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penicillin-binding protein 2 [Bacillus sp. FJAT-18017]
Protein Classification
peptidoglycan D,D-transpeptidase FtsI family protein ( domain architecture ID 11433609 )
peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
3-578
1.42e-98
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 310.99
E-value: 1.42e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 3 KK R AARMLYFYMVI FL I L A GRL VQI Q LW E PESFS shhinll E ESVRQ R SQELV I DDG RG R I L DR K G E -- SMTHEDL S VLI 80
Cdd:COG0768 11 RR R LLLLFLLVLLL FL L L V GRL FYL Q VV E GDEYA ------- E LAEEN R IRTVP I PAP RG L I Y DR N G N vl ATNVPVY S LYA 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 81 LFPFL K NASWPV EK V A NAV G VEEN E ILQAV K QAK apfal GE P KP L -- S L TSSQVQL I NS LK I PGV F a VE KKFE --- KQDA 155
Cdd:COG0768 84 DPEEV K DPEETA EK L A KLL G LDPE E LRKKL K KKS ----- RF P VY L kr N L SPEEAAR I RA LK L PGV Y - VE AEYK ryy PYGE 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 156 V A KQLI G VL GE NE telskrypdrslp LRTQ IG I SGLE VSFDEI L v AERKSQLVYH VD GS G SPLFG tkvk YTGITN P FYPA 235
Cdd:COG0768 158 L A AHVL G YV GE IN ------------- GGDG IG K SGLE KAYEDL L - RGTPGKRRVE VD AR G RVIRD ---- LGEEKP P VPGK 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 236 SIKT TID L D I QK Q AE QL ---- V DKHGI K K G GLILL D IS T NS ILA TV S R P NVNDKDPFK G NG -- MV N LMLKEQI - M GS V FK 308
Cdd:COG0768 220 DLVL TID S D L QK I AE EA lkka V EEYKA K S G AVVVM D PK T GE ILA MA S Y P SFDPNLFVG G PD ep LR N RAVQGTY e P GS T FK 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 309 TAV AAAA IDY G LDGEERLY DC SR -- TID GR P --- DQVYQ HG L L GFSDSF A M S C N NT F AS LA kel MEIDPNI L EE Y AE K LS 383
Cdd:COG0768 300 PFT AAAA LEE G VITPDTTF DC PG yy RVG GR T ird WDRGG HG T L TLTEAL A K S S N VG F YK LA --- LRLGIDK L YD Y LK K FG 376
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 384 L tggvgwr G HVFQ I anfs Q LP D E EK G RVF i S DEERNDRNYVAL S g IGQ k EVRA TPL AV A NMM A T IA R GG EKEMVRA V S EI 463
Cdd:COG0768 377 L ------- G QKTG I ---- D LP G E AS G LLP - S PKRWYPGETATM S - IGQ - GLSV TPL QL A QAY A A IA N GG VLVKPHL V K EI 442
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 464 TYKN G A V MYTF PE nk LNGEQL S SG TA KELGQLLRE VV VNEN GT G R WFSELP Y E VAGK S GTA ETGRFK NG KQLHNK --- W F 540
Cdd:COG0768 443 VDPD G E V VKEE PE -- VLRRVI S PE TA ETVREGMEG VV NEPG GT A R RAAIPG Y R VAGK T GTA QVVDIG NG GYYKGR hia S F 520
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 926260680 541 A G YF P YR NPR F A - L V T V NLDVY G HE GG VN -- P L F ADMVTFL 578
Cdd:COG0768 521 V G FA P AD NPR Y A v A V V V ENPGG G AY GG TV aa P V F REIMEAY 561
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
3-578
1.42e-98
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 310.99
E-value: 1.42e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 3 KK R AARMLYFYMVI FL I L A GRL VQI Q LW E PESFS shhinll E ESVRQ R SQELV I DDG RG R I L DR K G E -- SMTHEDL S VLI 80
