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Conserved domains on  [gi|921961071|ref|WP_053254879|]
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methyl-accepting chemotaxis protein [Pseudomonas fluorescens]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
15-540 1.06e-90

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 288.07  E-value: 1.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  15 ALVTLGVGMLGIKGVVRLANALELTFSNNLVSVSNTASTLNGLVAHNRGLYRLLDASNGNVNQQDRDRVRQDIASELKRS 94
Cdd:COG0840    8 LALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  95 QTAYATYRATPLEDDERVAGDKLDQIWPNYVSSSERIISMLDSGQTEQARTQLNTTNNELFRQARELIRVMIESNNRQIK 174
Cdd:COG0840   88 LLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 175 EGAIAAEALRDSALTWMISGIVLAFIIAITIGLLITRLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDM 254
Cdd:COG0840  168 EAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRM 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 255 QGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNAVSTSQASRQATTEAEE 334
Cdd:COG0840  248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 335 GRQQVEQAVSGMESMVVEINDSTQSVADLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRA 414
Cdd:COG0840  328 GGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRK 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 415 LAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLVIASASEEQAQVAR 494
Cdd:COG0840  408 LAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTE 487

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 921961071 495 EVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSFNVLVSKFQL 540
Cdd:COG0840  488 EVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
15-540 1.06e-90

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 288.07  E-value: 1.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  15 ALVTLGVGMLGIKGVVRLANALELTFSNNLVSVSNTASTLNGLVAHNRGLYRLLDASNGNVNQQDRDRVRQDIASELKRS 94
Cdd:COG0840    8 LALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  95 QTAYATYRATPLEDDERVAGDKLDQIWPNYVSSSERIISMLDSGQTEQARTQLNTTNNELFRQARELIRVMIESNNRQIK 174
Cdd:COG0840   88 LLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 175 EGAIAAEALRDSALTWMISGIVLAFIIAITIGLLITRLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDM 254
Cdd:COG0840  168 EAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRM 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 255 QGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNAVSTSQASRQATTEAEE 334
Cdd:COG0840  248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 335 GRQQVEQAVSGMESMVVEINDSTQSVADLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRA 414
Cdd:COG0840  328 GGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRK 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 415 LAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLVIASASEEQAQVAR 494
Cdd:COG0840  408 LAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTE 487

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 921961071 495 EVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSFNVLVSKFQL 540
Cdd:COG0840  488 EVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 278-539 2.88e-63

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 207.52  E-value: 2.88e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   278 ELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMESMVVEINDST 357
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   358 QSVADLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQTSTVDIEKMIGDVQLGA 437
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEET 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   438 DDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLVIASASEEQAQVAREVDRNLLNIQDLSTQTAAGAHQT 517
Cdd:smart00283 161 NEAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 921961071   518 NASSQDLSRLATSFNVLVSKFQ 539
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 305-504 8.44e-49

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 167.41  E-value: 8.44e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 305 NQMTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMESMVVEINDSTQSVADLANQVREIGKVIDVIRSIADQT 384
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 385 NLLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQA 464
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 921961071 465 LQRITTSVAMINERNLVIASASEEQAQVAREVDRNLLNIQ 504
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-540 3.77e-43

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 161.66  E-value: 3.77e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   1 MKISTKLLLSFVLCALVTLGVGMLGIKG---------VVRLANALELTFSNNLVSVSNTASTLNglvahNRGLYRLLDAS 71
Cdd:PRK15041   5 IKIVTSLLLVLAVFGLLQLTSGGLFFNAlkndkenftVLQTIRQQQSTLNGSWVALLQTRNTLN-----RAGIRYMMDQN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  72 NGNVNQQDRDrVRQDIASELKRSQTAYATYRATPLedDERVAGDKLDQIWPNYV---SSSERIISMLDSGQTEQARTQLN 148
Cdd:PRK15041  80 NIGSGSTVAE-LMQSASISLKQAEKNWADYEALPR--DPRQSTAAAAEIKRNYDiyhNALAELIQLLGAGKINEFFDQPT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 149 TTNNELFRQARelirVMIESNNRQIKEGAIAAEALRDSALTWMISGI---VLAFIIAITIGllITRLITRPIAQAVESAQ 225
Cdd:PRK15041 157 QGYQDGFEKQY----VAYMEQNDRLYDIAVSDNNASYSQAMWILVGVmivVLAVIFAVWFG--IKASLVAPMNRLIDSIR 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 226 RIAKGDLTHAIVTERTDEAGQLLMALSDMQGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAATAVN 305
Cdd:PRK15041 231 HIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASME 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 306 QMTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMEsmvvEINDSTQSVADlanqvreigkVIDVIRSIADQTN 385
Cdd:PRK15041 311 QLTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMR----DISTSSQKIAD----------IISVIDGIAFQTN 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 386 LLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQTSTVDIEKMIGDvqlgaddavaamnkSLSWANDTQALAQNAGQAL 465
Cdd:PRK15041 377 ILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIED--------------SVGKVDVGSTLVESAGETM 442

