|
Name |
Accession |
Description |
Interval |
E-value |
| dacD |
PRK11397 |
serine-type D-Ala-D-Ala carboxypeptidase DacD; |
1-386 |
0e+00 |
|
serine-type D-Ala-D-Ala carboxypeptidase DacD;
Pssm-ID: 183117 [Multi-domain] Cd Length: 388 Bit Score: 824.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 1 MKGRFFIAVTLLASSVSCAFAANDFPVTVPPPSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSH 80
Cdd:PRK11397 1 LKRRLIIAASLFAFNLSSAFAAENIPFSPQPPAIDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 81 RISFDDMVTVGRDAWAKGNPVFDGSSLMFLKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLH 160
Cdd:PRK11397 81 RITPDDIVTVGRDAWAKDNPVFVGSSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 161 LQDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPDVYHMYSQKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAG 240
Cdd:PRK11397 161 LKDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 241 FNLIASAVDGQRRLIAVVMGADSPKGREQQAAKLLHWGQQNFDTVQVLQKGKKVGSERIWYGDKEQIQLGTDQDFWLALP 320
Cdd:PRK11397 241 FNLIASAVDGQRRLIAVVMGADSAKGREEQARKLLRWGQQNFTTVQILHRGKKVGTERIWYGDKENIALGTEQDFWMVLP 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 921140243 321 KSEVTRIKARYVLDKKDLEAPIAANQRVGEISLYDGDKVVAHWPLVTLESVGKGGVFSRMSDYLHH 386
Cdd:PRK11397 321 KAEIPHIKAKYVLDGKELEAPISAHQRVGEIELYDRDKQVAHWPLVTLESVGEGGMFSRLSDYFHH 386
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-379 |
7.11e-138 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 396.13 E-value: 7.11e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 1 MKGRFFIAVTLLASSVSCAFAAndfpvtvpPPSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSH 80
Cdd:COG1686 1 MKKLLLLALLLLLAAAAAAPAA--------PPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 81 RISFDDMVTVGRDAWAKGnpvfdgSSLMFLKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLH 160
Cdd:COG1686 73 KISLDDKVTVSEEAARTG------GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 161 LQDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPDVYHMYSQKSLTWN---GITQQNRNGLLWdKTMNVDGLKTGHTS 237
Cdd:COG1686 147 MTNTHFVNPTGLPDPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPngrGITLRNTNRLLG-RYPGVDGLKTGYTD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 238 GAGFNLIASAVDGQRRLIAVVMGADSPKGREQQAAKLLHWGqqnfdtvqvlqkgkkvgseriwygdkeqiqlgtdqdfwl 317
Cdd:COG1686 226 AAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYG--------------------------------------- 266
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 921140243 318 aLPKSEvtRIKARYVLDkKDLEAPIAANQRVGEISLYDGDKVVAHWPLVTLESVGKGGVFSR 379
Cdd:COG1686 267 -FPKGE--ALKAEVVLD-GPLKAPVKKGQVVGTLVVTLDGKTIAEVPLVAAEDVEKAGFFSR 324
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
29-262 |
5.42e-125 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 359.78 E-value: 5.42e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 29 VPPPSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRISFDDMVTVGRDAWAKGNPvfdGSSLM 108
Cdd:pfam00768 1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP---GSSNI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 109 FLKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLHLQDTHFETVHGLDAPGQHSSAYDLAVLS 188
Cdd:pfam00768 78 FLKPGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHGQYSSARDMAILA 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 921140243 189 RAIIHGEPDVYHMYSQKSLTW---NGITQQNRNGLLWDKTMNVDGLKTGHTSGAGFNLIASAVDGQRRLIAVVMGAD 262
