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Conserved domains on  [gi|923079478|ref|WP_053462457|]
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MULTISPECIES: enoyl-CoA hydratase/isomerase family protein [Stenotrophomonas]

Protein Classification

enoyl-CoA hydratase/isomerase family protein( domain architecture ID 10158671)

enoyl-CoA hydratase/isomerase family protein similar to enoyl-CoA hydratase, which catalyzes the second step in the beta-oxidation pathway of fatty acid metabolism, the syn-addition of a water molecule across the double bond of a trans-2-enoyl-CoA thioester, resulting in the formation of a beta-hydroxyacyl-CoA thioester

CATH:  1.10.12.10
Gene Ontology:  GO:0003824
PubMed:  18470480|11263873
SCOP:  4000036

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
5-203 6.30e-49

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


:

Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 160.03  E-value: 6.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   5 IEVINHGPIRELRLARPP-VNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDTWN 82
Cdd:cd06558    1 VLVERDGGVATITLNRPEkRNALSLEMLDELAAALdEAEADPDVRVVVLTGAGKAFCAGADLKELAALSDAGEEARAFIR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  83 AFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRA 162
Cdd:cd06558   81 ELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDA------KFGLPEVKLGLVPGGGGTQRLPRLVGPARA 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 923079478 163 GALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNL 203
Cdd:cd06558  155 RELLLTGRRISAEEALELGLVDEVVPDEELLAAALELARRL 195
 
Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
5-203 6.30e-49

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 160.03  E-value: 6.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   5 IEVINHGPIRELRLARPP-VNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDTWN 82
Cdd:cd06558    1 VLVERDGGVATITLNRPEkRNALSLEMLDELAAALdEAEADPDVRVVVLTGAGKAFCAGADLKELAALSDAGEEARAFIR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  83 AFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRA 162
Cdd:cd06558   81 ELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDA------KFGLPEVKLGLVPGGGGTQRLPRLVGPARA 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 923079478 163 GALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNL 203
Cdd:cd06558  155 RELLLTGRRISAEEALELGLVDEVVPDEELLAAALELARRL 195
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
10-255 6.63e-49

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 161.49  E-value: 6.63e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  10 HGPIRELRLARP-PVNALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDVpHLLSHGDDKHKLLDTWNAFFGA 87
Cdd:COG1024    6 EGGVATITLNRPeKLNALSLEMLAELAAALDEAEADPDvRVVVLTGAGKAFCAGADL-KELAAAADPEEARAFARGLQRL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  88 VRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLT 167
Cdd:COG1024   85 FRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDA------RFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 168 TGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEALHPDL-IQLDRFVEAWFAPDAQ 246
Cdd:COG1024  159 TGRRIDAEEALELGLVNRVVPDDELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALeLEAEAFAELFASEDAR 238

                 ....*....
gi 923079478 247 NALQALVAR 255
Cdd:COG1024  239 EGIAAFLEK 247
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
13-208 1.41e-32

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 119.39  E-value: 1.41e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   13 IRELRLARP-PVNALDTDLCRQLIHAIELAMAEDAHG-IVLSGSERIFTGGMDVPHLLSHGDDKHKllDTWNAFFGAVRT 90
Cdd:pfam00378   6 VAVITLNRPeAVNALSAELITELIQALEKLRTDPSVRaVVLTGGDKAFCAGADLKEMYGEGPAHQA--LYRENVLDLWTL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   91 LAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLTTGA 170
Cdd:pfam00378  84 LYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNA------SFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGR 157
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 923079478  171 LVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPR 208
Cdd:pfam00378 158 RISAQEALKWGLVDKVVPEDQLLDEARELAEKLAEKSP 195
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
4-207 3.33e-29

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 110.91  E-value: 3.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   4 LIEVINHGpIRELRLARPPV-NALDTDLCRQLI-HAIELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDT- 80
Cdd:PRK08138  10 LLERPADG-VALLRLNRPEArNALNMEVRQQLAeHFTELSEDPDIRAIVLTGGEKVFAAGADIKEFATAGAIEMYLRHTe 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  81 --WNAffgavrtLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPyaiglnEVQVGLI-APEGIQRLLRrAV 157
Cdd:PRK08138  89 ryWEA-------IAQCPKPVIAAVNGYALGGGCELAMHADIIVAGESASFGQP------EIKVGLMpGAGGTQRLVR-AV 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQP 207
Cdd:PRK08138 155 GKFKAMRMALTGCMVPAPEALAIGLVSEVVEDEQTLPRALELAREIARMP 204
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
23-188 3.68e-11

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 62.93  E-value: 3.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   23 VNALDTDLCRQLIHAIELAMAEDA--HGIVLSGSERIFTGGMDVPHL-----------LSHGDDKhklldtwnaffgAVR 89
Cdd:TIGR02441  35 VNTLSKELFAEFKEVMNELWTNEAikSAVLISGKPGSFVAGADIQMIaacktaqevtqLSQEGQE------------MFE 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   90 TLAESRIPVVAAITGHAPAGGCVLALCCDYRVmarsADPSRPYAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLTTG 169
Cdd:TIGR02441 103 RIEKSQKPIVAAISGSCLGGGLELALACHYRI----ATKDRKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPAALDMMLTG 178
                         170
                  ....*....|....*....
gi 923079478  170 ALVPAEQALQIGLVDELAE 188
Cdd:TIGR02441 179 KKIRADRAKKMGIVDQLVD 197
 
Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
5-203 6.30e-49

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 160.03  E-value: 6.30e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   5 IEVINHGPIRELRLARPP-VNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDTWN 82
Cdd:cd06558    1 VLVERDGGVATITLNRPEkRNALSLEMLDELAAALdEAEADPDVRVVVLTGAGKAFCAGADLKELAALSDAGEEARAFIR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  83 AFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRA 162
Cdd:cd06558   81 ELQELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDA------KFGLPEVKLGLVPGGGGTQRLPRLVGPARA 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 923079478 163 GALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNL 203
Cdd:cd06558  155 RELLLTGRRISAEEALELGLVDEVVPDEELLAAALELARRL 195
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
10-255 6.63e-49

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 161.49  E-value: 6.63e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  10 HGPIRELRLARP-PVNALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDVpHLLSHGDDKHKLLDTWNAFFGA 87
Cdd:COG1024    6 EGGVATITLNRPeKLNALSLEMLAELAAALDEAEADPDvRVVVLTGAGKAFCAGADL-KELAAAADPEEARAFARGLQRL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  88 VRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLT 167
Cdd:COG1024   85 FRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDA------RFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 168 TGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEALHPDL-IQLDRFVEAWFAPDAQ 246
Cdd:COG1024  159 TGRRIDAEEALELGLVNRVVPDDELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALeLEAEAFAELFASEDAR 238

                 ....*....
gi 923079478 247 NALQALVAR 255
Cdd:COG1024  239 EGIAAFLEK 247
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
13-208 1.41e-32

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 119.39  E-value: 1.41e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   13 IRELRLARP-PVNALDTDLCRQLIHAIELAMAEDAHG-IVLSGSERIFTGGMDVPHLLSHGDDKHKllDTWNAFFGAVRT 90
Cdd:pfam00378   6 VAVITLNRPeAVNALSAELITELIQALEKLRTDPSVRaVVLTGGDKAFCAGADLKEMYGEGPAHQA--LYRENVLDLWTL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   91 LAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLTTGA 170
Cdd:pfam00378  84 LYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNA------SFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGR 157
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 923079478  171 LVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPR 208
Cdd:pfam00378 158 RISAQEALKWGLVDKVVPEDQLLDEARELAEKLAEKSP 195
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
4-207 3.33e-29

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 110.91  E-value: 3.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   4 LIEVINHGpIRELRLARPPV-NALDTDLCRQLI-HAIELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDT- 80
Cdd:PRK08138  10 LLERPADG-VALLRLNRPEArNALNMEVRQQLAeHFTELSEDPDIRAIVLTGGEKVFAAGADIKEFATAGAIEMYLRHTe 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  81 --WNAffgavrtLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPyaiglnEVQVGLI-APEGIQRLLRrAV 157
Cdd:PRK08138  89 ryWEA-------IAQCPKPVIAAVNGYALGGGCELAMHADIIVAGESASFGQP------EIKVGLMpGAGGTQRLVR-AV 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQP 207
Cdd:PRK08138 155 GKFKAMRMALTGCMVPAPEALAIGLVSEVVEDEQTLPRALELAREIARMP 204
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
18-225 1.14e-28

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 109.97  E-value: 1.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  18 LARPPVNALDTDLCRQLIHAIElAMAEDA--HGIVLSGSER--IFTGGMDVPHLLSHGDDKHKLLDTW---NAFFgaVRt 90
Cdd:PLN03214  27 LAKEPVNSMTLAMWRSLDDALT-ALENDPtvRGVVFASGLRrdVFTAGNDIAELYAPKTSAARYAEFWltqTTFL--VR- 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  91 LAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLL-RRAVGVHRAGALLTTG 169
Cdd:PLN03214 103 LLRSRLATVCAIRGACPAGGCAVSLCCDYRLQTTEG------TMGLNEVALGIPVPKFWARLFmGRVIDRKVAESLLLRG 176
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 923079478 170 ALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEA 225
Cdd:PLN03214 177 RLVRPAEAKQLGLIDEVVPAAALMEAAASAMERALKLPSAARAATKALLREEFSAA 232
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
1-217 5.81e-27

