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Conserved domains on  [gi|924506223|ref|WP_053512464|]
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MULTISPECIES: penicillin-binding protein [Bacillus cereus group]

Protein Classification

penicillin-binding protein( domain architecture ID 11433624)

PASTA domain-containing penicillin-binding protein may catalyze key steps in the synthesis of peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains

Gene Ontology:  GO:0008658|GO:0016020|GO:0009252
PubMed:  32762868|32442851

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 13-559 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 553.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  13 ARFFYIQstgTVHNQDLDALAKQKHSKKGVLEANRGTIYDQNGHVLAQDANSYKMVAALKganSVENKEDTAKKIAGVLG 92
Cdd:COG0768   30 GRLFYLQ---VVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADPE---EVKDPEETAEKLAKLLG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  93 KGEEDILASLNKEGRSQVefgTLGKDLTKEKKEQIEALKLPGISFITENARVYPNGDFASYVIGHAKPNENGTSVGQFGI 172
Cdd:COG0768  104 LDPEELRKKLKKKSRFPV---YLKRNLSPEEAARIRALKLPGVYVEAEYKRYYPYGELAAHVLGYVGEINGGDGIGKSGL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 173 EKSLDKYLSASNGEVAYTGDRKGVSLDGGKVnVKAPKNGDNAYLTIDQRVQSYLEDAMKAASKQYEPESLIGIVADPKTG 252
Cdd:COG0768  181 EKAYEDLLRGTPGKRRVEVDARGRVIRDLGE-EKPPVPGKDLVLTIDSDLQKIAEEALKKAVEEYKAKSGAVVVMDPKTG 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 253 KILAMSTKPSYDPNDRQ---IKYFFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQD-YYQSGTYQVGNRKIKDHNGGaG 328
Cdd:COG0768  260 EILAMASYPSFDPNLFVggpDEPLRNRAVQGTYEPGSTFKPFTAAAALEEGVITPDTtFDCPGYYRVGGRTIRDWDRG-G 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 329 WGSITFDEGVERSSNVAFAILGdQKLGPERFRKYIHSFGLDEKTNIDLSGEgSNTILFDQQ----IQQVTTAFGQGSTVT 404
Cdd:COG0768  339 HGTLTLTEALAKSSNVGFYKLA-LRLGIDKLYDYLKKFGLGQKTGIDLPGE-ASGLLPSPKrwypGETATMSIGQGLSVT 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 405 PIQLVQAATAIANDGKMMKPYAIDKIVDPITDKVKLEhkPEEVGKPVTKETAAQVRQLLESVVTSPKGTGTAYKIDGYSV 484
Cdd:COG0768  417 PLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEE--PEVLRRVISPETAETVREGMEGVVNEPGGTARRAAIPGYRV 494

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 924506223 485 GGKTGTAQIPD-GKGGYMTGRqnYIFSFLGMAPMDDPQLVVYVAVKQPklKDDENGAQPLADIFKYVTKNSLEYLK 559
Cdd:COG0768  495 AGKTGTAQVVDiGNGGYYKGR--HIASFVGFAPADNPRYAVAVVVENP--GGGAYGGTVAAPVFREIMEAYLRLLG 566
PASTA_Pbp2x-like_2 cd06575
PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the ...
 634-686 9.30e-16

PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


:

Pssm-ID: 119326 [Multi-domain]  Cd Length: 54  Bit Score: 71.71  E-value: 9.30e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 924506223 634 TMPNIQGWALRDVMNLAKTLQLNLKPSGTGYVTEQSVAEGTLLQPGTELGVTL 686
Cdd:cd06575    1 TMPDLTGWSKRDALKLLELLGLKVKFSGSGYVVSQSIAPGTKVKKGTTITVTL 53
PASTA_Pbp2x-like_1 cd06576
PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the ...
 578-631 4.36e-11

PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


:

Pssm-ID: 119327 [Multi-domain]  Cd Length: 55  Bit Score: 58.29  E-value: 4.36e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 924506223 578 TVPDVNGKTMAEAGKAIDKAKLRPIVLGEG-KVQQQVPKATEQTLKGDRVFLVGD 631
Cdd:cd06576    1 KVPDVTGKSVEEAKKELKEAGLQPVVIGNGkKVKKQSPKPGEKVLEGSKVLLYTD 55
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 13-559 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 553.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  13 ARFFYIQstgTVHNQDLDALAKQKHSKKGVLEANRGTIYDQNGHVLAQDANSYKMVAALKganSVENKEDTAKKIAGVLG 92
Cdd:COG0768   30 GRLFYLQ---VVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADPE---EVKDPEETAEKLAKLLG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  93 KGEEDILASLNKEGRSQVefgTLGKDLTKEKKEQIEALKLPGISFITENARVYPNGDFASYVIGHAKPNENGTSVGQFGI 172
Cdd:COG0768  104 LDPEELRKKLKKKSRFPV---YLKRNLSPEEAARIRALKLPGVYVEAEYKRYYPYGELAAHVLGYVGEINGGDGIGKSGL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 173 EKSLDKYLSASNGEVAYTGDRKGVSLDGGKVnVKAPKNGDNAYLTIDQRVQSYLEDAMKAASKQYEPESLIGIVADPKTG 252
Cdd:COG0768  181 EKAYEDLLRGTPGKRRVEVDARGRVIRDLGE-EKPPVPGKDLVLTIDSDLQKIAEEALKKAVEEYKAKSGAVVVMDPKTG 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 253 KILAMSTKPSYDPNDRQ---IKYFFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQD-YYQSGTYQVGNRKIKDHNGGaG 328
Cdd:COG0768  260 EILAMASYPSFDPNLFVggpDEPLRNRAVQGTYEPGSTFKPFTAAAALEEGVITPDTtFDCPGYYRVGGRTIRDWDRG-G 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 329 WGSITFDEGVERSSNVAFAILGdQKLGPERFRKYIHSFGLDEKTNIDLSGEgSNTILFDQQ----IQQVTTAFGQGSTVT 404
Cdd:COG0768  339 HGTLTLTEALAKSSNVGFYKLA-LRLGIDKLYDYLKKFGLGQKTGIDLPGE-ASGLLPSPKrwypGETATMSIGQGLSVT 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 405 PIQLVQAATAIANDGKMMKPYAIDKIVDPITDKVKLEhkPEEVGKPVTKETAAQVRQLLESVVTSPKGTGTAYKIDGYSV 484
Cdd:COG0768  417 PLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEE--PEVLRRVISPETAETVREGMEGVVNEPGGTARRAAIPGYRV 494

