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Conserved domains on  [gi|922015369|ref|WP_053298539|]
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MULTISPECIES: antitoxin Xre/MbcA/ParS toxin-binding domain-containing protein [Burkholderia]

Protein Classification

DUF2384 domain-containing protein; DUF2384 domain-containing protein; helix-turn-helix domain-containing protein; MbcA/ParS/Xre antitoxin family protein; XRE family transcriptional regulator; helix-turn-helix domain-containing protein; DUF2384 domain-containing protein; MbcA/ParS/Xre antitoxin family protein; MbcA/ParS/Xre antitoxin family protein; Y4oB family protein( domain architecture ID 10009507)

DUF2384 domain-containing protein similar to Mycobacterium tuberculosis Rv1990c; DUF2384 domain-containing protein similar to Mycobacterium tuberculosis Rv1990c; helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator with a DUF2384 domain at the C-terminus; MbcA/ParS/Xre antitoxin family protein similar to Sphingobium sp. Prs ADP-ribosylating antitoxin, the antitoxin component of a type II toxin-antitoxin (TA) system, which neutralizes the bacteriostatic effect of cognate toxin ParT by inserting into its active site; XRE (Xenobiotic Response Element) family transcriptional regulator controls the expression of genes involved in stress response; helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator with a DUF2384 domain at the C-terminus; DUF2384 domain-containing protein similar to Mycobacterium tuberculosis Rv1990c; MbcA/ParS/Xre antitoxin family protein similar to Sphingobium sp. Prs ADP-ribosylating antitoxin, the antitoxin component of a type II toxin-antitoxin (TA) system, which neutralizes the bacteriostatic effect of cognate toxin ParT by inserting into its active site; MbcA/ParS/Xre antitoxin family protein similar to Sphingobium sp. Prs ADP-ribosylating antitoxin, the antitoxin component of a type II toxin-antitoxin (TA) system, which neutralizes the bacteriostatic effect of cognate toxin ParT by inserting into its active site; Y4oB family protein is a DUF2384 domain-containing protein; similar to Sinorhizobium fredii protein Y4oB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5642 COG5642
Uncharacterized conserved protein, DUF2384 family [Function unknown];
15-142 2.31e-34

Uncharacterized conserved protein, DUF2384 family [Function unknown];


:

Pssm-ID: 444366 [Multi-domain]  Cd Length: 139  Bit Score: 116.61  E-value: 2.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922015369  15 LQPVPHTLAELEARVRDGLPKSALRAGVEHAtqGADARRALLARIIPEATYKRRR---DRLTQDESEKTERLARIVATTT 91
Cdd:COG5642   11 LSLSPRSPLDLIELIREGLPASALDRLAELL--GLSDDELAKILGISRRTLSRRKkekKRLSPEESERLLRLARVLARAE 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 922015369  92 YVWNDEEDAREFLSTPHPELEGRTPLDVALTELGARRVEEVLWKLHYGLPA 142
Cdd:COG5642   89 EVFGDEEKARRWLRRPNRALGGRTPLDLLDTEAGAELVEDLLGRIEYGVFA 139
 
Name Accession Description Interval E-value
COG5642 COG5642
Uncharacterized conserved protein, DUF2384 family [Function unknown];
15-142 2.31e-34

Uncharacterized conserved protein, DUF2384 family [Function unknown];


Pssm-ID: 444366 [Multi-domain]  Cd Length: 139  Bit Score: 116.61  E-value: 2.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922015369  15 LQPVPHTLAELEARVRDGLPKSALRAGVEHAtqGADARRALLARIIPEATYKRRR---DRLTQDESEKTERLARIVATTT 91
Cdd:COG5642   11 LSLSPRSPLDLIELIREGLPASALDRLAELL--GLSDDELAKILGISRRTLSRRKkekKRLSPEESERLLRLARVLARAE 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 922015369  92 YVWNDEEDAREFLSTPHPELEGRTPLDVALTELGARRVEEVLWKLHYGLPA 142
Cdd:COG5642   89 EVFGDEEKARRWLRRPNRALGGRTPLDLLDTEAGAELVEDLLGRIEYGVFA 139
TAS_TIGR02293 TIGR02293
putative toxin-antitoxin system antitoxin component, TIGR02293 family; Proteins in this family ...
 25-142 9.51e-19

putative toxin-antitoxin system antitoxin component, TIGR02293 family; Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. This family was proposed by Makarova, et al. (2009) to be the antitoxin component of a new class of type 2 toxin-antitoxin system, or addiction module. [Cellular processes, Other]


Pssm-ID: 131346 [Multi-domain]  Cd Length: 133  Bit Score: 76.34  E-value: 9.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922015369   25 LEARVRDGLPKSALragvEHATQGADARRALLARI--IPEATYKRRR---DRLTQDESEKTERLARIVATTTYVWNDEED 99
Cdd:TIGR02293  15 LISRIERGLPIGAL----DRLAHLLAIGKAEIFKAtgIPKATLQRRKmahQRLSSEESDRLARVARVWKAAVDVFGGDAE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 922015369  100 AREFLSTPHPELEGRTPLDVALTELGARRVEEVLWKLHYGLPA 142
Cdd:TIGR02293  91 ARQWLFRPVPGLGNRRPIDLLLTEAGAEIVEDLLGRLEYGVYA 133
Xre_MbcA_ParS_C pfam09722
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal ...
 93-139 1.15e-12

Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.


