRLGNDDT 725
Cdd:PLN02563 799 DeepSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAYKWDKVPREAIEPFVLLLSPYAPHLAEELWFRLGHSNS 878
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 920628917 726 ITYQPWPTYDESLLVDAEVEIVVQVNGKVRAKMNIPKDTSKDEMEALALQDENVKLSIEGKDIKKVIAVPQKLVNIVAK 804
Cdd:PLN02563 879 LAYEPWPEANPSYLVDDTVVLPVQINGKTRGTIEVEEGCSEDDAFALASQDEKLSKYLDGKEIKKRIYVPGKILNVILK 957
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
3-804 |
0e+00 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 1262.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 3 YNHKEIEKKWQNYWTDNKTFKTSDNLGQKKFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFG 82
Cdd:TIGR00396 1 YNHIEIEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGA-LHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 83 LPAEQYALDTGNDPREFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALG 162
Cdd:TIGR00396 80 LPAENAAIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 163 TVLSNEEVV-DGVSERGGHPVYRRPMKQWVLKITEYADRLLEDLDELD-WPESIKDMQRNWIGRSEGASVSFKVDNSDES 240
Cdd:TIGR00396 160 TVLANEQVDsDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDhWPESVKEMQRNWIGKSEGVEITFKIADHDEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 241 IDVFTTRPDTIYGTTFLVLSPEHALVNKITSADKleTVKQYQEEASKKSDLERTDLAKDKSGVFTGAYAINPLSGETLPI 320
Cdd:TIGR00396 240 ITVFTTRPDTIFGVTYLALAPEHPLVEKAAENNP--KVAAFIKKILNKTVAERTKATKEKKGVDTGIKAIHPLTGEKIPI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 321 WIADYVLSSYGTGAVMAVPAHDERDYEFASKFNLPINEVIAGGD---IQKEAYTGVGEHINSGELNGLDNEAAISKAIEL 397
Cdd:TIGR00396 318 WVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEkdlSLTAAYTEDGVLVNSGEFNGLNSSEARNAIIDM 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 398 LVAKGAGEKKVNYKLRDWLFSRQRYWGEPIPVIHWEDGSMTTVPEDELPLLLPETDEIKPSgtGESPLANIDEFVNVVDE 477
Cdd:TIGR00396 398 LEKEGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGD--GGSPLSRIPEWVNVTCP 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 478 KTGMKGRRETNTMPQWAGSCWYYLRYIDPNNSKMLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLFDLGVVPTK 557
Cdd:TIGR00396 476 SCGKPALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTK 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 558 EPFQKLYNQGMILG-------------------------------EGNEKMSKSKGNVVNPDDIVNSHGADTLRLYEMFM 606
Cdd:TIGR00396 556 EPFKKLINQGMVLGfyyppngkvpadvlterdekgkdkaggelvyVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFM 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 607 GPLDAAIAWSENGLDGSRRFLDRVWRLFINEDG-----SLTDKVVENNDTKLDKVFNQTVKKVTEDFNSLN-FNTAISQL 680
Cdd:TIGR00396 636 GPIAASLEWNESGLEGARRFLDRVWNLVYEITGeldaaSLTVTALEEAQKELRRDVHKFLKKVTEDLEKREsFNTAISAM 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 681 MVFINECYKS--ETIYKPYAEGFIKMLAPIAPHIGEELWNRLGNDDTITYQ-PWPTYDESLLVDAEVEIVVQVNGKVRAK 757
Cdd:TIGR00396 716 MELLNKLYKAkkEALMLEYLKGFVTVLSPFAPHLAEELWEKLGSEPFIIDNaKWPVVDETALVEDKTLIVVQVNGKFRAK 795
|
810 820 830 840
....*....|....*....|....*....|....*....|....*..
gi 920628917 758 MNIPKDTSKDEMEALALQDENVKLSIEGKDIKKVIAVPQKLVNIVAK 804
Cdd:TIGR00396 796 ITVPKDADEEQVEELAKQDPEVKKYLENKTIKKVIYVPGKLVNFVIK 842
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
32-615 |
3.56e-127 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 382.75 E-value: 3.56e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 32 KFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQNIQTFKRQI 111
Cdd:cd00812 1 KFYILVMFPYPSGA-LHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 112 QELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCpalgtvlsneevvdgvsergghpvyrRPMKQWV 191
Cdd:cd00812 80 KRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC--------------------------KLLDQWF 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 192 LKI--TEYADRLLEDLDELD-WPEsikdmqrnwigrsegasvsfkvdnsdesidvfttrpdtiygttflvlspehalvnk 268
Cdd:cd00812 134 LKYseTEWKEKLLKDLEKLDgWPE-------------------------------------------------------- 157
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 269 itsadkleTVKQYQEEaskksdlertdlakdksgvftgayainplsgetlpiWIAdyvlssygtgavmavpahderdyef 348
Cdd:cd00812 158 --------EVRAMQEN------------------------------------WIG------------------------- 168
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 349 askfnlpineviaggdiqkeaytgvgehinsgelngldneaaiskaiellvakgagekkvnyklrdwlFSRQRYWGEPIP 428
Cdd:cd00812 169 --------------------------------------------------------------------CSRQRYWGTPIP 180
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 429 VihwedgsmttvpedelplllpetdeikpsgtgesplanidefvnvvdektgmkgrreTNTMPQWAGSCWYYLRYIDPNN 508
Cdd:cd00812 181 W---------------------------------------------------------TDTMESLSDSTWYYARYTDAHN 203
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 509 SK------MLADPEKLKHWLPVDLYIGGVEHAVLHLLYARFWHKVLFDLGVVpTKEPFQKLYNQGMILGEGnEKMSKSKG 582
Cdd:cd00812 204 LEqpyegdLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLLEG-EKMSKSKG 281
|
570 580 590
....*....|....*....|....*....|...
gi 920628917 583 NVVNPDDIVNSHGADTLRLYEMFMGPLDAAIAW 615
Cdd:cd00812 282 NVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
3-795 |
3.93e-102 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 335.11 E-value: 3.93e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 3 YNHKEIEKKWQNYWTDNKTFKTSDNLGQKKFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFG 82
Cdd:TIGR00422 5 YDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGS-LHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 83 LPA----EQYALDTGND----PRE--------FTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKG 146
Cdd:TIGR00422 84 IATqvkvEKKLGAEGKTkhdlGREefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 147 LAYVDEVAVNWCPALGTVLSNEEVVdgVSERGGHPVYrrpmkqwvlkiteyadrlledldeldwpesikdmqrnwigrse 226
Cdd:TIGR00422 164 LIYRGEYLVNWDPKLNTAISDIEVE--YKEVKGKLYY------------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 227 gasVSFKVDNSDES-IDVFTTRPDTIYGTTFLVLSPEHalvnkitsadkletvKQYQEeaskksdlertdlakdksgvFT 305
Cdd:TIGR00422 199 ---IRYPLANGSKDyLVVATTRPETMFGDTAVAVHPED---------------ERYKH--------------------LI 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 306 GAYAINPLSGETLPIwIAD-YVLSSYGTGAVMAVPAHDERDYEFASKFNLP-INEVIAGGDIQKEAytgvgehinsGELN 383
Cdd:TIGR00422 241 GKKVILPLTGRKIPI-IADeYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEfINILDEDGLLNENA----------GKYQ 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 384 GLDNEAAISKAIELLVAKGAGEKKVNYK---------------------------------------------------- 411
Cdd:TIGR00422 310 GLTRFEARKKIVEDLKEEGLLVKIEPHThnvgtcwrsgtvvepllskqwfvkvekladkaleaaeegeikfvpkrmekry 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 412 ------LRDWLFSRQRYWGEPIPV-IHWEDGSMTTVPEDELPlllpetdeIKPSGTGESPlanidEFvnvvdektgmkgR 484
Cdd:TIGR00422 390 lnwlrnIKDWCISRQLIWGHRIPVwYCKECGEVYVAKEEPLP--------DDKTNTGPSV-----EL------------E 444
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 485 RETNTMPQWAGSCWYYLRYID-PNNSKmladpeKLKHWLPVDLYIGGveHAVLhllyaRFWHKVLFDLGVVPTKE-PFQK 562
Cdd:TIGR00422 445 QDTDVLDTWFSSSLWPFSTLGwPDETK------DLKKFYPTDLLVTG--YDII-----FFWVARMIFRSLALTGQvPFKE 511
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 563 LYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRLYEMFMGPLDAAIAWSENGLDGSRRFLDRVWRLF----INED 638
Cdd:TIGR00422 512 VYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASrfvlMNLS 591
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 639 GSLTDKVVENNDTKLDK----VFNQTVKKVTEDFNSLNFNTAISQLMVFI-------------NECYKSETIYKPYA--- 698
Cdd:TIGR00422 592 DDLELSGGEEKLSLADRwilsKLNRTIKEVRKALDKYRFAEAAKALYEFIwndfcdwyielvkYRLYNGNEAEKKAArdt 671
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 699 -----EGFIKMLAPIAPHIGEELWNRLGND-DTITYQPWPTYDESLL---VDAEVEIVVQVNGKVR---AKMNIPKD--- 763
Cdd:TIGR00422 672 lyyvlDKALRLLHPFMPFITEEIWQHFKEGaDSIMLQSYPVVDAEFVdeeAEKAFELLKEIIVSIRnlkAESNIPPNapl 751
|
890 900 910
....*....|....*....|....*....|....*...