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 104.73  E-value: 5.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTlIEVINHGPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGD--DKHKL 77
Cdd:PRK07659   5 MES-VVVKYEGRVATIMLNRPEAlNALDEPMLKELLQALKEVAESSAHIVVLRGNGRGFSAGGDIKMMLSSNDesKFDGV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  78 LDTWNaffGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAV 157
Cdd:PRK07659  84 MNTIS---EIVVTLYTMPKLTISAIHGPAAGLGLSIALTADYVIADISA------KLAMNFIGIGLIPDGGGHFFLQKRV 154
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLVDELAEGDlVVARAVAWLQNLLRQPRQPMLLTRAI 217
Cdd:PRK07659 155 GENKAKQIIWEGKKLSATEALDLGLIDEVIGGD-FQTAAKQKISEWLQKPLKAMIETKQI 213
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
1-255 1.54e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 98.40  E-value: 1.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARP-PVNALDTDLCRQLIHAIELAmAEDA--HGIVLSGSERIFTGGMDVPHLLSHGDDKHKL 77
Cdd:PRK06688   3 MVTDLLVELEDGVLTITINRPdKKNALTAAMYQALADALEAA-ATDPavRVVVLTGAGRAFSAGGDIKDFPKAPPKPPDE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  78 LDtwnAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAV 157
Cdd:PRK06688  82 LA---PVNRFLRAIAALPKPVVAAVNGPAVGVGVSLALACDLVYASESA------KFSLPFAKLGLCPDAGGSALLPRLI 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLT-RAIARADLHEALHPDLIQLDRF 236
Cdd:PRK06688 153 GRARAAEMLLLGEPLSAEEALRIGLVNRVVPAAELDAEADAQAAKLAAGPASALRYTkRAINAATLTELEEALAREAAGF 232
                        250
                 ....*....|....*....
gi 923079478 237 VEAWFAPDAQNALQALVAR 255
Cdd:PRK06688 233 GRLLRTPDFREGATAFIEK 251
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
16-216 7.22e-23

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 92.98  E-value: 7.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  16 LRLARPPVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDtwNAFFGAVRTLAES 94
Cdd:PRK05869  21 LLLSRPPTNALTRQVYREIVAAAnELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQEADTAA--RVRQQAVDAVAAI 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  95 RIPVVAAITGHAPAGGCVLALCCDYRVmarSADPSRpyaIGLNEVQVGLI-APEGIQRLlRRAVGVHRAGALLTTGALVP 173
Cdd:PRK05869  99 PKPTVAAITGYALGAGLTLALAADWRV---SGDNVK---FGATEILAGLApSGDGMARL-TRAAGPSRAKELVFSGRFFD 171
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 923079478 174 AEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRA 216
Cdd:PRK05869 172 AEEALALGLIDEMVAPDDVYDAAAAWARRFLDGPPHALAAAKA 214
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
10-236 1.42e-21

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 90.21  E-value: 1.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  10 HGPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDAHG-IVLSGSERIFTGGMDVPHLlSHGDDKHKLLDTWNAFFGA 87
Cdd:PRK09674   9 QQRVLLLTLNRPEArNALNNALLTQLVNELEAAATDTSIGvCVITGNARFFAAGADLNEM-AEKDLAATLNDPRPQLWQR 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  88 VRTLAEsriPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLI-APEGIQRLLRrAVGVHRAGALL 166
Cdd:PRK09674  88 LQAFNK---PLIAAVNGYALGAGCELALLCDIVIAGENA------RFGLPEITLGIMpGAGGTQRLIR-SVGKSLASQMV 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 167 TTGALVPAEQALQIGLVDELAEGDLVVARAvawLQNLLRQPRQPMLLTRAiARADLHEALHPDLIQLDRF 236
Cdd:PRK09674 158 LTGESITAQQAQQAGLVSEVFPPELTLERA---LQLASKIARHSPLALRA-AKQALRQSQEVDLQAGLAQ 223
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
18-238 3.14e-21

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 89.76  E-value: 3.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  18 LARPP-VNALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDVPHLLSHGDD--------------KHKLLDTW 81
Cdd:PRK06210  21 LNRPDrLNAWTPVMEAEVYAAMDRAEADPAvRVIVLTGAGRGFCAGADMGELQTIDPSdgrrdtdvrpfvgnRRPDYQTR 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  82 NAFFGAVRTlaesriPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYAiglnevQVGLIAPEGIQRLLRRAVGVHR 161
Cdd:PRK06210 101 YHFLTALRK------PVIAAINGACAGIGLTHALMCDVRFAADGAKFTTAFA------RRGLIAEHGISWILPRLVGHAN 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 162 AGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQ--PRQPMLLTR------------AIARAD--LHEA 225
Cdd:PRK06210 169 ALDLLLSARTFYAEEALRLGLVNRVVPPDELMERTLAYAEDLARNvsPASMAVIKRqlyedafqtlaeATARANreMHES 248
                        250
                 ....*....|....*
gi 923079478 226 L-HPDLIQ-LDRFVE 238
Cdd:PRK06210 249 LqRPDFIEgVASFLE 263
PRK06213 PRK06213
crotonase/enoyl-CoA hydratase family protein;
1-226 1.02e-20

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235744  Cd Length: 229  Bit Score: 87.34  E-value: 1.02e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPPVNALDTDLCRQLIHAIELAmAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLdt 80
Cdd:PRK06213   1 MSELVSYTLEDGVATITLDDGKVNALSPAMIDALNAALDQA-EDDRAVVVITGQPGIFSGGFDLKVMTSGAQAAIALL-- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  81 wNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARsadpsRPYAIGLNEVQVGLIAPEG---IQRLLRRAV 157
Cdd:PRK06213  78 -TAGSTLARRLLSHPKPVIVACTGHAIAKGAFLLLSADYRIGVH-----GPFKIGLNEVAIGMTMPHAaieLARDRLTPS 151
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 923079478 158 GVHRAGALlttGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEAL 226
Cdd:PRK06213 152 AFQRAVIN---AEMFDPEEAVAAGFLDEVVPPEQLLARAQAAARELAGLNMGAHAATKLKVRAAALEAI 217
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
1-255 1.69e-20

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 87.47  E-value: 1.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPP-VNALDTDLCRQLIHAIELAMA-EDAHGIVLSGSERIFTGGMDVPHLLshGDDKHKLL 78
Cdd:PRK05870   1 MMDPVLLDVDDGVALITVNDPDrRNAVTAEMSAQLRAAVAAAEAdPDVHALVVTGAGKAFCAGADLTALG--AAPGRPAE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  79 DTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVmarsADPSRPYAIGLNEVqvGLIAPEGIQRLLRRAVG 158
Cdd:PRK05870  79 DGLRRIYDGFLAVASCPLPTIAAVNGAAVGAGLNLALAADVRI----AGPKALFDARFQKL--GLHPGGGATWMLQRAVG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 159 VHRAGALLTTGALVPAEQALQIGLVDELAEGdlVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEALHPDLIQLDRFVE 238
Cdd:PRK05870 153 PQVARAALLFGMRFDAEAAVRHGLALMVADD--PVAAALELAAGPAAAPRELVLATKASMRATASLAQHAAAVEFELGPQ 230
                        250
                 ....*....|....*....
gi 923079478 239 AWFA--PDAQNALQALVAR 255
Cdd:PRK05870 231 AASVqsPEFAARLAAAQRR 249
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
4-258 6.79e-20