Pssm-ID: 462855  Cd Length: 51  Bit Score: 58.69  E-value: 1.15e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 922015369   93 VWNDEEDAREFLSTPHPELEGRTPLDVALTELGARRVEEVLWKLHYG 139
Cdd:pfam09722   5 VFGDDEAAARWLRTPNPALGGRTPLDLLDTEEGLRLVEDYLDRIRGG 51
 
Name Accession Description Interval E-value
COG5642 COG5642
Uncharacterized conserved protein, DUF2384 family [Function unknown];
15-142 2.31e-34

Uncharacterized conserved protein, DUF2384 family [Function unknown];


Pssm-ID: 444366 [Multi-domain]  Cd Length: 139  Bit Score: 116.61  E-value: 2.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922015369  15 LQPVPHTLAELEARVRDGLPKSALRAGVEHAtqGADARRALLARIIPEATYKRRR---DRLTQDESEKTERLARIVATTT 91
Cdd:COG5642   11 LSLSPRSPLDLIELIREGLPASALDRLAELL--GLSDDELAKILGISRRTLSRRKkekKRLSPEESERLLRLARVLARAE 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 922015369  92 YVWNDEEDAREFLSTPHPELEGRTPLDVALTELGARRVEEVLWKLHYGLPA 142
Cdd:COG5642   89 EVFGDEEKARRWLRRPNRALGGRTPLDLLDTEAGAELVEDLLGRIEYGVFA 139
TAS_TIGR02293 TIGR02293
putative toxin-antitoxin system antitoxin component, TIGR02293 family; Proteins in this family ...
 25-142 9.51e-19

putative toxin-antitoxin system antitoxin component, TIGR02293 family; Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. This family was proposed by Makarova, et al. (2009) to be the antitoxin component of a new class of type 2 toxin-antitoxin system, or addiction module. [Cellular processes, Other]


Pssm-ID: 131346 [Multi-domain]  Cd Length: 133  Bit Score: 76.34  E-value: 9.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922015369   25 LEARVRDGLPKSALragvEHATQGADARRALLARI--IPEATYKRRR---DRLTQDESEKTERLARIVATTTYVWNDEED 99
Cdd:TIGR02293  15 LISRIERGLPIGAL----DRLAHLLAIGKAEIFKAtgIPKATLQRRKmahQRLSSEESDRLARVARVWKAAVDVFGGDAE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 922015369  100 AREFLSTPHPELEGRTPLDVALTELGARRVEEVLWKLHYGLPA 142
Cdd:TIGR02293  91 ARQWLFRPVPGLGNRRPIDLLLTEAGAEIVEDLLGRLEYGVYA 133
Xre_MbcA_ParS_C pfam09722
Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal ...
 93-139 1.15e-12

Antitoxin Xre/MbcA/ParS C-terminal toxin-binding domain; This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp.. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect. These antitoxins also have a HTH domain at the N-terminal.


Pssm-ID: 462855  Cd Length: 51  Bit Score: 58.69  E-value: 1.15e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 922015369   93 VWNDEEDAREFLSTPHPELEGRTPLDVALTELGARRVEEVLWKLHYG 139
Cdd:pfam09722   5 VFGDDEAAARWLRTPNPALGGRTPLDLLDTEEGLRLVEDYLDRIRGG 51
Xre-like-HTH pfam20432
Antitoxin Xre-like helix-turn-helix domain; This entry represents the N-terminal domain of the ...
 30-85 1.35e-03

Antitoxin Xre-like helix-turn-helix domain; This entry represents the N-terminal domain of the antitoxin component Xre of a type II toxin-antitoxin (TA) system, which is the helix-turn-helix (HTH) DNA binding domain, structurally similar to the Cro repressor, therefore, also referred to as HTH/Cro-like DNA-binding domain. This domain is also found in other antitoxin components, associated with a C-terminal toxin-binding domain pfam09722.


Pssm-ID: 466581  Cd Length: 57  Bit Score: 34.84  E-value: 1.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 922015369   30 RDGLPKSALRAGVEHAtqgaDARRALLARI--IPEATYKRRR---DRLTQDESEKTERLAR 85
Cdd:pfam20432   1 RAGLPAKAVLRLAEAL----GLTDEELAELlgLSRSTLSRKRkenGRLSPDESERLLRLAR 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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