gi 920628917 764 ------TSKDEMEALALQDENVKLSIEGKDIKKVIAVP 795
Cdd:TIGR00422 752 kvlliyTEAETAERLKLNAVDIKGAINFSEVEVVIEKP 789
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
3-755 |
5.10e-90 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 300.96 E-value: 5.10e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 3 YNHKEIEKKWQNYWTDNKTFKTSDNlGQKKFYALDMFP-YPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAF 81
Cdd:PRK13208 10 YDPEELEEKWQKIWEEEGTYKFDPD-ERKPVYSIDTPPpTVSGS-LHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWDDN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 82 GLPAE---QYALDTGNDP----------REFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLA 148
Cdd:PRK13208 88 GLPTErkvEKYYGIRKDDisreefielcRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLYKKGLI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 149 YVDEVAVNWCPALGTVLSNEEVVDgvSERGGHPVYrrpmkqwvlkiteyadrlledldeldwpesikdmqrnwigrsega 228
Cdd:PRK13208 168 YRAEAPVLWCPRCETAIAQAEVEY--REREGKLNY--------------------------------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 229 sVSFKVDnSDESIDVFTTRPDTIYGTTFLVLSPEhalvnkitsaDkletvkqyqeeaskksdlER-TDLAkdksgvftGA 307
Cdd:PRK13208 201 -IKFPVE-DGEEIEIATTRPELLPACVAVVVHPD----------D------------------ERyKHLV--------GK 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 308 YAINPLSGETLPIwIAD-YVLSSYGTGAVMAVPAHDERDYEFASKFNLPINEVI-AGGDIqKEAYtgvgehinsGELNGL 385
Cdd:PRK13208 243 TAIVPLFGVEVPI-LADpLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIdEDGRM-TEAA---------GKLAGL 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 386 DNEAAISKAIELLVAKGA-GEKK-----VN-----------------------------------------YKLR----- 413
Cdd:PRK13208 312 TIEEARKKIVEDLKSGGLlGKQEpikhnVKfcercdtpleilvtrqwfikvldlkeellergkeinwypehMRVRlenwi 391
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 414 -----DWLFSRQRYWGEPIPVihW---EDGSMTTVPEDELPlLLPETDEikPSGTGEsPLANIDEFVNvvdektgmkgrr 485
Cdd:PRK13208 392 eglnwDWCISRQRYFGTPIPV--WyckDCGHPILPDEEDLP-VDPTKDE--PPGYKC-PQCGSPGFEG------------ 453
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 486 ETNTMPQWAGSCwyylryIDP-NNSKMLADPEKLKHWLPVDLYIGGveHAVLhllyaRFWH-----KVLFDLGVVPTKEp 559
Cdd:PRK13208 454 ETDVMDTWATSS------ITPlIVTGWERDEDLFEKVFPMDLRPQG--HDII-----RTWLfytilRAYLLTGKLPWKN- 519
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 560 fqKLYNqGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRlYEMFMGPLDAAIAWSENGLDGSRRFLDRVWR-----LF 634
Cdd:PRK13208 520 --IMIS-GMVLDPDGKKMSKSKGNVVTPEELLEKYGADAVR-YWAASARLGSDTPFDEKQVKIGRRLLTKLWNasrfvLH 595
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 635 INEDGSLTDKVVENndtKLDKVF----NQTVKKVTEDFNSLNFNTAISQLMVFI-------------NECYKSETIYKPY 697
Cdd:PRK13208 596 FSADPEPDKAEVLE---PLDRWIlaklAKVVEKATEALENYDFAKALEEIESFFwhvfcddylelvkSRAYGEDEEEEQK 672
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 698 A---------EGFIKMLAPIAPHIGEELWNRLGNDDTITyQPWPTYDESLLVDA---EVEIVVQVNGKVR 755
Cdd:PRK13208 673 SarytlytvlDTLLRLLAPFLPFITEEVWSWLYGGSVHR-ASWPEPDEELIDEEdeeLGELAKEILSAVR 741
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
219-398 |
4.95e-89 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 278.66 E-value: 4.95e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 219 RNWIGRSEGASVSFKVDNSDESIDVFTTRPDTIYGTTFLVLSPEHALVNKItsADKLETVKQYQEEASKKSDLERTDLAK 298
Cdd:pfam13603 1 RNWIGRSEGAEITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKL--AEKNPEVAAFIEECKNTSEIERTSETK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 299 DKSGVFTGAYAINPLSGETLPIWIADYVLSSYGTGAVMAVPAHDERDYEFASKFNLPINEVIAGGD------IQKEAYTG 372
Cdd:pfam13603 79 EKEGVFTGLYAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQPEDgdldldIMTEAYTE 158
|
170 180
....*....|....*....|....*.
gi 920628917 373 VGEHINSGELNGLDNEAAISKAIELL 398
Cdd:pfam13603 159 EGILVNSGEFDGLDSEEAKEAIIKKL 184
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
11-616 |
1.81e-70 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 243.09 E-value: 1.81e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 11 KWQNYWTDNKTFKTSDNL--GQKKFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQ- 87
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKrkGKPSFTIHDGPPNATGS-LHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQv 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 88 ----YALDTGNDP------------REFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVD 151
Cdd:pfam00133 80 vekkLGIKEKKTRhkygreefrekcREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 152 EVAVNWCPALGTVLSNEEVvdgvsergghpvyrrpmkqwvlkitEYADrlledldeldwpesikdmqrnwigrSEGAS-- 229
Cdd:pfam00133 160 KKLVNWSPALNTALSNLEV-------------------------EYKD-------------------------VKGPSih 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 230 VSFKVDNSDE-SIDVFTTRPDTIYGTTFLVLSPEHALVNKitsaDKLETVKQYQEEASKKSDLERTDLAKDKSGVFTGAY 308
Cdd:pfam00133 190 VAFPLADDEGaSLVIWTTTPWTLPGNTAVAVNPEFDYVIT----GEGYILAEALLKSLYKKGTDKKILEDFRGKELEGKE 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 309 AINPLSGETLPIWIADYVLSSYGTGAVMAVPAHDERDYEFASKFNLP-INEVIAGGDIQKEAytgvgehinsGELNGLDN 387
Cdd:pfam00133 266 AIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEvINPVDDDGTFTEEA----------PDFQGVYR 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 388 EAAISKAIELLVAKGA----------------GEKKVNYKL--------------------------------------- 412
Cdd:pfam00133 336 FDARKKIVELLTEKGLllkiepfthsypfcwrSGTPIIPRAtpqwfvrmdeladqaleavekvqfvpksgekryfnwlan 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 413 -RDWLFSRQRYWGEPIPVIHWEDGS---MTTVPEDELPLLLPETDEIKpsgtgesplANIDEFVNVVDEKTGMKgRRETN 488
Cdd:pfam00133 416 iQDWCISRQRWWGHPIPAWVSKDTEevvCRGELFELVAGRFEEEGSIK---------WLHREAKDKLGYGKGTL-EQDED 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 489 TMPQW--AGScWYYLRYIDPNNSKmladpEKLKHWLPVDLYIGGVEHavlhllyARFWHKVLFDLGVVPTKE-PFQKLYN 565
Cdd:pfam00133 486 VLDTWfsSGS-WPFSTLGWPFVNT-----EEFKKFFPADMLLEGSDQ-------TRGWFYRMIMLSTALTGSvPFKNVLV 552
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 920628917 566 QGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRLYeMFMGPLDAAIAWS 616
Cdd:pfam00133 553 HGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLW-LANSDYGRDINLS 602
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
3-762 |
7.27e-70 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 246.94 E-value: 7.27e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 3 YNHKEIEKKWQNYWTDNKTFKTSDNlgQKKFYALdMFPYPSGAG-LHVGHpeGYTAT--DIVSRYKRMQGYNVLhpmgWd 79
Cdd:PRK05729 9 YDPKEVEAKWYQKWEEKGYFKPDDN--SKKPFSI-VIPPPNVTGsLHMGH--ALNNTlqDILIRYKRMQGYNTL----W- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 80 afgLPA------------EQYALDTGNDPREFT------------QQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWT 135
Cdd:PRK05729 79 ---LPGtdhagiatqmvvERQLAAEGKSRHDLGrekflekvwewkEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 136 QWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVvdgvsergghpvyrrpmkqwvlkitEYADRlledldeldwpesik 215
Cdd:PRK05729 156 REVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV-------------------------EYKEV--------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 216 dmqrnwigrsEGASVSFK--VDNSDESIDVFTTRPDTIYGTTFLVLSPEhalvnkitsadkletvkqyqeeaskksDlER 293
Cdd:PRK05729 196 ----------KGKLWHIRypLADGSDYLVVATTRPETMLGDTAVAVNPE---------------------------D-ER 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 294 -TDLAkdksgvftGAYAINPLSGETLPIwIAD-YVLSSYGTGAVMAVPAHDERDYEFASKFNLPINEVIaggdiQKEAyt 371
Cdd:PRK05729 238 yKHLI--------GKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIM-----DEDG-- 301
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 372 gvgeHINS--GELNGLDNEAA---ISKAIE---LLV----------------------------------AKGAGE---- 405
Cdd:PRK05729 302 ----TINEnpGEYQGLDRFEArkaIVADLEelgLLVkiephthsvghsdrsgvviepylsdqwfvkmkplAKPALEaven 377
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 406 ----------KKVNY----KLRDWLFSRQRYWGEPIPVIHWEDGSMTtVPEDElplllpetdeikpsgtgESPLANI--- 468
Cdd:PRK05729 378 geikfvperwEKTYFhwmeNIQDWCISRQLWWGHRIPAWYDEDGEVY-VGREE-----------------PEAREKAllt 439
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 469 -DEfvNVVDekT----GMkgrretntmpqWAGSC--WyylryidPNNSkmladpEKLKHWLPVDLYIGGVEhavlhLLYa 541
Cdd:PRK05729 440 qDE--DVLD--TwfssAL-----------WPFSTlgW-------PEKT------EDLKRFYPTSVLVTGFD-----IIF- 485
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 542 rFWhkV-------LFDLGvvptKEPFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRLYEMFMGPLDAAIA 614
Cdd:PRK05729 486 -FW--VarmimmgLHFTG----QVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIR 558
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 615 WSENGLDGSRRFLDRVW---RL-FINEDGSLTDKVVENNDTKL-DK----VFNQTVKKVTEDFNSLNFNTAISQLMVFI- 684
Cdd:PRK05729 559 FDEERVEGYRNFANKLWnasRFvLMNLEGADVGELPDPEELSLaDRwilsRLNRTVAEVTEALDKYRFDEAARALYEFIw 638
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 685 ---------------NECYKSETIYKPYA--EGFIKMLAPIAPHIGEELWNRL---GNDDTITYQPWPTYDESLLVDAE- 743
Cdd:PRK05729 639 nefcdwylelakpvlQEAAKRATRATLAYvlEQILRLLHPFMPFITEELWQKLaplGIEESIMLAPWPEADEAIDEAAEa 718
|
890 900
....*....|....*....|....