Cdd:pfam00768 158 KALIKDLPEELSITKEKSFTFrgiNKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATKGGMRLISVVMGAF 234
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
46-292 |
2.49e-33 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 127.40 E-value: 2.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 46 TGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRISFDDMVTVgRDAWAKGNPVFDGSSLMfLKAGDRVSVRDLSRGL 125
Cdd:NF038258 49 TGQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKI-TSDYEKMSTLPNLSTFP-LKPGQTYTIKELLKQT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 126 IVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLHLQDTHFETVHGLD-------APGQ-------HSSAYDLAVLSRAI 191
Cdd:NF038258 127 ALASSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADnnllkpyAPKKykdetksKSTAKDMAILSQHL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 192 IHGEPDVYHMYSQKSLTWNGITQQNRNGLLWDKTM---NVDGLKTGhTSGAGFNLIASAVDGQRRLIAVVMGA-DSP--- 264
Cdd:NF038258 207 IKKHPKILKYTKLTADTQHGVTLYTTNLSLPGQPMslkGTDGLKTG-TSDEGYNLALTTKRDGLRINQVIMNVgPYPseg 285
|
250 260 270
....*....|....*....|....*....|
gi 921140243 265 --KGREQQAAKLLHWGQQNFDTVQVLQKGK 292
Cdd:NF038258 286 akHARNKIANALMERAFKQYEYKKVLSKGE 315
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
282-373 |
2.47e-30 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 111.54 E-value: 2.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 282 FDTVQVLQKGKKVGSERIWYGDKEQIQLGTDQDFWLALPKSEVTRIKARYVLDKKDLEAPIAANQRVGEISLYDGDKVVA 361
Cdd:smart00936 1 FETVKLYKKGQVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVTLDGKLIG 80
|
90
....*....|..
gi 921140243 362 HWPLVTLESVGK 373
Cdd:smart00936 81 EVPLVALEDVEK 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| dacD |
PRK11397 |
serine-type D-Ala-D-Ala carboxypeptidase DacD; |
1-386 |
0e+00 |
|
serine-type D-Ala-D-Ala carboxypeptidase DacD;
Pssm-ID: 183117 [Multi-domain] Cd Length: 388 Bit Score: 824.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 1 MKGRFFIAVTLLASSVSCAFAANDFPVTVPPPSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSH 80
Cdd:PRK11397 1 LKRRLIIAASLFAFNLSSAFAAENIPFSPQPPAIDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 81 RISFDDMVTVGRDAWAKGNPVFDGSSLMFLKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLH 160
Cdd:PRK11397 81 RITPDDIVTVGRDAWAKDNPVFVGSSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 161 LQDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPDVYHMYSQKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAG 240
Cdd:PRK11397 161 LKDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 241 FNLIASAVDGQRRLIAVVMGADSPKGREQQAAKLLHWGQQNFDTVQVLQKGKKVGSERIWYGDKEQIQLGTDQDFWLALP 320
Cdd:PRK11397 241 FNLIASAVDGQRRLIAVVMGADSAKGREEQARKLLRWGQQNFTTVQILHRGKKVGTERIWYGDKENIALGTEQDFWMVLP 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 921140243 321 KSEVTRIKARYVLDKKDLEAPIAANQRVGEISLYDGDKVVAHWPLVTLESVGKGGVFSRMSDYLHH 386
Cdd:PRK11397 321 KAEIPHIKAKYVLDGKELEAPISAHQRVGEIELYDRDKQVAHWPLVTLESVGEGGMFSRLSDYFHH 386
|
|
| PRK10793 |
PRK10793 |
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional |
10-386 |
2.63e-160 |
|
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
Pssm-ID: 182736 [Multi-domain] Cd Length: 403 Bit Score: 456.24 E-value: 2.63e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 10 TLLASSVSCAFAANDFPV-TVPP--PSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRISFDD 86