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 924506223 485 GGKTGTAQIPD-GKGGYMTGRqnYIFSFLGMAPMDDPQLVVYVAVKQPklKDDENGAQPLADIFKYVTKNSLEYLK 559
Cdd:COG0768  495 AGKTGTAQVVDiGNGGYYKGR--HIASFVGFAPADNPRYAVAVVVENP--GGGAYGGTVAAPVFREIMEAYLRLLG 566
spoVD_pbp TIGR02214
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ...
 14-628 6.38e-141

stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]


Pssm-ID: 131269 [Multi-domain]  Cd Length: 636  Bit Score: 426.54  E-value: 6.38e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223   14 RFFYIQstgTVHNQDLDALAKQKHSKKGVLEANRGTIYDQNGHVLAQDANSYKMVAALKGANSVENKEDT--AKKIAGVL 91
Cdd:TIGR02214  19 RLFYVQ---VFRGSFYKEMAEDQWTREIPIEAKRGRILDRNGNELAVSVSVDRVDLDPATIRKNKEPKQReiANELARVL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223   92 GKGEEDILASLNKEgRSQVEFGTLGKDLTKEKKEQIEALKLPGISFITENARVYPNGDFASYVIGHAKPNENGTSvgqfG 171
Cdd:TIGR02214  96 EMDKEKVFKRITKK-NSPFVSAKLGRKIEKDKAEKVRNLKLNGVSVSPDSKRYYPNGDFLSHVLGFTNSDGRGLE----G 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  172 IEKSLDKYLSASNGEVAYTGDRKGVSLDGGKVNVKAPKNGDNAYLTIDQRVQSYLEDAMKAASKQYEPESLIGIVADPKT 251
Cdd:TIGR02214 171 LELYYDKELRGLPGVRVAEYDANSLELPYAQHAYVKPVDGHDLVLTIDENIQYIIEREADKALRERKPKGVSIIVMNPKN 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  252 GKILAMSTKPSYDPNDRQIKY----FFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQD-YYQSGTYQVGNRKIKDHNGG 326
Cdd:TIGR02214 251 GEILGMSNRPTYDPNDPRDKSpdtaRRNRAVSDAYEPGSTFKIITSSAAMEEGIVKESDkFYDDGSATVGGKKIKCWKPG 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  327 aGWGSITFDEGVERSSNVAFAILGDqKLGPERFRKYIHSFGLDEKTNIDLSGEGSNtILFDQQ----IQQVTTAFGQGST 402
Cdd:TIGR02214 331 -GHGSQTFPEVVQNSCNPGFIELGM-RLGAEKLNNYILAFGFGSKTGIDLPGEAAG-ILVPKKkvgpVDLATISFGQANT 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  403 VTPIQLVQAATAIANDGKMMKPYAIDKIVDPITDKVKLEHKPEEVGKPVTKETAAQVRQLLESVVTspKGTGTAYKIDGY 482
Cdd:TIGR02214 408 VTPIQLMTAVNAVANGGKLIQPHIMKEISDSQNNAVDQTFEPEVKRQVVSKETTQKLRLALETVVS--KGSGKNAFIEGY 485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  483 SVGGKTGTAQIPDGKGGYMTGrqNYIFSFLGMAPMDDPQLVVYVAVKQPKlKDDENGAQPLADIFKYVTKNSLEYLKIKP 562
Cdd:TIGR02214 486 RVGGKTGTAQKVKPNGGYMEG--EYIVSFVGFAPADDPAVAVLVVVDNPK-GVQQFGGLVAAPVFGSVFNDILNYLGIKP 562

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  563 --NEVKDPKKHLKEQQTT-VPDVNGKTMAEAGKAIDKAKLRPIVLGEG-KVQQQVPKATEQTLKGDRVFL 628
Cdd:TIGR02214 563 qmNQGEAPAAATNQVEAVaVPNLRGMKVDDAEKTLLHLGLDVATEGFGtRVVNQTPIPGEKVKEGTKVVL 632
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 245-544 1.30e-78

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 253.11  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  245 IVADPKTGKILAMSTKPSYDPNDRqIKYFFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQDYYQSGTY-QVGNRKIKDH 323
Cdd:pfam00905   4 VVLDPKTGEVLAMVGKPSYDPNGF-IGPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWPGkQQGGKSIGDW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  324 NGGaGWGSITFDEGVERSSNVAFAILGdQKLGPERFRKYIHSFGLDEKTNIDLSGEgSNTILFDQQIQQVTTAFGQGSTV 403
Cdd:pfam00905  83 NQD-QVGIGTLRQALEYSSNWYMQKLA-QKLGADKLRSYLKKFGYGNKTGIGLPGE-NAGYLTPYWLEGATASFGIGLTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  404 TPIQLVQAATAIANDGKMMKPYAIDKIVDPITDKVKlehkpeeVGKPVTKETAAQVRQLLESVVTSPKGTGTAyKIDGYS 483
Cdd:pfam00905 160 TPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVL-------NKLPISKSTAEKVKDMLRLVVNDGTGTGTA-AVPGYK 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 924506223  484 VGGKTGTAQI-PDGKGGYMTGrqNYIFSFLGMAPMDDPQLVVYVAVKQPKLKDDENGAQPLA 544
Cdd:pfam00905 232 VAGKTGTAQVaGPKGGGYYDG--AQIGWFVGYAPADNPKYAFAVLIDDPKRYYGGKVAAPIF 291
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 101-563 4.28e-47

