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Conserved domains on  [gi|923062878|ref|WP_053446571|]
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MULTISPECIES: HAMP domain-containing sensor histidine kinase [Bacillus]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
178-407 6.51e-53

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


:

Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 176.25  E-value: 6.51e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 178 IRKSMHNLLEEKQFLIQTLQDISHQLKTPLSTLTVNNDILLQGK--LNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDA 255
Cdd:COG2205    2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEdlSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 256 RAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEK-ISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNS 334
Cdd:COG2205   82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 923062878 335 PIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG2205  162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 137-171 2.89e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


:

Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 38.19  E-value: 2.89e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 923062878 137 IRNVTAAANKIIEGDYTIDIKENREGDLAKLANSF 171
Cdd:cd06225    4 LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAF 38
Tar super family cl43297
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
10-203 4.96e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0840:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 42.31  E-value: 4.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  10 ILTLALISFLFIIYQVITVHILYDHLKNDYITIWSEITGKLITQNPENEYEIIQALTNDTANKKDYSSDGEMLLNQYGLS 89
Cdd:COG0840   83 ALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  90 AELDSRLFPYLNKHISQNNIYMFLGAIGFSLILIFLNYLQYKSFFLKIRNVTAAANKIIEGDYTIDIKENREGDLAKLAN 169
Cdd:COG0840  163 LAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLAD 242

                        170       180       190
                 ....*....|....*....|....*....|....
gi 923062878 170 SFhklkNVIRKSMHNLLEEKQFLIQTLQDISHQL 203
Cdd:COG0840  243 AF----NRMIENLRELVGQVRESAEQVASASEEL 272
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
178-407 6.51e-53

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 176.25  E-value: 6.51e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 178 IRKSMHNLLEEKQFLIQTLQDISHQLKTPLSTLTVNNDILLQGK--LNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDA 255
Cdd:COG2205    2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEdlSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 256 RAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEK-ISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNS 334
Cdd:COG2205   82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 923062878 335 PIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG2205  162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 98-394 8.30e-26

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 108.78  E-value: 8.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  98 PYLNKhiSQNNIyMFLGAIGFSLILIFLNYLQYKsFFLKIRNVTAAANKIIEGDyTIDIKENREGDLAKLANSFhklknv 177
Cdd:PRK11100 175 PFIKR--SERRI-LWAGALLLGIALLIGAGVVWW-LNRSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQAL------ 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 178 irKSMHNLLEEKQFLIQTLQDISHQLKTPLSTltvnndI-----LLQGKLN-EQQYHFLHNNEVQISRISFLIHNLLKVS 251
Cdd:PRK11100 244 --ESMRVKLEGKAYVEQYVQTLTHELKSPLAA------IrgaaeLLQEDPPpEDRARFTGNILTQSARLQQLIDRLLELA 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 252 KIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETnEKISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEV 331
Cdd:PRK11100 316 RLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSA 394

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 923062878 332 TNSPIHTEIIIQDFGEGIASEDLPYIFDRFY---KAKNSKKegSIGIGLALAKSIIEAHHGFIKVE 394
Cdd:PRK11100 395 EVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK--STGLGLAFVREVARLHGGEVTLR 458
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 302-407 1.55e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 99.65  E-value: 1.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878   302 DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAK-NSKKEGSIGIGLALA 380
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*..
gi 923062878   381 KSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITL 108
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 302-407 7.73e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 92.43  E-value: 7.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  302 DSIWMQEALLNILKNSIEHSNDNSSIYIEVTnSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSiGIGLALAK 381
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGT-GLGLSIVR 79

                          90       100
                  ....*....|....*....|....*.
gi 923062878  382 SIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTL 105
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-407 6.41e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 75.78  E-value: 6.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 302 DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEG-SIGIGLALA 380
Cdd:cd16948    2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQeSTGMGLYLV 81

                         90       100
                 ....*....|....*....|....*..
gi 923062878 381 KSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:cd16948   82 KKLCDKLGHKIDVESEVGEGTTFTITF 108
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 137-171 2.89e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 38.19  E-value: 2.89e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 923062878 137 IRNVTAAANKIIEGDYTIDIKENREGDLAKLANSF 171
Cdd:cd06225    4 LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAF 38
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
10-203 4.96e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 42.31  E-value: 4.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  10 ILTLALISFLFIIYQVITVHILYDHLKNDYITIWSEITGKLITQNPENEYEIIQALTNDTANKKDYSSDGEMLLNQYGLS 89
Cdd:COG0840   83 ALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  90 AELDSRLFPYLNKHISQNNIYMFLGAIGFSLILIFLNYLQYKSFFLKIRNVTAAANKIIEGDYTIDIKENREGDLAKLAN 169
Cdd:COG0840  163 LAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLAD 242

                        170       180       190
                 ....*....|....*....|....*....|....
gi 923062878 170 SFhklkNVIRKSMHNLLEEKQFLIQTLQDISHQL 203
Cdd:COG0840  243 AF----NRMIENLRELVGQVRESAEQVASASEEL 272
 
Name Accession Description Interval E-value
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
178-407 6.51e-53

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 176.25  E-value: 6.51e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 178 IRKSMHNLLEEKQFLIQTLQDISHQLKTPLSTLTVNNDILLQGK--LNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDA 255
Cdd:COG2205    2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEdlSPEERRELLEIIRESAERLLRLIEDLLDLSRLES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 256 RAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEK-ISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNS 334
Cdd:COG2205   82 GKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPElPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARRE 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 923062878 335 PIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG2205  162 GDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
196-407 1.54e-50

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 173.17  E-value: 1.54e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 196 LQDISHQLKTPLSTLTVNNDILLQgKLNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDARAILFEKENSDIIDTIYEVI 275
Cdd:COG0642  114 LANVSHELRTPLTAIRGYLELLLE-ELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVV 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 276 ASLNSKLNKKNMNIHLETNEKISLLH-DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDL 354
Cdd:COG0642  193 ELFRPLAEEKGIELELDLPDDLPTVRgDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDL 272

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 923062878 355 PYIFDRFYKAKNSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG0642  273 ERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
75-407 2.13e-48

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 169.35  E-value: 2.13e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  75 YSSDGEMLLNQYGLSAELDSRLFPYLNKHISQNNIYMFLGAIGFSLILIFLNYLQYKSFFLKIRNVTAAANKIIEGDYTI 154
Cdd:COG5002   47 LLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 155 DIKENREGDLAKLANSFHKLKNVIRKSMHNLLEE-----KQFLiqtlQDISHQLKTPLSTLTVNNDILLQG--KLNEQQY 227
Cdd:COG5002  127 LLLLLGRLSLRLSALLLGLLLLAAVERDITELERleqmrREFV----ANVSHELRTPLTSIRGYLELLLDGaaDDPEERR 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 228 HFLHNNEVQISRISFLIHNLLKVSKIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEKISLLH-DSIWM 306
Cdd:COG5002  203 EYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLgDPDRL 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 307 QEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNS--KKEGSIGIGLALAKSII 384
Cdd:COG5002  283 EQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSrsRETGGTGLGLAIVKHIV 362