gi 920628917 744 -----VEIVVQVNgKVRAKMNIPK 762
Cdd:PRK05729 719 efewlKELITAIR-NIRAEMNIPP 741
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
1-754 |
5.38e-67 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 238.81 E-value: 5.38e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 1 MGYNHKEIEKKWQNYWTDNKTFKTS--DNLGQKKFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGW 78
Cdd:TIGR00392 4 MRGNLSKREEKILAFWQENDIFEKVkkLNKGKPEFIFHDGPPYANGS-IHLGHALNKILKDIILRYKTMQGFNVTRKPGW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 79 DAFGLPAEQ----------------YALDTGNDP-REFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQ 141
Cdd:TIGR00392 83 DTHGLPIEHkvekklgisgkkeissLEIEEFREKcREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 142 LYNKGLAYVDEVAVNWCPALGTVLSNEEVvdgvsergghpvyrrpmkqwvlkitEYadrlledldeldwPESIKDMqrnw 221
Cdd:TIGR00392 163 AHEKGLLYRGLKPVYWSPRCRTALAEAEV-------------------------EY-------------KENYKDV---- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 222 igRSEGASVSFKVDNSDE--------SIDVFTTRPDTIYGTTFLVLSP--EHALVNKITSADKLETVKQYQEEASKKSDL 291
Cdd:TIGR00392 201 --KDPSIYVKFPVKKDKKtylkvklsSLLIWTTTPWTLPSNLAIAVHPdfEYALVQDNTKVEYFILAKKLVEKLYNKAGS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 292 ERTDLAKDKSGVFTGAYAINPLSG------ETLPIWI-ADYVLSSYGTGAVMAVPAHDERDYEFASKFNLPI-NEVIAGG 363
Cdd:TIGR00392 279 DYEIIKTFKGSDLEGLEYEHPLYDfvsqlkEGAPVVIgGDHVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVlSPVDEKG 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 364 DIQKEAYTGVGEHInsgELNGLDNEAAISKAIELLVAKG----AGE---------------------------------- 405
Cdd:TIGR00392 359 VYTEGVNDFQGRFV---KDADKDIIKANKIIIEQLKDKGlllkAEKithsyphcwrtktpviyrateqwfiktkdikdqm 435
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 406 ----KKVNYK--------------LRDWLFSRQRYWGEPIPVIHWEDGSMTTVPE--DELPLLLPETdeikpsgtgESPL 465
Cdd:TIGR00392 436 leqiKKVNWVpewgegrfgnwlenRPDWCISRQRYWGIPIPIWYCEDTGEPIVVGsiEELIELIELK---------GIDA 506
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 466 ANIDEFVNVVDEKT-----GMKGRRETNTMPQW--AGSCWYYLRYIDPNNskmladpEKLKHWLPVDLYIGGVEHavlhl 538
Cdd:TIGR00392 507 WFEDLHRDFLDKITlksgdGGEYRRVPDVLDVWfdSGSMPYASIHYPFEN-------EKFKEVFPADFILEGSDQ----- 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 539 lyARFWHKVLFDLGVVPT-KEPFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRLYeMFMGPLDAAIAWSE 617
Cdd:TIGR00392 575 --TRGWFYSSLAIGTALFgQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINKYGADILRLY-VASSDPWEDLRFSD 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 618 NGLDGSRRFLDRVWRL---FINEDGSLTDkvvENNDTKLDKV-------------FNQTVKKVTEDFNSLNFNTAISQLM 681
Cdd:TIGR00392 652 EILKQVVEKYRKIRWNtyrFLLTYANLDK---FDPLFNSVAVekfpeedrwilsrLNSLVEEVNEALEKYNFHKVLRALQ 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 682 VFINE----------------------CYKSETIYKPYAEGFIKMLAPIAPHIGEELWNRL---GNDDTITYQPWPTYDE 736
Cdd:TIGR00392 729 DFIVEelsnwyiriirdrlyceakdndKRAAQTTLYYALLTLVRLLAPFLPHTAEEIYQNLpggEEEESVHLNLWPEVDE 808
|
890
....*....|....*...
gi 920628917 737 SlLVDAEVEIVVQVNGKV 754
Cdd:TIGR00392 809 E-FIDEALEANMAIVREI 825
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
3-761 |
1.45e-61 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 223.39 E-value: 1.45e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 3 YNHKEIEKKWQNYWTDNKTFKtSDNLGQKKFYALdMFPYP--SGAgLHVGHPEGYTATDIVSRYKRMQGYNVL------- 73
Cdd:COG0525 7 YDPKEVEAKWYQYWEENGYFK-ADPDSDKEPFTI-VIPPPnvTGS-LHMGHALNNTLQDILIRYKRMQGYNTLwqpgtdh 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 74 --------------------HPMGWDAFglpaeqyaLDtgndpR--EFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEY 131
Cdd:COG0525 84 agiatqavverqlaeegksrHDLGREKF--------LE-----RvwEWKEESGGTITNQLRRLGASCDWSRERFTMDEGL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 132 YKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVvdgvsergghpvyrrpmkqwvlkitEYADRlledldeldwp 211
Cdd:COG0525 151 SKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEV-------------------------EHEEV----------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 212 esikdmqrnwigrsEGASVSFK--VDNSDESIDVFTTRPDTIYGTTFLVLSPEhalvnkitsadkletvkqyqeeaskks 289
Cdd:COG0525 195 --------------KGHLWHIRypLADGSGYIVVATTRPETMLGDTAVAVHPE--------------------------- 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 290 DlER-TDLAkdksgvftGAYAINPLSGETLPIwIAD-YVLSSYGTGAVMAVPAHDERDYEFASKFNLPINEVIaggdiQK 367
Cdd:COG0525 234 D-ERyKHLI--------GKTVILPLVGREIPI-IADeYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIL-----DE 298
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 368 EAytgvgeHINS--GELNGLDNEAAISKAIELLVAKGAGEKKVNYKL--------------------------------- 412
Cdd:COG0525 299 DG------TINEnaGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHsvghsdrsgtviepylsdqwfvkmkplakpaie 372
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 413 -------------------------RDWLFSRQRYWGEPIPVIHWEDGSMTtVPEDElplllPETDeikpsgtgesPLAN 467
Cdd:COG0525 373 avedgeikfvperwektyfhwmeniRDWCISRQLWWGHRIPAWYCPDGEVY-VARTE-----PEAC----------AKAG 436
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 468 IDEFvnvvdektgmkgRRETNTMPQWAGSC--------WyylryidPNNSkmladpEKLKHWLPVDLYIGG-------Ve 532
Cdd:COG0525 437 SVNL------------TQDEDVLDTWFSSAlwpfstlgW-------PEKT------EDLKYFYPTSVLVTGfdiiffwV- 490
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 533 havlhllyAR-------FWHKVlfdlgvvptkePFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRLYEMF 605
Cdd:COG0525 491 --------ARmimmglhFTGEV-----------PFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAA 551
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 606 MGPLDAAIAWSENGLDGSRRFLDRVW---RL-FINEDGSLTDKVVENNDTKL-DK----VFNQTVKKVTEDFNSLNFNTA 676
Cdd:COG0525 552 LASPGRDIKFDEERVEGYRNFANKLWnasRFvLMNLEGFDPGLDPDPEELSLaDRwilsRLNKTIAEVTEALEKYRFDEA 631
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 677 ISQLMVFI-NE-C-----------YKSETIYKPYA--------EGFIKMLAPIAPHIGEELWNRLGN---DDTITYQPWP 732
Cdd:COG0525 632 AQALYDFVwNEfCdwylelakprlYGGDEAAKRETratlvyvlEQILRLLHPFMPFITEEIWQKLPPrkeGESIMLAPWP 711
|
890 900 910
....*....|....*....|....*....|....*
gi 920628917 733 TYDESLL---VDAEVEIVVQVNGKVR---AKMNIP 761
Cdd:COG0525 712 EADEELIdeeAEAEFEWLKEVISAIRnirAEMNIP 746
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
47-804 |
2.35e-59 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 217.43 E-value: 2.35e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 47 LHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLP----AEQYA--------------------LDTGNDPRE---- 98
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERIArgdpetielykslygipeeeLEKFKDPEYivey 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 99 FTQQNIQTFKRqiqeLGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVVDGVSERg 178
Cdd:PRK12300 81 FSEEAKEDMKR----IGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEEPE- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 179 ghpvyrrpmkqwvlkITEYADRLLEDLDELDWPesikdmqrnwigrsegasvsfkvdnsdesidVFTTRPDTIYGTTFLV 258
Cdd:PRK12300 156 ---------------IVEYTLIKFEESEDLILP-------------------------------AATLRPETIFGVTNLW 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 259 LSP-----------EHALVNKiTSADKLetvkQYQEEASKKsdlertdLAKDKSGVFTGAYAINPLSGETLPIWIADYVL 327
Cdd:PRK12300 190 VNPdatyvkaevdgEKWIVSK-EAAEKL----SFQDRDVEI-------IEEIKGSELIGKKVKNPVTGKEVPILPADFVD 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 328 SSYGTGAVMAVPAHDERDY----------EFASKFNL------------PINEVIAGGDIQ----------------KEA 369
Cdd:PRK12300 258 PDNGTGVVMSVPAHAPYDYvalrdlkknkELLDVIEPiplievegygefPAKEVVEKLGIKsqedpeleeatkevyrAEF 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 370 YTGV-GEHInsGELNGLDNEAAISKAIELLVAKGAG-------EKKV-------------------NYK----------- 411
Cdd:PRK12300 338 HKGVlKENT--GEYAGKPVREAREKITKDLIEKGIAdimyefsNRPVycrcgtecvvkvvkdqwfiDYSdpewkelahka 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 412 ---------------------LRDWLFSRQRYWGEPIPvihWEDG------SMTTV-----------------PEDelpl 447
Cdd:PRK12300 416 ldnmeiipeeyrkefentidwLKDRACARRRGLGTRLP---WDEEwiieslSDSTIymayytiahkireygikPEQ---- 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 448 LLPET-DEIKpSGTGesplaNIDEfvnvVDEKTGmkgrretntmpqwagscwyylryIDPNNSKMLAdpEKLKHWLPVDL 526
Cdd:PRK12300 489 LTPEFfDYVF-LGKG-----DPEE----VSKKTG-----------------------IPKEILEEMR--EEFLYWYPVDW 533
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 527 YIGGVEHAVLHLLYARFWHKVLFDlgvvPTKEPFQKLYNqGMILGEGnEKMSKSKGNVVNPDDIVNSHGADTLRLYEMFM 606
Cdd:PRK12300 534 RHSGKDLIPNHLTFFIFNHVAIFP----EEKWPRGIVVN-GFVLLEG-KKMSKSKGNVIPLRKAIEEYGADVVRLYLTSS 607