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 175.78  E-value: 4.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 101 SLNKEGRsqveFGTLGKDLTKEKKEQIEALKLPGISFITENARVYPNGDFASYVIGHAkpneNGTSVGQFGIEKSLDKYL 180
Cdd:PRK15105 128 NANPKGR----FIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFT----NVDSQGIEGVEKSFDKWL 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 181 SASNGEVAYTGDRKG-VSLDGGKVNVKApknGDNAYLTIDQRVQSYLEDAMKAASKQYEPESLIGIVADPKTGKILAMST 259
Cdd:PRK15105 200 TGQPGERIVRKDRYGrVIEDISSTDSQA---AHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMAN 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 260 KPSYDPNDR---QIKYFFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQDYYQSGTYQVGNRKIKDhngGAGWGSITFDE 336
Cdd:PRK15105 277 SPSYNPNNLsgtPKDAMRNRAITDVFEPGSTVKPMVVMTALQRGVVKENSVLNTVPYRINGHEIKD---VARYSELTLTG 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 337 GVERSSNVAFAILGDQKLGPERFRKYiHSFGLDEKTNIDLSGEGSNtiLFDQQ-----IQQVTTAFGQGSTVTPIQLVQA 411
Cdd:PRK15105 354 VLQKSSNVGVSKLALAMPSSALVDTY-SRFGLGKATNLGLVGERSG--LYPQKqrwsdIERATFSFGYGLMVTPLQLARV 430

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 412 ATAIANDGkMMKPYAIDKiVDPITDKVKLehKPEEVGKPVTketaaqvrQLLESVVTsPKGTGTAYKIDGYSVGGKTGTA 491
Cdd:PRK15105 431 YATIGSYG-IYRPLSITK-VDPPVPGERV--FPESIVRTVV--------HMMESVAL-PGGGGVKAAIKGYRIAIKTGTA 497

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 924506223 492 QI--PDGKggYMTgrqNYIFSFLGMAPMDDPQLVVYVAVKQPKLKDDENGAQPlADIFKYVTKNSLEYLKIKPN 563
Cdd:PRK15105 498 KKvgPDGR--YIN---KYIAYTAGVAPASQPRFALVVVINDPQAGKYYGGAVS-APVFGAIMGGVLRTMNIEPD 565
PASTA_Pbp2x-like_2 cd06575
PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the ...
 634-686 9.30e-16

PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119326 [Multi-domain]  Cd Length: 54  Bit Score: 71.71  E-value: 9.30e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 924506223 634 TMPNIQGWALRDVMNLAKTLQLNLKPSGTGYVTEQSVAEGTLLQPGTELGVTL 686
Cdd:cd06575    1 TMPDLTGWSKRDALKLLELLGLKVKFSGSGYVVSQSIAPGTKVKKGTTITVTL 53
PASTA_Pbp2x-like_1 cd06576
PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the ...
 578-631 4.36e-11

PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119327 [Multi-domain]  Cd Length: 55  Bit Score: 58.29  E-value: 4.36e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 924506223 578 TVPDVNGKTMAEAGKAIDKAKLRPIVLGEG-KVQQQVPKATEQTLKGDRVFLVGD 631
Cdd:cd06576    1 KVPDVTGKSVEEAKKELKEAGLQPVVIGNGkKVKKQSPKPGEKVLEGSKVLLYTD 55
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
575-687 1.13e-09

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 61.35  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 575 QQTTVPDVNGKTMAEAGKAIDKAKLRPIVLGE--------GKVQQQVPKATEQTLKGDRVFLV----GDKPTMPNIQGWA 642
Cdd:NF033483 363 KEVTVPDVVGKTEAEAKEALEKAGLKVGKVEEeysddveeGKVISTDPEAGTRVKEGSTVTLVvskgPEKVKVPDLTGKS 442

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 924506223 643 LRDVMNLAKTLQLNLKPSGT--------GYVTEQSVAEGTLLQPGTElgVTLV 687
Cdd:NF033483 443 LDEAKKALEDAGLKVGTIEEeysddvpkGTVISQDPAAGTEVDKGTT--VTLT 493
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
575-687 3.53e-08

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 56.73  E-value: 3.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 575 QQTTVPDVNGKTMAEAGKAIDKAKLRPIVLGE--------GKVQQQVPKATEQTLKGDRVFLV---GDKP-TMPNIQGWA 642
Cdd:NF033483 431 EKVKVPDLTGKSLDEAKKALEDAGLKVGTIEEeysddvpkGTVISQDPAAGTEVDKGTTVTLTvskGPEPvTVPDVTGMS 510

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 924506223 643 LRDVMNLAKTLQLNLK----------PSGTgyVTEQSVAEGTLLQPGTElgVTLV 687
Cdd:NF033483 511 EEEAKSALESAGLKVGveeeevssdvPAGT--VISQSPAAGTEVAKGST--VTLT 561
PASTA pfam03793
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ...
 577-629 2.82e-05

PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 461053 [Multi-domain]  Cd Length: 63  Bit Score: 42.22  E-value: 2.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  577 TTVPDVNGKTMAEAGKAIDKAKLR-------PIVLGEGKVQQQVPKATEQTLKGDRVFLV 629
Cdd:pfam03793   1 VTVPDVVGLSLEEAKKLLEALGLKvgtveeySDDVGEGTVISQSPPAGTKVKKGSKVTLT 60
PASTA pfam03793
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ...
 634-686 6.83e-05

PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 461053 [Multi-domain]  Cd Length: 63  Bit Score: 41.07  E-value: 6.83e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  634 TMPNIQGWALRDVMNLAKTLQLNLK-------PSGTGYVTEQSVAEGTLLQPGTELGVTL 686
Cdd:pfam03793   2 TVPDVVGLSLEEAKKLLEALGLKVGtveeysdDVGEGTVISQSPPAGTKVKKGSKVTLTV 61
PASTA smart00740
PASTA domain;
573-629 4.10e-04

PASTA domain;


Pssm-ID: 197851 [Multi-domain]  Cd Length: 67  Bit Score: 39.21  E-value: 4.10e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 924506223   573 KEQQTTVPDVNGKTMAEAGKAIDKAKLRPIVL-------GEGKVQQQVPKATEQTLKGDRVFLV 629
Cdd:smart00740   1 GPEKVEVPDVIGKSKEEAKKLLKALGLKVEVVeeyssdgEEGTVISQSPAAGTTVKPGSKVTLT 64
 
Name Accession Description Interval E-value
FtsI COG0768
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
 13-559 0e+00

Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440531 [Multi-domain]  Cd Length: 568  Bit Score: 553.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  13 ARFFYIQstgTVHNQDLDALAKQKHSKKGVLEANRGTIYDQNGHVLAQDANSYKMVAALKganSVENKEDTAKKIAGVLG 92
Cdd:COG0768   30 GRLFYLQ---VVEGDEYAELAEENRIRTVPIPAPRGLIYDRNGNVLATNVPVYSLYADPE---EVKDPEETAEKLAKLLG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  93 KGEEDILASLNKEGRSQVefgTLGKDLTKEKKEQIEALKLPGISFITENARVYPNGDFASYVIGHAKPNENGTSVGQFGI 172
Cdd:COG0768  104 LDPEELRKKLKKKSRFPV---YLKRNLSPEEAARIRALKLPGVYVEAEYKRYYPYGELAAHVLGYVGEINGGDGIGKSGL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 173 EKSLDKYLSASNGEVAYTGDRKGVSLDGGKVnVKAPKNGDNAYLTIDQRVQSYLEDAMKAASKQYEPESLIGIVADPKTG 252
Cdd:COG0768  181 EKAYEDLLRGTPGKRRVEVDARGRVIRDLGE-EKPPVPGKDLVLTIDSDLQKIAEEALKKAVEEYKAKSGAVVVMDPKTG 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 253 KILAMSTKPSYDPNDRQ---IKYFFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQD-YYQSGTYQVGNRKIKDHNGGaG 328
Cdd:COG0768  260 EILAMASYPSFDPNLFVggpDEPLRNRAVQGTYEPGSTFKPFTAAAALEEGVITPDTtFDCPGYYRVGGRTIRDWDRG-G 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 329 WGSITFDEGVERSSNVAFAILGdQKLGPERFRKYIHSFGLDEKTNIDLSGEgSNTILFDQQ----IQQVTTAFGQGSTVT 404
Cdd:COG0768  339 HGTLTLTEALAKSSNVGFYKLA-LRLGIDKLYDYLKKFGLGQKTGIDLPGE-ASGLLPSPKrwypGETATMSIGQGLSVT 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 405 PIQLVQAATAIANDGKMMKPYAIDKIVDPITDKVKLEhkPEEVGKPVTKETAAQVRQLLESVVTSPKGTGTAYKIDGYSV 484
Cdd:COG0768  417 PLQLAQAYAAIANGGVLVKPHLVKEIVDPDGEVVKEE--PEVLRRVISPETAETVREGMEGVVNEPGGTARRAAIPGYRV 494

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 924506223 485 GGKTGTAQIPD-GKGGYMTGRqnYIFSFLGMAPMDDPQLVVYVAVKQPklKDDENGAQPLADIFKYVTKNSLEYLK 559
Cdd:COG0768  495 AGKTGTAQVVDiGNGGYYKGR--HIASFVGFAPADNPRYAVAVVVENP--GGGAYGGTVAAPVFREIMEAYLRLLG 566
spoVD_pbp TIGR02214
stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the ...
 14-628 6.38e-141

stage V sporulation protein D; This model describes the spoVD subfamily of homologs of the cell division protein FtsI, a penicillin binding protein. This subfamily is restricted to Bacillus subtilis and related Gram-positive species with known or suspected endospore formation capability. In these species, the functional equivalent of FtsI is desginated PBP-2B, a paralog of spoVD. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan, Cellular processes, Sporulation and germination]


Pssm-ID: 131269 [Multi-domain]  Cd Length: 636  Bit Score: 426.54  E-value: 6.38e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223   14 RFFYIQstgTVHNQDLDALAKQKHSKKGVLEANRGTIYDQNGHVLAQDANSYKMVAALKGANSVENKEDT--AKKIAGVL 91
Cdd:TIGR02214  19 RLFYVQ---VFRGSFYKEMAEDQWTREIPIEAKRGRILDRNGNELAVSVSVDRVDLDPATIRKNKEPKQReiANELARVL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223   92 GKGEEDILASLNKEgRSQVEFGTLGKDLTKEKKEQIEALKLPGISFITENARVYPNGDFASYVIGHAKPNENGTSvgqfG 171
Cdd:TIGR02214  96 EMDKEKVFKRITKK-NSPFVSAKLGRKIEKDKAEKVRNLKLNGVSVSPDSKRYYPNGDFLSHVLGFTNSDGRGLE----G 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  172 IEKSLDKYLSASNGEVAYTGDRKGVSLDGGKVNVKAPKNGDNAYLTIDQRVQSYLEDAMKAASKQYEPESLIGIVADPKT 251
Cdd:TIGR02214 171 LELYYDKELRGLPGVRVAEYDANSLELPYAQHAYVKPVDGHDLVLTIDENIQYIIEREADKALRERKPKGVSIIVMNPKN 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  252 GKILAMSTKPSYDPNDRQIKY----FFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQD-YYQSGTYQVGNRKIKDHNGG 326
Cdd:TIGR02214 251 GEILGMSNRPTYDPNDPRDKSpdtaRRNRAVSDAYEPGSTFKIITSSAAMEEGIVKESDkFYDDGSATVGGKKIKCWKPG 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  327 aGWGSITFDEGVERSSNVAFAILGDqKLGPERFRKYIHSFGLDEKTNIDLSGEGSNtILFDQQ----IQQVTTAFGQGST 402
Cdd:TIGR02214 331 -GHGSQTFPEVVQNSCNPGFIELGM-RLGAEKLNNYILAFGFGSKTGIDLPGEAAG-ILVPKKkvgpVDLATISFGQANT 407

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  403 VTPIQLVQAATAIANDGKMMKPYAIDKIVDPITDKVKLEHKPEEVGKPVTKETAAQVRQLLESVVTspKGTGTAYKIDGY 482
Cdd:TIGR02214 408 VTPIQLMTAVNAVANGGKLIQPHIMKEISDSQNNAVDQTFEPEVKRQVVSKETTQKLRLALETVVS--KGSGKNAFIEGY 485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  483 SVGGKTGTAQIPDGKGGYMTGrqNYIFSFLGMAPMDDPQLVVYVAVKQPKlKDDENGAQPLADIFKYVTKNSLEYLKIKP 562
Cdd:TIGR02214 486 RVGGKTGTAQKVKPNGGYMEG--EYIVSFVGFAPADDPAVAVLVVVDNPK-GVQQFGGLVAAPVFGSVFNDILNYLGIKP 562