                        330       340
                 ....*....|....*....|...
gi 923062878 385 EAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG5002  363 EAHGGRIWVESEPGKGTTFTITL 385
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 199-407 6.66e-27

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 111.21  E-value: 6.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 199 ISHQLKTPLSTLTVNNDIL---LQGKLNEQQYHFLHNNEV---QISRISFLIHNLLKVSKIDARailfEKENSDIIDTIY 272
Cdd:COG5000  208 IAHEIKNPLTPIQLSAERLrrkLADKLEEDREDLERALDTiirQVDRLKRIVDEFLDFARLPEP----QLEPVDLNELLR 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 273 EVIASLNSKLNKKNMNIHLETNEKISLLH-DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIAS 351
Cdd:COG5000  284 EVLALYEPALKEKDIRLELDLDPDLPEVLaDRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPE 363

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 923062878 352 EDLPYIFDRFYKaknSKKEGSiGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG5000  364 EVLERIFEPFFT---TKPKGT-GLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 98-394 8.30e-26

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 108.78  E-value: 8.30e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  98 PYLNKhiSQNNIyMFLGAIGFSLILIFLNYLQYKsFFLKIRNVTAAANKIIEGDyTIDIKENREGDLAKLANSFhklknv 177
Cdd:PRK11100 175 PFIKR--SERRI-LWAGALLLGIALLIGAGVVWW-LNRSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQAL------ 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 178 irKSMHNLLEEKQFLIQTLQDISHQLKTPLSTltvnndI-----LLQGKLN-EQQYHFLHNNEVQISRISFLIHNLLKVS 251
Cdd:PRK11100 244 --ESMRVKLEGKAYVEQYVQTLTHELKSPLAA------IrgaaeLLQEDPPpEDRARFTGNILTQSARLQQLIDRLLELA 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 252 KIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETnEKISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEV 331
Cdd:PRK11100 316 RLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRP-DDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSA 394

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 923062878 332 TNSPIHTEIIIQDFGEGIASEDLPYIFDRFY---KAKNSKKegSIGIGLALAKSIIEAHHGFIKVE 394
Cdd:PRK11100 395 EVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK--STGLGLAFVREVARLHGGEVTLR 458
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 302-407 1.55e-25

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 99.65  E-value: 1.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878   302 DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAK-NSKKEGSIGIGLALA 380
Cdd:smart00387   2 DPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSIV 81

                           90       100
                   ....*....|....*....|....*..
gi 923062878   381 KSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:smart00387  82 KKLVELHGGEISVESEPGGGTTFTITL 108
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 199-407 9.55e-25

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 104.11  E-value: 9.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 199 ISHQLKTPLSTLTVNNDIL---LQGKLN-EQQYHFLHNNEVQISRISFLIHNLLKVSKIDArailFEKENSDIIDTIYEV 274
Cdd:COG4191  149 IAHEINNPLAAILGNAELLrrrLEDEPDpEELREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEA 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 275 IASLNSKLNKKNMNIHLETNEKISLLH-DSIWMQEALLNILKNSIE--HSNDNSSIYIEVTNSPIHTEIIIQDFGEGIAS 351
Cdd:COG4191  225 LELLRPRLKARGIEVELDLPPDLPPVLgDPGQLEQVLLNLLINAIDamEEGEGGRITISTRREGDYVVISVRDNGPGIPP 304

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 923062878 352 EDLPYIFDRFYKAKnSKKEGSiGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG4191  305 EVLERIFEPFFTTK-PVGKGT-GLGLSISYGIVEKHGGRIEVESEPGGGTTFTITL 358
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
115-406 3.20e-24

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 104.08  E-value: 3.20e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 115 AIGFSLILIFLNYLQYKSFFLKIRNVTAAANKIIEGDYTIDIKENREG-DLAKLANSFHKLKNVIrksmhnlleEKQFLI 193
Cdd:PRK09835 191 ASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERI---------EDVFTR 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 194 QT--LQDISHQLKTPLSTLTVNNDILL-QGKLNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDARAILFEKENSDIIDT 270
Cdd:PRK09835 262 QSnfSADIAHEIRTPITNLITQTEIALsQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADE 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 271 IYEVIASLNSKLNKKNMNIHLETNEkISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIA 350
Cdd:PRK09835 342 VGKVFDFFEAWAEERGVELRFVGDP-CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIA 420

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 923062878 351 SEDLPYIFDRFYK---AKNSKKEGSiGIGLALAKSIIEAHHGFIKVESQKHSfTKFTIT 406
Cdd:PRK09835 421 PEHLPRLFDRFYRvdpSRQRKGEGS-GIGLAIVKSIVVAHKGTVAVTSDARG-TRFVIS 477
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
146-399 3.24e-24

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 103.94  E-value: 3.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 146 KIIEGDYTIDIKENREGDLAKLANSFHKLKNVIRKSmhnlleeKQFLIQTLQDISHQLKTPLStltvnndiLLQGKLNEQ 225
Cdd:PRK10549 201 KLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKN-------EQMRRDFMADISHELRTPLA--------VLRGELEAI 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 226 Q-------YHFLHNNEVQISRISFLIHNLLKVSKIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEKIS 298
Cdd:PRK10549 266 QdgvrkftPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSLPDSAT 345

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 299 LLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLA 378
Cdd:PRK10549 346 VFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLG 425

                        250       260
                 ....*....|....*....|...
gi 923062878 379 LA--KSIIEAHHGFIKVEsqkHS 399
Cdd:PRK10549 426 LAicLNIVEAHNGRIIAA---HS 445
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 199-407 1.32e-23

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 102.56  E-value: 1.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 199 ISHQLKTPLSTLTVNNDILLQ---GKLNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDARAILFEKEN-SDIIDtiyEV 274
Cdd:COG4251  289 ASHDLREPLRKISGFSQLLEEdygDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDlNELLE---EV 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 275 IASLNSKLNKKNMNIHLETNEKISLlhDSIWMQEALLNILKNSIEHSNDNSS--IYIEVTNSPIHTEIIIQDFGEGIASE 352
Cdd:COG4251  366 LEDLEPRIEERGAEIEVGPLPTVRG--DPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPE 443

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 923062878 353 DLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG4251  444 YAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTL 498
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 302-407 7.73e-23

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 92.43  E-value: 7.73e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  302 DSIWMQEALLNILKNSIEHSNDNSSIYIEVTnSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSiGIGLALAK 381
Cdd:pfam02518   2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS-EGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGT-GLGLSIVR 79

                          90       100
                  ....*....|....*....|....*.
gi 923062878  382 SIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:pfam02518  80 KLVELLGGTITVESEPGGGTTVTLTL 105
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 199-407 9.77e-23