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 607 GPLDAAIAWSENGLDGSRRFLDRvWRLFINEdgsLTDKVVENNDTKLDK----VFNQTVKKVTEDFNSLNFNTAIS---- 678
Cdd:PRK12300 608 AELLQDADWREKEVESVRRQLER-FYELAKE---LIEIGGEEELRFIDKwllsRLNRIIKETTEAMESFQTRDAVQeafy 683
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 679 QLMVFINEcYKS------ETIYKPYAEGFIKMLAPIAPHIGEELWNRLGNDDTITYQPWPTYDESLL---VDAEVEIVVQ 749
Cdd:PRK12300 684 ELLNDLRW-YLRrvgeanNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPDESKIdeeAELAEEYVKR 762
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 920628917 750 VNGKVRAKMNI----PK-------DTSKDEMEALALQDENVKLSIE-----------GKDIKKVIavpQKLVNIVAK 804
Cdd:PRK12300 763 LIEDIREILKVakikPKkvyiyvaPDWKYEVLEIAAENGDVKEAIKelmkdeelrkhGKEVAKLA---QKIVKEVLK 836
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
1-745 |
1.73e-51 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 194.53 E-value: 1.73e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 1 MGYNHKEIEKKWQNYWTDNKTFKTS--DNLGQKKFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGW 78
Cdd:COG0060 14 MRANLPKREPEILKFWEENDIYEKSreARAGRPKFVLHDGPPYANGD-IHIGHALNKILKDIIVRYKTMRGFDVPYVPGW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 79 DAFGLPAE-----QYALdTGNDP------------REFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYK--WtqWIF 139
Cdd:COG0060 93 DCHGLPIElkvekELGI-KKKDIekvgiaefrekcREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEEsiW--WAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 140 IQLYNKGLAYVDEVAVNWCPALGTVLSNEEVvdgvsergghpvyrrpmkqwvlkitEYADRllEDLdeldwpeSIkdmqr 219
Cdd:COG0060 170 KKLYEKGLLYKGLKPVPWCPRCGTALAEAEV-------------------------EYKDV--TSP-------SI----- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 220 nwigrsegaSVSFKVDNS-------DESIDVFTTRPDTIYGTTFLVLSPEH--ALVnKITSADKL----ETVKQYQEEAs 286
Cdd:COG0060 211 ---------YVKFPVKDEkalllleDAYLVIWTTTPWTLPANLAVAVHPDIdyVLV-EVTGGERLilaeALVEAVLKEL- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 287 KKSDLERTdlakdksGVFTGA-----YAINPLSGETL-----PIWIADYVLSSYGTGAV-MAvPAHDERDYEFASKFNLP 355
Cdd:COG0060 280 GIEDYEVL-------ATFKGAeleglRYEHPFYYVVGydrahPVILGDYVTTEDGTGIVhTA-PGHGEDDFEVGKKYGLP 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 356 I-NEVIAGGdiqkeAYTG-----VGEHInsgelngLDNEAAIskaIELLVAKGA----GE-------------------- 405
Cdd:COG0060 352 VlNPVDDDG-----RFTEeaplfAGLFV-------KDANPAI---IEDLKERGAllarEKithsyphcwrcktpliyrat 416
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 406 ------------------KKVNYK--------------LRDWLFSRQRYWGEPIPVihWEDgsmttvPEDELPLLLPET- 452
Cdd:COG0060 417 pqwfismdklrdraleaiEKVNWIpewgegrfgnmlenRPDWCISRQRYWGVPIPI--WVC------EDCGELHRTEEVi 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 453 ----DEIKPSGTG-------ESPLanIDEFVNVVDEKTGMkgRRETNTMPQW--AGSCWYYlryidpnnskMLADPEKLk 519
Cdd:COG0060 489 gsvaELLEEEGADawfeldlHRPF--LDETLKCPKCGGTM--RRVPDVLDVWfdSGSMHFA----------VLENREEL- 553
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 520 HWlPVDLYIGGV-EHavlhllyaRFW----HKV---LFDlgvvptKEPFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIV 591
Cdd:COG0060 554 HF-PADFYLEGSdQT--------RGWfyssLLTstaLFG------RAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVI 618
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 592 NSHGADTLRLYeMFMGPLDAAIAWSENGLDGSRRFLDRVW---RLFInedGSL------TDKVVENNDTKLDK----VFN 658
Cdd:COG0060 619 DKYGADILRLW-VASSDYWGDLRFSDEILKEVRDVYRRLRntyRFLL---ANLddfdpaEDAVPYEDLPELDRwilsRLN 694
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 659 QTVKKVTEDFNSLNFNTAISQLMVFINE---------------CYKSETIYKPYA--------EGFIKMLAPIAPHIGEE 715
Cdd:COG0060 695 ELIKEVTEAYDNYDFHRAYRALHNFCVEdlsnwyldiskdrlyTEAADSLDRRAAqttlyevlETLVRLLAPILPFTAEE 774
|
890 900 910
....*....|....*....|....*....|..
gi 920628917 716 LWNRL--GNDDTITYQPWPTYDESlLVDAEVE 745
Cdd:COG0060 775 IWQNLpgEAEESVHLADWPEVDEE-LIDEELE 805
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
40-601 |
7.79e-50 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 180.14 E-value: 7.79e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 40 PYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPA----EQYALDTG----NDPRE--------FTQQN 103
Cdd:cd00817 10 PNVTGS-LHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATqvvvEKKLGIEGktrhDLGREeflekcweWKEES 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 104 IQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEvvdgVSERGGHPVY 183
Cdd:cd00817 89 GGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIE----VCSRSGDVIE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 184 RRPMKQWVLKITEYADRLLEDLDE--LDW-PESIKDMQRNWIGrsegasvsfkvdnsdesidvfttrpdtiygttflvls 260
Cdd:cd00817 165 PLLKPQWFVKVKDLAKKALEAVKEgdIKFvPERMEKRYENWLE------------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 261 pehalvnkitsadkletvkqyqeeaskksdlertdlakdksgvftgayainplsgetlpiwiadyvlssygtgavmavpa 340
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 341 hderdyefaskfnlpineviaggdiqkeaytgvgehinsgelngldneaaiskaiellvakgagekkvnyKLRDWLFSRQ 420
Cdd:cd00817 208 ----------------------------------------------------------------------NIRDWCISRQ 217
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 421 RYWGEPIPVIHWEDGSMTTVPEDELPLLLPETDEIKPSGTGESPlanidefvnvvdektgmkgRRETNTMPQWAGScWYY 500
Cdd:cd00817 218 LWWGHRIPAWYCKDGGHWVVAREEDEAIDKAAPEACVPCGGEEL-------------------KQDEDVLDTWFSS-SLW 277
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 501 LRYIdpnnSKMLADPEKLKHWLPVDLYIGGveHAVLhllyaRFWHKVLFDLGVVPTKE-PFQKLYNQGMILGEGNEKMSK 579
Cdd:cd00817 278 PFST----LGWPEETKDLKKFYPTSLLVTG--HDII-----FFWVARMIMRGLKLTGKlPFKEVYLHGLVRDEDGRKMSK 346
|
570 580
....*....|....*....|..
gi 920628917 580 SKGNVVNPDDIVNSHGADTLRL 601
Cdd:cd00817 347 SLGNVIDPLDVIDGYGADALRF 368
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
2-761 |
2.18e-46 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 179.42 E-value: 2.18e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 2 GYNHKEIEKKWQNYWTDNKTFKTSDNLGQKKFYALdMFPYPSGAG-LHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDA 80
Cdd:PRK14900 18 GYEHREVEARWYPFWQERGYFHGDEHDRTRPPFSI-VLPPPNVTGsLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDH 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 81 FGLpAEQYAL-------------DTGndpREFTQQNIQTFK--------RQIQELGFSYDWDREVNTTDPEYYKWTQWIF 139
Cdd:PRK14900 97 AGI-ATQMIVekelkktekksrhDLG---REAFLERVWAWKeqygsrigEQHKALGASLDWQRERFTMDEGLSRAVREVF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 140 IQLYNKGLAYVDEVAVNWCPALGTVLSNEEVVDGVSERGghpvyrrpmkqwvlkiteyadrlledldELdwpesikdmqr 219
Cdd:PRK14900 173 VRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQG----------------------------EL----------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 220 nWigrsegaSVSFKVDNSDESIDVFTTRPDTIYGTTFLVLSPEHalvnkitsadkletvKQYQEEASKKsdlertdlakd 299
Cdd:PRK14900 214 -W-------SFAYPLADGSGEIVVATTRPETMLGDTAVAVHPLD---------------PRYMALHGKK----------- 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 300 ksgvftgayAINPLSGETLPIwIADYVL--SSYGTGAVMAVPAHDERDYEFASKFNLPINEVIA-GGDIQKEAytgvgeh 376
Cdd:PRK14900 260 ---------VRHPITGRTFPI-VADAILvdPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGpDGRMTAEA------- 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 377 insGELNGLDNEAAISKAIELLVAKGAGEKKVNYKL-------------------------------------------- 412
Cdd:PRK14900 323 ---GPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLplgrcqrsatilepllsdqwyvrieplarpaieaveqgrtrfip 399
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 413 --------------RDWLFSRQRYWGEPIPVIHWEDGSMTTVPEdelplllpetdeiKPSGTgesPLANIDEFvnvvdek 478
Cdd:PRK14900 400 eqwtntymawmrniHDWCISRQLWWGHQIPAWYCPDGHVTVARE-------------TPEAC---STCGKAEL------- 456
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 479 tgmkgRRETNTMPQWAGSC-WYYLRYIDPNNSkmladpEKLKHWLPVDLYIGGveHAVLHLLYARFWHKVLFDLGVVPtk 557
Cdd:PRK14900 457 -----RQDEDVLDTWFSSGlWPFSTMGWPEQT------DTLRTFYPTSVMETG--HDIIFFWVARMMMMGLHFMGEVP-- 521
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 558 epFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRLYEMFMGPLDAAIAWSENGLDGSRRFLDRVWR----L 633
Cdd:PRK14900 522 --FRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNasrfA 599
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 634 FINEDGSLTDKV--VENNDTKLDK-VFNQTVKKVTEDFNSLN---FNTAISQLMVFI--NEC-----YKSETIYKPYAEG 700
Cdd:PRK14900 600 LMNLSGYQERGEdpARLARTPADRwILARLQRAVNETVEALEafrFNDAANAVYAFVwhELCdwyieLAKEALASEDPEA 679
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 701 --------------FIKMLAPIAPHIGEELWNRL-------GNDDTITYQPWPTYDEsllVDAEVE-----IVVQVNG-- 752
Cdd:PRK14900 680 rrsvqavlvhclqtSYRLLHPFMPFITEELWHVLraqvgasAWADSVLAAEYPRKGE---ADEAAEaafrpVLGIIDAvr 756
|
....*....