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 85.46  E-value: 6.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   4 LIEVINHGPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDAHGIVLSGSERIFTGGMDvphlLSHGDDKHKLLDTWn 82
Cdd:PRK07854   1 MIGVTRDGQVLTIELQRPERrNALNAELCEELREAVRKAVDESARAIVLTGQGTVFCAGAD----LSGDVYADDFPDAL- 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  83 afFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYAiglnevQVGLIAPEGIQRLLRRAVGVHRA 162
Cdd:PRK07854  76 --IEMLHAIDAAPVPVIAAINGPAIGAGLQLAMACDLRVVAPEAYFQFPVA------KYGIALDNWTIRRLSSLVGGGRA 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 163 GALLTTGALVPAEQALQIGLVDELaeGDLVVARAVAwlqnlLRQPRQPMLLTRAIARA--DLHEALHPDLIQLDRFVEAW 240
Cdd:PRK07854 148 RAMLLGAEKLTAEQALATGMANRI--GTLADAQAWA-----AEIAGLAPLALQHAKRVlnDDGAIEEAWPAHKELFDKAW 220
                        250
                 ....*....|....*...
gi 923079478 241 FAPDAQnalQALVARLGK 258
Cdd:PRK07854 221 ASQDAI---EAQVARIEK 235
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
13-198 1.70e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 84.69  E-value: 1.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  13 IRELRLARPPVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLLS--HGDDKHKLLDTWNAFFGAVR 89
Cdd:PRK07658  12 VAVITLNHPPANALSSQVLHELSELLdQVEKDDNVRVVVIHGEGRFFSAGADIKEFTSvtEAEQATELAQLGQVTFERVE 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  90 TLAesrIPVVAAITGHAPAGGCVLALCCDYRVMARSADpsrpyaIGLNEVQVGLIaP--EGIQRLLrRAVGVHRAGALLT 167
Cdd:PRK07658  92 KFS---KPVIAAIHGAALGGGLELAMSCHIRFATESAK------LGLPELNLGLI-PgfAGTQRLP-RYVGKAKALEMML 160
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 923079478 168 TGALVPAEQALQIGLV------DELAEGDLVVARAVA 198
Cdd:PRK07658 161 TSEPITGAEALKWGLVngvfpeETLLDDAKKLAKKIA 197
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
1-198 4.94e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 83.48  E-value: 4.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVIN-HGPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDVPHLlshGDDKHKL 77
Cdd:PRK06190   1 MTEPILLVEtHDRVRTLTLNRPEArNALSAALRRALFAALAEADADDDvDVVVLTGADPAFCAGLDLKEL---GGDGSAY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  78 LDTwNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVM---ARSADpsrpyaiglNEVQVGLIAPEGIQRLLR 154
Cdd:PRK06190  78 GAQ-DALPNPSPAWPAMRKPVIGAINGAAVTGGLELALACDILIAserARFAD---------THARVGILPGWGLSVRLP 147
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 923079478 155 RAVGVHRAGALLTTGALVPAEQALQIGLVDELAEGD--LVVARAVA 198
Cdd:PRK06190 148 QKVGIGRARRMSLTGDFLDAADALRAGLVTEVVPHDelLPRARRLA 193
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
13-201 8.99e-19

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 85.30  E-value: 8.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  13 IRELRLARP-PVNALDTDLCRQLIHAIE-LAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDTWNAFFGAVRT 90
Cdd:PRK11730  17 IAELVFDAPgSVNKLDRATLASLGEALDaLEAQSDLKGLLLTSAKDAFIVGADITEFLSLFAAPEEELSQWLHFANSIFN 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  91 -LAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLTTG 169
Cdd:PRK11730  97 rLEDLPVPTVAAINGYALGGGCECVLATDYRVASPDA------RIGLPETKLGIMPGFGGTVRLPRLIGADNALEWIAAG 170
                        170       180       190
                 ....*....|....*....|....*....|..
gi 923079478 170 ALVPAEQALQIGLVDELAEGDLVVARAVAWLQ 201
Cdd:PRK11730 171 KDVRAEDALKVGAVDAVVAPEKLQEAALALLK 202
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
16-198 1.81e-18

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 82.01  E-value: 1.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  16 LRLARP-PVNALDTDLCRQLIHAIELAMAEDAHG-IVLSGSERIFTGGMDVPHLLSHGddkhkLLDTWNA-FFGAVRTLA 92
Cdd:PRK05862  17 ITLNRPkALNALNDALMDELGAALAAFDADEGIGaIVITGSEKAFAAGADIKEMADLS-----FMDVYKGdYITNWEKVA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  93 ESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPyaiglnEVQVGLIAPEGIQRLLRRAVGVHRAGALLTTGALV 172
Cdd:PRK05862  92 RIRKPVIAAVAGYALGGGCELAMMCDIIIAADTAKFGQP------EIKLGVLPGMGGSQRLTRAVGKAKAMDLCLTGRMM 165
                        170       180       190
                 ....*....|....*....|....*....|..
gi 923079478 173 PAEQALQIGLV------DELAEGDLVVARAVA 198
Cdd:PRK05862 166 DAAEAERAGLVsrvvpaDKLLDEALAAATTIA 197
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
10-227 1.89e-18

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 82.09  E-value: 1.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  10 HGPIRELRLARPPV-NALDTDLCRQLIHAIElAMAED---AHGIVLSGSERIF------TGGMDVPHLLSHGDDKHKLLD 79
Cdd:PRK05981  11 DGGVAILTLDHPEVmNAVSIDMLGGLAEALD-AIEDGkaeVRCLVLTGAGRGFctganlQGRGSGGRESDSGGDAGAALE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  80 TwnAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYAiglnevQVGLIAPEGIQRLLRRAVGV 159
Cdd:PRK05981  90 T--AYHPFLRRLRNLPCPIVTAVNGPAAGVGMSFALMGDLILCARSAYFLQAFR------RIGLVPDGGSTWLLPRLVGK 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 923079478 160 HRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAI----ARADLHEALH 227
Cdd:PRK05981 162 ARAMELSLLGEKLPAETALQWGLVNRVVDDAELMAEAMKLAHELANGPTVALGLIRKLywdsPENDFEEQLN 233
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
11-190 5.72e-18

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 80.56  E-value: 5.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  11 GPIRELRLARP-PVNALDTDLCRQLIHAIE-LAMAEDAHGIVLSGS-ERIFTGGMDVPHL--LSHGDDKhKLLDTWNAFF 85
Cdd:PRK05809  12 GHIAVVTINRPkALNALNSETLKELDTVLDdIENDDNVYAVILTGAgEKAFVAGADISEMkdLNEEEGR-KFGLLGNKVF 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  86 GAVRTLAEsriPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPyaiglnevQVGL-IAP--EGIQRlLRRAVGVHRA 162
Cdd:PRK05809  91 RKLENLDK---PVIAAINGFALGGGCELSMACDIRIASEKAKFGQP--------EVGLgITPgfGGTQR-LARIVGPGKA 158
                        170       180
                 ....*....|....*....|....*...
gi 923079478 163 GALLTTGALVPAEQALQIGLVDELAEGD 190
Cdd:PRK05809 159 KELIYTGDMINAEEALRIGLVNKVVEPE 186
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
1-206 1.09e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 79.96  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPPVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGS-ERIFTGGMDVpHLLSHGDdKHKLL 78
Cdd:PRK09076   1 MMIELDLEIDGHVAILTLNNPPANTWTADSLQALKQLVlELNADKDVYALVITGDgEKFFSAGADL-NLFADGD-KAVAR 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  79 DTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVG 158
Cdd:PRK09076  79 EMARRFGEAFEALSAFRGVSIAAINGYAMGGGLECALACDIRIAEEQA------QMALPEASVGLLPCAGGTQNLPWLVG 152
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 923079478 159 VHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQ 206
Cdd:PRK09076 153 EGWAKRMILCGERVDAATALRIGLVEEVVEKGEAREAALALAQKVANQ 200
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
1-198 1.23e-17

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 79.65  E-value: 1.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDAHGI-VLSGSERIFTGGMD--------VPHLLSH 70
Cdd:PRK08252   1 MSDEVLVERRGRVLIITINRPEArNAVNAAVAQGLAAALDELDADPDLSVgILTGAGGTFCAGMDlkafargeRPSIPGR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  71 GddkhklldtwnafFGAVrTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPE-GI 149
Cdd:PRK08252  81 G-------------FGGL-TERPPRKPLIAAVEGYALAGGFELALACDLIVAARDA------KFGLPEVKRGLVAAGgGL 140
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 923079478 150 QRLLRRaVGVHRAGALLTTGALVPAEQALQIGLVDELAE--GDLVVARAVA 198
Cdd:PRK08252 141 LRLPRR-IPYHIAMELALTGDMLTAERAHELGLVNRLTEpgQALDAALELA 190
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
11-205 3.05e-17

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 78.54  E-value: 3.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  11 GPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDAHGI-VLSGS-ERIFTGGMDVPHLLSHGDdkhklLDTWNAFFGA 87
Cdd:PRK06494  12 GHVTIVTLNRPEVmNALHLDAHFELEEVFDDFAADPEQWVaIVTGAgDKAFSAGNDLKEQAAGGK-----RGWPESGFGG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  88 VRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLT 167
Cdd:PRK06494  87 LTSRFDLDKPIIAAVNGVAMGGGFELALACDLIVAAENA------TFALPEPRVGLAALAGGLHRLPRQIGLKRAMGMIL 160
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 923079478 168 TGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLR 205
Cdd:PRK06494 161 TGRRVTAREGLELGFVNEVVPAGELLAAAERWADDILA 198
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
1-198 4.67e-17

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 78.00  E-value: 4.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARP-PVNALDTDLCRQLIHAIE-LAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLL 78
Cdd:PRK07509   1 MMDRVSVTIEDGIADVRLNRPdKMNALDFAMFEELIATIKrLKKDRGIRAVILSGEGGAFCAGLDVKSVASSPGNAVKLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  79 DTW-----NAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSrpyaigLNEVQVGLIAPEGIQRLL 153
Cdd:PRK07509  81 FKRlpgnaNLAQRVSLGWRRLPVPVIAALEGVCFGGGLQIALGADIRIAAPDTKLS------IMEAKWGLVPDMAGTVSL 154
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 923079478 154 RRAVGVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVA 198
Cdd:PRK07509 155 RGLVRKDVARELTYTARVFSAEEALELGLVTHVSDDPLAAALALA 199
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
1-226 1.78e-16