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 99.66  E-value: 9.77e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 199 ISHQLKTPLSTLTVNNDiLLQGKLNEQQYHFLHNNEVQISRISFLIHNLLKVSKIdaRAILFEKenSDIIDTIYEVIASL 278
Cdd:COG5809  277 IAHEIRNPLTSLKGFIQ-LLKDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKP--QAIKYEP--KDLNTLIEEVIPLL 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 279 NSKLNKKNMNIHLETNEKISLlhdsIWMQEA-----LLNILKNSIEHSNDNSSIYIEVTN-SPIHTEIIIQDFGEGIASE 352
Cdd:COG5809  352 QPQALLKNVQIELELEDDIPD----ILGDENqlkqvFINLLKNAIEAMPEGGNITIETKAeDDDKVVISVTDEGCGIPEE 427

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 923062878 353 DLPYIFDRFYkaknSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG5809  428 RLKKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITL 478
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
199-407 9.24e-22

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 95.68  E-value: 9.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 199 ISHQLKTPLSTLTVNNDILLQGKLNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDArailFEKENSDIIDTIYEVIASL 278
Cdd:COG3852  142 LAHEIRNPLTGIRGAAQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEVLERVLELL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 279 NSKLnKKNMNIHLETNEKI-SLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHT----------EIIIQDFGE 347
Cdd:COG3852  218 RAEA-PKNIRIVRDYDPSLpEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTlgglrprlyvRIEVIDNGP 296

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 348 GIASEDLPYIFDRFYkakNSKKEGSiGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG3852  297 GIPEEILDRIFEPFF---TTKEKGT-GLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYL 352
PRK10490 PRK10490
sensor protein KdpD; Provisional
 196-406 2.33e-21

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 96.64  E-value: 2.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 196 LQDISHQLKTPLSTLTVNNDILLQGKLNEQQYHFLHNNEV--QISRISFLIHNLLKVSKIDARAILFEKENSDIIDTIYE 273
Cdd:PRK10490 668 LAALSHDLRTPLTVLFGQAEILTLDLASEGSPHARQASEIrqQVLNTTRLVNNLLDMARIQSGGFNLRKEWLTLEEVVGS 747

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 274 VIASLNSKLNKKNmnIHLETNEKISLLH-DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASE 352
Cdd:PRK10490 748 ALQMLEPGLSGHP--INLSLPEPLTLIHvDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPG 825

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 923062878 353 DLPYIFDRFYKAKnskKEGSI---GIGLALAKSIIEAHHGFIKVESQKHSFTKFTIT 406
Cdd:PRK10490 826 QEQLIFDKFARGN---KESAIpgvGLGLAICRAIVEVHGGTIWAENRPEGGACFRVT 879
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 199-407 6.97e-21

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 94.41  E-value: 6.97e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 199 ISHQLKTPLST----LTvnndiLLQGKLNEQQyHFLHNNEVQISRISFLIHNLLKVSKIDAraILFEKENsdIIDTIYEV 274
Cdd:COG5805  294 IAHEIRNPLTSikgfLQ-----LLQPGIEDKE-EYFDIMLSELDRIESIISEFLALAKPQA--VNKEKEN--INELIQDV 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 275 IASLNSKLNKKNMNIHLETNEKISLLH-DSIWMQEALLNILKNSIEHSNDNSSIYI--EVTNSPIHteIIIQDFGEGIAS 351
Cdd:COG5805  364 VTLLETEAILHNIQIRLELLDEDPFIYcDENQIKQVFINLIKNAIEAMPNGGTITIhtEEEDNSVI--IRVIDEGIGIPE 441

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 923062878 352 EDLPYIFDRFYkaknSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG5805  442 ERLKKLGEPFF----TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITL 493
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
137-394 2.35e-20

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 92.69  E-value: 2.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 137 IRNVTAAANKIIEGDYTIDIK-ENREGDLAKLANSFhklkNVIRKSMHNLLEEKQFLiqtLQDISHQLKTPLSTLTVNND 215
Cdd:PRK09470 194 ARKLKNAADEVAQGNLRQHPElETGPQEFRQAGASF----NQMVTALERMMTSQQRL---LSDISHELRTPLTRLQLATA 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 216 ILL--QGKLNEqqyhfLHNNEVQISRISFLIHNLLKVSKIDARAILfEKENSDIIDTIYEVIAslNSKLNKKNMNIHLET 293
Cdd:PRK09470 267 LLRrrQGESKE-----LERIETEAQRLDSMINDLLVLSRNQQKNHL-ERETFKANSLWSEVLE--DAKFEAEQMGKSLTV 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 294 N---EKISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHteIIIQDFGEGIASEDLPYIFDRFYKAKNS--K 368
Cdd:PRK09470 339 SappGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLT--ITVDDDGPGVPEEEREQIFRPFYRVDEArdR 416

                        250       260
                 ....*....|....*....|....*.
gi 923062878 369 KEGSIGIGLALAKSIIEAHHGFIKVE 394
Cdd:PRK09470 417 ESGGTGLGLAIVENAIQQHRGWVKAE 442
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
198-407 2.49e-19

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 89.30  E-value: 2.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 198 DISHQLKTPLSTLT----VNNDILLQGKLNEQQyhfLHNNEVQISRISFLIHNLLKVSKIDARAILFEKENSDIiDTIYE 273
Cdd:PRK11006 210 NVSHELRTPLTVLQgyleMMQDQPLEGALREKA---LHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDV-PMMLR 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 274 VIASLNSKLNKKNMNIHLETNEKISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASED 353
Cdd:PRK11006 286 VLEREAQTLSQGKHTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDNGPGIAPEH 365

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 923062878 354 LPYIFDRFY---KAKnSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:PRK11006 366 IPRLTERFYrvdKAR-SRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVL 421
PRK09303 PRK09303
histidine kinase;
177-406 1.69e-18

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 86.54  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 177 VIRKSMHNLLEEKQFLIQTLQDISHQLKTPLS-------TLTVNN---DILLQGKLNEQQYHFLHNnevQISRISFLIHN 246
Cdd:PRK09303 136 VLRQENETLLEQLKFKDRVLAMLAHDLRTPLTaaslaleTLELGQideDTELKPALIEQLQDQARR---QLEEIERLITD 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 247 LLKVSKIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEKISLLH-DSIWMQEALLNILKNSIEHSNDNS 325
Cdd:PRK09303 213 LLEVGRTRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYaDQERIRQVLLNLLDNAIKYTPEGG 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 326 SIYIEV---TNSPIhtEIIIQDFGEGIASEDLPYIF-DRFYKAKNSKKEGsIGIGLALAKSIIEAHHGFIKVESQKHSFT 401
Cdd:PRK09303 293 TITLSMlhrTTQKV--QVSICDTGPGIPEEEQERIFeDRVRLPRDEGTEG-YGIGLSVCRRIVRVHYGQIWVDSEPGQGS 369


                 ....*
gi 923062878 402 KFTIT 406
Cdd:PRK09303 370 CFHFT 374
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-407 6.41e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 75.78  E-value: 6.41e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 302 DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEG-SIGIGLALA 380
Cdd:cd16948    2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQeSTGMGLYLV 81