Cdd:COG0768 11 RR R LLLLFLLVLLL FL L L V GRL FYL Q VV E GDEYA ------- E LAEEN R IRTVP I PAP RG L I Y DR N G N vl ATNVPVY S LYA 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 81 LFPFL K NASWPV EK V A NAV G VEEN E ILQAV K QAK apfal GE P KP L -- S L TSSQVQL I NS LK I PGV F a VE KKFE --- KQDA 155
Cdd:COG0768 84 DPEEV K DPEETA EK L A KLL G LDPE E LRKKL K KKS ----- RF P VY L kr N L SPEEAAR I RA LK L PGV Y - VE AEYK ryy PYGE 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 156 V A KQLI G VL GE NE telskrypdrslp LRTQ IG I SGLE VSFDEI L v AERKSQLVYH VD GS G SPLFG tkvk YTGITN P FYPA 235
Cdd:COG0768 158 L A AHVL G YV GE IN ------------- GGDG IG K SGLE KAYEDL L - RGTPGKRRVE VD AR G RVIRD ---- LGEEKP P VPGK 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 236 SIKT TID L D I QK Q AE QL ---- V DKHGI K K G GLILL D IS T NS ILA TV S R P NVNDKDPFK G NG -- MV N LMLKEQI - M GS V FK 308
Cdd:COG0768 220 DLVL TID S D L QK I AE EA lkka V EEYKA K S G AVVVM D PK T GE ILA MA S Y P SFDPNLFVG G PD ep LR N RAVQGTY e P GS T FK 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 309 TAV AAAA IDY G LDGEERLY DC SR -- TID GR P --- DQVYQ HG L L GFSDSF A M S C N NT F AS LA kel MEIDPNI L EE Y AE K LS 383
Cdd:COG0768 300 PFT AAAA LEE G VITPDTTF DC PG yy RVG GR T ird WDRGG HG T L TLTEAL A K S S N VG F YK LA --- LRLGIDK L YD Y LK K FG 376
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 384 L tggvgwr G HVFQ I anfs Q LP D E EK G RVF i S DEERNDRNYVAL S g IGQ k EVRA TPL AV A NMM A T IA R GG EKEMVRA V S EI 463
Cdd:COG0768 377 L ------- G QKTG I ---- D LP G E AS G LLP - S PKRWYPGETATM S - IGQ - GLSV TPL QL A QAY A A IA N GG VLVKPHL V K EI 442
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 464 TYKN G A V MYTF PE nk LNGEQL S SG TA KELGQLLRE VV VNEN GT G R WFSELP Y E VAGK S GTA ETGRFK NG KQLHNK --- W F 540
Cdd:COG0768 443 VDPD G E V VKEE PE -- VLRRVI S PE TA ETVREGMEG VV NEPG GT A R RAAIPG Y R VAGK T GTA QVVDIG NG GYYKGR hia S F 520
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 926260680 541 A G YF P YR NPR F A - L V T V NLDVY G HE GG VN -- P L F ADMVTFL 578
Cdd:COG0768 521 V G FA P AD NPR Y A v A V V V ENPGG G AY GG TV aa P V F REIMEAY 561
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
4-556
4.07e-54
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 193.51
E-value: 4.07e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 4 K RA ARMLYFYMVI F LI LA G RL VQI Q LWEP E SFS shhinll EE S VRQ R SQELV I DDG RG R ILDR K G ESMTHEDL S - V L ILF 82
Cdd:TIGR03423 1 R RA LVLGGLVLAL F GV LA A RL FYL Q VIRG E EYA ------- TL S EDN R IRLVP I PPP RG L ILDR N G VLLADNRP S f S L EIV 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 83 P - FLKNASWPVEKV A NAVGVEENE I LQAV K QA K A -- P F alg EP K PL -- S LT SSQ V QLI -- N SLKI PGV F -- A VE K KFEKQ 153
Cdd:TIGR03423 74 P e KVDDLDATLDRL A KLLDLDPED I ARFL K EL K R sr R F --- EP I PL ks D LT EEE V ARF av N QYRL PGV E ie A RL K RYYPY 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 154 DAV A KQLI G VL GE - NE TE L SKRY P d RSLPLRTQ IG I SG L E VSFDEI L VAERKSQL V y H V DGS G SP lfgtk VKYTGITN P F 232
