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Conserved domains on  [gi|926315076|ref|WP_053650243|]
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MULTISPECIES: FadR/GntR family transcriptional regulator [unclassified Streptomyces]

Protein Classification

FadR/GntR family transcriptional regulator( domain architecture ID 11450686)

helix-turn-helix transcriptional regulator belonging to the GntR family, which contains FadR, HutC, MocR, YtrA, AraR, PlmA, and many other subfamilies

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-204 1.36e-27

DNA-binding transcriptional regulator, FadR family [Transcription];


:

Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 105.40  E-value: 1.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076   4 QPIRREAVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRRTAGL 83
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  84 ELAVGIARAAtgpalPELARDALEMRACIGADAARLCAARCSRETAAAVVEAAGAYAQAGPDLAALGEADIAWWRLIVEG 163
Cdd:COG2186   81 DPLALLLALD-----DASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEA 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 926315076 164 SGNLAYLLSFNSLVGGTLTVGDVPVDLRTAELLDVDAHVRL 204
Cdd:COG2186  156 SGNPLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAI 196
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-204 1.36e-27

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 105.40  E-value: 1.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076   4 QPIRREAVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRRTAGL 83
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  84 ELAVGIARAAtgpalPELARDALEMRACIGADAARLCAARCSRETAAAVVEAAGAYAQAGPDLAALGEADIAWWRLIVEG 163
Cdd:COG2186   81 DPLALLLALD-----DASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEA 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 926315076 164 SGNLAYLLSFNSLVGGTLTVGDVPVDLRTAELLDVDAHVRL 204
Cdd:COG2186  156 SGNPLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAI 196
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 11-74 4.21e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 72.87  E-value: 4.21e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 926315076  11 VSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLV 74
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-166 7.53e-17

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 76.98  E-value: 7.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076   1 MTQQPIRREAVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLdwRRT 80
Cdd:PRK03837   4 LRSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVS--RPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  81 AG-----LELAVGIARAATGPALPEL--ARDALEmRACigadaARLCAARCSRETAAAVVEAAGAYAQAGPDLAALGEAD 153
Cdd:PRK03837  82 ADtiigqLSGMAKDFLSQSPDGLAHLkqARLFFE-SSL-----ARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSD 155

                        170
                 ....*....|...
gi 926315076 154 IAWWRLIVEGSGN 166
Cdd:PRK03837 156 MEFHRVIAEIPGN 168
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-74 4.95e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 64.94  E-value: 4.95e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 926315076   12 SDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLV 74
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
19-74 8.50e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 61.44  E-value: 8.50e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 926315076    19 LRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLV 74
Cdd:smart00345   5 LREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 10-78 2.01e-06

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 47.47  E-value: 2.01e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 926315076   10 AVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWR 78
Cdd:TIGR02325   8 ALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARR 76
 
Name Accession Description Interval E-value
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
4-204 1.36e-27

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 105.40  E-value: 1.36e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076   4 QPIRREAVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRRTAGL 83
Cdd:COG2186    1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  84 ELAVGIARAAtgpalPELARDALEMRACIGADAARLCAARCSRETAAAVVEAAGAYAQAGPDLAALGEADIAWWRLIVEG 163
Cdd:COG2186   81 DPLALLLALD-----DASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGEAFAEADLAFHRAIAEA 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 926315076 164 SGNLAYLLSFNSLVGGTLTVGDVPVDLRTAELLDVDAHVRL 204
Cdd:COG2186  156 SGNPLLALLLESLRELLRRSVRLTLRSPEARERSLAEHRAI 196
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 11-74 4.21e-17

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 72.87  E-value: 4.21e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 926315076  11 VSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLV 74
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 1-166 7.53e-17

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 76.98  E-value: 7.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076   1 MTQQPIRREAVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLdwRRT 80
Cdd:PRK03837   4 LRSRPIARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVS--RPS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  81 AG-----LELAVGIARAATGPALPEL--ARDALEmRACigadaARLCAARCSRETAAAVVEAAGAYAQAGPDLAALGEAD 153
Cdd:PRK03837  82 ADtiigqLSGMAKDFLSQSPDGLAHLkqARLFFE-SSL-----ARYAAEHATDEQIALLRKALERNSQSLGDNAAFIRSD 155

                        170
                 ....*....|...
gi 926315076 154 IAWWRLIVEGSGN 166
Cdd:PRK03837 156 MEFHRVIAEIPGN 168
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
2-166 8.10e-17

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 76.50  E-value: 8.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076   2 TQQPIRREAVSDQLHAVLRDRILTGTLPAGAPLtSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRrta 81
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLS--- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  82 glelavgiaraatgpalPELARDALEMRACIGADAARLCAARCSRETAAAVVEAAGAYAQA--GPDLAALGEADIAWWRL 159
Cdd:COG1802   79 -----------------PEEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAaaAGDVAAYLELDREFHRA 141


                 ....*..
gi 926315076 160 IVEGSGN 166
Cdd:COG1802  142 LVEAAGN 148
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-74 4.95e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 64.94  E-value: 4.95e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 926315076   12 SDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLV 74
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
14-93 5.42e-13

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 66.04  E-value: 5.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  14 QLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRRTAGLELAVGIARAA 93
Cdd:COG2188    9 QIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSFTEEL 88
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
19-74 8.50e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 61.44  E-value: 8.50e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 926315076    19 LRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLV 74
Cdd:smart00345   5 LREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
1-74 2.93e-10

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 58.49  E-value: 2.93e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 926315076   1 MTQQPIRREAVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLV 74
Cdd:PRK09464   1 MAYSKIRQPKLSDVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV 74
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
8-108 5.44e-09

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 52.49  E-value: 5.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076   8 REAVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRRTAGLELAV 87
Cdd:COG1725    8 GVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEERRE 87

                         90       100
                 ....*....|....*....|.
gi 926315076  88 GIARAatgpALPELARDALEM 108
Cdd:COG1725   88 EFLEE----ALRELVAEARRL 104
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 4-123 5.89e-08

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 52.08  E-value: 5.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076   4 QPIRREAVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRRTagl 83
Cdd:PRK09990   1 MKDERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRV--- 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 926315076  84 elavgiarAATGPAL------PELARDALEMRACIGADAARLCAAR 123
Cdd:PRK09990  78 --------QDASPLMhlfssqPRTLYDLLEVRALLEGESARLAALR 115
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 14-105 3.22e-07

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 50.60  E-value: 3.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  14 QLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDwrRTAGLELAVGIARAA 93
Cdd:COG1167   16 QLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA--RLPAPAPAPRAAAAV 93

                         90
                 ....*....|..
gi 926315076  94 TGPALPELARDA 105
Cdd:COG1167   94 AAPALRRLLEAA 105
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 11-176 3.79e-07

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 49.77  E-value: 3.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  11 VSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVlDWRRTAGLELAVGIA 90
Cdd:PRK10421   3 LSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI-RWRHETWSEQNIVQP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  91 RAATGPALPELARDALEMRACIGADAARLCAARCSRETAAAVVEAAGAYAQAGPDLAAlgEADIAWWRLIVEGSGNLAYL 170
Cdd:PRK10421  82 LKTLMADDPDYSFDILEARHAIEASTAWHAAMRATPGDKEKIQLCFEATLSEDPDLAS--QADVRFHLAIAEASHNVVLL 159


                 ....*.
gi 926315076 171 LSFNSL 176
Cdd:PRK10421 160 QTMRGF 165
PRK09764 PRK09764
GntR family transcriptional regulator;
1-78 1.14e-06

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 47.90  E-value: 1.14e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 926315076   1 MTQQPIRReavsdQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWR 78
Cdd:PRK09764   1 MGHKPLYR-----QIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEER 73
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 10-78 2.01e-06

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 47.47  E-value: 2.01e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 926315076   10 AVSDQLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWR 78
Cdd:TIGR02325   8 ALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARR 76
PRK11523 PRK11523
transcriptional regulator ExuR;
14-127 1.97e-05

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 44.45  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  14 QLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRRTAGLELAVGIARAA 93
Cdd:PRK11523  12 QLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQQAADNNMEFAN 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 926315076  94 TGPAlpELardaLEMRACIGADAARLCAARCSRE 127
Cdd:PRK11523  92 YGPF--EL----LQARQLIESNIAEFAATQVTKQ 119
PRK10225 PRK10225
Uxu operon transcriptional regulator;
14-127 2.22e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 44.24  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 926315076  14 QLHAVLRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVLDWRRTAGLELAVGIARAA 93
Cdd:PRK10225  13 EVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTDSPDANVCND 92

                         90       100       110
                 ....*....|....*....|....*....|....
gi 926315076  94 TGPAlpelarDALEMRACIGADAARLCAARCSRE 127
Cdd:PRK10225  93 AGPF------ELLQARQLLESNIAEFAALQATRE 120
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 19-64 7.42e-05

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 43.11  E-value: 7.42e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 926315076  19 LRDRILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLQQARLV 64
Cdd:PRK15481  14 IRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLA 59
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 2-75 9.40e-05

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 42.45  E-value: 9.40e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 926315076   2 TQQPIRREAVSDQLHAVLRDRILTGTLpagapLTSERELSAEFGVNRHAVREAVKRLQQARLVEVSHGGRTLVL 75
Cdd:PRK10079   8 TSYPTRYQEIAAKLEQELRQHYRCGDY-----LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVL 76
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
23-83 1.20e-03

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 39.08  E-value: 1.20e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 926315076  23 ILTGTLPAGAPLTSERELSAEFGVNRHAVREAVKRLqqAR--LVEVSHGGRTLVLDWRRTAGL 83
Cdd:PRK04984  20 IWNNRFPPGSILPAERELSELIGVTRTTLREVLQRL--ARdgWLTIQHGKPTKVNNFWETSGL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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