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 921961071 466 QRITTSVAMINERNLVIASASEEQAQVAREVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSFNVLVSKFQL 540
Cdd:PRK15041 443 AEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRI 517
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 322-507 5.60e-34

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 126.39  E-value: 5.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  322 SQASRQATTEAEEGRQQVEQAVSGMEsmvveindstqsvaDLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQ 401
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQME--------------QIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  402 GRGFAVVADEVRALAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLV 481
Cdd:pfam00015  67 GRGFAVVADEVRKLAERSAQAAKEIEALIIEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQE 146

                         170       180
                  ....*....|....*....|....*.
gi 921961071  482 IASASEEQAQVAREVDRNLLNIQDLS 507
Cdd:pfam00015 147 IAAASDEQSAGIDQVNQAVARMDQVT 172
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
15-540 1.06e-90

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 288.07  E-value: 1.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  15 ALVTLGVGMLGIKGVVRLANALELTFSNNLVSVSNTASTLNGLVAHNRGLYRLLDASNGNVNQQDRDRVRQDIASELKRS 94
Cdd:COG0840    8 LALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  95 QTAYATYRATPLEDDERVAGDKLDQIWPNYVSSSERIISMLDSGQTEQARTQLNTTNNELFRQARELIRVMIESNNRQIK 174
Cdd:COG0840   88 LLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 175 EGAIAAEALRDSALTWMISGIVLAFIIAITIGLLITRLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDM 254
Cdd:COG0840  168 EAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRM 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 255 QGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNAVSTSQASRQATTEAEE 334
Cdd:COG0840  248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 335 GRQQVEQAVSGMESMVVEINDSTQSVADLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRA 414
Cdd:COG0840  328 GGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRK 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 415 LAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLVIASASEEQAQVAR 494
Cdd:COG0840  408 LAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTE 487

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 921961071 495 EVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSFNVLVSKFQL 540
Cdd:COG0840  488 EVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 278-539 2.88e-63

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 207.52  E-value: 2.88e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   278 ELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMESMVVEINDST 357
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   358 QSVADLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQTSTVDIEKMIGDVQLGA 437
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEET 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   438 DDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLVIASASEEQAQVAREVDRNLLNIQDLSTQTAAGAHQT 517
Cdd:smart00283 161 NEAVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 921961071   518 NASSQDLSRLATSFNVLVSKFQ 539
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 305-504 8.44e-49

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 167.41  E-value: 8.44e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 305 NQMTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMESMVVEINDSTQSVADLANQVREIGKVIDVIRSIADQT 384
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 385 NLLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQA 464
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 921961071 465 LQRITTSVAMINERNLVIASASEEQAQVAREVDRNLLNIQ 504
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-540 3.77e-43

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 161.66  E-value: 3.77e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   1 MKISTKLLLSFVLCALVTLGVGMLGIKG---------VVRLANALELTFSNNLVSVSNTASTLNglvahNRGLYRLLDAS 71
Cdd:PRK15041   5 IKIVTSLLLVLAVFGLLQLTSGGLFFNAlkndkenftVLQTIRQQQSTLNGSWVALLQTRNTLN-----RAGIRYMMDQN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  72 NGNVNQQDRDrVRQDIASELKRSQTAYATYRATPLedDERVAGDKLDQIWPNYV---SSSERIISMLDSGQTEQARTQLN 148
Cdd:PRK15041  80 NIGSGSTVAE-LMQSASISLKQAEKNWADYEALPR--DPRQSTAAAAEIKRNYDiyhNALAELIQLLGAGKINEFFDQPT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 149 TTNNELFRQARelirVMIESNNRQIKEGAIAAEALRDSALTWMISGI---VLAFIIAITIGllITRLITRPIAQAVESAQ 225
Cdd:PRK15041 157 QGYQDGFEKQY----VAYMEQNDRLYDIAVSDNNASYSQAMWILVGVmivVLAVIFAVWFG--IKASLVAPMNRLIDSIR 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 226 RIAKGDLTHAIVTERTDEAGQLLMALSDMQGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAATAVN 305
Cdd:PRK15041 231 HIAGGDLVKPIEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASME 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 306 QMTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMEsmvvEINDSTQSVADlanqvreigkVIDVIRSIADQTN 385
Cdd:PRK15041 311 QLTATVKQNAENARQASHLALSASETAQRGGKVVDNVVQTMR----DISTSSQKIAD----------IISVIDGIAFQTN 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 386 LLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQTSTVDIEKMIGDvqlgaddavaamnkSLSWANDTQALAQNAGQAL 465
Cdd:PRK15041 377 ILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIED--------------SVGKVDVGSTLVESAGETM 442