Cdd:TIGR03423 151 GEL A AHVL G YV GE i NE ED L ERLE P - ANYAGGDY IG K SG I E KYYEDE L RGKPGYRE V - E V NAR G RV ----- IRTLSRVP P V 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 233 YPASIKT TID LDI Q KQ AE QLVDK hgi KK G GLILL D IS T NS ILA T VS R P ---- N V -------------- ND K D pfkg NGMV 294
Cdd:TIGR03423 224 PGKDLVL TID ARL Q QA AE KALGG --- RR G AVVVM D PR T GE ILA M VS T P sfdp N L fvdgisskdykall ND P D ---- RPLL 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 295 N LMLKEQIM - GS V FK TA VA A AA IDY G LDGE E RLYD C -- SRTID GR P --- DQVYQ HG LLGFSDSFAM SC NNT F AS LA k ELM 368
Cdd:TIGR03423 297 N RAIQGVYP p GS T FK PV VA L AA LEE G VITP E TRIY C pg YFQLG GR R frc WKRGG HG RVDLRKAIEE SC DVY F YQ LA - LRL 375
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 369 E ID P ni LE EYA EKLSL tggvgwr G HVFQ I anfs Q LP D E EK G rv FISDE E RNDRNYV ------- A L S - G IGQ KE V RA TPL A 440
Cdd:TIGR03423 376 G ID K -- IA EYA KRFGF ------- G QKTG I ---- D LP G E KS G -- LVPSR E WKRKRFG qpwypgd T L N v S IGQ GY V LV TPL Q 440
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 441 V A NMM A TI A R GG EKEMVRA V SE I TYKN G A V MYTFPENK L NGEQL S SGTAKELGQLL R E VV VNEN GT G R W - FSE LPY EV AG 519
Cdd:TIGR03423 441 L A VAT A AL A N GG KLYKPHL V KS I EDPD G G V VRRTEPEV L RPLPI S PENLDVVREGM R D VV NGPG GT A R R a RLG LPY KM AG 520
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 926260680 520 K S GTA ETGRF K ----- NGK Q L ----- HNKW F AGYF PY R NP RF A LVTV 556
Cdd:TIGR03423 521 K T GTA QVVSL K qgeky DAE Q I perlr DHAL F VAFA PY D NP KI A VAVI 567
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
261-573
8.63e-33
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 127.53
E-value: 8.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 261 G GLIL LD IS T NSI LA T V SR P nvn DK DP FKGN G - MV N LMLKEQI - M GS V FK TAV A A AA I D Y G - L DGE E RLY D CSRTI dg RP 337
Cdd:pfam00905 1 G SAVV LD PK T GEV LA M V GK P --- SY DP NGFI G p LR N RAVTSRY e P GS T FK PFT A L AA L D N G v L KPD E TIF D WPGKQ -- QG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 338 DQVY ------ Q H G LLGFSDSFAM S C N NTFAS LA KE L mei DPNI L EE Y AE K L sltg G V G wrghvfq IANFSQ LP D E EK G rv 411
Cdd:pfam00905 76 GKSI gdwnqd Q V G IGTLRQALEY S S N WYMQK LA QK L --- GADK L RS Y LK K F ---- G Y G ------- NKTGIG LP G E NA G -- 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 412 f ISDEERNDRNYVA l S GIG qke VRA TPL AV A NMM A T IA R GG EKEMVRA V SE I TY K ngavmyt FPENK LN GEQL S SG TA KE 491
Cdd:pfam00905 140 - YLTPYWLEGATAS - F GIG --- LTI TPL QQ A QAY A A IA N GG KLVPPHL V KS I ED K ------- VDPKV LN KLPI S KS TA EK 207
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 492 LGQL LR E VV VNEN GTG RWFSE l P Y E VAGK S GTA ETGRF K N G K --- QLHNK WF A GY F P YR NP RF A LVTVNL D VYGHE GG -- 566
Cdd:pfam00905 208 VKDM LR L VV NDGT GTG TAAVP - G Y K VAGK T GTA QVAGP K G G G yyd GAQIG WF V GY A P AD NP KY A FAVLID D PKRYY GG kv 286
....*..