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 76.55  E-value: 1.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPPV-NAL-DTDLCRQLIHAIELAMA-EDAHGIVLSGSERIFTGGMDVPHLLS-HGDDKHK 76
Cdd:PRK09245   1 MTDFLLVERDGHIVTLTMNRPETrNALsDNDAVDALVAACAAINAdRSVRAVILTGAGTAFSSGGNVKDMRArVGAFGGS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  77 LLDTWNAFFGA----VRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRL 152
Cdd:PRK09245  81 PADIRQGYRHGiqriPLALYNLEVPVIAAVNGPAIGAGCDLACMCDIRIASETA------RFAESFVKLGLIPGDGGAWL 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 923079478 153 LRRAVGVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEAL 226
Cdd:PRK09245 155 LPRIIGMARAAEMAFTGDAIDAATALEWGLVSRVVPADQLLPAARALAERIAANPPHALRLTKRLLREGQHASL 228
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
1-234 2.57e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 76.11  E-value: 2.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPP-VNALDTDLCRQLIHAIELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKH-KLL 78
Cdd:PRK08140   2 MYETILLAIEAGVATLTLNRPDkLNSFTREMHRELREALDQVEDDGARALLLTGAGRGFCAGQDLADRDVTPGGAMpDLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  79 DTWNAFFGA-VRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYAiglnevQVGLIAPEGIQRLLRRAV 157
Cdd:PRK08140  82 ESIETFYNPlVRRLRALPLPVIAAVNGVAAGAGANLALACDIVLAARSASFIQAFV------KIGLVPDSGGTWFLPRLV 155
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEALHPdliQLD 234
Cdd:PRK08140 156 GMARALGLALLGEKLSAEQAEQWGLIWRVVDDAALADEAQQLAAHLATQPTRGLALIKQAMNASATNTLDA---QLD 229
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
22-215 9.97e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 74.30  E-value: 9.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  22 PVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSG-SERIFTGGMDVPHLLShgddkhklLD--TWNAFFGAVRTLAES--- 94
Cdd:PRK06143  27 SLNILGTPVILALTQALrWLAADPDVRVLVLRGaGEKAFIGGADIKEMAT--------LDqaSAEAFISRLRDLCDAvrh 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  95 -RIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLiaPEGIQR-LLRRAVGVHRAGALLTTGALV 172
Cdd:PRK06143  99 fPVPVIARIPGWCLGGGLELAAACDLRIAAHDA------QFGMPEVRVGI--PSVIHAaLLPRLIGWARTRWLLLTGETI 170
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 923079478 173 PAEQALQIGLVDE---LAEGDLVVARAVAWL----QNLLRQprQPMLLTR 215
Cdd:PRK06143 171 DAAQALAWGLVDRvvpLAELDAAVERLAASLagcgPQALRQ--QKRLLRE 218
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
1-198 1.10e-15

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 74.35  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPPVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDV---PHLLSHGDDKHK 76
Cdd:PRK06495   2 MMSQLKLEVSDHVAVVTLDNPPVNALSRELRDELIAVFdEISERPDVRVVVLTGAGKVFCAGADLkgrPDVIKGPGDLRA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  77 LLDTWNAFFGAVRtlaESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIapeGIQRLLRRA 156
Cdd:PRK06495  82 HNRRTRECFHAIR---ECAKPVIAAVNGPALGAGLGLVASCDIIVASENA------VFGLPEIDVGLA---GGGKHAMRL 149
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 923079478 157 VGVHRAGALLTTGALVPAEQALQIGLV------DELAEGDLVVARAVA 198
Cdd:PRK06495 150 FGHSLTRRMMLTGYRVPAAELYRRGVIeaclppEELMPEAMEIAREIA 197
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
91-185 4.14e-15

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 74.55  E-value: 4.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  91 LAESRIPVVAAITGHAPAGGCVLALCCDYRVmarsADPSRPYAIGLNEVQVGLI-APEGIQRLLRRaVGVHRAGALLTTG 169
Cdd:PRK11154  97 IEALPIPVVAAIHGACLGGGLELALACHYRV----CTDDPKTVLGLPEVQLGLLpGSGGTQRLPRL-IGVSTALDMILTG 171
                         90
                 ....*....|....*.
gi 923079478 170 ALVPAEQALQIGLVDE 185
Cdd:PRK11154 172 KQLRAKQALKLGLVDD 187
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
24-245 4.31e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 72.72  E-value: 4.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  24 NALDTDLCRQLIHAIELAMAEDAHG-IVLSGSERIFTGGMDVPHLLSHGD----DKHKLLDTWNAFFGAVRTLAEsriPV 98
Cdd:PRK07511  25 NALHPDMYAAGIEALNTAERDPSIRaVVLTGAGGFFCAGGNLNRLLENRAkppsVQAASIDGLHDWIRAIRAFPK---PV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  99 VAAITGHAPAGGCVLALCCDYRVMARSADPSRPYaiglneVQVGLIAPEGIQRLLRRAVGVHRAGALLTTGALVPAEQAL 178
Cdd:PRK07511 102 IAAVEGAAAGAGFSLALACDLLVAARDAKFVMAY------VKVGLTPDGGGSWFLARALPRQLATELLLEGKPISAERLH 175
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 923079478 179 QIGLVDELAEGDLVVARAVAWLQNLLRQPRQPML----LTRAIARADLHEALhpdLIQLDRFVEAWFAPDA 245
Cdd:PRK07511 176 ALGVVNRLAEPGQALAEALALADQLAAGSPNALAriksLIADAPEATLAAQL---EAERDHFVASLHHADA 243
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
39-207 1.26e-14

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 71.54  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  39 ELAMAEDAHGIVLSGSERIFTGGMDVPHLLSH--GDDKHKLLDtWNAFFGA-VRTLAESRIPVVAAITGHAPAGGCVLAL 115
Cdd:PRK08258  55 ELVYADDVKAVVLTGAGGNFCSGGDVHEIIGPltKMDMPELLA-FTRMTGDlVKAMRACPQPIIAAVDGVCAGAGAILAM 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 116 CCDYRVmarsADPSRPYAIGLNevQVGLI-APEGIQRLLRRAVGVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVA 194
Cdd:PRK08258 134 ASDLRL----GTPSAKTAFLFT--RVGLAgADMGACALLPRIIGQGRASELLYTGRSMSAEEGERWGFFNRLVEPEELLA 207
                        170
                 ....*....|...
gi 923079478 195 RAVAWLQNLLRQP 207
Cdd:PRK08258 208 EAQALARRLAAGP 220
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
5-198 3.88e-14

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 70.00  E-value: 3.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   5 IEVINHgpIRELRLARP-PVNALDTDLCRQLIHAIELAMAED-AHGIVLSGSERIFTGGMDVPHLLSHGDDKHK------ 76
Cdd:PRK06142  10 VELADH--VAQVTLNRPgKGNAMNPAFWSELPEIFRWLDADPeVRAVVLSGSGKHFSYGIDLPAMAGVFGQLGKdglarp 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  77 ---LLDTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSrpyaigLNEVQVGLIAPEG-IQRl 152
Cdd:PRK06142  88 rtdLRREILRLQAAINAVADCRKPVIAAVQGWCIGGGVDLISACDMRYASADAKFS------VREVDLGMVADVGsLQR- 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 923079478 153 LRRAVGVHRAGALLTTGALVPAEQALQIGLVDEL---AEGDLVVARAVA 198
Cdd:PRK06142 161 LPRIIGDGHLRELALTGRDIDAAEAEKIGLVNRVyddADALLAAAHATA 209
PLN02888 PLN02888
enoyl-CoA hydratase
20-226 9.65e-14

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 69.01  E-value: 9.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  20 RP-PVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDV--PHLLSHGDDKHKLLDTwnaffgaVRTLAESR 95
Cdd:PLN02888  27 RPkALNALTRPMMVELAAAFkRLDEDDSVKVIILTGSGRAFCSGVDLtaAEEVFKGDVKDVETDP-------VAQMERCR 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  96 IPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYAiglnevQVGLIAPEGIQRLLRRAVGVHRAGALLTTGALVPAE 175
Cdd:PLN02888 100 KPIIGAINGFAITAGFEIALACDILVASRGAKFIDTHA------KFGIFPSWGLSQKLSRIIGANRAREVSLTAMPLTAE 173
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 923079478 176 QALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAI----ARADLHEAL 226
Cdd:PLN02888 174 TAERWGLVNHVVEESELLKKAREVAEAIIKNNQGMVLRYKSVindgLKLDLGHAL 228
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
1-203 1.24e-13