Cdd:PRK10793 17 TALCTAFISAAHADDLNIkTMIPgvPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 87 MVTVGRDAWAKGNPVFDGSSLMFLKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLHLQDTHF 166
Cdd:PRK10793 97 LVTVGNDAWATGNPVFKGSSLMFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVNALGLKNTHF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 167 ETVHGLDAPGQHSSAYDLAVLSRAIIHGEPDVYHMYSQKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAGFNLIAS 246
Cdd:PRK10793 177 QTVHGLDADGQYSSARDMALIGQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLNVDGIKTGHTDKAGYNLVAS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 247 AVDGQRRLIAVVMGADSPKGREQQAAKLLHWGQQNFDTVQVLQKGKKVGSERIWYGDKEQIQLGTDQDFWLALPKSEVTR 326
Cdd:PRK10793 257 ATEGQMRLISAVMGGRTFKGRETESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASLGVDKDVYLTIPRGRMKD 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 921140243 327 IKARYVLDKKDLEAPIAANQRVGEISLYDGDKVVAHWPLVTLESVGKGGVFSRMSDYL----HH 386
Cdd:PRK10793 337 LKASYVLNTSELHAPLQKNQVVGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIklmfHH 400
|
|
| PRK10001 |
PRK10001 |
serine-type D-Ala-D-Ala carboxypeptidase; |
11-384 |
4.52e-144 |
|
serine-type D-Ala-D-Ala carboxypeptidase;
Pssm-ID: 182189 [Multi-domain] Cd Length: 400 Bit Score: 414.78 E-value: 4.52e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 11 LLASSVSCAFAANDfpvTVPPPSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRISFDDMVTV 90
Cdd:PRK10001 17 FLFLFAPTAFAAEQ---TVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQALKADKIKLTDMVTV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 91 GRDAWAKGNPVFDGSSLMFLKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLHLQDTHFETVH 170
Cdd:PRK10001 94 GKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAKKLGLTNTTFQTVH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 171 GLDAPGQHSSAYDLAVLSRAIIHGEPDVYHMYSQKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAGFNLIASAVDG 250
Cdd:PRK10001 174 GLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTAGAGYNLVASATQG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 251 QRRLIAVVMGADSPKGREQQAAKLLHWGQQNFDTVQVLQKGKKVGSERIWYGDKEQIQLGTDQDFWLALPKSEVTRIKAR 330
Cdd:PRK10001 254 DMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSVTIPRGQLKNLKAS 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 921140243 331 YVLDKKDLEAPIAANQRVGEISLYDGDKVVAHWPLVTLESVGKGGVFSRMSDYL 384
Cdd:PRK10001 334 YTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFSRMWDFV 387
|
|
| DacC |
COG1686 |
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis]; |
1-379 |
7.11e-138 |
|
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441292 [Multi-domain] Cd Length: 324 Bit Score: 396.13 E-value: 7.11e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 1 MKGRFFIAVTLLASSVSCAFAAndfpvtvpPPSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSH 80
Cdd:COG1686 1 MKKLLLLALLLLLAAAAAAPAA--------PPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 81 RISFDDMVTVGRDAWAKGnpvfdgSSLMFLKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLH 160
Cdd:COG1686 73 KISLDDKVTVSEEAARTG------GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 161 LQDTHFETVHGLDAPGQHSSAYDLAVLSRAIIHGEPDVYHMYSQKSLTWN---GITQQNRNGLLWdKTMNVDGLKTGHTS 237
Cdd:COG1686 147 MTNTHFVNPTGLPDPGHYSTARDLALLARAAIKDYPEFYEIFSTKEFTFPngrGITLRNTNRLLG-RYPGVDGLKTGYTD 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 238 GAGFNLIASAVDGQRRLIAVVMGADSPKGREQQAAKLLHWGqqnfdtvqvlqkgkkvgseriwygdkeqiqlgtdqdfwl 317