gi 926260680 567 VN P L F A D 573
Cdd:pfam00905 287 AA P I F K D 293
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
237-569
6.65e-07
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 52.46
E-value: 6.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 237 I KT T I DL DI Q KQA E Q L VDK hgi KKGGLILL D IS T NS ILA T VS R P NV n D KDP F KG ------- N G MV N ---- LMLKEQIM G - 304
Cdd:PRK10795 251 I YL T L DL KL Q QYI E T L LAG --- SRAAVVVT D PR T GG ILA L VS T P SY - D PNL F VD gisskdy S G LL N dpnr PLINRATQ G v 326
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 305 ---- S VF K TA VA AA A IDY G --------------- L D G E E RL Y dcsrtidg R PDQVYQ HG L L GFSD S FAM S CNNT F ASL A K 365
Cdd:PRK10795 327 yppa S TV K PY VA VS A LSA G vitrntslfdpgwwq L P G S E KR Y -------- R DWKKWG HG R L NVTK S LEE S ADTF F YQV A Y 398
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 366 E l M E ID pn I L E E YAE K L sltggv G W r GH VFQ I anfs Q L PD E EK G rv FISDE E RNDRNY -------- VALS GIGQ KEVR AT 437
Cdd:PRK10795 399 D - M G ID -- R L S E WMG K F ------ G Y - GH YTG I ---- D L AE E RS G -- NMPTR E WKQKRF kkpwyqgd TIPV GIGQ GYWT AT 462
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 438 P LAVANMMA T IARG G EKEMVRAVSEITYKNGA V MYTF P ENKLN G E q LS SG TAKELGQLLRE V VVNE NGT GR - W F SEL PY E 516
Cdd:PRK10795 463 P IQMSKALM T LIND G IVKVPHLLMSTAEDGKQ V PWVQ P HEPPV G D - IH SG YWEIAKDGMYG V ANRP NGT AH k Y F ASA PY K 541
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 926260680 517 V A G KSGTA ETGRF K ----- N GKQL ----- HN K WFAGYF PY R NP RF A l V TVN L D vygh E GG VN P 569
Cdd:PRK10795 542 I A A KSGTA QVFGL K anety N AHKI aerlr DH K LMTAFA PY N NP QV A - V AII L E ---- N GG AG P 599
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
3-578
1.42e-98
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 310.99
E-value: 1.42e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 3 KK R AARMLYFYMVI FL I L A GRL VQI Q LW E PESFS shhinll E ESVRQ R SQELV I DDG RG R I L DR K G E -- SMTHEDL S VLI 80
Cdd:COG0768 11 RR R LLLLFLLVLLL FL L L V GRL FYL Q VV E GDEYA ------- E LAEEN R IRTVP I PAP RG L I Y DR N G N vl ATNVPVY S LYA 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 81 LFPFL K NASWPV EK V A NAV G VEEN E ILQAV K QAK apfal GE P KP L -- S L TSSQVQL I NS LK I PGV F a VE KKFE --- KQDA 155
Cdd:COG0768 84 DPEEV K DPEETA EK L A KLL G LDPE E LRKKL K KKS ----- RF P VY L kr N L SPEEAAR I RA LK L PGV Y - VE AEYK ryy PYGE 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 156 V A KQLI G VL GE NE telskrypdrslp LRTQ IG I SGLE VSFDEI L v AERKSQLVYH VD GS G SPLFG tkvk YTGITN P FYPA 235
Cdd:COG0768 158 L A AHVL G YV GE IN ------------- GGDG IG K SGLE KAYEDL L - RGTPGKRRVE VD AR G RVIRD ---- LGEEKP P VPGK 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 236 SIKT TID L D I QK Q AE QL ---- V DKHGI K K G GLILL D IS T NS ILA TV S R P NVNDKDPFK G NG -- MV N LMLKEQI - M GS V FK 308
Cdd:COG0768 220 DLVL TID S D L QK I AE EA lkka V EEYKA K S G AVVVM D PK T GE ILA MA S Y P SFDPNLFVG G PD ep LR N RAVQGTY e P GS T FK 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 309 TAV AAAA IDY G LDGEERLY DC SR -- TID GR P --- DQVYQ HG L L GFSDSF A M S C N NT F AS LA kel MEIDPNI L EE Y AE K LS 383