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  563 --NEVKDPKKHLKEQQTT-VPDVNGKTMAEAGKAIDKAKLRPIVLGEG-KVQQQVPKATEQTLKGDRVFL 628
Cdd:TIGR02214 563 qmNQGEAPAAATNQVEAVaVPNLRGMKVDDAEKTLLHLGLDVATEGFGtRVVNQTPIPGEKVKEGTKVVL 632
pbp2_mrdA TIGR03423
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
 13-549 6.64e-100

penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 274573 [Multi-domain]  Cd Length: 592  Bit Score: 318.70  E-value: 6.64e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223   13 ARFFYIQStgtVHNQDLDALAKQKHSKKGVLEANRGTIYDQNGHVLAQDANSYKMVAAlkgANSVENKEDTAKKIAGVLG 92
Cdd:TIGR03423  19 ARLFYLQV---IRGEEYATLSEDNRIRLVPIPPPRGLILDRNGVLLADNRPSFSLEIV---PEKVDDLDATLDRLAKLLD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223   93 KGEEDIlASLNKEGRSQVEFG--TLGKDLTKEKKEQIEA--LKLPGISFITENARVYPNGDFASYVIGH-AKPNEN---- 163
Cdd:TIGR03423  93 LDPEDI-ARFLKELKRSRRFEpiPLKSDLTEEEVARFAVnqYRLPGVEIEARLKRYYPYGELAAHVLGYvGEINEEdler 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  164 --------GTSVGQFGIEKSLDKYLSASNGEVAYTGDRKGVSLdgGKVNVKAPKNGDNAYLTIDQRVQSYLEDAMKAASK 235
Cdd:TIGR03423 172 lepanyagGDYIGKSGIEKYYEDELRGKPGYREVEVNARGRVI--RTLSRVPPVPGKDLVLTIDARLQQAAEKALGGRRG 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  236 qyepesliGIVA-DPKTGKILAMSTKPSYDPN--DRQIKY-------------FFNDAIANAFEPGSTMKIFTLAAAINE 299
Cdd:TIGR03423 250 --------AVVVmDPRTGEILAMVSTPSFDPNlfVDGISSkdykallndpdrpLLNRAIQGVYPPGSTFKPVVALAALEE 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  300 GVYKGQD-YYQSGTYQVGNRKIKDHNGGaGWGSITFDEGVERSSNVAFAILGdQKLGPERFRKYIHSFGLDEKTNIDLSG 378
Cdd:TIGR03423 322 GVITPETrIYCPGYFQLGGRRFRCWKRG-GHGRVDLRKAIEESCDVYFYQLA-LRLGIDKIAEYAKRFGFGQKTGIDLPG 399

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  379 EGSNTI--------LFDQQIQQ---VTTAFGQGS-TVTPIQLVQAATAIANDGKMMKPYAIDKIVDPiTDKVKLEHKPEE 446
Cdd:TIGR03423 400 EKSGLVpsrewkrkRFGQPWYPgdtLNVSIGQGYvLVTPLQLAVATAALANGGKLYKPHLVKSIEDP-DGGVVRRTEPEV 478

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  447 VGK-PVTKETAAQVRQLLESVVTSPKGTGTAYKID-GYSVGGKTGTAQIPDGKGG--YMTGRQNYIF----SFLGMAPMD 518
Cdd:TIGR03423 479 LRPlPISPENLDVVREGMRDVVNGPGGTARRARLGlPYKMAGKTGTAQVVSLKQGekYDAEQIPERLrdhaLFVAFAPYD 558

                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 924506223  519 DPQLVVYVAVkqpklkddENG------AQPLA-DIFKY 549
Cdd:TIGR03423 559 NPKIAVAVIV--------EHGgggssaAAPIArKIMDA 588
Transpeptidase pfam00905
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
 245-544 1.30e-78

Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.


Pssm-ID: 425939 [Multi-domain]  Cd Length: 296  Bit Score: 253.11  E-value: 1.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  245 IVADPKTGKILAMSTKPSYDPNDRqIKYFFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQDYYQSGTY-QVGNRKIKDH 323
Cdd:pfam00905   4 VVLDPKTGEVLAMVGKPSYDPNGF-IGPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWPGkQQGGKSIGDW 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  324 NGGaGWGSITFDEGVERSSNVAFAILGdQKLGPERFRKYIHSFGLDEKTNIDLSGEgSNTILFDQQIQQVTTAFGQGSTV 403
Cdd:pfam00905  83 NQD-QVGIGTLRQALEYSSNWYMQKLA-QKLGADKLRSYLKKFGYGNKTGIGLPGE-NAGYLTPYWLEGATASFGIGLTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  404 TPIQLVQAATAIANDGKMMKPYAIDKIVDPITDKVKlehkpeeVGKPVTKETAAQVRQLLESVVTSPKGTGTAyKIDGYS 483
Cdd:pfam00905 160 TPLQQAQAYAAIANGGKLVPPHLVKSIEDKVDPKVL-------NKLPISKSTAEKVKDMLRLVVNDGTGTGTA-AVPGYK 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 924506223  484 VGGKTGTAQI-PDGKGGYMTGrqNYIFSFLGMAPMDDPQLVVYVAVKQPKLKDDENGAQPLA 544
Cdd:pfam00905 232 VAGKTGTAQVaGPKGGGYYDG--AQIGWFVGYAPADNPKYAFAVLIDDPKRYYGGKVAAPIF 291
PRK15105 PRK15105
peptidoglycan synthase FtsI; Provisional
 101-563 4.28e-47