                         90       100
                 ....*....|....*....|....*..
gi 923062878 381 KSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:cd16948   82 KKLCDKLGHKIDVESEVGEGTTFTITF 108
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 310-405 1.13e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 75.15  E-value: 1.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 310 LLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKnSKKEGSiGIGLALAKSIIEAHHG 389
Cdd:cd16943    8 LLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTK-PVGEGT-GLGLSLSYRIIQKHGG 85

                         90
                 ....*....|....*.
gi 923062878 390 FIKVESQKHSFTKFTI 405
Cdd:cd16943   86 TIRVASVPGGGTRFTI 101
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 309-397 2.22e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 74.28  E-value: 2.22e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 309 ALLNILKNSIEHSNDNSSIYIEVTNSPIHteIIIQDFGEGIASEDLPYIFDRFYK---AKNSKKEGSiGIGLALAKSIIE 385
Cdd:cd16949    4 ALENVLRNALRYSPSKILLDISQDGDQWT--ITITDDGPGVPEDQLEQIFLPFYRvdsARDRESGGT-GLGLAIAERAIE 80

                         90
                 ....*....|..
gi 923062878 386 AHHGFIKVESQK 397
Cdd:cd16949   81 QHGGKIKASNRK 92
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
199-407 4.44e-16

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 80.01  E-value: 4.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 199 ISHQLKTPLSTLTVNNDILLQGKLNEQQYHFLhnNEV--QISRISFLIHNLLKVSKidARAILFEKENSDIIdtIYEVIA 276
Cdd:PRK11360 397 VAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYL--SVVlrEVDRLNKVIDQLLEFSR--PRESQWQPVSLNAL--VEEVLQ 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 277 SLNSKLNKKNMNIHLETNEKISLlhdsIW-----MQEALLNILKNSIEHSNDNSSIYIEVTN-SPIHTEIIIQDFGEGIA 350
Cdd:PRK11360 471 LFQTAGVQARVDFETELDNELPP----IWadpelLKQVLLNILINAVQAISARGKIRIRTWQySDGQVAVSIEDNGCGID 546

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 923062878 351 SEDLPYIFDRFYKAKNSkkeGSiGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:PRK11360 547 PELLKKIFDPFFTTKAK---GT-GLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-406 2.94e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 71.26  E-value: 2.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIE 385
Cdd:cd16923    1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80

                         90       100
                 ....*....|....*....|..
gi 923062878 386 AHHGFIKVESQ-KHSFTKFTIT 406
Cdd:cd16923   81 LHGGSASAEYDdNHDLFKVRLP 102
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-407 5.81e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 70.57  E-value: 5.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKE--GSIGIGLALAKSI 383
Cdd:cd16946    5 LQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRasGGSGLGLAICHNI 84

                         90       100
                 ....*....|....*....|....
gi 923062878 384 IEAHHGFIKVESQKHSFTKFTITF 407
Cdd:cd16946   85 ALAHGGTISAEHSPLGGLRLVLTL 108
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
266-405 3.31e-14

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 74.05  E-value: 3.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 266 DIIDTIYEVIASLNSKLNKKNMNIHLETNEKISLLH-DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQD 344
Cdd:PRK10364 308 DLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQaDPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTD 387

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 923062878 345 FGEGIASEDLPYIFDRFYKAKNskkEGSiGIGLALAKSIIEAHHGFIKVESQKHSFTKFTI 405
Cdd:PRK10364 388 SGKGIAADQLEAIFTPYFTTKA---EGT-GLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-406 5.74e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 67.42  E-value: 5.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIE---HSNDNSSIyIEVTNSPI---HTEIIIQDFGEGIASEDLPYIFDRFYkakNSKKEGsIGIGLAL 379
Cdd:cd16920    1 IQQVLINLVRNGIEamsEGGCERRE-LTIRTSPAddrAVTISVKDTGPGIAEEVAGQLFDPFY---TTKSEG-LGMGLSI 75

                         90       100
                 ....*....|....*....|....*..
gi 923062878 380 AKSIIEAHHGFIKVESQKHSFTKFTIT 406
Cdd:cd16920   76 CRSIIEAHGGRLSVESPAGGGATFQFT 102
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-407 1.24e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 66.66  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 302 DSIWMQEALLNILKNSIEHSNDNSSIYIEVtNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSiGIGLALAK 381
Cdd:cd16940   10 DALLLFLLLRNLVDNAVRYSPQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQNYGGS-GLGLSIVK 87

                         90       100
                 ....*....|....*....|....*.
gi 923062878 382 SIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:cd16940   88 RIVELHGGQIFLGNAQGGGLEAWVRL 113
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 278-407 1.30e-12

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 68.72  E-value: 1.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 278 LNSKLNK-KNMNIHLETNEKISLLHDSIWMQE---ALLNILKNSIEHSNDNSS----IYIEVTNSPIHTEIIIQDFGEGI 349
Cdd:COG3290  250 LLGKAARaRERGIDLTIDIDSDLPDLPLSDTDlvtILGNLLDNAIEAVEKLPEeerrVELSIRDDGDELVIEVEDSGPGI 329

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 923062878 350 ASEDLPYIFDRFYkakNSKKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:COG3290  330 PEELLEKIFERGF---STKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-406 1.09e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 61.19  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTE--IIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSI 383
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEwtFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80

                         90       100
                 ....*....|....*....|...
gi 923062878 384 IEAHHGFIKVESQKHSFTKFTIT 406
Cdd:cd16921   81 IERHGGRIWLESEPGEGTTFYFT 103
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-406 1.63e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 61.38  E-value: 1.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKA---KNSKKEGSiGIGLALAKS 382
Cdd:cd16947   21 LQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLedsRNSAKQGN-GLGLTITKR 99

                         90       100
                 ....*....|....*....|....
gi 923062878 383 IIEAHHGFIKVESQKHSFTKFTIT 406
Cdd:cd16947  100 LAESMGGSIYVNSKPYEKTVFTVT 123
PRK10337 PRK10337
sensor protein QseC; Provisional
 185-388 1.90e-11

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 65.44  E-value: 1.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 185 LLEEKQFLiqtlQDISHQLKTPLSTLTVNNDIL-LQGKLNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDARAILFEKE 263
Cdd:PRK10337 234 MVRERRFT----SDAAHELRSPLAALKVQTEVAqLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVA 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 264 NSDIIDTIYEVIASLNSKLNKKNMNIHLETNEkisllHDSIWMQEALL------NILKNSIEHSNDNSSIYIEVTNSPIH 337
Cdd:PRK10337 310 EIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNA-----HPVIRTGQPLLlsllvrNLLDNAIRYSPQGSVVDVTLNARNFT 384

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 923062878 338 teiiIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSiGIGLALAKSIIEAHH 388
Cdd:PRK10337 385 ----VRDNGPGVTPEALARIGERFYRPPGQEATGS-GLGLSIVRRIAKLHG 430
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-407 6.48e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 59.14  E-value: 6.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYK--AKNSKKEGSIGIGLALAKSI 383
Cdd:cd16952    1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRvdIERCRNTGGTGLGLAIVKHV 80