Cdd:COG0768 300 PFT AAAA LEE G VITPDTTF DC PG yy RVG GR T ird WDRGG HG T L TLTEAL A K S S N VG F YK LA --- LRLGIDK L YD Y LK K FG 376
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 384 L tggvgwr G HVFQ I anfs Q LP D E EK G RVF i S DEERNDRNYVAL S g IGQ k EVRA TPL AV A NMM A T IA R GG EKEMVRA V S EI 463
Cdd:COG0768 377 L ------- G QKTG I ---- D LP G E AS G LLP - S PKRWYPGETATM S - IGQ - GLSV TPL QL A QAY A A IA N GG VLVKPHL V K EI 442
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 464 TYKN G A V MYTF PE nk LNGEQL S SG TA KELGQLLRE VV VNEN GT G R WFSELP Y E VAGK S GTA ETGRFK NG KQLHNK --- W F 540
Cdd:COG0768 443 VDPD G E V VKEE PE -- VLRRVI S PE TA ETVREGMEG VV NEPG GT A R RAAIPG Y R VAGK T GTA QVVDIG NG GYYKGR hia S F 520
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 926260680 541 A G YF P YR NPR F A - L V T V NLDVY G HE GG VN -- P L F ADMVTFL 578
Cdd:COG0768 521 V G FA P AD NPR Y A v A V V V ENPGG G AY GG TV aa P V F REIMEAY 561
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
4-556
4.07e-54
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 193.51
E-value: 4.07e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 4 K RA ARMLYFYMVI F LI LA G RL VQI Q LWEP E SFS shhinll EE S VRQ R SQELV I DDG RG R ILDR K G ESMTHEDL S - V L ILF 82
Cdd:TIGR03423 1 R RA LVLGGLVLAL F GV LA A RL FYL Q VIRG E EYA ------- TL S EDN R IRLVP I PPP RG L ILDR N G VLLADNRP S f S L EIV 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 83 P - FLKNASWPVEKV A NAVGVEENE I LQAV K QA K A -- P F alg EP K PL -- S LT SSQ V QLI -- N SLKI PGV F -- A VE K KFEKQ 153
Cdd:TIGR03423 74 P e KVDDLDATLDRL A KLLDLDPED I ARFL K EL K R sr R F --- EP I PL ks D LT EEE V ARF av N QYRL PGV E ie A RL K RYYPY 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 154 DAV A KQLI G VL GE - NE TE L SKRY P d RSLPLRTQ IG I SG L E VSFDEI L VAERKSQL V y H V DGS G SP lfgtk VKYTGITN P F 232
Cdd:TIGR03423 151 GEL A AHVL G YV GE i NE ED L ERLE P - ANYAGGDY IG K SG I E KYYEDE L RGKPGYRE V - E V NAR G RV ----- IRTLSRVP P V 223
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 233 YPASIKT TID LDI Q KQ AE QLVDK hgi KK G GLILL D IS T NS ILA T VS R P ---- N V -------------- ND K D pfkg NGMV 294
Cdd:TIGR03423 224 PGKDLVL TID ARL Q QA AE KALGG --- RR G AVVVM D PR T GE ILA M VS T P sfdp N L fvdgisskdykall ND P D ---- RPLL 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 295 N LMLKEQIM - GS V FK TA VA A AA IDY G LDGE E RLYD C -- SRTID GR P --- DQVYQ HG LLGFSDSFAM SC NNT F AS LA k ELM 368
Cdd:TIGR03423 297 N RAIQGVYP p GS T FK PV VA L AA LEE G VITP E TRIY C pg YFQLG GR R frc WKRGG HG RVDLRKAIEE SC DVY F YQ LA - LRL 375
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 369 E ID P ni LE EYA EKLSL tggvgwr G HVFQ I anfs Q LP D E EK G rv FISDE E RNDRNYV ------- A L S - G IGQ KE V RA TPL A 440
Cdd:TIGR03423 376 G ID K -- IA EYA KRFGF ------- G QKTG I ---- D LP G E KS G -- LVPSR E WKRKRFG qpwypgd T L N v S IGQ GY V LV TPL Q 440
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 441 V A NMM A TI A R GG EKEMVRA V SE I TYKN G A V MYTFPENK L NGEQL S SGTAKELGQLL R E VV VNEN GT G R W - FSE LPY EV AG 519