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 68.57  E-value: 1.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPPVNALDTDLCRQLiHAIELAMAEDAH---GIVLSGSERIFTGGMDVpHLLSHGDDKHKl 77
Cdd:PRK03580   1 MSESLHTTRNGSILEITLDRPKANAIDAKTSFAM-GEVFLNFRDDPElrvAIITGAGEKFFSAGWDL-KAAAEGEAPDA- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  78 lDTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEG-IQRLLRRa 156
Cdd:PRK03580  78 -DFGPGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCADNA------SFALPEAKLGIVPDSGgVLRLPKR- 149
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 923079478 157 VGVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNL 203
Cdd:PRK03580 150 LPPAIANEMVMTGRRMDAEEALRWGIVNRVVPQAELMDRARELAQQL 196
PLN02600 PLN02600
enoyl-CoA hydratase
13-184 1.90e-13

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 67.91  E-value: 1.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  13 IRELRLARPPV-NALDTDLCRQLIHAIELAMAEDAHGIVL--SGSERIFTGGMDVPHLLSHG-DDKHKLLDTWNAFFGAV 88
Cdd:PLN02600   5 IVELRLDRPEAkNAIGKEMLRGLRSAFEKIQADASARVVMlrSSVPGVFCAGADLKERRKMSpSEVQKFVNSLRSTFSSL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  89 RTLAesrIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLTT 168
Cdd:PLN02600  85 EALS---IPTIAVVEGAALGGGLELALSCDLRICGEEA------VFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFT 155
                        170
                 ....*....|....*.
gi 923079478 169 GALVPAEQALQIGLVD 184
Cdd:PLN02600 156 GRRIGAREAASMGLVN 171
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
18-192 1.92e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 68.32  E-value: 1.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  18 LARPP-VNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMD------VPHL-----LSHGDDKHKLLDTwnaf 84
Cdd:PRK05864  25 LNRPErMNSMAFDVMVPLKEALaEVSYDNSVRVVVLTGAGRGFSSGADhksagvVPHVegltrPTYALRSMELLDD---- 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  85 fgAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpY--AIGLNEvqvGLIAPE-GIQRLLRRAVGVHR 161
Cdd:PRK05864 101 --VILALRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSA-----YfrAAGINN---GLTASElGLSYLLPRAIGSSR 170
                        170       180       190
                 ....*....|....*....|....*....|..
gi 923079478 162 AGALLTTGALVPAEQALQIGLVD-ELAEGDLV 192
Cdd:PRK05864 171 AFEIMLTGRDVDAEEAERIGLVSrQVPDEQLL 202
PLN02267 PLN02267
enoyl-CoA hydratase/isomerase family protein
26-184 6.62e-13

enoyl-CoA hydratase/isomerase family protein


Pssm-ID: 215151  Cd Length: 239  Bit Score: 66.28  E-value: 6.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  26 LDTDLCRQLIHAIELAMAEDAHGIVL--SGSERIFTGGMDVPHLLSHGDDKHKLLDTWNAFFGAVRTLAESRIPVVAAIT 103
Cdd:PLN02267  23 LNPTLIDSIRSALRQVKSQATPGSVLitTAEGKFFSNGFDLAWAQAAGSAPSRLHLMVAKLRPLVADLISLPMPTIAAVT 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 104 GHAPAGGCVLALCCDYRVMARsaDPSRPYaigLNEVQVGLIAPEGIQRLLRRAVGVHRA-GALLTTGALVPAEQALQIGL 182
Cdd:PLN02267 103 GHASAAGFILALSHDYVLMRK--DRGVLY---MSEVDIGLPLPDYFMALLRAKIGSPAArRDVLLRAAKLTAEEAVEMGI 177

                 ..
gi 923079478 183 VD 184
Cdd:PLN02267 178 VD 179
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
1-226 2.41e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 64.95  E-value: 2.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDVPHLLSHGD-DKHKL 77
Cdd:PRK05995   2 MYETLEIEQRGQVATVTLNRPDVrNAFNETVIAELTAAFRALDADDSvRAVVLAGAGKAFCAGADLNWMKKMAGySDDEN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  78 LDTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIaPEGIQRLLRRAV 157
Cdd:PRK05995  82 RADARRLADMLRAIYRCPKPVIARVHGDAYAGGMGLVAACDIAVAADHA------VFCLSEVRLGLI-PATISPYVIRAM 154
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVArAVAWLQNLLRQP-----RQPMLLTRAIARADLHEAL 226
Cdd:PRK05995 155 GERAARRYFLTAERFDAAEALRLGLVHEVVPAEALDA-KVDELLAALVANspqavRAGKRLVRDVAGRPIDAAL 227
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
2-198 2.71e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 64.76  E-value: 2.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   2 TTLIEVINHGpIRELRLARP-PVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGS-ERIFTGGMDVPHL--LSHGDDKHK 76
Cdd:PRK07657   4 NISVDYVTPH-VVKITLNRPrAANALSLALLEELQNILtQINEEANVRVVILTGAgEKAFCAGADLKERagMNEEQVRHA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  77 LldtwnaffGAVRTLAES----RIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRL 152
Cdd:PRK07657  83 V--------SLIRTTMEMveqlPQPVIAAINGIALGGGLELALACDFRIAAESA------SLGLTETTLAIIPGAGGTQR 148
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 923079478 153 LRRAVGVHRAGALLTTGALVPAEQALQIGLV------DELAEGDLVVARAVA 198
Cdd:PRK07657 149 LPRLIGVGRAKELIYTGRRISAQEAKEIGLVefvvpaHLLEEKAIEIAEKIA 200
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
1-198 6.92e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 63.87  E-value: 6.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGpIRELRLARPP-VNALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDvphlLSHGDDKHKLL 78
Cdd:PRK08260   3 YETIRYDVADG-IATITLNRPDkLNAFTVTMARELIEAFDAADADDAvRAVIVTGAGRAFCAGAD----LSAGGNTFDLD 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  79 DTWNAFF-----------GAVR------TLA--ESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEV 139
Cdd:PRK08260  78 APRTPVEadeedradpsdDGVRdgggrvTLRifDSLKPVIAAVNGPAVGVGATMTLAMDIRLASTAA------RFGFVFG 151
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 923079478 140 QVGlIAPEGIQR-LLRRAVGVHRAGALLTTGALVPAEQALQIGLVDELAEGD--LVVARAVA 198
Cdd:PRK08260 152 RRG-IVPEAASSwFLPRLVGLQTALEWVYSGRVFDAQEALDGGLVRSVHPPDelLPAARALA 212
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
10-198 8.38e-12

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 63.45  E-value: 8.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  10 HGPIRELRLARPPVNALDTDLCRQLIHAIELAMAE-DAHGIVLSGSERIFTGGMDVPHlLSHGDDKHKLLDTWNAFFGAV 88
Cdd:PRK07938   9 EPGIAEVTVDYPPVNALPSAGWFALADAITAAGADpDTRVVVLRAEGRGFNAGVDIKE-LQATPGFTALIDANRGCFAAF 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  89 RTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVG-LIAPEGIQRLlrraVGVHRAGALLT 167
Cdd:PRK07938  88 RAVYECAVPVIAAVHGFCLGGGIGLVGNADVIVASDDA------TFGLPEVDRGaLGAATHLQRL----VPQHLMRALFF 157
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 923079478 168 TGALVPAEQALQIGLV------DELAEGDLVVARAVA 198
Cdd:PRK07938 158 TAATITAAELHHFGSVeevvprDQLDEAALEVARKIA 194
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
24-255 1.41e-11

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 62.90  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  24 NALDTDLCRQLIHAIElAMAEDA--HGIVLSGSERIFTGGMDVPHLLSHGD-DKHKLLDTWNAFFGAVRTLAESRIPVVA 100
Cdd:PRK05674  28 NAFNAQMIRELILALD-QVQSDAslRFLLLRGRGRHFSAGADLAWMQQSADlDYNTNLDDARELAELMYNLYRLKIPTLA 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 101 AITGHAPAGGCVLALCCDYRVMARSADpsrpyaIGLNEVQVGLiAPEGIQRLLRRAVGVHRAGALLTTGALVPAEQALQI 180
Cdd:PRK05674 107 VVQGAAFGGALGLISCCDMAIGADDAQ------FCLSEVRIGL-APAVISPFVVKAIGERAARRYALTAERFDGRRAREL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 181 GLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEALHPDliqLDRFVEAWFA-----PDAQNALQALVAR 255
Cdd:PRK05674 180 GLLAESYPAAELEAQVEAWIANLLLNSPQALRASKDLLREVGDGELSPA---LRRYCENAIArirvsAEGQEGLRAFLEK 256
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
23-188 3.68e-11

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 62.93  E-value: 3.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   23 VNALDTDLCRQLIHAIELAMAEDA--HGIVLSGSERIFTGGMDVPHL-----------LSHGDDKhklldtwnaffgAVR 89
Cdd:TIGR02441  35 VNTLSKELFAEFKEVMNELWTNEAikSAVLISGKPGSFVAGADIQMIaacktaqevtqLSQEGQE------------MFE 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   90 TLAESRIPVVAAITGHAPAGGCVLALCCDYRVmarsADPSRPYAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLTTG 169
Cdd:TIGR02441 103 RIEKSQKPIVAAISGSCLGGGLELALACHYRI----ATKDRKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPAALDMMLTG 178
                         170
                  ....*....|....*....
gi 923079478  170 ALVPAEQALQIGLVDELAE 188
Cdd:TIGR02441 179 KKIRADRAKKMGIVDQLVD 197
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
18-196 8.14e-11