gi 920628917 753 KVRAKMNIP 761
Cdd:PRK14900 757 NIRGEMGIP 765
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
3-767 |
1.47e-42 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 167.49 E-value: 1.47e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 3 YNHKEIEKKWQNYWTDNKTFKTSD---NLGQKKFYALdMFPYPSGAG-LHVGHPEGYTATDIVSRYKRMQGYNVLHPMGW 78
Cdd:PTZ00419 28 YDPKEVESGWYEWWEKSGFFKPAEdakSLNSGKKFVI-VLPPPNVTGyLHIGHALTGAIQDSLIRYHRMKGDETLWVPGT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 79 DAFGLPA----EQYALDTGNDPR-------------EFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQ 141
Cdd:PTZ00419 107 DHAGIATqvvvEKKLMKEENKTRhdlgreeflkkvwEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEAFVR 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 142 LYNKGLAYVDEVAVNWCPALGTVLSNEEVVdgvserggHPVYRRPMKqwvLKITEYaDRLLEdldeldwpesikdMQRNW 221
Cdd:PTZ00419 187 LYEDGLIYRDTRLVNWCCYLKTAISDIEVE--------FEEIEKPTK---ITIPGY-DKKVE-------------VGVLW 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 222 IgrsegasVSFKVDNSDES-IDVFTTRPDTIYGTTFLVLSPEHalvnkitsadkletvKQYQEeaskksdlertdlakdk 300
Cdd:PTZ00419 242 H-------FAYPLEDSGQEeIVVATTRIETMLGDVAVAVHPKD---------------ERYKK----------------- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 301 sgvFTGAYAINP-LSGETLPIwIAD--YVLSSYGTGAVMAVPAHDERDYEFASKFNLP-INEVIAGGDIQKeaytgvgeh 376
Cdd:PTZ00419 283 ---LHGKELIHPfIPDRKIPI-IADdeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPfINIFTLDGKINE--------- 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 377 iNSGELNGLDNEAAISKAIELLVAKGAGEKKVNYKLR------------------------------------------- 413
Cdd:PTZ00419 350 -NGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRlprcsrsgdivepmlipqwyvnckdmakraveavrngelkiip 428
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 414 ---------------DWLFSRQRYWGEPIPVIHwedgsmTTVPedelplllpetdEIKPSGTGESPL---ANIDEFVNVV 475
Cdd:PTZ00419 429 sshenvwyhwleniqDWCISRQLWWGHRIPAYR------VISK------------GPETDPSDEEPWvvaRSEEEALEKA 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 476 DEKTGMKG-----RRETNTMPQWAGSC--------WyylryidPNNSkmladpEKLKHWLPVDLYIGGveHAVLHLLYAR 542
Cdd:PTZ00419 491 KKKFGLSEedfelEQDEDVLDTWFSSGlfpfstlgW-------PDQT------DDLQRFFPTSLLETG--SDILFFWVAR 555
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 543 FwhkVLFDLGVVpTKEPFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTL--RLYEmfmGPLD---------- 610
Cdd:PTZ00419 556 M---VMMSLHLT-DKLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLnqKLYE---GNLPekeikraiel 628
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 611 -------------------AAIAWSENG----LD-----GSRRFLDRVW---RLFI-------NEDGSLTDKVVENNDTK 652
Cdd:PTZ00419 629 qkkefpngipecgtdalrfGLLAYTQQGrninLDinrvvGYRHFCNKLWnavKFALmkllkdfNLPNSTLFKPNNVESLP 708
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 653 L-DK----VFNQTVKKVTEDFNSLNFNTAISQLM---------VFInECYK---------------SETIYKPYAEGfIK 703
Cdd:PTZ00419 709 WeDKwilhRLNVAIKEVTEGFKEYDFSEATQATYnfwlyelcdVYL-ELIKprlskqsdgerkqhaQDVLHTVLDIG-LR 786
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 920628917 704 MLAPIAPHIGEELWNRLGND----DTITYQPWPTY-----DESllVDAEVEIVVQVNGKVR---AKMNIPKDTSKD 767
Cdd:PTZ00419 787 LLHPMMPFITEELYQRLPNYlrksESISIAKYPQPnpgwnNEA--LDEEMKIIMSIVKSIRsliATLGIPNKTKPD 860
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
615-720 |
2.81e-41 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 146.60 E-value: 2.81e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 615 WSENGLDGSRRFLDRVWRLFINEDGSLTDKVVENNDTK----LDKVFNQTVKKVTEDFNSLNFNTAISQLMVFINECYKS 690
Cdd:cd07958 1 WSDSGVEGAYRFLNRVWRLVTELAEALAAPAAAAELSEedkeLRRKLHKTIKKVTEDIERLRFNTAIAALMELVNALYKY 80
|
90 100 110
....*....|....*....|....*....|....*..
gi 920628917 691 ET-------IYKPYAEGFIKMLAPIAPHIGEELWNRL 720
Cdd:cd07958 81 KKkdaqhaaVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
32-222 |
1.18e-37 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 143.33 E-value: 1.18e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 32 KFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYA-------------LDTGNDPRE 98
Cdd:cd00668 1 KFYVTTPPPYANGS-LHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 99 FTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYvdevavnwcpalgtvlsneevvdgvseRG 178
Cdd:cd00668 80 FVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIY---------------------------RG 132
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 920628917 179 GHPVyrRPMKQWVLKITEYADRLLEDLDELDW-PESIKDMQRNWI 222
Cdd:cd00668 133 THPV--RITEQWFFDMPKFKEKLLKALRRGKIvPEHVKNRMEAWL 175
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
9-746 |
8.87e-37 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 149.15 E-value: 8.87e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 9 EKKWQNYWTDNKTFKT-SDNLGQKKFYALDMFPYPSGaGLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQ 87
Cdd:PLN02843 9 EPEIQKLWEENQVYKRvSDRNNGESFTLHDGPPYANG-DLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIEL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 88 YALDTGND--------------PREFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEV 153
Cdd:PLN02843 88 KVLQSLDQearkeltpiklrakAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 154 AVNWCPALGTVLSNEEVvdGVSErgGH---PVYRrpmkqwVLKITEYADRLLEDLDELdwpesIKDMqrnwigrsegasv 230
Cdd:PLN02843 168 PVHWSPSSRTALAEAEL--EYPE--GHvskSIYV------AFPVVSPSETSPEELEEF-----LPGL------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 231 sfkvdnsdeSIDVFTTRPDTIYGTTFLVLSP--EHALVNKITSADKLETVKQYQEEASKKSDLER--------TDLAK-- 298
Cdd:PLN02843 220 ---------SLAIWTTTPWTMPANAAVAVNDklQYSVVEVQSFSEDESTSGGNKKKRPGNVLKEQqklflivaTDLVPal 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 299 -DKSGV-------FTGA------YaINPLSGETLPIWIA-DYVLSSYGTGAVMAVPAHDERDYEFASKFNLPI-NEVIAG 362
Cdd:PLN02843 291 eAKWGVklvvlktFPGSdlegcrY-IHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLlSPVDDA 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 363 GDIQKEAytgvgehinsGELNGLD-----NEAAISKAIE--LLVAKGAGEKKVNYKLR---------------------- 413
Cdd:PLN02843 370 GKFTEEA----------GQFSGLSvlgegNAAVVEALDEagSLLMEEAYGHKYPYDWRtkkptifrateqwfasvegfrq 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 414 ----------------------------DWLFSRQRYWGEPIPVIHwedgsmtTVPEDElPLLLPETdeikpsgtgespL 465
Cdd:PLN02843 440 aaldaidkvkwipaqgenriramvsgrsDWCISRQRTWGVPIPVFY-------HVETKE-PLMNEET------------I 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 466 ANIDEFV-----------NVVD---EKTGMKG---RRETNTMPQW--AGSCWyylryidpnnSKMLADPEKLKHwlPVDL 526
Cdd:PLN02843 500 AHVKSIVaqkgsdawwymDVEDllpEKYRDKAsdyEKGTDTMDVWfdSGSSW----------AGVLGSREGLSY--PADL 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 527 YIGGVEHavlHllyaRFWHKVLFDLGVVPT-KEPFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIV----NS-----HGA 596
Cdd:PLN02843 568 YLEGSDQ---H----RGWFQSSLLTSVATKgKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIeggkNQkqepaYGA 640
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 597 DTLRLY--------EMFMGP-LDAAIAWSENGLDGSRRFL---------------------DRvWRLFinedgsLTDKVV 646
Cdd:PLN02843 641 DVLRLWvasvdytgDVLIGPqILKQMSDIYRKLRGTLRYLlgnlhdwkpdnavpyedlpsiDK-YALF------QLENVV 713
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 647 ENNDTKLD-----KVFNQTVKKVTEDFNSLNFNTAISQLMVFINECYK---SETIYKPYAEGFIKMLAPIAPHIGEELWN 718
Cdd:PLN02843 714 NEIEESYDnyqffKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTrrsCQTVLAAHLLSLLRAIAPILPHLAEDAWQ 793
|
890 900 910
....*....|....*....|....*....|....