Cdd:TIGR03423 441 L A VAT A AL A N GG KLYKPHL V KS I EDPD G G V VRRTEPEV L RPLPI S PENLDVVREGM R D VV NGPG GT A R R a RLG LPY KM AG 520
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 926260680 520 K S GTA ETGRF K ----- NGK Q L ----- HNKW F AGYF PY R NP RF A LVTV 556
Cdd:TIGR03423 521 K T GTA QVVSL K qgeky DAE Q I perlr DHAL F VAFA PY D NP KI A VAVI 567
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
261-573
8.63e-33
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 127.53
E-value: 8.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 261 G GLIL LD IS T NSI LA T V SR P nvn DK DP FKGN G - MV N LMLKEQI - M GS V FK TAV A A AA I D Y G - L DGE E RLY D CSRTI dg RP 337
Cdd:pfam00905 1 G SAVV LD PK T GEV LA M V GK P --- SY DP NGFI G p LR N RAVTSRY e P GS T FK PFT A L AA L D N G v L KPD E TIF D WPGKQ -- QG 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 338 DQVY ------ Q H G LLGFSDSFAM S C N NTFAS LA KE L mei DPNI L EE Y AE K L sltg G V G wrghvfq IANFSQ LP D E EK G rv 411
Cdd:pfam00905 76 GKSI gdwnqd Q V G IGTLRQALEY S S N WYMQK LA QK L --- GADK L RS Y LK K F ---- G Y G ------- NKTGIG LP G E NA G -- 139
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 412 f ISDEERNDRNYVA l S GIG qke VRA TPL AV A NMM A T IA R GG EKEMVRA V SE I TY K ngavmyt FPENK LN GEQL S SG TA KE 491
Cdd:pfam00905 140 - YLTPYWLEGATAS - F GIG --- LTI TPL QQ A QAY A A IA N GG KLVPPHL V KS I ED K ------- VDPKV LN KLPI S KS TA EK 207
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 492 LGQL LR E VV VNEN GTG RWFSE l P Y E VAGK S GTA ETGRF K N G K --- QLHNK WF A GY F P YR NP RF A LVTVNL D VYGHE GG -- 566
Cdd:pfam00905 208 VKDM LR L VV NDGT GTG TAAVP - G Y K VAGK T GTA QVAGP K G G G yyd GAQIG WF V GY A P AD NP KY A FAVLID D PKRYY GG kv 286
....*..
gi 926260680 567 VN P L F A D 573
Cdd:pfam00905 287 AA P I F K D 293
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
237-546
1.42e-28
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 120.41
E-value: 1.42e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 237 I K TT I D LDI QK Q AE QL V DKHGIKK ------ GG L ILL D IS T NSI LA T V S rpnvn DK D PF K GNGMVNLML K E Q I m GS V FK TA 310
Cdd:COG0744 297 I Y TT L D PKL QK A AE KA V KNVLPEG kpgglq AA L VVV D PK T GEV LA M V G ----- GR D YG K SQFNRATQA K R Q P - GS T FK PF 370
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 311 V A AAA IDY G LDGEERLY D CSR T ID G RPDQV ----- YQH G LLGFSDSF A M S C N NTFAS LA kel M E IDPNILEEY A EK L slt 385
Cdd:COG0744 371 V Y AAA LEQ G YTPATTVD D EPV T FP G GGWSP knydg RYR G PVTLREAL A N S L N TPAVR LA --- Q E VGLDKVVDT A RR L --- 444
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 386 g G V gwrghvfqianfsqlpdeekgrvfisde ERNDRNYVA L S g I G QK EV ra T PL AV A NMM AT I A R GG EKEMVR A VSEI T Y 465
Cdd:COG0744 445 - G I ---------------------------- TSPLDPNPS L A - L G TS EV -- S PL EM A SAY AT F A N GG VYVEPH A ITKV T D 492
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 466 KN G A V M Y tfp E N K LNG EQ - L S SGT A KELGQL L RE VV vn EN GTGR WFSELPYE VAGK S GT AETG R fkngkqlh NK WF A GY F 544
Cdd:COG0744 493 AD G K V L Y --- E A K PKC EQ v I S PEV A YLMTDM L QD VV -- TS GTGR AARLPGRP VAGK T GT TNDN R -------- DA WF V GY T 559
..