Cdd:COG1686 226 AAGYCLVASAKRGGRRLIAVVLGAPSEKARFADAAKLLDYG--------------------------------------- 266
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 921140243 318 aLPKSEvtRIKARYVLDkKDLEAPIAANQRVGEISLYDGDKVVAHWPLVTLESVGKGGVFSR 379
Cdd:COG1686 267 -FPKGE--ALKAEVVLD-GPLKAPVKKGQVVGTLVVTLDGKTIAEVPLVAAEDVEKAGFFSR 324
|
|
| Peptidase_S11 |
pfam00768 |
D-alanyl-D-alanine carboxypeptidase; |
29-262 |
5.42e-125 |
|
D-alanyl-D-alanine carboxypeptidase;
Pssm-ID: 425859 [Multi-domain] Cd Length: 234 Bit Score: 359.78 E-value: 5.42e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 29 VPPPSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRISFDDMVTVGRDAWAKGNPvfdGSSLM 108
Cdd:pfam00768 1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP---GSSNI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 109 FLKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLHLQDTHFETVHGLDAPGQHSSAYDLAVLS 188
Cdd:pfam00768 78 FLKPGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHGQYSSARDMAILA 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 921140243 189 RAIIHGEPDVYHMYSQKSLTW---NGITQQNRNGLLWDKTMNVDGLKTGHTSGAGFNLIASAVDGQRRLIAVVMGAD 262
Cdd:pfam00768 158 KALIKDLPEELSITKEKSFTFrgiNKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATKGGMRLISVVMGAF 234
|
|
| PBP4_Staph |
NF038258 |
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), ... |
46-292 |
2.49e-33 |
|
penicillin-binding protein PBP4; Members of this family penicillin-binding protein 4 (PBP4), as the name is used in Staphylococcus aureus and related species from the same genus. PBP4 is not essential. It has transpeptidase activity, provides low level beta-lactam resistance, and in mutant strains can contribute to high level beta-lactam resistance.
Pssm-ID: 468436 [Multi-domain] Cd Length: 365 Bit Score: 127.40 E-value: 2.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 46 TGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRISFDDMVTVgRDAWAKGNPVFDGSSLMfLKAGDRVSVRDLSRGL 125
Cdd:NF038258 49 TGQILYDYHGNKKWDPASMTKLMTMYLTLEAIKKGKLSLNDKVKI-TSDYEKMSTLPNLSTFP-LKPGQTYTIKELLKQT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 126 IVDSGNDACVALADYVAGGQPQFVAMMNEYVKKLHLQDTHFETVHGLD-------APGQ-------HSSAYDLAVLSRAI 191
Cdd:NF038258 127 ALASSNAAALILAEKVSGNTSKFTDRMNEKAKALGMKHTHFTNPSGADnnllkpyAPKKykdetksKSTAKDMAILSQHL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 192 IHGEPDVYHMYSQKSLTWNGITQQNRNGLLWDKTM---NVDGLKTGhTSGAGFNLIASAVDGQRRLIAVVMGA-DSP--- 264
Cdd:NF038258 207 IKKHPKILKYTKLTADTQHGVTLYTTNLSLPGQPMslkGTDGLKTG-TSDEGYNLALTTKRDGLRINQVIMNVgPYPseg 285
|
250 260 270
....*....|....*....|....*....|
gi 921140243 265 --KGREQQAAKLLHWGQQNFDTVQVLQKGK 292
Cdd:NF038258 286 akHARNKIANALMERAFKQYEYKKVLSKGE 315
|
|
| PBP5_C |
smart00936 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
282-373 |
2.47e-30 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 198004 [Multi-domain] Cd Length: 92 Bit Score: 111.54 E-value: 2.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 282 FDTVQVLQKGKKVGSERIWYGDKEQIQLGTDQDFWLALPKSEVTRIKARYVLDKKDLEAPIAANQRVGEISLYDGDKVVA 361
Cdd:smart00936 1 FETVKLYKKGQVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVTLDGKLIG 80
|
90
....*....|..
gi 921140243 362 HWPLVTLESVGK 373
Cdd:smart00936 81 EVPLVALEDVEK 92
|
|
| PBP5_C |
pfam07943 |
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ... |
282-373 |
2.26e-27 |
|
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.