gi 920628917 719 RL------GNDDTITYQPWPTYDESLLVDAEVEI 746
Cdd:PLN02843 794 NLpfqedgSAAESVFEAGWPTPNEEWLSFPAEDV 827
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
9-733 |
2.50e-33 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 138.15 E-value: 2.50e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 9 EKKWQNYWTDNKTFKTSDNLGQKKFyALDMFPYPSGAGLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLpAEQY 88
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPF-VIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGI-ATQL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 89 AL------------DTGNDprEFTQQNIQ-------TFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAY 149
Cdd:PLN02943 144 VVekmlasegikrtDLGRD--EFTKRVWEwkekyggTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIY 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 150 VDEVAVNWCPALGTVLSNEEVvdgvsergghpvyrrpmkqwvlkitEYADRlledldeldwPESIKDMQRNWIGrsegas 229
Cdd:PLN02943 222 QGSYMVNWSPNLQTAVSDLEV-------------------------EYSEE----------PGTLYYIKYRVAG------ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 230 vsfkvdNSDESIDVFTTRPDTIYGTTFLVLSPEHalvnkitsadkletvKQYQEeaskksdlertdlakdksgvFTGAYA 309
Cdd:PLN02943 261 ------GSEDFLTIATTRPETLFGDVAIAVNPED---------------DRYSK--------------------YIGKMA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 310 INPLS-GETLPIwIAD-YVLSSYGTGAVMAVPAHDERDYEFASKFNLPI----------NEVIA---------------- 361
Cdd:PLN02943 300 IVPMTyGRHVPI-IADrYVDKDFGTGVLKISPGHDHNDYLLARKLGLPIlnvmnkdgtlNEVAGlywfeareklwsdlee 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 362 -GGDIQKEAYT-GVGEHINSGE-------------LNGLDNEA--AISKAiELLVAKGAGEKKVNYKL---RDWLFSRQR 421
Cdd:PLN02943 379 tGLAVKKEPHTlRVPRSQRGGEvieplvskqwfvtMEPLAEKAlkAVENG-ELTIIPERFEKIYNHWLsniKDWCISRQL 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 422 YWGEPIPVihWedgsmTTVPEDelplllPETDEIKPSgtgesplaNIDEFVNVVDEKTG--MKGRRETNTMPQW-AGSCW 498
Cdd:PLN02943 458 WWGHRIPV--W-----YIVGKD------CEEDYIVAR--------SAEEALEKAREKYGkdVEIYQDPDVLDTWfSSALW 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 499 YYLRYIDPNNSKmladpEKLKHWLPVDLYIGGveHAVLHllyarFWHKVLFDLGVVPT-KEPFQKLYNQGMILGEGNEKM 577
Cdd:PLN02943 517 PFSTLGWPDVSA-----EDFKKFYPTTVLETG--HDILF-----FWVARMVMMGIEFTgTVPFSYVYLHGLIRDSQGRKM 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 578 SKSKGNVVNPDDIVNSHGADTLRlYEMFMGPLDAAIAWSENGLDGSRRFLDRVW---RLFINEDGSLTDKVVENN--DTK 652
Cdd:PLN02943 585 SKTLGNVIDPLDTIKEFGTDALR-FTLALGTAGQDLNLSTERLTSNKAFTNKLWnagKFVLQNLPSQSDTSAWEHilACK 663
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 653 LDK----------------VFNQTVKKVTEDFNSLNFNTAISQLMVFI-------------NECYKSETIYKPYA----- 698
Cdd:PLN02943 664 FDKeesllslplpecwvvsKLHELIDSVTTSYDKYFFGDVGREIYDFFwsdfadwyieaskTRLYHSGDNSALSRaqavl 743
|
810 820 830 840
....*....|....*....|....*....|....*....|
gi 920628917 699 ----EGFIKMLAPIAPHIGEELWNRLGND-DTITYQPWPT 733
Cdd:PLN02943 744 lyvfENILKLLHPFMPFVTEELWQALPYRkEALIVSPWPQ 783
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
3-803 |
8.17e-28 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 120.77 E-value: 8.17e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 3 YNHKEIEKKWQNYWTDNKTFKTSDNLGQKKFYALdmFPYPSGAG-LHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAF 81
Cdd:PLN02381 100 YSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIV--LPPPNVTGaLHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHA 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 82 GLPAEQYALDTGNDPREFTQQNIQ-----------------TFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYN 144
Cdd:PLN02381 178 GIATQVVVEKKLMRERHLTRHDIGreefvsevwkwkdeyggTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYK 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 145 KGLAYVDEVAVNWCPALGTVLSNEEV--VDgVSERG--GHPVYRRPMKQWVLkiTEYADRLLEDLDEldwpesikdmqrn 220
Cdd:PLN02381 258 EGLIYRDIRLVNWDCTLRTAISDVEVdyID-IKERTllKVPGYDKPVEFGVL--TSFAYPLEGGLGE------------- 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 221 wigrsegasvsfkvdnsdesIDVFTTRPDTIYGTTFLVLSPEHAlvnkitsadkletvkQYQEeaskksdlertdlakdk 300
Cdd:PLN02381 322 --------------------IVVATTRIETMLGDTAIAIHPDDE---------------RYKH----------------- 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 301 sgvFTGAYAINPLSGETLPIwIADYVL--SSYGTGAVMAVPAHDERDYEFASKFNLP-INEVIAGGDIQK---------- 367
Cdd:PLN02381 350 ---LHGKFAVHPFNGRKLPI-ICDAILvdPNFGTGAVKITPAHDPNDFEVGKRHNLEfINIFTDDGKINSnggsefagmp 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 368 --EAYTGVGEHINSGEL--NGLDNEAAI-----------------------SKAIELLVAKGAGE-KKVNY--------- 410
Cdd:PLN02381 426 rfAAREAVIEALQKKGLyrGAKNNEMRLglcsrtndvvepmikpqwfvncsSMAKQALDAAIDGEnKKLEFipkqylaew 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 411 -----KLRDWLFSRQRYWGEPIPVihWedgsMTTVPEDELPLLLPETDEIKPSGTGESPLANIDEfvnvvdEKTGMKGR- 484
Cdd:PLN02381 506 krwleNIRDWCISRQLWWGHRIPA--W----YVTLEDDQLKELGSYNDHWVVARNESDALLEASQ------KFPGKKFEl 573
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 485 -RETNTMPQWAGSCWYYLRYID-PNnskmlaDPEKLKHWLPVDLYIGGveHAVLHllyarFWHKVLFDLGVVPTKE-PFQ 561
Cdd:PLN02381 574 sQDPDVLDTWFSSGLFPLSVLGwPD------DTDDLKAFYPTSVLETG--HDILF-----FWVARMVMMGMQLGGDvPFR 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 562 KLYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTL--RLYEMFMGPLDAAIA-----------WSENGLD------- 621
Cdd:PLN02381 641 KVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLhkRLEEGNLDPKELVVAkegqkkdfpngIAECGTDalrfalv 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 622 -----------------GSRRFLDRVWRLFINEDGSLTDKVVENNDTKLD----------KVFNQTVKKVTEDFNSLNFN 674
Cdd:PLN02381 721 sytaqsdkinldilrvvGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVEtmpfsckwilSVLNKAISKTVSSLDAYEFS 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 675 TAISQLM---------VFInecyksETIyKPYAEG----------------------FIKMLAPIAPHIGEELWNRL--- 720
Cdd:PLN02381 801 DAASTVYswwqyqfcdVFI------EAI-KPYFAGdnpefaseraaaqdtlwicldtGLRLLHPFMPFVTEELWQRLpqp 873
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 721 ---GNDDTITYQPWPTYDESLL---VDAEVEIVVQVNGKVRA-KMNIPKDTSKDEMEALALqdenvklsIEGKDIKKVIA 793
Cdd:PLN02381 874 kdhTRKDSIMISEYPSAVEAWTnekVEYEMDLVLSTVKCLRSlRAEVLEKQKNERLPAFAL--------CRNQEIAAIIK 945
|
970
....*....|
gi 920628917 794 VPQKLVNIVA 803
Cdd:PLN02381 946 SHQLEILTLA 955
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
40-222 |
2.07e-27 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 113.78 E-value: 2.07e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 40 PYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQNIQTFKRQIQELGFSYD 119
Cdd:cd00814 9 PYVNGV-PHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFKWLNISFD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 120 -WDRevnTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLsneevvdgvsergghPVYRRPmKQWVLKITEYA 198
Cdd:cd00814 88 yFIR---TTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFL---------------PEWREE-EHYFFRLSKFQ 148
|
170 180
....*....|....*....|....*..
gi 920628917 199 DRLLEDLDE---LDWPESIKDMQRNWI 222
Cdd:cd00814 149 DRLLEWLEKnpdFIWPENARNEVLSWL 175
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
31-602 |
1.04e-25 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 109.24 E-value: 1.04e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 31 KKFYALDMFPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDP-------------- 96
Cdd:cd00818 1 PEFVFHDGPPYANGL-PHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISgkkdiekmgiaefn 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 97 ---REFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWcpalgtvlsneevvdg 173
Cdd:cd00818 80 akcREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW---------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 174 vsergghPVYRRPMKQWVLKITEYADRLLEDLDELDW-PESIKDMQRNWIGRsegasvsfkvdnsdesidvfttrpdtiy 252
Cdd:cd00818 144 -------PLIYRATPQWFIRVTKIKDRLLEANDKVNWiPEWVKNRFGNWLEN---------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 253 gttflvlspehalvnkitsadkletvkqyqeeaskksdlertdlakdksgvftgayainplsgetlpiwiadyvlssygt 332
Cdd:cd00818 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 333 gavmavpahderdyefaskfnlpineviaggdiqkeaytgvgehinsgelngldneaaiskaiellvakgagekkvnykL 412
Cdd:cd00818 189 -------------------------------------------------------------------------------R 189
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 413 RDWLFSRQRYWGEPIPVihWedgsmttVPEDELPLLLpetdeikpsgtgesplanidefvnvvdektgmkgRRETNTMPQ 492
Cdd:cd00818 190 RDWCISRQRYWGTPIPV--W-------YCEDCGEVLV----------------------------------RRVPDVLDV 226
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 493 W--AGSCWYYLRYIDPNNskmladpEKLKHWLPVDLYIGGVEHA-----VLHLLYArfwhkVLFDlgvvptKEPFQKLYN 565
Cdd:cd00818 227 WfdSGSMPYAQLHYPFEN-------EDFEELFPADFILEGSDQTrgwfySLLLLST-----ALFG------KAPYKNVIV 288
|
570 580 590
....*....|....*....|....*....|....*..