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 60.83  E-value: 8.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  18 LARPPV-NALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMD-------------------VPHLLSHGDDkhk 76
Cdd:PRK08272  25 LNRPEKgNAITADTPLELRAAVERADLDPGvHVILVSGAGKGFCAGYDlsayaegsssgggggaypgKRQAVNHLPD--- 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  77 llDTWN---------AFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPE 147
Cdd:PRK08272 102 --DPWDpmidyqmmsRFVRGFMSLWHAHKPTVAKVHGYCVAGGTDIALHCDQVIAADDA------KIGYPPTRVWGVPAT 173
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 923079478 148 G--IQRLlrravGVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARA 196
Cdd:PRK08272 174 GmwAYRL-----GPQRAKRLLFTGDCITGAQAAEWGLAVEAVPPEELDERT 219
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
1-255 1.08e-10

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 60.08  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPP-VNALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDVPHLLSHGDDKHKL- 77
Cdd:PRK07827   4 VDTLVRYAVDGGVATLTLDSPHnRNALSARLVAQLHDGLRAAAADPAvRAVVLTHTGGTFCAGADLSEAGGGGGDPYDAa 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  78 LDTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVmarsADPSRPYAigLNEVQVGLiAPEGIQRLLRRAV 157
Cdd:PRK07827  84 VARAREMTALLRAIVELPKPVIAAIDGHVRAGGFGLVGACDIVV----AGPESTFA--LTEARIGV-APAIISLTLLPRL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLVDELAEGdlvVARAVAWLQNLLRQPR-QPMLLTRAIARADLHEALHPDLIQLDRF 236
Cdd:PRK07827 157 SPRAAARYYLTGEKFGAAEAARIGLVTAAADD---VDAAVAALLADLRRGSpQGLAESKALTTAAVLAGFDRDAEELTEE 233
                        250       260
                 ....*....|....*....|
gi 923079478 237 VEAWFA-PDAQNALQALVAR 255
Cdd:PRK07827 234 SARLFVsDEAREGMTAFLQK 253
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
1-225 1.30e-10

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 59.91  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVinHGPIRELRLARPPV-NALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDvphLLSHGDDK-HKL 77
Cdd:PRK08259   3 MSVRVER--NGPVTTVILNRPEVrNAVDGPTAAALADAFrAFDADDAASVAVLWGAGGTFCAGAD---LKAVGTGRgNRL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  78 LDTWNAFFGAVRTLAESriPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrPYAIGLNEVQVGLIaPEGIQRlLRRAV 157
Cdd:PRK08259  78 HPSGDGPMGPSRMRLSK--PVIAAVSGYAVAGGLELALWCDLRVAEEDA----VFGVFCRRWGVPLI-DGGTVR-LPRLI 149
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTR--AIARADLHEA 225
Cdd:PRK08259 150 GHSRAMDLILTGRPVDADEALAIGLANRVVPKGQARAAAEELAAELAAFPQTCLRADRlsALEQWGLPEE 219
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
11-198 1.80e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 59.62  E-value: 1.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  11 GPIRELRLARPPV-NALDTDLCRQLI-HAIELAMAEDAHGIVLSG-SERIFTGGMDVPHL--LSHGDDKHKLLDTWNAFF 85
Cdd:PRK06144  16 GGIARITFNRPAArNAMTWAMYEGLAeICEAIAADPSIRAVVLRGaGDKAFVAGTDIAQFraFSTAEDAVAYERRIDRVL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  86 GAVRTLaesRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYAIGL-NEVQVGLIApegiqrLLRRAVGVHRAGA 164
Cdd:PRK06144  96 GALEQL---RVPTIAAIAGACVGGGAAIAAACDLRIATPSARFGFPIARTLgNCLSMSNLA------RLVALLGAARVKD 166
                        170       180       190
                 ....*....|....*....|....*....|....
gi 923079478 165 LLTTGALVPAEQALQIGLVDELAEGDLVVARAVA 198
Cdd:PRK06144 167 MLFTARLLEAEEALAAGLVNEVVEDAALDARADA 200
PRK06023 PRK06023
crotonase/enoyl-CoA hydratase family protein;
4-255 2.22e-10

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 168351  Cd Length: 251  Bit Score: 59.42  E-value: 2.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   4 LIEVINHGP-IRELRLARP-PVNALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDT 80
Cdd:PRK06023   6 LVERPGAHPgVQVIRFNRPeKKNAITRAMYATMAKALKAADADDAiRAHVFLGTEGCFSAGNDMQDFLAAAMGGTSFGSE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  81 WNAFFGAvrtLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYaiglneVQVGLIAPEGIQRLLRRAVGVH 160
Cdd:PRK06023  86 ILDFLIA---LAEAEKPIVSGVDGLAIGIGTTIHLHCDLTFASPRSLFRTPF------VDLALVPEAGSSLLAPRLMGHQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 161 RAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEALHPDLIQLDRFVEAW 240
Cdd:PRK06023 157 RAFALLALGEGFSAEAAQEAGLIWKIVDEEAVEAETLKAAEELAAKPPQALQIARDLMRGPREDILARIDEEAKHFAARL 236
                        250
                 ....*....|....*
gi 923079478 241 FAPDAQNALQALVAR 255
Cdd:PRK06023 237 KSAEARAAFEAFMRR 251
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
4-198 4.27e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 58.25  E-value: 4.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   4 LIEVINHGPIRELRLARP-PVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLlsHGDDKHKLLDTw 81
Cdd:PRK06072   1 MIKVESREGYAIVTMSRPdKLNALNLEMRNEFISKLkQINADPKIRVVIVTGEGRAFCVGADLSEF--APDFAIDLRET- 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  82 naFFGAVRTLAESRIPVVAAITGHApAGGCV-LALCCDYRVmarsADPSRPYAIGLNevQVGLIAPEGIQRLLRRAVGVh 160
Cdd:PRK06072  78 --FYPIIREIRFSDKIYISAINGVT-AGACIgIALSTDFKF----ASRDVKFVTAFQ--RLGLASDTGVAYFLLKLTGQ- 147
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 923079478 161 RAGALLTTGALVPAEQALQIGLVdELAEGDLVVARAVA 198
Cdd:PRK06072 148 RFYEILVLGGEFTAEEAERWGLL-KISEDPLSDAEEMA 184
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
10-198 4.39e-10

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 58.49  E-value: 4.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  10 HGPIRELRLARPPV-NALDTDLCRQLiHAIELAMAEDAHGIVLSGSERIFTGGMDVPHLLSH--GDDKHKLLdTWNAFFg 86
Cdd:PRK08150   9 DGGVATIGLNRPAKrNALNDGLIAAL-RAAFARLPEGVRAVVLHGEGDHFCAGLDLSELRERdaGEGMHHSR-RWHRVF- 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  87 avRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVmarsADPSRPYAigLNEVQVGLIAPEGIQRLLRRAVGVHRAGALL 166
Cdd:PRK08150  86 --DKIQYGRVPVIAALHGAVVGGGLELASAAHIRV----ADESTYFA--LPEGQRGIFVGGGGSVRVPRLIGVARMTDMM 157
                        170       180       190
                 ....*....|....*....|....*....|..
gi 923079478 167 TTGALVPAEQALQIGLVDELAEGDLVVARAVA 198
Cdd:PRK08150 158 LTGRVYDAQEGERLGLAQYLVPAGEALDKAME 189
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
10-190 7.35e-10

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 58.03  E-value: 7.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  10 HGPIRELRLARPP-VNALDTDLCRQLIHAIElAMAEDAHG--IVLSGSERIFTGGMDVPHLLSHGDdkhklLDTWNAFFG 86
Cdd:PRK08139  18 RDGVATLTLNRPQaFNALSEAMLAALQAALD-AIAADPSVrvVVLAAAGKAFCAGHDLKEMRAARG-----LAYFRALFA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  87 A----VRTLAESRIPVVAAITGHAPAGGCVLALCCDyrvMARSADPSRpyaIGLNEVQVGL------IApegiqrlLRRA 156
Cdd:PRK08139  92 RcsrvMQAIVALPQPVIARVHGIATAAGCQLVASCD---LAVAADTAR---FAVPGVNIGLfcstpmVA-------LSRN 158
                        170       180       190
                 ....*....|....*....|....*....|....
gi 923079478 157 VGVHRAGALLTTGALVPAEQALQIGLVDELAEGD 190
Cdd:PRK08139 159 VPRKQAMEMLLTGEFIDAATAREWGLVNRVVPAD 192
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
24-190 7.84e-10