                         90       100
                 ....*....|....*....|....
gi 923062878 384 IEAHHGFIKVESQKHSFTKFTITF 407
Cdd:cd16952   81 MSRHDARLLIASELGKGSRFTCLF 104
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 306-406 8.69e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 58.66  E-value: 8.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNDNS-SIYIEV---TNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNS--KKEGSIGIGLAL 379
Cdd:cd16922    1 LRQILLNLLGNAIKFTEEGEvTLRVSLeeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSttRKYGGTGLGLAI 80

                         90       100
                 ....*....|....*....|....*..
gi 923062878 380 AKSIIEAHHGFIKVESQKHSFTKFTIT 406
Cdd:cd16922   81 SKKLVELMGGDISVESEPGQGSTFTFT 107
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 312-406 4.02e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 56.53  E-value: 4.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 312 NILKNSIEHSND----NSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYkakNSKKEGSIGIGLALAKSIIEAH 387
Cdd:cd16915    7 NLIDNALDALAAtgapNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV---STKGQGERGIGLALVRQSVERL 83

                         90
                 ....*....|....*....
gi 923062878 388 HGFIKVESQKHSFTKFTIT 406
Cdd:cd16915   84 GGSITVESEPGGGTTFSIR 102
PRK15347 PRK15347
two component system sensor kinase;
158-395 5.77e-10

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 61.20  E-value: 5.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 158 ENREGDLAKLANSFHKLKNVIRKSMHNL----------LEE-KQFLIQT-------LQDISHQLKTPLSTLTVNNDILLQ 219
Cdd:PRK15347 346 ENRLDELGSIAKAYNQLLDTLNEQYDTLenkvaertqaLAEaKQRAEQAnkrksehLTTISHEIRTPLNGVLGALELLQN 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 220 GKLNEQQyHFLHNNEVQISR-ISFLIHNLLKVSKIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEKI- 297
Cdd:PRK15347 426 TPLTAEQ-MDLADTARQCTLsLLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVp 504

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 298 -SLLHDSIWMQEALLNILKNSIEHSNDnSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKeGSiGIG 376
Cdd:PRK15347 505 lYLHLDSLRLRQILVNLLGNAVKFTET-GGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ-GT-GLG 581

                        250
                 ....*....|....*....
gi 923062878 377 LALAKSIIEAHHGFIKVES 395
Cdd:PRK15347 582 LTIASSLAKMMGGELTLFS 600
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-393 8.23e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 55.93  E-value: 8.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 302 DSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFY---KAKNSKKegSIGIGLA 378
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYslpRPHSGQK--STGLGLA 78

                         90
                 ....*....|....*
gi 923062878 379 LAKSIIEAHHGFIKV 393
Cdd:cd16945   79 FVQEVAQLHGGRITL 93
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 100-395 1.26e-09

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 60.09  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 100 LNKHISQNNIyMFLGAIGFSLIL-IFLNYLQYKSFFLKIRNVTAAA-NKIIEGDYTIDIKENREGDLAKLANSFHK-LKN 176
Cdd:COG4192  317 TAQLVQQSGI-LLLAIALLSLLLaVLINYFYVRRRLVKRLNALSDAmAAIAAGDLDVPIPVDGNDEIGRIARLLRVfRDQ 395

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 177 VIRKSmHNLLEEKQ--------------FLIQ---------TLQDISHQLKTPLSTLTVNNDIL---LQGKLNEQQYHFL 230
Cdd:COG4192  396 AIEKT-QELETEIEerkrieknlrqtqdELIQaakmavvgqTMTSLAHELNQPLNAMSMYLFSAkkaLEQENYAQLPTSL 474

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 231 HNNEVQISRISFLIHNLLKVSKIDARAILFekenSDIIDTIYEVIASLNSKLNKKNMNIHLETNEKIslLHDSIWMQEAL 310
Cdd:COG4192  475 DKIEGLIERMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQAWELVESRAKPQQITLHIPDDLMV--QGDQVLLEQVL 548

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 311 LNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIAseDLPYIFDRFYkaknSKKEGSIGIGLALAKSIIEAHHGF 390
Cdd:COG4192  549 VNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFT----TTKEVGLGLGLSICRSIMQQFGGD 622


                 ....*
gi 923062878 391 IKVES 395
Cdd:COG4192  623 LYLAS 627
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 194-255 1.60e-09

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 53.72  E-value: 1.60e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 923062878   194 QTLQDISHQLKTPLSTLTVNNDILLQGKLNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDA 255
Cdd:smart00388   4 EFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 194-255 3.36e-09

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 52.60  E-value: 3.36e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 923062878  194 QTLQDISHQLKTPLSTLTVNNDILLQGKLNEQQYHFLHNNEVQISRISFLIHNLLKVSKIDA 255
Cdd:pfam00512   4 EFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 179-406 7.49e-09

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 57.64  E-value: 7.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 179 RKSMHNLLE----EKQFLIQTlqdISHQLKTPLSTLTVNNDILLQGKLNEQQYHFLhnNEVQISRISF--LIHNLLKVSK 252
Cdd:PRK11091 269 RKRYQDALEkasrDKTTFIST---ISHELRTPLNGIVGLSRILLDTELTAEQRKYL--KTIHVSAITLgnIFNDIIDMDK 343

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 253 IDARAILFEKENSDIIDTIYEV--IASL--NSKLNKKNMNIHLETNEKISLlhDSIWMQEALLNILKNSIEHSnDNSSIY 328
Cdd:PRK11091 344 MERRKLQLDNQPIDFTDFLADLenLSGLqaEQKGLRFDLEPLLPLPHKVIT--DGTRLRQILWNLISNAVKFT-QQGGVT 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 329 IEV---TNSPIHTEiiIQDFGEGIASEDLPYIFDRFYKAKNSKKE----GSiGIGLALAKSIIEAHHGFIKVESQKHSFT 401
Cdd:PRK11091 421 VRVryeEGDMLTFE--VEDSGIGIPEDELDKIFAMYYQVKDSHGGkpatGT-GIGLAVSKRLAQAMGGDITVTSEEGKGS 497


                 ....*
gi 923062878 402 KFTIT 406
Cdd:PRK11091 498 CFTLT 502
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-405 9.43e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 52.46  E-value: 9.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIE--HSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKegSIGIGLALAKSI 383
Cdd:cd16976    1 IQQVLMNLLQNALDamGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK--GTGLGLSISYGI 78

                         90       100
                 ....*....|....*....|..
gi 923062878 384 IEAHHGFIKVESQKHSFTKFTI 405
Cdd:cd16976   79 VEEHGGRLSVANEEGAGARFTF 100
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
163-406 9.74e-09