peptidoglycan synthase FtsI; Provisional


Pssm-ID: 185060 [Multi-domain]  Cd Length: 578  Bit Score: 175.78  E-value: 4.28e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 101 SLNKEGRsqveFGTLGKDLTKEKKEQIEALKLPGISFITENARVYPNGDFASYVIGHAkpneNGTSVGQFGIEKSLDKYL 180
Cdd:PRK15105 128 NANPKGR----FIYLARQVNPDMADYIKKLKLPGIHLREESRRYYPSGEVTAHLIGFT----NVDSQGIEGVEKSFDKWL 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 181 SASNGEVAYTGDRKG-VSLDGGKVNVKApknGDNAYLTIDQRVQSYLEDAMKAASKQYEPESLIGIVADPKTGKILAMST 259
Cdd:PRK15105 200 TGQPGERIVRKDRYGrVIEDISSTDSQA---AHNLALSIDERLQALVYRELNNAVAFNKAESGSAVLVDVNTGEVLAMAN 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 260 KPSYDPNDR---QIKYFFNDAIANAFEPGSTMKIFTLAAAINEGVYKGQDYYQSGTYQVGNRKIKDhngGAGWGSITFDE 336
Cdd:PRK15105 277 SPSYNPNNLsgtPKDAMRNRAITDVFEPGSTVKPMVVMTALQRGVVKENSVLNTVPYRINGHEIKD---VARYSELTLTG 353

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 337 GVERSSNVAFAILGDQKLGPERFRKYiHSFGLDEKTNIDLSGEGSNtiLFDQQ-----IQQVTTAFGQGSTVTPIQLVQA 411
Cdd:PRK15105 354 VLQKSSNVGVSKLALAMPSSALVDTY-SRFGLGKATNLGLVGERSG--LYPQKqrwsdIERATFSFGYGLMVTPLQLARV 430

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 412 ATAIANDGkMMKPYAIDKiVDPITDKVKLehKPEEVGKPVTketaaqvrQLLESVVTsPKGTGTAYKIDGYSVGGKTGTA 491
Cdd:PRK15105 431 YATIGSYG-IYRPLSITK-VDPPVPGERV--FPESIVRTVV--------HMMESVAL-PGGGGVKAAIKGYRIAIKTGTA 497

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 924506223 492 QI--PDGKggYMTgrqNYIFSFLGMAPMDDPQLVVYVAVKQPKLKDDENGAQPlADIFKYVTKNSLEYLKIKPN 563
Cdd:PRK15105 498 KKvgPDGR--YIN---KYIAYTAGVAPASQPRFALVVVINDPQAGKYYGGAVS-APVFGAIMGGVLRTMNIEPD 565
MrcB COG0744
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
 215-492 1.52e-46

Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440507 [Multi-domain]  Cd Length: 630  Bit Score: 175.11  E-value: 1.52e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 215 YLTIDQRVQSYLEDAMKAASKQYEPESL-IGIVA-DPKTGKILAMStkPSYDPNDRQikyfFNDAIANAFEPGSTMKIFT 292
Cdd:COG0744  298 YTTLDPKLQKAAEKAVKNVLPEGKPGGLqAALVVvDPKTGEVLAMV--GGRDYGKSQ----FNRATQAKRQPGSTFKPFV 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 293 LAAAINEG-----VYKGQDY-YQSGTYQVGNrkikdhNGGAGWGSITFDEGVERSSNVAFAILGdQKLGPERFRKYIHSF 366
Cdd:COG0744  372 YAAALEQGytpatTVDDEPVtFPGGGWSPKN------YDGRYRGPVTLREALANSLNTPAVRLA-QEVGLDKVVDTARRL 444

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 367 GLDEKTNIDLSgegsntilfdqqiqqvtTAFGQgSTVTPIQLVQAATAIANDGKMMKPYAIDKIVDPiTDKVKLEHKPEe 446
Cdd:COG0744  445 GITSPLDPNPS-----------------LALGT-SEVSPLEMASAYATFANGGVYVEPHAITKVTDA-DGKVLYEAKPK- 504

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 924506223 447 vGKPV-TKETAAQVRQLLESVVTSpkGTGTAYKIDGYSVGGKTGTAQ 492
Cdd:COG0744  505 -CEQViSPEVAYLMTDMLQDVVTS--GTGRAARLPGRPVAGKTGTTN 548
PRK10795 PRK10795
penicillin-binding protein 2; Provisional
 47-493 1.29e-25

penicillin-binding protein 2; Provisional


Pssm-ID: 236761 [Multi-domain]  Cd Length: 634  Bit Score: 112.17  E-value: 1.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  47 RGTIYDQNGHVLAQDANSYKMVAAlkgANSVENKEDTAKKIAGVLGKGEEDIlASLNKEGRSQVEFGT--LGKDLTKEKK 124
Cdd:PRK10795  69 RGIIYDRNGTPLALNRTIYQLEMM---PEKVDNLQQTLDALRSVVDLTDDDI-AAFRKERARSRRFTSipVKTNLTEVQV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 125 EQ--IEALKLPGISFITENARVYPNGDFASYVIGH-AKPNENGTS----------------VGQFGIEKSLDKYLSASNG 185
Cdd:PRK10795 145 ARfaVNQYRFPGVEVKGYQRRYYPYGSALTHVIGYvSKINDKDVErldkegklanyaathdIGKLGIERYYEDVLHGKTG 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 186 -EVAYTGDRkgvsldgGKV----NVKAPKNGDNAYLTIDQRVQSYLEDAM---KAASkqyepesligIVADPKTGKILAM 257
Cdd:PRK10795 225 yEEVEVNNR-------GRVirqlHEQPPQAGHDIYLTLDLKLQQYIETLLagsRAAV----------VVTDPRTGGILAL 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 258 STKPSYDPN-------DRQIKYFFND--------AIANAFEPGSTMKIFTLAAAINEGVY-KGQDYYQSGTYQV-GNRKI 320
Cdd:PRK10795 288 VSTPSYDPNlfvdgisSKDYSGLLNDpnrplinrATQGVYPPASTVKPYVAVSALSAGVItRNTSLFDPGWWQLpGSEKR 367

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 321 KDHNGGAGWGSITFDEGVERSSNVAFAILGdQKLGPERFRKYIHSFGLDEKTNIDLSGEGSNTILFDQ-----------Q 389
Cdd:PRK10795 368 YRDWKKWGHGRLNVTKSLEESADTFFYQVA-YDMGIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREwkqkrfkkpwyQ 446

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 390 IQQVTTAFGQGS-TVTPIQLVQAATAIANDGKMMKPYAIDKIVdpITDKVKLEHKPEE--VGKPVTK--ETAaqvRQLLE 464
Cdd:PRK10795 447 GDTIPVGIGQGYwTATPIQMSKALMTLINDGIVKVPHLLMSTA--EDGKQVPWVQPHEppVGDIHSGywEIA---KDGMY 521

                        490       500       510
                 ....*....|....*....|....*....|
gi 924506223 465 SVVTSPKGTGTAYKIDG-YSVGGKTGTAQI 493
Cdd:PRK10795 522 GVANRPNGTAHKYFASApYKIAAKSGTAQV 551
PBP_dimer pfam03717
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
 42-195 2.66e-23

Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.