gi 920628917 566 QGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRLY 602
Cdd:cd00818 289 HGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLW 325
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
31-222 |
1.07e-25 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 112.13 E-value: 1.07e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 31 KKFY---ALdmfPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQNIQTF 107
Cdd:COG0143 1 KKFLvttAI---PYANGP-PHIGHLYTYIPADILARYQRLRGHDVLFVTGTDEHGTKIELAAEKEGITPQELVDRIHAEF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 108 KRQIQELGFSYD-WDRevnTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCP--------------------------- 159
Cdd:COG0143 77 KELFEKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEYEGWYCPecerflpdryvegtcpkcgaedaygdq 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 920628917 160 --ALGTVLSNEEVVDGVSERGGHPVYRRPMKQWVLKITEYADRLLEDLDEL-DWPESIKDMQRNWI 222
Cdd:COG0143 154 ceNCGATLEPTELINPRSAISGAPPELREEEHYFFRLSKYQDRLLEWIEENpDIQPEVRNEVLSWL 219
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
39-222 |
4.96e-23 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 101.98 E-value: 4.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 39 FPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQNIQTFKRQIQELGFSY 118
Cdd:pfam09334 7 LPYANGP-PHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKKFNISF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 119 D-WDRevnTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPA-----------------------------LGTVLSNE 168
Cdd:pfam09334 86 DdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSderflpdryvegtcphcgsedargdqcenCGRHLEPT 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 920628917 169 EVVDGVSERGGHPVYRRPMKQWVLKITEYADRLLE--DLDELDWPESIKDMQRNWI 222
Cdd:pfam09334 163 ELINPKCVICGTTPEVKETEHYFFDLSKFQDKLREwiEENNPEWPENVKNMVLEWL 218
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
31-203 |
1.47e-22 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 102.27 E-value: 1.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 31 KKFY---ALdmfPYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQNIQTF 107
Cdd:PRK11893 1 KKFYittPI---YYPNGK-PHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 108 KRQIQELGFSYdwDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVVDG--VSERGGHPVYRR 185
Cdd:PRK11893 77 KRLWEALNISY--DDFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEGWYCVRCEEFYTESELIEDgyRCPPTGAPVEWV 154
|
170
....*....|....*...
gi 920628917 186 PMKQWVLKITEYADRLLE 203
Cdd:PRK11893 155 EEESYFFRLSKYQDKLLE 172
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
650-767 |
2.65e-22 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 93.62 E-value: 2.65e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 650 DTKLDKVFNQTVKKVTEDFNSLNFNTAISQLMVFINECYKS--------------------ETIYKpYAEGFIKMLAPIA 709
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDwylelikdrlygeepdsraqTTLYE-VLETLLRLLAPFM 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 920628917 710 PHIGEELWNRlgndDTITYQPWPTYDESLLVDAEVEI-----VVQVNGKVRAKMNIPKDTSKD 767
Cdd:pfam08264 80 PFITEELWQK----ESIHLAPWPEDAELEEAELEEAFelrqeIVQAIRKLRSELKIKKSLPLE 138
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
2-786 |
4.99e-20 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 95.95 E-value: 4.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 2 GYNHKEIEKKWQNYWTDNKTFKT----SDNLGQKKFYalDMFPYPSGAGlHVGHPEGYTATDIVSRYKRMQGYNVLHPMG 77
Cdd:PLN02882 7 DFSFPKQEEKILSLWSEIDAFKTqlkrTEGLPEYIFY--DGPPFATGLP-HYGHILAGTIKDIVTRYQSMTGHHVTRRFG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 78 WDAFGLPAEqYALD-----TGNDP-------------REFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIF 139
Cdd:PLN02882 84 WDCHGLPVE-YEIDkklgiKRRDDvlkmgidkyneecRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 140 IQLYNKGLAYVDEVAVNWCPALGTVLSNEEVVdgvsergghpvyrrpmkqwvlkiTEYADrlLEDldeldwPESIkdmqr 219
Cdd:PLN02882 163 KQLFEKGLVYKGFKVMPYSTACKTPLSNFEAG-----------------------LNYKD--VSD------PAVM----- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 220 nwigrsegasVSFKV--DNSDESIDVFTTRPDTIYGTTFLVLSPEHALV---NKITSA------DKLETVKQYQEEASKK 288
Cdd:PLN02882 207 ----------VSFPIvgDPDNASFVAWTTTPWTLPSNLALCVNPNFTYVkvrNKYTGKvyivaeSRLSALPTAKPKSKKG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 289 SDLERTD-----LAKDKSGVFTG-AYA-----INPLSGETLPIWIADYVLSSYGTGAVMAVPAHDERDYEFASKfnlpiN 357
Cdd:PLN02882 277 SKPENAAegyevLAKVPGSSLVGkKYEplfdyFSEFSDTAFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLA-----N 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 358 EVIAGGDIQKEAYTGVGEHINS-GELNGLDNEAAISKAIELLVAKG---------------------------------- 402
Cdd:PLN02882 352 GIIEKGGNLPVPVDDDGCFTEKvTDFSGRYVKDADKDIIAAIKAKGrlvksgsithsypfcwrsdtpliyravpswfvkv 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 403 --------------------AGEKKVNYKL---RDWLFSRQRYWGEPIPVIHWEDGSMTTV--PEDELPLLLPE------ 451
Cdd:PLN02882 432 eeikdrllennkqtywvpdyVKEKRFHNWLenaRDWAVSRSRFWGTPLPIWISDDGEEVVVigSIAELEKLSGVkvtdlh 511
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 452 ---TDEIK-PS--GTGESPLANIDEfvnVVDektgmkGRRETNTMPqwagscWYYLRYidPNNSKmladpEKLKHWLPVD 525
Cdd:PLN02882 512 rhfIDHITiPSsrGPEFGVLRRVDD---VFD------CWFESGSMP------YAYIHY--PFENK-----ELFEKNFPAD 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 526 LYIGGVEHavlhllyARFWhkvLFDLGVVPT----KEPFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRL 601
Cdd:PLN02882 570 FVAEGLDQ-------TRGW---FYTLMVLSTalfdKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRL 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 602 YeMFMGPLDAA--IAWSENGLDGS------------RRFLDRVWRL-------FINEDGSLTDKVVENNDTKLDKVFNQT 660
Cdd:PLN02882 640 Y-LINSPVVRAepLRFKEEGVFGVvkdvflpwynayRFLVQNAKRLeveggapFVPLDLAKLQNSANVLDRWINSATQSL 718
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 661 VKKVTEDFNSLNFNTAISQLMVFINECyksETIYKPYAEGFIK------------------------MLAPIAPHIGEEL 716
Cdd:PLN02882 719 VKFVREEMGAYRLYTVVPYLVKFIDNL---TNIYVRFNRKRLKgrtgeedcrtalstlynvlltsckVMAPFTPFFTEVL 795
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 717 WNRL-----GNDDTITYQPWPTYDESLLvDAEVE-------IVVQVNGKVRAKMNIPKDTSKDEMeALALQDENVKLSIE 784
Cdd:PLN02882 796 YQNLrkvlpGSEESIHYCSFPQVDEGEL-DERIEqsvsrmqTVIELARNIRERHNKPLKTPLKEM-VVVHPDAEFLDDIT 873
|
..
gi 920628917 785 GK 786
Cdd:PLN02882 874 GK 875
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
4-602 |
8.14e-17 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 85.40 E-value: 8.14e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 4 NHKEIEKKWQNYWTDNKTFKTSDNL--GQKKFYALDMFPYPSGAGlHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAF 81
Cdd:PTZ00427 73 NIVEEEEKVLKYWKSIDAFNTSNKLakNKKAYIFYDGPPFATGLP-HYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCH 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 82 GLPAE----------------QYALDTGNDP-REFTQQNIQTFKRQIQELGFSYDWDREVNTTDPEYYKWTQWIFIQLYN 144
Cdd:PTZ00427 152 GLPIEyeiekenninkkedilKMGIDVYNEKcRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 145 KGLAYVDEVAVNWCPALGTVLSNEEVVDGVSERGGHPVYRR-------PMKQWVLKITEYADRLLEDLDELdwpesIKDM 217
Cdd:PTZ00427 232 NNYVYKSFKVMPYSCKCNTPISNFELNLNYKDTPDPSIIISfvlcsdfPKVEEECNIEEDKQLLGEKYSVL-----YNNK 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 218 QRNWI--GRSEGASVSFKVDNsdeSIDVFTTRPDTI-------YGTTFLVLSPEHALVNK--ITSADKLE-TVKQYQEEA 285
Cdd:PTZ00427 307 RENSNngNNNSTNNVCYAQHS---EILAWTTTPWTLpsnlalcVNEHFTYLRIHHVKSNRvvIVGECRLEwIMKELKWNV 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 286 SKKSDLERTdLAKDKSG-----VFTGAYAINPLSGETLPIWIADYVLSSYGTGAVMAVPAHDERDYEFASKF-------N 353
Cdd:PTZ00427 384 EDLKIVNRF-KGKELKGlrykpLFTNFYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNgvidpekN 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 354 LPINEVIAGG-------DIQ----KEAYTGVGEHI-NSGELngLDNEAA--------------ISKAI------------ 395
Cdd:PTZ00427 463 IFIDPLDANGyftneveEVQnlyiKEADNVIKKKLkNENRL--LSNNTIvhsypfcwrsdtplIYRAIpawfirvsnstn 540
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 396 ELL--------VAKGAGEKKVNYKL---RDWLFSRQRYWGEPIPVihWEDGSMTTVPEDELPLLLPETDEIKpsgtgesp 464
Cdd:PTZ00427 541 ELVknnettywIPAHIKEKKFHNWIkdaKDWCISRNRYWGTPIPI--WADEKMETVICVESIKHLEELSGVK-------- 610
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 465 laNIDE----FVNVVDEKTGmKGRR--ETNTMPQwAGSCWY------YLRYIDPNNSkmlaDPEKLKHWLPVDLYIGGVE 532
Cdd:PTZ00427 611 --NINDlhrhFIDHIEIKNP-KGKTypKLKRIPE-VFDCWFesgsmpYAKVHYPFST----EKEDFHKIFPADFIAEGLD 682
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 920628917 533 HavlhllyARFWhkvLFDLGVVPT----KEPFQKLYNQGMILGEGNEKMSKSKGNVVNPDDIVNSHGADTLRLY 602
Cdd:PTZ00427 683 Q-------TRGW---FYTLLVISTllfdKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLY 746
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
41-203 |
5.22e-15 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 79.07 E-value: 5.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 41 YPSGAgLHVGHpeGYT--ATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQNIQTFKRQIQELGFSY 118
Cdd:PRK12267 14 YPNGK-PHIGH--AYTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFKELWKKLDISY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 119 dwDREVNTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEVVD-GVSERGGHPVYRRPMKQWVLKITEY 197
Cdd:PRK12267 91 --DKFIRTTDERHKKVVQKIFEKLYEQGDIYKGEYEGWYCVSCETFFTESQLVDgGKCPDCGREVELVKEESYFFRMSKY 168
|
....*.