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 57.44  E-value: 9.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  163 DLAKLANSFHKLKNVIRKSMHNLLEEKQFLiqtlQDISHQLKTPLSTLTVNNDILLQGKLN-EQQYHFLHNNEVQISRIS 241
Cdd:PRK09959  687 DITETRDLIHALEVERNKAINATVAKSQFL----ATMSHEIRTPISSIMGFLELLSGSGLSkEQRVEAISLAYATGQSLL 762

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  242 FLIHNLLKVSKIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETN--EKISLLHDSIWMQEALLNILKNSIE 319
Cdd:PRK09959  763 GLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTfpDHYLVKIDPQAFKQVLSNLLSNALK 842

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  320 HSNDNSsiyIEVTNSPIHTE-------IIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIEAHHGFIK 392
Cdd:PRK09959  843 FTTEGA---VKITTSLGHIDdnhavikMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLS 919

                         250
                  ....*....|....
gi 923062878  393 VESQKHSFTKFTIT 406
Cdd:PRK09959  920 LESHPGIGTTFTIT 933
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 277-407 1.24e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 53.02  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 277 SLNSKLNK----KNMNIHLETNEKISLLHDSIWMQEALLNILKNSIEHSNDnssiYIEVT--NSPIHTEIIIQDFGEGIA 350
Cdd:cd16954    5 SLCSALNKvyqrKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLE----FVEVTarQTDGGLHLIVDDDGPGVP 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 923062878 351 SEDLPYIFDRFYKAkNSKKEGSiGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:cd16954   81 ESQRSKIFQRGQRL-DEQRPGQ-GLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
envZ PRK09467
osmolarity sensor protein; Provisional
 263-393 2.01e-08

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 56.07  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 263 ENSDIIDTIYEVIASLNSKlnKKNMNIHLETNEKISLLHdSIWMQEALLNILKNSIEHSNDnssiYIEVTNSpiHTE--- 339
Cdd:PRK09467 292 EMADLNALLGEVIAAESGY--EREIETALQPGPIEVPMN-PIAIKRALANLVVNAARYGNG----WIKVSSG--TEGkra 362

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 923062878 340 -IIIQDFGEGIASEDLPYIFDRFY---KAKNSkkEGSiGIGLALAKSIIEAHHGFIKV 393
Cdd:PRK09467 363 wFQVEDDGPGIPPEQLKHLFQPFTrgdSARGS--SGT-GLGLAIVKRIVDQHNGKVEL 417
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
195-395 2.45e-08

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 55.79  E-value: 2.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 195 TLQDISHQLKTPLSTLTVNNDILLQGK-LNEQQYH--FLHnnevQISRISFLIHNLLKVSKIDARAILFEKEnsdiIDTI 271
Cdd:PRK10815 269 TLTDLTHSLKTPLAVLQSTLRSLRSGKqMSVEQAEpiMLE----QISRISQQIGYYLHRASMRSEHNLLSRE----LHSV 340

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 272 YEVIASLNSKLNK----KNMNIHLETNEKISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPIHteIIIQDFGE 347
Cdd:PRK10815 341 APLLDNLTSALNKvyqrKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHLH--IVVEDDGP 418

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 923062878 348 GIASEDLPYIFDRFYKAkNSKKEGSiGIGLALAKSIIEAHHGFIKVES 395
Cdd:PRK10815 419 GIPESKRELIFDRGQRA-DTLRPGQ-GLGLSVAREITEQYEGKISAGD 464
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-391 4.27e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 50.91  E-value: 4.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNdnSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIE 385
Cdd:cd16950    1 LKRVLSNLVDNALRYGG--GWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78


                 ....*.
gi 923062878 386 AHHGFI 391
Cdd:cd16950   79 AHGGSL 84
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
1-394 5.95e-08

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 54.73  E-value: 5.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878   1 MINREIKINILTLALISFLFIIYQVITVHILYDHLKNDYITIWSEITGKLITQNPENEYEIIQALTNDTANKKDYSSDGE 80
Cdd:COG2770  104 LLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  81 MLLNQYGLSAELDSRLFPYLNKHISQNNIYMFLGAIGFSLILIFLNYLQYKSFFLKIRNVTAAANKIIEGDYTIDIKENR 160
Cdd:COG2770  184 AALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSR 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 161 EGDLAKLANSFHKLKNVIRKSMHNLLEEKQFLIQTLQDISHQLKTPLSTLTVNNDILLQGKLNEQQYHFLHNNEVQISRI 240
Cdd:COG2770  264 KDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLL 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 241 SFLIHNLLKVSKIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEKISLLHDSIWMQEALLNILKNSIEH 320
Cdd:COG2770  344 LLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLA 423

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 923062878 321 SNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIEAHHGFIKVE 394
Cdd:COG2770  424 LAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEE 497
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-396 6.22e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 50.48  E-value: 6.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNDN-------SSIYIEVT-NSPIH---TEIIIQDFGEGIASEDLPYIFDRFYkaknSKKEGSIG 374
Cdd:cd16918    1 LIQVFLNLVRNAAQALAGSggeiilrTRTQRQVTlGHPRHrlaLRVSVIDNGPGIPPDLQDTIFYPMV----SGRENGTG 76

                         90       100
                 ....*....|....*....|..
gi 923062878 375 IGLALAKSIIEAHHGFIKVESQ 396
Cdd:cd16918   77 LGLAIAQNIVSQHGGVIECDSQ 98
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 306-406 6.79e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 50.12  E-value: 6.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNdnSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKE--GSIGIGLALAKSI 383
Cdd:cd16939    1 MARALDNLLRNALRYAH--RTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRatGGFGLGLAIVHRV 78

                         90       100
                 ....*....|....*....|...
gi 923062878 384 IEAHHGFIKVESQKHSFTKFTIT 406
Cdd:cd16939   79 ALWHGGHVECDDSELGGACFRLT 101
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 302-396 1.51e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 49.46  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 302 DSIWMQEALLNILKNSIEHSNDNSSIYIEV-----TNSPIHTEIIIQDFGEGIASEDL-----PYIFDRfykaknskkEG 371
Cdd:cd16944    1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVrirveADQDGRIVLIVCDNGKGFPREMRhratePYVTTR---------PK 71

                         90       100
                 ....*....|....*....|....*
gi 923062878 372 SIGIGLALAKSIIEAHHGFIKVESQ 396
Cdd:cd16944   72 GTGLGLAIVKKIMEEHGGRISLSNR 96
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 308-394 1.92e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 49.11  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 308 EALLNILKNSIEHS-NDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFY--KAKNSKKEGSIGIGLALAKSII 384
Cdd:cd16953    3 QVLRNLIGNAISFSpPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYteRPANEAFGQHSGLGLSISRQII 82

                         90
                 ....*....|
gi 923062878 385 EAHHGFIKVE 394
Cdd:cd16953   83 EAHGGISVAE 92
PRK10604 PRK10604
sensor protein RstB; Provisional
 161-395 5.93e-07