Pssm-ID: 427460 [Multi-domain]  Cd Length: 178  Bit Score: 97.39  E-value: 2.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223   42 VLEANRGTIYDQNGHVLAQDANSYkMVAALKGANSVENKEDTAKKIAGVLGKGEEDILASLNK-----EGRSQVEFGTLG 116
Cdd:pfam03717   1 PIPAPRGEIYDRNGVVLATNKPVY-SLTITPSKLKKADALKTALKLAKLLSNYEDLDDEDLTErflkmNSYKSYYPVVIK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  117 KDLTKEKKEQIE--ALKLPGISFITENARVYPNGDFASYVIGH-------------AKPNENGTSVGQFGIEKSLDKYLS 181
Cdd:pfam03717  80 KNLSEEEVARIEenLLELPGVSIETDPVRYYPYGELAAHLLGYvgeiteeelekylDKGYSRGDLVGKSGLEKQYESVLR 159

                         170
                  ....*....|....
gi 924506223  182 ASNGEVAYTGDRKG 195
Cdd:pfam03717 160 GKDGVRQVEVDALG 173
MrcA COG5009
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
244-490 3.35e-22

Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 444033 [Multi-domain]  Cd Length: 785  Bit Score: 101.77  E-value: 3.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 244 GIVA-DPKTGKILAMSTkpSYDPNDRQikyfFNDAIANAFEPGSTMKIFTLAAAINEG------------VYkgQDYYQS 310
Cdd:COG5009  424 ALVAlDPHTGAVLALVG--GFDFEQSK----FNRATQAKRQPGSSFKPFVYAAALDNGytpatiindapiVF--DDGGGG 495

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 311 GTYQVGNrkikdhNGGAGWGSITFDEGVERSSN-VAFAILgdQKLGPERFRKYIHSFGLDEKTNIDLSgegsntilfdqq 389
Cdd:COG5009  496 GVWRPKN------YSGKFYGPTTLREALEKSRNlVTVRLL--QDVGIDYVIDYAERFGIYSKLPPNLS------------ 555

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 390 iqqvtTAFGQGStVTPIQLVQAATAIANDGKMMKPYAIDKIVDPiTDKVKLEHKPEEVGKP------------------- 450
Cdd:COG5009  556 -----LALGSGE-VTPLEMARAYAVFANGGYRVEPYLIDRIEDR-NGKVIYRADPARACEDcdaaewdgaeprlpdpaeq 628

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 924506223 451 -VTKETAAQVRQLLESVVTSpkGTGTAYKIDGYSVGGKTGT 490
Cdd:COG5009  629 vIDPRTAYQMTSMLRGVVQR--GTGRRARALGRDIAGKTGT 667
PASTA_Pbp2x-like_2 cd06575
PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the ...
 634-686 9.30e-16

PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are attached to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119326 [Multi-domain]  Cd Length: 54  Bit Score: 71.71  E-value: 9.30e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 924506223 634 TMPNIQGWALRDVMNLAKTLQLNLKPSGTGYVTEQSVAEGTLLQPGTELGVTL 686
Cdd:cd06575    1 TMPDLTGWSKRDALKLLELLGLKVKFSGSGYVVSQSIAPGTKVKKGTTITVTL 53
PASTA_Pbp2x-like_1 cd06576
PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the ...
 578-631 4.36e-11

PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by acylating the active site serine. PBPs catalyze key steps in the synthesis of the peptidoglycan, such as the interconnecting of glycan chains (polymers of N-glucosamine and N-acetylmuramic acid residues) and the cross-linking (transpeptidation) of short stem peptides, which are connected to glycan chains. Peptidoglycan is essential in cell division and protects bacteria from osmotic shock and lysis. PBP2x is one of the two monofunctional high molecular mass PBPs in Streptococcus pneumoniae and has been seen as the primary PBP target in beta-lactam-resistant strains. The PASTA domain is found at the C-termini of several PBPs and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119327 [Multi-domain]  Cd Length: 55  Bit Score: 58.29  E-value: 4.36e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 924506223 578 TVPDVNGKTMAEAGKAIDKAKLRPIVLGEG-KVQQQVPKATEQTLKGDRVFLVGD 631
Cdd:cd06576    1 KVPDVTGKSVEEAKKELKEAGLQPVVIGNGkKVKKQSPKPGEKVLEGSKVLLYTD 55
PASTA COG2815
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];
575-687 3.91e-10

PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442064 [Multi-domain]  Cd Length: 220  Bit Score: 60.27  E-value: 3.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 575 QQTTVPDVNGKTMAEAGKAIDKAKLRPIVLGE-------GKVQQQVPKATEQTLKGDRVFLV----GDKPTMPNIQGWAL 643
Cdd:COG2815   23 EEVTVPDVVGMTVDEAEAALEEAGLKVEVEEEysddvpaGTVISQDPAAGTKVKKGSTVTLTvskgPEKVTVPDLVGKSL 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 924506223 644 RDVMNLAKTLQLNLKPS--------GTGYVTEQSVAEGTLLQPGTElgVTLV 687
Cdd:COG2815  103 DEAEAALEAAGLKVGEVeeeysddvPKGTVISQSPAAGTEVPKGTT--VTLV 152
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
575-687 1.13e-09