gi 926260680 545 P Y 546
Cdd:COG0744 560 P Q 561
PBP_dimer
pfam03717 Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of ...
60-218
1.66e-07
Penicillin-binding Protein dimerization domain; This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Pssm-ID: 427460 [Multi-domain]
Cd Length: 178
Bit Score: 51.55
E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 60 RG R I L DR K G ESMT -- HEDL S VL I LFPF LK N A SW -- PVE K V A NAVGVE E N --- E I L QAVKQAKAPFALGE P KPL -- S L TSS 130
Cdd:pfam03717 6 RG E I Y DR N G VVLA tn KPVY S LT I TPSK LK K A DA lk TAL K L A KLLSNY E D ldd E D L TERFLKMNSYKSYY P VVI kk N L SEE 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 131 Q V QL I -- N S L KI PGV FAVE -- KKFEKQDAV A KQ L I G VL GE NET E LSKR Y P D RSLPLRTQI G I SGLE VSFDEI L VA e RKSQ 206
Cdd:pfam03717 86 E V AR I ee N L L EL PGV SIET dp VRYYPYGEL A AH L L G YV GE ITE E ELEK Y L D KGYSRGDLV G K SGLE KQYESV L RG - KDGV 164
170
....*....|..
gi 926260680 207 LVYH VD GS G SPL 218
Cdd:pfam03717 165 RQVE VD AL G RVI 176
MrcA
COG5009 Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
437-556
1.81e-07
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain]
Cd Length: 785
Bit Score: 54.40
E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 437 TPL AV A NMM A TI A R GG EKEMVRAVSE I TYK NG A V M Y TF ------------------ P ENKLNG EQ - LSSG TA KELGQL LR 497
Cdd:COG5009 564 TPL EM A RAY A VF A N GG YRVEPYLIDR I EDR NG K V I Y RA dparacedcdaaewdgae P RLPDPA EQ v IDPR TA YQMTSM LR 643
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 926260680 498 E VV vn EN GTGR WFSE L PYEV AGK S GT ae T GRF K NG kqlhnk WF A G YF P Y rnprfa LV TV 556
Cdd:COG5009 644 G VV -- QR GTGR RARA L GRDI AGK T GT -- T NDS K DA ------ WF V G FT P D ------ LV AG 686
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
237-569
6.65e-07
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 52.46
E-value: 6.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 237 I KT T I DL DI Q KQA E Q L VDK hgi KKGGLILL D IS T NS ILA T VS R P NV n D KDP F KG ------- N G MV N ---- LMLKEQIM G - 304
Cdd:PRK10795 251 I YL T L DL KL Q QYI E T L LAG --- SRAAVVVT D PR T GG ILA L VS T P SY - D PNL F VD gisskdy S G LL N dpnr PLINRATQ G v 326
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 305 ---- S VF K TA VA AA A IDY G --------------- L D G E E RL Y dcsrtidg R PDQVYQ HG L L GFSD S FAM S CNNT F ASL A K 365
Cdd:PRK10795 327 yppa S TV K PY VA VS A LSA G vitrntslfdpgwwq L P G S E KR Y -------- R DWKKWG HG R L NVTK S LEE S ADTF F YQV A Y 398
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 366 E l M E ID pn I L E E YAE K L sltggv G W r GH VFQ I anfs Q L PD E EK G rv FISDE E RNDRNY -------- VALS GIGQ KEVR AT 437