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 921961071 466 QRITTSVAMINERNLVIASASEEQAQVAREVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSFNVLVSKFQL 540
Cdd:PRK15041 443 AEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRI 517
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 76-540 1.22e-40

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 154.39  E-value: 1.22e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  76 NQQDRDRVR--QDIASELKRSQTAYATYRA-TPLEDDERVAGDkLDQIWPNYVSSSERIISMLDSGQTEQARTQLNTTnn 152
Cdd:PRK15048  80 NQQSNAKVEllDSARKTLAQAATHYKKFKSmAPLPEMVATSRN-IDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQG-- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 153 elfrqarelirvMIESNNRQIKEGAIAAEALRDSALT----------WMISGIVLAF-IIAITIGLLITRLITRPIAQAV 221
Cdd:PRK15048 157 ------------MQNAMGEAFAQYALSSEKLYRDIVTdnaddyrfaqWQLAVIALVVvLILLVAWYGIRRMLLTPLAKII 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 222 ESAQRIAKGDLTHAIVTERTDEAGQLLMALSDMQGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAA 301
Cdd:PRK15048 225 AHIREIAGGNLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETA 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 302 TAVNQMTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMEsmvvEINDSTQSVADlanqvreigkVIDVIRSIA 381
Cdd:PRK15048 305 ASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMH----EIADSSKKIAD----------IISVIDGIA 370

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 382 DQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHRTQTSTVDIEKMIGDvqlgaddavaamnkSLSWANDTQALAQNA 461
Cdd:PRK15048 371 FQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIED--------------SVSRVDTGSVLVESA 436

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 921961071 462 GQALQRITTSVAMINERNLVIASASEEQAQVAREVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSFNVLVSKFQL 540
Cdd:PRK15048 437 GETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRL 515
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
178-540 6.54e-38

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 146.37  E-value: 6.54e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 178 IAAEALRDSALTWMISGIVlaFIIAITIGLLIT--------RLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLM 249
Cdd:PRK09793 173 VLEAASAQSQRNYQISALV--FISMIIVAAIYIssalwwtrKMIVQPLAIIGSHFDSIAAGNLARPIAVYGRNEITAIFA 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 250 ALSDMQGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNAVSTSQASRQAT 329
Cdd:PRK09793 251 SLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTATVGQNADNARQASELAKNAA 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 330 TEAEEGRQQVEQAVSGMEsmvveindstqsvaDLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQGRGFAVVA 409
Cdd:PRK09793 331 TTAQAGGVQVSTMTHTMQ--------------EIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 396

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 410 DEVRALAHRTQTSTVDIEKMIgdvqlgaddavaamNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLVIASASEEQ 489
Cdd:PRK09793 397 GEVRNLASRSAQAAKEIKGLI--------------EESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQ 462

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 921961071 490 AQVAREVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSFNVLVSKFQL 540
Cdd:PRK09793 463 RRGIEQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTL 513
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 322-507 5.60e-34

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 126.39  E-value: 5.60e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  322 SQASRQATTEAEEGRQQVEQAVSGMEsmvveindstqsvaDLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQ 401
Cdd:pfam00015   1 SDLAQLASEEAQDGGKEVANVVGQME--------------QIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  402 GRGFAVVADEVRALAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLV 481
Cdd:pfam00015  67 GRGFAVVADEVRKLAERSAQAAKEIEALIIEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQE 146

                         170       180
                  ....*....|....*....|....*.
gi 921961071  482 IASASEEQAQVAREVDRNLLNIQDLS 507
Cdd:pfam00015 147 IAAASDEQSAGIDQVNQAVARMDQVT 172
4HB_MCP_1 pfam12729
Four helix bundle sensory module for signal transduction; This family is a four helix bundle ...
 1-175 1.45e-14