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 61.35  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 575 QQTTVPDVNGKTMAEAGKAIDKAKLRPIVLGE--------GKVQQQVPKATEQTLKGDRVFLV----GDKPTMPNIQGWA 642
Cdd:NF033483 363 KEVTVPDVVGKTEAEAKEALEKAGLKVGKVEEeysddveeGKVISTDPEAGTRVKEGSTVTLVvskgPEKVKVPDLTGKS 442

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 924506223 643 LRDVMNLAKTLQLNLKPSGT--------GYVTEQSVAEGTLLQPGTElgVTLV 687
Cdd:NF033483 443 LDEAKKALEDAGLKVGTIEEeysddvpkGTVISQDPAAGTEVDKGTT--VTLT 493
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
575-687 3.53e-08

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 56.73  E-value: 3.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 575 QQTTVPDVNGKTMAEAGKAIDKAKLRPIVLGE--------GKVQQQVPKATEQTLKGDRVFLV---GDKP-TMPNIQGWA 642
Cdd:NF033483 431 EKVKVPDLTGKSLDEAKKALEDAGLKVGTIEEeysddvpkGTVISQDPAAGTEVDKGTTVTLTvskGPEPvTVPDVTGMS 510

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 924506223 643 LRDVMNLAKTLQLNLK----------PSGTgyVTEQSVAEGTLLQPGTElgVTLV 687
Cdd:NF033483 511 EEEAKSALESAGLKVGveeeevssdvPAGT--VISQSPAAGTEVAKGST--VTLT 561
PASTA COG2815
PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];
575-687 4.84e-08

PASTA domain, binds beta-lactams [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442064 [Multi-domain]  Cd Length: 220  Bit Score: 54.11  E-value: 4.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 575 QQTTVPDVNGKTMAEAGKAIDKAKLRPIV--------LGEGKVQQQVPKATEQTLKGDRVFLV---GDKP-TMPNIQGWA 642
Cdd:COG2815   90 EKVTVPDLVGKSLDEAEAALEAAGLKVGEveeeysddVPKGTVISQSPAAGTEVPKGTTVTLVvskGPEPvTVPDLVGLT 169

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 924506223 643 LRDVMNLAKTLQLNLK-----PSGT---GYVTEQSVAEGTLLQPGTElgVTLV 687
Cdd:COG2815  170 LEEAKAALEAAGLKVGvveeeYSDDvpaGTVISQSPAAGTKVEKGST--VTLT 220
PbpC COG4953
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
 216-490 2.18e-07

Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443980 [Multi-domain]  Cd Length: 773  Bit Score: 54.45  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 216 LTIDQRVQSYLEDAMKAAS---KQYEPESLIGIVADPKTGKILAM--STkpsyDPNDRQIkYFFNDAIANAFEPGSTMKI 290
Cdd:COG4953  276 TTLDAGLQRRLERLVRRYVrrlKQNGIHNAAVLVVDNRTGEVLAYvgSA----DFFDASR-QGQVDMVRALRSPGSTLKP 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 291 FTLAAAINEGV----------------YKGQDYyqSGTYQvgnrkikdhnggagwGSITFDEGVERSSNV-AFAILgdQK 353
Cdd:COG4953  351 FLYGLALDQGLihpetlladvptsfggYRPENF--DGTFQ---------------GPVSAREALARSLNIpAVRLL--EA 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 354 LGPERFRKYIHSFGLdekTNIDLSGE--GSNTILfdqqiqqvttafGqGSTVTPIQLVQAATAIANDGKMMKPYAidkiv 431
Cdd:COG4953  412 LGPARFYARLRRAGL---RLLLPPAEhyGLSLIL------------G-GAEVTLEELVGLYAALARGGEARPLRL----- 470

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 432 dpitdkvkLEHKPEEVGKPV-TKETAAQVRQLLESVVTSPKGTGTAYKIDGYSVGGKTGT 490
Cdd:COG4953  471 --------LAGEPASPGRRLlSPGAAWLVRDILSDVPRPDGAFGWRALDSPPPIAWKTGT 522
PASTA pfam03793
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ...
 577-629 2.82e-05

PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 461053 [Multi-domain]  Cd Length: 63  Bit Score: 42.22  E-value: 2.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  577 TTVPDVNGKTMAEAGKAIDKAKLR-------PIVLGEGKVQQQVPKATEQTLKGDRVFLV 629
Cdd:pfam03793   1 VTVPDVVGLSLEEAKKLLEALGLKvgtveeySDDVGEGTVISQSPPAGTKVKKGSKVTLT 60
PASTA pfam03793
PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and ...
 634-686 6.83e-05

PASTA domain; This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 461053 [Multi-domain]  Cd Length: 63  Bit Score: 41.07  E-value: 6.83e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223  634 TMPNIQGWALRDVMNLAKTLQLNLK-------PSGTGYVTEQSVAEGTLLQPGTELGVTL 686
Cdd:pfam03793   2 TVPDVVGLSLEEAKKLLEALGLKVGtveeysdDVGEGTVISQSPPAGTKVKKGSKVTLTV 61
PASTA smart00740
PASTA domain;
573-629 4.10e-04

PASTA domain;


Pssm-ID: 197851 [Multi-domain]  Cd Length: 67  Bit Score: 39.21  E-value: 4.10e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 924506223   573 KEQQTTVPDVNGKTMAEAGKAIDKAKLRPIVL-------GEGKVQQQVPKATEQTLKGDRVFLV 629
Cdd:smart00740   1 GPEKVEVPDVIGKSKEEAKKLLKALGLKVEVVeeyssdgEEGTVISQSPAAGTTVKPGSKVTLT 64
PASTA_pknB cd06577
PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a ...
 578-629 5.18e-03

PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis. PknB is a receptor-like transmembrane protein with an extracellular signal sensor domain (containing multiple PASTA domains) and an intracellular, eukaryotic serine/threonine kinase-like domain. The PASTA domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.


Pssm-ID: 119328 [Multi-domain]  Cd Length: 62  Bit Score: 35.97  E-value: 5.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 924506223 578 TVPDVNGKTMAEAGKAIDKAKLRPIVLGE--------GKVQQQVPKATEQTLKGDRVFLV 629
Cdd:cd06577    1 TVPDVVGMTLDEAKAALEAAGLKVGVVTEeysddvpkGTVISQSPAAGTKVKKGSTVTLT 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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