Pssm-ID: 429749 [Multi-domain] Cd Length: 91 Bit Score: 103.83 E-value: 2.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 282 FDTVQVLQKGKKVGSERIWYGDKEQIQLGTDQDFWLALPKSEVTRIKARYVLdKKDLEAPIAANQRVGEISLYDGDKVVA 361
Cdd:pfam07943 1 FETKKLYKKGDVVKKVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTL-KKPLEAPIKKGQVVGKLEVYLDGKLIG 79
|
90
....*....|..
gi 921140243 362 HWPLVTLESVGK 373
Cdd:pfam07943 80 EVPLVAKEDVEE 91
|
|
| pbpG |
PRK11669 |
D-alanyl-D-alanine endopeptidase; Provisional |
1-261 |
1.69e-18 |
|
D-alanyl-D-alanine endopeptidase; Provisional
Pssm-ID: 236952 Cd Length: 306 Bit Score: 85.12 E-value: 1.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 1 MKGRFFIAVTLLASS---VSCAFAANDFPVTVP--PPSIQAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVdr 75
Cdd:PRK11669 1 MKFRVSLLSLLLLLAgvpFAPQAVAKTAAATTAsqPQEIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVV-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 76 aIDSHrISFDDMVTVGrdawAKGNPVFDGsslMF--LKAGDRVSVRDLSRGLIVDSGNDACVALADYVAGGQPQFVAMMN 153
Cdd:PRK11669 79 -LDAK-LPLDEKLKVD----ISQTPEMKG---VYsrVRLNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 154 EYVKKLHLQDTHFETVHGLdAPGQHSSAYDLAVLSRAIIHgepdvYHMYSQKSLT----------WNGITQQNRNGLLWD 223
Cdd:PRK11669 150 AKAKALGMTNTRYVEPTGL-SIHNVSTARDLTKLLIASKQ-----YPLIGQLSTTrektatfrkpNYTLPFRNTNHLVYR 223
|
250 260 270
....*....|....*....|....*....|....*...
gi 921140243 224 KTMNVDGLKTGHTSGAGFNLIASAVDGQRRLIAVVMGA 261
Cdd:PRK11669 224 DNWNIQLTKTGFTNAAGHCLVMRTVINNRPVALVVLDA 261
|
|
| PenP |
COG2367 |
Beta-lactamase class A [Defense mechanisms]; |
38-195 |
3.08e-08 |
|
Beta-lactamase class A [Defense mechanisms];
Pssm-ID: 441934 [Multi-domain] Cd Length: 276 Bit Score: 54.52 E-value: 3.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 38 SWVLMDYTTGQILTAgNEHQQRNPASLTKLMTGYVVDRAIDSHRISFDDMVTVGRDAWAKGNPVfdgssLMFLKAGDRVS 117
Cdd:COG2367 36 GVYVLDLDTGETVGI-NADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTPEDLVGGSGI-----LQKLPDGTGLT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 118 VRDLSRGLIVDSGNDACVALADYVagGQPQFvammNEYVKKLHLQDTHFE-TVHGL-DAPGQH---SSAYDLAVLSRAII 192
Cdd:COG2367 110 LRELAELMITVSDNTATNLLLRLL--GPDAV----NAFLRSLGLTDTRLDrKEPDLnELPGDGrntTTPRDMARLLAALY 183
|
...
gi 921140243 193 HGE 195
Cdd:COG2367 184 RGE 186
|
|
| Beta-lactamase2 |
pfam13354 |
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ... |
38-195 |
1.25e-07 |
|
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.
Pssm-ID: 463854 [Multi-domain] Cd Length: 215 Bit Score: 51.89 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 38 SWVLMDYTTGQILtAGNEHQQRNPASLTKLMTGYVVDRAIDSHRISFDDMVTVGRDawakgnPVFDGSSLM-FLKAGDRV 116
Cdd:pfam13354 1 GIYVRDLDTGEEL-GINGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAE------DKVGGSGILqYLPDGSQL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921140243 117 SVRDLSRGLIVDSGNDACVALADYVagGQPQFvammNEYVKKLHLQDTHFE----TVHGLDAPGQH-SSAYDLAVLSRAI 191
Cdd:pfam13354 74 SLRDLLTLMIAVSDNTATNLLIDRL--GLEAV----NARLRALGLRDTRLRrklpDLRAADKGGTNtTTARDMAKLLEAL 147
|
....
gi 921140243 192 IHGE 195
Cdd:pfam13354 148 YRGE 151
|
|
| |