Four helix bundle sensory module for signal transduction; This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterized in E coli chemoreceptors. This domain recognizes citrate and TCA cycle intermediates, cis-aconitate, boric acid, Phenanthrene, pyrene and benzopyrene (Matilla et el., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 432749 [Multi-domain]  Cd Length: 181  Bit Score: 71.90  E-value: 1.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071    1 MKISTKLLLSFVLCALVTLGVGMLGIKGVVRLANALELTFSNNLVSVsNTASTLNGLVAHNRG-LYRLLDASNgnvnQQD 79
Cdd:pfam12729   2 LKIRTKLILLFLLLALLLIIVGVVGLYSLKQINDNLDTMYEDRLLPI-KWLGDIRANLLELRAnLLELILTTD----PAE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   80 RDRVRQDIASELKRSQTAYATYRATPLEDDERVAGDKLDQIWPNYVSSSERIISMLDSGQTEQARTQLNTTNNELFRQAR 159
Cdd:pfam12729  77 RDELLKDIEELRAEIDKLLEKYEKTILTDEEKKLFAEFKENLNAYRAVRNKVLELAKAGNKDEAYQLYKTEGRPAREAMI 156

                         170
                  ....*....|....*.
gi 921961071  160 ELIRVMIESNNRQIKE 175
Cdd:pfam12729 157 EALEELVDYNLKVAKE 172
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
15-536 9.74e-09

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 58.20  E-value: 9.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  15 ALVTLGVGMLGIKGVVRLANALELTFSNNLVSVSNTASTLNGLVAHNRGLYRLLDASNGNVNQQDRDRVRQDIASELKRS 94
Cdd:COG2770   39 LLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAAL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  95 QTAYATYRATPLEDDERVAGDKLDQIWPNYVSSSERIISMLDSGQTEQARTQLNTTNNELFRQARELIRVMIESNNRQIK 174
Cdd:COG2770  119 ALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGL 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 175 EGAIAAEALRDSALTWMISGIVlAFIIAITIGLLITRLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDM 254
Cdd:COG2770  199 LLVVLLEAALAALLLLLLLALL-ALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRM 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 255 QGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNAVSTSQASRQATTEAEE 334
Cdd:COG2770  278 ADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALA 357

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 335 GRQQ--VEQAVSGMESMVVEINDSTQSVADLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQGRGFAVVADEV 412
Cdd:COG2770  358 ALLLllALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAA 437

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 413 RALAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINERNLVIASASEEQAQV 492
Cdd:COG2770  438 LELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLL 517

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 921961071 493 AREVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSFNVLVS 536
Cdd:COG2770  518 LLLLEAEALEVAEELLELEEAALLLAAAAELAALLALLLALAAV 561
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 139-391 1.38e-08

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 57.39  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 139 QTEQARTQLNTTNNELFRQARELIRVMIESNNRQIKEGAIAAEALRDSALTWMISGIVLAFIIAITIG-LLITRLITRPI 217
Cdd:COG4192  276 AAQATLEALAEENNSILEQLRTQISGLVGNSREQLVALNQETAQLVQQSGILLLAIALLSLLLAVLINyFYVRRRLVKRL 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 218 AQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALsdmqgglkstLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEI 297
Cdd:COG4192  356 NALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLL----------RVFRDQAIEKTQELETEIEERKRIEKNLRQTQDELI 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 298 QQAATAV--NQMTTAVDEVAS--NAVSTSQASRQATTEaEEGRQQVEQAVSGMESMVVEINDSTQSVADLANQVREIGKV 373
Cdd:COG4192  426 QAAKMAVvgQTMTSLAHELNQplNAMSMYLFSAKKALE-QENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP 504

                        250
                 ....*....|....*...
gi 921961071 374 IDVIRSIADQTNLLALNA 391
Cdd:COG4192  505 VDLRQVIEQAWELVESRA 522
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 196-281 8.36e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 51.50  E-value: 8.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 196 VLAFIIAITIGLLITRLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDMQGGLKSTLVEIANAADQLASA 275
Cdd:COG5000   16 LLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQREELEERRRYLETI 95


                 ....*.
gi 921961071 276 AEELSA 281
Cdd:COG5000   96 LENLPA 101
HAMP pfam00672
HAMP domain;
208-259 9.77e-07

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 45.69  E-value: 9.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 921961071  208 LITRLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDMQGGLK 259
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLR 52
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 214-258 1.87e-06

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 44.74  E-value: 1.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 921961071 214 TRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDMQGGL 258
Cdd:cd06225    1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
123-281 8.89e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 48.09  E-value: 8.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 123 NYVSSSERIISMLDSGQTEQARTQLNTTNNELFRQARELIRVMIESNNRQIKEGAIAAEALRDSA---LTWMISGIVLAF 199
Cdd:COG2972   88 LLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLfslRRLILLIILLLL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 200 IIAITIGLLITRLITRPIAQAVESAQRIAKGDLTHaIVTERTDEAGQLLMALSDMQGGLKSTLVEIANAADQLASAaeEL 279
Cdd:COG2972  168 LLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKEA--EL 244