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 51.14  E-value: 5.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 161 EGDLAKL-----ANSFHKLK---NVIRKSMHNLLEEKQFLIQTlqdISHQLKTPLSTLTVNNDILLQGKLNEQQyhflhN 232
Cdd:PRK10604 176 DGHLAERihfdeGSSLERLGvafNQMADNINALIASKKQLIDG---IAHELRTPLVRLRYRLEMSDNLSAAESQ-----A 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 233 NEVQISRISFLIHNLLKVSKIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEKISLLhDSIWMQEALLN 312
Cdd:PRK10604 248 LNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGAL-DMRLMERVLDN 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 313 ILKNSIEHSNDNSSIYIEVTNSpiHTEIIIQDFGEGIASEDLPYIFDRFYKAKNS--KKEGSIGIGLALAKSIIEAHHGF 390
Cdd:PRK10604 327 LLNNALRYAHSRVRVSLLLDGN--QACLIVEDDGPGIPPEERERVFEPFVRLDPSrdRATGGCGLGLAIVHSIALAMGGS 404


                 ....*
gi 923062878 391 IKVES 395
Cdd:PRK10604 405 VNCDE 409
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
292-405 5.94e-07

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 51.60  E-value: 5.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 292 ETNEKISLLHDSIWMQEALLNILKNSIEHSNDNSSIYIEVTNSPI---------------HTEIIIQDFGEGIASEDLPY 356
Cdd:PRK13837 547 QDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKLrapkvlshgvlppgrYVLLRVSDTGAGIDEAVLPH 626

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 923062878 357 IFDRFYKAKNskkeGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTI 405
Cdd:PRK13837 627 IFEPFFTTRA----GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDV 671
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 274-405 6.47e-07

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 51.45  E-value: 6.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 274 VIAS-LNSKLNK-KNMNIHLETNEKiSLLHDSIWMQEA--LLNILKNSIEHSND--------NSSIYIEVTNSPIHteII 341
Cdd:PRK11086 395 VIAGfLLGKISRaRELGITLIISED-SQLPDSGDEDQVheLITILGNLIENALEavggeeggEISVSLHYRNGWLH--CE 471

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 923062878 342 IQDFGEGIASEDLPYIFDRFYKAKNSKKegsiGIGLALAKSIIEAHHGFIKVESQKHSFTKFTI 405
Cdd:PRK11086 472 VSDDGPGIAPDEIDAIFDKGYSTKGSNR----GVGLYLVKQSVENLGGSIAVESEPGVGTQFFV 531
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
1-407 8.26e-07

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 50.79  E-value: 8.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878   1 MINREIKINILTLALISFLFIIYQVITVHILYDHLKNDYITIWSEITGKLITQNPENEYEIIQALTNDTANKKDYSSDGE 80
Cdd:COG2972   47 LILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  81 MLLNQYGLSAELDSRLFPY--LNKHISQNNIYMFLGAIGFSLILIFLNYLQYKSFFLKIRNVTAAANKIIEGDYTIdIKE 158
Cdd:COG2972  127 IILLLLSLLGWTLVSLIPKseLFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEV 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 159 NREGDLAKLANSFHKLKNVIRKSMHNLLEEKQFLIQTlqdishQLKtplstltvnndiLLQGKLNEqqyHFLHNNevqIS 238
Cdd:COG2972  206 SGNDEIGILARSFNEMVERIKELIEEVYELELEKKEA------ELK------------ALQAQINP---HFLFNT---LN 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 239 RISFLIHnllkvskidarailfEKENSDIIDTIYEVIASLNSKLNKKNMNIHLEtnEKISLLHD---------------S 303
Cdd:COG2972  262 SIRWLAE---------------LEDPEEAEEMLEALSKLLRYSLSKGDELVTLE--EELELIKSyleiqklrfgdrlevE 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 304 IWMQEALLN----------ILKNSIEH----SNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFykaknSKK 369
Cdd:COG2972  325 IEIDEELLDllipklilqpLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-----SSK 399

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 923062878 370 EGSIGIGLALAKSIIEAHHG---FIKVESQKHSFTKFTITF 407
Cdd:COG2972  400 GEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRI 440
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 309-407 1.08e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 47.07  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 309 ALLNILKNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGS-IGIGLALAKSIIEAH 387
Cdd:cd16975    8 ALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIAKNLVEKH 87

                         90       100
                 ....*....|....*....|
gi 923062878 388 HGFIKVESQKHSFTKFTITF 407
Cdd:cd16975   88 GGSLIIENSQKGGAEVTVKI 107
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 306-405 1.38e-06

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 46.72  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 306 MQEALLNILKNSIEHSNDNSSIY--IEVTNSPiHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSK--KEGSIGIGLALAK 381
Cdd:cd16925    5 YERVVLNLLSNAFKFTPDGGRIRciLEKFRLN-RFLLTVSDSGPGIPPNLREEIFERFRQGDGSStrAHGGTGLGLSIVK 83

                         90       100
                 ....*....|....*....|....
gi 923062878 382 SIIEAHHGFIKVESQKHSFTKFTI 405
Cdd:cd16925   84 EFVELHGGTVTVSDAPGGGALFQV 107
glnL PRK11073
nitrogen regulation protein NR(II);
299-405 1.89e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 49.31  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 299 LLHDSIWMQEALLNILKNSIEH-SNDNSSIYIE---VTNSPIH-------TEIIIQDFGEGIASEdlpyIFDRFYKAKNS 367
Cdd:PRK11073 231 LAHDPDQIEQVLLNIVRNALQAlGPEGGTITLRtrtAFQLTLHgeryrlaARIDIEDNGPGIPPH----LQDTLFYPMVS 306

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 923062878 368 KKEGSIGIGLALAKSIIEAHHGFIKVES-QKHsfTKFTI 405
Cdd:PRK11073 307 GREGGTGLGLSIARNLIDQHSGKIEFTSwPGH--TEFSV 343
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
183-389 3.06e-06

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 48.81  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 183 HNLLEEKQFLiqtlQDISHQLKTPLStltvnnDILLQGKLNEQQyhflHNNEVQ--ISRISFLIHN---LLKVSKIDARa 257
Cdd:PRK10755 132 STLDQERLFT----ADVAHELRTPLA------GIRLHLELLEKQ----HHIDVAplIARLDQMMHTveqLLQLARAGQS- 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 258 ilFEKENSDIIDTIYEVIASLNSKLN----KKNMNIHLETNEKISLLH-DSIWMQEALLNILKNSIEHSNDNSSIYIEVT 332
Cdd:PRK10755 197 --FSSGHYQTVKLLEDVILPSQDELSemleQRQQTLLLPESAADITVQgDATLLRLLLRNLVENAHRYSPEGSTITIKLS 274

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 333 NSPIHTEIIIQDFGEGI---ASEDLPYIFDRFykaknSKKEGSIGIGLALAKSIIEAHHG 389
Cdd:PRK10755 275 QEDGGAVLAVEDEGPGIdesKCGELSKAFVRM-----DSRYGGIGLGLSIVSRITQLHHG 329
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 4-389 1.50e-05