Cdd:PRK10795 399 D - M G ID -- R L S E WMG K F ------ G Y - GH YTG I ---- D L AE E RS G -- NMPTR E WKQKRF kkpwyqgd TIPV GIGQ GYWT AT 462
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 438 P LAVANMMA T IARG G EKEMVRAVSEITYKNGA V MYTF P ENKLN G E q LS SG TAKELGQLLRE V VVNE NGT GR - W F SEL PY E 516
Cdd:PRK10795 463 P IQMSKALM T LIND G IVKVPHLLMSTAEDGKQ V PWVQ P HEPPV G D - IH SG YWEIAKDGMYG V ANRP NGT AH k Y F ASA PY K 541
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 926260680 517 V A G KSGTA ETGRF K ----- N GKQL ----- HN K WFAGYF PY R NP RF A l V TVN L D vygh E GG VN P 569
Cdd:PRK10795 542 I A A KSGTA QVFGL K anety N AHKI aerlr DH K LMTAFA PY N NP QV A - V AII L E ---- N GG AG P 599
mrcB
PRK09506 bifunctional glycosyl transferase/transpeptidase; Reviewed
437-542
1.71e-04
bifunctional glycosyl transferase/transpeptidase; Reviewed
Pssm-ID: 236544 [Multi-domain]
Cd Length: 830
Bit Score: 44.76
E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 437 TP LA VA NMMA TIA R GG EKEMVR A VSEITYKN G A V M Y - T FP E nkln G E QLSSGT A KE L GQLLREV VV n EN GTGR WFS - EL P 514
Cdd:PRK09506 613 TP IE VA QAFQ TIA S GG NRAPLS A LRSVIAED G K V L Y q S FP Q ---- A E RAVPAQ A AY L TLYTMQQ VV - QR GTGR QLG a KY P 687
90 100
....*....|....*....|....*....
gi 926260680 515 - YEV AGK S GT A etgrfkng KQ L HNK WFAG 542
Cdd:PRK09506 688 n LHL AGK T GT T -------- ND L VDS WFAG 708
PRK14850
PRK14850 penicillin-binding protein 1b; Provisional
437-542
3.36e-03
penicillin-binding protein 1b; Provisional
Pssm-ID: 237835 [Multi-domain]
Cd Length: 764
Bit Score: 40.60
E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 437 TP LA VA NMMAT I AR GG E K EMVRAVSE I TYKNGA V M Y - T FP EN K ----------- L NGE Q -- LS SGTAK E LG QL lrevvvn 502
Cdd:PRK14850 559 TP ME VA QVFQI I GS GG Y K SSLSSIRS I ISDDNK V L Y q N FP QS K hvessqasylt L YAM Q qv VK SGTAK S LG TI ------- 631
90 100 110 120
....*....|....*....|....*....|....*....|
gi 926260680 503 engtgrw F S E L py EV AGK S GT A etgrfkng KQ L HNK WF A G 542
Cdd:PRK14850 632 ------- F K E F -- SL AGK T GT T -------- NN L VDS WF V G 654
PbpC
COG4953 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ...
234-320
3.50e-03
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443980 [Multi-domain]
Cd Length: 773
Bit Score: 40.20
E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926260680 234 PAS I K TT I D LDI Q KQA E Q LV DKH ------- GI KKGGLILL D IS T NSI LA T V SRPNVN D KDPFKGNG MV nlmlke QIM --- 303
Cdd:COG4953 271 GTR I R TT L D AGL Q RRL E R LV RRY vrrlkqn GI HNAAVLVV D NR T GEV LA Y V GSADFF D ASRQGQVD MV ------ RAL rsp 344
90
....*....|....*..
gi 926260680 304 GS VF K TAVAAA A I D Y GL 320
Cdd:COG4953 345 GS TL K PFLYGL A L D Q GL 361
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