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 57.73  E-value: 7.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  24 NALDTDLCRQLIHAIELAMAEDAHGIVLS--GSERIFTGGMDVPHLLSHGDDKhklLDTWNAFFGAVRTLAESRIPVVAA 101
Cdd:PRK11423  26 NALSKVLIDDLMQALSDLNRPEIRVVILRapSGSKVWSAGHDIHELPSGGRDP---LSYDDPLRQILRMIQKFPKPVIAM 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 102 ITGHAPAGGCVLALCCDYRVmarsADPSRPYAIglNEVQVGLiaPEGIQRLLR--RAVGVHRAGALLTTGALVPAEQALQ 179
Cdd:PRK11423 103 VEGSVWGGAFELIMSCDLII----AASTSTFAM--TPANLGV--PYNLSGILNftNDAGFHIVKEMFFTASPITAQRALA 174
                        170
                 ....*....|.
gi 923079478 180 IGLVDELAEGD 190
Cdd:PRK11423 175 VGILNHVVEVE 185
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
1-255 3.48e-09

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 55.92  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPP-VNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGS-ERIFTGGMDV---PHLLSHGDDk 74
Cdd:PRK05980   1 MTDTVLIEIRDGIALLTLNRPEkLNALNYALIDRLLARLdAIEVDESVRAVILTGAgDRAFSAGADIhefSASVAAGAD- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  75 HKLLDTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPyaiglnEVQVGLIAPEGIQRLLR 154
Cdd:PRK05980  80 VALRDFVRRGQAMTARLEAFPKPVIAAVNGLAFGGGCEITEAVHLAIASERALFAKP------EIRLGMPPTFGGTQRLP 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 155 RAVGVHRAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPrqPMLLT---RAIARA---DLHEALhp 228
Cdd:PRK05980 154 RLAGRKRALELLLTGDAFSAERALEIGLVNAVVPHEELLPAARALARRIIRHS--PVAVAailTAVTRGlnlSIAEGL-- 229
                        250       260
                 ....*....|....*....|....*..
gi 923079478 229 dLIQLDRFVEAWFAPDAQNALQALVAR 255
Cdd:PRK05980 230 -LIESEQFARMAGSADLREGLAAWIER 255
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
4-198 5.23e-09

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 55.68  E-value: 5.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   4 LIEVINHGPIRELRLARPP-VNALDTDLCRQLIHAIE-LAMAEDAHGIVLSGSERIFTGGMDVPHLLS---------HGD 72
Cdd:PLN02664   9 IIQKSPNSSVFHLNLNRPSqRNALSLDFFTEFPKALSsLDQNPNVSVIILSGAGDHFCSGIDLKTLNSiseqsssgdRGR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  73 DKHKLLDTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSrpyaigLNEVQVGLIAPEGIQRL 152
Cdd:PLN02664  89 SGERLRRKIKFLQDAITAIEQCRKPVIAAIHGACIGGGVDIVTACDIRYCSEDAFFS------VKEVDLAITADLGTLQR 162
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 923079478 153 LRRAVGVHRAGALLTTGALVPAEQALQIGLV-------DELAEGDLVVARAVA 198
Cdd:PLN02664 163 LPSIVGYGNAMELALTGRRFSGSEAKELGLVsrvfgskEDLDEGVRLIAEGIA 215
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
24-124 9.54e-09

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 54.59  E-value: 9.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  24 NALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLLS--HGDDKHKLLDTWNAFFgavrtlaESRIPVVA 100
Cdd:PRK07110  27 NAFSDELCDQLHEAFdTIAQDPRYKVVILTGYPNYFATGGTQEGLLSlqTGKGTFTEANLYSLAL-------NCPIPVIA 99
                         90       100
                 ....*....|....*....|....
gi 923079478 101 AITGHAPAGGCVLALCCDYRVMAR 124
Cdd:PRK07110 100 AMQGHAIGGGLVLGLYADIVVLSR 123
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
1-220 3.98e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 53.04  E-value: 3.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   1 MTTLIEVINHGPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDV-------------- 64
Cdd:PRK08290   2 EYEYVRYEVAGRIARITLNRPEArNAQNRQMLYELDAAFRRAEADDAvRVIVLAGAGKHFSAGHDLgsgtpgrdrdpgpd 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  65 --PHLLSHGDDK----HKLLDTWNAFFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYA-IGLN 137
Cdd:PRK08290  82 qhPTLWWDGATKpgveQRYAREWEVYLGMCRRWRDLPKPTIAQVQGACIAGGLMLAWVCDLIVASDDAFFSDPVVrMGIP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 138 EVQVgLIAPegiqrllrRAVGVHRAGALLTTGALVPAEQALQIGLV------DELAEGDLVVARAVAwlqnllRQPRQPM 211
Cdd:PRK08290 162 GVEY-FAHP--------WELGPRKAKELLFTGDRLTADEAHRLGMVnrvvprDELEAETLELARRIA------AMPPFGL 226
                        250
                 ....*....|
gi 923079478 212 LLT-RAIARA 220
Cdd:PRK08290 227 RLTkRAVNQT 236
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
16-190 1.69e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 50.89  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  16 LRLARPPV-NALDTDLCRQLIHAIELAmAEDA--HGIVLSGSERIFTGGMDVPHLLS--HGDDKHKLLDTW---NAFFGA 87
Cdd:PRK07260  15 LTLNRPEVsNGFNIPMCQEILEALRLA-EEDPsvRFLLINANGKVFSVGGDLVEMKRavDEDDVQSLVKIAelvNEISFA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  88 VRTLAEsriPVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYaiglneVQVGLIAPEGIQRLLRRAVGVHRAGALLT 167
Cdd:PRK07260  94 IKQLPK---PVIMCVDGAVAGAAANMAVAADFCIASTKTKFIQAF------VGVGLAPDAGGLFLLTRAIGLNRATHLAM 164
                        170       180
                 ....*....|....*....|...
gi 923079478 168 TGALVPAEQALQIGLVDELAEGD 190
Cdd:PRK07260 165 TGEALTAEKALEYGFVYRVAESE 187
PRK07112 PRK07112
enoyl-CoA hydratase/isomerase;
5-184 2.23e-07

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235938  Cd Length: 255  Bit Score: 50.45  E-value: 2.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478   5 IEVINHGPIRELRLARPPV-NALDTDLCRQLIHAIELaMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDTWNA 83
Cdd:PRK07112   6 IRVRQQGDVCFLQLHRPEAqNTINDRLIAECMDVLDR-CEHAATIVVLEGLPEVFCFGADFSAIAEKPDAGRADLIDAEP 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  84 FFGAVRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVmarsADPSRPYaiGLNEVQVGLIaPEGIQRLLRRAVGVHRAG 163
Cdd:PRK07112  85 LYDLWHRLATGPYVTIAHVRGKVNAGGIGFVAASDIVI----ADETAPF--SLSELLFGLI-PACVLPFLIRRIGTQKAH 157
                        170       180
                 ....*....|....*....|.
gi 923079478 164 ALLTTGALVPAEQALQIGLVD 184
Cdd:PRK07112 158 YMTLMTQPVTAQQAFSWGLVD 178
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
24-185 2.96e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 50.09  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  24 NALDTDLCRQLIHAIELAMAEDA-HGIVLSGS-ERIFTGGMDVPHLLSHGDDKHKLLDTWNAFFGAVRTLAESRIPVVAA 101
Cdd:PRK06127  33 NAMSLDMWEALPQALAAAEDDDAiRVVVLTGAgEKAFVSGADISQFEESRSDAEAVAAYEQAVEAAQAALADYAKPTIAC 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 102 ITGHAPAGGCVLALCCDYRVMARSADPSRPYAiglnevQVGL-IAPEGIQRLLrRAVGVHRAGALLTTGALVPAEQALQI 180
Cdd:PRK06127 113 IRGYCIGGGMGIALACDIRIAAEDSRFGIPAA------RLGLgYGYDGVKNLV-DLVGPSAAKDLFYTARRFDAAEALRI 185

                 ....*
gi 923079478 181 GLVDE 185
Cdd:PRK06127 186 GLVHR 190
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
11-183 1.85e-06