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 46.80  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878   4 REIKINILTLALISFLFIIYQVITVHILYDHLKNDYITIWSEITGKLITQNPENEYEIIQALTNDTANKKDYSSDGEMLL 83
Cdd:COG3850   12 LRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  84 NQYGLSAELDSRLFPYLNKHISQNNIYMFLGAIGFSLIL-IFLNYLQYKSFFLKIRNVTAAANKIIEGDYTIDIKENREG 162
Cdd:COG3850   92 LLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLaLLLAYLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRD 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 163 DLAKLANSFHKLKNVIRKSmHNLLEEKQFLIQTLQDISHQLKTPLSTLTVNNDILLQGKLNEQQYHFLHNNEVQISRISF 242
Cdd:COG3850  172 ELGTLARAFNRMADELQEL-YAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAE 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 243 LIHNLLKVSKIDARAILFEKENSDIIDTIYEVIASLNSKLNKKNMNIHLETNEKISLLHDSIWMQEALLNILKNSIEHSN 322
Cdd:COG3850  251 SELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLL 330

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 923062878 323 DNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIFDRFYKAKNSKKEGSIGIGLALAKSIIEAHHG 389
Cdd:COG3850  331 IALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAA 397
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 190-252 1.91e-05

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 42.20  E-value: 1.91e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 923062878 190 QFLIQTLQDISHQLKTPLSTLTVNNDILLQGKL-NEQQYHFLHNNEVQISRISFLIHNLLKVSK 252
Cdd:cd00082    2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLdDEEQREYLERIREEAERLLRLINDLLDLSR 65
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 196-407 3.07e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 46.38  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 196 LQDISHQLKTPLstltvNNDI-----LLQGKLNEQQYHFLH------NNEVQIsrisflIHNLLKVSKIDARAILFEKEN 264
Cdd:PRK11107 297 LANMSHELRTPL-----NGVIgftrqTLKTPLTPTQRDYLQtiersaNNLLAI------INDILDFSKLEAGKLVLENIP 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 265 SDIIDTIYEVIASLNSKLNKKNMNIHLETNEKI--SLLHDSIWMQEALLNILKNSIEHSnDNSSIYIEV-----TNSPIH 337
Cdd:PRK11107 366 FSLRETLDEVVTLLAHSAHEKGLELTLNIDPDVpdNVIGDPLRLQQIITNLVGNAIKFT-ESGNIDILVelralSNTKVQ 444

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 923062878 338 TEIIIQDFGEGIASEDLPYIFDRFYKAKNS--KKEGSIGIGLALAKSIIEAHHGFIKVESQKHSFTKFTITF 407
Cdd:PRK11107 445 LEVQIRDTGIGISERQQSQLFQAFRQADASisRRHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHL 516
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
196-405 3.16e-05

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 46.12  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 196 LQDISHQLKTPLSTLTVNNDiLLQGKLNEQQYHFL----HNNEVQISRIsflIHNLLKVSKIDARAILFEKENSDIIDTI 271
Cdd:PRK10841 451 LATVSHELRTPLYGIIGNLD-LLQTKELPKGVDRLvtamNNSSSLLLKI---ISDILDFSKIESEQLKIEPREFSPREVI 526

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 272 YEVIASLNSKLNKKNMNIH--LETNEKISLLHDSIWMQEALLNILKNSIEHSnDNSSIYIEVTNSPIHTEIIIQDFGEGI 349
Cdd:PRK10841 527 NHITANYLPLVVKKRLGLYcfIEPDVPVALNGDPMRLQQVISNLLSNAIKFT-DTGCIVLHVRVDGDYLSFRVRDTGVGI 605

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 923062878 350 ASEDLPYIFDRFYKAKNSKK---EGSiGIGLALAKSIIEAHHGFIKVESQKHSFTKFTI 405
Cdd:PRK10841 606 PAKEVVRLFDPFFQVGTGVQrnfQGT-GLGLAICEKLINMMDGDISVDSEPGMGSQFTI 663
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 137-171 2.89e-04

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 38.19  E-value: 2.89e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 923062878 137 IRNVTAAANKIIEGDYTIDIKENREGDLAKLANSF 171
Cdd:cd06225    4 LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAF 38
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
10-203 4.96e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 42.31  E-value: 4.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  10 ILTLALISFLFIIYQVITVHILYDHLKNDYITIWSEITGKLITQNPENEYEIIQALTNDTANKKDYSSDGEMLLNQYGLS 89
Cdd:COG0840   83 ALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878  90 AELDSRLFPYLNKHISQNNIYMFLGAIGFSLILIFLNYLQYKSFFLKIRNVTAAANKIIEGDYTIDIKENREGDLAKLAN 169
Cdd:COG0840  163 LAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLAD 242

                        170       180       190
                 ....*....|....*....|....*....|....
gi 923062878 170 SFhklkNVIRKSMHNLLEEKQFLIQTLQDISHQL 203
Cdd:COG0840  243 AF----NRMIENLRELVGQVRESAEQVASASEEL 272
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
316-383 2.18e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 37.97  E-value: 2.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 923062878 316 NSIEHSNDNSS---IYIEVTNSPIHTEIIIQDFGEGIASEDLPyifdrfyKAKNSKKEGsiGIGLALAKSI 383
Cdd:COG2172   45 NAVRHAYGGDPdgpVEVELELDPDGLEIEVRDEGPGFDPEDLP-------DPYSTLAEG--GRGLFLIRRL 106
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
254-407 2.47e-03

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 39.22  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 254 DARAILFE-----KENSDIIDTIYEVIASLNSKLNkknMNIHLETNEKISLLHDSIWM------QEALLNILKnsieHSN 322
Cdd:COG4585  107 ELRRLVRGlrppaLDDLGLAAALEELAERLLRAAG---IRVELDVDGDPDRLPPEVELalyrivQEALTNALK----HAG 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 323 DnSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPyifdrfykaknskkegSIGIGLALAKSIIEAHHGFIKVESQKHSFTK 402
Cdd:COG4585  180 A-TRVTVTLEVDDGELTLTVRDDGVGFDPEAAP----------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTR 242


                 ....*
gi 923062878 403 FTITF 407
Cdd:COG4585  243 VRATL 247
PRK14868 PRK14868
DNA topoisomerase VI subunit B; Provisional
 307-382 3.34e-03

DNA topoisomerase VI subunit B; Provisional


Pssm-ID: 237842 [Multi-domain]  Cd Length: 795  Bit Score: 39.78  E-value: 3.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923062878 307 QEALLNILkNSIEHSNDNSSIYIEVTNSPIHTEIIIQDFGEGIASEDLPYIF------DRFYKAKNSKKEGSIGIGLALA 380
Cdd:PRK14868  52 KEAVDNAL-DATEEAGILPDIYVEIEEVGDYYRLVVEDNGPGITKEQIPKVFgkllygSRFHAREQSRGQQGIGISAAVL 130


                 ..
gi 923062878 381 KS 382
Cdd:PRK14868 131 YS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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