                 ..
gi 921961071 280 SA 281
Cdd:COG2972  245 KA 246
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
211-262 3.20e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 41.46  E-value: 3.20e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 921961071   211 RLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDMQGGLKSTL 262
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETI 52
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 191-419 3.26e-05

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 46.42  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 191 MISGIVLAFIIAITIGLLITRLITRPIAQAVESAQRIAKGDLTHAIVTERTDEAGQLLMALSDMQGGLKSTLVEIANAAD 270
Cdd:COG3850  120 ALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELYAELEEEEE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 271 QLASAAEELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMESMV 350
Cdd:COG3850  200 LEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALL 279

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 921961071 351 VEINDSTQSVADLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAHRT 419
Cdd:COG3850  280 LLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILA 348
PHA03332 PHA03332
membrane glycoprotein; Provisional
 307-475 6.93e-04

membrane glycoprotein; Provisional


Pssm-ID: 223047 [Multi-domain]  Cd Length: 1328  Bit Score: 42.65  E-value: 6.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  307 MTTAVDEVASNAVSTSQASRQATTEAEEGRQQVEQAVSGMESmvvEINDSTQSVADLANQVREIGKVIDVIrSIADQTNL 386
Cdd:PHA03332  857 LSAAAFTMASAALNAATQALAVATLYVNQLLQATAATAEMAS---KIGGLNARVDKTSDVITKLGDTIAKI-SATLDNNI 932

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  387 LALNAAIEAARAGEQGRgFAVVADEVRALAHRTQTSTVDIekmigdvqlgaDDAVAAMNKSLSWANDTQALAQNAGQALQ 466
Cdd:PHA03332  933 RAVNGRVSDLEDQVNLR-FLAVATNFNTLATQLKELGTTT-----------NERIEEVMAAALYYQQLNSLTNQVTQSAS 1000


                  ....*....
gi 921961071  467 RITTSVAMI 475
Cdd:PHA03332 1001 KLGYQVGMY 1009
CHASE3 COG5278
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
1-531 1.19e-03

Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];


Pssm-ID: 444089 [Multi-domain]  Cd Length: 530  Bit Score: 41.43  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071   1 MKISTKLLLSFVLCALVTLGVGMLGIKGVVRLANALELTfsNNLVSVSNTASTLNGLVAHNRGLYRLLDASNGNVNQQDR 80
Cdd:COG5278    4 LSIRRKLLLGFALALLLLLVLGVLSYLSLNRLREASEWV--EHTYEVLRALEELLSALLDAETGQRGYLLTGDESFLEPY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071  81 DRVRQDIASELKRSQTAYATyratplEDDERVAGDKLDQIWPNYVSSSERIISMLDSGQTEQARTQLNT-TNNELFRQAR 159
Cdd:COG5278   82 EEARAEIDELLAELRSLTAD------NPEQQARLDELEALIDQWLAELEQVIALRRAGGLEAALALVRSgEGKALMDEIR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 160 ELIRVMIESNNRQIKEGAIAAEALRDSALTWMISGIVLAFIIAITIGLLITRLITRPIAQAVESAQRIAKGDLTHA-IVT 238
Cdd:COG5278  156 ARLLLLALALAALLLAAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAAlELL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 239 ERTDEAGQLLMALSDMQGGLKSTLVEIANAADQLASAAEELSAVTDESTRGLTRQNDEIQQAATAVNQMTTAVDEVASNA 318
Cdd:COG5278  236 AALALALALLLAALLLALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 319 VSTSQASRQATTEAEEGRQQVEQAVSGMESMVVEINDSTQSVADLANQVREIGKVIDVIRSIADQTNLLALNAAIEAARA 398
Cdd:COG5278  316 AAAAAAAAALAALLALALATALAAAAAALALLAALLAEAAAAAAEEAEAAAEAAAAALAGLAEVEAEGAAEAVELEVLAI 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 921961071 399 GEQGRGFAVVADEVRALAHRTQTSTVDIEKMIGDVQLGADDAVAAMNKSLSWANDTQALAQNAGQALQRITTSVAMINER 478
Cdd:COG5278  396 AAAAAAAAAEAAAAAAAAAAASAAEALELAEALAEALALAEEEALALAAASSELAEAGAALALAAAEALAEELAAVAALA 475

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|...
gi 921961071 479 NLVIASASEEQAQVAREVDRNLLNIQDLSTQTAAGAHQTNASSQDLSRLATSF 531
Cdd:COG5278  476 ALAAAAAALAEAEAAAALAAAAALSLALALAALLLAAAEAALAAALAAALASA 528
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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