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 47.79  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  11 GPIRELRLARPPV-NALDTDLCRQLIHAIELAMAEDA-HGIVLSGSERIFTGGMDVPHLLSHGDDkhkllDTWNAffgav 88
Cdd:PRK07799  13 GHTLIVTMNRPEArNALSTEMLRIMVDAWDRVDNDPDiRSCILTGAGGAFCAGMDLKAATKKPPG-----DSFKD----- 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  89 RTLAESRI-----------PVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAV 157
Cdd:PRK07799  83 GSYDPSRIdallkgrrltkPLIAAVEGPAIAGGTEILQGTDIRVAGESA------KFGISEAKWSLFPMGGSAVRLVRQI 156
                        170       180
                 ....*....|....*....|....*.
gi 923079478 158 GVHRAGALLTTGALVPAEQALQIGLV 183
Cdd:PRK07799 157 PYTVACDLLLTGRHITAAEAKEIGLI 182
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
10-255 1.57e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 44.95  E-value: 1.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  10 HGPIRELRLARP-PVNALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLL-----DTWn 82
Cdd:PRK06563   6 RGHVLLIGLDRPaKRNAFDSAMLDDLALALgEYEADDELRVAVLFAHGEHFTAGLDLADVAPKLAAGGFPFpeggiDPW- 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  83 AFFGAVRTLaesriPVVAAITGHAPAGGCVLALCCDYRVMARSADpsrpyaIGLNEVQVGlIAPEG--IQRLLRRAvGVH 160
Cdd:PRK06563  85 GTVGRRLSK-----PLVVAVQGYCLTLGIELMLAADIVVAADNTR------FAQLEVQRG-ILPFGgaTLRFPQAA-GWG 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 161 RAGALLTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARADLHEALHPDLIQLDRFVEAW 240
Cdd:PRK06563 152 NAMRYLLTGDEFDAQEALRLGLVQEVVPPGEQLERAIELAERIARAAPLGVQATLASARAAVREGEAAAAAQLPPELRPL 231
                        250
                 ....*....|....*.
gi 923079478 241 FAP-DAQNALQALVAR 255
Cdd:PRK06563 232 FTSeDAKEGVQAFLER 247
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
16-255 2.00e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 44.67  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  16 LRLARPPV-NALDTDLCRQLIHAIE-LAMAEDAHGIVLSGSERIFTGGMDV----PHLLSHGDDKHKLLDTWNAFFGAVR 89
Cdd:PRK07468  18 LTLNRPEKhNALSARMIAELTTAARrLAADAAVRVVVLTGAGKSFCAGGDLgwmrAQMTADRATRIEEARRLAMMLKALN 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  90 TLAEsriPVVAAITGHAPAGGCVLALCCDyrvMARSADPSRpyaIGLNEVQVGLIaPEGIQRLLRRAVGVHRAGALLTTG 169
Cdd:PRK07468  98 DLPK---PLIGRIQGQAFGGGVGLISVCD---VAIAVSGAR---FGLTETRLGLI-PATISPYVVARMGEANARRVFMSA 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478 170 ALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQPRQPMLLTRAIARAdLHEALHPDLIQ--LDRFVEAWFAPDAQN 247
Cdd:PRK07468 168 RLFDAEEAVRLGLLSRVVPAERLDAAVEAEVTPYLSCAPGAVAAAKALVRA-LGAPIDEAVIDatIEALADTWETEEARE 246

                 ....*...
gi 923079478 248 ALQALVAR 255
Cdd:PRK07468 247 GIAAFFDK 254
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
99-240 2.82e-05

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 44.52  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  99 VAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLTTGALVPAEQAL 178
Cdd:PRK08788 125 IALVQGDALGGGFEAALSHHTIIAERGA------KMGFPEILFNLFPGMGAYSFLARRVGPKLAEELILSGKLYTAEELH 198
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 923079478 179 QIGLVDELAE-GDLVVArAVAWLQNLLRQPRQpmllTRAIARADlHEALHPDLIQLDRFVEAW 240
Cdd:PRK08788 199 DMGLVDVLVEdGQGEAA-VRTFIRKSKRKLNG----WRAMLRAR-RRVNPLSLEELMDITEIW 255
Clp_protease_like cd00394
Caseinolytic protease (ClpP) is an ATP-dependent protease; Clp protease (caseinolytic protease; ...
88-186 4.54e-04

Caseinolytic protease (ClpP) is an ATP-dependent protease; Clp protease (caseinolytic protease; ClpP; endopeptidase Clp; Peptidase S14; ATP-dependent protease, ClpAP)-like enzymes are highly conserved serine proteases and belong to the ClpP/Crotonase superfamily. Included in this family are Clp proteases that are involved in a number of cellular processes such as degradation of misfolded proteins, regulation of short-lived proteins and housekeeping removal of dysfunctional proteins. They are also implicated in the control of cell growth, targeting DNA-binding protein from starved cells. The functional Clp protease is comprised of two components: a proteolytic component and one of several regulatory ATPase components, both of which are required for effective levels of protease activity in the presence of ATP. Active site consists of the triad Ser, His and Asp, preferring hydrophobic or non-polar residues at P1 or P1' positions. The protease exists as a tetradecamer made up of two heptameric rings stacked back-to-back such that the catalytic triad of each subunit is located at the interface between three monomers, thus making oligomerization essential for function. Another family included in this class of enzymes is the signal peptide peptidase A (SppA; S49) which is involved in the cleavage of signal peptides after their removal from the precursor proteins by signal peptidases. Mutagenesis studies suggest that the catalytic center of SppA comprises a Ser-Lys dyad and not the usual Ser-His-Asp catalytic triad found in the majority of serine proteases. In addition to the carboxyl-terminal protease domain that is conserved in all the S49 family members, the E. coli SppA contains an amino-terminal domain. Others, including sohB peptidase, protein C, protein 1510-N and archaeal signal peptide peptidase, do not contain the amino-terminal domain. The third family included in this hierarchy is nodulation formation efficiency D (NfeD) which is a membrane-bound Clp-class protease and only found in bacteria and archaea. Majority of the NfeD genomes have been shown to possess operons containing a homologous NfeD/stomatin gene pair, causing NfeD to be previously named stomatin operon partner protein (STOPP). NfeD homologs can be divided into two groups: long and short forms. Long-form homologs have a putative ClpP-class serine protease domain while the short form homologs do not. Downstream from the ClpP-class domain is the so-called NfeD or DUF107 domain. N-terminal region of the NfeD homolog PH1510 from Pyrococcus horikoshii has been shown to possess serine protease activity having a Ser-Lys catalytic dyad.


Pssm-ID: 132923 [Multi-domain]  Cd Length: 161  Bit Score: 39.68  E-value: 4.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  88 VRTLAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSA--DPSRPYAIGLN--EVQVGLIAPEGIQRLLRR---AVGVH 160
Cdd:cd00394   50 VDALQASRKPVIAYVGGQAASAGYYIATAANKIVMAPGTrvGSHGPIGGYGGngNPTAQEADQRIILYFIARfisLVAEN 129
                         90       100       110
                 ....*....|....*....|....*....|..
gi 923079478 161 RAGAL------LTTGALVPAEQALQIGLVDEL 186
Cdd:cd00394  130 RGQTTekleedIEKDLVLTAQEALEYGLVDAL 161
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
13-203 9.33e-04

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 39.62  E-value: 9.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  13 IRELRLARPPV-NALDTDLCRQLIHAI-ELAMAEDAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDTWNAFFGAVRT 90
Cdd:PRK07327  22 VLEIVLNGPGAlNAADARMHRELADIWrDVDRDPDVRVVLIRGEGKAFSAGGDLALVEEMADDFEVRARVWREARDLVYN 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  91 LAESRIPVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEG---IQRLLrraVGVHRAGALLT 167
Cdd:PRK07327 102 VINCDKPIVSAIHGPAVGAGLVAALLADISIAAKDA------RIIDGHTRLGVAAGDHaaiVWPLL---CGMAKAKYYLL 172
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 923079478 168 TGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNL 203
Cdd:PRK07327 173 LCEPVSGEEAERIGLVSLAVDDDELLPKALEVAERL 208
PLN02921 PLN02921
naphthoate synthase
97-205 1.94e-03

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 39.00  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  97 PVVAAITGHAPAGGCVLALCCDYRVMARSAdpsrpyAIGLNEVQVGLIAPEGIQRLLRRAVGVHRAGALLTTGALVPAEQ 176
Cdd:PLN02921 163 PVIAMVAGYAVGGGHILHMVCDLTIAADNA------VFGQTGPKVGSFDAGYGSSIMARLVGQKKAREMWFLARFYTASE 236
                         90       100
                 ....*....|....*....|....*....
gi 923079478 177 ALQIGLVDELAEGDLVVARAVAWLQNLLR 205
Cdd:PLN02921 237 ALKMGLVNTVVPLDELEGETVKWCREILR 265
PRK12478 PRK12478
crotonase/enoyl-CoA hydratase family protein;
11-207 4.07e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 183548  Cd Length: 298  Bit Score: 38.01  E-value: 4.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  11 GPIRELRLARPP-VNALDTDLCRQLIHAIELAMAE-DAHGIVLSGSERIFTGGMDVPHLLSHGDDKHKLLDTWN-----A 83
Cdd:PRK12478  13 GPVATITLNRPEqLNTIVPPMPDEIEAAIGLAERDqDIKVIVLRGAGRAFSGGYDFGGGFQHWGEAMMTDGRWDpgkdfA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 923079478  84 FFGAVRTLAESRI--------PVVAAITGHAPAGGCVLALCCDYRVMARSADPSRPYAIGLNEVQVGLiapeGIQRLLRR 155
Cdd:PRK12478  93 MVTARETGPTQKFmaiwraskPVIAQVHGWCVGGASDYALCADIVIASDDAVIGTPYSRMWGAYLTGM----WLYRLSLA 168
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 923079478 156 AVGVHRagallTTGALVPAEQALQIGLVDELAEGDLVVARAVAWLQNLLRQP 207
Cdd:PRK12478 169 KVKWHS-----LTGRPLTGVQAAEAELINEAVPFERLEARVAEVATELARIP 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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