gi 920628917 198 ADRLLE 203
Cdd:PRK12267 169 QDRLLE 174
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
514-727 |
1.31e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 74.45 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 514 DPEKLKHWLPVDLYIGGVE----HAVlhllyarFWHKVLFDLGVvptkEPFQKLYNQGMILGEGnEKMSKSKGNVVNPDD 589
Cdd:PRK12267 245 DDELFKKFWPADVHLVGKDilrfHAI-------YWPIMLMALGL----PLPKKVFAHGWWLMKD-GKMSKSKGNVVDPEE 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 590 IVNSHGADTLRLY---EM-FmgpldaaiawsenGLDGS---RRFLDRvwrlfINED-----GSL---------------- 641
Cdd:PRK12267 313 LVDRYGLDALRYYllrEVpF-------------GSDGDfspEALVER-----INSDlandlGNLlnrtvaminkyfdgei 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 642 -TDKVVENNDTKLDKVFNQTVKKVTEDFNSLNFNTAISQLMVFINECYKSETIYKPY-------------------AEGF 701
Cdd:PRK12267 375 pAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLISRANKYIDETAPWvlakdegkkerlatvmyhlAESL 454
|
250 260
....*....|....*....|....*....
gi 920628917 702 IK---MLAPIAPHIGEELWNRLGNDDTIT 727
Cdd:PRK12267 455 RKvavLLSPFMPETSKKIFEQLGLEEELT 483
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
40-222 |
1.34e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 74.42 E-value: 1.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 40 PYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFT----QQNIQTFKRqiqeLG 115
Cdd:PRK00133 11 PYANGP-IHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPEELIaryhAEHKRDFAG----FG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 116 FSYD-WDRevnTTDPEYYKWTQWIFIQLYNKGLAYVDEVAVNWCP-----------------------------ALGTVL 165
Cdd:PRK00133 86 ISFDnYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPekgmflpdrfvkgtcpkcgaedqygdnceVCGATY 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 920628917 166 SNEEVVDGVSER-GGHPVYRRPmKQWVLKITEYADRLLEDLD-ELDWPESIKDMQRNWI 222
Cdd:PRK00133 163 SPTELINPKSAIsGATPVLKES-EHFFFKLPRFEEFLKEWITrSGELQPNVANKMKEWL 220
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
615-720 |
5.13e-10 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 57.95 E-value: 5.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 615 WSENGLDGSRRFLDRVW---RL-FINEDGSLTDKVVENNDTKLDK----VFNQTVKKVTEDFNSLNFNTAISQLMVFI-- 684
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWnaaRFvLMNLEDDDEPEEDPESLSLADRwilsRLNKTVEEVTEALENYRFSEAATALYEFFwn 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 920628917 685 -----------------NECYKSETIYKPYA--EGFIKMLAPIAPHIGEELWNRL 720
Cdd:cd07962 81 dfcdwylelvkprlygeDEEEKKAARATLYYvlETILRLLHPFMPFITEELWQRL 135
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
567-686 |
5.14e-09 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 59.35 E-value: 5.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 567 GMILGEGnEKMSKSKGNVVNPDDIVNSHGADTLRLYeMFMG----PLDaaiaWSENGLDGSRRFLDRvWRLFINEdgslT 642
Cdd:COG0215 257 GFLTVNG-EKMSKSLGNFFTVRDLLKKYDPEVLRFF-LLSAhyrsPLD----FSEEALEEAEKALER-LYNALRR----L 325
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 920628917 643 DKVVENNDTKLDKvfnqtVKKVTEDF-NSLN--FNT--AISQLMVFINE 686
Cdd:COG0215 326 EEALGAADSSAEE-----IEELREEFiAAMDddFNTpeALAVLFELVRE 369
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
616-745 |
1.44e-07 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 52.17 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 616 SENGL-DGSRRFLDRVW---RLFIN-----EDGSLTDKVVENNDTKLDK----VFNQTVKKVTEDFNSLNFNTAISQLMV 682
Cdd:cd07961 2 SEKGVrEVVRKVLLPLWnayRFFVTyanldGFDPGKDDDAVASLNVLDRwilsRLNSLIKEVTEEMEAYDLYTAVRALLE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 683 FINE------------------------CYksETIYkpYA-EGFIKMLAPIAPHIGEELWNRLGND-----DTITYQPWP 732
Cdd:cd07961 82 FIDEltnwyirrnrkrfwgeegdddklaAY--ATLY--EVlLTLSRLMAPFTPFITEEIYQNLRRElgdapESVHLLDWP 157
|
170
....*....|...
gi 920628917 733 TYDESlLVDAEVE 745
Cdd:cd07961 158 EVDES-LIDEELE 169
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
7-84 |
3.28e-07 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 54.31 E-value: 3.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 7 EIEKKWQNYWTDNKTF-----KTSDNLGQKKFyalDMFPYPSGAG-LHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDA 80
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFeaeagDEPPKPGEKFF---GNFPYPYMNGlLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHC 93
|
....
gi 920628917 81 FGLP 84
Cdd:PLN02959 94 TGMP 97
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
615-720 |
4.43e-07 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 49.13 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 615 WSENGLDGSRRFLDRVWRLFinEDGSLTDKVVENNDTkLDKVF----NQTVKKVTEDFNSLNFNTAIsQLMVF------- 683
Cdd:cd07959 1 FREEEANSAILRLERFYELA--EELIETEGELEELTF-IDRWLlsrlNRLIKETTEAYENMQFREAL-KEGLYelqndld 76
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 920628917 684 -----INECYKSETIYKpYAEGFIKMLAPIAPHIGEELWNRL 720
Cdd:cd07959 77 wyrerGGAGMNKDLLRR-FIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
561-609 |
1.24e-06 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 50.99 E-value: 1.24e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 920628917 561 QKLYNQGMILGEGnEKMSKSKGNVVNPDDIVNSHGADTLRLYEMFMGPL 609
Cdd:cd00814 266 TRIVAHGYLTVEG-KKMSKSRGNVVDPDDLLERYGADALRYYLLRERPE 313
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
642-745 |
2.05e-05 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 45.98 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 642 TDKVVENNDTKLDKVF----NQTVKKVTEDFNSLNFNTAISQLMVFINE---------------CYKSE---------TI 693
Cdd:cd07960 34 KDAVPYEELLELDRYAlhrlNELIKEVREAYENYEFHKVYQALNNFCTVdlsafyldiikdrlyCDAKDslerrsaqtVL 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 920628917 694 YKpYAEGFIKMLAPIAPHIGEELWNRLG---NDDTITYQPWPTYDESLLVDAEVE 745
Cdd:cd07960 114 YH-ILDALLKLLAPILPFTAEEVWEHLPgekKEESVFLEDWPELPEEWKDEELEE 167
|
|
| PTZ00399 |
PTZ00399 |
cysteinyl-tRNA-synthetase; Provisional |
574-687 |
4.09e-05 |
|
cysteinyl-tRNA-synthetase; Provisional
Pssm-ID: 240402 [Multi-domain] Cd Length: 651 Bit Score: 46.95 E-value: 4.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 574 NEKMSKSKGNVVNPDDIVNSHGADTLRLyeMF-MGPLDAAIAWSENGLDGS-------RRFLDRVWRLFINEDGSLTDKv 645
Cdd:PTZ00399 313 GLKMSKSLKNFITIRQALSKYTARQIRL--LFlLHKWDKPMNYSDESMDEAiekdkvfFNFFANVKIKLRESELTSPQK- 389
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 920628917 646 VENNDTKLDKVFNQTVKKVTEDF-NSLNFNTAISQLMVFINEC 687
Cdd:PTZ00399 390 WTQHDFELNELFEETKSAVHAALlDNFDTPEALQALQKLISAT 432
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
59-170 |
3.39e-04 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 44.39 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 59 DIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQnIQTFKRQIqelgfsYDW-----DREVNTTDPEYYK 133
Cdd:PLN02610 45 DVFARYCRLRGYNAIYICGTDEYGTATETKALEENCTPKEICDK-YHAIHKEV------YDWfdisfDKFGRTSTPQQTE 117
|
90 100 110
....*....|....*....|....*....|....*..
gi 920628917 134 WTQWIFIQLYNKGLAYVDEVAVNWCPALGTVLSNEEV 170
Cdd:PLN02610 118 ICQAIFKKLMENNWLSENTMQQLYCDTCQKFLADRLV 154
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
556-602 |
7.53e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 41.80 E-value: 7.53e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 920628917 556 TKEPFQK--LYNqGMILGEGnEKMSKSKGNVVNPDDIVNSHGADTLRLY 602
Cdd:cd00672 154 TGKPFARywLHT-GHLTIDG-EKMSKSLGNFITVRDALKKYDPEVLRLA 200
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
617-689 |
1.01e-03 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 39.80 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 617 ENGLDGSRRFLDRVWRLFINEDGSLTDKVVENNDTKLDKV-------FNQTVKKVTEDFNSLNFNTAISQLMVFINECYK 689
Cdd:cd07375 1 EERLKQARAFLNRLYRLLSFFRKALGGTQPKWDNELLEEAdrellarLQEFIKRTTNALEALDPTTAVQELFKFTNELNW 80
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
41-149 |
1.31e-03 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 42.39 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 41 YPSGAGLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQNIQTFKRQIQELGFSYdw 120
Cdd:PLN02224 78 YYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGEKIATSAAANGRNPPEHCDIISQSYRTLWKDLDIAY-- 155
|
90 100
....*....|....*....|....*....
gi 920628917 121 DREVNTTDPEYYKWTQWIFIQLYNKGLAY 149
Cdd:PLN02224 156 DKFIRTTDPKHEAIVKEFYARVFANGDIY 184
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
40-121 |
3.61e-03 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 38.61 E-value: 3.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 920628917 40 PYPSGAgLHVGHPEGYTATDIVSRYKRMQGYNVLHPMGWDAFGLPAEQYALDTGNDPREFTQQNIQTFKRQiqelgfsYD 119
Cdd:cd00802 6 ITPNGY-LHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAGGLIGDPANKKGENAKAFVERWIERIKED-------VE 77
|
..
gi 920628917 120 WD 121
Cdd:cd00802 78 YM 79
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
526-592 |
6.25e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 40.13 E-value: 6.25e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 920628917 526 LYIGGVEHavlHLLYARFWhKVLFDLGVVPTKEPFQKLYnqGMILGEGNEKMSKSKGNVVNPDDIVN 592
Cdd:COG0018 335 IYVVGADQ---HGHFKRLF-AALKALGYDPAKDLEHLLF--GMVNLRDGEKMSTRAGTVVTLDDLLD 395
|
|
| |
